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Sjogren's syndrome;biopsy

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https://www.readbyqxmd.com/read/28730224/histopathological-and-immunohistochemical-profile-in-primary-sj%C3%A3-gren-s-syndrome
#1
Ştefan Cristian Dinescu, Mircea Cătălin ForŢofoiu, Ana Maria Bumbea, Paulina Lucia Ciurea, Cristina Jana Busuioc, Anca Emanuela Muşetescu
Sjögren's syndrome (SS) is an autoimmune disease characterized by hypofunction of the salivary and lachrymal glands. Main clinical features of SS are sicca symptoms, due to the altered glandular function. Also, in advanced stages, bilateral swelling of the parotid glands can be noted, indicative of severe glandular involvement. Phenotypic expression of various mononuclear cells present in the affected tissue offers additional insight into cellular proliferation, survival, migration, antibody secretion and also the potential of forming tertiary lymphoid tissue, i...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28725949/tubulointerstitial-nephritis-induced-hypophosphatemic-osteomalacia-in-sj%C3%A3-gren-s-syndrome-a-case-report-and-review-of-the-literature
#2
REVIEW
Yan Geng, Youlu Zhao, Zhuoli Zhang
Sjögren's syndrome (SS) is a chronic autoimmune inflammatory disease that typically affects the salivary and lacrimal glands. Renal involvement is relatively uncommon and may precede other complaints. Tubulointestitial nephritis (TIN) is the most common renal involvement in SS. Osteomalacia occurring as the first manifestation of renal tubular disorder due to SS is very rare. We report a 39-year-old male who presented with polydipsia, polyuria, and multiple bone pain. Bone density test showed severe osteoporosis, and laboratory findings suggested hypokalemia, hypophosphatemia, and vitamin D deficiency, which supported the diagnosis of hypophosphatemic osteomalacia...
July 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28710097/germinal-centres-in-diagnostic-labial-gland-biopsies-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-are-not-predictive-for-parotid-malt-lymphoma-development
#3
Erlin A Haacke, Bert van der Vegt, Arjan Vissink, Fred K L Spijkervet, Hendrika Bootsma, Frans G M Kroese
OBJECTIVE: Patients with primary Sjögren's syndrome (pSS) have an increased risk of developing non-Hodgkin's lymphoma (NHL), particularly parotid gland mucosa-associated lymphoid tissue (MALT) lymphomas. Presence of germinal centres (GCs) in labial gland biopsies has been suggested as predictive factor for NHL. We assessed whether presence of GCs is increased in labial gland biopsies from patients with pSS who developed parotid MALT lymphoma, the dominant NHL-subtype in pSS, compared with patients with pSS who did not develop lymphoma...
July 14, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28690936/a-case-of-imatinib-induced-hepatitis
#4
Osman Bhatty, Mohammad Selim, Thamer Kassim, Lakshmi Chintalacheruvu, Manuel Urra, Sonia Shah, Joseph Haggerty, John Gross, Aravdeep Jhand, Gene Pershwitz, Jaya Gupta
A 71-year-old female with a past medical history of Philadelphia chromosome-positive chronic myelogenous leukemia on imatinib therapy, Sjogren's syndrome, and hypothyroidism presents with acute hepatitis. After a comprehensive workup ruling out viral, infectious and metabolic etiologies imatinib is stopped which results in immediate improvement. The biopsy is consistent with drug-induced liver damage; the patient is started on oral prednisone and discharged. Unfortunately, our patient's liver function does not improve over the course of the next week and she is readmitted for hepatic and renal failure...
June 1, 2017: Curēus
https://www.readbyqxmd.com/read/28686485/impaired-salivary-gland-activity-in-patients-with-autoimmune-polyendocrine-syndrome-type-i
#5
Bergithe E Oftedal, Mihaela Cuida Marthinussen, Martina M Erichsen, Maria K Tveitarås, Anja Kjellesvik-Kristiansen, Daniel Hammenfors, Malin V Jonsson, Kai Kisand, Roland Jonsson, Anette S B Wolff
Autoimmune polyendocrine syndrome type I (APS-I) is a severe disease caused by mutations in the autoimmune regulator (AIRE) gene. We hypothesized that salivary gland dysfunction could be a possible unexplored component of these patients and here aimed to investigate salivary and lachrymal symptoms in the Norwegian cohort of APS-I patients (N = 41) and the aetiology behind it. Sicca symptoms and possible corresponding underlying factors were assessed by subjective reports combined with objective measures of saliva and tear flow, serological testing, immune fluorescence microscopy, ultrasonography and searching for putative autoantibodies in the salivary glands...
July 7, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28666014/radiologic-pleuroparenchymal-fibroelastosis-like-lesion-in-connective-tissue-disease-related-interstitial-lung-disease
#6
Yasunori Enomoto, Yutaro Nakamura, Thomas V Colby, Takeshi Johkoh, Hiromitsu Sumikawa, Koji Nishimoto, Katsuhiro Yoshimura, Sayomi Matsushima, Yoshiyuki Oyama, Hironao Hozumi, Masato Kono, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Toshihide Iwashita, Takafumi Suda
BACKGROUND: Radiologic pleuroparenchymal fibroelastosis (PPFE)-like lesion including pulmonary apical cap can be occasionally observed in clinical settings. However, the significance of radiologic PPFE-like lesion is unclear in connective tissue disease (CTD)-related interstitial lung disease (ILD). MATERIALS AND METHODS: A total of 113 patients with CTD-related ILD were enrolled and assessed for radiologic PPFE-like lesion, which was defined as bilateral, upper lobe, and subpleural dense consolidations with or without pleural thickening on chest high-resolution computed tomography...
