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https://www.readbyqxmd.com/read/28078990/mass-spectrometry-imaging-in-nanomedicine-unraveling-the-potential-of-msi-for-the-detection-of-nanoparticles-in-neuroscience
#1
Florian Py Barré, Ron Ma Heeren, Nina Ogrinc Potočnik
Mass spectrometry imaging (MSI) can uniquely detect thousands of compounds allowing both their identification and localization within biological tissue samples. MSI is an interdisciplinary science that crosses the borders of physics, chemistry and biology, and enables local molecular analysis at a broad range of length scales: From the subcellular level to whole body tissue sections. The spatial resolution of some mass spectrometers now allows nano-scale research, crucial for studies in nanomedicine. Recent developments in MSI have enabled the optimization and localization of drug delivery with nanoparticles within the body and in specific organs such as kidney, liver and brain...
January 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28071266/biogen-s-portfolio-and-research-efforts-in-multiple-sclerosis-an-interview-with-dr-ralph-kern
#2
Ralph Kern
Ralph Kern speaks to Laura Dormer, Commissioning Editor: Dr Ralph Kern is Senior Vice President and Head of Worldwide Medical at Biogen in Cambridge, MA, USA. In this role, he oversees Biogen's global therapeutic, regional and country medical teams, global medical operations, as well as medical research and scientific communications functions. Prior to joining Biogen, he was head of the Neuroscience Medical Unit at Novartis Pharmaceuticals Corporation and held various medical and commercial leadership roles at Genzyme Corporation...
January 10, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28064175/neuroimaging-of-inflammation-in-memory-and-related-other-disorders-nimrod-study-protocol-a-deep-phenotyping-cohort-study-of-the-role-of-brain-inflammation-in-dementia-depression-and-other-neurological-illnesses
#3
W Richard Bevan-Jones, Ajenthan Surendranathan, Luca Passamonti, Patricia Vázquez Rodríguez, Robert Arnold, Elijah Mak, Li Su, Jonathan P Coles, Tim D Fryer, Young T Hong, Guy Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
INTRODUCTION: Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia and depression, but it is not clear how such inflammation relates to other aspects of neuropathology, structural and functional changes in the brain and symptoms (as assessed via clinical and neuropsychological assessment and MRI). This study will explore these pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis...
January 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28047131/su-g-iep2-14-validation-of-plastimatch-mabs-a-tool-for-automatic-image-segmentation
#4
P Zaffino, P Raudaschl, K Fritscher, M Spadea, G Sharp
PURPOSE: In this work we present the validation of Plastimatch MABS, an open source software for multi atlas based segmentation of medical images. METHODS: The validation was performed on two different clinical datasets: 1) 25 CT image volumes of patients treated for H&N cancer; 2) 20 MRI series of patients having a neurological diagnosis. For the first set, 8 organs at risk to be spared during the therapy were segmented: mandible, brainstem and both left/right optic nerves, parotid and submandibular glands...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032783/neurological-exclusiveness-or-unified-science-inclusiveness-comment-on-schwartz-et-al-2016
#5
Arthur W Staats
Schwartz, Lilienfeld, Meca, and Sauvigné (2016) argue effectively and productively that neuroscience is monistic (excludes other fields) in a way that affects negatively psychology department makeup, psychology grant support, and the way students are trained. They conclude, rather, that it is important to effect an inclusion of different fields of psychology. This paper broadens and strengthens their position. However, it also points out that a call for inclusiveness raises a central question. How is inclusiveness to be accomplished? Without stipulation to the contrary the call is for an eclecticism...
December 2016: American Psychologist
https://www.readbyqxmd.com/read/28032249/anxiety-and-depressive-symptoms-among-two-seriously-medically-ill-populations-and-their-family-caregivers-a-comparison-and-clinical-implications
#6
Kelly M Shaffer, Jamie M Jacobs, Jessica N Coleman, Jennifer S Temel, Jonathan Rosand, Joseph A Greer, Ana-Maria Vranceanu
BACKGROUND: Anxiety and depression are common among patients with acute illness and their families. In oncology, psychosocial services addressing these symptoms are increasingly part of regular practice. Less is known about psychiatric distress among patients with acute neurological injury (ANI) and their family caregivers. To highlight this inequity in psychosocial intervention across medical services, we compared anxiety and depressive symptomatology shortly following diagnosis among patients facing incurable cancer or ANI and their family caregivers...
