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https://www.readbyqxmd.com/read/29362511/neuropsychiatric-phenotypes-produced-by-gaba-reduction-in-mouse-cortex-and-hippocampus
#1
Stefan M Kolata, Kazuhito Nakao, Vivek Jeevakumar, Emily L Farmer-Alroth, Yuko Fujita, Aundrea F Bartley, Sunny Zhihong Jiang, Gregory R Rompala, Robert E Sorge, Dennisse V Jimenez, Keri Martinowich, Yolanda Mateo, Kenji Hashimoto, Lynn E Dobrunz, Kazu Nakazawa
Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically ablated from ~50% of cortical and hippocampal interneurons. Mutant mice showed a reduction of tissue GABA in the hippocampus and cortex including mPFC, and exhibited a cluster of effort-based behavior deficits including decreased home-cage wheel running and increased immobility in both tail suspension and forced swim tests...
December 6, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29354921/-clinical-therapeutic-effects-of-scraping-therapy-on-allergic-rhinitis-of-different-syndromes
#2
Hua Chen, Qiuqin Wang, Hongli An
OBJECTIVE: To compare the differences in the therapeutic effects on allergic rhinitis between scraping therapy and cetirizine and observe the differences in the clinical therapeutic effects of scraping therapy on the disease of different differentiated patterns/syndromes. METHODS: The included participants of allergic rhinitis were randomized into a western medication group and three scraping therapy groups, named a lung qi deficiency and cold group, a spleen qi deficiency group and a kidney yang deficiency group, 20 cases in each one...
September 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29318861/-clinical-trials-for-treatment-of-allergic-rhinitis-with-heat-sensitive-moxibustion-and-its-regularity-of-heat-sensitization-acupoint-distribution
#3
Yu-Fen Lin, Jian-Min Lu, Yan-Na Su, Ze-Bin Zhong, Zuo-Dan Zhang
OBJECTIVE: To observe the clinical effect of heat sensitive moxibustion (HSM) and its regularity of acupoint heat-sensitization in the treatment of allergic rhinitis (AR) patients. METHODS: Seventy patients with AR were randomly divided into HSM and manual acupuncture groups (n=35/group). For patients of the HSM group, acupoints Yintang (EX-HN 3), bilateral Yingxiang (LI 20), Shangxing (GV 23), Tongtian (BL 7), Feishu (BL 13), Hegu (LI 4), etc. were used, and for patients of the manual acupuncture group, bilateral LI 20 and LI 4, Bitong (EX-HN 8) and EX-HN 3 were needled and stimulated with uniform reinforcing-reducing needling method...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29287788/timeless2-plays-an-important-role-in-reproduction-and-circadian-rhythms-in-the-cricket-gryllus-bimaculatus
#4
Motoki Nose, Atsushi Tokuoka, Tetsuya Bando, Kenji Tomioka
The timeless2 (tim2) gene is an insect orthologue of the mammalian clock gene Timeless (mTim). Although its functional role has been extensively studied in mammals, little is known regarding its role in insects. In the present study, we obtained tim2 cDNA (Gb'tim2) from the cricket Gryllus bimaculatus and characterized its functional role in embryonic development, egg production, and circadian rhythms. Gb'tim2 gave rise to a 1432 amino acid protein, and showed approximately 65% homology to that of Drosophila melanogaster...
