keyword
https://read.qxmd.com/read/38542701/probiotic-consortium-confers-synergistic-anti-inflammatory-effects-in-inflammatory-disorders
#1
JOURNAL ARTICLE
Changhon Lee, Seung Won Kim, Ravi Verma, Jaegyun Noh, John Chulhoon Park, Sunhee Park, Haena Lee, Hye Eun Park, Chan Johng Kim, Seohyun Byun, Haeun Ko, Seungyeon Choi, Inhae Kim, Soomin Jeon, Junglyoul Lee, Sin-Hyeog Im
The composition and diversity of gut microbiota significantly influence the immune system and are linked to various diseases, including inflammatory and allergy disorders. While considerable research has focused on exploring single bacterial species or consortia, the optimal strategies for microbiota-based therapeutics remain underexplored. Specifically, the comparative effectiveness of bacterial consortia versus individual species warrants further investigation. In our study, we assessed the impact of the bacterial consortium MPRO, comprising Lactiplantibacillus plantarum HY7712, Bifidobacterium animalis ssp...
March 11, 2024: Nutrients
https://read.qxmd.com/read/38542109/differential-impact-of-cd43-and-cd28-on-t-cell-differentiation-depending-on-the-order-of-engagement-with-the-tcr
#2
JOURNAL ARTICLE
Monserrat Alba Sandoval-Hernández, Nora Alma Fierro, José Ignacio Veytia-Bucheli, Den Alejandro Alvarado-Velázquez, Estefanía Alemán-Navarro, Erika Melchy-Pérez, Constance Auvynet, Iván Imaz-Rosshandler, Jorge Carneiro, Ernesto Perez-Rueda, Yvonne Rosenstein
The combination of signals from the T-cell receptor (TCR) and co-stimulatory molecules triggers transcriptional programs that lead to proliferation, cytokine secretion, and effector functions. We compared the impact of engaging the TCR with CD28 and/or CD43 at different time points relative to TCR engagement on T-cell function. TCR and CD43 simultaneous engagement resulted in higher CD69 and PD-1 expression levels than in TCR and CD28-stimulated cells, with a cytokine signature of mostly effector, inflammatory, and regulatory cytokines, while TCR and CD28-activated cells secreted all categories of cytokines, including stimulatory cytokines...
March 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542056/dark-under-the-lamp-neglected-biological-pollutants-in-the-environment-are-closely-linked-to-lung-cancer
#3
REVIEW
Dongjie Wang, Ben Chung-Lap Chan, Bitian Zhang, Katie Ching-Yau Wong, Lea Ling-Yu Kan, Chun-Kwok Wong
Environmental pollutants are closely linked to lung cancer. The different types of environmental pollutants can be classified as chemical, physical, and biological. The roles of common chemical and physical pollutants such as PM2.5, smoking, radon, asbestos, and formaldehyde in lung cancer have been extensively studied. Notably, the worldwide COVID-19 pandemic raised awareness of the strong link between biological pollution and human health. Allergens such as house dust mites and pollen, as well as bacteria and viruses, are common biological pollutants...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38536204/the-impact-of-a-pandemic-on-a-military-oral-and-maxillofacial-pathology-biopsy-service
#4
JOURNAL ARTICLE
Trevor E Miller, Noel E Dickens, Matthew R Rehmel, Bradley E Jones, Nicholas J Hamlin, Quinn C Robbins
INTRODUCTION: Coronavirus disease 2019 (COVID-19) and the resulting societal reaction presented new challenges to the medical community by limiting patient access to care in 2020 and 2021. The Navy Postgraduate Dental School (NPDS) oral and maxillofacial pathology biopsy service is dependent on in-office physician or dentist appointments and patient biopsies. The purpose of this study was to understand the regulatory and societal impacts of COVID-19 restrictions on biopsy service submissions by assessing NPDS biopsy submission quantities and disease distribution...
