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Orbital neoplasms

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https://www.readbyqxmd.com/read/29334543/seminoma-metastatic-to-the-orbit
#1
Jonathan J Dutton, Alan D Proia
PURPOSE: Seminomas are solid tumors in young men, but which rarely metastasize to the orbit. The authors review the known literature on seminoma metastatic to the orbit, and describe an additional case in a 33-year-old man. METHODS: A literature search was performed on the MEDLINE database using keywords "seminoma," "testicular germ-cell tumors," "testicular cancer," "testicular neoplasm," "orbital metastasis," and "germ-cell neoplasms." RESULTS: Malignant neoplasms of the testis account for only 1% of cancers in men...
January 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29291204/embryonal-rhabdomyosarcoma-in-the-maxillary-sinus-with-orbital-involvement-in-a-pediatric-patient-case-report
#2
Ana Carolina Rodrigues de Melo, Tácio Candeia Lyra, Isabella Lima Arrais Ribeiro, Alexandre Rolim da Paz, Paulo Rogério Ferreti Bonan, Ricardo Dias de Castro, Ana Maria Gondim Valença
This report presents a case of embryonal rhabdomyosarcoma (eRMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral hospital. The images provided from the computed tomography showed a heterogeneous mass with soft-tissue density, occupying part of the left half of the face inside the maxillary sinus, and infiltrating and destroying the bone structure of the maxillary sinus, left orbit, ethmoidal cells, nasal cavity, and sphenoid sinus...
December 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29285193/orbital-alveolar-soft-part-sarcoma-a-report-of-8-cases-and-review-of-the-literature
#3
Yan Hei, Li Kang, Xinji Yang, Yi Wang, Xiaozhong Lu, Yueyue Li, Wei Zhang, Lihua Xiao
Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm. The incidence of orbital involvement is the highest in ASPS arising in the head and neck region. However, limited information is available regarding its clinical characteristics. The present study presents the clinical manifestations, imaging findings, pathological features, treatment strategies and prognosis records of 8 cases of orbital ASPS over the last 15 years in a single hospital, along with a review of the literature. Included were 3 male and 5 female patients, with the median age at presentation being 9...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29203441/therapeutic-targeting-of-oncogenic-transcription-factors-by-natural-products-in-eye-cancer
#4
REVIEW
Michelle G Zhang, John Y Lee, Ryan A Gallo, Wensi Tao, David Tse, Ravi Doddapaneni, Daniel Pelaez
Carcinogenesis has a multifactorial etiology, and the underlying molecular pathogenesis is still not entirely understood, especially for eye cancers. Primary malignant intraocular neoplasms are relatively rare, but delayed detection and inappropriate management contribute to poor outcomes. Conventional treatment, such as orbital exenteration, chemotherapy, or radiotherapy, alone results in high mortality for many of these malignancies. Recent sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve management...
December 1, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29192649/the-histopathology-of-erdheim-chester-disease-a-comprehensive-review-of-a-molecularly-characterized-cohort
#5
Neval Ozkaya, Marc K Rosenblum, Benjamin H Durham, Janine D Pichardo, Omar Abdel-Wahab, Meera R Hameed, Klaus J Busam, William D Travis, Eli L Diamond, Ahmet Dogan
Erdheim-Chester disease is a rare, non-Langerhans cell histiocytosis histologically characterized by multi-systemic proliferation of mature histiocytes in a background of inflammatory stroma. The disease can involve virtually any organ system; most commonly the bones, skin, retroperitoneum, heart, orbit, lung, and brain are affected. Although a histiocytic proliferation is the histological hallmark of the disease, a wide range of morphological appearances have been described as part of case studies or small series...
December 1, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29144839/distinguishing-benign-from-malignant-circumscribed-orbital-tumors-in-children
#6
Yufei Tu, Frederick A Jakobiec, Katherine Leung, Suzanne K Freitag
An orbital neoplasm in children is an uncommon clinical finding. Clinical suspicion should be based on many factors, including its location, the nature of onset, associated systemic signs and symptoms, family and social histories, examination findings, and radiographic characteristics. We present two cases of young children of similar age with a rapid-onset orbital mass. In both cases, a circumscribed round lesion was found in the superomedial orbit. An orbital schwannoma, a benign and usually slow growing tumor, was found in the first patient...
November 16, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29125145/the-2017-doyne-lecture-the-orbit-as-a-window-to-systemic-disease
#7
REVIEW
A A McNab
A very large number of disorders affect the orbit, and many of these occur in the setting of systemic disease. This lecture covers selected aspects of orbital diseases with systemic associations in which the author has a particular clinical or research interest. Spontaneous orbital haemorrhage often occurs in the presence of bleeding diatheses. Thrombosis of orbital veins and ischaemic necrosis of orbital and ocular adnexal tissues occur with thrombophilic disorders, vasculitis, and certain bacterial and fungal infections...
