keyword
https://read.qxmd.com/read/38457007/learning-ratio-performance-on-a-brief-visual-learning-and-memory-test-moderates-cognitive-training-gains-in-double-decision-task-in-healthy-older-adults
#21
JOURNAL ARTICLE
Cheshire Hardcastle, Jessica N Kraft, Hanna K Hausman, Andrew O'Shea, Alejandro Albizu, Nicole D Evangelista, Emanuel M Boutzoukas, Emily J Van Etten, Pradyumna K Bharadwaj, Hyun Song, Samantha G Smith, Eric Porges, Steven T DeKosky, Georg A Hishaw, Samuel S Wu, Michael Marsiske, Ronald Cohen, Gene E Alexander, Adam J Woods
Cognitive training using a visual speed-of-processing task, called the Useful Field of View (UFOV) task, reduced dementia risk and reduced decline in activities of daily living at a 10-year follow-up in older adults. However, there was variability in the achievement of cognitive gains after cognitive training across studies, suggesting moderating factors. Learning trials of visual and verbal learning tasks recruit similar cognitive abilities and have overlapping neural correlates with speed-of-processing/working memory tasks and therefore could serve as potential moderators of cognitive training gains...
March 8, 2024: GeroScience
https://read.qxmd.com/read/38456089/association-of-plasma-high-density-lipoprotein-cholesterol-level-with-risk-of-incident-dementia-a-cohort-study-of-healthy-older-adults
#22
JOURNAL ARTICLE
Sultana Monira Hussain, Catherine Robb, Andrew M Tonkin, Paul Lacaze, Trevor T-J Chong, Lawrence J Beilin, Chenglong Yu, Gerald F Watts, Joanne Ryan, Michael E Ernst, Zhen Zhou, Johannes T Neumann, John J McNeil
BACKGROUND: Recent studies have reported associations between high plasma high-density lipoprotein cholesterol (HDL-C) levels and risk of all-cause mortality, age-related macular degeneration, sepsis and fractures, but associations with dementia risk remain unclear. To determine whether high plasma HDL-C levels are associated with increased incident dementia risk in initially-healthy older people. METHODS: We conducted a post-hoc analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial; a double-blind, randomized, placebo-controlled trial of daily low-dose aspirin in healthy older people...
February 2024: The Lancet Regional Health. Western Pacific
https://read.qxmd.com/read/38454901/midlife-cumulative-deficit-frailty-predicts-alzheimer-s-disease-related-plasma-biomarkers-in-older-adults
#23
JOURNAL ARTICLE
Erik Buchholz, Nathan A Gillespie, Jack F Hunt, Chandra A Reynolds, Robert A Rissman, Angelica Schroeder, Isaac Cortes, Tyler Bell, Michael J Lyons, William S Kremen, Carol E Franz
BACKGROUND: The study explores whether frailty at midlife predicts mortality and levels of biomarkers associated with Alzheimer's disease and related dementias (ADRD) and neurodegeneration by early old age. We also examine the heritability of frailty across this age period. METHODS: Participants were 1,286 community-dwelling men from the Vietnam Era Twin Study of Aging at average ages 56, 62 and 68, all without ADRD at baseline. The cumulative deficit frailty index (FI) comprised 37 items assessing multiple physiological systems...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38454193/bdnf-val66met-moderates-episodic-memory-decline-and-tau-biomarker-increases-in-early-sporadic-alzheimer-s-disease
#24
JOURNAL ARTICLE
Diny Thomson, Emily Rosenich, Paul Maruff, Yen Ying Lim
OBJECTIVE: Allelic variation in the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been shown to moderate rates of cognitive decline in preclinical sporadic Alzheimer's disease (AD; i.e., Aβ + older adults), and pre-symptomatic autosomal dominant Alzheimer's disease (ADAD). In ADAD, Met66 was also associated with greater increases in CSF levels of total-tau (t-tau) and phosphorylated tau (p-tau181). This study sought to determine the extent to which BDNF Val66Met is associated with changes in episodic memory and CSF t-tau and p-tau181 in Aβ + older adults in early-stage sporadic AD...
March 7, 2024: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/38450585/balancing-fracture-risk-versus-risk-of-mortality-before-fracture-among-women-aged-80%C3%A2-years-or-older
#25
JOURNAL ARTICLE
John T Schousboe, Lisa Langsetmo, Howard A Fink, Deborah M Kado, Jane A Cauley, Brent C Taylor, Kristine E Ensrud
BACKGROUND: Most fractures occur in women aged ≥80 years but competing mortality unrelated to fracture may limit the benefit of osteoporosis drug therapy for some women in late life. Our primary aim was to develop separate prediction models for non-spine fracture (NSF) and mortality before fracture to identify subsets of women with varying fracture versus mortality risks. METHODS: Separate prediction models were developed for NSF and mortality before NSF for 4895 women aged ≥80 years enrolled in the Study of Osteoporotic Fractures (SOF) or the Health Aging and Body Composition (HABC) study...
