keyword
MENU ▼
Read by QxMD icon Read
search

Shi J

keyword
https://www.readbyqxmd.com/read/29025734/dietary-copper-fructose-interactions-alter-gut-microbial-activity-in-male-rats
#1
Ming Song, Xiaohong Li, Xiang Zhang, Hongxue Shi, Miriam B Vos, Xiaoli Wei, Yuhua Wang, Hong Gao, Eric C Rouchka, Xinmin Yin, Zhanxiang Zhou, Russell A Prough, Matthew C Cave, Craig J McClain
Dietary copper-fructose interactions contribute to the development of nonalcoholic fatty liver disease (NAFLD). Gut microbiota play critical roles in the pathogenesis of NAFLD. The aim of this study was to determine the effect of different dietary doses of copper and their interactions with high fructose on gut microbiome. Male weanling Sprague-Dawley rats were fed diets with adequate copper (6 ppm, CuA), marginal copper (1.5 ppm, CuM) (low-copper) or supplemented copper (20 ppm, CuS) (high-copper) for 4 weeks...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29022970/ms-all-strategy-for-comprehensive-quantitative-analysis-of-pegylated-doxorubicin-peg-and-doxorubicin-by-lc-high-resolution-q-q-tof-mass-spectrometry-coupled-with-all-window-acquisition-of-all-fragment-ion-spectra
#2
Lei Yin, Chong Su, Tianming Ren, Xiangjun Meng, Meiyun Shi, J Paul Fawcett, Mengliang Zhang, Wei Hu, Jingkai Gu
The covalent attachment of polyethylene glycol (PEG) to therapeutic compounds (known as PEGylation) is one of the most promising techniques to improve the biological efficacy of small molecular weight drugs. After administration, PEGylated prodrugs can be metabolized into pharmacologically active compounds so that PEGylated drug, free drug and released PEG are present simultaneously in the body. Understanding the pharmacokinetic behavior of these three compounds is needed to guide the development of pegylated theranostic agents...
October 12, 2017: Analyst
https://www.readbyqxmd.com/read/29021267/association-of-neighborhood-socioeconomic-context-with-participation-in-cardiac-rehabilitation
#3
Justin M Bachmann, Shi Huang, Deepak K Gupta, Loren Lipworth, Michael T Mumma, William J Blot, Elvis A Akwo, Sunil Kripalani, Mary A Whooley, Thomas J Wang, Matthew S Freiberg
BACKGROUND: Cardiac rehabilitation (CR) is underutilized in the United States, with fewer than 20% of eligible patients participating in CR programs. Individual socioeconomic status is associated with CR utilization, but data regarding neighborhood characteristics and CR are sparse. We investigated the association of neighborhood socioeconomic context with CR participation in the SCCS (Southern Community Cohort Study). METHODS AND RESULTS: The SCCS is a prospective cohort study of 84 569 adults in the southeastern United States from 2002 to 2009, 52 117 of whom have Medicare or Medicaid claims...
October 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29021221/cancer-associated-fibroblasts-promote-directional-cancer-cell-migration-by-aligning-fibronectin
#4
Begum Erdogan, Mingfang Ao, Lauren M White, Anna L Means, Bryson M Brewer, Lijie Yang, M Kay Washington, Chanjuan Shi, Omar E Franco, Alissa M Weaver, Simon W Hayward, Deyu Li, Donna J Webb
Cancer-associated fibroblasts (CAFs) are major components of the carcinoma microenvironment that promote tumor progression. However, the mechanisms by which CAFs regulate cancer cell migration are poorly understood. In this study, we show that fibronectin (Fn) assembled by CAFs mediates CAF-cancer cell association and directional migration. Compared with normal fibroblasts, CAFs produce an Fn-rich extracellular matrix with anisotropic fiber orientation, which guides the cancer cells to migrate directionally...
October 11, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29021214/casein-kinase-ii-phosphorylation-of-cyclin-f-at-serine-621-regulates-the-lys48-ubiquitylation-e3-ligase-activity-of-the-scf-cyclin-f-complex
#5
Albert Lee, Stephanie L Rayner, Alana De Luca, Serene S L Gwee, Marco Morsch, Vinod Sundaramoorthy, Hamideh Shahheydari, Audrey Ragagnin, Bingyang Shi, Shu Yang, Kelly L Williams, Emily K Don, Adam K Walker, Katharine Y Zhang, Justin J Yerbury, Nicholas J Cole, Julie D Atkin, Ian P Blair, Mark P Molloy, Roger S Chung
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and muscle loss often resulting in patient death within 3-5 years of diagnosis. Recently, we identified disease-linked mutations in the CCNF gene, which encodes the cyclin F protein, in cohorts of patients with familial and sporadic ALS and frontotemporal dementia (FTD) (Williams KL et al 2016 Nat. Commun.7, 11253. (doi:10.1038/ncomms11253)). Cyclin F is a part of a Skp1-Cul-F-box (SCF) E3 ubiquitin-protein ligase complex and is responsible for ubiquitylating proteins for degradation by the proteasome...
