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https://www.readbyqxmd.com/read/29165558/-she-had-a-smile-on-her-face-as-wide-as-the-great-australian-bite-a-qualitative-examination-of-family-perceptions-of-a-therapeutic-robot-and-a-plush-toy
#1
Wendy Moyle, Marguerite Bramble, Cindy J Jones, Jenny E Murfield, Barbara J Bowers
Background and Objectives: Recent years have seen social robotic pets introduced as a means of treating behavioral and psychological symptoms of dementia, and many show promising potential. In this study, we sought to explore family members' perceptions of the Japanese-developed baby harp seal, Paro (version 9), and a look-alike, nonrobotic Plush Toy, when used by their relative with dementia for 15 min, 3 afternoons per week for 10 weeks. Research Design and Method: The study employed a descriptive qualitative approach, which was nested within a larger cluster randomized controlled trial...
November 19, 2017: Gerontologist
https://www.readbyqxmd.com/read/29156222/cerebral-small-vessel-disease-in-middle-age-and-genetic-predisposition-to-late-onset-alzheimer-s-disease
#2
James D Stefaniak, Li Su, Elijah Mak, Nasim Sheikh Bahaei, Katie Wells, Karen Ritchie, Adam Waldman, Craig W Ritchie, John T O'Brien
INTRODUCTION: Cerebral small vessel disease (CSVD) is associated with late-onset Alzheimer's disease (LOAD) and might contribute to the relationship between apolipoprotein E ε4 (APOEε4) and LOAD, in older people. However, it is unclear whether CSVD begins in middle age in individuals genetically predisposed to LOAD. METHODS: We assessed the relationship between radiological markers of CSVD, white matter hyperintensities and microbleeds, and genetic predisposition to LOAD in a cross-sectional analysis of cognitively normal subjects aged 40-59 years recruited from the PREVENT Dementia study...
November 18, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29154688/substance-use-and-cognitive-function-as-drivers-of-condomless-anal-sex-among-hiv-positive-gay-bisexual-and-other-men-who-have-sex-with-men-aged-50-and-older-the-gold-studies
#3
Sandra A Kupprat, Kristen D Krause, Danielle C Ompad, Perry N Halkitis
PURPOSE: Substance use has been linked to the sexual transmission of HIV among gay, bisexual, and other men who have sex with men (MSM) across the lifespan. Among older, HIV-positive, MSM populations, cognitive dysfunction associated with age and HIV disease progression also may play a role in sexual risk-taking. People aged 50 years and older represent a growing proportion of the overall HIV-positive population. This study aimed to explore relationships between substance use and cognitive function, and their impact on condomless anal sex (CAS) among HIV-positive gay, bisexual, and other MSM aged 50 years and older...
November 20, 2017: LGBT Health
https://www.readbyqxmd.com/read/29149198/experiences-of-older-people-with-dementia-participating-in-a-high-intensity-functional-exercise-program-in-nursing-homes-while-it-s-tough-it-s-useful
#4
Nina Lindelöf, Lillemor Lundin-Olsson, Dawn A Skelton, Berit Lundman, Erik Rosendahl
The objective of the study was to describe the views and experiences of participation in a high-intensity functional exercise (HIFE) program among older people with dementia in nursing homes. The study design was a qualitative interview study with 21 participants (15 women), aged 74-96, and with a Mini-Mental State Examination score of 10-23 at study start. The HIFE-program comprises exercises performed in functional weight-bearing positions and including movements used in everyday tasks. The exercise was individually designed, supervised in small groups in the nursing homes and performed during four months...
