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Arterial spin labeling

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https://www.readbyqxmd.com/read/28328739/effects-of-a-brief-cognitive-behavioural-therapy-group-intervention-on-baseline-brain-perfusion-in-adolescents-with-major-depressive-disorder
#1
Zrinka Sosic-Vasic, Birgit Abler, Georg Grön, Paul Plener, Joana Straub
A number of neuroimaging studies have identified altered regional cerebral blood flow (rCBF) related to major depressive disorder (MDD) in adult samples, particularly in the lateral prefrontal, cingular and temporal regions. In contrast, neuroimaging investigations in adolescents with MDD are rare, although investigating young patients during a significant period of brain maturation might offer valuable insights into the neural mechanisms of MDD. We acquired perfusion images obtained with continuous arterial spin labelling in 21 medication-naive adolescents with MDD before and after a five-session cognitive behavioural group therapy (group CBT)...
March 21, 2017: Neuroreport
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#2
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28323841/detection-of-crossed-cerebellar-diaschisis-in-hyperacute-ischemic-stroke-using-arterial-spin-labeled-mr-imaging
#3
Koung Mi Kang, Chul-Ho Sohn, Seung Hong Choi, Keun-Hwa Jung, Roh-Eul Yoo, Tae Jin Yun, Ji-Hoon Kim, Sun-Won Park
BACKGROUND AND PURPOSE: Arterial spin-labeling (ASL) was recently introduced as a noninvasive method to evaluate cerebral hemodynamics. The purposes of this study were to assess the ability of ASL imaging to detect crossed cerebellar diaschisis (CCD) in patients with their first unilateral supratentorial hyperacute stroke and to identify imaging or clinical factors significantly associated with CCD. MATERIALS AND METHODS: We reviewed 204 consecutive patients who underwent MRI less than 8 hours after the onset of stroke symptoms...
2017: PloS One
https://www.readbyqxmd.com/read/28323181/perioperative-changes-in-cerebral-perfusion-territories-assessed-by-arterial-spin-labeling-magnetic-resonance-imaging-are-associated-with-postoperative-increases-in-cerebral-blood-flow-in-patients-with-carotid-stenosis
#4
Daisuke Yamamoto, Kohkichi Hosoda, Yoshito Uchihashi, Atsushi Fujita, Takashi Sasayama, Masahiko Fujii, Kazuro Sugimura, Masaaki Kohta, Eiji Kohmura
OBJECTIVE: MRI technique known as Territorial ASL (TASL) allows for noninvasive visualization of their perfusion territories. The objective of this study was to use TASL to assess the relationship between perioperative changes in the perfusion territories of ICA and CBF after carotid revascularization. METHODS: In 32 patients, ICA perfusion volume (PV) and CBF were measured before and after CEA/CAS using TASL and SPECT, respectively. ICA flow was measured during CEA before and after reconstruction, using an electromagnetic flowmeter...
March 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28323165/on-the-importance-of-modeling-fmri-transients-when-estimating-effective-connectivity-a-dynamic-causal-modeling-study-using-asl-data
#5
Martin Havlicek, Alard Roebroeck, Karl J Friston, Anna Gardumi, Dimo Ivanov, Kamil Uludag
Effective connectivity is commonly assessed using blood oxygenation level-dependent (BOLD) signals. In (Havlicek et al., 2015), we presented a novel, physiologically informed dynamic causal model (P-DCM) that extends current generative models. We demonstrated the improvements afforded by P-DCM in terms of the ability to model commonly observed neuronal and vascular transients in single regions. Here, we assess the ability of the novel and previous DCM variants to estimate effective connectivity among a network of five ROIs driven by a visuo-motor task...
