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Shi J

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https://www.readbyqxmd.com/read/29676029/functionalized-spiroindolines-with-anticancer-activity-through-a-metal-free-post-ugi-diastereoselective-one-pot-cascade-reaction
#1
Zhi-Gang Xu, Shi-Qiang Li, Jiang-Ping Meng, Dian-Yong Tang, Liu-Jun He, Jie Lei, Hui-Kuan Lin, Hong-Yu Li, Zhong-Zhu Chen
A post-Ugi diastereoselective one-pot cascade reaction requiring no metal catalyst was developed. The reaction scope was wide with mild conditions and good yields. A collection of spiroindolines was prepared by the protocol and screening tests in several difficult-to-inhibit cancer cell lines were conducted. The relationship of structure and anticancer activities was promising and in the Huh7 cell lines compound 16 j is more potent than Vinbalstine. The cyclization design strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like heterocycles...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29675921/clinical-and-molecular-insights-into-glanzmann-s-thrombasthenia-in-china
#2
L Zhou, M Jiang, H Shen, T You, Z Ding, Q Cui, Z Ma, F Yang, Z Xie, H Shi, J Su, L Cao, J Lin, J Yin, L Dai, H Wang, Z Wang, Z Yu, C Ruan, L Xia
Glanzmann's thrombasthenia (GT) is a rare bleeding disorder characterized by spontaneous mucocutaneous bleeding. The disorder is caused by quantitative or qualitative defects in integrin αIIbβ3 (encoded by ITGA2B and ITGB3) on the platelet and is more common in consanguineous populations. However, the prevalence rate and clinical characteristics of GT in nonconsanguineous populations have been unclear. We analyzed 97 patients from 93 families with GT in the Han population in China. This analysis showed lower consanguinity (18...
April 19, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29674416/altered-white-matter-microstructure-in-the-corpus-callosum-and-its-cerebral-interhemispheric-tracts-in-adolescent-idiopathic-scoliosis-diffusion-tensor-imaging-analysis
#3
C Xue, L Shi, S C N Hui, D Wang, T P Lam, C-B Ip, B K W Ng, J C Y Cheng, W C W Chu
BACKGROUND AND PURPOSE: Neural system was one of the important contributors to the etiopathogenesis of adolescent idiopathic scoliosis; additionally, the morphology of corpus callosum interconnecting both hemispheres of the brain was found to be altered morphologically. Our aim was to evaluate and compare the microstructural changes of the corpus callosum and its interhemispheric white matter fiber tracts interconnecting both cerebral hemispheres in patients with adolescent idiopathic scoliosis and matched controls using diffusion tensor imaging...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29673898/activation-of-liver-ampk-with-pf-06409577-corrects-nafld-and-lowers-cholesterol-in-rodent-and-primate-preclinical-models
#4
Ryan M Esquejo, Christopher T Salatto, Jake Delmore, Bina Albuquerque, Allan Reyes, Yuji Shi, Rob Moccia, Emily Cokorinos, Matthew Peloquin, Mara Monetti, Jason Barricklow, Eliza Bollinger, Brennan K Smith, Emily A Day, Chuong Nguyen, Kieran F Geoghegan, John M Kreeger, Alan Opsahl, Jessica Ward, Amit S Kalgutkar, David Tess, Lynne Butler, Norimitsu Shirai, Timothy F Osborne, Gregory R Steinberg, Morris J Birnbaum, Kimberly O Cameron, Russell A Miller
Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been proposed as a treatment for metabolic diseases; we show that the AMPK β1-biased activator PF-06409577 is capable of lowering hepatic and systemic lipid and cholesterol levels in both rodent and monkey preclinical models...
