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Saccade and memory

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https://www.readbyqxmd.com/read/27916709/insights-to-the-schizophrenia-continuum-a-systematic-review-of-saccadic-eye-movements-in-schizotypy-and-biological-relatives-of-schizophrenia-patients
#1
REVIEW
Jessica B Myles, Susan L Rossell, Andrea Phillipou, Elizabeth Thomas, Caroline Gurvich
Myles, J.B., S. Rossell, A. Phillipou, Thomas, E and C. Gurvich. A systematic review of saccadic eye movements across the schizophrenia continuum: Characterisation, pathophysiology and genetic associations. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2015. One of the cognitive hallmarks of schizophrenia is impaired eye movements, particularly for the antisaccade task. Less saccade research has been conducted in relation to the broader schizophrenia continuum, that is, people with high schizotypy or first-degree relatives of people with schizophrenia...
December 1, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27866117/distinguishing-spinocerebellar-ataxia-with-pure-cerebellar-manifestation-from-multiple-system-atrophy-msa-c-through-saccade-profiles
#2
Yasuo Terao, Hideki Fukuda, Shin-Ichi Tokushige, Satomi Inomata-Terada, Akihiro Yugeta, Masashi Hamada, Yoshikazu Ugawa
OBJECTIVE: Patients with spinocerebellar ataxia with pure cerebellar presentation (SCD) and multiple system atrophy (MSA-C) show similar symptoms at early stages, although cerebellofugal pathology predominates in SCD, and cerebellopetal pathology in MSA-C. We studied whether saccade velocity profiles, which reflect the accelerating and braking functions of the cerebellum, can differentiate these two disorders. METHODS: We recorded visually guided (VGS) and memory guided saccades (MGS) in 29 MSA-C patients, 12 SCD patients, and 92 age-matched normal subjects, and compared their amplitude, peak velocity and duration (accelerating and decelerating phases)...
October 29, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27859647/spatial-but-not-oculomotor-information-biases-perceptual-memory-evidence-from-face-perception-and-cognitive-modeling
#3
Andrea L Wantz, Janek S Lobmaier, Fred W Mast, Walter Senn
Recent research put forward the hypothesis that eye movements are integrated in memory representations and are reactivated when later recalled. However, "looking back to nothing" during recall might be a consequence of spatial memory retrieval. Here, we aimed at distinguishing between the effect of spatial and oculomotor information on perceptual memory. Participants' task was to judge whether a morph looked rather like the first or second previously presented face. Crucially, faces and morphs were presented in a way that the morph reactivated oculomotor and/or spatial information associated with one of the previously encoded faces...
November 17, 2016: Cognitive Science
https://www.readbyqxmd.com/read/27807173/correlation-between-pupil-size-and-subjective-passage-of-time-in-non-human-primates
#4
Tomoki W Suzuki, Jun Kunimatsu, Masaki Tanaka
: Our daily experience of time is strongly influenced by internal states, such as arousal, attention, and mood. However, the underlying neuronal mechanism remains largely unknown. To investigate this, we recorded pupil diameter, which is closely linked to internal factors and neuromodulatory signaling, in monkeys performing the oculomotor version of the time production paradigm. In the self-timed saccade task, animals were required to make a memory-guided saccade during a predetermined time interval following a visual cue...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27807140/fef-inactivation-with-improved-optogenetic-methods
#5
Leah Acker, Erica N Pino, Edward S Boyden, Robert Desimone
Optogenetic methods have been highly effective for suppressing neural activity and modulating behavior in rodents, but effects have been much smaller in primates, which have much larger brains. Here, we present a suite of technologies to use optogenetics effectively in primates and apply these tools to a classic question in oculomotor control. First, we measured light absorption and heat propagation in vivo, optimized the conditions for using the red-light-shifted halorhodopsin Jaws in primates, and developed a large-volume illuminator to maximize light delivery with minimal heating and tissue displacement...
November 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27793591/association-between-comt-genotype-and-the-control-of-memory-guided-saccades-individual-differences-in-healthy-adults-reveal-a-detrimental-role-of-dopamine
#6
Jutta Billino, Jürgen Hennig, Karl R Gegenfurtner
The neural circuits involved in oculomotor control are well described; however, neuromodulation of eye movements is still hardly understood. Memory guided saccades have been extensively studied and in particular neurophysiological evidence from monkey studies points to a crucial functional role of prefrontal dopamine activity. We exploited individual differences in dopamine regulation due to the well established COMT (catechol-O-methyltransferase) Val(158)Met polymorphism to explore the link between prefrontal dopamine activity and memory guided saccades in healthy subjects...