March 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28321915/acceleration-of-asl-based-time-resolved-mr-angiography-by-acquisition-of-control-and-labeled-images-in-the-same-shot-actress
#6
Yuriko Suzuki, Noriyuki Fujima, Tetsuo Ogino, James Alastair Meakin, Akira Suwa, Hiroyuki Sugimori, Marc Van Cauteren, Matthias J P van Osch
PURPOSE: Noncontrast 4D-MR-angiography (MRA) using arterial spin labeling (ASL) is beneficial because high spatial and temporal resolution can be achieved. However, ASL requires acquisition of labeled and control images for each phase. The purpose of this study is to present a new accelerated 4D-MRA approach that requires only a single control acquisition, achieving similar image quality in approximately half the scan time. METHODS: In a multi-phase Look-Locker sequence, the first phase was used as the control image and the labeling pulse was applied before the second phase...
March 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28319118/functional-mri-for-characterization-of-renal-perfusion-impairment-and-edema-formation-due-to-acute-kidney-injury-in-different-mouse-strains
#7
Susanne Tewes, Faikah Gueler, Rongjun Chen, Marcel Gutberlet, Mi-Sun Jang, Martin Meier, Michael Mengel, Dagmar Hartung, Frank Wacker, Song Rong, Katja Hueper
PURPOSE: The purpose was to characterize acute kidney injury (AKI) in C57BL/6 (B6)- and 129/Sv (Sv)-mice by noninvasive measurement of renal perfusion and tissue edema using functional MRI. METHODS: Different severities of AKI were induced in B6- and Sv-mice by renal ischemia reperfusion injury (IRI). Unilateral clamping of the renal pedicle for 35 min (moderate AKI) or 45 min (severe AKI) was done. MRI (7-Tesla) was performed 1, 7 and 28 days after surgery using a flow alternating inversion recovery (FAIR) arterial spin labeling (ASL) sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28314796/prehypertensive-blood-pressures-and-regional-cerebral-blood-flow-independently-relate-to-cognitive-performance-in-midlife
#8
J Richard Jennings, Matthew F Muldoon, Christopher Ryan, H Michael Gach, Alicia Heim, Lei K Sheu, Peter J Gianaros
BACKGROUND: High blood pressure is thought to contribute to dementia in late life, but our understanding of the relationship between individual differences in blood pressure (BP) and cognitive functioning is incomplete. In this study, cognitive performance in nonhypertensive midlife adults was examined as a function of resting BP and regional cerebral blood flow (rCBF) responses during cognitive testing. We hypothesized that BP would be negatively related to cognitive performance and that cognitive performance would also be related to rCBF responses within areas related to BP control...
March 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28306210/benchmarking-transverse-spin-relaxation-based-oxygenation-measurements-in-the-brain-during-hypercapnia-and-hypoxia
#9
Wendy W Ni, Thomas Christen, Greg Zaharchuk
PURPOSE: To simultaneously assess reproducibility of three MRI transverse relaxation parameters ( R2', R2*, and R2 ) for brain tissue oxygenation mapping and to assess changes in these parameters with inhalation of gases that increase and decrease oxygenation, to identify the most sensitive parameter for imaging brain oxygenation. MATERIALS AND METHODS: Forty-eight healthy subjects (25 male, ages 35 ± 8 years) were scanned at 3.0 Tesla, each with one of four gases (mildly and strongly hypercapnic and hypoxic) administered in a challenge paradigm, using a gas delivery setup designed for patient use...
March 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28303317/evaluation-of-the-applicability-of-territorial-arterial-spin-labeling-in-meningiomas-for-presurgical-assessments-compared-with-3-dimensional-time-of-flight-magnetic-resonance-angiography
#10
Yiping Lu, Shihai Luan, Li Liu, Ji Xiong, Jianbo Wen, Jianxun Qu, Daoying Geng, Bo Yin
OBJECTIVES: To prospectively evaluate the application of territorial arterial spin labelling (t-ASL) in comparison with unenhanced three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) in the identification of the feeding vasculature of meningiomas. METHODS: Thirty consecutive patients with suspected meningiomas underwent conventional MR imaging, unenhanced 3D-TOF-MRA and t-ASL scanning. Four experienced neuro-radiologists assessed the feeding vessels with different techniques separately...
