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https://www.readbyqxmd.com/read/28733759/management-of-gait-changes-and-fall-risk-in-mci-and-dementia
#1
REVIEW
Gilles Allali, Joe Verghese
Gait disorders and falls are very prevalent in aging, especially in older adults with cognitive impairment: older adults with dementia are 2-3 times more likely to fall than their non-demented counterparts. The management of gait disorders and falls in older adults with mild cognitive impairment (MCI) or dementia begins by their identification with the use of specific screening tools, such as measuring gait speed, use of dual-task gait tests, or diagnosing motoric cognitive risk syndrome, a newly described pre-dementia syndrome...
September 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28732820/the-impact-of-cognitive-impairment-on-self-management-in-chronic-obstructive-pulmonary-disease-a-systematic-review
#2
REVIEW
Chelsea Baird, Janaka Lovell, Marilyn Johnson, Kerrie Shiell, Joseph E Ibrahim
OBJECTIVE: To determine the characteristics of persons with cognitive impairment being able to self-manage in chronic obstructive pulmonary disease (COPD). METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance this systematic review examined all studies in English from 1st January 2000 to 20 February 2016, describing the relationship between cognition and COPD self-management domains in older community dwelling persons with dementia or cognitive impairment...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28728889/cognitive-and-motor-functioning-in-elderly-glucocerebrosidase-mutation-carriers
#3
Eileen E Moran, Cuiling Wang, Mindy Katz, Laurie Ozelius, Alison Schwartz, Jelena Pavlovic, Roberto A Ortega, Richard B Lipton, Molly E Zimmerman, Rachel Saunders-Pullman
Mutations in the glucocerebrosidase (GBA) gene are a strong genetic risk factor for the development of Parkinson's disease and dementia with Lewy Bodies. However the penetrance of GBA mutations is low for these diseases in heterozygous carriers. The aim of this study was to examine the relationship between mutation status and cognitive and motor functioning in a sample of community-dwelling older adults. Using linear mixed effects models, we examined the effect of heterozygous mutation status on 736 community-dwelling older adults (≥70 years) without dementia or Parkinson's disease assessed over an average of 6 years, 28 of whom had a single GBA mutation (primarily N370S)...
June 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28724467/differential-associations-between-sensory-loss-and-neuropsychiatric-symptoms-in-adults-with-and-without-a-neurocognitive-disorder
#4
Kim M Kiely, Moyra E Mortby, Kaarin J Anstey
BACKGROUND: To investigate the differential associations between sensory loss and neuropsychiatric symptoms among older adults with and without diagnosed neurocognitive disorder. METHODS: The sample comprised 1,393 adults (52.3% men) aged between 72 and 79 years from a community-based cohort study. There were 213 cases of mild and 64 cases of major neurocognitive disorders. The main outcome was number of informant reported symptoms on the Neuropsychiatric Inventory (NPI)...
