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https://www.readbyqxmd.com/read/28918118/case-report-aquatic-therapy-and-end-stage-dementia
#1
Bruce E Becker, Stacy Lynch
A 54-year old female, retired due to progressive cognitive decline, was diagnosed with early-onset Alzheimer's dementia. Conventional medication therapy for dementia had proven futile. Initial evaluation revealed a non-verbal female seated in a wheelchair, dependent on 2-person assist for all transfers and activities of daily living (ADLs.) She had been either non-responsive or actively resistive for both ADLs and transfers in the 6 months prior to assessment. Following a total of 17 one hour therapy sessions over 19 weeks in a warm water therapy pool, she achieved ability to tread water for 15 minutes, transfers improved to moderate to-maximum assist from seated, ambulation improved to 1000' with minimum-to-moderate assist of 2 persons...
September 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28917207/exposure-to-ambient-air-pollution-and-the-incidence-of-dementia-a-population-based-cohort-study
#2
Hong Chen, Jeffrey C Kwong, Ray Copes, Perry Hystad, Aaron van Donkelaar, Karen Tu, Jeffrey R Brook, Mark S Goldberg, Randall V Martin, Brian J Murray, Andrew S Wilton, Alexander Kopp, Richard T Burnett
INTRODUCTION: Emerging studies have implicated air pollution in the neurodegenerative processes. Less is known about the influence of air pollution, especially at the relatively low levels, on developing dementia. We conducted a population-based cohort study in Ontario, Canada, where the concentrations of pollutants are among the lowest in the world, to assess whether air pollution exposure is associated with incident dementia. METHODS: The study population comprised all Ontario residents who, on 1 April 2001, were 55-85years old, Canadian-born, and free of physician-diagnosed dementia (~2...
September 13, 2017: Environment International
https://www.readbyqxmd.com/read/28914213/-medical-treatment-of-people-with-dementia-requires-dealing-with-uncertainty
#3
J P J Slaets
Here we report on a number of medical dilemmas during the final 6 years of life of a 78-year-old woman with dementia. Questions concerning both diagnostic procedures and treatment options are discussed. The first dilemma concerns mild symptoms leading to the diagnosis of paroxysmal atrial fibrillation and the requirement for anticoagulation; the second dilemma concerns vague symptoms of tiredness with anaemia leading to the diagnosis of colon cancer and the requirement for surgery. The conclusion is that there are no protocols that can be used to solve questions of this nature, and we need careful reflection with colleagues, the patient and important people in the patient's life in order to make decisions in the best interest of the quality of life as experienced by the patient...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28912995/coprophagia-and-entomophagia-in-a-patient-with-alcohol-related-dementia
#4
João B Fonseca, Pedro Morgado
Coprophagia and entomophagia are two phenomena not commonly reported in the medical literature and their occurrence is usually associated with mental disorders. We present the case of a 59-year-old man with a history of alcohol abuse who was evaluated due to cognitive deterioration and disturbed eating habits including feces and living insects. Organic causes were ruled out and an important cognitive impairment became evident on neuropsychological formal test. The behavior remitted after antipsychotic pharmacologic therapy and alcohol detoxification, leaving the diagnostic impression of alcohol related dementia...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28912076/positive-effects-of-combined-cognitive-and-physical-exercise-training-on-cognitive-function-in-older-adults-with-mild-cognitive-impairment-or-dementia-a-meta-analysis
#5
REVIEW
E G A Esther Karssemeijer, J A Justine Aaronson, W J Willem Bossers, T Tara Smits, M G M Marcel Olde Rikkert, R P C Roy Kessels
Combined cognitive and physical exercise interventions have potential to elicit cognitive benefits in older adults with mild cognitive impairment (MCI) or dementia. This meta-analysis aims to quantify the overall effect of these interventions on global cognitive functioning in older adults with MCI or dementia. Ten randomized controlled trials that applied a combined cognitive-physical intervention with cognitive function as an outcome measure were included. For each study effect sizes were computed (i.e., post-intervention standardized mean difference (SMD) scores) and pooled, using a random-effects meta-analysis...
