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Arterial spin labeling

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https://www.readbyqxmd.com/read/29136305/neural-basis-of-exertional-fatigue-in-the-heat-a-review-of-magnetic-resonance-imaging-methods
#1
REVIEW
X R Tan, Ivan C C Low, Mary C Stephenson, T W Soong, Jason K W Lee
The central nervous system, specifically the brain, is implicated in the development of exertional fatigue under a hot environment. Diverse neuroimaging techniques have been used to visualize the brain activity during or after exercise. Notably, the use of magnetic resonance imaging (MRI) has become prevalent due to its excellent spatial resolution and versatility. This review evaluates the significance and limitations of various brain MRI techniques in exercise studies - brain volumetric analysis, functional MRI, functional connectivity MRI and arterial spin labelling...
November 14, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29135072/measuring-human-placental-blood-flow-with-multidelay-3d-grase-pseudocontinuous-arterial-spin-labeling-at-3t
#2
Xingfeng Shao, Dapeng Liu, Thomas Martin, Teresa Chanlaw, Sherin U Devaskar, Carla Janzen, Aisling M Murphy, Daniel Margolis, Kyunghyun Sung, Danny J J Wang
BACKGROUND: Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured noninvasively using arterial spin labeling (ASL). PURPOSE: To present a multidelay pseudocontinuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29125633/usability-of-functional-mri-in-clinical-studies-for-fast-and-reliable-assessment-of-renal-perfusion-and-quantification-of-hemodynamic-effects-on-the-kidney
#3
Tobias Getzin, Marcus May, Martina Schmidbauer, Marcel Gutberlet, Petros Martirosian, Reinhard Oertel, Frank Wacker, Christoph Schindler, Katja Hueper
The purpose of this study was to evaluate contrast-media-free arterial spin labeling, a technique of functional magnetic resonance imaging (MRI), for assessment of kidney perfusion in a clinical study. We examined renal perfusion by arterial spin labeling in 15 healthy adults using a clinical 1.5-T MRI system, twice under baseline conditions and 60 minutes after a single oral dose of 50 mg captopril. Data evaluation included assessment of interstudy and interrater reproducibility in addition to the pharmacological effect of captopril on kidney perfusion and a sample size calculation for potential application of the technique in pharmacological intervention studies...
November 10, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29117962/lower-cardiac-index-levels-relate-to-lower-cerebral-blood-flow-in-older-adults
#4
Angela L Jefferson, Dandan Liu, Deepak K Gupta, Kimberly R Pechman, Jennifer M Watchmaker, Elizabeth A Gordon, Swati Rane, Susan P Bell, Lisa A Mendes, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Thomas J Wang, Manus J Donahue
OBJECTIVE: To assess cross-sectionally whether lower cardiac index relates to lower resting cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) among older adults. METHODS: Vanderbilt Memory & Aging Project participants free of stroke, dementia, and heart failure were studied (n = 314, age 73 ± 7 years, 59% male, 39% with mild cognitive impairment). Cardiac index (liters per minute per meter squared) was quantified from echocardiography. Resting CBF (milliliters per 100 grams per minute) and hypercapnia-induced CVR were quantified from pseudo-continuous arterial spin-labeling MRI...
November 8, 2017: Neurology
https://www.readbyqxmd.com/read/29108372/aberrant-patterns-of-brain-cerebral-blood-flow-in-chinese-han-first-episode-drug-na%C3%A3-ve-depressive-patients-with-and-without-a-family-history-of-depression
#5
Shikai Wang, Lina Wang, Ping Jing, Ping Guo, Weifang Zheng, Jie Li, Mincai Qian
A positive family history plays a key role in the brain pathology of depression patients and previous research has confirmed that disturbed mood maintenance may be related to abnormal regional cerebral blood flow (rCBF). However, little is known about whether the rCBF is different between depression patients with and without family histories. To address this question, we examined the rCBF in drug-naïve, first-episode depression patients with and without family histories of depression using a 3D pseudo-continuous arterial spin-labelling technique...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29106745/demonstration-of-velocity-selective-myocardial-arterial-spin-labeling-perfusion-imaging-in-humans
#6
Terrence R Jao, Krishna S Nayak
PURPOSE: Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS: Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC  = 10-40 cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y)...