July 20, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28717814/malnutrition-in-hospitalised-older-adults-a-multicentre-observational-study-of-prevalence-associations-and-outcomes
#5
E O'Shea, S Trawley, E Manning, A Barrett, V Browne, S Timmons
BACKGROUND: Malnutrition is common in older adults and is associated with high costs and adverse outcomes. The prevalence, predictors and outcomes of malnutrition on admission to hospital are not clear for this population. DESIGN: Prospective Cohort Study. SETTING: Six hospital sites (five public, one private). PARTICIPANTS: In total, 606 older adults aged 70+ were included. All elective and acute admissions to any speciality were eligible...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28704157/survival-rate-and-pressure-ulcer-prevalence-in-patients-with-and-without-dementia-a-retrospective-study
#6
E Jaul, J P Rosenzweig, O Meiron
OBJECTIVE: This retrospective study aimed to investigate the prevalence of pressure ulcers (PUs) in older patients with advanced dementia versus older patients without dementia but with other comorbidities, such as diabetes, ischaemic heart disease and chronic renal failure. PUs were thought to be more prevalent and to present a higher risk of mortality in patients with dementia. METHOD: PUs were assessed on admission using the European Pressure Ulcer Advisory Panel (EPUAP) staging system...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28699394/stepping-out-of-the-shadows-of-alzheimer-s-disease-a-phenomenological-hermeneutic-study-of-older-people-with-alzheimer-s-disease-caring-for-a-therapy-dog
#7
Anna Swall, Britt Ebbeskog, Carina Lundh Hagelin, Ingegerd Fagerberg
PURPOSE: Living with Alzheimer's disease (AD) can involve a person being unable to recall and convey information in daily life. There are several ways to provide person-centred care to older people with AD, e.g. by empowering them in a situation. The use of animal-assisted therapy (AAT) with a therapy dog in the care of people with dementia is increasing, with the presence of a therapy dog being described as improving, among other things, the well-being and socialization of the person...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28693437/effects-of-computerized-cognitive-training-on-neuroimaging-outcomes-in-older-adults-a-systematic-review
#8
Lisanne F Ten Brinke, Jennifer C Davis, Cindy K Barha, Teresa Liu-Ambrose
BACKGROUND: Worldwide, the population is aging and the number of individuals diagnosed with dementia is rising rapidly. Currently, there are no effective pharmaceutical cures. Hence, identifying lifestyle approaches that may prevent, delay, or treat cognitive impairment and dementia in older adults is becoming increasingly important. Computerized Cognitive Training (CCT) is a promising strategy to combat cognitive decline. Yet, the underlying mechanisms of the effect of CCT on cognition remain poorly understood...
July 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28692819/physical-activity-modifies-the-influence-of-apolipoprotein-e-%C3%AE%C2%B54-allele-and-type-2-diabetes-on-dementia-and-cognitive-impairment-among-older-mexican-americans
#9
I-Fan Shih, Kimberly Paul, Mary Haan, Yu Yu, Beate Ritz
INTRODUCTION: The etiologies of dementia are complex and influenced by genetic and environmental factors including medical conditions. METHODS: We used Cox regression model to estimate the individual and joint effects of physical activity (PA), apolipoprotein E (APOE) ε4, and diabetes status on risk of dementia and cognitive impairment without dementia (CIND) among 1438 cognitively intact Mexican American elderly who were followed up to 10 years. RESULTS: The risk of developing dementia/CIND was increased more than threefold in APOE ε4 carriers or diabetics with low levels of PA compared with ε4 noncarriers or nondiabetics who engaged in high PA (ε4: hazard ratio [HR] = 3...
July 7, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28685810/predictors-of-independent-aging-and-survival-a-16-year-follow-up-report-in-octogenarian-men
#10
Kristin Franzon, Liisa Byberg, Per Sjögren, Björn Zethelius, Tommy Cederholm, Lena Kilander
OBJECTIVES: To examine the longitudinal associations between aging with preserved functionality, i.e. independent aging and survival, and lifestyle variables, dietary pattern and cardiovascular risk factors. DESIGN: Cohort study. SETTING: Uppsala Longitudinal Study of Adult Men, Sweden. PARTICIPANTS: Swedish men (n = 1,104) at a mean age of 71 (range 69.4-74.1) were investigated, 369 of whom were evaluated for independent aging 16 years later, at a mean age of 87 (range 84...
July 7, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28684457/pericortical-enhancement-on-delayed-postgadolinium-fluid-attenuated-inversion-recovery-images-in-normal-aging-mild-cognitive-impairment-and-alzheimer-disease
#11
W M Freeze, R S Schnerr, W M Palm, J F Jansen, H I Jacobs, E I Hoff, F R Verhey, W H Backes
BACKGROUND AND PURPOSE: Breakdown of BBB integrity occurs in dementia and may lead to neurodegeneration and cognitive decline. We assessed whether extravasation of gadolinium chelate could be visualized on delayed postcontrast FLAIR images in older individuals with and without cognitive impairment. MATERIALS AND METHODS: Seventy-four individuals participated in this study (15 with Alzheimer disease, 33 with mild cognitive impairment, and 26 with normal cognition)...
