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https://www.readbyqxmd.com/read/28102168/brachial-plexus-root-avulsion-injury-with-occipital-condyle-fractures-case-study
#1
Alicja Baranowska, Joanna Baranowska, Agata Pydych, Paweł Baranowski
Avulsion injuries of the brachial plexus with occipital condyle fractures are very rare and usually result from motor vehicle accidents. This paper presents an analysis of the case of a 24-year-old male patient who sustained both these injuries in a car accident. Computed tomography revealed a fracture of the right occipital condyle and a magnetic resonance scan showed spinal nerve disruption at the C3-C7 level on the left. The patient underwent conservative treatment.
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102036/combining-one-step-sanger-sequencing-with-phasing-probe-hybridization-for-hla-class-i-typing-yields-rapid-g-group-resolution-predicting-99-of-unique-full-length-protein-sequences
#2
Bin Tu, Carly Masaberg, Lihua Hou, Daniel Behm, Peter Brescia, Nuri Cha, Kanthi Kariyawasam, Jar How Lee, Thoa Nong, John Sells, Paul Tausch, Ruyan Yang, Jennifer Ng, Carolyn Katovich Hurley
BACKGROUND: Sanger-based DNA sequencing of exons 2+3 of HLA class I alleles from a heterozygote frequently results in two or more alternative genotypes. This study was undertaken to reduce the time and effort required to produce a single high resolution HLA genotype. MATERIALS AND METHODS: Samples were typed in parallel by Sanger sequencing and oligonucleotide probe hybridization. This workflow, together with optimization of analysis software, was tested and refined during the typing of over 42,000 volunteers for an unrelated hematopoietic progenitor cell donor registry...
February 2017: HLA
https://www.readbyqxmd.com/read/28101795/locally-advanced-pancreatic-cancer-successfully-treated-by-distal-pancreatectomy-with-celiac-axis-resection-dp-car-after-s-1-with-radiation-therapy-followed-by-gemcitabine-nab-paclitaxel-therapy-a-case-report
#3
Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
BACKGROUND: The prognosis for pancreatic cancer remains dismal because many patients are diagnosed with unresectable cancer at the initial diagnosis. Recently, conversion surgery was reported as an effective treatment for initially unresectable pancreatic cancer with a favorable response to non-surgical treatment lasting over 240 days. Here, we describe a case of locally advanced pancreatic cancer (LAPC) successfully resected after treatment with S-1 and radiation followed by gemcitabine/nab-paclitaxel therapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28101283/group-active-engagements-using-quantitative-modeling-of-physiology-concepts-in-large-enrollment-biology-classes
#4
Karen L Carleton, Carly H Rietschel, Gili Marbach-Ad
No abstract text is available yet for this article.
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28101262/the-use-of-group-activities-in-introductory-biology-supports-learning-gains-and-uniquely-benefits-high-achieving-students
#5
Gili Marbach-Ad, Carly H Rietschel, Neeti Saluja, Karen L Carleton, Eric S Haag
This study describes the implementation and effectiveness of small-group active engagement (GAE) exercises in an introductory biology course (BSCI207) taught in a large auditorium setting. BSCI207 (Principles of Biology III-Organismal Biology) is the third introductory core course for Biological Sciences majors. In fall 2014, the instructors redesigned one section to include GAE activities to supplement lecture content. One section (n = 198) employed three lectures per week. The other section (n = 136) replaced one lecture per week with a GAE class...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28100838/car-t-cells-engage-in-anticancer-martial-arts
#6
Saar Gill
A clever redesign of the chimeric antigen receptor T cell concept turns a cancer-mediated immunosuppressive cytokine into a growth signal.
January 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28100832/reporter-gene-imaging-of-targeted-t-cell-immunotherapy-in-recurrent-glioma
#7
Khun Visith Keu, Timothy H Witney, Shahriar Yaghoubi, Jarrett Rosenberg, Anita Kurien, Rachel Magnusson, John Williams, Frezghi Habte, Jamie R Wagner, Stephen Forman, Christine Brown, Martin Allen-Auerbach, Johannes Czernin, Winson Tang, Michael C Jensen, Behnam Badie, Sanjiv S Gambhir
High-grade gliomas are aggressive cancers that often become rapidly fatal. Immunotherapy using CD8(+) cytotoxic T lymphocytes (CTLs), engineered to express both herpes simplex virus type 1 thymidine kinase (HSV1-TK) and interleukin-13 (IL-13) zetakine chimeric antigen receptor (CAR), is a treatment strategy with considerable potential. To optimize this and related immunotherapies, it would be helpful to monitor CTL viability and trafficking to glioma cells. We show that noninvasive positron emission tomography (PET) imaging with 9-[4-[(18)F]fluoro-3-(hydroxymethyl)butyl]guanine ([(18)F]FHBG) can track HSV1-tk reporter gene expression present in CAR-engineered CTLs...