September 11, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28906030/pathological-and-immunoblot-analysis-of-phosphorylated-tdp-43-in-sporadic-amyotrophic-lateral-sclerosis-with-pallido-nigro-luysian-degeneration
#6
Akiko Uchino, Mieko Ogino, Junko Takahashi-Fujigasaki, Saori Oonuma, Naomi Kanazawa, Sabine Kajita, Masaaki Ichinoe, Masato Hasegawa, Kazutoshi Nishiyama, Shigeo Murayama
Transactivation response DNA-binding protein 43 kDa (TDP-43) is a key protein of sporadic amyotrophic lateral sclerosis (ALS), and phosphorylated form of TDP-43 (p-TDP-43) is a major pathological protein that accumulates in sporadic ALS. p-TDP-43 is found not only in primary motor neurons, but often propagates to non-motor systems as well. However, pallido-nigro-luysian (PNL) degeneration (PNLD) is rarely associated with ALS. We describe here a 68-year-old ALS patient presenting severe PNLD. He had difficulty walking due to poor movement of his right leg, and was diagnosed as having Parkinson's disease because of akinesia...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28902089/new-insights-in-vanishing-white-matter-disease-isolated-bilateral-optic-neuropathy-in-adult-onset-disease
#7
Sandra R Barros, Sónia C R Parreira, Ana F B Miranda, Ana M B Pereira, Nuno M P Campos
BACKGROUND: Vanishing white matter disease (VWMD) is a rare disease affecting cerebral white matter. The adult form is even rarer and manifests with motor symptoms, behavioral problems, and dementia. There is no treatment and progression is inevitable. We describe a case with atypical manifestations and an unusual course. METHODS: Description of a 42-year-old man with VWMD complaining of progressive visual loss in the right eye. RESULTS: The patient's visual acuity was 20/60, right eye, and 20/25, left eye, with pale optic nerves bilaterally...
September 7, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28893250/association-between-dietary-patterns-and-cognitive-function-among-70-year-old-japanese-elderly-a-cross-sectional-analysis-of-the-sonic-study
#8
Hitomi Okubo, Hiroki Inagaki, Yasuyuki Gondo, Kei Kamide, Kazunori Ikebe, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Satoshi Sasaki, Takeshi Nakagawa, Mai Kabayama, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda
BACKGROUND: An increasing number of studies in Western countries have shown that healthy dietary patterns may have a protective effect against cognitive decline and dementia. However, information on this relationship among non-Western populations with different cultural settings is extremely limited. We aim to examine the relationship between dietary patterns and cognitive function among older Japanese people. METHODS: This cross-sectional study included 635 community-dwelling people aged 69-71 years who participated in the prospective cohort study titled Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians (SONIC)...
September 11, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28890043/a-migration-case-of-kii-amyotrophic-lateral-sclerosis-parkinsonism-dementia-complex-with-the-shortest-stay-in-the-endemic-area-and-the-longest-incubation-to-develop-the-disease
#9
Keiichiro Tsunoda, Toru Yamashita, Hitoshi Shimada, Emi Nomura, Yoshiaki Takahashi, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Makoto Higuchi, Tetsuya Suhara, Yasumasa Kokubo, Shigeki Kuzuhara, Koji Abe
Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is an endemic disease observed in the Kii peninsula, Guam, and Papua. We report a case of a 76-year old man with ALS/PDC of the Kii peninsula of Japan (Kii ALS/PDC). The patient was born and grew up in the Kii peninsula. He moved out at age three, and developed symptoms 73years later. He showed pyramidal sign, parkinsonian symptoms, and mildly impaired cognitive function. (131)I-metaiodobenzylguanidine myocardial scintigraphy showed decreased cardiac sympathetic nerve function, and dopamine transporter single photon emission computed tomography imaging showed decreased (123)I-N-ω-fluoropropyl-2β-carbomethoxy3β-(4-iodophenyl) nortropane accumulation...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28890029/natural-course-and-predictors-of-severe-disability-and-death-in-thai-patients-with-dementia
#10
Pornpatr A Dharmasaroja, Praween Lolekha, Kongkiat Kulkantrakorn, Thammanard Charernboon, Arvemas Watcharakorn, Pritsana Piyabhan
More than half of patients with dementia lived in countries with low and middle incomes. However, there have been few studies on the natural course of disease in these countries. The purpose of this study was to study the natural course and the predictive factors of advanced stage and death in Thai patients with dementia. Patients with dementia who were treated in neurologic and psychiatric clinic from September 2004 to February 2016, were included. Data about natural course of diseases, behavioral and psychological symptoms in dementia (BPSD) and complications were studied...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28886705/cognitive-function-in-very-old-men-does-not-correlate-to-biomarkers-of-alzheimer-s-disease
#11
V Velickaite, V Giedraitis, K Ström, I Alafuzoff, H Zetterberg, L Lannfelt, L Kilander, E-M Larsson, M Ingelsson
BACKGROUND: The Alzheimer's disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to relate cognitive performance to the degree of brain atrophy, CSF biomarker levels and neuropathology in a cohort of aged men. METHODS: Fifty-eight 86-92-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM) cohort underwent cognitive testing, brain computed tomography and lumbar puncture...