December 26, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29133824/comparison-and-evaluation-of-two-different-methods-to-establish-the-cigarette-smoke-exposure-mouse-model-of-copd
#5
Jiaze Shu, Defu Li, Haiping Ouyang, Junyi Huang, Zhen Long, Zhihao Liang, Yuqin Chen, Yiguan Chen, Qiuyu Zheng, Meidan Kuang, Haiyang Tang, Jian Wang, Wenju Lu
Animal model of cigarette smoke (CS) -induced chronic obstructive pulmonary disease (COPD) is the primary testing methodology for drug therapies and studies on pathogenic mechanisms of disease. However, researchers have rarely run simultaneous or side-by-side tests of whole-body and nose-only CS exposure in building their mouse models of COPD. We compared and evaluated these two different methods of CS exposure, plus airway Lipopolysaccharides (LPS) inhalation, in building our COPD mouse model. Compared with the control group, CS exposed mice showed significant increased inspiratory resistance, functional residual capacity, right ventricular hypertrophy index, and total cell count in BALF...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021092/t-cells-and-their-cytokine-production-the-anti-inflammatory-and-immunosuppressive-effects-of-strenuous-exercise
#6
REVIEW
David M Shaw, Fabrice Merien, Andrea Braakhuis, Deborah Dulson
Strenuous exercise bouts and heavy training are associated with a heightened anti-inflammatory state and a transient suppression of several immune components. In turn, many athletes are susceptible to illness, particularly upper respiratory symptoms (e.g. cough, sore throat, running nose). T-lymphocytes (T-cells) are important for orchestrating the immune response and can be categorised into subsets according to their phenotypical characteristics resulting from polarisation (i.e. type-1, type-2 and regulatory T-cells)...
October 8, 2017: Cytokine
https://www.readbyqxmd.com/read/29017874/temporal-relationships-between-food-acquisition-and-voluntary-exercise-in-mice
#7
Neil E Rowland, Melissa R Cervantez, Kimberly L Robertson
Patterns of operant food acquisition in a closed economy and bouts of either voluntary wheel running (WR) or spontaneous locomotor activity in a standard condition (SC) with no wheel were examined in young adult male and female C57BL/6 mice across a range of nose poke prices (FUP) per food pellet. Both sexes showed vigorous WR or locomotor activity. At each FUP, WR groups had higher food intake than SC groups. Despite substantially higher mean body weight of males compared with females, intakes and activity did not differ by sex in the SC groups and males lost weight more rapidly as FUP increased...
October 7, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28857369/direct-analysis-of-volatile-organic-compounds-in-foods-by-headspace-extraction-atmospheric-pressure-chemical-ionisation-mass-spectrometry
#8
P Perez-Hurtado, E Palmer, T Owen, C Aldcroft, M H Allen, J Jones, C S Creaser, M R Lindley, M A Turner, J C Reynolds
RATIONALE: The rapid screening of volatile organic compounds (VOCs) by direct analysis has potential applications in the areas of food and flavour science. Currently, the technique of choice for VOC analysis is gas chromatography/mass spectrometry (GC/MS). However, the long chromatographic run times and elaborate sample preparation associated with this technique have led a movement towards direct analysis techniques, such as selected ion flow tube mass spectrometry (SIFT-MS), proton transfer reaction mass spectrometry (PTR-MS) and electronic noses...
November 30, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28660774/canalis-basalis-medianus-with-cerebrospinal-fluid-leak-rare-presentation-and-literature-review
#9
Sami Khairy, Abdulaziz Oqalaa Almubarak, Ahmed Aloraidi, Khalid Omar Awad Alahmadi
Canalis Basalis Medianus is a rare congenital normal anatomically variant of the clivus .We report a very rare case of cerebrospinal fluid leak from a canalis basilaris medianus in a 22-year-old male, who presented to our hospital with frontal headache and running nose two weeks after an elective septoplasty.
