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Shi and Guangzhou

W T Wang, Q H Sun, J Qin, T T Li, X M Shi
Objective: To construct the air quality health index (AQHI) by inclusion of air pollutants PM(2.5) and O(3) in Guangzhou, Shanghai, Xi' an, Beijing, Shenyang, and explore scientificity and feasibility of its application in China. Methods: The daily average concentrations of PM(2.5) and O(3) in air, and daily average mortality from 2013 to 2015 in the 5 cities in China, the exposure-response coefficients of PM(2.5) and O(3) and total mortality from Meta studies in China were used to construct local AQHI. The health risk levels of air pollution in the 5 cities were calculated and compared with the characteristics of single pollutant concentrationof PM(2...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Yufeng Zhang, Xiaohan Du, Yurong Shi
The design characteristics of street canyons were investigated in Guangzhou in the hot-humid area of China, and the effects of the design factors and their interactions on pedestrian thermal comfort were studied by numerical simulations. The ENVI-met V4.0 (BASIC) model was validated by field observations and used to simulate the micrometeorological conditions and the standard effective temperature (SET) at pedestrian level of the street canyons for a typical summer day of Guangzhou. The results show that the micrometeorological parameters of mean radiant temperature (MRT) and wind speed play key roles in pedestrian thermal comfort...
February 14, 2017: International Journal of Biometeorology
Zhi-Rui Zhou, Min Liu, Hui-Rong Lu, Ye-Fei Li, Shi-Xiong Liang, Chun-Yan Zhang
There is no consensus on predicting prognosis for hepatocellular carcinoma patients undergoing radiotherapy. This study aims to evaluate the validity of different staging systems. Overall, 249 hepatocellular carcinoma patients were evaluated retrospectively. All patients were classified by different staging systems. The cumulative survival rates were calculated using the Kaplan-Meier method, and survival curves were compared using the log-rank test. Harrell's concordance index (c-index) was calculated. The 1-, 3-, and 5-year overall survival rates were 58%, 31% and 20%, respectively...
January 28, 2017: Oncotarget
Yong-Fa Zhang, Ming Shi, Rong-Ping Guo
BACKGROUND: Transarterial chemoembolisation (TACE) is still widely used to treat patients with advanced hepatocellular carcinoma who have no access to sorafenib in Asia. However, the indication of TACE for these patients has yet to be established. We established an objective point score to guide this decision in patients with advanced-stage hepatocellular carcinoma. METHODS: We developed a scoring system (MCCT score) based on preoperative data from a cohort of 422 patients receiving TACE as the first treatment for advanced hepatocellular carcinoma from 2006 to 2013 at Sun Yat-sen University Cancer Center, Guangzhou, China...
October 2016: Lancet
Lina Xiong, He Yan, Lei Shi, Ziyao Mo
The purpose of this study was to investigate the susceptibility of waterborne strains of Legionella to eight antimicrobials commonly used in legionellosis therapy. The minimum inhibitory concentrations (MICs) of 66 environmental Legionella strains, isolated from fountains and cooling towers of public facilities (hotels, schools, and shopping malls) in Macau and Guangzhou, were tested using the microdilution method in buffered yeast extract broth. The MIC50/MIC90 values for erythromycin, cefotaxime (CTX), doxycycline (DOC), minocycline (MIN), azithromycin, ciprofloxacin, levofloxacin (LEV), and moxifloxacin were 0...
December 2016: Journal of Water and Health
Hsin-I Tong, Wen Kang, Guangzhou Zhou, Min Liu, Yingli Shi, Yuanan Lu
This study was aimed to explore the potential of a non-invasive monocytes-based delivery system to transport therapeutic genes into the diseased brain. The study was conducted by first establishing the optimized conditions for lentiviral vector (LV)-mediated gene transfer into freshly isolated monocytes, followed by investigating the inflamed-brain homing efficiency and in vivo cell-mediated transgene expression by carrier monocytes in a mouse model with acute subregional neuroinflammation. Using a newly optimized spin-infection method, up to 35% of freshly isolated monocytes were successfully transduced with the LV system DHIV-101 at M...
November 18, 2016: Current Gene Therapy
Yongxia Shi, Shufen Li, Xiaobo Li, Kui Zheng, Shuai Yuan, Jicheng Huang
BACKGROUND: Dengue virus causes one of the most significant infectious diseases in tropical and subtropical regions, notable number of which is imported into China every year. RESULTS: In this study, the molecular epidemiologic and phylogenetic analyses of dengue cases imported into Guangzhou in South China during 2009-2013 were conducted. During that period, 46 imported dengue cases were identified, including four serotypes. Most of the dengue patients were travelling from Southeast Asia, South Asia and Africa...