2017: PloS One
https://www.readbyqxmd.com/read/29145549/generational-differences-in-the-5-year-incidence-of-age-related-macular-degeneration
#5
Karen J Cruickshanks, David M Nondahl, Lauren J Johnson, Dayna S Dalton, Mary E Fisher, Guan-Hua Huang, Barbara E Klein, Ronald Klein, Carla R Schubert
Importance: Whether a reported decline in the risk of developing age-related macular degeneration (AMD) continued for people born during the Baby Boom years (1946-1964) or later is unknown. These data are important to plan for ocular health care needs in the 21st century. Objectives: To determine whether the 5-year risk for AMD declined by generation and to identify factors that contributed to improvement in risk. Design, Setting, and Participants: Data came from the longitudinal cohort Beaver Dam Eye Study (March 1, 1988, through September 15, 1990, and March 1, 1993, through June 15, 1995) and the Beaver Dam Offspring Study (June 8, 2005, through August 4, 2008, and July 12, 2010, through March 21, 2013)...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29103037/circulating-progenitor-cells-correlate-with-memory-posterior-cortical-thickness-and-hippocampal-perfusion
#6
Daniel A Nation, Alick Tan, Shubir Dutt, Elissa C McIntosh, Belinda Yew, Jean K Ho, Anna E Blanken, Jung Yun Jang, Kathleen E Rodgers, Aimée Gaubert
BACKGROUND: Bone marrow-derived progenitor cells survey the vasculature and home to sites of tissue injury where they can promote repair and regeneration. It has been hypothesized that these cells may play a protective role neurodegenerative and vascular cognitive impairment. OBJECTIVE: To evaluate progenitor cell levels in older adults with and without mild cognitive impairment (MCI), and to relate circulating levels to memory, brain volume, white matter lesion volume, and cerebral perfusion...
November 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29099907/12-year-trajectories-of-depressive-symptoms-in-community-dwelling-older-adults-and-the-subsequent-risk-of-death-over-13-years
#7
Saira Saeed Mirza, M Arfan Ikram, Rosanne Freak-Poli, Albert Hofman, Dimitris Rizopoulos, Henning Tiemeier
Background: Populations of depressed persons are typically comprised of individuals with different courses of depression and thus might carry different risks of death. This study aimed to identify different trajectories of depressive symptoms in community-dwelling older adults and study the risk of death across these trajectories. Methods: In the population-based Rotterdam Study, depressive symptoms (Center for Epidemiological Studies-Depression scale) at three examination-rounds (1993-2004) from 3,325 dementia-free participants (mean age 64·6±6·1 years) were used to identify depression trajectories by latent-class trajectory modeling...
November 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29094499/emergency-medicine-in-the-extreme-geriatric-era-a-retrospective-analysis-of-patients-aged-in-their-mid-90s-and-older-in-the-emergency-department
#8
Martin Müller, Meret E Ricklin, Stefan Weiler, Aristomenis K Exadaktylos, Spyridon Arampatzis
AIM: In the coming years, older individuals will comprise an increasing share of emergency department (ED) admissions, due to the unprecedented and continuing demographic changes. The primary aim of the present study was to identify causes and risk factors for ED admission and hospitalizations in the oldest old. METHODS: We analyzed data of consecutive patients aged in their mid 90s and older (aged ≥94 years) admitted to the ED department of the University Hospital of Bern, Bern, Switzerland, between 2000 and 2010...
November 2, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29076447/aging-in-place-our-house-is-a-very-very-very-fine-house
#9
Jeannette Y Wick
As 10,000 American baby boomers turn 65 years of age every day between 2017 and 2030, society needs to help our aging population find ways to handle the restrictions and limitations that come with increasing age: visual impairment, hearing loss, osteoarthritis, dementia, and other conditions common in older adults. Institutional or long-term care for elderly individuals costs an average of $82,000 to $92,000 per person per year and varies by location. Care in an assisted living facility costs $43,500 per person annually...
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29070481/examining-internet-and-ehealth-practices-and-preferences-survey-study-of-australian-older-adults-with-subjective-memory-complaints-mild-cognitive-impairment-or-dementia
#10
Haley M LaMonica, Amelia English, Ian B Hickie, Jerome Ip, Catriona Ireland, Stacey West, Tim Shaw, Loren Mowszowski, Nick Glozier, Shantel Duffy, Alice A Gibson, Sharon L Naismith
BACKGROUND: Interest in electronic health (eHealth) technologies to screen for and treat a variety of medical and mental health problems is growing exponentially. However, no studies to date have investigated the feasibility of using such e-tools for older adults with mild cognitive impairment (MCI) or dementia. OBJECTIVE: The objective of this study was to describe patterns of Internet use, as well as interest in and preferences for eHealth technologies among older adults with varying degrees of cognitive impairment...
