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https://www.readbyqxmd.com/read/28214148/muscle-characteristics-only-partially-explain-color-variations-in-fresh-hams
#1
K Stufft, J Elgin, B Patterson, S K Matarneh, R Preisser, H Shi, E M England, T L Scheffler, E W Mills, D E Gerrard
Fresh hams display significant lean color variation that persists through further processing and contributes to a less desirable cured product. In an attempt to understand the underlying cause of this color disparity, we evaluated the differences in muscle characteristics and energy metabolites across semimembranosus (SM) muscles differing in color variation. The L* (lightness) and a* (redness) values were highest and lowest (P<0.001), respectfully in the most caudal aspects of the muscle while the ultimate pH was the lowest (P<0...
December 24, 2016: Meat Science
https://www.readbyqxmd.com/read/28213972/promotion-of-cell-growth-and-adhesion-of-a-peptide-hydrogel-scaffold-via-mtor-cadherin-signaling
#2
Guojun Wei, Liping Wang, Daming Dong, Zhaowei Teng, Zuowei Shi, Kaifu Wang, Gang An, Ying Guan, Bo Han, Meng Yao, Cory J Xian
Understanding neurite outgrowth, orientation, and migration is important for the design of biomaterials that interface with the neural tissue. However, the molecular signaling alternations have not been well elucidated to explain the impact of hydrogels on cell morphology. In our previous studies, a silk fibroin peptide (SF16) hydrogel was found to be an effective matrix for the viability, morphology and proliferation of PC12 rat pheocrhomocytoma cells. We found that PC12 cells in the peptide hydrogel exhibited adhesive morphology compared to those cultured in agarose or collagen...
February 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28213930/antibiotic-administration-alleviates-the-aggravating-effect-of-orthodontic-force-on-ligature-induced-experimental-periodontitis-bone-loss-in-mice
#3
J Shi, Z Liu, T Kawai, Y Zhou, X Han
BACKGROUND AND OBJECTIVES: It is recognized that orthodontic force (OF) has an aggravating effect on the progression of destructive periodontitis if periodontitis have not been well controlled. However, the underlying mechanism is not completely clear. This study was to investigate the effect of antibiotic administration on OF-aggravated, ligature-induced experimental periodontitis in mice. MATERIAL AND METHODS: C57BL/6 mice (male, 8 wk old) were divided into three groups (n = 8)...
February 18, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28209037/-lung-function-influenced-the-prognosis-of-cardiac-surgery-in-patients-with-chronic-obstructive-pulmonary-disease
#4
C T Wu, J H Zhao, D Wei, Y X Shi, G F Zhu
Objective: To investigate the value of lung function for the prognosis of cardiac surgery in patients with chronic obstructive pulmonary disease(COPD). Methods: A retrospective analysis was conducted on the hospitalized patients with coronary heart disease or valvular heart disease in Beijing Anzhen hospital during Janury 2013 to December 2015. The relationship between lung function and extubation time, time of staying in ICU, second time tracheal incubation, tracheotomy and mortality rate were analyzed. Results: There were 355 patients without surgery in a total 1 729 of patients, of which 65 (18...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28207330/parent-centered-prevention-of-risky-behaviors-among-hispanic-youths-in-florida
#5
Yannine Estrada, Tae Kyoung Lee, Shi Huang, Maria I Tapia, Maria-Rosa Velázquez, Marcos J Martinez, Hilda Pantin, Manuel A Ocasio, Denise C Vidot, Lourdes Molleda, Juan Villamar, Bryan A Stepanenko, C Hendricks Brown, Guillermo Prado
OBJECTIVES: To evaluate the effectiveness of an evidence-based, parent-centered intervention, Familias Unidas, delivered by nonresearch personnel, in preventing substance use (alcohol, illicit drugs) and sex without a condom among Hispanic adolescents. METHODS: A randomized controlled trial (n = 746) evaluated the effectiveness of Familias Unidas among Hispanic eighth graders (age range = 12-16 years), relative to prevention as usual, within a public school system...
