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https://www.readbyqxmd.com/read/27903224/evaluation-on-monocyte-mediated-delivery-of-a-therapeutic-gene-into-the-inflamed-brain
#1
Hsin-I Tong, Wen Kang, Guangzhou Zhou, Min Liu, Yingli Shi, Yuanan Lu
This study was aimed to explore the potential of a non-invasive monocytes-based delivery system to transport therapeutic genes into the diseased brain. The study was conducted by first establishing the optimized conditions for lentiviral vector (LV)-mediated gene transfer into freshly isolated monocytes, followed by investigating the inflamed-brain homing efficiency and in vivo cell-mediated transgene expression by carrier monocytes in a mouse model with acute subregional neuroinflammation. Using a newly optimized spin-infection method, up to 35% of freshly isolated monocytes were successfully transduced with the LV system DHIV-101 at M...
November 18, 2016: Current Gene Therapy
https://www.readbyqxmd.com/read/27722053/epidemiological-and-molecular-characterization-of-dengue-viruses-imported-into-guangzhou-during-2009-2013
#2
Yongxia Shi, Shufen Li, Xiaobo Li, Kui Zheng, Shuai Yuan, Jicheng Huang
BACKGROUND: Dengue virus causes one of the most significant infectious diseases in tropical and subtropical regions, notable number of which is imported into China every year. RESULTS: In this study, the molecular epidemiologic and phylogenetic analyses of dengue cases imported into Guangzhou in South China during 2009-2013 were conducted. During that period, 46 imported dengue cases were identified, including four serotypes. Most of the dengue patients were travelling from Southeast Asia, South Asia and Africa...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27681107/pay-attention-to-non-wastewater-emission-pathways-of-pharmaceuticals-into-environments
#3
Qingwei Bu, Xiao Shi, Gang Yu, Jun Huang, Bin Wang, Jianbing Wang
Pharmaceuticals have been widely detected in the aquatic environment and demonstrated to be potential risks to humans and the environment. Understanding emission pathways of pharmaceuticals is essential to the control of pharmaceutical contamination for environmental management. The present study is aimed at testing the hypothesis that non-wastewater pathway is also significant to the emission of pharmaceuticals into the environment. To this end, we compared the actual production with the amount of 12 antibiotics obtained by back calculation from sewage concentrations in Beijing, Guangzhou and Chongqing...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27571708/silencing-aurora-a-with-sirna-inhibits-cell-proliferation-in-human-lung-adenocarcinoma-cells
#4
Ning Zhong, Shunbin Shi, Hongzhen Wang, Guangzhou Wu, Yunliang Wang, Qiang Ma, Hongwei Wang, Yuanhua Liu, Jinzhi Wang
Aurora kinase A (AURKA) is an oncogenic serine/threonine kinase, it plays important roles in tumorigenesis and chemoresistance. In this study, we investigated the expression of AURKA in lung adenocarcinoma tissues, the role of small interference RNA targeting AURKA on growth, cell cycle, and apoptosis of lung adenocarcinoma cell lines in vitro. The AURKA is highly expressed in lung adenocarcinoma tissues and human lung adenocarcinoma cell lines. Lentivirus-mediated short hairpin RNA (shRNA) was used to knock down AURKA expression in human lung adenocarcinoma cell lines H1299 and A549...
September 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27346550/the-association-between-serum-%C3%AE-hcg-on-day-24-of-pregnancy-and-ongoing-pregnancy-in-frozen-embryo-transfer-cycles
#5
Xin Chen, Yuan Huang, Ping-Ping Guo, De-Sheng Ye, Li-Juan Xu, Shi-Ling Chen
OBJECTIVE: To determine the relationship between serum levels of the β-subunit of human chorionic gonadotropin (β-hCG) on day 24 of pregnancy during a frozen embryo transfer (FET) cycle and ongoing pregnancy. METHODS: In a retrospective cohort study, data were reviewed from women aged 38years or younger who underwent a FET cycle at Nanfang Hospital, Guangzhou, China, from January 2013 to December 2014. Inclusion criteria were use of hormone-replacement therapy to achieve an endometrial thickness of 8mm or more, and at least two surviving embryos...