January 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28099628/elevated-plasma-concentrations-of-s100-calcium-binding-protein-b-and-tumor-necrosis-factor-alpha-in-children-with-autism-spectrum-disorders
#8
Selin Aktan Guloksuz, Osman Abali, Esin Aktas Cetin, Sema Bilgic Gazioglu, Gunnur Deniz, Abdurrahman Yildirim, Ivana Kawikova, Sinan Guloksuz, James F Leckman
Objective: To investigate plasma concentrations of S100B (a calcium-binding protein derived primarily from the glia) and inflammatory cytokines in children with autism and the relationship between S100B and cytokine concentrations. Methods: Plasma levels of S100B, tumor necrosis factor alpha (TNF-α), interferon gamma, interleukin (IL)-1β, IL-4, IL-6, IL-10, and IL-17A were measured in 40 unmedicated children with autism and 35 normally developing healthy children...
January 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28099505/evaluation-of-6-and-10-year-old-child-human-body-models-in-emergency-events
#9
Laure-Lise Gras, Isabelle Stockman, Karin Brolin
Emergency events can influence a child's kinematics prior to a car-crash, and thus its interaction with the restraint system. Numerical Human Body Models (HBMs) can help understand the behaviour of children in emergency events. The kinematic responses of two child HBMs-MADYMO 6 and 10 year-old models-were evaluated and compared with child volunteers' data during emergency events-braking and steering-with a focus on the forehead and sternum displacements. The response of the 6 year-old HBM was similar to the response of the 10 year-old HBM, however both models had a different response compared with the volunteers...
2017: PloS One
https://www.readbyqxmd.com/read/28099004/nickel-mediated-decarbonylation-of-simple-unstrained-ketones-through-the-cleavage-of-carbon%C3%A2-carbon-bonds
#10
Toshifumi Morioka, Akihiro Nishizawa, Takayuki Furukawa, Mamoru Tobisu, Naoto Chatani
Despite advances in methods for the decarbonylation of aldehydes, the decarbonylation of ketones has met with limited success be-cause this process requires the activation of two inert carbon-carbon bonds. All of the decarbonylation reactions of simple unstained ketones reported to date require the addition of a stoichiometric rhodium complex. We report herein the nickel/N-heterocyclic car-bene-mediated decarbonylation of simple diary ketones. This reac-tion shows unique acceleration effects based on the presence of both electron-donating and electron-withdrawing groups...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28097353/clinical-guidelines-for-management-of-acne-vulgaris-reply
#11
Carly J Roman, Adam S Cifu, Sarah L Stein
No abstract text is available yet for this article.
January 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28095205/imperial-queerness-the-u-s-homophile-press-and-constructions-of-sexualities-in-asia-and-the-pacific-1953-1964
#12
Carly Simpson
This essay examines the ways in which U.S. homophile magazines represented and constructed Asia and the Pacific from 1953 to 1964. Through an analysis of 209 items that referenced Asia and the Pacific in ONE, Mattachine Review, and the Ladder, the essay argues that U.S. homophiles referenced the region in three primary ways: first, to create relationships, allies, and exchanges with people living in the region; second, to highlight the inferiority of the East and superiority of the West; and third, to reveal the cross-cultural and transhistorical nature of homosexuality...
January 17, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28095033/detection-of-the-toughest-pedestrian-injury-risk-as-a-smooth-function-of-age
#13
Tobias Niebuhr, Mirko Junge
OBJECTIVE: While it is common to regard age-specific groups (e.g. children, adults, elderly), smooth trends conditional on the age are mainly ignored in the literature. The present study examines the pedestrian injury risk in full-frontal pedestrian to passenger car accidents and incorporates the age -besides the collision speed and the injury severity- as a plug-in parameter. METHODS: Recent work introduced a model for pedestrian injury risk functions using explicit formulae with easily interpretable model parameters...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28095027/severe-and-extensive-traumatic-axonal-injury-following-minor-and-indirect-head-trauma
#14
Sung Ho Jang, Han Do Lee
OBJECTIVES: This study reports on a patient with mild traumatic brain injury (TBI) who showed severe and extensive traumatic axonal injury (TAI) of various neural tracts following minor and indirect head trauma, which was demonstrated by diffusion tensor tractography (DTT). CASE DESCRIPTION: A 26-year-old female patient suffered from indirect head trauma resulting from flexion-hyperextension injury after being hit from behind by a slowly moving car. At the time of head trauma, she felt tingling sensation on her four extremities; however, she did not experience loss of consciousness...