October 25, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29066293/the-mental-activity-and-exercise-max-trial-effects-on-physical-function-and-quality-of-life-among-older-adults-with-cognitive-complaints
#11
Laura E Middleton, Maria I Ventura, Wendy Santos-Modesitt, Gina Poelke, Kristine Yaffe, Deborah E Barnes
BACKGROUND: Older adults with cognitive complaints are vulnerable to dementia, physical impairments, and poor quality of life. Exercise and mental activity may improve physical function and health-related quality of life (HRQOL) but combinations have not been investigated systematically. The Mental Activity and eXercise (MAX) trial found that mental activity plus exercise over 12weeks improved cognitive function (primary outcome) in sedentary older adults with cognitive complaints. OBJECTIVE: To investigate the effects of combinations of two mental activity and exercise programs on physical function and HRQOL (secondary outcomes)...
October 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29064742/seasonal-effects-on-the-sleep-wake-cycle-the-rest-activity-rhythm-and-quality-of-life-for-japanese-and-thai-older-people
#12
Yu Kume, Sachiko Makabe, Naruemol Singha-Dong, Patama Vajamun, Hataichanok Apikomonkon, Jiranan Griffiths
BACKGROUND: The sleep-wake cycle and the rest-activity rhythm are known to change with aging, and such changes have been implicated in higher levels of depression as well as an increased incidence of dementia. However, information supporting seasonal changes in the sleep-wake cycle, the rest-activity rhythm and quality of life in older community-dwelling people remains insufficient. The aim of the present study was to prospectively investigate seasonal effects on the sleep-wake cycle, the rest-activity rhythm and quality of life among older people living in areas of Japan or Thailand with different climate classifications...
October 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29049480/interpreting-biomarker-results-in-individual-patients-with-mild-cognitive-impairment-in-the-alzheimer-s-biomarkers-in-daily-practice-abide-project
#13
Ingrid S van Maurik, Marissa D Zwan, Betty M Tijms, Femke H Bouwman, Charlotte E Teunissen, Philip Scheltens, Mike P Wattjes, Frederik Barkhof, Johannes Berkhof, Wiesje M van der Flier
Importance: Biomarkers do not determine conversion to Alzheimer disease (AD) perfectly, and criteria do not specify how to take patient characteristics into account. Consequently, biomarker use may be challenging for clinicians, especially in patients with mild cognitive impairment (MCI). Objective: To construct biomarker-based prognostic models that enable determination of future AD dementia in patients with MCI. Design, Setting, and Participants: This study is part of the Alzheimer's Biomarkers in Daily Practice (ABIDE) project...
October 16, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29037162/feasibility-of-a-multi-modal-exercise-program-on-cognition-in-older-adults-with-type-2-diabetes-a-pilot-randomised-controlled-trial
#14
M L Callisaya, R M Daly, J E Sharman, D Bruce, T M E Davis, T Greenaway, M Nolan, R Beare, M G Schultz, T Phan, L C Blizzard, V K Srikanth
BACKGROUND: Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D. METHODS: A 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29034310/further-education-improves-cognitive-reserve-and-triggers-improvement-in-selective-cognitive-functions-in-older-adults-the-tasmanian-healthy-brain-project
#15
Megan E Thow, Mathew J Summers, Nichole L Saunders, Jeffery J Summers, Karen Ritchie, James C Vickers
INTRODUCTION: The strong link between early-life education and subsequent reduced risk of dementia suggests that education in later life could enhance cognitive function and may reduce age-related cognitive decline and protect against dementia. METHODS: Episodic memory, working memory, executive function, and language processing performances were assessed annually over 4 years in 359 healthy older adults who attended university for a minimum of 12 months (intervention) and were compared against 100 healthy adult controls...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29020530/doctor-should-i-use-computer-games-to-prevent-dementia
#16
Deirdre M O'Shea, Liselotte De Wit, Glenn E Smith
Commercial advertising of computerized "brain games" may result in clinicians being asked whether brain games prevent dementia. To address this question, we conducted a review of computerized cognitive training (CCT) interventions in older adults with Mild Cognitive Impairment (MCI). Studies were identified using a PubMed and PSYCinfo search for review articles. Within 11 review articles we identified 15 unique studies. Nine of these studies used commercially available "brain games" as their primary CCT intervention...