September 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27323605/-construction-of-research-oriented-state-key-clinical-department-by-highlighting-the-characteris-tics-and-advantages-of-chinese-medicine
#6
Shi-yu Ma, Li-heng Guo, Yun Han, Jian Li, Min-zhou Zhang
As the largest research-oriented specialty department in national traditional Chinese medicine hospitals, the Department of Critical Care Medicine in Guangdong Provincial Hospital of Chinese Medicine insists on the development mode combined with clinical medicine and scientific research. By taking clinical and basic researches for integrative medicine preventing and treating acute myocardial in-farction and sepsis as a breakthrough, authors explored key problems of Chinese medicine in improving the prognosis related diseases and patients' quality of life...
April 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27184027/occupational-and-environmental-risk-factors-for-chronic-rhinosinusitis-in-china-a-multicentre-cross-sectional-study
#7
Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P Z Li, Geng Xu, Jianbo Shi, Qing-Ling Fu
BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS. METHODS: Data were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP(3)OS) document...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27177910/the-pacific-white-shrimp-%C3%AE-actin-promoter-functional-properties-and-the-potential-application-for-transduction-system-using-recombinant-baculovirus
#8
Yingli Shi, Jianhai Xiang, Guangzhou Zhou, Tetsuzan Benny Ron, Hsin-I Tong, Wen Kang, Si Sun, Yuanan Lu
A newly isolated Pacific white shrimp (Litopenaeus vannamei) beta-actin promoter SbaP and its derivative compact construct SbaP (ENX) have recently been demonstrated to promote ectopic gene expression in vitro and in vivo. To further explore the potential transduction application, this newly isolated shrimp promoter SbaP was comparatively tested with cytomegalovirus (CMV), simian virus 40 (SV40), polyhedrin (Polh), and white spot syndrome virus immediate early gene 1 (WSSV ie1) four constitutive promoters and a beta-actin promoter (TbaP) from tilapia fish to characterize its promoting function in eight different cell lines...
June 2016: Marine Biotechnology
https://www.readbyqxmd.com/read/27105350/inferring-the-spatio-temporal-patterns-of-dengue-transmission-from-surveillance-data-in-guangzhou-china
#9
Guanghu Zhu, Jiming Liu, Qi Tan, Benyun Shi
BACKGROUND: Dengue is a serious vector-borne disease, and incidence rates have significantly increased during the past few years, particularly in 2014 in Guangzhou. The current situation is more complicated, due to various factors such as climate warming, urbanization, population increase, and human mobility. The purpose of this study is to detect dengue transmission patterns and identify the disease dispersion dynamics in Guangzhou, China. METHODOLOGY: We conducted surveys in 12 districts of Guangzhou, and collected daily data of Breteau index (BI) and reported cases between September and November 2014 from the public health authority reports...
April 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27057618/molecular-detection-and-phylogenetic-characterization-of-bat-and-human-adenoviruses-in-southern-china
#10
Xue-Yan Zheng, Min Qiu, Hui-Fang Chen, Shao-Wei Chen, Jian-Peng Xiao, Li-Na Jiang, Shu-Ting Huo, Ting-Li Shi, Li-Zhen Ma, Shan Liu, Jun-Hua Zhou, Qiong-Hua Zhang, Xing Li, Zhong Chen, Yi Wu, Jin-Ming Li, Wei-Jie Guan, Yi-Quan Xiong, Shu-Juan Ma, Xue-Shan Zhong, Jing Ge, Shu-Wen Cen, Qing Chen
Several novel adenoviruses (AdVs) have recently been identified in humans and other animal species. In this study, we report the molecular detection of and phylogenetically characterize bat and human AdVs detected in fecal or rectal swab samples collected in southern China. To detect AdVs, a 252-261 bp fragment of the DNA polymerase (DPOL) gene was amplified using nested PCR. A total of 520 rectal swab samples were collected from eight bat species in four geographic regions of southern China (Guangzhou, Yunfu, Huizhou, and Haikou city)...