January 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28094575/treatment-approaches-of-hard-to-treat-non-hodgkin-lymphomas
#15
Lakshminarayanan Nandagopal, Amitkumar Mehta
Even after recent advancements with monoclonal antibodies, antibody drug conjugates and immune therapies, relapsed and refractory lymphomas remain challenging to treat; and the definition and treatment approaches of hard-to-treat lymphomas (HTL) continue to evolve. Areas covered: In this review, we will address HTL encompassing diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL) and peripheral T cell lymphomas (PTCL). DLBCL, which comprises 30-40% of non-Hodgkin lymphomas is a highly aggressive and heterogeneous malignancy, with primary refractory or relapsed disease remaining a therapeutic challenge...
January 17, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28094259/immunotherapy-glioblastoma-regression-obtained-with-car-t-cells
#16
Peter Sidaway
No abstract text is available yet for this article.
January 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28092813/walking-mechanics-for-patellofemoral-pain-subjects-with-similar-self-reported-pain-levels-can-differ-based-upon-neuromuscular-activation
#17
Matthew K Seeley, S Jun Son, Hyunsoo Kim, J Ty Hopkins
Patellofemoral pain (PFP) is often studied on subjects who are classified using only self-reported data. Neuromuscular activation influences movement mechanics for PFP subjects, but is not likely to be self-reported. We compared lower-extremity mechanics, during a common movement (walking), between two subdivisions of a group of PFP subjects that were similar, based on common self-report tools, but different, based on a common objective measure of quadriceps activation. Our intent was to highlight the importance of objectively considering neuromuscular activation when researching PFP movement mechanics...
January 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28091990/revaluation-of-stockpile-amount-of-pfos-containing-aqueous-film-forming-foam-in-japan-gaps-and-pitfalls-in-the-stockpile-survey
#18
Yasuyuki Zushi, Atsushi Yamamoto, Kiyotaka Tsunemi, Shigeki Masunaga
Stockpiles of perfluoro-octane sulfonic acid (PFOS) containing aqueous film-forming foam (AFFF) have the potential to be emitted by leaching, spills, and during use in fire response and other processes. Several studies have discussed the high levels of stockpiled PFOS-containing AFFF and the risk they pose to the environment; however, there are large gaps in the amounts in Japan compared with other countries. For example, 300 tons are stockpiled in Canada, 2200-2600 tons in Switzerland, 1400 tons in Norway, and 19,000 tons in Japan from their reports for publication...
January 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091394/a-simple-bio-inspired-vehicle-collision-detection-system
#19
Manfred Hartbauer
Modern cars are equipped with both active and passive sensor systems that can detect potential collisions. In contrast, locusts avoid collisions solely by responding to certain visual cues that are associated with object looming. In neurophysiological experiments, I investigated the possibility that "collision-detector neurons��� of locusts respond to impending collisions in films recorded with dashboard cameras of fast driving cars. In a complementary modelling approach, I developed a simple algorithm to reproduce the neuronal response that was recorded during object approach...
January 16, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28090317/all-trans-retinoic-acid-enhances-cytotoxic-effect-of-t-cells-with-an-anti-cd38-chimeric-antigen-receptor-in-acute-myeloid-leukemia
#20
Tetsumi Yoshida, Keichiro Mihara, Yoshifumi Takei, Kazuyoshi Yanagihara, Takanori Kubo, Joyeeta Bhattacharyya, Chihaya Imai, Tatsuji Mino, Yoshihiro Takihara, Tatsuo Ichinohe
We reported that T cells with anti-CD38-chimeric antigen receptors (CAR) eliminated B-cell lymphoma cells expressing CD38. To employ anti-CD38-CAR against acute myeloid leukemia (AML) blasts not expressing CD38, it is necessary to induce or increase the intensity of CD38 expression. A lactate dehydrogenase (LDH)-releasing assay and flow cytometry showed that anti-CD38-CAR T cells were cytotoxic against AML lines (THP-1 and CMK) expressing high CD38 levels (>99%), in time- and number of effector-dependent manners...
December 2016: Clinical & Translational Immunology
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