September 8, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28883785/early-postnatal-but-not-late-adult-neurogenesis-is-impaired-in-the-pitx3-mutant-animal-model-of-parkinson-s-disease
#12
Moritz D Brandt, Diana Krüger-Gerlach, Andreas Hermann, Anne K Meyer, Kwang-Soo Kim, Alexander Storch
The generation of new neurons in the adult dentate gyrus has functional implications for hippocampal formation. Reduced hippocampal neurogenesis has been described in various animal models of hippocampal dysfunction such as dementia and depression, which are both common non-motor-symptoms of Parkinson's disease (PD). As dopamine plays an important role in regulating precursor cell proliferation, the loss of dopaminergic neurons in the substantia nigra (SN) in PD may be related to the reduced neurogenesis observed in the neurogenic regions of the adult brain: subventricular zone (SVZ) and dentate gyrus (DG)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28883241/ketoacidosis-due-to-a-low-carbohydrate-diet-in-an-elderly-woman-with-dementia-and-abnormal-eating-behavior
#13
Hitoshi Iwata, Seiichiro Tsuzuki, Mitsunaga Iwata, Teruhiko Terasawa
Strict restriction of carbohydrates can induce symptomatic ketoacidosis. We herein report a 76-year-old demented woman who developed ketoacidosis after 1 month of abnormal eating behavior involving selectively eating hamburger steak (estimated carbohydrate =12.7 g/day). Laboratory tests showed high-anion-gap metabolic acidosis with elevated blood ketone levels. She was successfully treated with intravenous fluids followed by oral intake of a regular diet. She remained relapse-free after correcting her eating habits...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28872036/decision-making-for-gastrostomy-after-70-years-old-a-prospective-study-about-26-patients
#14
Angéline Mey, Amandine Devun, Marc Roussier, Régis Gonthier, Thomas Celarier
Management of undernutrition is based on young adults analysis. However, enteral nutrition is mainly discussed in the elderly. The aim of this study was to analyse factors related to laying gastrostomy, in geriatrics. A prospective, descriptive study, was conducted in the Loire department, from 2014 to 2016, in geriatric and palliative units. All patients over 70 years who had a theorical indication of gastrostomy were included. Decision-making process was analyzed from data affecting the reflection. Patients were followed for three months...
September 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28869661/utilisation-of-formal-and-informal-care-and-services-at-home-among-persons-with-dementia-a-cross-sectional-study
#15
Christina Bökberg, Gerd Ahlström, Staffan Karlsson
BACKGROUND: The progression of dementia disease implies increasing needs for both informal and formal care and services but also risk of institutionalisation. To better adjust care and services in the phase preceding institutionalisation it is important to find out whether utilisation of formal and informal care and services is determined by increased needs and by who meets the needs. AIM: The aim was to compare persons with dementia (65+) with different levels of cognitive impairment, regarding utilisation of formal and informal care and service at home...