November 10, 2017: Eye
https://www.readbyqxmd.com/read/28905842/malignant-perivascular-epithelioid-cell-tumor-of-the-orbit-report-of-a-case-and-review-of-literature
#8
Md Shahid Alam, Bipasha Mukherjee, S Krishnakumar, Jyotirmay Biswas
Perivascular epithelioid cell tumor (PEComa) is a rare neoplasm considered to arise from myomelanocytic cell lineage. The uterus is reportedly the most common site to be involved. Orbital PEComa is extremely rare with only two cases reported till date. A 5-year-old male presented with a right medial orbital mass for the last 6 months. The patient was diagnosed with alveolar soft part sarcoma elsewhere. Magnetic resonance imaging features were suggestive of lymphangioma with bleeding. The excision biopsy revealed multiple tumor cells comprising epithelioid cells with clear cytoplasm, along with nuclear atypia and mitosis...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28905841/lacrimal-gland-myxoma
#9
Drushti Parikh, Bipasha Mukherjee
Myxomas are rare neoplasms of mesenchymal origin. Cases of conjunctival, corneal, and orbital myxomas have been reported in the literature; however, to the best of our knowledge, there is no report of a lacrimal gland myxoma. We report a case of an orbital myxoma involving the lacrimal gland and its management.
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28891704/mucoepidermoid-carcinoma-in-the-skull-of-an-orange-winged-amazon-parrot-amazona-amazonica
#10
Melissa R Nau, James W Carpenter, Denise Lin, Sanjeev Narayanan, Mackenzie Hallman
A 33-year-old female intact orange-winged Amazon parrot (Amazona amazonica) presented for a slowly growing mass over the right eye. A computed tomography scan performed with and without intravenous contrast revealed a heterogeneous mixed soft tissue and mineral-dense mass with a small area of non-contrast-enhancing fluid density located between the orbits at the caudal aspect of the nasal passages, with associated lysis of the right caudal nasal passage and the right frontal bone. Following euthanasia, the mass was found to consist of soft tissue between the right eye and nostril over the right frontal bone...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28889800/adenocarcinoma-of-the-lacrimal-gland-a-case-report
#11
Asmae Touil, Sarah El Abbassi, Yassine Echchikhi, Mustapha Maher, Tayeb Kebdani, Noureddine Benjaafar
BACKGROUND: Primary ductal adenocarcinomas of the lacrimal gland are very rare. This neoplasm shares some histological and immunohistochemical similarities with salivary duct carcinoma. CASE PRESENTATION: Here, we present a case of a 55-year-old Moroccan man with lacrimal gland adenocarcinoma. He underwent orbital exenteration with lymph nodes dissection and ipsilateral parotidectomy. After surgery, he was lost to follow-up and died 13 months later. CONCLUSIONS: Lacrimal gland tumors are rare but highly aggressive salivary gland tumors...
September 11, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28882848/orbital-recurrence-of-iris-melanoma-21-years-after-enucleation
#12
Emilie Bergeron, Nadia Lihimdi, Dan Bergeron, Solange Landreville
We present the case of a 56-year-old man who developed a neoplasm of epithelioid histology in his anophthalmic left orbit 21 years after he underwent enucleation for a spindle cell iris melanoma. The recurrent tumour was managed by orbital exenteration. Neither further recurrence nor metastasis was diagnosed over a 5-year follow-up period. This case, along with five other similar cases in the literature,(1-3) emphasises the importance of long-term follow-up after treatment of iris melanoma.
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28862213/profile-of-eyelid-malignancy-in-a-tertiary-health-care-center-in-north-india
#13
Priyanka Gupta, Ramesh Chandra Gupta, Lubna Khan
CONTEXT: The eyelids are affected by wide spectrum of benign and malignant lesions. Basal cell carcinoma (BCC) is the most common malignancy encountered while other malignant lesions such as sebaceous cell carcinoma and squamous cell carcinoma are rare. Data regarding geographical variation in trends of malignant eyelid tumors are presented in the current study. SETTINGS AND DESIGN: Prospective, longitudinal, observational study was conducted from December 2011 to October 2013...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28844052/multicentred-international-review-of-orbital-exenteration-and-reconstruction-in-oculoplastic-and-orbit-practice
#14
Ze Zhang, Son Ho, Vivian Yin, Gonzalo Varas, Saul Rajak, Peter J Dolman, Alan McNab, J Godfrey Heathcote, Alejandra Valenzuela
BACKGROUND: Orbital exenteration is a disfiguring procedure reserved for life-threatening malignancies. This study examines the clinical course and outcomes of a large series of patients who underwent orbital exenteration for malignant periocular neoplasms. METHODS: This is a retrospective review of patients who underwent orbital exenteration from 1 July 2005 to 30 June 2015 at four tertiary referral centres in the USA, Australia and Canada. Demographics, indication for surgery, pathology, surgical technique, reconstruction type and outcomes were reviewed...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28832740/solitary-fibrous-tumor-of-the-lacrimal-gland-mimicking-pleomorphic-adenoma
#15
Eduardo Damous Feijó, Ana Carla de Souza Nery, Fábio Ramos Caiado, Roberto Murillo Limongi
Solitary fibrous tumor (SFT) is a rare mesenchymal spindle-cell neoplasm commonly found in the pleura; it is rare in the orbit and extremely rare in the lacrimal gland. We herein report a case of SFT of the lacrimal gland that mimicked a pleo morphic adenoma. We discuss the clinical, radiological, histopathological, and immunohistochemical findings that provided insight and rationale to accurately diagnose this case.