October 25, 2016: Vision Research
https://www.readbyqxmd.com/read/27784206/perceptual-enhancement-as-a-result-of-a-top-down-attentional-influence-in-a-scene-viewing-task-evidence-from-saccadic-inhibition
#7
Mackenzie G Glaholt, Eyal M Reingold
Prior research has demonstrated that task instructions can influence the locations and durations of eye fixations during scene viewing. These task-related changes in gaze patterns are likely to be associated with a top-down influence of attention. In the present study we applied a saccadic-inhibition manipulation in order to detect another expected manifestation of top-down attention: perceptual enhancement. Participants viewed eight-item arrays containing colour photographs from two categories of scenes. Four of the eight photos depicted natural landscapes ("nature" scenes) and the other four depicted urban environments ("buildings" scenes)...
October 27, 2016: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/27773904/frontal-cortical-dysfunction-in-parkinson-s-disease-pd-comparison-of-memory-based-smooth-pursuit-and-anti-saccade-tasks-and-neuropsychological-and-motor-symptom-evaluations
#8
Norie Ito, Hidetoshi Takei, Susumu Chiba, Kikuro Fukushima
We reported recently that during a memory-based smooth-pursuit task, most Parkinson's disease (PD) patients exhibited normal cue-information memory but impaired smooth-pursuit preparation and execution. A minority of PD patients had abnormal cue-information memory or difficulty in understanding the task. To further examine differences between these two groups, we assigned an anti-saccade task and compared correct rates with various neuropsychological and motor symptom evaluations. The anti-saccade task requires voluntary saccades in the opposite direction to a visual stimulus, and patients with frontal cortical impairments are known to exhibit reflexive saccades (errors)...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27762577/saccadic-eye-movements-impose-a-natural-bottleneck-on-visual-short-term-memory
#9
Sven Ohl, Martin Rolfs
Visual short-term memory (VSTM) is a crucial repository of information when events unfold rapidly before our eyes, yet it maintains only a fraction of the sensory information encoded by the visual system. Here, we tested the hypothesis that saccadic eye movements provide a natural bottleneck for the transition of fragile content in sensory memory to VSTM. In 4 experiments, we show that saccades, planned and executed after the disappearance of a memory array, markedly bias visual memory performance. First, items that had appeared at the saccade target were more readily remembered than items that had appeared elsewhere, even though the saccade was irrelevant to the memory task (Experiment 1)...
October 20, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/27743259/object-files-across-eye-movements-previous-fixations-affect-the-latencies-of-corrective-saccades
#10
Martijn J Schut, Jasper H Fabius, Nathan Van der Stoep, Stefan Van der Stigchel
One of the factors contributing to a seamless visual experience is object correspondence-that is, the integration of pre- and postsaccadic visual object information into one representation. Previous research had suggested that before the execution of a saccade, a target object is loaded into visual working memory and subsequently is used to locate the target object after the saccade. Until now, studies on object correspondence have not taken previous fixations into account. In the present study, we investigated the influence of previously fixated information on object correspondence...
October 14, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27743143/scanpath-estimation-based-on-foveated-image-saliency
#11
Yixiu Wang, Bin Wang, Xiaofeng Wu, Liming Zhang
The estimation of gaze shift has been an important research area in saliency modeling. Gaze movement is a dynamic progress, yet existing estimation methods are limited to estimating scanpaths within only one saliency map, providing results with unsatisfactory accuracy. A bio-inspired method for gaze shift prediction is thus proposed. We take the effect of foveation into account in the proposed model, which plays an important role in the search for dynamic salient regions. The saccadic bias of gaze shifts and the mechanism of inhibition of return in short-term memory are also considered...
October 14, 2016: Cognitive Processing
https://www.readbyqxmd.com/read/27739609/disassociation-between-brain-activation-and-executive-function-in-fragile-x-premutation-females
#12
Annie L Shelton, Kim Cornish, Meaghan Clough, Sanuji Gajamange, Scott Kolbe, Joanne Fielding
Executive dysfunction has been demonstrated among premutation (PM) carriers (55-199 CGG repeats) of the Fragile X mental retardation 1 (FMR1) gene. Further, alterations to neural activation patterns have been reported during memory and comparison based functional magnetic resonance imaging (fMRI) tasks in these carriers. For the first time, the relationships between fMRI neural activation during an interleaved ocular motor prosaccade/antisaccade paradigm, and concurrent task performance (saccade measures of latency, accuracy and error rate) in PM females were examined...
October 14, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27698980/the-honeycomb-illusion-uniform-textures-not-perceived-as-such
#13
Marco Bertamini, Michael H Herzog, Nicola Bruno
We present a series of patterns, in which texture is perceived differently at fixation in comparison to the periphery, such that a physically uniform stimulus yields a nonuniform percept. We call this the Honeycomb illusion, and we discuss it in relation to the similar Extinction illusion (Ninio & Stevens, 2000). The effect remains strong despite multiple fixations, dynamic changes, and manipulations of the size of texture elements. We discuss the phenomenon in relation to how vision achieves a detailed and stable representation of the environment despite changes in retinal spatial resolution and dramatic changes across saccades...
