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https://www.readbyqxmd.com/read/29145677/-88-year-old-patient-with-known-dementia-and-progressive-vigilance%C3%A2-reduction
#1
Vera Lachmann, Michael Buhr, Amir M Nia
No abstract text is available yet for this article.
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29140857/that-s-inappropriate-social-norms-in-an-older-population-based-cohort
#2
Mary Ganguli, Zhaowen Sun, Eric McDade, Beth Snitz, Tiffany Hughes, Erin Jacobsen, Chung-Chou H Chang
BACKGROUND: Social cognition is not routinely assessed in older adults. We report population-based normative data on the Social Norms Questionnaire (SNQ22) which asks individuals about the appropriateness of specific behaviors in hypothetical scenarios, errors being related either to breaking with norms or to over-adhering to perceived norms. Total SNQ scores represent the number of correct responses while subscale scores are error totals. METHODS: We administered the SNQ22 to 744 adults aged 65+ within a population-based study, and examined the distribution of scores by demographics, other cognitive measures, and Clinical Dementia Rating (CDR)...
November 14, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29133497/comparative-associations-between-measures-of-anti-cholinergic-burden-and-adverse-clinical-outcomes
#3
Wen-Han Hsu, Yu-Wen Wen, Liang-Kung Chen, Fei-Yuan Hsiao
PURPOSE: No consensus has been reached regarding which anticholinergic scoring system works most effectively in clinical settings. The aim of this population-based cohort study was to examine the association between anticholinergic medication burden, as defined by different scales, and adverse clinical outcomes among older adults. METHODS: From Taiwan's Longitudinal Health Insurance Database, we retrieved data on monthly anticholinergic drug use measured by the Anticholinergic Risk Scale (ARS), the Anticholinergic Cognitive Burden Scale (ACB), and the Drug Burden Index - Anticholinergic component (DBI-Ach) for 116,043 people aged 65 years and older during a 10-year follow-up...
November 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#4
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29118481/role-of-cytology-in-early-diagnosis-of-cerebrotendinous-xanthomas
#5
Shreosee Roy, Arghya Bandyopadhyay, Kaushik Bose, Soumi Bhattacharyya
Cerebrotendinous xanthomatosis is a rare autosomal recessive lipid storage disease characterized by widespread tissue deposition of two neutral sterols, cholestenol and cholesterol, resulting in tendinous xanthomas, juvenile cataracts, progressive neurological defects, and premature death from arteriosclerosis. Because it is a treatable cause of cerebellar ataxia and dementia, its early diagnosis is desirable. Here, we have reported the case of an 11-year-old boy with this disorder who was diagnosed based on the cytological findings of fine needle aspiration and clinical features...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29116582/late-onset-first-episode-psychosis-emerging-as-delusional-misidentification-of-familiar-sacred-places-during-a-holy-pilgrimage-a-case-report-and-literature-review
#6
Mahmoud A Awara, Hamdy F Moselhy, Manal O Elnenaei
BACKGROUND: The delusional misidentification syndromes (DMS) include a myriad of discrete but related syndromes, which have wide spectrum anomalies of familiarity. Several misidentification syndromes have been described in the psychiatric literature, the most common of these delusions are: the Capgras syndrome; the Fregoli syndrome; the syndrome of inter-metamorphosis; reduplicative paramnesia; and environmental reduplication. CASE PRESENTATION: The reported case highlights the emergence of late onset first episode psychosis in a Middle Eastern 65-year-old female who has no previous psychiatric history...
November 7, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29115922/the-prevalence-of-dementia-in-a-portuguese-community-sample-a-10-66-dementia-research-group-study
#7
Manuel Gonçalves-Pereira, Ana Cardoso, Ana Verdelho, Joaquim Alves da Silva, Manuel Caldas de Almeida, Alexandra Fernandes, Cátia Raminhos, Cleusa P Ferri, A Matthew Prina, Martin Prince, Miguel Xavier
BACKGROUND: Dementia imposes a high burden of disease worldwide. Recent epidemiological studies in European community samples are scarce. In Portugal, community prevalence data is very limited. The 10/66 Dementia Research Group (DRG) population-based research programmes are focused in low and middle income countries, where the assessments proved to be culture and education fair. We applied the 10/66 DRG prevalence survey methodology in Portugal, where levels of illiteracy in older populations are still high...