October 2017: Open Biology
https://www.readbyqxmd.com/read/29020934/transcriptome-analyses-reveal-sr45-to-be-a-neutral-splicing-regulator-and-a-suppressor-of-innate-immunity-in-arabidopsis-thaliana
#6
Xiao-Ning Zhang, Yifei Shi, Jordan J Powers, Nikhil B Gowda, Chong Zhang, Heba M M Ibrahim, Hannah B Ball, Samuel L Chen, Hua Lu, Stephen M Mount
BACKGROUND: Regulation of pre-mRNA splicing diversifies protein products and affects many biological processes. Arabidopsis thaliana Serine/Arginine-rich 45 (SR45), regulates pre-mRNA splicing by interacting with other regulatory proteins and spliceosomal subunits. Although SR45 has orthologs in diverse eukaryotes, including human RNPS1, the sr45-1 null mutant is viable. Narrow flower petals and reduced seed formation suggest that SR45 regulates genes involved in diverse processes, including reproduction...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29019982/structural-phase-transition-in-monolayer-mote2-driven-by-electrostatic-doping
#7
Ying Wang, Jun Xiao, Hanyu Zhu, Yao Li, Yousif Alsaid, King Yan Fong, Yao Zhou, Siqi Wang, Wu Shi, Yuan Wang, Alex Zettl, Evan J Reed, Xiang Zhang
Monolayers of transition-metal dichalcogenides (TMDs) exhibit numerous crystal phases with distinct structures, symmetries and physical properties. Exploring the physics of transitions between these different structural phases in two dimensions may provide a means of switching material properties, with implications for potential applications. Structural phase transitions in TMDs have so far been induced by thermal or chemical means; purely electrostatic control over crystal phases through electrostatic doping was recently proposed as a theoretical possibility, but has not yet been realized...
October 11, 2017: Nature
https://www.readbyqxmd.com/read/29018341/recent-development-of-hydrogen-sulfide-releasing-stimulating-reagents-and-their-potential-applications-in-cancer-and-glycometabolic-disorders
#8
REVIEW
Chun-Tao Yang, Li Chen, Shi Xu, Jacob J Day, Xiang Li, Ming Xian
As an important endogenous gaseous signaling molecule, hydrogen sulfide (H2S) exerts various effects in the body. A variety of pathological changes, such as cancer, glycometabolic disorders, and diabetes, are associated with altered endogenous levels of H2S, especially decreased. Therefore, the supplement of H2S is of great significance for the treatment of diseases containing the above pathological changes. At present, many efforts have been made to increase the in vivo levels of H2S by administration of gaseous H2S, simple inorganic sulfide salts, sophisticated synthetic slow-releasing controllable H2S donors or materials, and using H2S stimulating agents...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29018331/distinctive-roles-for-%C3%AE-7-and-%C3%AE-9-nicotinic-acetylcholine-receptors-in-inflammatory-and-autoimmune-responses-in-the-murine-experimental-autoimmune-encephalomyelitis-model-of-multiple-sclerosis
#9
Qiang Liu, Paul Whiteaker, Barbara J Morley, Fu-Dong Shi, Ronald J Lukas
Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS). Other studies using knock-out (KO) mice have implicated nicotinic acetylcholine (ACh) receptors containing α7, α9, or β2 subunits (α7*-, α9*- or β2*-nAChR) in different, disease-exacerbating or disease-ameliorating processes. These outcomes are in harmony with gene expression analyses showing nAChR subunit mRNA in many classes of immune system cell types...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29016570/blinatumomab-induced-lineage-switch-of-b-all-with-t-4-11-q21-q23-kmt2a-aff1-into-an-aggressive-aml-pre-and-post-switch-phenotypic-cytogenetic-and-molecular-analysis
#10
C L Haddox, A A Mangaonkar, D Chen, M Shi, R He, J L Oliveira, M R Litzow, A Al-Kali, W J Hogan, M A Elliott
No abstract text is available yet for this article.