March 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28301491/the-performance-of-mr-perfusion-weighted-imaging-for-the-differentiation-of-high-grade-glioma-from-primary-central-nervous-system-lymphoma-a-systematic-review-and-meta-analysis
#11
Weilin Xu, Qun Wang, Anwen Shao, Bainan Xu, Jianmin Zhang
It is always a great challenge to distinguish high-grade glioma (HGG) from primary central nervous system lymphoma (PCNSL). We conducted a meta-analysis to assess the performance of MR perfusion-weighted imaging (PWI) in differentiating HGG from PCNSL. The heterogeneity and threshold effect were evaluated, and the sensitivity (SEN), specificity (SPE) and areas under summary receiver operating characteristic curve (SROC) were calculated. Fourteen studies with a total of 598 participants were included in this meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28295523/quantitative-susceptibility-mapping-based-cerebral-metabolic-rate-of-oxygen-mapping-with-minimum-local-variance
#12
Jingwei Zhang, Junghun Cho, Dong Zhou, Thanh D Nguyen, Pascal Spincemaille, Ajay Gupta, Yi Wang
PURPOSE: The objective of this study was to demonstrate the feasibility of a cerebral metabolic rate of oxygen (CMRO2 ) mapping method based on its minimum local variance (MLV) without vascular challenge using quantitative susceptibility mapping (QSM) and cerebral blood flow (CBF). METHODS: Three-dimensional multi-echo gradient echo imaging and arterial spin labeling were performed in 11 healthy subjects to calculate QSM and CBF. Minimum local variance was used to compute whole-brain CMRO2 map from QSM and CBF...
March 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28294455/integration-of-arterial-spin-labeling-into-stereotactic-radiosurgery-planning-of-cerebral-arteriovenous-malformations
#13
Onur Ozyurt, Alp Dincer, Mehmet Erdem Yildiz, Selcuk Peker, Meltem Yilmaz, Meric Sengoz, Cengizhan Ozturk
PURPOSE: To test whether the combined use of 4D arterial spin labeling angiography (4D ASL) and contrast-enhanced magnetic resonance angiography (4D CE-MRA) can work as a prospective alternative to digital subtraction angiography (DSA) for the delineation of the arteriovenous malformation (AVM) nidus in stereotactic radiosurgery (SRS) planning. MATERIALS AND METHODS: A custom 4D ASL sequence and a proof-of-concept software tool to integrate 4D ASL data to SRS planning were implemented...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28291957/effect-of-intranasally-administered-insulin-on-cerebral-blood-flow-and-perfusion-a-randomized-experiment-in-young-and-older-adults
#14
Abimbola A Akintola, Anna M van Opstal, Rudi G Westendorp, Iris Postmus, Jeroen van der Grond, Diana van Heemst
Insulin, a vasoactive modulator regulating peripheral and cerebral blood flow, has been consistently linked to aging and longevity. In this proof of principle study, using a randomized, double-blinded, placebo-controlled crossover design, we explored the effects of intranasally administered insulin (40IU) on cerebral blood flow (CBF) and perfusion in older (60-69 years, n=11) and younger (20-26 years, n=8) adults. Changes in CBF through the major cerebropetal arteries were assessed via phase contrast MR-angiography, and regional cortical tissue perfusion via pseudo-continuous arterial spin labelling...
March 14, 2017: Aging
https://www.readbyqxmd.com/read/28291816/identification-of-cerebral-perfusion-using-arterial-spin-labeling-in-patients-with-seizures-in-acute-settings
#15
Roh-Eul Yoo, Tae Jin Yun, Byung-Woo Yoon, Sang Kun Lee, Soon-Tae Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Sun-Won Park, Moon Hee Han
This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke seizure [n = 18], and seizure mimickers [n = 17]), were included in this retrospective study. Perfusion abnormality was analyzed for: (1) pattern, (2) multifocality, and (3) atypical distribution against vascular territories...