September 4, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28864869/charlson-comorbidity-index-inappropriate-medication-use-and-cognitive-impairment-bermuda-triangle
#16
Kamile Silay, Ahmet Yalcin, Sema Akinci, Fatma Gul Gursoy, Didem Sener Dede
BACKGROUND: The aim is to evaluate the association between the Charlson Comorbidity Index (CCI), polypharmacy, inappropriate medication use and cognitive impairment in long-term care facility patients. METHODS: A cross-sectional study including 105 long-term care facility residents was performed. The Charlson Comorbidity Index (CCI) was used. Inappropriate drug use (IDU) was defined according to the STOPP (Screening Tool of Older People's Prescriptions) criteria...
September 1, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28863046/cognitive-aging-in-black-and-white-americans-cognition-cognitive-decline-and-incidence-of-alzheimer-disease-dementia
#17
Jennifer Weuve, Lisa L Barnes, Carlos F Mendes de Leon, Kumar B Rajan, Todd Beck, Neelum T Aggarwal, Liesi E Hebert, David A Bennett, Robert S Wilson, Denis A Evans
BACKGROUND: US-based studies have reported that older blacks perform worse than older whites on cognitive tests and have higher risk of Alzheimer disease dementia (AD). It is unclear whether these findings reflect differences in cognitive decline. METHODS: The Chicago Health and Aging Project followed individuals, 65+ years old (64% black, 36% white), for up to 18 years. Participants underwent triennial cognitive assessments; stratified randomized samples underwent assessments for AD...
August 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28855495/adult-onset-leukoencephalopathy-with-axonal-spheroids-and-pigmented-glia-a-case-presented-brain-calcification-and-corpus-callosum-atrophy-from-over-10-years-before-the-onset-of-dementia
#18
Miyuki Okamoto, Jun Takeshita, Kazunori Takahashi, Akio Tanaka, Kunihiro Yoshida, Masaru Kuriyama
A 44-year-old man made many mistakes at work over a year. Eleven years prior, he had had medical examination with headache. He presented with symptoms consistent with frontal lobe dysfunction including cognitive decline, and bilateral pyramidal signs. Brain MRI showed cerebral atrophy, localized atrophy of corpus callosum, asymmetrical white matter lesions and multiple cystic lesions. CT images showed bilateral calcifications in the parietal subcortical white matter. Reconstructed sagittal CT images showed bilateral calcifications in the frontal white matter adjacent to the anterior horns of the lateral ventricles, which had a symmetrical "stepping stone appearance" in the frontal pericallosal regions...
August 31, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28846867/simultaneous-measurement-of-whole-blood-vitamin-b1-and-vitamin-b6-using-lc-esi-ms-ms
#19
R J A C Roelofsen-de Beer, B D van Zelst, R Wardle, P G Kooij, Y B de Rijke
Vitamin B1 and B6 have recently been included in the Dutch clinical guidelines for the general practitioner in the differential diagnosis of dementia. To keep up with the sharp rise in the number of requests, an LC-MS/MS method using stable isotopes as internal standards was developed. The active vitamers thiamine pyrophosphate (TPP) and pyridoxal-5'-phosphate (PLP) in whole blood are simultaneously measured with a short run time of 2min. Whole blood is mixed with internal standard solution containing both TPP-d3 and PLP-d3, followed by deproteinization with a trichloroacetic acid (TCA) solution...
August 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28833581/community-mental-health-teams-for-older-people-in-england-variations-in-ways-of-working
#20
Hilde Verbeek, Angela Worden, Mark Wilberforce, Christian Brand, Sue Tucker, Michele Abendstern, David Challis
OBJECTIVE: Integrated community mental health teams (CMHTs) are a key component of specialist old age psychiatry services internationally. However, in England, significant shifts in policy, including a focus on dementia and age inclusive services, have influenced provision. This study portrays teams in 2009 against which subsequent service provision may be compared. METHODS: A bespoke national postal survey of CMHT managers collected data on teams' structure, composition, organisation, working practices, case management, and liaison activities...
August 23, 2017: International Journal of Geriatric Psychiatry
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