September 15, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28993611/natural-product-diversity-associated-with-the-nematode-symbionts-photorhabdus-and-xenorhabdus
#11
Nicholas J Tobias, Hendrik Wolff, Bardya Djahanschiri, Florian Grundmann, Max Kronenwerth, Yi-Ming Shi, Svenja Simonyi, Peter Grün, David Shapiro-Ilan, Sacha J Pidot, Timothy P Stinear, Ingo Ebersberger, Helge B Bode
Xenorhabdus and Photorhabdus species dedicate a large amount of resources to the production of specialized metabolites derived from non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS). Both bacteria undergo symbiosis with nematodes, which is followed by an insect pathogenic phase. So far, the molecular basis of this tripartite relationship and the exact roles that individual metabolites and metabolic pathways play have not been well understood. To close this gap, we have significantly expanded the database for comparative genomics studies in these bacteria...
October 9, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28993401/diagnosis-and-management-of-noncardiac-complications-in-adults-with-congenital-heart-disease-a-scientific-statement-from-the-american-heart-association
#12
REVIEW
George K Lui, Arwa Saidi, Ami B Bhatt, Luke J Burchill, Jason F Deen, Michael G Earing, Michael Gewitz, Jonathan Ginns, Joseph D Kay, Yuli Y Kim, Adrienne H Kovacs, Eric V Krieger, Fred M Wu, Shi-Joon Yoo
Life expectancy and quality of life for those born with congenital heart disease (CHD) have greatly improved over the past 3 decades. While representing a great advance for these patients, who have been able to move from childhood to successful adult lives in increasing numbers, this development has resulted in an epidemiological shift and a generation of patients who are at risk of developing chronic multisystem disease in adulthood. Noncardiac complications significantly contribute to the morbidity and mortality of adults with CHD...
October 9, 2017: Circulation
https://www.readbyqxmd.com/read/28992026/amino-acid-and-phosphorus-digestibility-of-fermented-corn-soybean-meal-mixed-feed-with-bacillus-subtilis-and-enterococcus-faecium-fed-to-pigs
#13
C Shi, Y Zhang, Y Yin, C Wang, Z Lu, F Wang, J Feng, Y Wang
In the present study, a 2-stage solid-state fermentation process using followed by was performed with the purpose of improving the nutritional quality of corn and soybean meal (SBM) mixed feed (MF). The matrix of native MF and fermented MF (FMF) was analyzed using scanning electron microscopy to determine external structures after solid-state fermentation. Results of the present study indicated that the FMF had a greater concentration of CP and total P compared with the unfermented feed, whereas the contents of β-conglycinin, glycinin, phytate P, raffinose, stachyose, and NDF in FMF declined by 77...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28988119/glucocorticoid-treatment-facilitates-development-of-a-metabolic-syndrome-in-ovariectomized-macaca-mulatta-fed-a-high-fat-diet
#14
Linzhao Li, Guang Yang, Guangneng Liao, Jie Mei, Lan Li, Chengshi Wang, Yujia Yuan, Yujun Shi, Jingping Liu, Zhihui Zhong, Jingqiu Cheng, Yanrong Lu, Iain J Clarke, Younan Chen
Metabolic syndrome (MetS) is characterized by a cluster of key features, which include abdominal obesity, insulin resistance, hypertension, and dyslipidemia. The aim of this study was to assess the impact of elevated glucocorticoid levels on the development of MetS in middle-aged female rhesus monkeys (Macaca Mulatta) after ovariectomy. Six female ovariectomized rhesus monkeys (9-13 years) were randomly assigned to either a control group (normal diet, n=3) or a group in which MetS was facilitated (n=3). The MetS group fed with HFD (15% fat) and received oral prednisone acetate treatment (50 mg/day)...
October 4, 2017: Steroids
https://www.readbyqxmd.com/read/28987381/altered-gene-expression-profiles-in-the-lungs-of-benzo-a-pyrene-exposed-mice-in-the-presence-of-lipopolysaccharide-induced-pulmonary-inflammation
#15
Q Shi, R R Fijten, D Spina, Y Riffo Vasquez, V M Arlt, R W Godschalk, F J Van Schooten
Patients with inflammatory lung diseases are often additionally exposed to polycyclic aromatic hydrocarbons like B[a]P and B[a]P-induced alterations in gene expression in these patients may contribute to the development of lung cancer. Mice were intra-nasally treated with lipopolysaccharide (LPS, 20μg/mouse) to induce pulmonary inflammation and subsequently exposed to B[a]P (0.5mg/mouse) by intratracheal instillation. Gene expression changes were analyzed in mouse lungs by RNA microarrays. Analysis of genes that are known to be involved in the cellular response to B[a]P indicated that LPS significantly inhibited gene expression of various enzymes linked to B[a]P metabolism, which was confirmed by phenotypic analyses of enzyme activity...