March 25, 2024: Military Medicine
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#5
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38532599/high-sensitivity-of-host-helios-neuropilin-1-treg-to-pretransplant-conditioning-hampers-development-of-ox40-bright-integrin-%C3%AE-7-regulatory-cells-in-acute-gastrointestinal-gvhd
#6
JOURNAL ARTICLE
Nikolett Lupsa, Barbara Érsek, Csenge Böröczky, Dávid Kis, Eszter Szarka, Katalin Lumniczky, Géza Sáfrány, Zoltán S Zádori, Árpád Szöőr, Edit I Buzás, Zoltán Pós
This study sought to compare the behavior of Treg subsets displaying different coexpression patterns of Neuropilin-1 (Nrp1) and Helios, under the influence of gut stress unrelated to hematopoietic stem cell transplantation, pretransplantation conditioning, and posttransplant gastrointestinal acute graft versus host disease (GI-aGvHD). Host CD4+ /CD25hi /Foxp3+ Treg cells, identified by flow cytometry, were isolated from various tissues of mice affected by these stressors. Expression of CD25, CTLA-4, CD39, OX40, integrin-β7, LAG3, TGFβ/LAP, granzyme-A, -B, and interleukin-10 was compared in four Treg subsets displaying Helios or Nrp1 only, both or none...
March 26, 2024: European Journal of Immunology
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#7
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530780/effects-of-interleukin-6-signal-inhibition-on-treg-subpopulations-and-association-of-tregs-with-clinical-outcomes-in-rheumatoid-arthritis
#8
JOURNAL ARTICLE
Hiroto Yoshida, Mayu Magi, Hiroya Tamai, Jun Kikuchi, Keiko Yoshimoto, Kotaro Otomo, Yoshihiro Matsumoto, Mariko Noguchi-Sasaki, Tsutomu Takeuchi, Yuko Kaneko
OBJECTIVES: Anti-IL-6 receptor antibodies are clinically efficacious in the management of rheumatoid arthritis (RA) with an associated increase in regulatory T cells (Tregs); however, the role of functional Treg subsets has yet to be clarified. This study aimed to evaluate how functional Treg subsets are altered by IL-6 receptor blockade and to analyze the relationship between these Treg subsets and the clinical outcome of RA. METHODS: We collected frozen peripheral blood mononuclear cells (PBMCs) from 40 patients with RA who started tocilizumab (TCZ) with or without MTX and 11 healthy controls (HCs)...
March 26, 2024: Rheumatology
https://read.qxmd.com/read/38526805/ox40-ox40-ligand-and-its-role-in-precision-immune-oncology
#9
REVIEW
Bicky Thapa, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Suzanna Lee, Mary K Nesline, Rebecca A Previs, Jeffery M Conroy, Paul DePietro, Sarabjot Pabla, Razelle Kurzrock
Immune checkpoint inhibitors have changed the treatment landscape for various malignancies; however, their benefit is limited to a subset of patients. The immune machinery includes both mediators of suppression/immune evasion, such as PD-1, PD-L1, CTLA-4, and LAG-3, all of which can be inhibited by specific antibodies, and immune-stimulatory molecules, such as T-cell co-stimulatory receptors that belong to the tumor necrosis factor receptor superfamily (TNFRSF), including OX40 receptor (CD134; TNFRSF4), 4-1BB (CD137; TNFRSF9), and glucocorticoid-induced TNFR-related (GITR) protein (CD357; TNFRSF18)...
March 25, 2024: Cancer Metastasis Reviews
https://read.qxmd.com/read/38520894/quantification-of-cd3-foxp3-and-granzyme-b-immunostaining-in-canine-renal-cell-carcinoma
#10
JOURNAL ARTICLE
Ashleigh Cournoyer, Hayley Amerman, Charles-Antoine Assenmacher, Amy Durham, James A Perry, Allison Gedney, Nicholas Keuler, Matthew J Atherton, Jennifer A Lenz
Tumor-infiltrating lymphocyte (TIL) density plays an important role in anti-tumor immunity and is associated with patient outcome in various human and canine malignancies. As a first assessment of the immune landscape of the tumor microenvironment in canine renal cell carcinoma (RCC), we retrospectively analyzed clinical data and quantified CD3, FoxP3, and granzyme B immunostaining in formalin-fixed paraffin-embedded tumor samples from 16 dogs diagnosed with renal cell carcinoma treated with ureteronephrectomy...
