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https://www.readbyqxmd.com/read/27913632/intracellular-activation-of-complement-3-is-responsible-for-intestinal-tissue-damage-during-mesenteric-ischemia
#1
Abhigyan Satyam, Lakshmi Kannan, Naoya Matsumoto, Mayya Geha, Peter H Lapchak, Robin Bosse, Guo-Ping Shi, Jurandir J Dalle Lucca, Maria G Tsokos, George C Tsokos
Intestinal ischemia followed by reperfusion leads to local and remote organ injury attributed to inflammatory response during the reperfusion phase. The extent to which ischemia contributes to ischemia/reperfusion injury has not been thoroughly studied. After careful evaluation of intestinal tissue following 30 min of ischemia, we noticed significant local mucosal injury in wild-type mice. This injury was drastically reduced in C3-deficient mice, suggesting C3 involvement. Depletion of circulating complement with cobra venom factor eliminated, as expected, injury recorded at the end of the reperfusion phase but failed to eliminate injury that occurred during the ischemic phase...
December 2, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27912997/postacute-care-in-cancer-rehabilitation
#2
REVIEW
Ying Guo, Jack B Fu, Hong Guo, Jennifer Camp, Ki Y Shin, Shi-Ming Tu, Lynn J Palmer, Rajesh Yadav
Acute care is usually associated with disease progression, treatments for cancer, and medical comorbidities. Patients with cancer may develop sudden functional deficits that require rehabilitation. Some of these patients benefit from acute rehabilitation, others benefit from subacute rehabilitation. After acute rehabilitation, continuous care for these patients has not been well described. Three studies are presented to demonstrate that cancer rehabilitation is a continuous process. Rehabilitation professionals should know how to detect fall risk, monitor symptoms, and render symptom management...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27911046/verticillium-dahliae-lysm-effectors-differentially-contribute-to-virulence-on-plant-hosts
#3
Anja Kombrink, Hanna Rovenich, Xiaoqian Shi-Kunne, Eduardo Rojas-Padilla, Grardy C M van den Berg, Emmanouil Domazakis, Ronnie de Jonge, Dirk-Jan Valkenburg, Andrea Sánchez-Vallet, Michael F Seidl, Bart P H J Thomma
Chitin-binding LysM effectors contribute to virulence of various plant pathogenic fungi that are causal agents of foliar diseases. Here, we report on LysM effectors of the soil-borne fungal vascular wilt pathogen Verticillium dahliae. Comparative genomics revealed three core LysM effectors that are conserved in a collection of V. dahliae strains. Remarkably, and in contrast to the previously studied LysM effectors of other plant pathogens, no expression of core LysM effectors was monitored in planta in a taxonomically diverse panel of host plants...
December 2, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27910672/improved-spatial-calibration-for-the-cxrs-system-on-east
#4
X H Yin, Y Y Li, J Fu, D Jiang, S Y Feng, Y Q Gu, Y Cheng, B Lyu, Y J Shi, M Y Ye, B N Wan
A Charge eXchange Recombination Spectroscopy (CXRS) diagnostic system has been developed to measure profiles of ion temperature and rotation since 2014 on EAST. Several techniques have been developed to improve the spatial calibration of the CXRS diagnostic. The sightline location was obtained by measuring the coordinates of three points on each sightline using an articulated flexible coordinate measuring arm when the vessel was accessible. After vacuum pumping, the effect of pressure change in the vacuum vessel was evaluated by observing the movement of the light spot from back-illuminated sightlines on the first wall using the newly developed articulated inspection arm...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910662/a-novel-multi-channel-quadrature-doppler-backward-scattering-reflectometer-on-the-hl-2a-tokamak
#5
Zhongbing Shi, Wulu Zhong, Min Jiang, Zengchen Yang, Boyu Zhang, Peiwan Shi, Wei Chen, Jie Wen, Chengyuan Chen, Bingzhong Fu, Zetian Liu, Xuantong Ding, Qingwei Yang, Xuru Duan
