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https://www.readbyqxmd.com/read/28727518/therapeutic-and-prognostic-implications-of-braf-v600e-in-pediatric-low-grade-gliomas
#1
Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, Ofelia Cruz, Carmen de Torres, Cheng-Ying Ho, Roger J Packer, Ruth Tatevossian, Ibrahim Qaddoumi, Julie H Harreld, James D Dalton, Jean Mulcahy-Levy, Nicholas Foreman, Matthias A Karajannis, Shiyang Wang, Matija Snuderl, Amulya Nageswara Rao, Caterina Giannini, Mark Kieran, Keith L Ligon, Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, Alessandro Raso, Sabine Mueller, Theodore Nicolaides, Karen Silva, Romain Perbet, Alexandre Vasiljevic, Cécile Faure Conter, Didier Frappaz, Sarah Leary, Courtney Crane, Aden Chan, Ho-Keung Ng, Zhi-Feng Shi, Ying Mao, Elizabeth Finch, David Eisenstat, Bev Wilson, Anne Sophie Carret, Peter Hauser, David Sumerauer, Lenka Krskova, Valerie Larouche, Adam Fleming, Shayna Zelcer, Nada Jabado, James T Rutka, Peter Dirks, Michael D Taylor, Shiyi Chen, Ute Bartels, Annie Huang, David W Ellison, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E mutated PLGG (n = 99) were compared with a large international independent cohort of patients with BRAF V600E mutated-PLGG (n = 180)...
July 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28727234/kynurenine-a-tryptophan-metabolite-that-accumulates-with-age-induces-bone-loss
#2
Mona El Refaey, Meghan E McGee-Lawrence, Sadanand Fulzele, Eileen J Kennedy, Wendy B Bollag, Mohammed Elsalanty, Qing Zhong, Ke-Hong Ding, Nathaniel G Bendzunas, Xing-Ming Shi, Jianrui Xu, William D Hill, Maribeth H Johnson, Monte Hunter, Jessica L Pierce, Kanglun Yu, Mark W Hamrick, Carlos M Isales
Age-dependent bone loss occurs in humans and in several animal species, including rodents. The underlying causal mechanisms are probably multifactorial, although an age-associated increase in the generation of reactive oxygen species has been frequently implicated. We previously reported that aromatic amino acids function as antioxidants and are anabolic for bone and that they may potentially play a protective role in an aging environment. We hypothesized that upon oxidation the aromatic amino acids would not only lose their anabolic effects but also potentially become a catabolic byproduct...
July 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28726273/epigallocatechin-gallate-enhances-treatment-efficacy-of-oral-nifedipine-against-pregnancy-induced-severe-pre-eclampsia-a-double-blind-randomized-and-placebo-controlled-clinical-study
#3
D-D Shi, J-J Guo, L Zhou, N Wang
WHAT IS KNOWN AND OBJECTIVE: Oral nifedipine is commonly used to treat pre-eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre-eclampsia. METHODS: A total of 350 pregnant women with severe pre-eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG)...
July 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28724798/hepatic-jak2-protects-against-atherosclerosis-through-circulating-igf-1
#4
Tharini Sivasubramaniyam, Stephanie A Schroer, Angela Li, Cynthia T Luk, Sally Yu Shi, Rickvinder Besla, David W Dodington, Adam H Metherel, Alex P Kitson, Jara J Brunt, Joshua Lopes, Kay-Uwe Wagner, Richard P Bazinet, Michelle P Bendeck, Clinton S Robbins, Minna Woo
Atherosclerosis is considered both a metabolic and inflammatory disease; however, the specific tissue and signaling molecules that instigate and propagate this disease remain unclear. The liver is a central site of inflammation and lipid metabolism that is critical for atherosclerosis, and JAK2 is a key mediator of inflammation and, more recently, of hepatic lipid metabolism. However, precise effects of hepatic Jak2 on atherosclerosis remain unknown. We show here that hepatic Jak2 deficiency in atherosclerosis-prone mouse models exhibited accelerated atherosclerosis with increased plaque macrophages and decreased plaque smooth muscle cell content...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28724747/interleukin-1-receptor-in-seizure-susceptibility-after-traumatic-injury-to-the-pediatric-brain
#5
Bridgette D Semple, Terence J O'Brien, Kayleen Gimlin, David K Wright, Shi Eun Kim, Pablo M Casillas-Espinosa, Kyria M Webster, Steven Petrou, Linda J Noble-Haeusslein
Epilepsy after pediatric traumatic brain injury (TBI) is associated with poor quality of life. This study aimed to characterize post-traumatic epilepsy in a mouse model of pediatric brain injury, and to evaluate the role of interleukin-1 (IL-1) signaling as a target for pharmacological intervention. Male mice received a controlled cortical impact or sham surgery at postnatal day 21, approximating a toddler-aged child. Mice were treated acutely with an IL-1 receptor antagonist (IL-1Ra; 100 mg/kg s.c.) or vehicle...