July 6, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28672022/apoe-%C3%AE%C2%B54-tomm40-523-haplotypes-and-the-risk-of-alzheimer-s-disease-in-older-caucasian-and-african-americans
#12
Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Jingyun Yang, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennett
Patterns of linkage between the ε4 allele of Apolipoprotein E (APOE) and '523 poly-T alleles in the adjacent gene, TOMM40, differ between Caucasian and African Americans. The extent to which this difference affects the risk of Alzheimer's disease (AD) is unclear. We compared the APOE ε4-TOMM40 '523 haplotypes between older Caucasian and African Americans, and examined their relationship with AD dementia. Data came from three community based cohort studies of diverse participants. APOE genotypes were determined by polymorphisms of rs429358 and rs7412...
2017: PloS One
https://www.readbyqxmd.com/read/28671128/evaluation-of-the-reliability-validity-and%C3%A2-predictive-validity-of-the-subscales-of%C3%A2-the-perceived-stress-scale-in-older-adults
#13
Julie M Jiang, Elizabeth K Seng, Molly E Zimmerman, Martin Sliwinski, Mimi Kim, Richard B Lipton
BACKGROUND: The Perceived Stress Scale (PSS) is made up of two subscales but is typically used as a single summary measure. However, research has shown that the two subscales may have differential properties in older adults. OBJECTIVE: To evaluate the internal consistency, test-retest reliability, and the concurrent and predictive validity for development of amnestic mild cognitive impairment (aMCI) of the positively-worded (PSS-PW) and negatively-worded (PSS-NW) subscale scores of the PSS in older adults...
June 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28671120/neurovascular-specifications-in%C3%A2-the%C3%A2-alzheimer-like-brain-of-mice-affected-by-focal-cerebral-ischemia-implications-for-future-therapies
#14
Dominik Michalski, Sarah Hofmann, Roman Pitsch, Jens Grosche, Wolfgang Härtig
Alzheimer's disease (AD), the most frequent type of dementia, is a prototypical neurodegenerative disease, but shares with stroke certain common risk factors. Consequently, how vascular pathology may modulate AD pathogenesis has gained scientific attention. Therefore, aside from typical features of AD (e.g., amyloid-β, tau hyperphosphorylation, and cholinergic dysfunction), changes within the 'neurovascular unit' (NVU) are of particular interest. This study focused on cholinergic, choline acetyltransferase (ChAT)-immunopositive, and tyrosine hydroxylase (TH)-containing neurons in association with the vasculature to explore the neurovascular complex of the AD brain affected by stroke...
June 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28664561/a-prospective-20-year-longitudinal-follow-up-of-dementia-in-persons-with-down-syndrome
#15
M McCarron, P McCallion, E Reilly, P Dunne, R Carroll, N Mulryan
GOAL: To examine dementia characteristics, age at onset and associated co-morbidities in persons with Down syndrome. METHOD: A total of 77 people with Down syndrome aged 35 years and older were followed up from 1996 to 2015. The diagnosis of dementia was established using the modified ICD 10 Criteria and a combination of objective and informant-based tests. Cognitive tests included the Test for Severe Impairment and the Down Syndrome Mental Status Examination; adaptive behaviour was measured using the Daily Living Skills Questionnaire, and data from the Dementia Questionnaire for People with Intellectual Disabilities have been available since 2005...
