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Arterial spin labeling

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https://www.readbyqxmd.com/read/29781581/brain-correlates-of-continuous-pain-in-rheumatoid-arthritis-as-measured-by-pulsed-arterial-spin-labeling
#1
Yvonne C Lee, Alexander Fine, Ekaterina Protsenko, Elena Massarotti, Robert R Edwards, Ishtiaq Mawla, Vitaly Napadow, Marco L Loggia
OBJECTIVE: Central nervous system pathways involving pain modulation shape the pain experience in patients with chronic pain. Our objectives were to understand the mechanisms underlying pain in rheumatoid arthritis (RA) and identify brain signals that may serve as imaging markers for developing targeted treatments for RA pain. METHODS: Subjects with RA and matched controls underwent functional magnetic resonance imaging, using pulsed arterial spin labeling (pASL)...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29780351/cerebral-blood-flow-changes-in-multiple-sclerosis-and-neuromyelitis-optica-and-their-correlations-with-clinical-disability
#2
Xue Zhang, Xi Guo, Ningnannan Zhang, Huanhuan Cai, Jie Sun, Qiuhui Wang, Yuan Qi, Linjie Zhang, Li Yang, Fu-Dong Shi, Chunshui Yu
Distinguishing relapsing-remitting multiple sclerosis (RRMS) and neuromyelitis optica (NMO) is clinically important because they differ in prognosis and treatment. This study aimed to identify perfusion abnormalities in RRMS and NMO and their correlations with gray matter volume (GMV) atrophy and clinical parameters. Structural and arterial spin labeling MRI scans were performed in 39 RRMS patients, 62 NMO patients, and 73 healthy controls. The gray matter cerebral blood flow (CBF) values were voxel-wisely compared among the three groups with and without GMV correction...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29777822/effects-of-global-signal-regression-and-subtraction-methods-on-resting-state-functional-connectivity-using-arterial-spin-labeling-data
#3
João Paulo Santos Silva, Luciana da Mata Mônaco, André Monteiro Paschoal, Ícaro Agenor Ferreira de Oliveira, Renata Ferranti Leoni
BACKGROUND: Arterial spin labeling (ASL) is an established magnetic resonance imaging (MRI) technique that is finding broader applications in functional studies of the healthy and diseased brain. To promote improvement in cerebral blood flow (CBF) signal specificity, many algorithms and imaging procedures, such as subtraction methods, were proposed to eliminate or, at least, minimize noise sources. Therefore, this study addressed the main considerations of how CBF functional connectivity (FC) is changed, regarding resting brain network (RBN) identification and correlations between regions of interest (ROI), by different subtraction methods and removal of residual motion artifacts and global signal fluctuations (RMAGSF)...
May 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29777360/crossed-aphasia-following-cerebral-infarction-in-a-right-handed-patient-with-atypical-cerebral-language-dominance
#4
Xiaoping Tan, Yang Guo, Saihong Dun, Hongzan Sun
OBJECTIVE: Crossed aphasia (CA), usually referred to as an acquired language disturbance, is caused by a lesion in the cerebral hemisphere ipsilateral to the dominant hand, and the exact mechanism is not clear. The development of handedness is influenced by education and training and the impact of habitualization, while language is more susceptible to the impact of speech habits, and it is not absolutely accurate to judge cerebral language dominance by the degree of hand preference. METHODS: We describe a case of CA after right hemispheric stroke in a right-handed patient with atypical language dominance and attempt to analyze the mechanism of CA based on functional imaging methods, including arterial spin labeling (ASL) and positron emission tomography/magnetic resonance imaging (PET-MRI)...
May 18, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29777252/noninvasively-evaluating-the-grading-and-idh1-mutation-status-of-diffuse-gliomas-by-three-dimensional-pseudo-continuous-arterial-spin-labeling-and-diffusion-weighted-imaging
#5
Tingting Liu, Guang Cheng, Xiaowei Kang, Yibin Xi, Yuanqiang Zhu, Kai Wang, Chao Sun, Jing Ye, Ping Li, Hong Yin
PURPOSE: To noninvasively evaluate the value of three-dimensional pseudo-continuous arterial spin labeling (3D pCASL) and diffusion-weighted imaging (DWI) in diffuse gliomas grading as well as isocitrate dehydrogenase (IDH) 1 mutation status. METHODS: Fifty-six patients with pathologically confirmed diffuse gliomas with preoperative 3D pCASL and DWI were enrolled in this study. The Student's t test and Mann-Whitney U test were used to evaluate differences in parameters of DWI and 3D pCASL between low and high grade as well as between mutant and wild-type IDH1 diffuse gliomas; receiver operator characteristic (ROC) analysis was used to assess the diagnostic performance...