July 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28721806/l-tetrahydropalmatine-induces-apoptosis-in-eu-4-leukemia-cells-by-down-regulating-x-linked-inhibitor-of-apoptosis-protein-and-increases-the-sensitivity-towards-doxorubicin
#6
S Li, D Chen, Renzhi Pei, Y Lu, P Zhang, J Ma, X Liu, X Du, K Sha, L Chen, J Cao, X Zhuang, J Wu, L Li, Z Fan, P Ye, S Tang, B Zhang, X Shi, K Li
BACKGROUND: L-Tetrahydropalmatine (L-THP) is a tetra-hydro protoberberine isoquinoline alkaloid. The phyto-compounds bearing isoquinoline alkaloids have been reported to show a potential effect against a number of human cancers cell lines including leukemia. We hypothesized that L-THP, being an isoquinoline alkaloid, could be a potential molecule against acute lymphoblastic leukemia (ALL), in this study, we evaluate L-THP against p53 deficient leukemia EU-4 cell lines in vitro. METHODS: For the study, p53 null leukemia EU-4 cells were used and treated with L-THP...
July 18, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28719231/biologic-injections-for-osteoarthritis-and-articular-cartilage-damage-can-we-modify-disease
#7
Weilong J Shi, Fotios P Tjoumakaris, Mayan Lendner, Kevin B Freedman
OBJECTIVE: The purpose of the present investigation is to conduct a systematic review of the literature to review the clinical results of platelet rich plasma (PRP) and mesenchymal stem cell treatments (MSC) (biologics) for articular cartilage lesions and osteoarthritis of the knee. METHODS: A search of the PubMed, EMBASE, and Cochrane databases was performed to identify studies involving biologic therapy for osteoarthritis or osteochondral defects. Only Level I-III clinical trials with at least 3-month follow-up were included...
July 18, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28719030/polygenic-risk-for-schizophrenia-and-neurocognitive-performance-in-patients-with-schizophrenia
#8
Shi-Heng Wang, Po-Chang Hsiao, Ling-Ling Yeh, Chih-Min Liu, Chen-Chung Liu, Tzung-Jeng Hwang, Ming H Hsieh, Yi-Ling Chien, Yi-Ting Lin, Sharon D Chandler, Stephen V Faraone, Nan Laird, Benjamin Neale, Steve A McCarroll, Stephen J Glatt, Ming T Tsuang, Hai-Gwo Hwu, Wei J Chen
Both neurocognitive deficits and schizophrenia are highly heritable. Genetic overlap between neurocognitive deficits and schizophrenia has been observed in both the general population and in clinical samples. This study aimed to examine if the polygenic architecture of susceptibility to schizophrenia modified neurocognitive performance in schizophrenia patients. Schizophrenia polygenic risk scores (PRS) were first derived from the Psychiatric Genomics Consortium (PGC) on schizophrenia, and then the scores were calculated in our independent sample of 1130 schizophrenia trios, who had PsychChip data and were part of the Schizophrenia Families from Taiwan project...
July 18, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28714960/bin1-reverses-pd-l1-mediated-immune-escape-by-inactivating-the-c-myc-and-egfr-mapk-signaling-pathways-in-non-small-cell-lung-cancer
#9
J Wang, Y Jia, S Zhao, X Zhang, X Wang, X Han, Y Wang, M Ma, J Shi, L Liu
Non-small cell lung cancer (NSCLC) is one of the most common and malignant carcinoma worldwide, and the incidence and mortality are increasing rapidly. Immunotherapy targeting programmed death 1/programmed death ligand 1 (PD-L1) signaling has shown prominent clinical effects in treating NSCLC; however, a poor understanding of the associated regulating molecular mechanisms of PD-L1 has become one of the biggest obstacles for further improving efficacy. Bridging integrator-1 (BIN1) can regulate numerous cancer-related molecules to exert multiple tumor-suppressing effects by either interacting or not interacting with c-MYC...