March 16, 2024: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38519055/molecular-assessment-of-intratumoral-immune-cell-subsets-and-potential-mechanisms-of-resistance-to-odronextamab-a-cd20%C3%A3-cd3-bispecific-antibody-in-patients-with-relapsed-refractory-b-cell-non-hodgkin-lymphoma
#11
JOURNAL ARTICLE
Jurriaan Brouwer-Visser, Nathalie Fiaschi, Raquel P Deering, Kamil J Cygan, Darius Scott, Se Jeong, Lauren Boucher, Namita T Gupta, Suraj Gupta, Christina Adler, Max S Topp, Rajat Bannerji, Johannes Duell, Ranjana H Advani, Dina M Flink, Aafia Chaudhry, Gavin Thurston, Srikanth R Ambati, Vladimir Jankovic
BACKGROUND: Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via T-cell-mediated cytotoxicity independent of T-cell/major histocompatibility complex interaction. Phase I results in patients with R/R B-NHL demonstrated that odronextamab monotherapy could achieve deep and durable responses with a generally manageable safety profile (ELM-1; NCT02290951)...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38519032/the-balance-between-nuclear-import-and-export-of-nlrc5-regulates-mhc-class-i-transactivation
#12
JOURNAL ARTICLE
Baohui Zhu, Ryota Ouda, Ning An, Tsutomu Tanaka, Koichi S Kobayashi
MHC (major histocompatibility complex) class I molecules play an essential role in regulating the adaptive immune system by presenting antigens to CD8 T cells. CITA (MHC class I transactivator), also known as NLRC5 (NLR family, CARD domain-containing 5), regulates the expression of MHC class I and essential components involved in the MHC class I antigen presentation pathway. While the critical role of the nuclear distribution of NLRC5 in its transactivation activity has been known, the regulatory mechanism to determine the nuclear localization of NLRC5 remains poorly understood...
March 20, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38517294/antibody-suppressor-cxcr5-cd8-t-cells-are-more-potent-regulators-of-humoral-alloimmunity-after-kidney-transplant-in-mice-compared-to-cd4-regulatory-t-cells
#13
JOURNAL ARTICLE
Jing L Han, Jason M Zimmerer, Qiang Zeng, Sachi Chaudhari, Anjali Satoskar, Mahmoud Abdel-Rasoul, Hope Uwase, Christopher K Breuer, Ginny L Bumgardner
Adoptive cell therapy (ACT), especially with CD4+ regulatory T cells (CD4+ Tregs), is an emerging therapeutic strategy to minimize immunosuppression and promote long-term allograft acceptance, although much research remains to realize its potential. In this study, we investigated the potency of novel Ab-suppressor CXCR5+CD8+ T cells (CD8+ TAb-supp) in comparison with conventional CD25highFoxp3+CD4+ Tregs for suppression of humoral alloimmunity in a murine kidney transplant (KTx) model of Ab-mediated rejection (AMR)...
March 22, 2024: Journal of Immunology
https://read.qxmd.com/read/38517196/heat-non-heat-treatment-alleviate-%C3%AE-conglycinin-triggered-food-allergy-reactions-by-modulating-the-th1-th2-immune-balance-in-a-balb-c-mouse-model
#14
JOURNAL ARTICLE
Tanghao Li, Guanhao Bu, Yixuan Chen, Qingqing Zhao, Yongfeng Chang
BACKGROUND: With the increasing popularity of plant protein-based diets, soy proteins are favored as the most important source of plant protein worldwide. However, potential food allergy risks limit their use in the food industry. This work aims to reveal the mechanism of β-conglycinin-induced food allergy, and to explore the regulatory mechanism of heat treatment and high hydrostatic pressure (HHP) treatment in a BALB/c mouse model. RESULTS: Our results showed that oral administration of β-conglycinin induced severe allergic symptoms in BALB/c mice, but these symptoms were effectively alleviated through heat treatment and HHP treatment...
March 22, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38514921/high-fat-diet-induced-obesity-causes-intestinal-th17-treg-imbalance-that-impairs-the-intestinal-barrier-and-aggravates-anxiety-like-behavior-in-mice
#15
JOURNAL ARTICLE
Yao Cai, Wenlin Deng, Qiuping Yang, Guixian Pan, Zao Liang, Ximei Yang, Sitao Li, Xin Xiao
The prevalence of autism spectrum disorders (ASD) has been steadily increasing, and growing evidence suggests a link between high-fat diet (HFD), obesity, and ASD; however, the mechanism underlying this association remains elusive. Herein, BTBR T + tf/J (BTBR) inbred mice (a mouse ASD model) and C57Bl/6J (C57) mice were fed an HFD and normal diet (ND) for 8 weeks (groups: C57 + ND, C57 + HFD, BTBR + ND, and BTBR + HFD). Subsequently, mice underwent behavioral assessments, followed by intestinal tissues harvesting to detect expression of intestinal barrier proteins and inflammatory factors and immune cell numbers, and a correlation analysis...