A novel 16-channel fixed frequency Doppler backward scattering (DBS) reflectometer system has been developed on the HL-2A tokamak. This system is based on the filter-based feedback loop microwave source (FFLMS) technique, which has lower phase noise and lower power variation compared with present tunable frequency generation and comb frequency array generation techniques [J. C. Hillesheim et al. Rev. Sci. Instrum. 80, 083507 (2009) and W. A. Peebles et al. Rev. Sci. Instrum. 81, 10D902 (2010)]. The 16-channel DBS system is comprised of four × four-frequency microwave transmitters and direct quadrature demodulation receivers...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910627/bayesian-tomography-and-integrated-data-analysis-in-fusion-diagnostics
#6
Dong Li, Y B Dong, Wei Deng, Z B Shi, B Z Fu, J M Gao, T B Wang, Yan Zhou, Yi Liu, Q W Yang, X R Duan
In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910526/measurement-of-helium-like-and-hydrogen-like-argon-spectra-using-double-crystal-x-ray-spectrometers-on-east
#7
B Lyu, J Chen, R J Hu, F D Wang, Y Y Li, J Fu, Y C Shen, M Bitter, K W Hill, L F Delgado-Aparicio, N Pablant, S G Lee, M Y Ye, Y J Shi, B N Wan
A two-crystal assembly was deployed on the tangential X-ray crystal spectrometer to measure both helium-like and hydrogen-like spectra on EAST. High-quality helium-like and hydrogen-like spectra were observed simultaneously for the first time on one detector for a wide range of plasma parameters. Profiles of line-integrated core ion temperatures inferred from two spectra were consistent. Since tungsten was adopted as the upper divertor material, one tungsten line (W XLIV at 4.017 Å) on the short-wavelength side of the Lyman-α line (Lα1) was identified for typical USN discharges, which was diffracted by a He-like crystal (2d = 4...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910523/first-measurement-of-the-edge-charge-exchange-recombination-spectroscopy-on-east-tokamak
#8
Y Y Li, X H Yin, J Fu, D Jiang, S Y Feng, B Lyu, Y J Shi, Y Yi, X J Zhou, C D Hu, M Y Ye, B N Wan
An edge toroidal charge exchange recombination spectroscopy (eCXRS) diagnostic, based on a heating neutral beam injection (NBI), has been deployed recently on the Experimental Advanced Superconducting Tokamak (EAST). The eCXRS, which aims to measure the plasma ion temperature and toroidal rotation velocity in the edge region simultaneously, is a complement to the exiting core CXRS (cCXRS). Two rows with 32 fiber channels each cover a radial range from ∼2.15 m to ∼2.32 m with a high spatial resolution of ∼5-7 mm...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910481/measurement-of-the-electron-and-ion-temperatures-by-the-x-ray-imaging-crystal-spectrometer-on-joint-texas-experimental-tokamak
#9
W Yan, Z Y Chen, W Jin, S G Lee, Y J Shi, D W Huang, R H Tong, S Y Wang, Y N Wei, T K Ma, G Zhuang
An x-ray imaging crystal spectrometer has been developed on joint Texas experimental tokamak for the measurement of electron and ion temperatures from the Kα spectra of helium-like argon and its satellite lines. A two-dimensional multi-wire proportional counter has been applied to detect the spectra. The electron and ion temperatures have been obtained from the Voigt fitting with the spectra of helium-like argon ions. The profiles of electron and ion temperatures show the dependence on electron density in ohmic plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910444/synthetic-diagnostics-platform-for-fusion-plasmas-invited
#10
L Shi, E J Valeo, B J Tobias, G J Kramer, L Hausammann, W M Tang, M Chen
A Synthetic Diagnostics Platform (SDP) for fusion plasmas has been developed which provides state of the art synthetic reflectometry, beam emission spectroscopy, and Electron Cyclotron Emission (ECE) diagnostics. Interfaces to the plasma simulation codes GTC, XGC-1, GTS, and M3D-C(1) are provided, enabling detailed validation of these codes. In this paper, we give an overview of SDP's capabilities, and introduce the synthetic diagnostic modules. A recently developed synthetic ECE Imaging module which self-consistently includes refraction, diffraction, emission, and absorption effects is discussed in detail...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910372/far-forward-collective-scattering-measurements-by-fir-polarimeter-interferometer-on-j-text-tokamak