June 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27023116/image-based-multilevel-subdivision-of-m1-category-in-tnm-staging-system-for-metastatic-nasopharyngeal-carcinoma
#11
Lujun Shen, Wang Li, Siyang Wang, Guofeng Xie, Qi Zeng, Chen Chen, Feng Shi, Ying Zhang, Ming Wu, Wanhong Shu, Changchuan Pan, Yunfei Xia, Peihong Wu
Purpose To establish an image-based M1 category subdivision system for personalized prognosis prediction and treatment planning in patients with metastatic nasopharyngeal carcinoma (NPC). Materials and Methods A total of 1172 patients with metachronous metastasic NPC were retrospectively enrolled (the dataset is from Sun Yat-sen University Cancer Center for derivation, and the combined datasets are from Guangzhou Medical University Cancer Center and the Fifth Affiliated Hospital of Sun Yat-sen University for validation)...
September 2016: Radiology
https://www.readbyqxmd.com/read/27011995/-internal-exposure-levels-of-pahs-of-primary-school-students-in-guangzhou
#12
Hui Su, Bo Zhao, Su-kun Zhang, Shan Liu, Ming-zhong Ren, Jie Li, Xiao-xia Shi
In order to investigate the internal exposure levels of polycyclic aromatic hydrocarbons (PAHs) in primary school students of Guangzhou, the research collected urine of 78 and 86 primary school students from two primary schools in the summer of 2014, one school located in the ordinary residential area and the other in the industrial area. The contents of 10 kinds of OH-PAHs were tested by the rapid liquid chromatography coupled to triple quadruple tandem mass spectrometry. The results showed that the concentrations of total OH-PAHs in primary school students in the residential zone ranged from 0...
December 2015: Huan Jing Ke Xue= Huanjing Kexue
https://www.readbyqxmd.com/read/27001531/physiological-function-and-inflamed-brain-migration-of-mouse-monocyte-derived-macrophages-following-cellular-uptake-of-superparamagnetic-iron-oxide-nanoparticles-implication-of-macrophage-based-drug-delivery-into-the-central-nervous-system
#13
Hsin-I Tong, Wen Kang, Yingli Shi, Guangzhou Zhou, Yuanan Lu
This study was designed to use superparamagnetic iron oxide nanoparticles (SPIONs) as evaluating tools to study monocyte-derived macrophages (MDM)-mediated delivery of small molecular agents into the diseased brains. MDM were tested with different-configured SPIONs at selected concentrations for their impacts on carrier cells' physiological and migratory properties, which were found to depend largely on particle size, coating, and treatment concentrations. SHP30, a SPION of 30-nm core size with oleic acids plus amphiphilic polymer coating, was identified to have high cellular uptake efficiency and cause little cytotoxic effects on MDM...
May 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26867962/molecular-characterization-and-antimicrobial-susceptibility-of-tcda-negative-clostridium-difficile-isolates-from-guangzhou-china
#14
Chen Lidan, Li Linhai, Liao Yang, Sun Zhaohui, Huang Xiaoyan, Shi Yuling
This study aimed to investigate the molecular characteristics and antimicrobial susceptibility of Clostridium difficile clinical isolates in Guangzhou, China. One hundred twenty isolates were collected from Guangzhou General Hospital at the Guangzhou Military Command in China from March 2014 to April 2015, and 9 isolates were identified as tcdA-negative/tcdB-positive (A(-)B(+)) strains. Results showed that all of the strains were confirmed to be ST37 and 0 single nucleotide variants (SNVs) were found in the PaLoc region, and >60 SNVs were identified throughout the whole genome sequence...
April 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/26814862/-prevalence-and-metabolic-risk-factors-of-nonalcoholic-fatty-liver-disease-in-a-middle-aged-and-elderly-population-in-guangzhou
#15
Yi Cao, Cheng Wang, Wenqi Shi, Yingying Zhu, Gengdong Chen, Yuming Chen
OBJECTIVE: To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) and understand the relationship between NAFLD and metabolic risk factors in middle-aged and elderly adults. METHODS: This cross-sectional study recruited 2 935 subjects in Guangzhou, Guangdong province. Face-to-face interviews and laboratory analyses were conducted to collect general information and other covariates. Analysis of covariance and logistic regression analysis were performed to investigate the relationship between metabolic factors and the prevalence of NAFLD...