October 4, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28986646/differentiation-of-benign-and-malignant-solid-pancreatic-masses-using-magnetic-resonance-elastography-with-spin-echo-echo-planar-imaging-and-three-dimensional-inversion-reconstruction-a-prospective-study
#16
Yu Shi, Feng Gao, Yue Li, Shengzhen Tao, Bing Yu, Zaiyi Liu, Yanqing Liu, Kevin J Glaser, Richard L Ehman, Qiyong Guo
OBJECTIVES: To determine the diagnostic performance of MR elastography (MRE) and compare it with serum CA19-9 in differentiating malignant from benign pancreatic masses, with emphasis on differentiating between pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP). METHODS: We performed a prospective, consecutive, 24-month study in 85 patients with solid pancreatic masses confirmed by histopathologic examinations. The mass stiffness and stiffness ratio (calculated as the ratio of mass stiffness to the parenchymal stiffness) were assessed...
October 6, 2017: European Radiology
https://www.readbyqxmd.com/read/28984695/primary-cutaneous-cd8-t-cell-lymphoma-an-indolent-and-locally-aggressive-form-mimicking-paronychia
#17
Sarah M Beggs, Ben J Friedman, Davida Kornreich, Lauren Okon, Onder Alpdogan, Wenyin Shi, Joya Sahu
CD8 T-cell lymphomas comprise a wide spectrum of lymphomas, many which have yet to be formally classified. We present a case of a 43-year-old woman with an enlarging tumor distal to the distal interphalangeal joint of the fourth finger, compressing the underlying nail matrix. Magnetic resonance imaging showed bony involvement of the underlying distal phalanx. Histology showed a dense epidermotropic and pandermal infiltrate composed of medium-sized, uniformly pleomorphic lymphocytes with cleaved nuclei, which raised the possibility of primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28983557/role-of-deficient-dna-mismatch-repair-status-in-patients-with-stage-iii-colon-cancer-treated-with-folfox-adjuvant-chemotherapy-a-pooled-analysis-from-2-randomized-clinical-trials
#18
Aziz Zaanan, Qian Shi, Julien Taieb, Steven R Alberts, Jeffrey P Meyers, Thomas C Smyrk, Catherine Julie, Ayman Zawadi, Josep Tabernero, Enrico Mini, Richard M Goldberg, Gunnar Folprecht, Jean Luc Van Laethem, Karine Le Malicot, Daniel J Sargent, Pierre Laurent-Puig, Frank A Sinicrope
Importance: The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial. Objective: To determine the association of MMR status with disease-free survival (DFS) in patients with stage III colon cancer treated with FOLFOX. Design, Setting, and Participants: The evaluated biomarkers for MMR status were determined from prospectively collected tumor blocks from patients treated with FOLFOX in 2 open-label, phase 3 randomized clinical trials: NCCTG N0147 and PETACC8...
October 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28979090/effects-of-temperature-and-fluid-media-on-the-scroll-width-size-of-the-descemet-s-membrane-endothelial-keratoplasty-dmek-donor-graft
#19
Ellen H Koo, Allen O Eghrari, Ryan S Meshkin, Wei Shi, William J Feuer, Karen G DeMarco, Arthur C Kurz
AIM: Our study was conducted to evaluate whether higher temperature leads to increased - or wider - scroll widths of the Descemet's membrane endothelial keratoplasty (DMEK) donor graft. PURPOSE: To investigate the effects of temperature and fluid media on the DMEK donor graft scroll widths. MATERIALS AND METHODS: This research work was a laboratory investigation. Baseline cell count was taken via specular microscopy for the donor corneas at room temperature (20°C-25°C)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28976512/enhanced-blood-brain-barrier-permeability-and-glioblastoma-cell-targeting-via-thermoresponsive-lipid-nanoparticles
#20
M Rehman, A Madni, D Shi, A Ihsan, N Tahir, K R Chang, I Javed, T J Webster
Thermoresponsive targeting is used to deliver therapeutic agents at hyperthermic conditions (39-45 °C). However, available thermoresponsive drug delivery systems (TDDS), including liposomes, have a complex method of preparation involving toxic solvents and reagents. The objective of this in vitro study was to prepare and characterize thermoresponsive lipid nanoparticles (TLN) for treating glioblastoma, the most aggressive brain tumor whose treatment is limited by a low blood brain barrier (BBB) permeability of drugs...
October 4, 2017: Nanoscale
keyword
keyword
47784
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"