2017: PloS One
https://www.readbyqxmd.com/read/28281146/influence-of-the-cardiac-cycle-on-pcasl-cardiac-triggering-of-the-end-of-labeling
#16
Jasper Verbree, Matthias J P van Osch
OBJECTIVE: In arterial spin labeling (ASL), the cardiac cycle might adversely influence signal-stability by varying the amount of label created, labeling efficiency and/or transport times. Due to the long labeling duration in pseudo-Continuous ASL (pCASL), the blood labeled last contributes most to the ASLsignal. The present study investigated, using numerical simulations and in vivo experiments, the effect of the cardiac cycle on pCASL, thereby focusing on the end-of-labeling. MATERIALS AND METHODS: In the in vivo experiments the end-of-labeling was timed to a specific cardiac phase while a long labeling duration of >7 s was used to isolate the influence of the lastly labeled spins on ASL-signal stability...
March 9, 2017: Magma
https://www.readbyqxmd.com/read/28280105/measurement-of-the-distribution-of-ventilation-perfusion-ratios-in-the-human-lung-with-proton-mri-comparison-with-the-multiple-inert-gas-elimination-technique
#17
Rui Carlos Sá, Angela Cortney Henderson, Tatum S Simonson, Tatsuya J Arai, Harrieth Wagner, Rebecca J Theilmann, Peter D Wagner, Gordon Kim Prisk, Susan Roberta Hopkins
We have developed a novel functional proton magnetic resonance imaging (MRI) technique to measure regional ventilation-perfusion (VA/Q ) ratio in the lung. We conducted a comparison study of this technique in healthy subjects (n=7, age=42±16, Forced expiratory volume in 1 second=94% predicted), by comparing data measured using MRI to that obtained from the multiple inert gas elimination technique (MIGET). Regional ventilation measured in a sagittal lung slice using Specific Ventilation Imaging was combined with proton density measured using a fast gradient-echo sequence to calculate regional alveolar ventilation, registered with perfusion images acquired using arterial spin labeling, and divided on a voxel-by-voxel basis to obtain regional VA/Q ratio...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28277461/imaging-brain-collaterals-quantification-scoring-and-potential-significance
#18
Scott B Raymond, Pamela W Schaefer
Leptomeningeal collaterals provide the primary source of perfusion to ischemic brain tissue following the onset of acute ischemic stroke and are becoming an important imaging biomarker for stroke therapy triage. Collateral circulation is predictive of infarct growth, end infarct volume, and response to endovascular therapy. The strength of the collateral circulation varies among patients and is partially dependent on genetic and modifiable risk factors. Collateral circulation may be assessed by standard angiographic techniques, including digital subtraction angiography, computed tomography and magnetic resonance (MR) angiography, as well as a growing array of advanced MR techniques including arterial spin labeling and dynamic MR angiography...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28277457/advanced-mri-measures-of-cerebral-perfusion-and-their-clinical-applications
#19
Bryan Lanzman, Jeremy J Heit
Cerebral blood flow measurement by magnetic resonance imaging perfusion (MRP) techniques is broadly applied to patients with acute ischemic stroke, vasospasm following aneurysmal subarachnoid hemorrhage, chronic arterial steno-occlusive disease, cervical atherosclerotic disease, and primary brain neoplasms. MRP may be performed using an exogenous tracer, most commonly gadolinium-based intravenous contrast, or an endogenous tracer, such as arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). Here, we review the technical basis of commonly performed MRP techniques, the interpretation of MRP imaging maps, and how MRP provides valuable clinical information in the triage of patients with cerebral disease...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28271290/arterial-spin-labelling-detects-posterior-cortical-hypoperfusion-in-non-demented-patients-with-parkinson-s-disease
#20
Zoe Joanna Syrimi, Lubomir Vojtisek, Ilona Eliasova, Jana Viskova, Alena Svatkova, Jiri Vanicek, Irena Rektorova
While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years ± 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years ± 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software...
March 7, 2017: Journal of Neural Transmission
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