B Yao, S F W Neggers, M Rolfs, L Rösler, I A Thompson, H J Hopman, L Ghermezi, R S Kahn, K N Thakkar
By predicting sensory consequences of actions, humans can distinguish self-generated sensory inputs from those that are elicited externally. This is one mechanism by which we achieve a subjective sense of agency over our actions. Corollary discharge signals (CD)-"copies" of motor signals sent to sensory areas-permit such predictions, and CD abnormalities are a hypothesized mechanism for the agency disruptions in schizophrenia that characterize a subset of symptoms. Indeed, behavioral evidence of altered CD, including in the oculomotor system, has been observed in schizophrenia patients...
January 10, 2019: Journal of Neuroscience