May 18, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29770492/accelerated-3d-grase-imaging-improves-quantitative-multiple-post-labeling-delay-arterial-spin-labeling
#6
Markus Boland, Rüdiger Stirnberg, Eberhard D Pracht, Johanna Kramme, Roberto Viviani, Julia Stingl, Tony Stöcker
PURPOSE: To investigate the impact of accelerated, single-shot 3D-GRASE acquisition on quantitative arterial spin labeling (ASL) with multiple and single post-labeling delay (PLD) in terms of perfusion-weighted SNR per unit scan time (TSNRPW ) and quantification accuracy. METHODS: Five subjects were scanned on a 3T MRI scanner using the pseudo-continuous arterial spin labeling (PCASL) technique with a 3D-GRASE imaging sequence capable of parallel imaging acceleration...
May 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29769414/clinical-utility-of-arterial-spin-labeling-for-preoperative-grading-of-glioma-a-diagnostic-meta-analysis
#7
Linchen Li, Xinjun Wang, Min Zhang, Yan Zhang
There were obvious differences in biological behavior and prognosis between low-grade glioma and high-grade glioma, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through November 10, 2017 and used "arterial spin-labeling" OR "ASL perfusion, grading" OR "differentiation, glioma" OR "glial tumor, diagnostic test" as the search terms...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29769375/baseline-nawm-structural-integrity-and-cbf-predict-periventricular-wmh-expansion-over-time
#8
Nutta-On Promjunyakul, Hiroko H Dodge, David Lahna, Erin L Boespflug, Jeffrey A Kaye, William D Rooney, Lisa C Silbert
OBJECTIVE: We aimed to describe and compare baseline cerebral blood flow (CBF) and microstructural characteristics of normal-appearing white matter (NAWM) within the vulnerable periventricular white matter hyperintensity (PVWMH) penumbra region in predicting white matter hyperintensity (WMH) growth over time. METHODS: Fifty-two patients, aged 82.8 years, underwent serial brain MRI, including pulsed arterial spin labeling and diffusion tensor imaging (DTI). New WMH and persistent NAWM voxels in relation to WMH penumbra at follow-up were identified...
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29764033/-the-combined-application-of-magnetic-resonance-dti-and-3d-pcasl-in-differential-diagnosis-of-hyper-acute-and-acute-ischemic-cerebral-infarction
#9
Z Y Dai, F Chen, L Z Yao, C S Dong, H C Shi, P L Pan, Y Liu, Z P Zhang
Objective: To explore the clinical value of magnetic resonance diffusion tensor imaging (DTI) combined with 3D pseudo continuous arterial spin labeling (3D-pcASL) perfusion imaging in differential diagnosis of hyper-acute and acute ischemic cerebral infarction. Methods: A total of 42 patients with confirmed unilateral ischemic cerebral infarction from February 2015 to October 2017 of Affiliated Yancheng Hospital of Southeast University Medical College were collected. DTI and 3D-pcASL images of hyper-acute (14 patients, group A) and acute (28 patients, group B) ischemic cerebral infarction were retrospectively analyzed...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29762090/alzheimer-disease-and-mild-cognitive-impairment-integrated-pulsed-arterial-spin-labeling-mri-and-18-f-fdg-pet
#10
Isabelle Riederer, Karl Peter Bohn, Christine Preibisch, Eva Wiedemann, Claus Zimmer, Panagiotis Alexopoulos, Stefan Förster
Purpose To compare PET/MR hypoperfusion and hypometabolism in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) compared with healthy control (HC) participants. Materials and Methods Maps of cerebral blood flow (CBF; pulsed arterial spin-labeling [ASL] MRI), glucose metabolism (fluorine 18 [18 F] fluorodeoxyglucose [FDG] PET), and gray matter (GM) volume (structural T1-weighted MRI) were calculated from integrated PET/MR data in 45 patients with AD (mean age, 69 years ± 9 [standard deviation]; age range, 51-89 years), 20 patients with MCI (mean age, 64 years ± 10; age range, 45-82 years), and 11 HC participants (mean age, 65 years ± 8; age range, 54-80 years) between 2011 and 2014...
