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https://www.readbyqxmd.com/read/28340390/the-association-of-eating-performance-and-environmental-stimulation-among-older-adults-with-dementia-in-nursing-homes-a-secondary-analysis
#1
Wen Liu, Ying-Ling Jao, Kristine Williams
BACKGROUND: Nursing home residents with dementia experience increased risk for compromised eating performance due to intrapersonal, interpersonal, and environmental factors. Environmental stimulation is physical, social, and/or sensory stimulation present in the environment that can potentially trigger individuals' emotion or motivate physical reactions. Beyond the personal factors, there is a lack of evidence on how environmental stimulation influences individuals' eating performance at mealtimes...
March 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28340247/usability-testing-of-the-iphone-app-to-improve-pain-assessment-for-older-adults-with-cognitive-impairment-prehospital-setting-a-qualitative-study
#2
Rachael E Docking, Matthew Lane, Pat A Schofield
Objectives. : Pain assessment in older adults with cognitive impairment is often challenging, and paramedics are not given sufficient tools/training to assess pain. The development of a mobile app may improve pain assessment and management in this vulnerable population. We conducted usability testing of a newly developed iPhone pain assessment application with potential users, in this case as a tool for clinical paramedic practice to improve pain assessment of older adults with cognitive impairment...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28329340/baseline-characteristics-of-participants-in-the-aspree-aspirin-in-reducing-events-in-the-elderly-study
#3
John J McNeil, Robyn L Woods, Mark R Nelson, Anne M Murray, Christopher M Reid, Brenda Kirpach, Elsdon Storey, Raj C Shah, Rory S Wolfe, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Jessica E Lockery, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Ruth E Trevaks, Suzanne G Orchard, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Richard H Grimm
Background: There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin that will determine whether 5 years of daily 100-mg enteric-coated aspirin extends disability-free and dementia-free life in a healthy elderly population and whether these benefits outweigh the risks. Methods: Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329149/prediction-of-long-term-cognitive-decline-following-postoperative-delirium-in-older-adults
#4
Elizabeth E Devore, Tamara G Fong, Edward R Marcantonio, Eva M Schmitt, Thomas G Travison, Richard N Jones, Sharon K Inouye
Background: Increasing evidence suggests that postoperative delirium may result in long-term cognitive decline among older adults. Risk factors for such cognitive decline are unknown. Methods: We studied 126 older participants without delirium or dementia upon entering the Successful AGing After Elective Surgery (SAGES) study, who developed postoperative delirium and completed repeated cognitive assessments (up to 36 months of follow-up). Pre-surgical factors were assessed preoperatively and divided into nine groupings of related factors ("domains")...
March 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28327083/the-effect-of-an-interactive-cycling-training-on-cognitive-functioning-in-older-adults-with-mild-dementia-study-protocol-for-a-randomized-controlled-trial
#5
E G A Karssemeijer, W J R Bossers, J A Aaronson, R P C Kessels, M G M Olde Rikkert
BACKGROUND: To date there is no cure or an effective disease-modifying drug to treat dementia. Available acetylcholine-esterase inhibiting drugs or memantine only produce small benefits on cognitive and behavioural functioning and their clinical relevance remains controversial. Combined cognitive-aerobic interventions are an appealing alternative or add-on to current pharmacological treatments. The primary aim of this study is to investigate the efficacy of a combined cognitive-aerobic training and a single aerobic training compared to an active control group in older adults with mild dementia...
March 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28326010/impact-of-resveratrol-on-glucose-control-hippocampal-structure-and-connectivity-and-memory-performance-in-patients-with-mild-cognitive-impairment
#6
Theresa Köbe, A Veronica Witte, Ariane Schnelle, Valentina A Tesky, Johannes Pantel, Jan-Philipp Schuchardt, Andreas Hahn, Jens Bohlken, Ulrike Grittner, Agnes Flöel
In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50-80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28324763/interaction-of-apoe-e4-and-poor-glycemic-control-predicts-white-matter-hyperintensity-growth-from-73-to-76
#7
Simon R Cox, Stuart J Ritchie, David Alexander Dickie, Alison Pattie, Natalie A Royle, Janie Corley, Benjamin S Aribisala, Sarah E Harris, Maria Valdés Hernández, Alan J Gow, Susana Muñoz Maniega, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio...
