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https://www.readbyqxmd.com/read/28445649/high-serum-stability-of-collagen-hybridizing-peptides-and-their-fluorophore-conjugates
#1
Lucas L Bennink, Daniel J Smith, Catherine A Foss, Martin G Pomper, Yang Li, S Michael Yu
Collagen hybridizing peptides (CHPs) have a great potential for use in targeted drug delivery, diagnostics, and regenerative medicine due to their ability to specifically bind to denatured collagens associated with many pathologic conditions. Since peptides generally suffer from poor enzymatic stability resulting in rapid degradation and elimination in vivo, CHP's serum stability is a critical parameter that may dictate its pharmacokinetic behavior. Here, we report the serum stability of a series of monomeric CHP derivatives and establish how peptide length, amino acid composition, terminal modification, and linker chemistry influence their availability in serum...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28445609/exosomes-derived-from-mesenchymal-non-small-cell-lung-cancer-cells-promote-chemoresistance
#2
Richard J Lobb, Rosa van Amerongen, Adrian Wiegmans, Sunyoung Ham, Jill E Larsen, Andreas Möller
Non-small cell lung cancer (NSCLC) is the most common lung cancer type and the most common cause of mortality in lung cancer patients. NSCLC is often associated with resistance to chemotherapeutics and together with rapid metastatic spread, results in limited, mostly palliative, treatment options and poor patient survival. NSCLC are heterogeneous, and consist of epithelial and mesenchymal NSCLC cells. Mesenchymal NSCLC cells are thought to be responsible for the chemoresistance phenotype, but if and how this phenotype can be transferred to other NSCLC cells is currently not known...
April 26, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28445221/changes-in-personal-relationships-during-residency-and-their-effects-on-resident-wellness-a-qualitative-study
#3
Marcus Law, Michelle Lam, Diana Wu, Paula Veinot, Maria Mylopoulos
PURPOSE: Residency poses challenges for residents' personal relationships. Research suggests residents rely on family and friends for support during their training. The authors explored the impact of residency demands on residents' personal relationships and the effects changes in those relationships could have on their wellness. METHOD: The authors used a constructivist grounded theory approach. In 2012-2014, they conducted semistructured interviews with a purposive and theoretical sample of 16 Canadian residents from various specialties and training levels...
April 25, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28444679/membranes-derived-from-human-umbilical-cord-wharton-s-jelly-stem-cells-as-novel-bioengineered-tissue-like-constructs
#4
B D Jaimes-Parra, I Garzón, V Carriel, D Durand-Herrera, M A Martín-Piedra, J M García, M C Sánchez-Quevedo, M Alaminos, A Campos
Cell-derived matrices were recently described as novel biomaterials generated by human cells allowed to grow and synthetize their own extracellular matrix in culture. In the present work, we generated and evaluated a novel tissue-like substitute (WDM) consisting of a membrane derived from cultured human Wharton's jelly stem cells. WDM were evaluated ex vivo and in vivo by histochemistry and immunohistochemistry for several mesenchymal cell markers and fibrillar and non-fibrillar extracellular matrix components...
April 26, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28444510/starvation-signals-in-yeast-are-integrated-to-coordinate-metabolic-reprogramming-and-stress-response-to-ensure-longevity
#5
REVIEW
Nianshu Zhang, Lu Cao
Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal transduction pathways (mainly TOR and PKA) have been shown to regulate CLS, yet it is poorly understood how the starvation signals transduced via these pathways lead to CLS extension. Using reporters whose expressions are induced by glucose starvation, we have screened the majority of the 'signaling' mutants in the yeast genome and identified many genes that are necessary for stress response...
April 25, 2017: Current Genetics
https://www.readbyqxmd.com/read/28444034/brazilian-healthcare-in-the-context-of-austerity-private-sector-dominant-government-sector-failing
#6
Nilson do Rosário Costa
This paper presents the arguments in favor of government intervention in financing and regulation of health in Brazil. It describes the organizational arrangement of the Brazilian health system, for the purpose of reflection on the austerity agenda proposed for the country. Based on the literature in health economics, it discusses the hypothesis that the health sector in Brazil functions under the dominance of the private sector. The categories employed for analysis are those of the national health spending figures...