November 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29114732/amyloid-%C3%AE-deposition-and-suspected-non-alzheimer-pathophysiology-and-cognitive-decline-patterns-for-12-years-in-oldest-old-participants-without-dementia
#8
Yujing Zhao, Dana L Tudorascu, Oscar L Lopez, Ann D Cohen, Chester A Mathis, Howard J Aizenstein, Julie C Price, Lewis H Kuller, M Ilyas Kamboh, Steven T DeKosky, William E Klunk, Beth E Snitz
Importance: The prevalence of pathologic conditions of the brain associated with Alzheimer disease increases strongly with age. Little is known about the distribution and clinical significance of preclinical biomarker staging in the oldest old, when most individuals without dementia are likely to have positive biomarkers. Objective: To compare the patterns of long-term cognitive decline in multiple domains by preclinical biomarker status in the oldest old without dementia...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29105852/frontotemporal-lobar-degeneration-due-to-p301l-tau-mutation-showing-apathy-and-severe-frontal-atrophy-but-lacking-other-behavioral-changes-a-case-report-and-literature-review
#9
Tomoko Miki, Osamu Yokota, Shintaro Takenoshita, Yoko Mori, Kiyohiro Yamazaki, Yuki Ozaki, Shu-Ichi Ueno, Takashi Haraguchi, Hideki Ishizu, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
The clinical features in cases that have mutations in the microtubule-associated protein tau gene but lack prominent behavioral changes remain unclear. Here, we describe detailed clinical and pathological features of a case carrying the P301L tau mutation that showed only apathy until the middle stage of the course. The mother of this case was suspected to have mild cognitive decline at age 46. However, before she was fully examined, she had a subarachnoid hemorrhage at age 49 and died at age 53. An autopsy was not done...
November 6, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29099906/effects-of-mobility-and-cognition-on-maintenance-of-independence-and-survival-among-women-in-late-life
#10
Susan J Diem, Lui Li-Yung, Lisa Langsetmo, Brent Taylor, Peggy M Cawthon, Jane A Cauley, Kristine E Ensrud
Background: We examined the effects of mobility and cognition on maintenance of independence among women in late life. Methods: Prospective 5-year study of 1,010 independent community-dwelling women (mean age 88.0 years) participating in the Study of Osteoporotic Fractures Year 20 examination (2006-2008). Mobility, ascertained by walk speed, was categorized as good (≥0.9 m/s), intermediate (>0.6 m/s to <0.9 m/s), or poor (≤0.6 m/s). Cognitive status, adjudicated based on neuropsychological tests, was classified as normal or impaired (mild cognitive impairment or dementia)...
November 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29097822/the-benefits-of-multilingualism-to-the-personal-and-professional-development-of-residents-of-the-us
#11
Judith F Kroll, Paola E Dussias
In the past two decades, new research on multilingualism has changed our understanding of the consequences of learning and using two or more languages for cognition, for the brain, and for success and well-being across the entire lifespan. Far from the stereotype that exposure to multiple languages in infancy complicates language and cognitive development, the new findings suggest that individuals benefit from that exposure, with greater openness to other languages and to new learning itself. At the other end of the lifespan, in old age, the active use of two or more languages appears to provide protection against cognitive decline...
2017: Foreign Lang Ann
https://www.readbyqxmd.com/read/29095328/c9orf72-intermediate-repeat-expansion-in-a-patient-with-psychiatric-disorders-and-progressive-cerebellar-ataxia
#12
Mario Meloni, Rita Farris, Paolo Solla, Marcello M Mascia, Francesco Marrosu, Antonino Cannas
INTRODUCTION: Large expansions of the noncoding GGGGCC repeat (more than 30) in the first intron of the C9ORF72 gene have been demonstrated to cause amyotrophic lateral sclerosis and frontotemporal dementia. Recent papers have investigated the possible pathogenic role and associated clinical phenotypes of hexanucleotide expansions with intermediate repeat lengths ranging between 20 and 29 repeats. CASE REPORT: We report a case of a 71-year-old Sardinian female patient with a long history of psychiatric disorders such as mixed anxiety-depressive disorder associated with somatization disorder and histrionic personality who developed a slowly progressive cerebellar syndrome, mild cognitive impairment, pyramidal signs, and rapid eye movement sleep behavior disorder with imaging abnormalities on the DaTSCAN single-photon emission computed tomography indicating an alteration in the presynaptic dopaminergic system...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29094868/hemodynamics-during-dialysis-and-changes-in-cognitive-performance
#13
Dawn Wolfgram, Elisabeth Vogt, Allison L Jahn, Heather M Smith, Joleen Sussman, Alexis Visotcky, Purushottam Laud, Jeff Whittle
INTRODUCTION: Hemodialysis (HD) patients are at increased risk for cognitive impairment. Blood pressure (BP) fluctuations during HD may affect cerebral perfusion and subsequently cognitive function. OBJECTIVE: Examine and provide information on the relationship between intradialytic hemodynamics and cognitive outcomes over a 1-year period. METHODS: HD patients without diagnosed dementia who were 50 years old or older were given a neurocognitive battery at baseline and at 1-year follow-up...
December 2016: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29094499/emergency-medicine-in-the-extreme-geriatric-era-a-retrospective-analysis-of-patients-aged-in-their-mid-90s-and-older-in-the-emergency-department
#14
Martin Müller, Meret E Ricklin, Stefan Weiler, Aristomenis K Exadaktylos, Spyridon Arampatzis
AIM: In the coming years, older individuals will comprise an increasing share of emergency department (ED) admissions, due to the unprecedented and continuing demographic changes. The primary aim of the present study was to identify causes and risk factors for ED admission and hospitalizations in the oldest old. METHODS: We analyzed data of consecutive patients aged in their mid 90s and older (aged ≥94 years) admitted to the ED department of the University Hospital of Bern, Bern, Switzerland, between 2000 and 2010...