August 23, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29019061/neuropsychological-measures-that-predict-progression-from-mild-cognitive-impairment-to-alzheimer-s-type-dementia-in-older-adults-a-systematic-review-and-meta-analysis
#17
REVIEW
Sylvie Belleville, Céline Fouquet, Carol Hudon, Hervé Tchala Vignon Zomahoun, Jordie Croteau
This study aimed to determine the extent to which cognitive measures can predict progression from mild cognitive impairment (MCI) to Alzheimer's type dementia (AD), assess the predictive accuracy of different cognitive domain categories, and determine whether accuracy varies as a function of age and length of follow-up. We systematically reviewed and meta-analyzed data from longitudinal studies reporting sensitivity and specificity values for neuropsychological tests to identify individuals with MCI who will develop AD...
October 10, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28973551/region-specific-association-of-subjective-cognitive-decline-with-tauopathy-independent-of-global-%C3%AE-amyloid-burden
#18
Rachel F Buckley, Bernard Hanseeuw, Aaron P Schultz, Patrizia Vannini, Sarah L Aghjayan, Michael J Properzi, Jonathan D Jackson, Elizabeth C Mormino, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio
Importance: The ability to explore associations between reports of subjective cognitive decline (SCD) and biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical β-amyloid [Aβ] and tau) provides an important opportunity to understand the basis of SCD and AD risk. Objective: To examine associations between SCD and global Aβ and tau burdens in regions of interest in clinically healthy older adults. Design, Setting, and Participants: This imaging substudy of the Harvard Aging Brain Study included 133 clinically healthy older participants (Clinical Dementia Rating Scale global scores of 0) participating in the Harvard Aging Brain Study who underwent cross-sectional flortaucipir F 18 (previously known as AV 1451, T807) positron emission tomography (FTP-PET) imaging for tau and Pittsburgh compound B carbon 11-labeled PET (PiB-PET) imaging for Aβ...
October 2, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28972239/interventions-to-improve-the-oral-health-of-people-with-dementia-or-cognitive-impairment-a-review-of-the-literature
#19
E Siegel, M Cations, C Wright, V Naganathan, A Deutsch, L Aerts, H Brodaty
OBJECTIVE: Oral diseases and conditions are prevalent among older people with dementia and cognitive impairment. While many interventions have been advocated for use in this population, evidence for their effectiveness is unclear. Our objective was to review systematically the content and effectiveness of interventions and implementation strategies used to improve or maintain the oral health of people with dementia or cognitive impairment. METHODS: Original studies published in English at any time until January 2015 were identified through electronic searches of the Medline, Embase, CINAHL, Scopus and Cochrane databases and hand searches of eligible studies and relevant reviews...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28966919/short-term-practice-effects-and-amyloid-deposition-providing-information-above-and-beyond-baseline-cognition
#20
K Duff, D B Hammers, B C A Dalley, K R Suhrie, T J Atkinson, K M Rasmussen, K P Horn, B E Beardmore, L D Burrell, N L Foster, J M Hoffman
BACKGROUND: Practice effects, which are improvements in cognitive test scores due to repeated exposure to testing materials, may provide information about Alzheimer's disease pathology, which could be useful for clinical trials enrichment. OBJECTIVES: The current study sought to add to the limited literature on short-term practice effects on cognitive tests and their relationship to amyloid deposition on neuroimaging. PARTICIPANTS: Twenty-seven, non-demented older adults (9 cognitively intact, 18 with mild cognitive impairment) received amyloid imaging with 18F-Flutemetamol, and two cognitive testing sessions across one week to determine practice effects...
2017: Journal of Prevention of Alzheimer's Disease
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