February 16, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28205277/preliminary-evaluation-of-altered-brain-microstructure-in-the-emotion-cognition-region-in-children-with-haemophilia-a-a-diffusional-kurtosis-imaging-study
#6
D Hu, H Kang, Y Lv, N Zhang, L Tang, J Zhang, K Shi, R Wu, Y Peng
AIM: Using diffusional kurtosis imaging (DKI) to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia A. MATERIALS AND METHODS: Diffusional kurtosis imaging was acquired from haemophilia A (n = 22) and controls (n = 22) using a 3T scanner. A regression analysis of frontal, cingulate, hippocampus, insula and amygdala regions of interest (ROIs) was conducted. Clinical data and results of psychological tests were collected...
February 15, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28203005/-clinical-evaluation-of-periodontal-orthodontic-treatment-in-patients-with-aggressive-periodontitis-and-malocclusion
#7
X Shen, J Shi, L Xu, J Jiao, R F Lu, H X Meng
OBJECTIVE: To evaluate the clinical effect and safety of periodontal-orthodontic treatment in patients with aggressive periodontitis (AgP) and malocclusion. METHODS: A retrospective analysis was conducted in 25 AgP patients, who had received periodontal-orthodontic treatment in Peking University School and Hospital of Stomatology. Clinical indexes, including probing depth (PD), bleeding index (BI) and percentage of sites with bleeding on probing (BOP%) were evaluated at three time points: Baseline (T0); active periodontal treatment finished and before orthodontic treatment (T1); and after orthodontic treatment (T2)...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28202053/up-regulation-of-mir-146a-increases-the-sensitivity-of-non-small-cell-lung-cancer-to-ddp-by-downregulating-cyclin-j
#8
Lin Shi, Zhaozhong Xu, Gang Wu, Xiaoting Chen, Yuanyuan Huang, Yanjing Wang, Weiqiang Jiang, Bin Ke
BACKGROUND: Cisplatin (DDP)-based chemotherapy is the common first-line therapy for lung cancer. However, their efficacy is often limited by primary drug resistance and/or acquired drug resistance. The aim of this study was to investigate the function of miRNA-146a (miR-146a) in DDP-resistant non-small cell lung cancer (NSCLC), as well as the underlying mechanisms. METHODS: The effect of overexpression of miR-146a and/or knockdown of cyclin J (CCNJ) in A549/DDP and SPC-A1/DDP cells were investigated as follows...
February 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28192652/reversible-li-ion-conversion-reaction-for-a-tixge-alloy-in-a-ti-ge-multilayer
#9
Xiao Chen, Tim T Fister, Jennifer Esbenshade, Bing Shi, Xianyi Hu, Jinsong Wu, Andrew A Gewirth, Michael J Bedzyk, Paul Fenter
Group IV intermetallics electrochemically alloy with Li with stoichiometries as high as Li4.4M (M = Si, Ge, Sn, or Pb). This provides the second highest known specific capacity (after pure lithium metal) for lithium-ion batteries, but the dramatic volume change during cycling greatly limits their use as anodes in Li-ion batteries. We describe an approach to overcome this limitation by constructing electrodes using a Ge/Ti multilayer architecture. In operando X-ray reflectivity and ex situ transmission electron microscopy are used to characterize the heterolayer structure at various lithium stoichiometries along a lithiation/delithiation cycle...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28192397/downregulation-of-mir-218-contributes-to-epithelial-mesenchymal-transition-and-tumor-metastasis-in-lung-cancer-by-targeting-slug-zeb2-signaling
#10
Z-M Shi, L Wang, H Shen, C-F Jiang, X Ge, D-M Li, Y-Y Wen, H-R Sun, M-H Pan, W Li, Y-Q Shu, L-Z Liu, S C Peiper, J He, B-H Jiang
Epithelial-mesenchymal transition (EMT) has been recognized as a key element of cell migration and invasion in lung cancer; however, the underlying mechanisms are not fully elucidated. Recently, emerging evidence suggest that miRNAs have crucial roles in control of EMT and EMT-associated traits such as migration, invasion and chemoresistance. Here, we found that miR-218 expression levels were significantly downregulated in lung cancer tissues compared with adjacent non-cancerous tissues, and the levels of miR-218 were significantly associated with histological grades and lymph node metastasis...