April 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28444008/from-guidelines-to-local-realities-evaluation-of-oral-rehydration-therapy-and-zinc-supplementation-in-guatemala
#7
Rachel Hall-Clifford, Roxanne Amerson
Objective: Diarrhea remains a leading cause of morbidity and mortality for children in low- and middle-income countries throughout the Americas. The World Health Organization (WHO) has developed guidelines on incorporating zinc supplementation (ZS) with traditional oral rehydration therapy (ORT) in order to shorten the duration of diarrheal episodes and to reduce poor health outcomes. Guatemala adopted these guidelines in 2011, but they have not yet been fully implemented at the community level...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443896/an-msn-peg-ip-drug-delivery-system-and-il13r%C3%AE-2-as-targeted-therapy-for-glioma
#8
Jinlong Shi, Shiqiang Hou, Jianfei Huang, Shanshan Wang, Wei Huan, Chuanjun Huang, Xiaojiang Liu, Rui Jiang, Wenbo Qian, Jingjing Lu, Xiubing Wang, Wei Shi, Rongqin Huang, Jian Chen
A combination of gene therapy and chemotherapy has recently received interest as a targeted therapy for glioma. A mesoporous silica nanoparticle (MSN)-based vehicle coated with IL13Rα2-targeted peptide (IP) using polyethylene glycol (PEG), MSN-PEG-IP (MPI), was constructed and confirmed as a potential glioma-targeted drug delivery system in vitro. In this work, tissue microarray (TMA) results revealed that IL13Rα2 was over-expressed in human glioma tissues and that high expression of IL13Rα2 in patients was associated with poor survival...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28443654/quantifying-the-self-assembly-behavior-of-anisotropic-nanoparticles-using-liquid-phase-transmission-electron-microscopy
#9
Binbin Luo, John W Smith, Zihao Ou, Qian Chen
For decades, one of the overarching objectives of self-assembly science has been to define the rules necessary to build functional, artificial materials with rich and adaptive phase behavior from the bottom-up. To this end, the computational and experimental efforts of chemists, physicists, materials scientists, and biologists alike have built a body of knowledge that spans both disciplines and length scales. Indeed, today control of self-assembly is extending even to supramolecular and molecular levels, where crystal engineering and design of porous materials are becoming exciting areas of exploration...
April 26, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28443476/knocking-down-glycoprotein-nonmetastatic-melanoma-protein-b-suppresses-the-proliferation-migration-and-invasion-in-bladder-cancer-cells
#10
Yi-Xiang Zhang, Cai-Peng Qin, Xue-Qi Zhang, Qing-Rong Wang, Chu-Biao Zhao, Ye-Qing Yuan, Jiang-Gen Yang
Glycoprotein nonmetastatic melanoma protein B is a type 1 transmembrane protein that has been recently found to play a role in cancer cell proliferation, angiogenesis, and invasion. Due to its potential responsibility in cancer aggressiveness, the main objective of this work was to investigate its expression in bladder cancer and the biological functions in bladder cancer cells. Using immunohistochemistry, western blot, and reverse transcription polymerase chain reaction, we analyzed the expression of glycoprotein nonmetastatic melanoma protein B in bladder cancer tissues and bladder cancer cell lines...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#11
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28442237/long-term-ert-monitoring-of-biogeochemical-changes-of-an-aged-hydrocarbon-contamination
#12
David Caterina, Adrian Flores Orozco, Frédéric Nguyen
Adequate management of contaminated sites requires information with improved spatio-temporal resolution, in particular to assess bio-geochemical processes, such as the transformation and degradation of contaminants, precipitation of minerals or changes in groundwater geochemistry occurring during and after remediation procedures. Electrical Resistivity Tomography (ERT), a geophysical method sensitive to pore-fluid and pore-geometry properties, permits to gain quasi-continuous information about subsurface properties in real-time and has been consequently widely used for the characterization of hydrocarbon-impacted sediments...
April 10, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28441660/the-phenotype-and-outcome-of-infantile-cardiomyopathy-caused-by-a-homozygous-elac2-mutation
#13
Zarghuna M A Shinwari, Abdulrahman Almesned, Ali Alakhfash, Ahmad M Al-Rashdan, Eissa Faqeih, Zainab Al-Humaidi, Ahmed Alomrani, Malak Alghamdi, Dilek Colak, Abdullah Alwadai, Monther Rababh, Majid Al-Fayyadh, Zuhair N Al-Hassnan
OBJECTIVE: Cardiomyopathy (CMP) in children is a clinically and genetically heterogeneous group of disorders. Disease-associated mutations have been identified in more than 50 genes. Recently, mutations in the mitochondrial tRNA processing gene, ELAC2, were reported to be associated with the recessively inherited form of hypertrophic CMP (HCM). This study is aimed at describing the cardiac phenotype and outcome of ELAC2 mutation. METHODS: We performed whole exome sequencing followed by targeted mutation screening to identify the genetic etiology of severe infantile-onset CMP in 64 consanguineous Saudi families...
April 26, 2017: Cardiology
https://www.readbyqxmd.com/read/28440787/phase-behaviour-of-two-dimensional-mnwox-and-fewox-ternary-oxide-layers-on-pd-100
#14
Nassar Doudin, David Kuhness, Matthias Blatnik, Falko Netzer, Svetlozar Surnev
The structure and properties of ternary oxide materials at the nanoscale are poorly explored both on experimental and theoretical levels. With this work we demonstrate the successful on-surface synthesis of two-dimensional (2D) ternary oxide, MnWOx and FeWOx, nanolayers on a Pd(100) surface and on the understanding of their new structure and phase behaviour with the help of state-of-art surface structure and spectroscopy techniques. We find that the 2D MnWOx and FeWOx phases, prepared under identical thermodynamic conditions, exhibit similar structural properties, reflecting the similarity of the bulk MnWO4 and FeWO4 phases with the wolframite structure...