December 28, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/28031978/translational-research-needs-us-to-go-back-to-basics-and-collaborate-interview-with-lars-sundstrom
#7
Lars Sundstrom
Lars Sundstrom is Director of Enterprise and Translation at the West of England Academic Health Sciences Network [1] (UK), a Professor of Practice in Translational Medicine and Co-Director of the Elizabeth Blackwell Institute for Health Research at Bristol University [2] (UK), and an honorary Professor of Medicine at Cardiff University (UK). He has extensive experience in translational medicine and clinical neurosciences, holding positions at several eminent universities. He has also held executive and board-level positions at several SMEs, developing new therapeutics for neurological conditions and tools for drug discovery...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/28017150/nanotechnology-in-neuroscience-and-its-perspective-as-gene-carrier
#8
T M T Khan, D Wei, P H L Tran, T D T Thao
Gene therapy has a strong potential in neuroscience by suppressing or replacing abnormalities in genetic materials. The employment of nano-gene carrier for neurological disorders is comparatively young and restricted since the aim to effectively deliver therapeutic agents into the central nervous system (CNS) commonly has confronted difficulties of several natural occurring barriers in the body and unfavorable characteristics of pharmaceutical agents. Two major anatomical and biochemical barriers are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), which significantly prevent permeation of most drugs and genes to brain parenchyma...
December 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28012058/glutamate-and-brain-glutaminases-in-drug-addiction
#9
Javier Márquez, José A Campos-Sandoval, Ana Peñalver, José M Matés, Juan A Segura, Eduardo Blanco, Francisco J Alonso, Fernando Rodríguez de Fonseca
Glutamate is the principal excitatory neurotransmitter in the central nervous system and its actions are related to the behavioral effects of psychostimulant drugs. In the last two decades, basic neuroscience research and preclinical studies with animal models are suggesting a critical role for glutamate transmission in drug reward, reinforcement, and relapse. Although most of the interest has been centered in post-synaptic glutamate receptors, the presynaptic synthesis of glutamate through brain glutaminases may also contribute to imbalances in glutamate homeostasis, a key feature of the glutamatergic hypothesis of addiction...
December 23, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/28005425/a-hidden-epithelial-barrier-in-the-brain-with-a-central-role-in-regulating-brain-homeostasis-implications-for-aging
#10
Roosmarijn E Vandenbroucke
Despite increasing interest the last years, the choroid plexus still is a relatively understudied tissue in neuroscience. The choroid plexus contains fenestrated capillaries surrounded by tightly connected choroid plexus epithelial cells that form the blood-cerebrospinal fluid barrier. The choroid plexus is the main source of cerebrospinal fluid production, assures removal of toxic waste products, and acts as gatekeeper of the brain by the presence of resident inflammatory cells. Increasing evidence shows that choroid plexus' dysfunction, via altered secretory, transport, immune, and barrier function, plays a central role in a very diverse set of clinical conditions such as aging and the age-associated Alzheimer's disease...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28005054/-bioethics-in-russian-neurology-and-epileptology
#11
E P Mikhalovska-Karlova
Historical roots and further development of bioethics in domestic neurology and epileptology are considered. The main bioethical principles were established during the formation of the Russian clinical school and neurosciences. It is most distinctly seen in the development of bioethics in neurology and epileptology. In the author's opinion, the Russian scientist V.M. Bekhterev had played a prominent role in the field. In the time when the term "bioethics" was not coined and its principles were not formulated, V...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27999993/the-sugar-code-in-neuronal-physiology
#12
REVIEW
Alonso M Higuero, Natalia Díez-Revuelta, José Abad-Rodríguez
Carbohydrate-related interactions are necessary for the correct development and function of the nervous system. As we illustrate with several examples, those interactions are controlled by carbohydrate-modifying enzymes and by carbohydrate-binding proteins that regulate a plethora of complex axonal processes. Among others, glycan-related proteins as sialidase Neu3 or galectins-1, -3, and -4 play central roles in the determination of axonal fate, axon growth, guidance and regeneration, as well as in polarized axonal glycoprotein transport...
December 20, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27959269/how-lateral-inhibition-and-fast-retinogeniculo-cortical-oscillations-create-vision-a-new-hypothesis
#13
Ravinder Jerath, Shannon M Cearley, Vernon A Barnes, Elizabeth Nixon-Shapiro
: The role of the physiological processes involved in human vision escapes clarification in current literature. Many unanswered questions about vision include: 1) whether there is more to lateral inhibition than previously proposed, 2) the role of the discs in rods and cones, 3) how inverted images on the retina are converted to erect images for visual perception, 4) what portion of the image formed on the retina is actually processed in the brain, 5) the reason we have an after-image with antagonistic colors, and 6) how we remember space...
