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https://www.readbyqxmd.com/read/29166735/-the-specific-cytotoxicities-of-chimeric-antigen-receptor-engineered-t-cells-on-different-lymphomas
#1
R Zhang, Q Deng, S N Sui, X Jin, M F Zhao
Objective: To investigate the specific cytotoxicities of the second and third generations of chimeric antigen receptor (CAR) -engineered T cells (CAR-T) on different lymphomas. Methods: CAR-Ts were prepared by lentivirus packaging and infection of T cells. CCK-8, ELISA and Lactate dehydrogenase cytotoxicity assay were applied to detect the proliferation capacity, the secretion level of inflammatory factor and the specific cytotoxicity. Flow cytometry assay showed the specific cytotoxicity and residual level of CAR-T in lymphomas of treated mice...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166726/-interaction-between-trpc1-and-stim1-in-calcium-sensing-receptor-mediated-calcium-influx-and-nitric-oxide-production-in-human-umbilical-vein-endothelial-cells
#2
L M Wang, H Zhong, N Tang, L J Pang, C J Zhang, F He
Objective: To investigate the interaction of Ca(2+) protein TRPC1 and STIM1 in extracellular Ca(2+) -sensing receptor (CaR)-induced extracellular Ca(2+) influx and the production of nitric oxide (NO). Methods: Human umbilical vein endothelial cells (HUVECs) were cultured and incubated with CaR agonist spermine (activating store-operates cation channels (SOC) and receptor-operated channels (ROC)), CaR negative allosteric modulator Calhex231 (blocking SOC, activating ROC) and ROC analogue TPA (activating ROC, blocking SOC), protein kinase C (PKC) inhibitor Ro31-8220, PKCs and PKCμ inhibitor Go6967(activate SOC, blocking ROC), respectively...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166240/more-on-anti-cd19-car-t-cells-in-cns-diffuse-large-b-cell-lymphoma
#3
(no author information available yet)
New England Journal of Medicine, Volume 377, Issue 21, Page 2101-2102, November 2017.
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29166068/pure-rotational-h2-thermometry-by-ultrabroadband-coherent-anti-stokes-raman-spectroscopy
#4
Trevor L Courtney, Alexis Bohlin, Brian D Patterson, Christopher J Kliewer
Coherent anti-Stokes Raman spectroscopy (CARS) is a sensitive technique for probing highly luminous flames in combustion applications to determine temperatures and species concentrations. CARS thermometry has been demonstrated for the vibrational Q-branch and pure-rotational S-branch of several small molecules. Practical advantages of pure-rotational CARS, such as multi-species detection, reduction of coherent line mixing and collisional narrowing even at high pressures, and the potential for more precise thermometry, have motivated experimental and theoretical advances in S-branch CARS of nitrogen (N2), for example, which is a dominant species in air-fed combustion processes...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165636/reducing-redundant-anaerobic-therapy-through-spaced-education-and-antimicrobial-stewardship-interventions
#5
Kelly B Flett, Athos Bousvaros, Jane Carpenter, Carly E Millrinen, Patricia Martin, Thomas J Sandora
Background: Decreasing the use of redundant anaerobic therapy is a key target for antimicrobial stewardship. Education techniques that optimize knowledge retention could be an important component of reducing these regimens. Methods: We implemented a quality improvement project that incorporated spaced education to reduce the use of redundant anaerobic therapy. The initial interventions (November through December 2015) included education in a hospital-wide newsletter and review of redundant anaerobic regimens by the antimicrobial stewardship program...
November 20, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29165122/decreased-blood-pressure-associated-with-in-vehicle-exposure-to-carbon-monoxide-in-korean-volunteers
#6
Geon-Woo Lee, Mun-Joo Bae, Ji-Yeon Yang, Jung-Woo Son, Jae-Lim Cho, Sang-Gyu Lee, Bo-Mi Jang, Hyun-Woo Lee, Jong-Soon Lim, Dong-Chun Shin, Young-Wook Lim
BACKGROUND: Carbon monoxide (CO) is one of the primary components of emissions from light-duty vehicles, and reportedly comprises 77% of all pollutants emitted in terms of concentration. Exposure to CO aggravates cardiovascular disease and causes other health disorders. The study was aimed to assess the negative effects by injecting different amounts of CO concentration directly to human volunteers boarding in the car. METHODS: Human volunteers were exposed to CO concentrations of 0, 33...
