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https://www.readbyqxmd.com/read/28453560/caspase-polymorphisms-and-prognosis-of-hepatocellular-carcinoma
#1
Song Zhang, Qianyi Xiao, Zhuqing Shi, Guopeng Yu, Xiao-Pin Ma, Haitao Chen, Pengyin Zhang, Suqin Shen, He-Xi Ge Sai-Yin, Tao-Yang Chen, Pei-Xin Lu, Neng-Jin Wang, Weihua Ren, Peng Huang, Jun Xie, Carly Conran, S Lilly Zheng, Long Yu, Jianfeng Xu, De-Ke Jiang
The aim of our study was to determine the impact of genetic polymorphisms in the caspase (CASP) genes on prognosis of hepatocellular carcinoma (HCC). We genotyped 7 potentially functional polymorphisms in CASP3, CASP7, CASP8, CASP9, CASP10 genes in 362 HCC patients of receiving surgical resection of HCC tumor. The associations of genotype and haplotype with overall survival (OS) and disease free survival (DFS) were analyzed by using the Cox proportional hazards model. We found that the CASP9 rs4645981 C allele was significantly associated with positive effect on DFS (P = 0...
2017: PloS One
https://www.readbyqxmd.com/read/28453402/evaluation-of-carbon-emission-reductions-promoted-by-private-driving-restrictions-based-on-afc-data-in-beijing
#2
Wandi Zhang, Feng Chen, Zijia Wang, Jianling Huang, Bo Wang
Public transportation automatic fare collection (AFC) systems are able to continuously record large amounts of passenger travel information, providing massive, low-cost data for research on regulations pertaining to public transport. This data can be used not only to analyze characteristics of passengers' trips but also to evaluate transport policies that promote a travel mode shift and emission reduction. In this study, models combining card, survey, and GIS data are established with a research focus on the private driving restriction policies being implemented in an ever-increasing number of cities...
April 28, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28448928/potential-environmental-impact-of-bioethanol-production-chain-from-fiber-sorghum-to-be-used-in-passenger-cars
#3
Annachiara Forte, Amalia Zucaro, Massimo Fagnano, Angelo Fierro
A life cycle assessment (LCA) was applied to assess the environmental load of a prospective local bioethanol (EtOH) production system in Southern Italy by using lignocellulosic Fiber sorghum (FS) feedstock. A two steps analysis was carried out considering: (i) a "cradle-to-farm gate" LCA to investigate thoroughly the FS cultivation on hilly marginal land and (ii) a "cradle-to-wheels" system boundary encompassing the environmental pressure of the whole EtOH supply-use chain. Primary data related to lignocellulosic biomass production were combined with experimental feedstock conversion processes through advanced second generation technology...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448167/standardized-error-severity-score-ess-ratings-to-quantify-risk-associated-with-child-restraint-system-crs-and-booster-seat-misuse
#4
Christina M Rudin-Brown, Chelsea Kramer, Robin Langerak, Andrea Scipione, Shelley Kelsey
OBJECTIVE: Although numerous research studies have reported high levels of error and misuse of child restraint systems (CRS) and booster seats in experimental and real world scenarios, conclusions are limited because they provide little information regarding which installation issues pose the highest risk and thus should be targeted for change. Beneficial to legislating bodies and researchers alike would be a standardized, globally relevant, assessment of the potential injury risk associated with more common forms of CRS and booster seat misuse, which could be applied with observed error frequency, for example, in car seat clinics or during prototype user testing, to better identify and characterize the installation issues of greatest risk to safety...
April 27, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28447274/classification-and-regression-tree-model-for-predicting-tracheostomy-in-patients-with-traumatic-cervical-spinal-cord-injury
#5
Dae-Sang Lee, Chi-Min Park, Keumhee Chough Carriere, Joonghyun Ahn
PURPOSE: In patients with cervical spinal cord injury (CSCI), respiratory compromise and the need for tracheostomy are common. The purpose of this study was to identify common risk factors for tracheostomy following traumatic CSCI and develop a decision tree for tracheostomy in traumatic CSCI patients without pulmonary function test. METHODS: Data of 105 trauma patients with CSCI admitted in our institution from April, 2008 to February, 2014 were retrospectively analyzed...
April 26, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28446890/partial-visual-loss-affects-self-reports-of-hearing-abilities-measured-using-a-modified-version-of-the-speech-spatial-and-qualities-of-hearing-questionnaire
#6
Andrew J Kolarik, Rajiv Raman, Brian C J Moore, Silvia Cirstea, Sarika Gopalakrishnan, Shahina Pardhan
We assessed how visually impaired (VI) people perceived their own auditory abilities using an established hearing questionnaire, the Speech, Spatial, and Qualities of Hearing Scale (SSQ), that was adapted to make it relevant and applicable to VI individuals by removing references to visual aspects while retaining the meaning of the original questions. The resulting questionnaire, the SSQvi, assessed perceived hearing ability in diverse situations including the ability to follow conversations with multiple speakers, assessing how far away a vehicle is, and the ability to perceptually segregate simultaneous sounds...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28446684/nanoparticles-improve-economic-mileage-for-cars
#7
Miles A Miller
Targeted nanoparticles deliver chimeric antigen receptor genes to T cells in situ.