November 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27942478/arterial-spin-labeling-perfusion-magnetic-resonance-imaging-of-non-human-primates
#14
Xiaodong Zhang, Chun-Xia Li
Non-human primates (NHPs) resemble most aspects of humans in brain physiology and anatomy and are excellent animal models for translational research in neuroscience, biomedical research and pharmaceutical development. Cerebral blood flow (CBF) offers essential physiological information of the brain to examine the abnormal functionality in NHP models with cerebral vascular diseases and neurological disorders or dementia. Arterial spin labeling (ASL) perfusion MRI techniques allow for high temporal and spatial CBF measurement and are intensively used in studies of animals and humans...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27918065/a-statistical-proposal-for-selecting-a-data-depending-threshold-in-neurobiology
#15
P Finotelli, F Panzica, P Dulio, F Rotondi, G Varotto
In this paper we propose a new methodology for introducing thresholds in the analysis of neuro- biological databases. Often, in Neuroscience, absolute thresholds are adopted. This is done by cutting the data below (or above) predetermined values of the involved parameters, without an analysis of the distribution of the collected data concerning the phenomenon under investigation. Despite an absolute threshold could be rigorously defined in terms of physic parameters, it can be influenced by many different subjective aspects, including cognitive processes, and individual adaptation to the external stimuli...
June 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/27913429/heritability-of-the-effective-connectivity-in-the-resting-state-default-mode-network
#16
Junhai Xu, Xuntao Yin, Haitao Ge, Yan Han, Zengchang Pang, Baolin Liu, Shuwei Liu, Karl Friston
The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity...
November 23, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27902445/focus-issue-new-horizons-for-treating-neurological-disease
#17
EDITORIAL
Leslie K Ferrarelli
This issue of Science Signaling highlights research that uncovers protein interaction networks and potential drug targets, as well as research that identifies molecular mechanisms of action of novel or existing drugs, for neurological and psychological disease. This Editorial Guide features a handful of papers from 2016 that join the ranks of Science Signaling's vast archive of articles related to neuroscience.
November 15, 2016: Science Signaling
https://www.readbyqxmd.com/read/27891018/legal-challenges-in-neurological-practice
#18
REVIEW
Sita Jayalakshmi, Sudhindra Vooturi
Clinical neuroscience has made tremendous advances over the last century. Neurology as a discipline is still considered challenging and at times risky due to the natural history and progressive course of few of the neurological diseases. Encouragingly, the patient and their caregivers are now increasingly willing to be actively involved in making decisions. The patients' relationship with the doctor is a reflection of the society. A society that is orienting itself toward "rating" and "feedback" has made this doctor-patient relationship, a consumer-service provider relationship...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27884966/setting-up-a-neuroscience-stroke-and-rehabilitation-centre-in-brunei-darussalam-by-a-transcontinental-on-site-and-telemedical-cooperation
#19
U Meyding-Lamadé, B Bassa, E Craemer, C Jacobi, C Chan, W Hacke, B Kress
Due to the world-wide aging population, there is a need for specialist neurological knowledge, treatment and care. Stroke treatment is effective in reducing mortality and disability, but it is still not available in many areas of the world. We describe the set-up process of a specialized Neuroscience, Stroke and Rehabilitation Centre in Brunei Darussalam (BNSRC) in cooperation with a German hospital. This study details the setup of a stroke-, neurological intensive care- and neurorehabilitation unit, laboratories and a telemedical network to perform all evidence-based stroke treatments...
November 24, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27876662/-views-on-careers-in-clinical-neurosciences-amongst-neurosurgeons-and-neurologists-in-china
#20
Rimas V Lukas, Chao Ma, Jingcao Chen, Hongmei Dong, Jinxin Li, Zefen Wang, Ivy Jiang, Kai Fu, Samita Satnarayan, Dara V F Albert, Renslow Sherer
BACKGROUND: China has a large and aging population. The need for physicians with training in clinical neurosciences will grow. Currently there is little known regarding the factors which lead physicians in China to pursue careers in clinical neurosciences. OBJECTIVES: The objective of this study is to garner a clearer understanding of the factors which impact physicians to pursue careers in neurosurgery and neurology in China. METHODS: We surveyed attendees at a national neuroscience conference on the factors which influence their pursuit of careers in clinical neurosciences...
November 19, 2016: World Neurosurgery
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