Jessa E Burling, Zoe Katz, Ziwen Yuan, Catherine Munro, Kayden Mimmack, Grace Ma, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Patrizia Vannini, Dorene M Rentz, Yakeel T Quiroz, Keith A Johnson, Reisa A Sperling, Deborah Blacker, Gad A Marshall, Hyun-Sik Yang, Jennifer R Gatchel
OBJECTIVES: We examined relationships between apathy (self and study-partner-reported) and markers of Alzheimer's disease (AD) in older adults. DESIGN: The study utilized a well-characterized sample of participants from the Harvard Aging Brain Study (HABS), a longitudinal cohort study. Participants were cognitively unimpaired without clinically significant neuropsychiatric symptoms at HABS baseline. The dependent variables, apathy evaluation scale-self (AES-S) and informant (AES-I), were administered cross-sectionally between years 6-9 and compared to the independent variables, amyloid and tau PET neuroimaging, from the same year...
January 28, 2024: American Journal of Geriatric Psychiatry