February 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28191854/nanostructured-conductive-polymer-gels-as-a-general-framework-material-to-improve-electrochemical-performance-of-cathode-materials-in-li-ion-batteries
#11
Ye Shi, Xingyi Zhou, Jun Zhang, Andrea M Bruck, Andrew C Bond, Amy C Marschilok, Kenneth J Takeuchi, Esther S Takeuchi, Guihua Yu
Controlling architecture of electrode composites is of particular importance to optimize both electronic and ionic conduction within the entire electrode and improve the dispersion of active particles, thus achieving the best energy delivery from a battery. Electrodes based on conventional binder systems that consist of carbon additives and nonconductive binder polymers suffer from aggregation of particles and poor physical connections, leading to decreased effective electronic and ionic conductivities. Here we developed a three-dimensional (3D) nanostructured hybrid inorganic-gel framework electrode by in situ polymerization of conductive polymer gel onto commercial lithium iron phosphate particles...
February 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28186762/synthesis-and-pharmacological-characterization-of-novel-trans-cyclopropylmethyl-linked-bivalent-ligands-that-exhibit-selectivity-and-allosteric-pharmacology-at-the-dopamine-d3-receptor-d3r
#12
Vivek Kumar, Amy E Moritz, Thomas M Keck, Alessandro Bonifazi, Michael P Ellenberger, Christopher D Sibley, R Benjamin Free, Lei Shi, J Robert Lane, David R Sibley, Amy Hauck Newman
The development of bitopic ligands directed toward D2-like receptors has proven to be of particular interest to improve the selectivity and/or affinity of these ligands and as an approach to modulate and bias their efficacies. The structural similarities between dopamine D3 receptor (D3R)-selective molecules that display bitopic or allosteric pharmacology and those that are simply competitive antagonists are subtle and intriguing. Herein we synthesized a series of molecules in which the primary and secondary pharmacophores were derived from the D3R-selective antagonists SB269,652 (1) and SB277011A (2) whose structural similarity and pharmacological disparity provided the perfect templates for SAR investigation...
February 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28186446/de-novo-avm-formation-following-venous-sinus-thrombosis-and-prior-avm-resection-in-adults-report-of-2-cases
#13
Siyu Shi, Raghav Gupta, Justin M Moore, Christoph J Griessenauer, Nimer Adeeb, Rouzbeh Motiei-Langroudi, Ajith J Thomas, Christopher S Ogilvy
Brain arteriovenous malformations (AVMs) are traditionally considered congenital lesions, arising from aberrant vascular development during the intrauterine period. Rarely, however, AVMs develop in the postnatal period. Individual case reports of de novo AVM formation in both pediatric and adult patients have challenged the traditional dogma of a congenital origin. Instead, for these cases, a dynamic picture is emerging of AVM growth and development, initially triggered by ischemic and/or traumatic events, coupled with genetic predispositions...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28185909/customized-biomaterials-to-augment-chondrocyte-gene-therapy
#14
Nizeet I Aguilar, Stephen Trippel, Shuiliang Shi, Lawrence J Bonassar
: A persistent challenge in enhancing gene therapy is the transient availability of the target gene product. This is particularly true in tissue engineering applications. The transient exposure of cells to the product could be insufficient to promote tissue regeneration. Here we report the development of a new material engineered to have a high affinity for a therapeutic gene product. We focus on insulin-like growth factor-I (IGF-I) for its highly anabolic effects on many tissues such as spinal cord, heart, brain and cartilage...
February 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28185657/physical-activity-and-sedentary-behavior-in-breast-and-colon-cancer-survivors-relative-to-adults-without-cancer
#15
Joyce W Shi, Robert J MacInnis, Terry Boyle, Jeff K Vallance, Elisabeth A H Winkler, Brigid M Lynch
OBJECTIVE: To assess differences in accelerometer-assessed moderate- to vigorous-intensity physical activity (MVPA), light-intensity physical activity, and sedentary time between cancer survivors and adults without cancer. PATIENTS AND METHODS: Accelerometer data collected from 241 breast cancer survivors (ACCEL-Breast study, 2013) and 171 colon cancer survivors (ACCEL-Colon study, 2012-2013) were pooled with data collected from adults without cancer (Australian Diabetes, Obesity and Lifestyle accelerometer substudy, 2011-2012)...