March 30, 2024: International Immunopharmacology
https://read.qxmd.com/read/38514903/the-lack-of-either-irf9-or-stat2-has-surprisingly-little-effect-on-human-natural-killer-cell-development-and-function
#16
JOURNAL ARTICLE
Ane Calvo-Apalategi, Marta López Nevado, Luz Yadira Bravo-Gallego, Luis Ignacio González-Granado, Luis M Allende, Rebeca Rodríguez Pena, Eduardo López-Granados, Hugh T Reyburn
Analysis of genetically defined immunodeficient patients allows study of the effect of the absence of specific proteins on human immune function in real-world conditions. Here we have addressed the importance of type I interferon signalling for human NK cell development by studying the phenotype and function of circulating NK cells isolated from patients suffering primary immunodeficiency disease due to mutation of either the human interferon regulatory factor 9 (IRF9) or the signal transducer and activator of transcription 2 (STAT2) genes...
March 21, 2024: Immunology
https://read.qxmd.com/read/38513626/purified-free-mannan-promotes-tolerogenic-responses-in-peanut-stimulated-human-dendritic-cells
#17
Silvia Sánchez-Herrero, Cristina Benito-Villalvilla, Oscar Palomares
INTRODUCTION: IgE-mediated peanut allergy is an important public health problem of increasing prevalence leading to anaphylactic reactions both in children and adults. Allergen-specific oral immunotherapy (OIT) is the single treatment with the potential capacity to modify the course of the disease, but it still faces some drawbacks in terms of efficacy, safety, patients' adherence, and cost. Alternative strategies, including the use of novel adjuvants, to overcome such limitations are highly demanded...
March 21, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38513610/constans-a-hub-for-all-seasons-how-photoperiod-pervades-plant-physiology-regulatory-circuits
#18
JOURNAL ARTICLE
Jose M Romero, Gloria Serrano-Bueno, Carolina Camacho-Fernández, Mateus Henrique Vicente, M Teresa Ruiz, J Román Pérez-Castiñeira, Javier Pérez-Hormaeche, Fabio T S Nogueira, Federico Valverde
How does a plant detect the changing seasons and make important developmental decisions accordingly? How do they incorporate daylength information into their routine physiological processes? Photoperiodism, or the capacity to measure the daylength, is a crucial aspect of plant development that helps plants determine the best time of the year to make vital decisions, such as flowering. The protein CONSTANS (CO) constitutes the central regulator of this sensing mechanism, not only activating florigen production in the leaves but also participating in many physiological aspects in which seasonality is important...
March 21, 2024: Plant Cell
https://read.qxmd.com/read/38512803/what-is-the-relevance-of-foxp3-in-the-tumor-microenvironment-and-cancer-outcomes
#19
JOURNAL ARTICLE
Abdo Meyiah, Eyad Elkord
INTRODUCTION: Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradictory results...
March 21, 2024: Expert Review of Clinical Immunology
https://read.qxmd.com/read/38511768/serum-autophagy-related-gene-5-level-in-stroke-patients-correlation-with-cd4-t-cells-and-cognition-impairment-during-a-3-year-follow-up
#20
JOURNAL ARTICLE
Juanjuan Qu, Linxia Wu, Meng Zhang, Minchen Kan, Huimin Chen, Yanqing Shi, Shuangyu Wang, Xiaohua Wang, Fan Chen
Autophagy-related gene (ATG) 5 regulates blood lipids, chronic inflammation, CD4+ T-cell differentiation, and neuronal death and is involved in post-stroke cognitive impairment. This study aimed to explore the correlation of serum ATG5 with CD4+ T cells and cognition impairment in stroke patients. Peripheral blood was collected from 180 stroke patients for serum ATG5 and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cell detection via enzyme-linked immunosorbent assays and flow cytometry. The Mini-Mental State Examination (MMSE) scale was completed at enrollment, year (Y)1, Y2, and Y3 in stroke patients...
2024: Brazilian Journal of Medical and Biological Research
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