June 29, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28661543/implementing-nurse-facilitated-person-centered-care-approaches-for-patients-with-delirium-superimposed-on-dementia-in-the-acute-care-setting
#16
Andrea Yevchak, Donna M Fick, Ann M Kolanowski, Jane McDowell, Todd Monroe, Anna LeViere, Lorraine Mion
Little is understood about the use of person-centered care (PCC) for individuals with delirium superimposed on dementia (DSD), especially in the acute care setting. As part of a larger clinical trial, the purpose of the current exploratory study was to describe examples and qualitatively derived themes of nurse-facilitated PCC for hospitalized older adults with dementia and delirium. A total of 750 delirium rounds were analyzed across three diverse acute care sites. Qualitative derived themes of PCC included: (a) Knowing the Patient's Baseline; (b) Knowing the Patient's Interests and Values; (c) Enhancing Sensory Abilities to Communicate; (d) Individualizing Cognitive Stimulation; and (e) Enhancing Behavioral Approaches to Comfort and Sleep...
June 26, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28659419/aggressiveness-of-care-following-intracerebral-hemorrhage-in-women-and-men
#17
Rahul Guha, Amelia Boehme, Stacie L Demel, Janet J Li, Xuemei Cai, Michael L James, Sebastian Koch, Carl D Langefeld, Charles J Moomaw, Jennifer Osborne, Padmini Sekar, Kevin N Sheth, E Woodrich, Bradford B Worrall, Daniel Woo, Seemant Chaturvedi
OBJECTIVE: To compare comorbidities and use of surgery and palliative care between men and women with intracerebral hemorrhage (ICH). METHODS: The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a prospective, multicenter, case-control study of ICH risk factors and outcomes. We compared comorbidities, treatments, and use of do-not-resuscitate (DNR) orders in men vs women. Multivariate analysis was used to assess the likelihood of ICH surgery and palliative care after adjustment for variables that were p < 0...
June 28, 2017: Neurology
https://www.readbyqxmd.com/read/28658973/the-relation-between-physical-activity-and-cognitive-change-in-older-latinos
#18
Shannon Halloway, JoEllen Wilbur, Michael E Schoeny, Lisa L Barnes
Cognitive impairment in older Latinos is of concern due to the rapid growth of this population and their increased risk for dementia due to chronic disease. Evidence, primarily from studies of non-Latino Whites, suggests that physical activity (PA) may reduce cognitive decline. Few longitudinal studies have included older Latinos, objective measures of PA, or neurocognitive tests that assess domains of cognition. The purpose of this longitudinal study was to explore the relationship between changes in PA and cognitive decline in older Latinos over an average of 5 years...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28655133/the-effect-of-traumatic-brain-injury-history-with-loss-of-consciousness-on-rate-of-cognitive-decline-among-older-adults-with-normal-cognition-and-alzheimer-s-disease-dementia
#19
Yorghos Tripodis, Michael L Alosco, Nikolaos Zirogiannis, Brandon E Gavett, Christine Chaisson, Brett Martin, Michael D McClean, Jesse Mez, Neil Kowall, Robert A Stern
Traumatic brain injury (TBI) is thought to be a risk factor for dementia, including dementia due to Alzheimer's disease (AD). However, the influence of TBI history on the neuropsychological course of AD is unknown and, more broadly, the effect of TBI history on age-related cognitive change is poorly understood. We examined the relationship between history of TBI with loss of consciousness (LOC) history and cognitive change in participants with normal cognition and probable AD, stratified by APOEɛ4 allele status...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28652082/medical-care-activities-among-spouses-of-older-adults-with-functional-disability-implications-for-caregiving-difficulties-and-gains
#20
Courtney A Polenick, Amanda N Leggett, Helen C Kales
OBJECTIVES: Spouses of older adults with functional disability often provide help with their partner's medical care. Yet little is known about the implications of these activities for spouses' caregiving experiences. We examined how spouses' medical care activities are linked to both positive and negative aspects of caregiving (difficulties and gains), and whether these associations vary by their age, gender, or education. DESIGN: Retrospective analysis of data from the 2011 National Health and Aging Trends Study and National Study of Caregiving cross-sectional studies...
May 4, 2017: American Journal of Geriatric Psychiatry
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