April 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28446180/physical-activity-when-riding-an-electric-assisted-bicycle
#8
Sveinung Berntsen, Lena Malnes, Aleksander Langåker, Elling Bere
BACKGROUND: The objectives of the present study were to compare time spent cycling, exercise intensity, and time spent in moderate- (MPA) and vigorous intensity physical activity (VPA) when cycling on an E-bike and a conventional bicycle on two "cycling-to-work" routes with differences in topography, defined as a hilly and a flat route. METHODS: Eight adults (23-54 years, two women) cycled outdoors on a conventional bicycle and an E-bike, on a flat (8.2 km) and a hilly (7...
April 26, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28445540/individuals-with-severely-impaired-vision-can-learn-useful-orientation-and-mobility-skills-in-virtual-streets-and-can-use-them-to-improve-real-street-safety
#9
Ellen Lambert Bowman, Lei Liu
Virtual reality has great potential in training road safety skills to individuals with low vision but the feasibility of such training has not been demonstrated. We tested the hypotheses that low vision individuals could learn useful skills in virtual streets and could apply them to improve real street safety. Twelve participants, whose vision was too poor to use the pedestrian signals were taught by a certified orientation and mobility specialist to determine the safest time to cross the street using the visual and auditory signals made by the start of previously stopped cars at a traffic-light controlled street intersection...
2017: PloS One
https://www.readbyqxmd.com/read/28445375/a-new-classification-of-three-dimensional-printing-technologies-systematic-review-of-three-dimensional-printing-for-patient-specific-craniomaxillofacial-surgery
#10
Carly A Jacobs, Alexander Y Lin
BACKGROUND: Three-dimensional printing technology has been advancing in surgical applications. This systematic review examines its patient-specific applications in craniomaxillofacial surgery. METHODS: Terms related to "three-dimensional printing" and "surgery" were searched on PubMed on May 4, 2015; 313 unique articles were returned. Inclusion and exclusion criteria concentrated on patient-specific surgical applications, yielding 141 full-text articles, of which 33 craniomaxillofacial articles were analyzed...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444774/protective-effect-of-l-carnitine-and-l-arginine-against-busulfan-induced-oligospermia-in-adult-rat
#11
A M Abd-Elrazek, O A H Ahmed-Farid
Busulfan is an anticancer drug caused variety of adverse effects for patients with cancer. But it could cause damage to the male reproductive system as one of its adverse effects. This study aimed to investigate the protective effect of L-carnitine and L-arginine on semen quality, oxidative stress parameters and testes cell energy after busulfan treatment. Adult male rats were divided into four groups: control (Con), busulfan (Bus), busulfan plus L-arginine (Bus + L-arg) and busulfan plus L-carnitine (Bus + L-car)...
April 25, 2017: Andrologia
https://www.readbyqxmd.com/read/28444440/paradoxical-undressing-associated-with-subarachnoid-hemorrhage-in-a-non-hypothermia-case
#12
Emilienne Descloux, Kewin Ducrot, Maria Pia Scarpelli, Alexander Lobrinus, Cristian Palmiere
Paradoxical undressing is a phenomenon characterizing some fatal hypothermia cases. The victims, despite low environmental temperatures, paradoxically remove their clothes due to a sudden feeling of warmth. In this report, we describe a case of suspected paradoxical undressing in a non-hypothermia case. The victim, a 51-year-old Caucasian man, was found dead wearing only sneakers and socks. All other clothing was found in his car. Postmortem investigations allowed the hypothesis of hypothermia to be ruled out and revealed the presence of a ruptured cerebral aneurysm that caused a subarachnoid hemorrhage, the latter responsible for the death...