#11
P Shi, J Chen, L Gao, Y Liu, H Liu, Y N Zhou, G Zhuang
The multi-channel three-wave polarimeter-interferometer system on J-TEXT tokamak has been exploited to measure far-forward collective scattering from electron density fluctuations. The diagnostic utilizes far infrared lasers operated at 432 μm with 17-channel vertical chords (3 cm chord spacing), covering the entire cross section of plasma. Scattering laser power is measured using a high-sensitivity Schottky planar diode mixer which can also detect polarimetric and interferometric phase simultaneously. The system provides a line-integrated measurement of density fluctuations with maximum measurable wave number: k⊥max ≤ 2 cm(-1) and time response up to 350 kHz...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908347/prognostic-implications-of-changes-in-n-terminal-pro-b-type-natriuretic-peptide-in-patients-with-heart-failure
#12
Michael R Zile, Brian L Claggett, Margaret F Prescott, John J V McMurray, Milton Packer, Jean L Rouleau, Karl Swedberg, Akshay S Desai, Jianjian Gong, Victor C Shi, Scott D Solomon
BACKGROUND: Natriuretic peptides (NP) have prognostic value in heart failure (HF), although the clinical importance of changes in NP from baseline is unclear. OBJECTIVES: The authors assessed whether a reduction in N-terminal pro-B-type NP (NT-proBNP) was associated with a decrease in HF hospitalization and cardiovascular mortality (primary endpoint) in patients with HF and reduced ejection fraction, whether treatment with sacubitril/valsartan reduced NT-proBNP below specific partition values more than enalapril, and whether the relationship between changes in NT-proBNP and changes in the primary endpoint were dependent on assigned treatment...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27905023/distinct-cortical-and-sub-cortical-neurogenic-domains-for-gabaergic-interneuron-precursor-transcription-factors-nkx2-1-olig2-and-coup-tfii-in-early-fetal-human-telencephalon
#13
Ayman Alzu'bi, Susan Lindsay, Janet Kerwin, Shi Jie Looi, Fareha Khalil, Gavin J Clowry
The extent of similarities and differences between cortical GABAergic interneuron generation in rodent and primate telencephalon remains contentious. We examined expression of three interneuron precursor transcription factors, alongside other markers, using immunohistochemistry on 8-12 post-conceptional weeks (PCW) human telencephalon sections. NKX2.1, OLIG2, and COUP-TFII expression occupied distinct (although overlapping) neurogenic domains which extended into the cortex and revealed three CGE compartments: lateral, medial, and ventral...
November 30, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27903365/-hiv-drug-resistance-analysis-among-burmese-with-antiretroviral-treatment-in-dehong-prefecture-yunnan-province
#14
S T Yao, M Chen, Y L Li, R H Ye, J Yang, J B Wang, D D Cao, P Y Li, Y Shi, Y W Xu, W H Yang, C Y Yin, Y L Ma, S Duan
No abstract text is available yet for this article.
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27903362/-levels-of-dichlorodiphenyltrichloroethane-internal-exposure-levels-in-pregnant-women-of-xiamen-and-influencing-factors
#15
X S Yu, J He, J H Chen, Z B Lai, Y H Su, M M Shi, Z X Huang, Q J Cheng, X Y Ke, B H Zhao
Objective: To investigate the level of and factors influencing internal exposure to dichlorodiphenyltrichloroethane (DDT) in pregnant women. Methods: In all, 1 064 pregnant women were recruited in a hospital of Xiamen. Participants were asked to complete a questionnaire to obtain data on sociodemographic characteristics and lifestyle. Peripheral venous blood and cord blood samples were collected. Of the 1 064 pregnant women, 600 were enrolled in this study after completing the questionnaire and providing peripheral venous blood and cord blood...