April 5, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164618/analysis-of-erythemal-uvb-dose-received-inside-a-car-in-valencia-spain
#7
Gonzalo Gurrea Ysasi, Vicente Blanca Giménez, Juan Carlos Moreno, MªAntonia Serrano
Continuous exposures to ultraviolet radiation can lead to harmful effects on human skin. Professional drivers may spend more than 8 hours per day inside a vehicle. This paper describes an analysis of the UVER (erythemal ultraviolet radiation) received by a driver and passenger inside a vehicle. A 3-door Peugeot 206 was used for the study. VioSpor Blue Line dosimeters (with a response profile close to that of human skin) were used to measure the erythematic dose of UV radiation (able to produce erythema on human skin)...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29163850/chimeric-antigen-receptor-t-car-t-cell-therapy-for-solid-tumors-challenges-and-opportunities
#8
REVIEW
An-Liang Xia, Xiao-Chen Wang, Yi-Jun Lu, Xiao-Jie Lu, Beicheng Sun
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have been shown to have unprecedented efficacy in B cell malignancies, most notably in B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate using anti-CD19 CAR-T cells. However, CAR T-cell therapy for solid tumors currently is faced with numerous challenges such as physical barriers, the immunosuppressive tumor microenvironment and the specificity and safety. The clinical results in solid tumors have been much less encouraging, with multiple cases of toxicity and a lack of therapeutic response...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163671/lignocellulose-binding-of-a-cel5a-rtcbm11-chimera-with-enhanced-%C3%AE-glucanase-activity-monitored-by-electron-paramagnetic-resonance
#9
Raquel Fonseca-Maldonado, Luana P Meleiro, Luís F S Mendes, Luana F Alves, Sibeli Carli, Lucas D Morero, Luis G M Basso, Antonio J Costa-Filho, Richard J Ward
Background: The Bacillus subtilis endo-β-1,4-glucanase (BsCel5A) hydrolyzes β-1,3-1,4-linked glucan, and the enzyme includes a family 3 carbohydrate-binding module (CBM3) that binds β-1,4-linked glucan. Methods: Here we investigate the BsCel5A β-1,3-1,4 glucanase activity after exchanging the CBM3 domain for the family 11 CBM from Ruminiclostridium thermocellum celH (RtCBM11) having β-1,3-1,4 glucan affinity. Results: The BsCel5A-RtCBM11 presents a 50...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29163278/can-limitations-of-visuospatial-attention-be-circumvented-a-review
#10
REVIEW
Basil Wahn, Peter König
In daily life, humans are bombarded with visual input. Yet, their attentional capacities for processing this input are severely limited. Several studies have investigated factors that influence these attentional limitations and have identified methods to circumvent them. Here, we provide a review of these findings. We first review studies that have demonstrated limitations of visuospatial attention and investigated physiological correlates of these limitations. We then review studies in multisensory research that have explored whether limitations in visuospatial attention can be circumvented by distributing information processing across several sensory modalities...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163083/effective-connectivity-analysis-of-the-brain-network-in-drivers-during-actual-driving-using-near-infrared-spectroscopy
#11
Zhian Liu, Ming Zhang, Gongcheng Xu, Congcong Huo, Qitao Tan, Zengyong Li, Quan Yuan
Driving a vehicle is a complex activity that requires high-level brain functions. This study aimed to assess the change in effective connectivity (EC) between the prefrontal cortex (PFC), motor-related areas (MA) and vision-related areas (VA) in the brain network among the resting, simple-driving and car-following states. Twelve young male right-handed adults were recruited to participate in an actual driving experiment. The brain delta [HbO2] signals were continuously recorded using functional near infrared spectroscopy (fNIRS) instruments...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29162191/childhood-adversity-moderates-the-influence-of-proximal-episodic-stress-on-the-cortisol-awakening-response-and-depressive-symptoms-in-adolescents
#12
Lisa R Starr, Kimberly Dienes, Catherine B Stroud, Zoey A Shaw, Y Irina Li, Fanny Mlawer, Meghan Huang
Childhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus-pituitary-adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates associations between recent episodic stress and (a) the cortisol awakening response (CAR), and (b) depressive symptoms, in 241 adolescents aged 14-17 years (cortisol n = 196)...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29160165/machine-learning-social-learning-and-the-governance-of-self-driving-cars
#13
Jack Stilgoe
Self-driving cars, a quintessentially 'smart' technology, are not born smart. The algorithms that control their movements are learning as the technology emerges. Self-driving cars represent a high-stakes test of the powers of machine learning, as well as a test case for social learning in technology governance. Society is learning about the technology while the technology learns about society. Understanding and governing the politics of this technology means asking 'Who is learning, what are they learning and how are they learning?' Focusing on the successes and failures of social learning around the much-publicized crash of a Tesla Model S in 2016, I argue that trajectories and rhetorics of machine learning in transport pose a substantial governance challenge...