March 7, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38443298/study-partner-report-of-apathy-in-older-adults-is-associated-with-ad-biomarkers-findings-from-the-harvard-aging-brain-study
#26
JOURNAL ARTICLE
Jessa E Burling, Zoe Katz, Ziwen Yuan, Catherine Munro, Kayden Mimmack, Grace Ma, Bernard J Hanseeuw, Kathryn V Papp, Rebecca E Amariglio, Patrizia Vannini, Dorene M Rentz, Yakeel T Quiroz, Keith A Johnson, Reisa A Sperling, Deborah Blacker, Gad A Marshall, Hyun-Sik Yang, Jennifer R Gatchel
OBJECTIVES: We examined relationships between apathy (self and study-partner-reported) and markers of Alzheimer's disease (AD) in older adults. DESIGN: The study utilized a well-characterized sample of participants from the Harvard Aging Brain Study (HABS), a longitudinal cohort study. Participants were cognitively unimpaired without clinically significant neuropsychiatric symptoms at HABS baseline. The dependent variables, apathy evaluation scale-self (AES-S) and informant (AES-I), were administered cross-sectionally between years 6-9 and compared to the independent variables, amyloid and tau PET neuroimaging, from the same year...
January 28, 2024: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38438870/digital-interventions-for-healthy-ageing-and-cognitive-health-in-older-adults-a-systematic-review-of-mixed-method-studies-and-meta-analysis
#27
JOURNAL ARTICLE
Yvette I-Pei Tsai, Jeanie Beh, Charlotte Ganderton, Adrian Pranata
BACKGROUND: Currently, there is no systematic review to investigate the effectiveness of digital interventions for healthy ageing and cognitive health of older adults. This study aimed to conduct a systematic review to evaluate the effectiveness of digital intervention studies for facilitating healthy ageing and cognitive health and further identify the considerations of its application to older adults. METHODS: A systematic review and meta-analysis of literature were conducted across CINAHL, Medline, ProQuest, Cochrane, Scopus, and PubMed databases following the PRISMA guideline...
March 4, 2024: BMC Geriatrics
https://read.qxmd.com/read/38433880/effects-of-12-weeks-of-home-based-exercise-training-on-physical-and-cognitive-function-of-older-adults-randomized-trial-comparing-virtual-versus-minimal-supervision-in-the-context-of-the-covid-19-pandemic-in-brazil
#28
JOURNAL ARTICLE
Diógenes Candido Mendes Maranhão, Juliana Daniele de Araújo Silva, Breno Quintella Farah, Natália Barros Beltrão Pirauá, Rodrigo Cappato de Araújo, Bruno Remígio Cavalcante, André Luiz Torres Pirauá
BACKGROUND: We investigated the effects of a 12-week home-based exercise program delivered with virtual or minimal supervision on the physical and cognitive function of community-dwelling older adults in the context of the COVID-19 pandemic in Brazil. METHODS: The study was registered on the Brazilian Registry of Clinical Trials platform (code: RBR-8qby2wt). Thirty-eight older adults (81% female and 68±7 years old), non-disabled, and without cognitive impairment or dementia, were randomly assigned to a 12-week home-based exercise program: 1) virtual supervision (classes remotely delivered through video conference by trained staff), or 2) minimal supervision (once-weekly contact to touch base through standardized text messages)...
March 2024: Canadian Geriatrics Journal: CGJ
https://read.qxmd.com/read/38425303/robust-reference-group-normative-data-for-neuropsychological-tests-accounting-for-primary-language-use-in-asian-american-older-adults
#29
JOURNAL ARTICLE
Arunima Kapoor, Jean K Ho, Jung Yun Jang, Daniel A Nation
OBJECTIVE: The present study aimed to develop neuropsychological norms for older Asian Americans with English as a primary or secondary language, using data from the National Alzheimer's Coordinating Center (NACC). METHOD: A normative sample of Asian American participants was derived from the NACC database using robust criteria: participants were cognitively unimpaired at baseline (i.e., no MCI or dementia) and remained cognitively unimpaired at 1-year follow-up...
March 1, 2024: Journal of the International Neuropsychological Society: JINS
https://read.qxmd.com/read/38415935/the-listening-guide-illustrating-an-underused-voice-centred-methodology-to-foreground-underrepresented-research-populations
#30
JOURNAL ARTICLE
Brianna E Morgan, Nancy A Hodgson, Lauren M Massimo, Sharon M Ravitch
AIM: To highlight the value of utilizing the Listening Guide methodology for nursing research and provide an exemplar applying this methodology to explore a novel concept in an underrepresented group-inner strength in persons newly diagnosed with mild cognitive impairment along with their care partners. DESIGN: Methodology discussion paper. METHODS: The exemplar study used the Listening Guide methods for data elicitation and analysis. Methods included adaptations for the study population and novice qualitative researchers...
