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Dementia AND older e

A John, U Patel, J Rusted, M Richards, D Gaysina
Evidence suggests that affective problems, such as depression and anxiety, increase risk for late-life dementia. However, the extent to which affective problems influence cognitive decline, even many years prior to clinical diagnosis of dementia, is not clear. The present study systematically reviews and synthesises the evidence for the association between affective problems and decline in cognitive state (i.e., decline in non-specific cognitive function) in older adults. An electronic search of PubMed, PsycInfo, Cochrane, and ScienceDirect was conducted to identify studies of the association between depression and anxiety separately and decline in cognitive state...
May 24, 2018: Psychological Medicine
Jing Deng, Cheng Cao, Yi Jiang, Bin Peng, Tingting Wang, Ke Yan, Jingxi Lian, Zengzi Wang
BACKGROUND: China is an ageing society, with around 150 million people aged 60 years or older. The prevalence of dementia will increase by more than 100% in the coming 20 years. This study aimed to investigate the prevalence and effects of dementia among the community elderly in Chongqing, China. METHODS: Cluster sampling was adopted. A sample of elderly individuals aged 60 years and older was extracted as research subjects from three counties within Chongqing, China...
May 14, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
A E Ydstebø, S Bergh, G Selbæk, J Šaltytė Benth, K Brønnick, C Vossius
ABSTRACTObjective:To study longitudinal changes in the quality of life (QoL) in persons with and without dementia, and explore the factors associated with baseline QoL and changes of QoL over the follow-up period. DESIGN: Prospective longitudinal study. SETTING: Data were collected from 17 municipalities in Norway in the period from January 2009 to August 2012. A total of 412 persons were included, 254 (61.7 %) persons without dementia and 158 (38.3 %) with dementia at baseline...
May 11, 2018: International Psychogeriatrics
Kala M Mehta, Dolores Gallagher-Thompson, Mathew Varghese, Santosh Loganathan, Upasana Baruah, Katrin Seeher, Diana Zandi, Tarun Dua, Anne Margriet Pot
BACKGROUND: Dementia has a huge physical, psychological, social and economic impact upon caregivers, families and societies at large. There has been a growing impetus to utilize Internet interventions given the potential scalability, and presumed cost-effectiveness and accessibility. In this paper, we describe the design of a randomized controlled trial (RCT) aiming to study the impact of online self-help programs on caregivers of people with dementia in India. The experimental group will receive an interactive training and support program and the comparison group will receive an education-only e-book...
May 8, 2018: Trials
Susan J Diem, Tien N Vo, Lisa Langsetmo, John T Schousboe, Kristine Yaffe, Kristine E Ensrud
Previous studies examining the association of cognitive impairment and dementia with fracture outcomes in older adults have usually used standard approaches that did not take into account the competing risk of mortality. However, ignoring mortality may not provide accurate estimates of risk of fracture because dementia in older adults strongly predicts death, making mortality a competing risk. 1491 women (mean age 87.6 years) participating in the prospective Study of Osteoporotic Fractures (SOF) Year 20 exam were cognitively assessed and followed to ascertain vital status (deaths verified by death certificates) and hip fractures (confirmed by radiographic reports)...
May 7, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Michael Bauer, Deirdre Fetherstonhaugh, Emily Haesler, Elizabeth Beattie, Keith D Hill, Christopher J Poulos
OBJECTIVES: Educational initiatives can improve care delivery and the experience of living in residential aged care for people with dementia. This review aimed to determine the impact of nurse and care staff education on measures of functional ability and quality of life for older people with dementia living in care homes. DESIGN: Systematic review. DATA SOURCES: Search of on-line databases in English between January 2000 and January 2017...
April 23, 2018: Nurse Education Today
Lu Gao, Rowan Calloway, Emily Zhao, Carol Brayne, Fiona E Matthews
Background: death certification data are routinely collected in most developed countries. Coded causes of death are a readily accessible source and have the potential advantage of providing complete follow-up, but with limitations. Objective: to investigate the reliability of using death certificates for surveillance of dementia, the time trend of recording dementia on death certificates and predictive factors of recording of dementia. Subjects: individuals aged 65 and over in six areas across England and Wales were randomly selected for the Medical Research Council Cognitive Function and Ageing Study (CFAS) and CFAS II with mortality follow-up...