April 25, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28440652/an-experimental-and-theoretical-study-of-the-thermal-decomposition-of-c4h6-isomers
#15
James Philip Andrew Lockhart, C Franklin Goldsmith, John Batista Randazzo, Branko Ruscic, Robert Simon Tranter
The chemistry of small unsaturated hydrocarbons, such as 1,3-butadiene (1,3-C4H6), 1,2-butadiene (1,2-C4H6), 2-butyne (2-C4H6) and 1-butyne (1-C4H6), is of central importance to the modeling of combustion systems. These species are important intermediates in combustion processes, and yet their high-temperature chemistry remains poorly understood, with various dissociation and isomerization pathways proposed in the literature. Here we investigate the thermal decompositions of 1,3-C4H6, 1,2-C4H6, 2-C4H6 and 1-C4H6 inside a diaphragmless shock tube, at post shock total pressures of 26-261 Torr and temperatures ranging from 1428-2354 K, using laser schlieren densitometry...
April 25, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28440288/longitudinal-spin-seebeck-coefficient-heat-flux-vs-temperature-difference-method
#16
A Sola, P Bougiatioti, M Kuepferling, D Meier, G Reiss, M Pasquale, T Kuschel, V Basso
The determination of the longitudinal spin Seebeck effect (LSSE) coefficient is currently plagued by a large uncertainty due to the poor reproducibility of the experimental conditions used in its measurement. In this work we present a detailed analysis of two different methods used for the determination of the LSSE coefficient. We have performed LSSE experiments in different laboratories, by using different setups and employing both the temperature difference method and the heat flux method. We found that the lack of reproducibility can be mainly attributed to the thermal contact resistance between the sample and the thermal baths which generate the temperature gradient...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440197/hyperprolactinemia-induced-by-antipsychotics-from-diagnosis-to-treatment-approach
#17
Walter Milano, Chiara Colletti, Anna Capasso
Schizophrenia is one of the most severe psychiatric diseases with a significant impact on the psychosocial functioning of the patients. People with schizophrenia are at risk to die prematurely because of their illness with their poor lifestyle contributing to the excess morbidity and higher mortality rate. In particular, lifestyle (e.g. poor diet, low rates of physical activity and increased likelihood to smoke cigarettes) predisposes them to poor physical health and comorbid medical diseases. In addition, the treatment of schizophrenia usually involves the long-term administration of antipsychotic drugs and some of these medications are implicated in the increased risk of metabolic and cardiovascular effects...
April 23, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28439462/microanatomy-and-paleohistology-of-the-intercentra-of-north-american-metoposaurids-from-the-upper-triassic-of-petrified-forest-national-park-arizona-usa-with-implications-for-the-taxonomy-and-ontogeny-of-the-group
#18
Bryan M Gee, William G Parker, Adam D Marsh
Metoposaurids are temnospondyl amphibians that are commonly recovered from the Chinle Formation deposits of North America. Two species, Koskinonodon perfectus and Apachesaurus gregorii, are known from Petrified Forest National Park (PEFO), AZ. Small, elongate intercentra are the single diagnostic postcranial characteristic of the smaller A. gregorii. However, a poor understanding of the earliest life stages of Koskinonodon perfectus and other large metoposaurids makes it unclear whether the proportions of the intercentra are a diagnostic feature for species discrimination or whether they are influenced by ontogeny...
2017: PeerJ
https://www.readbyqxmd.com/read/28439383/the-association-between-quality-of-sleep-and-health-related-quality-of-life-in-military-and-non-military-women-in-tehran-iran
#19
Narges Roustaei, Hajar Jamali, Mohammad Reza Jamali, Pegah Nourshargh, Jamshid Jamali
OBJECTIVES: Quality of sleep (QoS) in individuals is affected by their occupation and is one of the factors affecting the quality of life (QoL). Few studies have evaluated the relationship between QoS and QoL in military women personnel. The aim of this study was to assess QoL and QoS, and compare their relationship among military and non-military women in Tehran. METHODS: This cross-sectional study was carried out on 90 women working in Tehran during 2014, 30 were military forces, 30 were military staff, and 30 were civilian organizations staff...
March 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28439362/use-of-a-90-minute-admission-window-and-front-fill-system-to-reduce-work-compression-on-a-general-medicine-inpatient-teaching-service
#20
Youngjee Choi, Daniel Kim, Hyemi Chong, Christopher Mallow, Jason Bill, Anthony T Fojo, Melvin Blanchard
BACKGROUND: Duty hour limits have shortened intern shifts without concurrent reductions in workload, creating work compression. Multiple admissions during shortened shifts can result in poor training experience and patient care. OBJECTIVE: To relieve work compression, improve resident satisfaction, and improve duty hour compliance in an academic internal medicine program. METHODS: In 2014, interns on general ward services were allotted 90 minutes per admission from 3 pm to 7 pm, when the rate of admissions was high...
April 2017: Journal of Graduate Medical Education
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