September 2015: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/26791959/relation-of-age-sex-and-bone-mineral-density-to-serum-25-hydroxyvitamin-d-levels-in-chinese-women-and-men
#16
Qiu-shi Wei, Zhen-qiu Chen, Xin Tan, Hai-rong Su, Xiao-xiang Chen, Wei He, Wei-min Deng
OBJECTIVE: To investigate the relation of circulating 25-hydroxyvitamin D (25[OH]D) levels to age, sex, and bone mineral density (BMD) in adults living in Guangzhou Province. METHODS: This cross-sectional study comprised 188 women and 122 men aged 17-88 years who were randomly sampled among community-dwelling Guangzhou residents. BMD at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry, and serum concentrations of 25(OH)D, parathyroid hormone (PTH), procollagen I N-terminal peptide, and beta C-telopeptide of collagen were assayed by electrochemiluminescence immunoassay...
November 2015: Orthopaedic Surgery
https://www.readbyqxmd.com/read/26701082/complete-genome-sequence-of-a-hepatitis-d-virus-genotype-1-strain-isolated-in-guangdong-china
#17
Baolin Liao, Weilie Chen, Qu Ping, Haiyan Shi, Haolan He, Huiyuan Liu, Yizhou Tan, Chunliang Lei, Weiping Cai
Here, we report the first complete genome sequence of a hepatitis D virus genotype 1 strain, GZ37, isolated in Guangzhou, Guangdong Province, China, in 2014. The sequence information provided here will help us understand the molecular epidemiology of hepatitis D virus and contribute to disease control in mainland China.
2015: Genome Announcements
https://www.readbyqxmd.com/read/26616048/community-health-centers-and-primary-care-access-and-quality-for-chronically-ill-patients-a-case-comparison-study-of-urban-guangdong-province-china
#18
Leiyu Shi, De-Chih Lee, Hailun Liang, Luwen Zhang, Marty Makinen, Nathan Blanchet, Ruth Kidane, Magnus Lindelow, Hong Wang, Shaolong Wu
OBJECTIVE: Reform of the health care system in urban areas of China has prompted concerns about the utilization of Community Health Centers (CHC). This study examined which of the dominant primary care delivery models, i.e., the public CHC model, the 'gate-keeper' CHC model, or the hospital-owned CHC models, was most effective in enhancing access to and quality of care for patients with chronic illness. METHODS: The case-comparison design was used to study nine health care organizations in Guangzhou, Dongguan, and Shenzhen cities within Guangdong province, China...
2015: International Journal for Equity in Health
https://www.readbyqxmd.com/read/26609035/relation-of-serum-25-hydroxyvitamin-d-levels-to-bone-mineral-density-in-southern-chinese-postmenopausal-women-a-preliminary-study
#19
Wei-Min Deng, Qiu-Shi Wei, Xin Tan, Yu Shao, Xian-Hong Chen, Wei-Shan Sun
BACKGROUND & OBJECTIVES: Vitamin D insufficiency is prevalent in postmenopausal women and has been related to low bone mineral density (BMD). However, controversial results have been reported for the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and BMD. This study was done to investigate whether serum 25(OH)D levels were associated with BMD in postmenopausal women living in Guangzhou in southern China. METHODS: This cross-sectional study involved 119 asymptomatic postmenopausal women, aged 48-85 yr, who were consecutively selected from Guangzhou city...
October 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/26507315/association-of-dietary-and-serum-vitamin-e-with-bone-mineral-density-in-middle-aged-and-elderly-chinese-adults-a-cross-sectional-study
#20
Wen-qi Shi, Jun Liu, Yi Cao, Ying-ying Zhu, Ke Guan, Yu-ming Chen
Previous studies have suggested that vitamin E (VE) may affect bone health, but the findings have been inconclusive. We examined the relationship between VE status (in both diet and serum) and bone mineral density (BMD) among Chinese adults. This community-based study included 3203 adults (2178 women and 1025 men) aged 40-75 years from Guangzhou, People's Republic of China. General and dietary intake information were collected using structured questionnaire interviews. The serum α-tocopherol (TF) level was quantified by reversed-phase HPLC...
January 14, 2016: British Journal of Nutrition
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