2016: SpringerPlus
Qingwei Bu, Xiao Shi, Gang Yu, Jun Huang, Bin Wang, Jianbing Wang
Pharmaceuticals have been widely detected in the aquatic environment and demonstrated to be potential risks to humans and the environment. Understanding emission pathways of pharmaceuticals is essential to the control of pharmaceutical contamination for environmental management. The present study is aimed at testing the hypothesis that non-wastewater pathway is also significant to the emission of pharmaceuticals into the environment. To this end, we compared the actual production with the amount of 12 antibiotics obtained by back calculation from sewage concentrations in Beijing, Guangzhou and Chongqing...
December 2016: Chemosphere
Ning Zhong, Shunbin Shi, Hongzhen Wang, Guangzhou Wu, Yunliang Wang, Qiang Ma, Hongwei Wang, Yuanhua Liu, Jinzhi Wang
Aurora kinase A (AURKA) is an oncogenic serine/threonine kinase, it plays important roles in tumorigenesis and chemoresistance. In this study, we investigated the expression of AURKA in lung adenocarcinoma tissues, the role of small interference RNA targeting AURKA on growth, cell cycle, and apoptosis of lung adenocarcinoma cell lines in vitro. The AURKA is highly expressed in lung adenocarcinoma tissues and human lung adenocarcinoma cell lines. Lentivirus-mediated short hairpin RNA (shRNA) was used to knock down AURKA expression in human lung adenocarcinoma cell lines H1299 and A549...
September 2016: International Journal of Oncology
Xin Chen, Yuan Huang, Ping-Ping Guo, De-Sheng Ye, Li-Juan Xu, Shi-Ling Chen
OBJECTIVE: To determine the relationship between serum levels of the β-subunit of human chorionic gonadotropin (β-hCG) on day 24 of pregnancy during a frozen embryo transfer (FET) cycle and ongoing pregnancy. METHODS: In a retrospective cohort study, data were reviewed from women aged 38years or younger who underwent a FET cycle at Nanfang Hospital, Guangzhou, China, from January 2013 to December 2014. Inclusion criteria were use of hormone-replacement therapy to achieve an endometrial thickness of 8mm or more, and at least two surviving embryos...
September 2016: International Journal of Gynaecology and Obstetrics
Shi-yu Ma, Li-heng Guo, Yun Han, Jian Li, Min-zhou Zhang
As the largest research-oriented specialty department in national traditional Chinese medicine hospitals, the Department of Critical Care Medicine in Guangdong Provincial Hospital of Chinese Medicine insists on the development mode combined with clinical medicine and scientific research. By taking clinical and basic researches for integrative medicine preventing and treating acute myocardial in-farction and sepsis as a breakthrough, authors explored key problems of Chinese medicine in improving the prognosis related diseases and patients' quality of life...
April 2016: Chinese Journal of Integrated Traditional and Western Medicine
Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P Z Li, Geng Xu, Jianbo Shi, Qing-Ling Fu
BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS. METHODS: Data were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP(3)OS) document...
2016: Respiratory Research
Yingli Shi, Jianhai Xiang, Guangzhou Zhou, Tetsuzan Benny Ron, Hsin-I Tong, Wen Kang, Si Sun, Yuanan Lu
A newly isolated Pacific white shrimp (Litopenaeus vannamei) beta-actin promoter SbaP and its derivative compact construct SbaP (ENX) have recently been demonstrated to promote ectopic gene expression in vitro and in vivo. To further explore the potential transduction application, this newly isolated shrimp promoter SbaP was comparatively tested with cytomegalovirus (CMV), simian virus 40 (SV40), polyhedrin (Polh), and white spot syndrome virus immediate early gene 1 (WSSV ie1) four constitutive promoters and a beta-actin promoter (TbaP) from tilapia fish to characterize its promoting function in eight different cell lines...
June 2016: Marine Biotechnology
Guanghu Zhu, Jiming Liu, Qi Tan, Benyun Shi
BACKGROUND: Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpose of this study is to detect dengue transmission patterns and identify the disease dispersion dynamics in Guangzhou, China. METHODOLOGY: We conducted surveys in 12 districts of Guangzhou, and collected daily data of Breteau index (BI) and reported cases between September and November 2014 from the public health authority reports...