February 6, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28182192/dabigatran-potentiates-gemcitabine-induced-growth-inhibition-of-pancreatic-cancer-in-mice
#16
Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke Ten Brink, Dick J Richel, C Arnold Spek
Pancreatic cancer is one of the most lethal solid malignancies with little treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives progression and induces chemoresistance of pancreatic cancer. As thrombin is the prototypical PAR-1 agonist, here we addressed the effect of the direct thrombin inhibitor dabigatran on pancreatic cancer growth and drug resistance in an orthotropic pancreatic cancer model. We show that dabigatran treatment did not affect primary tumor growth whereas it significantly increased tumor dissemination throughout the peritoneal cavity...
February 6, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28179912/a-simple-rapid-method-for-determination-of-melatonin-in-plant-tissues-by-uplc-coupled-with-high-resolution-orbitrap-mass-spectrometry
#17
Tiantian Ye, Yan-Hong Hao, Lei Yu, Haitao Shi, Russel J Reiter, Yu-Qi Feng
Melatonin (MLT) was involved in regulating various stages of plant growth and development. However, due to the low concentration and complex matrixes of plant, the analysis of MLT is a challenging task. In this study, we developed a rapid and efficient method with simplified sample preparation by employing UPLC coupled with a high resolution Orbitrap mass spectrometry, and stable isotope-labeled MLT (MLT-d4) was first used as internal standard in the developed analytical method. In the developed method, we used one-step liquid-liquid extraction to purify the crude extracts both from shoot and root of rice for the analysis, which remarkably simplify the sample preparation process...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28177556/pattern-and-related-factors-of-cognitive-impairment-among-chronic-methamphetamine-users
#18
Tong-Yu Wang, Teng-Teng Fan, Yan-Ping Bao, Xiao-Dong Li, Chun-Mei Liang, Ru-Jia Wang, Jun Ma, Ying Han, Shi-Qiu Meng, Ping Wu, Jie Shi, Lin Lu
BACKGROUND AND OBJECTIVES: Methamphetamine (MA) use is increasingly prevalent in East and Southeast Asia and commonly associated with cognitive impairment. The present study estimated the characteristics of cognitive impairment and explored the associated potential factors among chronic MA users. METHODS: The data were from the baseline visit of a longitudinal study among synthetic drug users. The baseline survey was conducted in detoxification and rehabilitation centers in Guangdong province, China, from September to December in 2013...
February 8, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28177460/pathway-level-alterations-rather-than-mutations-in-single-genes-predict-response-to-her2-targeted-therapies-in-the-neo-altto-trial
#19
W Shi, T Jiang, P Nuciforo, C Hatzis, E Holmes, N Harbeck, C Sotiriou, L Peña, S Loi, D D Rosa, S Chia, A Wardley, T Ueno, J Rossari, H Eidtmann, A Armour, M Piccart-Gebhart, D L Rimm, J Baselga, L Pusztai
No abstract text is available yet for this article.
January 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28174309/understanding-zika-virus-stability-and-developing-a-chimeric-vaccine-through-functional-analysis
#20
Xuping Xie, Yujiao Yang, Antonio E Muruato, Jing Zou, Chao Shan, Bruno T D Nunes, Daniele B A Medeiros, Pedro F C Vasconcelos, Scott C Weaver, Shannan L Rossi, Pei-Yong Shi
: Compared with other flaviviruses, Zika virus (ZIKV) is uniquely associated with congenital diseases in pregnant women. One recent study reported that (i) ZIKV has higher thermostability than dengue virus (DENV [a flavivirus closely related to ZIKV]), which might contribute to the disease outcome; (ii) the higher thermostability of ZIKV could arise from an extended loop structure in domain III of the viral envelope (E) protein and an extra hydrogen-bond interaction between E molecules (V...
February 7, 2017: MBio
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