April 25, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28443082/inbred-mouse-populations-exhibit-intergenerational-changes-in-intestinal-microbiota-composition-and-function-following-introduction-to-a-facility
#13
Jocelyn M Choo, Paul J Trim, Lex E X Leong, Guy C J Abell, Carly Brune, Nicole Jeffries, Steve Wesselingh, T N Dear, Marten F Snel, Geraint B Rogers
Inbred mice are used to investigate many aspects of human physiology, including susceptibility to disease and response to therapies. Despite increasing evidence that the composition and function of the murine intestinal microbiota can substantially influence a broad range of experimental outcomes, relatively little is known about microbiome dynamics within experimental mouse populations. We investigated changes in the intestinal microbiome between C57BL/6J mice spanning six generations (assessed at generations 1, 2, 3, and 6), following their introduction to a stringently controlled facility...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28442602/molecular-basis-of-metabolism-mediated-conversion-of-pk11195-from-an-antagonist-to-an-agonist-of-the-constitutive-androstane-receptor
#14
Bryan Mackowiak, Linhao Li, Matthew A Welch, Daochuan Li, Jace W Jones, Scott Heyward, Maureen A Kane, Peter W Swaan, Hongbing Wang
The constitutive androstane receptor (CAR) plays an important role in xenobiotic metabolism, energy homeostasis, and cell proliferation. Antagonism of CAR represents a key strategy for studying its function and may have potential clinical applications. However, specific human CAR (hCAR) antagonists are limited and conflicting data on the activity of these compounds have been reported. PK11195, a typical peripheral benzodiazepine receptor ligand, has been established as a potent hCAR deactivator in immortalized cells; whether it inhibits hCAR activity under physiologically-relevant conditions remains unclear...
April 25, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28442563/crossing-the-arterial-wall-with-cars
#15
Richard C Prince, Eric O Potma
No abstract text is available yet for this article.
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28441909/the-perceived-quality-of-in-vehicle-auditory-signals-a-structural-equation-modeling-approach
#16
Chia-Fen Chi, Ratna Sari Dewi, Yopie Yutama Surbakti, Dong-Yu Hsieh
The current study applied Structural Equation Modelling to analyze the relationship among pitch, loudness, tempo and timbre and their relationship with perceived sound quality. Twenty-eight auditory signals of horn, indicator, door open warning, and parking sensor were collected from 11 car brands. Twenty-one experienced drivers were recruited to evaluate all sound signals with 11 semantic differential scales. The results indicate that for the continuous sounds, pitch, loudness, and timbre each had a direct impact on the perceived quality...
April 25, 2017: Ergonomics
https://www.readbyqxmd.com/read/28441906/setting-priorities-for-eu-healthcare-workforce-it-skills-competence-improvement
#17
Sisi Li, Panagiotis D Bamidis, Stathis Th Konstantinidis, Vicente Traver, Josip Car, Nabil Zary
A major challenge for healthcare quality improvement is the lack of IT skills and knowledge of healthcare workforce, as well as their ambivalent attitudes toward IT. This article identifies and prioritizes actions needed to improve the IT skills of healthcare workforce across the EU. A total of 46 experts, representing different fields of expertise in healthcare and geolocations, systematically listed and scored actions that would improve IT skills among healthcare workforce. The Child Health and Nutrition Research Initiative methodology was used for research priority-setting...
April 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28441153/discharge-criteria-for-the-late-preterm-infant-a-review-of-the-literature
#18
Jenny M Quinn, Marteen Sparks, Sheila M Gephart
BACKGROUND: Standardized late preterm infant (LPI) discharge criteria ensure best practice and help guide the neonatal provider to determine the appropriate level of care following birth. However, the location can vary from the well newborn setting to the neonatal intensive care unit (NICU). PURPOSE: The purpose of this review is to examine differences in LPI discharge criteria between the well newborn setting and the NICU by answering the clinical questions, "What are the recommended discharge criteria for the LPI and do they differ if admitted to the well newborn setting versus the NICU?" SEARCH STRATEGY: Databases searched include CINAHL, TRIP, PubMed, and the Cochrane Library...
April 24, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28439067/perfluorooctanesulfonate-pfos-induced-sertoli-cell-injury-through-a-disruption-of-f-actin-and-microtubule-organization-is-mediated-by-akt1-2
#19
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M Lee, Dolores D Mruk, C Yan Cheng
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to be used in China and other developing countries as a global pollutant. Herein, using an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spatial expression of actin regulatory proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28437941/effect-of-scattering-on-coherent-anti-stokes-raman-scattering-cars-signals
#20
Janaka C Ranasinghesagara, Giuseppe De Vito, Vincenzo Piazza, Eric O Potma, Vasan Venugopalan
We develop a computational framework to examine the factors responsible for scattering-induced distortions of coherent anti-Stokes Raman scattering (CARS) signals in turbid samples. We apply the Huygens-Fresnel wave-based electric field superposition (HF-WEFS) method combined with the radiating dipole approximation to compute the effects of scattering-induced distortions of focal excitation fields on the far-field CARS signal. We analyze the effect of spherical scatterers, placed in the vicinity of the focal volume, on the CARS signal emitted by different objects (2μm diameter solid sphere, 2μm diameter myelin cylinder and 2μm diameter myelin tube)...
April 17, 2017: Optics Express
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