November 2, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29089886/depression-and-dementia-in-old-old-population-history-of-depression-may-be-associated-with-dementia-onset-the-tome-project
#15
Yi-Chien Liu, Kenichi Meguro, Kei Nakamura, Kyoko Akanuma, Masahiro Nakatsuka, Takashi Seki, Shutaro Nakaaki, Masaru Mimura, Norito Kawakami
Background: In this study, we investigated the relationship among a history of depression, depressive states, and dementia in a community-based old-old cohort. Methods: From 2012 to 2013, we recruited 200 subjects residing in Tome, Japan. Ultimately, 181 subjects were enrolled in our study and completed the whole study protocol. We used the World Mental Health-Composite International Diagnostic Interview 3.0 to evaluate whether subjects had a history of depression or other affective disorders. Simultaneously, 3...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29074839/acute-onset-vascular-dementia-with-bi-thalamic-infarct-in-an-hiv-positive-subject
#16
Léonard Kouamé Kouassi, Mariam Doumbia-Ouattara
BACKGROUND Bi-thalamic infarctions are rare and marked by clinical polymorphism. Their association with HIV has never been reported. CASE REPORT We report a 51-year-old right-handed man with no medical history, who presented an acute onset vascular dementia associated with an antero-retrograde amnesia, a word-finding difficulty, and a dysexecutive syndrome. The CT scan was normal. Brain MRI revealed a paramedian and bi-thalamic infarction, evoking an occlusion of the Percheron artery. The electrocardiogram, transthoracic and transesophageal cardiac ultrasound, and Doppler echo of cervical arteries gave normal results...
October 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29072103/posterior-cortical-atrophy-of-a-suspected-non-alzheimer-type-a-case-report
#17
Mark T Wagner, Dana M Szeles, Blakely Mulder, Mimi Sohn, Aljoeson Walker
OBJECTIVE: A case of Posterior Cortical Atrophy syndrome of a suspected non-Alzheimer disease pathology type is presented to illustrate prospective diagnosis and course. METHOD: A 54-year-old woman with vague memory complaints underwent serial neuropsychological assessment, MRI, PET, and CSF screening; data are reviewed. RESULTS: While early diagnosis was confounded by multiple factors, classic visuospatial symptoms were later demonstrated using routine neuropsychological methods...
October 26, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/29071699/-cognitive-impairment-as-a-predictor-of-functional-decline-after-hospitalization-decofirh-study
#18
A de Alboniga-Chindurza, C Anciones, F Acebron, D Ibanez, P Roiz-Rey, P Perez-Torre, G Garcia-Ribas
AIM: Cognitive impairment is underdiagnosed in the elderly. We aimed to study the rate of positive responses to an informant-based questionnaires and functional disability after hospital discharge. PATIENTS AND METHODS: Observational prospective case series of patients aged 70-85 years-old admitted for hospitalization in an Internal Medicine ward. All medical records were reviewed and those patients with no previous diagnosis of dementia or related neurological conditions, no previous recent hospitalization or not having a caregiver were evaluated after signing an informed consent...
November 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29064737/effects-of-apoe-haplotypes-and-measures-of-cardiovascular-risk-over-gender-dependent-cognitive-and-functional-changes-in-one-year-in-alzheimer-s-disease
#19
Fabricio Ferreira de Oliveira, Fernando Vieira Pereira, Glaucia Akiko Kamikado Pivi, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci
BACKGROUND: Illiteracy, high cerebrovascular risk and copies of APOE-ϵ4 are risk factors for Alzheimer's disease dementia (AD). We aimed to investigate the impacts of gender, education, coronary heart disease (CHD) risk and creatinine clearance variations, body mass index (BMI) and APOE haplotypes over the rates of cognitive and functional decline of AD in one year. METHODS: Consecutive outpatients with late-onset AD were assessed for gender, schooling, BMI and APOE haplotypes, variations in one year of creatinine clearance and Framingham projections of the 10-year absolute CHD risk, and prospective scores of the Mini-Mental State Examination (MMSE), the Clinical Dementia Rating Sum-of-Boxes (CDR-SOB), the Index of Independence in Activities of Daily Living (ADL) and Lawton's Scale for Instrumental Activities of Daily Living (IADL)...
October 24, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29055464/autosomal-dominant-leukodystrophy-presenting-as-alzheimer-s-type-dementia
#20
Valeria Sandoval-Rodríguez, Mariana Aurora Cansino-Torres, Michel Sáenz-Farret, Gema Castañeda-Cisneros, Gabriel Moreno, Carlos Zúñiga-Ramírez
Autosomal dominant leukodystrophy is a neurodegenerative disorder caused by either point mutations or duplication of the lamin B1 gene on chromosome 5q23. The typical clinical picture consists of autonomic symptoms as well as cerebellar and pyramidal signs. Here we present the case of a 57-year-old female referred to our clinic due to cognitive decline. Neurological examination was significant for cognitive impairment as well as pyramidal and cerebellar signs. Brain MRI displayed diffuse hyperintense lesions in the subcortical white matter, pontine nuclei, brachium pontis and restiform body...
October 2017: Multiple Sclerosis and related Disorders
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