February 27, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28319243/association-of-antioxidant-supplement-use-and-dementia-in-the-prevention-of-alzheimer-s-disease-by-vitamin-e-and-selenium-trial-preadvise
#8
Richard J Kryscio, Erin L Abner, Allison Caban-Holt, Mark Lovell, Phyllis Goodman, Amy K Darke, Monica Yee, John Crowley, Frederick A Schmitt
Importance: Oxidative stress is an established dementia pathway, but it is unknown if the use of antioxidant supplements can prevent dementia. Objective: To determine if antioxidant supplements (vitamin E or selenium) used alone or in combination can prevent dementia in asymptomatic older men. Design, Setting, and Participants: The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADViSE) trial began as a double-blind randomized clinical trial in May 2002, which transformed into a cohort study from September 2009 to May 2015...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28296910/examining-the-construct-and-known-group-validity-of-a-composite-endpoint-for-the-older-persons-and-informal-caregivers-survey-minimum-data-set-topics-mds-a-large-scale-data-sharing-initiative
#9
Cynthia S Hofman, Jennifer E Lutomski, Han Boter, Bianca M Buurman, Anton J M de Craen, Rogier Donders, Marcel G M Olde Rikkert, Peter Makai, René J F Melis
BACKGROUND: Preference-weighted multi-faceted endpoints have the potential to facilitate comparative effectiveness research that incorporates patient preferences. The Older Persons and Informal Caregivers Survey-Composite endpoint (TOPICS-CEP) is potentially a valuable outcome measure for evaluating interventions in geriatric care as it combines multiple outcomes relevant to older persons in a single metric. The objective of this study was to validate TOPICS-CEP across different study settings (general population, primary care and hospital)...
2017: PloS One
https://www.readbyqxmd.com/read/28291786/association-of-lifelong-exposure-to-cognitive-reserve-enhancing-factors-with-dementia-risk-a-community-based-cohort-study
#10
Hui-Xin Wang, Stuart W S MacDonald, Serhiy Dekhtyar, Laura Fratiglioni
BACKGROUND: Variation in the clinical manifestation of dementia has been associated with differences in cognitive reserve, although less is known about the cumulative effects of exposure to cognitive reserve factors over the life course. We examined the association of cognitive reserve-related factors over the lifespan with the risk of dementia in a community-based cohort of older adults. METHODS AND FINDINGS: Information on early-life education, socioeconomic status, work complexity at age 20, midlife occupation attainment, and late-life leisure activities was collected in a cohort of dementia-free community dwellers aged 75+ y residing in the Kungsholmen district of Stockholm, Sweden, in 1987-1989...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28290708/young-onset-dementia-and-the-need-for-specialist-care-a-national-and-international-perspective
#11
J E Carter, J R Oyebode, R T C M Koopmans
OBJECTIVES: Receiving a timely and accurate diagnosis and gaining access to age-appropriate support for younger people living with dementia (YPD) remains a challenge both in the UK and internationally because the focus of most dementia services is primarily upon the needs of older people. The political case to improve services for YPD depends upon the establishment of an understanding of the clinical symptoms, an unequivocal evidence base about need and an accurate evaluation of the size of the population affected...
March 14, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28283594/cued-memory-decline-in-biomarker-defined-preclinical-alzheimer-disease
#12
Kathryn V Papp, Dorene M Rentz, Elizabeth C Mormino, Aaron P Schultz, Rebecca E Amariglio, Yakeel Quiroz, Keith A Johnson, Reisa A Sperling
OBJECTIVE: To determine whether a decline in cued recall is observable in the preclinical stage of Alzheimer disease (AD) in clinically normal older adults with elevated β-amyloid (Aβ) burden on PET imaging. METHODS: Clinically normal older adults underwent baseline neuroimaging (PET to assess Aβ(+/-) status and MRI) and annual neuropsychological testing. Cox proportional hazards models were used to assess the relative risk of cued memory decline (drop of 1, 2, 3, or 4 points on the total score of the Free and Cued Selective Reminding Test) in relation to neuroimaging measures, functional status, age, sex, and education...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28271346/non-pharmacologic-interventions-for-older-adults-with-subjective-cognitive-decline-systematic-review-meta-analysis-and-preliminary-recommendations
#13
REVIEW
Colette M Smart, Justin E Karr, Corson N Areshenkoff, Laura A Rabin, Carol Hudon, Nicola Gates, Jordan I Ali, Eider M Arenaza-Urquijo, Rachel F Buckley, Gael Chetelat, Harald Hampel, Frank Jessen, Natalie L Marchant, Sietske A M Sikkes, Andrea Tales, Wiesje M van der Flier, Linda Wesselman
In subjective cognitive decline (SCD), older adults present with concerns about self-perceived cognitive decline but are found to have clinically normal function. However, a significant proportion of those adults are subsequently found to develop mild cognitive impairment, Alzheimer's dementia or other neurocognitive disorder. In other cases, SCD may be associated with mood, personality, and physical health concerns. Regardless of etiology, adults with SCD may benefit from interventions that could enhance current function or slow incipient cognitive decline...