November 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/27903341/-the-application-of-conscious-sedation-with-a-small-dose-of-dexmedetomidine-and-sufentanil-in-elderly-patients-undergoing-multiple-intestinal-polyps-resection
#16
C M Shi, Y D Zhou, M Xu, X D Wang, L M Meng, X J Liu, X Y Guo
Objective: To explore the effectiveness and feasibility of conscious sedation with a low dose of dexmedetomidine and sufentanil during multiple intestinal polyps resection in elderly patients. Methods: Sixty elderly patients who underwent multiple intestinal polyps resection in Peking University Third Hospital from Janurary to May 2016 were randomly divided into dexmedetomidine group (D group, n=30) and propofol group (P group, n=30). There were 28 males and 32 females with a mean age of (70.4±4.5) years old (range: 65-80 years old)...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27902857/quantitative-assessment-of-hyperacute-cerebral-infarction-with-intravoxel-incoherent-motion-mr-imaging-initial-experience-in-a-canine-stroke-model
#17
Qian-Qian Gao, Shan-Shan Lu, Xiao-Quan Xu, Cheng-Jiang Wu, Xing-Long Liu, Sheng Liu, Hai-Bin Shi
PURPOSE: To evaluate the feasibility of intravoxel incoherent motion (IVIM) for the measurement of diffusion and perfusion parameters in hyperacute strokes. MATERIALS AND METHODS: An embolic ischemic model was established with an autologous thrombus in 20 beagles. IVIM imaging was performed on a 3.0 Tesla platform at 4.5 h and 6 h after embolization. Ten b values from 0 to 900 s/mm(2) were fitted with a bi-exponential model to extract perfusion fraction f, diffusion coefficient D, and pseudo-diffusion coefficient D*...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27901018/the-signaling-axis-of-microrna-31-interleukin-25-regulates-th1-th17-mediated-inflammation-response-in-colitis
#18
T Shi, Y Xie, Y Fu, Q Zhou, Z Ma, J Ma, Z Huang, J Zhang, J Chen
Interleukin-25 (IL-25) is an important regulatory cytokine that has a key role on mucosal immune tolerance during inflammation response. However, the molecular mechanism that regulates the colonic IL-25 expression in Crohn's disease (CD) remains unclear. In this study, IL-25 level was proved to decrease in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice and IL-10 knockout (KO) spontaneous colitis mice. An inverse correlation between IL-25 and miR-31 was discovered in the colons from model mice and CD patients...
November 30, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27897363/gating-of-quantum-interference-in-molecular-junctions-by-heteroatom-substitution
#19
Xunshan Liu, Sara Sangtarash, David Reber, Dan Zhang, Hatef Sadeghi, Jia Shi, Zong-Yuan Xiao, Wenjing Hong, Colin J Lambert, Shi-Xia Liu
To guide the choice of future synthetic targets for single-molecule electronics, qualitative design rules are needed, which describe the effect of modifying chemical structure. Here the effect of heteroatom substitution on destructive quantum interference (QI) in single-molecule junctions is, for the first time experimentally addressed by investigating the conductance change when a "parent" meta-phenylene ethylene-type oligomer (m-OPE) is modified to yield a "daughter" by inserting one nitrogen atom into the m-OPE core...
November 29, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27897269/an-integrated-pharmacokinetic-pharmacogenomic-analysis-of-abcb1-and-slco1b1-polymorphisms-on-edoxaban-exposure
#20
A G Vandell, J Lee, M Shi, I Rubets, K S Brown, J R Walker
Edoxaban and its low-abundance, active metabolite M4 are substrates of P-glycoprotein (P-gp; MDR1) and organic anion transporter protein 1B1 (OATP1B1), respectively, and pharmacological inhibitors of P-gp and OATP1B1 can affect edoxaban and M4 pharmacokinetics (PK). In this integrated pharmacogenomic analysis, genotype and concentration-time data from 458 healthy volunteers in 14 completed phase 1 studies were pooled to examine the impact on edoxaban PK parameters of allelic variants of ABCB1 (rs1045642: C3435T) and SLCO1B1 (rs4149056: T521C), which encode for P-gp and OATP1B1...
November 29, 2016: Pharmacogenomics Journal
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