April 8, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29668916/extraintestinal-manifestations-in-vedolizumab-and-anti-tnf-treated-patients-with-inflammatory-bowel-disease
#5
Marla C Dubinsky, Raymond K Cross, William J Sandborn, Millie Long, Xue Song, Nianwen Shi, Yao Ding, Samantha Eichner, Brandee Pappalardo, Arijit Ganguli, Anthony Wang
Background: Extra-intestinal manifestations (EIMs) can impact morbidity in patients with inflammatory bowel diseases (IBD; Crohn's disease [CD] and ulcerative colitis [UC]). This study compared incidence rates of EIMs in patients with moderate to severe IBD receiving gut-selective vedolizumab (VDZ) vs those receiving systemic anti-tumor necrosis factor (anti-TNF) therapies. Methods: Adult IBD patients receiving VDZ or anti-TNFs were identified from the MarketScan claims database from September 28, 2012, through September 30, 2016...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29664337/pancreatic-stiffness-quantified-with-mr-elastography-relationship-to-postoperative-pancreatic-fistula-after-pancreaticoenteric-anastomosis
#6
Yu Shi, Ying Liu, Feng Gao, Yanqing Liu, Shengzhen Tao, Yue Li, Kevin J Glaser, Richard L Ehman, Qiyong Guo
Purpose To describe the relationship between conventional magnetic resonance (MR) imaging parameters and MR elastography of the pancreas in association with pancreatic histologic features and occurrence of postoperative pancreatic fistula (POPF). Materials and Methods Patients who underwent preoperative MR imaging (MR elastography and diffusion-, T1-, and T2-weighted imaging) followed by pancreatectomy with pancreaticoenteric anastomosis were included. The relationships between preoperative MR imaging parameters, demographic data, and intraoperative factors with POPF risk were analyzed with logistic regression analyses...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29663909/diagnosing-developmental-defects-of-enamel-pilot-study-of-online-training-and-accuracy
#7
Darya Dabiri, George J Eckert, Yihong Li, Kim Seow, Robert J Schroth, John Warren, J Timothy Wright, Shi Zhao, Margherita Fontana
PURPOSE: The purpose of this study was to assess dentists' ability to correctly identify and classify development defects of enamel (DDE). METHODS: The modified DDE (MDDE) index was used to classify enamel defects into two types: (1) enamel hypoplasia-pitted, grooved, or missing enamel; or (2) enamel opacity-translucency of enamel not caused by dental caries or fluorosis (can be either demarcated or diffuse). A panel of six experts selected and scored 36 images using the MDDE, and the consensus score was used as the gold standard score in the evaluation of survey respondents...
March 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29663577/t2-mapping-to-characterize-intestinal-fibrosis-in-crohn-s-disease
#8
Si-Yun Huang, Xue-Hua Li, Li Huang, Can-Hui Sun, Zhuang-Nian Fang, Meng-Chen Zhang, Jin-Jiang Lin, Meng-Jie Jiang, Ren Mao, Zi-Ping Li, Zhongwei Zhang, Shi-Ting Feng
BACKGROUND: Assessing bowel fibrosis in patients with Crohn's disease (CD) has important therapeutic implications. PURPOSE: To determine the utility of T2* mapping versus that of contrast enhanced (CE) imaging in grading intestinal fibrosis in patients with CD using surgical pathology as the reference standard. STUDY TYPE: Prospective. SPECIMENS: 102 specimens from 27 patients with CD. FIELD STRENGTH/SEQUENCE: 3...
April 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29659842/insights-into-the-pathogenesis-of-dominant-retinitis-pigmentosa-associated-with-a-d477g-mutation-in-rpe65
#9
Elliot H Choi, Susie Suh, Christopher L Sander, Christian J Ortiz Hernandez, Elizabeth R Bulman, Nimesh Khadka, Zhiqian Dong, Wuxian Shi, Krzysztof Palczewski, Philip D Kiser
RPE65 is the essential trans-cis isomerase of the classical retinoid (visual) cycle. Mutations in RPE65 give rise to severe retinal dystrophies, most of which are associated with loss of protein function and recessive inheritance. The only known exception is a c.1430G>A (D477G) mutation that gives rise to dominant retinitis pigmentosa with delayed onset and choroidal and macular involvement. Position 477 is distant from functionally critical regions of RPE65. Hence, the mechanism of D477G pathogenicity remains unclear, although protein misfolding and aggregation mechanisms have been suggested...