July 2016: I-Perception
https://www.readbyqxmd.com/read/27681616/two-subdivisions-of-macaque-lip-process-visual-oculomotor-information-differently
#14
Mo Chen, Bing Li, Jing Guang, Linyu Wei, Si Wu, Yu Liu, Mingsha Zhang
Although the cerebral cortex is thought to be composed of functionally distinct areas, the actual parcellation of area and assignment of function are still highly controversial. An example is the much-studied lateral intraparietal cortex (LIP). Despite the general agreement that LIP plays an important role in visual-oculomotor transformation, it remains unclear whether the area is primary sensory- or motor-related (the attention-intention debate). Although LIP has been considered as a functionally unitary area, its dorsal (LIPd) and ventral (LIPv) parts differ in local morphology and long-distance connectivity...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27651148/striatal-dopamine-modulates-timing-of-self-initiated-saccades
#15
Jun Kunimatsu, Masaki Tanaka
The ability to adjust movement timing is essential in daily life. Explorations of the underlying neural mechanisms have reported a gradual increase or decrease in neuronal activity prior to self-timed movements within the cortico-basal ganglia loop. Previous studies in both humans and animals have shown that endogenous dopamine (DA) plays a modulatory role in self-timing. However, the specific site of dopaminergic regulation remains elusive because the systemic application of DA-related substances can directly alter both cortical and subcortical neuronal activities...
September 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27649776/pharmacological-interactions-between-brivaracetam-and-ethanol-in-healthy-males
#16
Annelieke C Kruithof, Shikiko Watanabe, Pierre Am Peeters, Marieke L de Kam, Rob Gja Zuiker, Jasper Stevens, Joop Ma van Gerven, Armel Stockis
This double-blind, randomized, three-way crossover study explored the potential pharmacokinetic and pharmacodynamic interactions between ethanol and brivaracetam in 18 healthy males, as required for the development of CNS-active drugs. Subjects received (A) ethanol+brivaracetam, (B) ethanol placebo+brivaracetam and (C) ethanol+brivaracetam placebo. Ethanol was infused as a 5.5-hour intravenous clamp with the first 0.5-hour as loading phase to a target level of 0.6 g/L, and brivaracetam was orally administered as a single 200 mg dose...
September 20, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27639418/saccadic-eye-movements-as-markers-of-schizophrenia-spectrum-exploration-in-at-risk-mental-states
#17
Simona Caldani, Maria Pia Bucci, Jean-Charles Lamy, Magali Seassau, Narjes Bendjemaa, Rémi Gadel, Raphael Gaillard, Marie-Odile Krebs, Isabelle Amado
Schizophrenia is a neurodevelopmental disease with cognitive and motor impairments. Motor dysfunctions, such as eye movements or Neurological Soft Signs (NSS), are proposed as endophenotypic markers. Antisaccade (AS) and memory-guided saccades (MGS), two markers of inhibitory control mechanism, are altered in both patients with schizophrenia and their relatives, although these tools may have different sensitivities. Recently, emphasis has been put on identifying markers predictive of psychosis transition in subjects with ultra-high-risk psychosis in order to develop targeted prevention...
September 14, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27631767/the-role-of-the-oculomotor-system-in-updating-visual-spatial-working-memory-across-saccades
#18
Paul J Boon, Artem V Belopolsky, Jan Theeuwes
Visual-spatial working memory (VSWM) helps us to maintain and manipulate visual information in the absence of sensory input. It has been proposed that VSWM is an emergent property of the oculomotor system. In the present study we investigated the role of the oculomotor system in updating of spatial working memory representations across saccades. Participants had to maintain a location in memory while making a saccade to a different location. During the saccade the target was displaced, which went unnoticed by the participants...
2016: PloS One
https://www.readbyqxmd.com/read/27594825/ecological-origins-of-object-salience-reward-uncertainty-aversiveness-and-novelty
#19
Ali Ghazizadeh, Whitney Griggs, Okihide Hikosaka
Among many objects around us, some are more salient than others (i.e., attract our attention automatically). Some objects may be inherently salient (e.g., brighter), while others may become salient by virtue of their ecological relevance through experience. However, the role of ecological experience in automatic attention has not been studied systematically. To address this question, we let subjects (macaque monkeys) view a large number of complex objects (>300), each experienced repeatedly (>5 days) with rewarding, aversive or no outcome association (mere-perceptual exposure)...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27564993/object-finding-skill-created-by-repeated-reward-experience
#20
Ali Ghazizadeh, Whitney Griggs, Okihide Hikosaka
For most animals, survival depends on rapid detection of rewarding objects, but search for an object surrounded by many others is known to be difficult and time consuming. However, there is neuronal evidence for robust and rapid differentiation of objects based on their reward history in primates (Hikosaka, Kim, Yasuda, & Yamamoto, 2014). We hypothesized that such robust coding should support efficient search for high-value objects, similar to a pop-out mechanism. To test this hypothesis, we let subjects (n = 4, macaque monkeys) view a large number of complex objects with consistently biased rewards with variable training durations (1, 5, or 30 + days)...
August 1, 2016: Journal of Vision
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