April 28, 2018: Age and Ageing
K H Pitkälä, F C Martin, S Maggi, S K Jyväkorpi, T E Strandberg
OBJECTIVES: The aim of this article is to describe the current status of geriatrics and position of geriatricians in 22 countries of three continents, and to portray their attitudes towards and resources allocated to geriatrics. METHODS: An electronic survey was delivered to a convenience sample of 22 geriatricians in leading positions of their countries. RESULTS: The time required in post graduation specialist training to become a geriatrician varied from one year (subspecialty in the USA) to six years (independent specialty in Belgium)...
2018: Journal of Nutrition, Health & Aging
Shelley E Canning, Michael Gaetz, Darren Blakeborough
Individuals living in long-term residential care homes are often viewed through a negative lens. These residents have increasingly complex care needs, and their functional, communication and cognitive challenges can support conceptualizations of difference and disability perpetuating negative stereotypes of age and dementia. However, engaging in meaningful activities and relationships with older adults, including those with dementia, has been shown to promote positive attitudes. Specifically, intergenerational programming that provides opportunities for meaningful engagement between children and older adults has been shown to support positive emotional experiences through socializing and building relationships...
January 1, 2018: Dementia
Tamsin Santos, Janaka Lovell, Kerrie Shiell, Marilyn Johnson, Joseph E Ibrahim
INTRODUCTION: Self-management is integral to effective chronic disease management. Cognitive impairments (CogImp) associated with dementia have not previously been reviewed in diabetes mellitus (DM) self-care. AIM: (i) Whether CogImp associated with dementia impact self-care. (ii) Whether specific CogImp affects key DM self-care processes. METHOD: A systematic literature search with a narrative review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
April 29, 2018: Diabetes/metabolism Research and Reviews
Claudie Hooper, Philipe De Souto Barreto, Christelle Cantet, Matteo Cesari, Pierre Payoux, Anne Sophie Salabert, Bruno Vellas
BACKGROUND: Inflammation promotes amyloidogenesis in animals and markers of inflammation are associated with β-amyloid (Aβ) in humans. Hence, we sought to examine the cross-sectional associations between chronically elevated plasma C reactive protein (CRP) and cortical Aβ in 259 non-demented elderly individuals reporting subjective memory complaints from the Multidomain Alzheimer Preventive Trial (MAPT). METHODS: Cortical-to-cerebellar standard uptake value ratios were obtained using [18 F] florbetapir positron emission tomography (PET)...
April 25, 2018: Experimental Gerontology
Katie E Osborn, Dandan Liu, Lauren R Samuels, Elizabeth E Moore, Francis E Cambronero, Lealani Mae Y Acosta, Susan P Bell, Michelle A Babicz, Elizabeth A Gordon, Kimberly R Pechman, L Taylor Davis, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
White matter hyperintensities (WMHs) are associated with poorer brain health, but their pathophysiological substrates remain elusive. To better understand the mechanistic underpinnings of WMHs among older adults, this study examined in vivo cerebrospinal fluid biomarkers of β-amyloid42 deposition (Aβ42 ), hyperphosphorylated tau pathology, neurodegeneration (total tau), and axonal injury (neurofilament light [NFL]) in relation to log-transformed WMHs volume. Participants free of clinical stroke and dementia were drawn from the Vanderbilt Memory & Aging Project (n = 148, 72 ± 6 years)...
April 3, 2018: Neurobiology of Aging
Rupak Datta, Mark Trentalange, Peter H Van Ness, Joanne M McGloin, Jack M Guralnik, Michael E Miller, Michael P Walkup, Neelesh Nadkarni, Marco Pahor, Thomas M Gill, Vincent Quagliarello, Manisha Juthani-Mehta
Background/Aims: Clinical trials of older adults are increasingly common, but risks of serious adverse events (SAE) may vary. We describe the incidence of SAE in two randomized trials, one community-based and one nursing home-based. Methods: We performed a secondary data analysis from two randomized clinical trials at one academic health center and 21 nursing homes involving 200 sedentary community dwellers aged 70-89 years and 185 female nursing home residents aged 65 years or older...
March 2018: Contemporary Clinical Trials Communications
Oscar L Lopez, James T Becker, YueFang Chang, William E Klunk, Chester Mathis, Julia Price, Howard J Aizenstein, Beth Snitz, Ann D Cohen, Steven T DeKosky, Milos Ikonomovic, M Ilyas Kamboh, Lewis H Kuller
OBJECTIVES: To test the hypothesis that brain structural integrity (i.e., hippocampal [HIP] volume), white matter lesions (WMLs), and β-amyloid deposition are associated with long-term increased risk of incident dementia and mortality in 183 cognitively normal individuals and patients with mild cognitive impairment (MCI) aged 80 years and older. METHODS: All participants had a brain structural MRI scan and PET scan with 11 C-labeled Pittsburgh compound B in 2009 and were reexamined yearly through 2015 (mean follow-up time 5...