February 28, 2024: Journal of Advanced Nursing
https://read.qxmd.com/read/38415908/the-bio-hermes-study-biomarker-database-developed-to-investigate-blood-based-and-digital-biomarkers-in-community-based-diverse-populations-clinically-screened-for-alzheimer-s-disease
#31
JOURNAL ARTICLE
Richard C Mohs, Douglas Beauregard, John Dwyer, Jennifer Gaudioso, Jason Bork, Tamiko MaGee-Rodgers, Mickeal N Key, Diana R Kerwin, Lynn Hughes, Cyndy B Cordell
INTRODUCTION: Alzheimer's disease (AD) trial participants are often screened for eligibility by brain amyloid positron emission tomography/cerebrospinal fluid (PET/CSF), which is inefficient as many are not amyloid positive. Use of blood-based biomarkers may reduce screen failures. METHODS: We recruited 755 non-Hispanic White, 115 Hispanic, 112 non-Hispanic Black, and 19 other minority participants across groups of cognitively normal (n = 417), mild cognitive impairment (n = 312), or mild AD (n = 272) participants...
February 28, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38409714/association-between-cannabis-use-and-subjective-cognitive-decline-findings-from-the-behavioral-risk-factor-surveillance-system-brfss
#32
JOURNAL ARTICLE
Zhi Chen, Roger Wong
BACKGROUND: Cannabis consumption has rapidly increased in the United States due to more states legalizing non-medical and medical use. There is limited research, however, investigating whether cannabis may be associated with cognitive function, particularly across multiple dimensions of cannabis use. OBJECTIVE: The objective of this study was to examine whether cannabis consumption reason, frequency, and method are associated with subjective cognitive decline (SCD)...
February 23, 2024: Current Alzheimer Research
https://read.qxmd.com/read/38405341/prognostic-and-predictive-factors-in-early-alzheimer-s-disease-a-systematic-review
#33
Maria João Garcia, Regina Leadley, Janine Ross, Sasha Bozeat, Gabrielle Redhead, Oskar Hansson, Takeshi Iwatsubo, Nicolas Villain, Jeffrey Cummings
BACKGROUND: Alzheimer's disease (AD) causes progressive decline of cognition and function. There is a lack of systematic literature reviews on prognostic and predictive factors in its early clinical stages (eAD), i.e., mild cognitive impairment due to AD and mild AD dementia. OBJECTIVE: To identify prognostic factors affecting eAD progression and predictive factors for treatment efficacy and safety of approved and/or under late-stage development disease-modifying treatments...
2024: JAD Reports
https://read.qxmd.com/read/38403532/heterogeneity-of-cognition-in-older-adults-with-remitted-major-depressive-disorder-a-latent-profile-analysis
#34
JOURNAL ARTICLE
Tulip Marawi, Peter Zhukovsky, Heather Brooks, Christopher R Bowie, Meryl A Butters, Corinne E Fischer, Alastair J Flint, Nathan Herrmann, Krista L Lanctôt, Linda Mah, Bruce G Pollock, Tarek K Rajji, Aristotle N Voineskos, Benoit H Mulsant
OBJECTIVES: To identify data-driven cognitive profiles in older adults with remitted major depressive disorder (rMDD) with or without mild cognitive impairment (MCI) and examine how the profiles differ regarding demographic, clinical, and neuroimaging measures. DESIGN: Secondary cross-sectional analysis using latent profile analysis. SETTING: Multisite clinical trial in Toronto, Canada. PARTICIPANTS: One hundred seventy-eight participants who met DSM-5 criteria for rMDD without MCI (rMDD-MCI; n = 60) or with MCI (rMDD + MCI; n = 118)...
February 2, 2024: American Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38401746/covid-19-and-influenza-vaccine-co-administration-among-older-u-s-adults
#35
JOURNAL ARTICLE
Daniel A Harris, Preeti Chachlani, Kaleen N Hayes, Ellen P McCarthy, Katherine J Wen, Yalin Deng, Andrew R Zullo, Djeneba Audrey Djibo, Cheryl N McMahill-Walraven, Renae L Smith-Ray, Stefan Gravenstein, Vincent Mor
INTRODUCTION: Co-administering COVID-19 and influenza vaccines is recommended by public health authorities and intended to improve uptake and convenience; however, the extent of vaccine co-administration is largely unknown. Investigations into COVID-19 and influenza vaccine co-administration are needed to describe compliance with newer recommendations and to identify potential gaps in the implementation of co-administration. METHODS: A descriptive, repeated cross-sectional study between September 1, 2021 to November 30, 2021 (Period 1) and September 1, 2022 to November 30, 2022 (Period 2) was conducted...