June 29, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28577016/clinical-and-epidemiological-characterization-of-influenza-a-h1n1pdm-and-b-among-hospitalized-children-georgia-season-2010-2011
#10
A Machablishvili, D Tsereteli, Kh Zakhashvili, I Karseladze, P Imnadze
The aim of the study was to describe, analyze and compare clinical and epidemiological characteristics of laboratory confirmed influenza A(H1N1)pdm and B cases in hospitalized children during post pandemic season. Between 1st January and 1st May, 2011 retrospective observational study was conducted in M. Iashvili Children's Central Hospital. From 1028 patients with influenza like illness hospitalized at Children's Hospital 871 specimens were collected and 360 tested positive for influenza: A(H1N1)pdm - 139 and B - 221...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28556243/anatomical-study-of-the-internal-nasal-branch-of-the-infraorbital-nerve-application-to-minimizing-nerve-damage-with-surgery-in-and-around-the-nose
#11
Joe Iwanaga, Koichi Watanabe, Brandon Henry, Krzysztof A Tomaszewski, Jerzy A Walocha, Rod J Oskouian, R Shane Tubbs
The internal nasal branch of the infraorbital nerve (ION) runs down the nose and around the ala to be distributed to the nasal septum and vestibule. The aim of this study was to measure the internal nasal branch around the ala of the nose and discuss its possible relevance in clinical/surgical practice. Twelve sides from seven specimens derived from fresh frozen and embalmed Caucasian cadaveric heads were dissected. The specimens included three males and four females. The ages of the cadavers at death ranged from 65 to 84 years...
September 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28463058/generating-facial-expressions-of-disgust-activates-neurons-in-the-thoracic-spinal-cord-a-spinal-fmri-study
#12
Stephen D Smith, Jennifer Kornelsen, Theresa A McIver
Facial expressions of disgust, which involve movement of the levator labii muscles on the nose, allow an organism to restrict the intake of potentially aversive stimuli by constricting the air cavities in the nostrils and reducing the speed of air intake. In the current research, we used fMRI of the thoracic spinal cord to measure neural activity related to (1) the contraction of the intercostal muscles that modulate the velocity of air intake and (2) the sensory feedback associated with this contraction. Thirteen participants completed two spinal fMRI runs in which the thoracic segments of the spinal cord were measured...
May 8, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28379190/assessment-of-the-indoor-odour-impact-in-a-naturally-ventilated-room
#13
Lidia Eusebio, Marco Derudi, Laura Capelli, Giuseppe Nano, Selena Sironi
Indoor air quality influences people's lives, potentially affecting their health and comfort. Nowadays, ventilation is the only technique commonly used for regulating indoor air quality. CO₂ is the reference species considered in order to calculate the air exchange rates of indoor environments. Indeed, regarding air quality, the presence of pleasant or unpleasant odours can strongly influence the environmental comfort. In this paper, a case study of indoor air quality monitoring is reported. The indoor field tests were conducted measuring both CO₂ concentration, using a photoacoustic multi-gas analyzer, and odour trends, using an electronic nose, in order to analyze and compare the information acquired...
April 5, 2017: Sensors
https://www.readbyqxmd.com/read/28244843/a-simple-diagnostic-scale-based-on-the-analysis-and-screening-of-clinical-parameters-in-paediatric-obstructive-sleep-apnoea-hypopnea-syndrome
#14
D Wu, X Li, X Guo, J Qin, S Li
OBJECTIVE: This study aimed to develop a simple and accurate method to diagnose paediatric obstructive sleep apnoea hypopnea syndrome. METHODS: A total of 311 children with suspected paediatric obstructive sleep apnoea hypopnea syndrome were included in the study. Multiple clinical parameters, including sex, age, body mass index, history of snoring or gasping, history of nasal obstruction, history of running nose, palatine tonsil size, adenoid to nasopharynx ratio, and tympanogram type, were compared with polysomnography results using relevant correlation and regression analyses...