November 6, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29105017/patch-based-local-learning-method-for-cerebral-blood-flow-quantification-with-arterial-spin-labeling-mri
#7
Hancan Zhu, Guanghua He, Ze Wang
Arterial spin-labeling (ASL) perfusion MRI is a non-invasive method for quantifying cerebral blood flow (CBF). Standard ASL CBF calibration mainly relies on pair-wise subtraction of the spin-labeled images and controls images at each voxel separately, ignoring the abundant spatial correlations in ASL data. To address this issue, we previously proposed a multivariate support vector machine (SVM) learning-based algorithm for ASL CBF quantification (SVMASLQ). But the original SVMASLQ was designed to do CBF quantification for all image voxels simultaneously, which is not ideal for considering local signal and noise variations...
November 6, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29100305/cerebral-blood-flow-changes-in-remitted-early-and-late-onset-depression-patients
#8
Wenxiang Liao, Ze Wang, Xiangrong Zhang, Hao Shu, Zan Wang, Duan Liu, Zhijun Zhang
Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095282/skull-metastases-detecting-on-arterial-spin-labeling-perfusion-three-case-reports-and-review-of-literature
#9
REVIEW
Kyeong H Ryu, Hye J Baek, Soo B Cho, Jin I Moon, Bo H Choi, Sung E Park, Hyo J An
RATIONALE: Detection of skull metastases is as important as detection of brain metastases because early diagnosis of skull metastases is a crucial determinant of treatment. However, the skull can be a blind spot for assessing metastases on routine brain magnetic resonance imaging (MRI). To the best of our knowledge, the finding of skull metastases on arterial spin labeling (ASL) has not been reported. ASL is a specific MRI sequence for evaluating cerebral blood flow using magnetized endogenous inflow blood...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29091052/transcranial-doppler-of-the-middle-cerebral-artery-indicates-regional-gray-matter-cerebral-perfusion
#10
Evan P Pasha, Takashi Tarumi, Andreana P Haley, Hirofumi Tanaka
INTRODUCTION: We determined if transcranial color-coded Doppler derived hemodynamics are associated with MRI based cerebral blood flow (CBF) in regions clinically important to dementia in healthy middle-aged adults. METHODS: In thirty subjects (18m/12f; age=52±1 years), blood flow velocity (BFV) and cerebrovascular conductance (CVC) were measured with transcranial color-coded Doppler (TCCD) at the middle cerebral artery (MCA) and cerebral blood flow (CBF) was assessed with arterial spin labeled perfusion MRI...
November 1, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29065769/imaging-of-cerebrovascular-function-in-chronic-traumatic-brain-injury
#11
Franck Amyot, Kimbra Kenney, Carol Moore, Maraglit Harber, L Christine Turtzo, Christian N Shenouda, Erika Silverman, Yunhua Gong, Bao-Xi Qu, Leah Harburg, Hangzang Lu, Eric Wassermann, Ramon Diaz-Arrastia
Traumatic cerebrovascular injury (TCVI) is a common pathologic mechanism of traumatic brain injury (TBI) and presents an attractive target for intervention. The aims of this study were to assess cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) using magnetic resonance imaging (MRI), to assess their value as biomarkers of TCVI in chronic TBI, characterize the spatial distribution of TCVI, and assess the relationships between each biomarker and neuropsychological and clinical assessments. 42 subjects (27 chronic TBI, 15 age and gender-matched healthy volunteers) were studied cross-sectionally...
October 25, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29062276/enhancing-innovation-and-underlying-neural-mechanisms-via-cognitive-training-in-healthy-older-adults
#12
Sandra B Chapman, Jeffrey S Spence, Sina Aslan, Molly W Keebler
Non-invasive interventions, such as cognitive training (CT) and physical exercise, are gaining momentum as ways to augment both cognitive and brain function throughout life. One of the most fundamental yet little studied aspects of human cognition is innovative thinking, especially in older adults. In this study, we utilize a measure of innovative cognition that examines both the quantity and quality of abstracted interpretations. This randomized pilot trial in cognitively normal adults (56-75 years) compared the effect of cognitive reasoning training (SMART) on innovative cognition as measured by Multiple Interpretations Measure (MIM)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29059301/steady-state-vs-pulsatile-blood-pressure-component-and-regional-cerebral-perfusion
#13
Jitanan Laosiripisan, Andreana P Haley, Hirofumi Tanaka
BACKGROUND: Arterial blood pressure (BP) can be divided into steady state component that is determined by mean arterial pressure and pulsatile component that is explored by pulse pressure (PP). We determined relationships between BP components and regional cerebral perfusion. METHODS: A total of 52 apparently healthy and cognitively normal adults aged 40-60 years were studied. Regional cerebral perfusion was measured using functional magnetic resonance imaging (MRI) arterial spin labeling technique in 10 a priori regions of interest...