February 22, 2024: American Journal of Preventive Medicine
https://read.qxmd.com/read/38393905/polypharmacy-and-associated-health-outcomes-in-the-pari-hd-study
#36
JOURNAL ARTICLE
Ivonne Torres-Atencio, Maria B Carreira, Alondra Méndez, Maryonelly Quintero, Adriana Broce, Diana C Oviedo, Giselle Rangel, Alcibiades E Villarreal, Adam E Tratner, Sofía Rodríguez-Araña, Gabrielle B Britton
BACKGROUND: A growing body of evidence points to potential risks associated with polypharmacy (using ≥5 medications) in older adults, but most evidence is derived from studies where racial and ethnic minorities remain underrepresented among research participants. OBJECTIVE: Investigate the association between polypharmacy and cognitive function, subjective health state, frailty, and falls in Hispanic older adults. METHODS: Panama Aging Research Initiative-Health Disparities (PARI-HD) is a community-based cohort study of older adults free of dementia at baseline...
February 17, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38389543/a-scoping-review-on-the-opportunities-for-social-engagement-and-cognitive-frailty-in-older-adults
#37
REVIEW
Sally Fowler Davis, Charlotte Benkowitz, Carol Holland, Alan Gow, Charlotte Clarke
Cognitive frailty (CF) is defined as the clinical syndrome of the combination of physical frailty and cognitive impairment, without dementia. Numerous risk factors for CF have been previously identified but this scoping review focusses on the critical need for social engagement and the association with cognition. The focus of this scoping review on the opportunity for social engagement rather than on perception or experience of loneliness. Based on the results of 55 studies were synthesised into four social engagement categories, namely participation, household, network, and habitat...
2024: Public Health Reviews
https://read.qxmd.com/read/38388111/variation-in-care-and-outcomes-for-people-after-hip-fracture-with-and-without-cognitive-impairment-results-from-the-australian-and-new-zealand-hip-fracture-registry
#38
JOURNAL ARTICLE
Morag E Taylor, Lara A Harvey, Maria Crotty, Ian A Harris, Catherine Sherrington, Jacqueline C T Close
BACKGROUND: People with dementia have poorer outcomes after hip fracture and this may be due in part to variation in care. We aimed to compare care and outcomes for people with and without cognitive impairment after hip fracture. METHODS: Retrospective cohort study using Australian and New Zealand Hip Fracture Registry data for people ≥50 years of age who underwent hip fracture surgery (n = 49,063). Cognitive impairment or known dementia and cognitively healthy groups were defined using preadmission cognitive status...
February 2024: Journal of Nutrition, Health & Aging
https://read.qxmd.com/read/38381532/evaluating-a-novel-24-hour-rest-activity-rhythm-marker-of-preclinical-%C3%AE-amyloid-deposition
#39
JOURNAL ARTICLE
Adam P Spira, Fangyu Liu, Vadim Zipunnikov, Murat Bilgel, Jill A Rabinowitz, Yang An, Junrui Di, Jiawei Bai, Sarah K Wanigatunga, Mark N Wu, Brendan P Lucey, Jennifer A Schrack, Amal A Wanigatunga, Paul B Rosenberg, Eleanor M Simonsick, Keenan A Walker, Luigi Ferrucci, Susan M Resnick
STUDY OBJECTIVES: To compare sleep and 24-hour rest/activity rhythms (RARs) between cognitively normal older adults who are β-amyloid-positive (Aβ or Aβ- and replicate a novel time-of-day-specific difference between these groups identified in a previous exploratory study. METHODS: We studied 82 cognitively normal participants from the Baltimore Longitudinal Study of Aging (aged 75.7 ±8.5 years, 55% female, 76% White) with wrist actigraphy data and Aβ vs...
February 21, 2024: Sleep
https://read.qxmd.com/read/38374884/potential-role-of-apoe-%C3%A9-4-allele-as-a-modifier-for-the-association-of-bdnf-val66met-polymorphisms-and-cognitive-impairment-in-community-dwelling-older-adults
#40
JOURNAL ARTICLE
Shaozhen Ji, Jia Kang, Chao Han, Xitong Xu, Meijie Chen, Jie Chen, Jagadish K Chhetri, Jing Pan, Piu Chan
OBJECTIVE: To determine whether the brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate whether this relationship is modified by the Apolipoprotein E ( APOE ) ɛ4 allele. METHODS: The study is a secondary analysis of 703 participants aged ≥60 years randomly enrolled from the Beijing Longitudinal Study of Aging II prospective cohort...
2024: Frontiers in Aging Neuroscience
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