May 15, 2018: Radiology
https://www.readbyqxmd.com/read/29760644/an-algorithm-for-preclinical-diagnosis-of-alzheimer-s-disease
#11
REVIEW
Tapan K Khan
Almost all Alzheimer's disease (AD) therapeutic trials have failed in recent years. One of the main reasons for failure is due to designing the disease-modifying clinical trials at the advanced stage of the disease when irreversible brain damage has already occurred. Diagnosis of the preclinical stage of AD and therapeutic intervention at this phase, with a perfect target, are key points to slowing the progression of the disease. Various AD biomarkers hold enormous promise for identifying individuals with preclinical AD and predicting the development of AD dementia in the future, but no single AD biomarker has the capability to distinguish the AD preclinical stage...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29759739/aortic-valve-bypass-surgery-in-severe-aortic-valve-stenosis-insights-from-cardiac-and-brain-magnetic-resonance-imaging
#12
Cesare Mantini, Massimo Caulo, Daniele Marinelli, Piero Chiacchiaretta, Armando Tartaro, Antonio Raffaele Cotroneo, Gabriele Di Giammarco
OBJECTIVE: To investigate and describe the distribution of aortic and cerebral blood flow (CBF) in patients with severe valvular aortic stenosis (AS) before and after aortic valve bypass (AVB) surgery. METHODS: We enrolled 10 consecutive patients who underwent AVB surgery for severe AS. Cardiovascular magnetic resonance imaging (CMR) and brain magnetic resonance imaging were performed as baseline before surgery and twice after surgery. Quantitative flow measurements were obtained using 1...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29754022/resilience-and-amygdala-function-in-older-healthy-and-depressed-adults
#13
Amber M Leaver, Hongyu Yang, Prabha Siddarth, Roza M Vlasova, Beatrix Krause, Natalie St Cyr, Katherine L Narr, Helen Lavretsky
BACKGROUND: Previous studies suggest that low emotional resilience may correspond with increased or over-active amygdala function. Complementary studies suggest that emotional resilience increases with age; older adults tend to have decreased attentional bias to negative stimuli compared to younger adults. Amygdala nuclei and related brain circuits have been linked to negative affect, and depressed patients have been demonstrated to have abnormal amygdala function. METHODS: In the current study, we correlated psychological resilience measures with amygdala function measured with resting-state arterial spin-labelled (ASL) and blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in older adults with and without depression...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29748641/xiaoshuan-enteric-coated-capsule-alleviates-cognitive-impairment-by-enhancing-hippocampal-glucose-metabolism-hemodynamics-and-neuroplasticity-of-rat-with-chronic-cerebral-hypoperfusion
#14
Man-Zhong Li, Yi Zhang, Hai-Yan Zou, Ya-Li Wang, Brian-Chi Yan Cheng, Lei Wang, Qiu-Xia Zhang, Jian-Feng Lei, Hui Zhao
Chronic cerebral hypoperfusion (CCH) is identified as a critical risk factor of dementia in patients with cerebrovascular disease. Xiaoshuan enteric-coated capsule (XSECC) is a compound Chinese medicine approved by Chinese State Food and Drug Administration for promoting brain remodeling and plasticity after stroke. The present study aimed to explore the potential of XSECC to improve cognitive function after CCH and further investigate the underlying mechanisms. CCH was induced by bilateral common carotid artery occlusion (BCCAO) in rats...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748205/cerebral-perfusion-is-perturbed-by-preterm-birth-and-brain-injury
#15
E S Mahdi, M Bouyssi-Kobar, M B Jacobs, J Murnick, T Chang, C Limperopoulos
BACKGROUND AND PURPOSE: Early disturbances in systemic and cerebral hemodynamics are thought to mediate prematurity-related brain injury. However, the extent to which CBF is perturbed by preterm birth is unknown. Our aim was to compare global and regional CBF in preterm infants with and without brain injury on conventional MR imaging using arterial spin-labeling during the third trimester of ex utero life and to examine the relationship between clinical risk factors and CBF. MATERIALS AND METHODS: We prospectively enrolled preterm infants younger than 32 weeks' gestational age and <1500 g and performed arterial spin-labeling MR imaging studies...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29744796/arterial-spin-labeling-reveals-relationships-between-resting-cerebral-perfusion-and-motor-learning-in-parkinson-s-disease
#16
Amy Barzgari, Jitka Sojkova, N Maritza Dowling, Vincent Pozorski, Ozioma C Okonkwo, Erika J Starks, Jennifer Oh, Frances Thiesen, Alexandra Wey, Christopher R Nicholas, Sterling Johnson, Catherine L Gallagher
Parkinson's disease (PD) is an age-related neurodegenerative disease that produces changes in movement, cognition, sleep, and autonomic function. Motor learning involves acquisition of new motor skills through practice, and is affected by PD. The purpose of the present study was to evaluate regional differences in resting cerebral blood flow (rCBF), measured using arterial spin labeling (ASL) MRI, during a finger-typing task of motor skill acquisition in PD patients compared to age- and gender-matched controls...