June 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28821195/atypical-igg4-plasmacytic-proliferations-and-lymphomas-characterization-of-11-cases
#16
Jacob R Bledsoe, Zachary S Wallace, Vikram Deshpande, Joshua R Richter, Jason Klapman, Andrew Cowan, John H Stone, Judith A Ferry
Objectives: To report the clinicopathologic features of monotypic immunoglobulin G4+ (IgG4+) lymphoid and plasmacytic proliferations. Methods: Cases were identified from the pathology files. Pathology and clinical materials were reviewed. Results: Eleven cases of monotypic IgG4+ proliferations were identified at nodal, orbital, or salivary sites. Six cases (three men, three women; age, 57-94 years) met criteria for lymphoma or plasma cell neoplasia...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28820163/sympathetic-ophthalmia-related-to-conjunctival-invasive-squamous-cell-carcinoma
#17
Inês Leal, David Cordeiro Sousa, Cláudia Loureiro, Ana Fonseca
Sympathetic ophthalmia (SO) is a rare, diffuse, bilateral, and granulomatous nonnecrotizing panuveitis that may follow intraocular penetrating trauma. Our aim is to report a rare case of SO following orbital exenteration. Orbital exenteration was performed on a 48-year-old african female due to conjunctival keratinizing squamous cell carcinoma with intraocular involvement of the left eye. Five days after the uneventful procedure, the patient presented signs and symptoms compatible with SO. Key differential diagnoses were excluded, and prompt and aggressive immunosuppression was started with a favourable but slow clinical response...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28817996/meningioma-with-tyrosine-rich-crystalloids-a-case-report-and-review-of-the-literature
#18
Erik Reinertsen, Stewart G Neill, Kambiz Nael, Daniel J Brat, Costas G Hadjipanayis
We report a case of fibrous meningioma with tyrosine-rich crystalloid in the frontal lobe of a middle-aged woman. The patient presented with a history of several years of worsening headaches and blurry vision, which progressed to include syncopal episodes and right-sided weakness. Imaging demonstrated a dural-based extra-axial mass arising from the right orbital roof and extending superiorly along the right frontal convexity causing right-to-left midline shift. The patient underwent a craniotomy and operative resection...
August 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28799731/rhinology-specific-priority-setting-for-quality-improvement-a-modified-delphi-study-from-the-quality-improvement-committee-of-the-american-rhinologic-society
#19
Luke Rudmik, Jose L Mattos, Janalee K Stokken, Zachary M Soler, R Peter Manes, Thomas S Higgins, Michael Setzen, Jivianne Lee, John Schneider
BACKGROUND: Improving the quality of healthcare is a complex and resource intensive process. To optimize the allocation of scarce resources, quality improvement (QI) should focus on high-value diseases that will produce the largest improvement in health system performance. Given the breadth and multidisciplinary nature of sinonasal disease management, the purpose of this study was to transparently develop a prioritized list of sinonasal diseases for QI from the perspective of the specialty of rhinology and the American Rhinologic Society (ARS)...
October 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28719711/ct-and-mri-features-in-adult-patients-with-orbital-subperiosteal-abscess-secondary-to-paranasal-sinus-mucocele
#20
Chang-Wei Ding, Qiu-Shi Wang, Qi-Yong Guo, Jun Zhang, Zhen-Hai Wang
Orbital subperiosteal abscess (OSPA) secondary to paranasal sinus mucocele (PSM) is rare, and it may be misdiagnosed as PSM with orbital invasion or even as a malignant neoplasm. The present study explored the computed tomography (CT) and magnetic resonance imaging (MRI) features of OSPA. The cases of 13 patients with OSPA secondary to PSM were retrospectively reviewed. CT had been performed in 12, MRI in 7, and postcontrast MRI in 4. OSPA was revealed as a well-demarcated, spindle-shaped mass that was broad-based and located beneath the superior orbital wall (orbital roof) in 11 and at the medial wall in 2...
July 2017: Ear, Nose, & Throat Journal
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