November 1, 2017: Social Studies of Science
https://www.readbyqxmd.com/read/29159231/techno-economic-data-for-a-multi-model-approach-to-decarbonisation-of-the-irish-private-car-sector
#14
Eamonn Mulholland, Fionn Rogan, Brian P Ó Gallachóir
These data and analyses support the research article "From technology pathways to policy roadmaps to enabling measures - A multi-model approach" Mulholland et al. (2017) [1]. This article uses 3 models - an optimization model of the Irish energy system (Irish TIMES), a simulation model of the Irish private transport sector (CarSTOCK), and a market share algorithm used to provide a behavior rich representation into the multi-modelling process. Each of these models are linked to provide a technology pathway, policy roadmap, and finally identify the enabling measures of the private transport sector in a low-carbon Ireland moving toward 2050...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29159133/integration-of-novel-approaches-demonstrates-simultaneous-metabolic-inactivation-and-car-mediated-hepatocarcinogenesis-of-a-nitrification-inhibitor
#15
Jessica L LaRocca, Reza J Rasoulpour, B Bhaskar Gollapudi, David L Eisenbrandt, Lynea A Murphy, Matthew J LeBaron
Nitrapyrin, a nitrification inhibitor, produces liver tumors in mice at high doses. Several experiments were performed to investigate molecular, cellular, and apical endpoints to define the key events leading to the tumor formation. These data support a mode-of-action (MoA) characterized by constitutive androstane receptor (CAR) nuclear receptor activation, increased hepatocellular proliferation leading to hepatocellular foci and tumor formation. Specifically, nitrapyrin induced a dose-related increase in the Cyp2b10/CAR-associated transcript and protein...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29158765/usefulness-of-the-korean-developmental-screening-test-for-infants-and-children-for-the-evaluation-of-developmental-delay-in-korean-infants-and-children-a-single-center-study
#16
Chung-Hyuk Yim, Gun-Ha Kim, Baik-Lin Eun
Purpose: To evaluate the usefulness of the Korean Developmental Screening Test (K-DST) for infants and children for developmental delay assessment. Methods: This study was based on retrospective studies of the results of the K-DST, Preschool Receptive-Expressive Language Scale (PRES), Sequenced Language Scale for Infants (SELSI), Childhood Autism Rating Scale (CARS), Modified Checklist for Autism in Toddlers (M-CHAT), electroencephalography, magnetic resonance imaging, and extensive tests conducted in 209 of 1,403 patients, of whom 758 underwent the K-DST at the Korea University Guro Hospital between January 2015 and December 2016 and 645 were referred from local clinics between January 2015 and June 2016...
October 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29158532/recombinant-decorin-fusion-protein-attenuates-murine-abdominal-aortic-aneurysm-formation-and-rupture
#17
Yue Shen, Valerio Russo, Matthew R Zeglinski, Stephanie L Sellers, Zhengguo Wu, Cameron Oram, Stephanie Santacruz, Yulia Merkulova, Christopher Turner, Keerit Tauh, Hongyan Zhao, Tatjana Bozin, Lubos Bohunek, Haishan Zeng, Michael A Seidman, R Chris Bleackley, Bruce M McManus, Erkki Ruoslahti, Tero A H Järvinen, David J Granville
Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the vessel to rupture. Recombinant DCN fusion protein CAR-DCN was engineered with an extended C-terminus comprised of CAR homing peptide that recognizes inflamed blood vessels and penetrates deep into the vessel wall. In the present study, the role of systemically-administered CAR-DCN in AAA progression and rupture was assessed in a murine model...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158509/clinical-utility-of-the-prostate-health-index-phi-for-biopsy-decision-management-in-a-large-group-urology-practice-setting
#18
Jay White, B Vittal Shenoy, Ronald F Tutrone, Lawrence I Karsh, Daniel R Saltzstein, William J Harmon, Dennis L Broyles, Tamra E Roddy, Lori R Lofaro, Carly J Paoli, Dwight Denham, Mark A Reynolds
BACKGROUND: Deciding when to biopsy a man with non-suspicious DRE findings and tPSA in the 4-10 ng/ml range can be challenging, because two-thirds of such biopsies are typically found to be benign. The Prostate Health Index (phi) exhibits significantly improved diagnostic accuracy for prostate cancer detection when compared to tPSA and %fPSA, however only one published study to date has investigated its impact on biopsy decisions in clinical practice. METHODS: An IRB approved observational study was conducted at four large urology group practices using a physician reported two-part questionnaire...
November 20, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29158268/car-t-cell-therapies-in-glioblastoma-a-first-look
#19
Denis Migliorini, Pierre-Yves Dietrich, Roger Stupp, Gerald P Linette, Avery D Posey, Carl H June
Glioblastoma is an aggressive malignancy with a poor prognosis. The current standard of care for newly diagnosed glioblastoma patients includes surgery to the extent, temozolomide combined with radiotherapy, and alternating electric fields therapy. After recurrence, there is no standard therapy and survival is less than 9 months. Recurrent glioblastoma offers a unique opportunity to investigate new treatment approaches in a malignancy known for remarkable genetic heterogeneity, immunosuppressive microenvironment and partially permissive anatomical blood brain barrier (BBB)...
November 20, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29157826/modulation-of-pregnane-x-receptor-pxr-and-constitutive-androstane-receptor-car-activation-by-ursolic-acid-ua-attenuates-rifampin-isoniazid-cytotoxicity
#20
Hsiao-Yun Chang, Chao-Jung Chen, Wei-Chih Ma, Wai-Kok Cheng, Yen-Ning Lin, Ying-Ray Lee, Jih-Jung Chen, Yun-Ping Lim
BACKGROUND: Interactions between transcriptional inducers of cytochrome P450 (CYP450) enzymes and therapeutic drugs may be prevented by antagonizing the activation of a nuclear receptor (NR), pregnane X receptor (PXR, NR1I2), thus improving therapeutic efficacy. PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3)...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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