May 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29742722/arterial-spin-labeling-mr-imaging-aids-to-identify-cortical-venous-drainage-of-dural-arteriovenous-fistulas
#17
Ji Hee Kang, Tae Jin Yun, Jong Kook Rhim, Young Dae Cho, Dong Hyun Yoo, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cortical venous drainage (CVD) increases the probability of intracranial hemorrhage and mortality rate of dural arteriovenous fistulas (DAVF). Although digital subtraction angiography (DSA) is the most accurate method to determine CVD in DAVFs, this modality has limitations due to its invasive nature and radiation issues. The purpose of this study was to evaluate the diagnostic utility of arterial spin-labeling perfusion-weighted images (ASL-PWI) to identify CVD in patients with DAVF.The Institutional Review Board of our hospital approved this retrospective study...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29737389/4d-asl-based-mr-angiography-for-visualization-of-distal-arteries-and-leptomeningeal-collateral-vessels-in-moyamoya-disease-a-comparison-of-techniques
#18
Osamu Togao, Akio Hiwatashi, Makoto Obara, Koji Yamashita, Daichi Momosaka, Ataru Nishimura, Koichi Arimura, Nobuhiro Hata, Koji Yoshimoto, Koji Iihara, Marc Van Cauteren, Hiroshi Honda
OBJECTIVES: To evaluate the performance of four-dimensional pseudo-continuous arterial spin labeling (4D-pCASL)-based angiography using CENTRA-keyhole and view sharing (4D-PACK) in the visualization of flow dynamics in distal cerebral arteries and leptomeningeal anastomosis (LMA) collaterals in moyamoya disease in comparison with contrast inherent inflow-enhanced multiphase angiography (CINEMA), with reference to digital subtraction angiography (DSA). METHODS: Thirty-two cerebral hemispheres from 19 patients with moyamoya disease (mean age, 29...
May 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29722099/deficient-supplementary-motor-area-at-rest-neural-basis-of-limb-kinetic-deficits-in-parkinson-s-disease
#19
Stefanie Kübel, Katharina Stegmayer, Tim Vanbellingen, Sebastian Walther, Stephan Bohlhalter
Parkinson's disease (PD) patients frequently suffer from limb kinetic apraxia (LKA) affecting quality of life. LKA denotes an impairment of precise and independent finger movements beyond bradykinesia, which is reliably assessed by coin rotation (CR) task. BOLD fMRI detected activation of a left inferior parietal-premotor praxis network in PD during CR. Here, we explored which network site is most critical for LKA using arterial spin labeling (ASL). Based on a hierarchical model, we hypothesized that LKA would predominantly affect the functional integrity of premotor areas including supplementary motor areas (SMA)...
May 2, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29719627/a-comparison-of-arterial-spin-labeling-and-dynamic-susceptibility-perfusion-imaging-for-resection-control-in-glioblastoma-surgery
#20
Thomas Lindner, Hajrullah Ahmeti, Julia Juhasz, Michael Helle, Olav Jansen, Michael Synowitz, Stephan Ulmer
Resection control using magnetic resonance imaging during neurosurgical interventions increases confidence regarding the extent of tumor removal already during the procedure. In addition to morphological imaging, functional information such as perfusion might become an important marker of the presence and extent of residual tumor mass. The aim of this study was to implement arterial spin labeling (ASL) perfusion imaging as a noninvasive alternative to dynamic susceptibility contrast (DSC) perfusion imaging in patients suffering from intra-axial tumors for resection control already during surgery...
April 6, 2018: Oncotarget
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