April 2016: PLoS Neglected Tropical Diseases
Xue-Yan Zheng, Min Qiu, Hui-Fang Chen, Shao-Wei Chen, Jian-Peng Xiao, Li-Na Jiang, Shu-Ting Huo, Ting-Li Shi, Li-Zhen Ma, Shan Liu, Jun-Hua Zhou, Qiong-Hua Zhang, Xing Li, Zhong Chen, Yi Wu, Jin-Ming Li, Wei-Jie Guan, Yi-Quan Xiong, Shu-Juan Ma, Xue-Shan Zhong, Jing Ge, Shu-Wen Cen, Qing Chen
Several novel adenoviruses (AdVs) have recently been identified in humans and other animal species. In this study, we report the molecular detection of and phylogenetically characterize bat and human AdVs detected in fecal or rectal swab samples collected in southern China. To detect AdVs, a 252-261 bp fragment of the DNA polymerase (DPOL) gene was amplified using nested PCR. A total of 520 rectal swab samples were collected from eight bat species in four geographic regions of southern China (Guangzhou, Yunfu, Huizhou, and Haikou city)...
June 2016: Vector Borne and Zoonotic Diseases
Lujun Shen, Wang Li, Siyang Wang, Guofeng Xie, Qi Zeng, Chen Chen, Feng Shi, Ying Zhang, Ming Wu, Wanhong Shu, Changchuan Pan, Yunfei Xia, Peihong Wu
Purpose To establish an image-based M1 category subdivision system for personalized prognosis prediction and treatment planning in patients with metastatic nasopharyngeal carcinoma (NPC). Materials and Methods A total of 1172 patients with metachronous metastasic NPC were retrospectively enrolled (the dataset is from Sun Yat-sen University Cancer Center for derivation, and the combined datasets are from Guangzhou Medical University Cancer Center and the Fifth Affiliated Hospital of Sun Yat-sen University for validation)...
September 2016: Radiology
Hui Su, Bo Zhao, Su-kun Zhang, Shan Liu, Ming-zhong Ren, Jie Li, Xiao-xia Shi
In order to investigate the internal exposure levels of polycyclic aromatic hydrocarbons (PAHs) in primary school students of Guangzhou, the research collected urine of 78 and 86 primary school students from two primary schools in the summer of 2014, one school located in the ordinary residential area and the other in the industrial area. The contents of 10 kinds of OH-PAHs were tested by the rapid liquid chromatography coupled to triple quadruple tandem mass spectrometry. The results showed that the concentrations of total OH-PAHs in primary school students in the residential zone ranged from 0...
December 2015: Huan Jing Ke Xue= Huanjing Kexue
Hsin-I Tong, Wen Kang, Yingli Shi, Guangzhou Zhou, Yuanan Lu
This study was designed to use superparamagnetic iron oxide nanoparticles (SPIONs) as evaluating tools to study monocyte-derived macrophages (MDM)-mediated delivery of small molecular agents into the diseased brains. MDM were tested with different-configured SPIONs at selected concentrations for their impacts on carrier cells' physiological and migratory properties, which were found to depend largely on particle size, coating, and treatment concentrations. SHP30, a SPION of 30-nm core size with oleic acids plus amphiphilic polymer coating, was identified to have high cellular uptake efficiency and cause little cytotoxic effects on MDM...
May 30, 2016: International Journal of Pharmaceutics
Chen Lidan, Li Linhai, Liao Yang, Sun Zhaohui, Huang Xiaoyan, Shi Yuling
This study aimed to investigate the molecular characteristics and antimicrobial susceptibility of Clostridium difficile clinical isolates in Guangzhou, China. One hundred twenty isolates were collected from Guangzhou General Hospital at the Guangzhou Military Command in China from March 2014 to April 2015, and 9 isolates were identified as tcdA-negative/tcdB-positive (A(-)B(+)) strains. Results showed that all of the strains were confirmed to be ST37 and 0 single nucleotide variants (SNVs) were found in the PaLoc region, and >60 SNVs were identified throughout the whole genome sequence...
April 2016: Diagnostic Microbiology and Infectious Disease
Yi Cao, Cheng Wang, Wenqi Shi, Yingying Zhu, Gengdong Chen, Yuming Chen
OBJECTIVE: To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and understand the relationship between NAFLD and metabolic risk factors in middle-aged and elderly adults. METHODS: This cross-sectional study recruited 2 935 subjects in Guangzhou, Guangdong province. Face-to-face interviews and laboratory analyses were conducted to collect general information and other covariates. Analysis of covariance and logistic regression analysis were performed to investigate the relationship between metabolic factors and the prevalence of NAFLD...
September 2015: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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