April 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28139171/correlation-between-subjective-nasal-patency-and-intranasal-airflow-distribution
#15
Kevin P Casey, Azadeh A T Borojeni, Lisa J Koenig, John S Rhee, Guilherme J M Garcia
Objectives (1) Analyze the relationship between intranasal airflow distribution and subjective nasal patency in healthy and nasal airway obstruction (NAO) cohorts using computational fluid dynamics (CFD). (2) Determine whether intranasal airflow distribution is an important objective measure of airflow sensation that should be considered in future NAO virtual surgery planning. Study Design Cross-sectional. Setting Academic tertiary medical center and academic dental clinic. Subjects and Methods Three-dimensional models of nasal anatomy were created based on computed tomography scans of 15 patients with NAO and 15 healthy subjects and used to run CFD simulations of nasal airflow and mucosal cooling...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28116549/run-hide-or-fight-anti-predation-strategies-in-endangered-red-nosed-cuxi%C3%A3%C2%BA-chiropotes-albinasus-pitheciidae-in-southeastern-amazonia
#16
Adrian A Barnett, João M Silla, Tadeu de Oliveira, Sarah A Boyle, Bruna M Bezerra, Wilson R Spironello, Eleonore Z F Setz, Rafaela F Soares da Silva, Samara de Albuquerque Teixeira, Lucy M Todd, Liliam P Pinto
Although primate predation is rarely observed, a series of primate anti-predation strategies have been described. Energetic costs of such strategies can vary from high-cost mobbing, via less costly alarm calling, to low-cost furtive concealment. Here we report the anti-predation strategies of red-nosed cuxiú, Chiropotes albinasus, based on direct observations from four study sites in southeastern Brazilian Amazonia. Over a collective period of 1255 fieldwork hours, we observed nine direct interactions between raptors (all potential predators) and red-nosed cuxiús...
April 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28047809/su-c-brc-07-parametrized-gpu-accelerated-electron-monte-carlo-second-check
#17
J Haywood
PURPOSE: I am presenting a parameterized 3D GPU accelerated electron Monte Carlo second check program. METHOD: I wrote the 3D grid dose calculation algorithm in CUDA and utilized an NVIDIA GeForce GTX 780 Ti to run all of the calculations. The electron path beyond the distal end of the cone is governed by four parameters: the amplitude of scattering (AMP), the mean and width of a Gaussian energy distribution (E and α), and the percentage of photons. In my code, I adjusted all parameters until the calculated PDD and profile fit the measured 10×10 open beam data within 1%/1mm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27974120/-influencing-factors-for-duration-of-viral-nucleic-acid-shedding-in-children-with-influenza-a
#18
Gao-Feng Zhou, Hong-Mei Wang, Rui-Mu Zhang, Ji-Kui Deng
OBJECTIVE: To investigate the features and duration of viral nucleic acid shedding in children with influenza A. METHODS: The clinical data of 90 children with influenza A with positive influenza A virus nucleic acid in nasopharyngeal swab detected by PCR were collected, and these children were divided into simple influenza A group (n=10), influenza A-pneumonia group (n=61), influenza A-nervous system damage group (n=10), and influenza A-underlying disease group (n=9)...
December 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27928962/neural-circuits-underlying-fly-larval-locomotion
#19
Hiroshi Kohsaka, Pierre A Guertin, Akinao Nose
Locomotion is a complex motor behavior that may be expressed in different ways using a variety of strategies depending upon species and pathological or environmental conditions. Quadrupedal or bipedal walking, running, swimming, flying and gliding constitute some of the locomotor modes enabling the body, in all cases, to move from one place to another. Despite these apparent differences in modes of locomotion, both vertebrate and invertebrate species share, at least in part, comparable neural control mechanisms for locomotor rhythm and pattern generation and modulation...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27659361/intraoperative-use-of-a-tablet-computer-to-aid-rhinoplasty
#20
M Tsounis, D Papadopoulou, C Faris
Open septorhinoplasty enables excellent exposure to the structural components of the nasal tip. Nevertheless, it runs the risk of weakening its support mechanisms, which can lead to notable changes to tip projection and rotation as well as to the nasolabial angle. It is therefore paramount that the surgeon reconstructs the nose to the desired endpoint at the end of the operation. Currently, the gold standard of care in rhinoplasty uses preoperative photographs with the patient sitting or standing. However, this is not a true representation of the face in the operative position as the patient is placed supine and so gravity affects the appearance of the nose in a different way...
January 2017: Annals of the Royal College of Surgeons of England
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