March 7, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28270574/mild-cognitive-impairment-is-characterized-by-deficient-brainstem-and-cortical-representations-of-speech
#14
Gavin M Bidelman, Jill E Lowther, Sunghee H Tak, Claude Alain
Mild cognitive impairment (MCI) is recognized as a transitional phase in the progression toward more severe forms of dementia and is an early precursor to Alzheimer's disease. Previous neuroimaging studies reveal MCI is associated with aberrant sensory-perceptual processing in cortical brain regions subserving auditory and language function. However, whether the pathophysiology of MCI extends to speech processing prior to conscious awareness (brainstem) is unknown. Using a novel electrophysiological approach, we recorded both brainstem and cortical speech-evoked brain potentials (ERPs) in older, hearing-matched human listeners who did and did not present with subtle cognitive impairment revealed through behavioral neuropsychological testing...
March 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28269777/what-is-the-relationship-of-traumatic-brain-injury-to-dementia
#15
Mario F Mendez
There is a long history linking traumatic brain injury (TBI) with the development of dementia. Despite significant reservations, such as recall bias or concluding causality for TBI, a summary of recent research points to several conclusions on the TBI-dementia relationship. 1) Increasing severity of a single moderate-to-severe TBI increases the risk of subsequent Alzheimer's disease (AD), the most common type of dementia. 2) Repetitive, often subconcussive, mild TBIs increases the risk for chronic traumatic encephalopathy (CTE), a degenerative neuropathology...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28268613/steady-state-visual-evoked-potential-based-brain-computer-interface-for-cognitive-assessment
#16
Nicolai Westergren, Rasmus L Bendtsen, Troels W Kjaer, Carsten E Thomsen, S Puthusserypady, Helge B D Sorensen
Cognitive assessment is of growing importance, with the general population getting older and a rapidly growing incidence of dementia, which is a major public health issue. Treatment of dementia must, to be most effective, start early in the disease process. Thus, early detection of cognitive decline is important. Cognitive decline may be detected using fully-automated computerized assessment. Such systems will provide inexpensive and widely available screenings of cognitive ability. The aim of this pilot study is to develop a real time steady state visual evoked potential (SSVEP) based brain-computer interface (BCI) for neurological cognitive assessment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267802/multimorbidity-and-healthcare-utilization-among-home-care-clients-with-dementia-in-ontario-canada-a-retrospective-analysis-of-a-population-based-cohort
#17
Luke Mondor, Colleen J Maxwell, David B Hogan, Susan E Bronskill, Andrea Gruneir, Natasha E Lane, Walter P Wodchis
BACKGROUND: For community-dwelling older persons with dementia, the presence of multimorbidity can create complex clinical challenges for both individuals and their physicians, and can contribute to poor outcomes. We quantified the associations between level of multimorbidity (chronic disease burden) and risk of hospitalization and risk of emergency department (ED) visit in a home care cohort with dementia and explored the role of continuity of physician care (COC) in modifying these relationships...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28267788/dementia-incidence-trend-over-1992-2014-in-the-netherlands-analysis-of-primary-care-data
#18
Emma F van Bussel, Edo Richard, Derk L Arts, Astrid C J Nooyens, Preciosa M Coloma, Margot W M de Waal, Marjan van den Akker, Marion C J Biermans, Markus M J Nielen, Kees van Boven, Hugo Smeets, Fiona E Matthews, Carol Brayne, Wim B Busschers, Willem A van Gool, Eric P Moll van Charante
BACKGROUND: Recent reports have suggested declining age-specific incidence rates of dementia in high-income countries over time. Improved education and cardiovascular health in early age have been suggested to be bringing about this effect. The aim of this study was to estimate the age-specific dementia incidence trend in primary care records from a large population in the Netherlands. METHODS AND FINDINGS: A dynamic cohort representative of the Dutch population was composed using primary care records from general practice registration networks (GPRNs) across the country...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28263444/delirium-in-the-emergency-department-and-its-extension-into-hospitalization-delineate-study-effect-on-6-month-function-and-cognition
#19
Jin H Han, Eduard E Vasilevskis, Rameela Chandrasekhar, Xulei Liu, John F Schnelle, Robert S Dittus, E Wesley Ely
BACKGROUND: The natural course and clinical significance of delirium in the emergency department (ED) is unclear. OBJECTIVES: We sought to (1) describe the extent to which delirium in the ED persists into hospitalization (ED delirium duration) and (2) determine how ED delirium duration is associated with 6-month functional status and cognition. DESIGN: Prospective cohort study. SETTING: Tertiary care, academic medical center...
March 6, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28262161/e-mental-health-in-ethnic-minority-a-comparison-of-youtube-and-talk-based-educational-workshops-in-dementia
#20
COMPARATIVE STUDY
Xin Zheng, Benjamin K P Woo
BACKGROUND: Innovation in information and communication technology has been transforming health service delivery. METHODS: This study aims to compare YouTube against traditional talk-based workshops in delivering dementia knowledge to the Chinese-American population. RESULTS: Results reveal that E-mental health has enormous potential; however, for the older Chinese-American ethnic population, talk-based workshop is still more desired in delivering dementia education to targeted age groups...
February 2017: Asian Journal of Psychiatry
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