July 17, 2017: Oncogene
https://www.readbyqxmd.com/read/28714680/correction-to-discovery-of-pyrazolo-1-5-a-pyrimidine-b-cell-lymphoma-6-bcl6-binders-and-optimization-to-high-affinity-macrocyclic-inhibitors
#10
William McCoull, Roman D Abrams, Erica Anderson, Kevin Blades, Peter Barton, Matthew Box, Jonathan Burgess, Kate Byth, Qing Cao, Claudio Chuaqui, Rodrigo J Carbajo, Tony Cheung, Erin Code, Andrew D Ferguson, Shaun Fillery, Nathan O Fuller, Eric Gangl, Ning Gao, Matthew Grist, David Hargreaves, Martin R Howard, Jun Hu, Paul D Kemmitt, Jennifer E Nelson, Nichole O'Connell, D Bryan Prince, Piotr Raubo, Philip B Rawlins, Graeme R Robb, Junjie Shi, Michael J Waring, David Whittaker, Marta Wylot, Xiahui Zhu
No abstract text is available yet for this article.
July 17, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28709508/the-national-sleep-foundation-s-sleep-health-index
#11
Kristen L Knutson, Julie Phelan, Michael J Paskow, Anita Roach, Kaitlyn Whiton, Gary Langer, D Sunshine Hillygus, Michael Mokrzycki, William A Broughton, Sudhansu Chokroverty, Kenneth L Lichstein, Terri E Weaver, Max Hirshkowitz
OBJECTIVES: A validated survey instrument to assess general sleep health would be a useful research tool, particularly when objective measures of sleep are not feasible. Thus, the National Sleep Foundation spearheaded the development of the Sleep Health Index (SHI). DESIGN: The development of the SHI began with a task force of experts who identified key sleep domains and questions. An initial draft of the survey was created and questions were refined using cognitive testing and pretesting...
August 2017: Sleep Health
https://www.readbyqxmd.com/read/28709393/microbiome-associated-with-severe-caries-in-canadian-first-nations-children
#12
M Agnello, J Marques, L Cen, B Mittermuller, A Huang, N Chaichanasakul Tran, W Shi, X He, R J Schroth
Young Indigenous children in North America suffer from a higher degree of severe early childhood caries (S-ECC) than the general population, leading to speculation that the etiology and characteristics of the disease may be distinct in this population. To address this knowledge gap, we conducted the first microbiome analysis of an Indigenous population using modern molecular techniques. We investigated the caries-associated microbiome among Canadian First Nations children with S-ECC. Thirty First Nations children <72 mo of age with S-ECC and 20 caries-free children were recruited in Winnipeg, Canada...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28708422/epithelial-sodium-channel-enac-is-a-modifier-of-the-long-term-non-progressive-phenotype-associated-with-f508del-cftr-mutations
#13
Pankaj B Agrawal, Ruobing Wang, Hongmei Lisa Li, Klaus Schmitz-Abe, Chantelle Simone-Roach, Jingxin Chen, Jiahai Shi, Tin Louie, Shaohu Sheng, Meghan C Towne, Christine F Brainson, Michael A Matthay, Carla F Kim, Michael Bamshad, Mary J Emond, Norma P Gerard, Thomas R Kleyman, Craig Gerard
BACKGROUND: Cystic Fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability of clinical phenotype and survival, even among patients harboring the same genotype. We identified five CF patients with a homozygous F508del mutation in the CFTR gene living in their 5th or 6th decade of life, all with minimal change in lung function over longitudinal period of more than 20 years. Because of the rarity of this long-term non-progressive phenotype, we hypothesized those individuals may carry rare genetic variants in modifier genes that ameliorate disease severity...