April 12, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29658313/metabonomic-analysis-of-toxic-action-of-long-term-low-level-exposure-to-acrylamide-in-rat-serum
#10
C Cao, H Shi, M Zhang, L Bo, L Hu, S Li, S Chen, S Jia, Y J Liu, Y L Liu, X Zhao, L Zhang
This study assessed the effects of long-term, low-dose acrylamide (AA) administration in rats using ultra-performance liquid chromatography-mass spectrometry. Forty male Wistar rats were randomly divided into the following four groups: control, low-dose AA (0.2 mg/kg BW), middle-dose AA (1 mg/kg BW), and high-dose AA (5 mg/kg BW). AA was administered to rats via drinking water ad libitum. After 16-week treatment, rat serum was collected for metabonomic analysis. Biochemical tests were further conducted to verify metabolic alterations...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29658100/excess-iron-stress-reduces-root-tip-zone-growth-through-nitric-oxide-mediated-repression-of-potassium-homeostasis-in-arabidopsis
#11
Lin Zhang, Guangjie Li, Meng Wang, Dongwei Di, Li Sun, Herbert J Kronzucker, Weiming Shi
The root tip zone is regarded as the principal action site for iron (Fe) toxicity and is more sensitive than other root zones, but the mechanism underpinning this remains largely unknown. We explored the mechanism underpinning the higher sensitivity at the Arabidopsis root tip and elucidated the role of nitric oxide (NO) using NO-related mutants and pharmacological methods. Higher Fe sensitivity of the root tip is associated with reduced potassium (K+ ) retention. NO in root tips is increased significantly above levels elsewhere in the root and is involved in the arrest of primary root tip zone growth under excess Fe, at least in part related to NO-induced K+ loss via SNO1 (sensitive to nitric oxide 1)/SOS4 (salt overly sensitive 4) and reduced root tip zone cell viability...
April 15, 2018: New Phytologist
https://www.readbyqxmd.com/read/29657099/design-synthesis-and-biological-evaluation-of-novel-4-phenylisoquinolinone-bet-bromodomain-inhibitors
#12
Michael J Bennett, Yiqin Wu, Amogh Boloor, Jennifer Matuszkiewicz, Shawn M O'Connell, Lihong Shi, Ryan K Stansfield, Joselyn R Del Rosario, James M Veal, David J Hosfield, Jiangchun Xu, Stephen W Kaldor, Jeffrey A Stafford, Juan M Betancort
The bromodomain and extra-terminal (BET) family of epigenetic proteins has attracted considerable attention in drug discovery given its involvement in regulating gene transcription. Screening a focused small molecule library based on the bromodomain pharmacophore resulted in the identification of 2-methylisoquinoline-1-one as a novel BET bromodomain-binding motif. Structure guided SAR exploration resulted in >10,000-fold potency improvement for the BRD4-BD1 bromodomain. Lead compounds exhibited excellent potencies in both biochemical and cellular assays in MYC-dependent cell lines...
April 10, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29656863/prevalence-of-functional-defecation-disorders-in-children-a-systematic-review-and-meta-analysis
#13
Ilan J N Koppen, Mana H Vriesman, Miguel Saps, Shaman Rajindrajith, Xiaoxia Shi, Faridi S van Etten-Jamaludin, Carlo Di Lorenzo, Marc A Benninga, Merit M Tabbers
OBJECTIVE: To systematically review the literature regarding the epidemiology of functional constipation and functional nonretentive fecal incontinence (FNRFI) in children. Secondary objectives were to assess the geographical, age, and sex distribution of functional constipation and FNRFI and to evaluate associated factors. STUDY DESIGN: The Cochrane Library, PubMed, and Embase databases were searched from 2006 until September 2017. The following inclusion criteria were applied: (1) prospective studies of population-based samples; (2) reporting on the prevalence of functional constipation or FNRFI according to the Rome III/IV criteria; (3) in children aged 0-18 years; and (4) published in full manuscript form...
April 12, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29655829/renal-effects-and-associated-outcomes-during-angiotensin-neprilysin-inhibition-in-heart-failure
#14
Kevin Damman, Mauro Gori, Brian Claggett, Pardeep S Jhund, Michele Senni, Martin P Lefkowitz, Margaret F Prescott, Victor C Shi, Jean L Rouleau, Karl Swedberg, Michael R Zile, Milton Packer, Akshay S Desai, Scott D Solomon, John J V McMurray
OBJECTIVES: The purpose of this study was to evaluate the renal effects of sacubitril/valsartan in patients with heart failure and reduced ejection fraction. BACKGROUND: Renal function is frequently impaired in patients with heart failure with reduced ejection fraction and may deteriorate further after blockade of the renin-angiotensin system. METHODS: In the PARADIGM-HF (Prospective Comparison of ARNI with ACE inhibition to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial, 8,399 patients with heart failure with reduced ejection fraction were randomized to treatment with sacubitril/valsartan or enalapril...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29652341/thermal-noise-limited-higher-order-mode-locking-of-a-reference-cavity