November 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29055725/evaluation-of-prolonged-administration-of-isoflurane-on-cerebral-blood-flow-and-default-mode-network-in-macaque-monkeys-anesthetized-with-different-maintenance-doses
#14
Chun-Xia Li, Xiaodong Zhang
OBJECT: Isoflurane is a commonly used volatile anesthetic agent in clinical anesthesia and biomedical research. Prior study suggested the cerebral blood flow (CBF) and default mode network (DMN) could be changed after prolonged administration of isoflurane. The normal maintenance doses of isoflurane may vary from light (∼0.75%) to deep (∼1.5 or 2%) anesthesia. However, it is not clear how the duration effects are affected by the altered doses. The present study is aimed to examine if the duration effects are affected when isoflurane concentration is altered within normal maintenance doses...
October 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29053782/seizure-onset-zone-localization-using-postictal-hypoperfusion-detected-by-arterial-spin-labelling-mri
#15
Ismael Gaxiola-Valdez, Shaily Singh, Tefani Perera, Sherry Sandy, Emmy Li, Paolo Federico
Neurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measures cerebral perfusion...
November 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29044603/comorbid-masticatory-impairment-delays-recovery-from-acute-cerebral-ischemia-and-locomotor-hypoactivity-after-subarachnoid-hemorrhage-in-mice
#16
Ikuho Kojima, Tatsushi Mutoh, Kazumasu Sasaki, Yasuko Tatewaki, Yasuyuki Taki, Tatsuya Ishikawa
Tooth loss and related changes in the functionality may lead to worse outcome of stroke patients, but the link involved in this pathway remains unclear. This study aimed to determine the effect of comorbid masticatory impairment on acute cerebral ischemia and neurobehavioral outcome after experimental subarachnoid hemorrhage (SAH). Thirty C57BL/6 mice with (molar-less) or without (control) prior treatment of cutting off the upper molars (separated by at least one week), were subjected to SAH by endovascular perforation...
October 17, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29038202/brain-regional-blood-flow-and-working-memory-performance-predict-change-in-blood-pressure-over-2-years
#17
J Richard Jennings, Alicia F Heim, Lei K Sheu, Matthew F Muldoon, Christopher Ryan, H Michael Gach, Claudiu Schirda, Peter J Gianaros
Hypertension is a presumptive risk factor for premature cognitive decline. However, lowering blood pressure (BP) does not uniformly reverse cognitive decline, suggesting that high BP per se may not cause cognitive decline. We hypothesized that essential hypertension has initial effects on the brain that, over time, manifest as cognitive dysfunction in conjunction with both brain vascular abnormalities and systemic BP elevation. Accordingly, we tested whether neuropsychological function and brain blood flow responses to cognitive challenges among prehypertensive individuals would predict subsequent progression of BP...
December 2017: Hypertension
https://www.readbyqxmd.com/read/29038061/structural-and-functional-brain-changes-at-early-and-late-stages-of-complex-regional-pain-syndrome
#18
Mahsa Shokouhi, Collin Clarke, Patricia Morley-Forster, Dwight E Moulin, Karen Davis, Keith St Lawrence
Brain plasticity is demonstrated in complex regional pain syndrome (CRPS), although it is unclear how it modulates at different stages of CRPS. The observation that symptoms can progress over time suggests that the pattern of brain changes might also evolve. We measured structural and functional changes as well as sensorimotor integration at early and late stages (ES and LS) of CRPS. Twelve ES patients, sixteen LS patients, and sixteen age- and sex-matched controls were recruited. Gray matter (GM) volume was estimated using voxel-based morphometry...
October 13, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29034514/measurement-of-murine-single-kidney-glomerular-filtration-rate-using-dynamic-contrast-enhanced-mri
#19
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: To develop and validate a method for measuring murine single-kidney glomerular filtration rate (GFR) using dynamic contrast-enhanced MRI (DCE-MRI). METHODS: This prospective study was approved by the Institutional Animal Care and Use Committee. A fast longitudinal relaxation time (T1 ) measurement method was implemented to capture gadolinium dynamics (1 s/scan), and a modified two-compartment model was developed to quantify GFR as well as renal perfusion using 16...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29033829/exercise-training-increases-parietal-lobe-cerebral-blood-flow-in-chronic-stroke-an-observational-study
#20
Andrew D Robertson, Susan Marzolini, Laura E Middleton, Vincenzo S Basile, Paul I Oh, Bradley J MacIntosh
Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart...
2017: Frontiers in Aging Neuroscience
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