July 14, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28708181/polarization-dependent-strong-coupling-between-surface-plasmon-polaritons-and-excitons-in-an-organic-dye-doped-nanostructure
#14
Kun Zhang, Tian-Yong Chen, Wen-Bo Shi, Cheng-Yao Li, Ren-Hao Fan, Qian-Jin Wang, Ru-Wen Peng, Mu Wang
In this work, we demonstrate polarization-dependent strong coupling between surface plasmon polaritons (SPPs) and excitons in the J-aggregates-attached aperture array. It is shown that the excitons strongly couple with the polarization-dependent SPPs, and Rabi splittings are consequently observed. As a result, the polarization-dependent polariton bands are generated in the system. Increasing the incident angle, the polaritons disperse to higher energies under transverse-electric illumination, while the polaritons disperse to lower energies under transverse-magnetic illumination...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28708157/complex-decorrelation-averaging-in-optical-coherence-tomography-a-way-to-reduce-the-effect-of-multiple-scattering-and-improve-image-contrast-in-a-dynamic-scattering-medium
#15
Lars Thrane, Shi Gu, Brecken J Blackburn, Kishore V Damodaran, Andrew M Rollins, Michael W Jenkins
We demonstrate that complex decorrelation averaging can reduce the effect of multiple scattering and improve optical coherence tomography (OCT) imaging contrast. Complex decorrelation averaging calculates the product of an A-scan and the complex conjugate of a subsequent A-scan. The resultant signal is the product of the amplitudes and the phase difference. All these resulting complex signals at a particular location are then averaged. We take advantage of the fact that complex averaging, in contrast to conventional magnitude averaging, is sensitive to phase decorrelation...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28705191/knowledge-and-understanding-of-health-insurance-challenges-and-remedies
#16
Andrew J Barnes, Yaniv Hanoch
As coverage is expanded in health systems that rely on consumers to choose health insurance plans that best meet their needs, interest in whether consumers possess sufficient understanding of health insurance to make good coverage decisions is growing. The recent IJHPR article by Green and colleagues-examining understanding of supplementary health insurance (SHI) among Israeli consumers-provides an important and timely answer to the above question. Indeed, their study addresses similar problems to the ones identified in the US health care market, with two notable findings...
July 13, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28704045/local-environment-of-terbium-iii-ions-in-layered-nanocrystalline-zirconium-iv-phosphonate-phosphate-ion-exchange-materials
#17
Maxwell W Terban, Chenyang Shi, Rita Silbernagel, Abraham Clearfield, Simon J L Billinge
The structures of Zr(IV) phosphonate-phosphate based, unconventional metal organic framework materials have been determined using atomic pair distribution function analysis of high energy, X-ray total scattering diffraction data. They are found to form as nanocrystalline layers of Zr phosphate, similar to the bulk, but with a high degree of interlayer disorder and intermediate intralayer order extending around 5 nm. These materials are of interest for their high selectivity for 3+ lanthanide ions. To investigate the mechanism of the selectivity, we utilize difference pair distribution function analysis to extract the local structural environment of Tb(3+) ions loaded into the framework...
July 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28703124/comparison-between-the-effects-of-hydrochlorothiazide-and-indapamide-on-the-kidney-in-hypertensive-patients-inadequately-controlled-with-losartan
#18
S Wang, J Li, X Zhou, K Liu, X Zhang, Q Meng, R Shi, D Shi, X Chen
The aim of the study is to compare the effects of hydrochlorothiazide and indapamide on the kidney in patients with hypertension inadequately controlled with losartan. A total of 140 patients who met the criteria and inadequately controlled with losartan 50 mg per day for 2 weeks were randomized in two groups and administered either hydrochlorothiazide 12.5 mg per day (n=70) or indapamide (sustained release) 1.5 mg per day (n=70) in combination with losartan 50 mg per day. Office blood pressure (BP) were collected at baseline and upon each follow-up visit...
July 13, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28703018/comparative-effectiveness-of-structural-versus-regulatory-protein-gene-transfer-on-articular-chondrocyte-matrix-gene-expression
#19
Shuiliang Shi, Congrong Wang, Albert Chan, Kashif Kirmani, George J Eckert, Stephen B Trippel
Objective The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes. Gene transfer may employ transgenes encoding regulatory factors that stimulate the production of matrix proteins, or may employ transgenes that encode the proteins themselves. The objective of this study was to determine which of these 2 approaches would be the better choice for further development. We compared these 2 approaches using the transgenes encoding the structural matrix proteins, aggrecan or type II collagen, and the transgene encoding the anabolic factor, insulin-like growth factor I (IGF-I)...
July 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28699174/inherited-variation-in-circadian-rhythm-genes-and-risks-of-prostate-cancer-and-three-other-cancer-sites-in-combined-cancer-consortia
#20
Fangyi Gu, Han Zhang, Paula L Hyland, Sonja Berndt, Susan M Gapstur, William Wheeler, Christopher I Amos, Stephane Bezieau, Heike Bickeböller, Hermann Brenner, Paul Brennan, Jenny Chang-Claude, David V Conti, Jennifer Ann Doherty, Stephen B Gruber, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, Richard S Houlston, Rayjean J Hung, Mark A Jenkins, Peter Kraft, Kate Lawrenson, James McKay, Sarah Markt, Lorelei Mucci, Catherine M Phelan, Conghui Qu, Angela Risch, Mary Anne Rossing, H-Erich Wichmann, Jianxin Shi, Eva Schernhammer, Kai Yu, Maria Teresa Landi, Neil E Caporaso
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)...
July 12, 2017: International Journal of Cancer. Journal International du Cancer
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