#15
X Y Zeng, Y X Ye, X H Shi, Z Y Wang, K Deng, J Zhang, Z H Lu
Higher-order mode locking has been proposed to reduce the thermal noise limit of reference cavities. By locking a laser to the HG02 mode of a 10-cm long all ultra-low expansion (ULE) cavity and measuring its performance with the three-cornered-hat method among three independently stabilized lasers, we demonstrate a thermal-noise-limited performance of a fractional frequency instability of 4.9×10-16 . The results match the theoretical models with higher-order optical modes. The achieved laser instability improves the all ULE short cavity results to a new low level...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29651132/compositional-characteristics-of-human-peripheral-trbv-pseudogene-rearrangements
#16
Bin Shi, Long Ma, Xiaoyan He, Peipei Wu, Peng Wang, Xiaomei Wang, Rui Ma, Xinsheng Yao
The diversity of the T cell receptor (TCR) complementarity determining region 3 (CDR3) repertoire is the result of random combinations, insertions and deletions during recombination of the germline V, D and J gene fragments. During evolution, some human TCR beta chain variable (TRBV) pseudogenes have been retained. Many previous studies have focused on functional TRBV genes, while little attention has been given to TRBV pseudogenes. To describe the compositional characteristics of TRBV pseudogene rearrangements, we compared and analysed TRBV pseudogenes, TRBV open reading frames (ORFs) and functional TRBV genes via high-throughput sequencing of DNA obtained from the peripheral blood of 4 healthy volunteers and 4 patients...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29644849/concurrent-cooperative-j-and-anti-cooperative-h-aggregates
#17
Kang Cai, Jiajun Xie, Di Zhang, Wenjing Shi, Qifan Yan, Dahui Zhao
Completely understanding the working mechanisms of sophisticated supramolecular self-assembly exhibiting competing paths is very important for chemists en route to acquiring the ability of constructing supramolecular systems with controlled structures and de-signed functions. Here, the self-aggregation behaviors of an N-heterocyclic aromatic dicarboximide molecule 1, boasting two compet-ing paths that give rise to different supramolecular structures and exhibit distinct thermodynamic features, are carefully examined...
April 12, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29643889/therapeutic-effects-of-visual-standard-channel-combined-with-f4-8-visual-puncture-super-mini-percutaneous-nephrolithotomy-on-multiple-renal-calculi
#18
Zhenyu Cui, Yanjun Gao, Wenzeng Yang, Chunli Zhao, Tao Ma, Xiaoqiang Shi
Objective: To evaluate the therapeutic effects of visual standard channel combined with F4.8 visual puncture super-mini percutaneous nephrolithotomy (SMP) on multiple renal calculi. Methods: The clinical data of 46 patients with multiple renal calculi treated in Affiliated Hospital of Hebei University from October 2015 to September 2016 were retrospectively analyzed. There were 28 males and 18 females aged from 25 to 65 years old, with an average of 42.6. The stone diameters were 3...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643533/-topoisomerase-inhibitor-upregulates-mica-b-expression-in-breast-cancer-cells-through-atm-atr-and-nf-%C3%AE%C2%BAb-pathway
#19
Y Zhu, Y J Shi, Y L Zhao, P Zhu
OBJECTIVE: To investigate the effects of chemotherapeutic agents widely used in clinical practice on major histocompatibility complex class I-related chain A and B (MICA/B) expression in breast cancer cells, and to explore the molecular mechanisms involved. METHODS: We examined MICA/B mRNA and surface protein expressions in breast cancer cells treated with chemotherapeutic agents by real-time RT-PCR and flow cytometry respectively. The blocking effects of ataxia telangiectasia mutated and Rad3-related kinase (ATM/ATR) inhibitor caffeine and nuclear factor κB (NF-κB) inhibitor pynolidine dithiocarbamate (PDTC) on etoposide-upregulated MICA/B mRNA and surface protein expressions were investigated...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29643531/-extraction-orthodontic-treatment-on-patients-with-chronicperiodontitis-a-preliminary-study
#20
Y W Zhang, T Y Xin, J Jiao, Y H Zhou, J Shi
OBJECTIVE: To retrospectively evaluate clinical and radiographic records of chronic periodontitis patients who underwent extraction-orthodontic treatment, in order to determine the effect of the treatment on probing depth, alveolar bone height of teeth adjacent to the extraction sites. METHODS: In the study, 33 chronic periodontitis patients who had finished extraction-orthodontic treatment were selected, the periodontal examination system tables and panoramic tomography were recorded before treatment (T0) and after treatment (T1), and the periodontal probing depth (PD), residual alveolar bone height (RBH) of the teeth adjacent to extraction sites (TAES) and the non-teeth adjacent to extraction sites (NTAES) were measured at T0 and T1...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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