April 25, 2018: Neurology
Cherie Strikwerda-Brown, Annu Mothakunnel, John R Hodges, Olivier Piguet, Muireann Irish
Autobiographical memory (ABM) is typically held to comprise episodic and semantic elements, with the vast majority of studies to date focusing on profiles of episodic details in health and disease. In this context, 'non-episodic' elements are often considered to reflect semantic processing or are discounted from analyses entirely. Mounting evidence suggests that rather than reflecting one unitary entity, semantic autobiographical information may contain discrete subcomponents, which vary in their relative degree of semantic or episodic content...
April 24, 2018: Journal of Neuropsychology
Melike Kahya, Sanghee Moon, Kelly E Lyons, Rajesh Pahwa, Abiodun E Akinwuntan, Hannes Devos
Previous studies have shown that pupillary response, a physiological measure of cognitive workload, reflects cognitive demand in healthy younger and older adults. However, the relationship between cognitive workload and cognitive demand in Parkinson's disease (PD) remains unclear. The aim of this pilot study was to examine the pupillary response to cognitive demand in a letter-number sequencing (LNS) task between 16 non-demented individuals with PD (age, median (Q1-Q3): 68 (62-72); 10 males) and 10 control participants (age: 63 (59-67); 2 males), matched for age, education, and Montreal Cognitive Assessment (MOCA) scores...
2018: Frontiers in Aging Neuroscience
Achille E Tchalla, Jean-Pierre Clément, Isabelle Saulnier, Betty Beaumatin, Florent Lachal, Caroline Gayot, Anaïs Bosetti, Iléana Desormais, Anaïck Perrochon, Pierre-Marie Preux, Philippe Couratier, Thierry Dantoine
BACKGROUND/AIMS: Alzheimer disease (AD) is particularly devastating, with no cure, no means of prevention, and no proven way to slow progression. AD is associated with the worsening of cognitive function attributable to a variety of factors of which little is known. Our main objective was to determine factors associated with rapid cognitive decline (RCD) in older AD patients. METHODS: We conducted a 12-month, prospective, multi-centre cohort study. Community-living individuals aged ≥65 years with mild-to-moderate AD were included...
April 23, 2018: Dementia and Geriatric Cognitive Disorders
Camila de Assis Faria, Heloisa Veiga Dias Alves, Eduarda Naidel Barboza E Barbosa, Helenice Charchat-Fichman
Characterizing cognitive decline in older adults with MCI over time is important to identify the cognitive profile of those who convert to dementia. Objective: This study examined the two-year cognitive trajectory of elderly adults diagnosed with MCI, from geriatrics and neurology outpatient clinics of a public hospital in Rio de Janeiro. Methods: 62 older adults with MCI were submitted to a neuropsychological battery and re-evaluated after two years. The Mann-Whitney U test was employed to assess differences between groups with respect to education, functioning, the Geriatric Depression Scale and diagnosis...
January 2018: Dementia & Neuropsychologia
David Alexander Dickie, Maria Del C Valdés Hernández, Stephen D Makin, Julie Staals, Stewart J Wiseman, Mark E Bastin, Joanna M Wardlaw
Background A structural magnetic resonance imaging measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia. Aim We aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the brain health index. Materials and methods We computed brain health index in N = 288 participants using voxel-based Gaussian mixture model cluster analysis of T1, T2, T2*, and FLAIR magnetic resonance imaging...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Raquel C Gardner, Amy L Byers, Deborah E Barnes, Yixia Li, John Boscardin, Kristine Yaffe
OBJECTIVE: Our aim was to assess risk of Parkinson disease (PD) following traumatic brain injury (TBI), including specifically mild TBI (mTBI), among care recipients in the Veterans Health Administration. METHODS: In this retrospective cohort study, we identified all patients with a TBI diagnosis in Veterans Health Administration databases from October 2002 to September 2014 and age-matched 1:1 to a random sample of patients without TBI. All patients were aged 18 years and older without PD or dementia at baseline...
May 15, 2018: Neurology
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