2017: PloS One
https://www.readbyqxmd.com/read/28648912/minor-salivary-gland-biopsy-an-important-contributor-to-the-diagnosis-of-sj%C3%A3-gren-syndrome
#7
Sarah Wicheta, Troy Van der Groen, William C Faquin, Meredith August
PURPOSE: Sjögren syndrome (SS), although commonly associated with xerostomia and xerophthalmia, can present with extraglandular manifestations that make definitive diagnosis difficult. The 2 leading diagnostic classification systems include a positive minor salivary gland biopsy (MSGB) result as a major inclusion criterion. The purpose of this study was to better define the role of the MSGB in establishing a diagnosis of SS in a cohort of referred patients. MATERIALS AND METHODS: This is a retrospective cohort study of patients referred to the Massachusetts General Hospital Department of Oral and Maxillofacial Surgery (Boston, MA) over a 5-year period to establish a diagnosis of SS...
May 30, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28648105/abnormal-distribution-of-aqp4-in-minor-salivary-glands-of-primary-sj%C3%A3-gren-s-syndrome-patients
#8
Margherita Sisto, Loredana Lorusso, Giuseppe Ingravallo, Beatrice Nico, Domenico Ribatti, Simona Ruggieri, Dario Domenico Lofrumento, Sabrina Lisi
A decreased saliva production occurs in primary Sjögren's syndrome (pSS), an autoimmune disease characterized by oral and ocular dryness due to dysfunction of the lacrimal and salivary glands (SGs). Since water movement is involved in saliva secretion, the expression, localization, and function of the water channels aquaporins (AQPs) have been extensively studied in SGs. To date, the presence of AQP4 remains controversial and ambiguous in human SGs. We investigated by immunohistochemistry, high-resolution confocal microscopy and quantitative image analysis, Western blot and real-time RT-PCR, the presence of the AQP4 gene, and the distribution of AQP4 protein in healthy controls and pSS SG biopsies...
June 24, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28597093/-pediatric-salivary-gland-tumors-and-tumor-like-lesions
#9
REVIEW
A Agaimy, H Iro, J Zenk
Salivary gland tumors and tumor-like lesions in the pediatric population are uncommon. They comprise a heterogeneous group of infectious/inflammatory and neoplastic conditions. Pediatric salivary neoplasms include benign tumors of mesenchymal or epithelial origin as well as malignancies of epithelial (carcinomas), mesenchymal (sarcoma) or hematolymphoid (lymphoma) derivation. Infectious/inflammatory conditions and hematolymphoid malignancies may represent either genuine parenchymal pathology or conditions involving intraglandular lymph nodes of the parotid glands (intraglandular lymphadenopathy and intraglandular nodal lymphomas)...
July 2017: Der Pathologe
https://www.readbyqxmd.com/read/28595240/toll-like-receptor-7-is-overexpressed-in-the-bladder-of-hunner-type-interstitial-cystitis-and-its-activation-in-the-mouse-bladder-can-induce-cystitis-and-bladder-pain
#10
Koji Ichihara, Naoki Aizawa, Yoshiyuki Akiyama, Jun Kamei, Naoya Masumori, Karl-Erik Andersson, Yukio Homma, Yasuhiko Igawa
Toll-like receptor 7 (TLR7) is associated with the pathophysiology of systemic lupus erythematosus and Sjögren syndrome, well-known diseases accompanying interstitial cystitis (IC). We studied TLR7 expression in the bladder of patients with Hunner-type IC (HIC) and its functional roles in bladder inflammation and nociception using mice. Bladder biopsy specimens were obtained from patients with HIC. Specimens from the noncancerous portion of the bladder of patients with bladder cancer served as controls. The specimens were examined by immunohistochemistry and real-time polymerase chain reaction of TLR7...
May 6, 2017: Pain
https://www.readbyqxmd.com/read/28577559/ectopic-germinal-center-and-megalin-defect-in-primary-sjogren-syndrome-with-renal-fanconi-syndrome
#11
Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L Lundquist, Limeng Chen
BACKGROUND: This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ectopic germinal center formation and megalin/cubilin down-expression. METHOD: Clinical and pathological records were reviewed. Immunohistochemistry was carried out to detect megalin, cubilin, CD21 and IL-17 expression...
June 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28556615/characteristics-of-germinal-center-like-structures-in-patients-with-sj%C3%A3-gren-s-syndrome
#12
Jing He, Yuebo Jin, Xia Zhang, Yunshan Zhou, Ru Li, Yijun Dai, Xiaolin Sun, Jingzhong Zhao, Jianping Guo, Zhanguo Li
AIM: To analyze the relationship between ectopic germinal centers (GCs) in the salivary glands and the clinical/laboratory characteristics of patients with Sjögren's syndrome (SS). METHODS: Retrospectively, 126 patients with primary SS (pSS) and 16 patients with secondary SS (sSS) were analyzed. Minor salivary gland biopsies were evaluated for the presence of GC-like morphology by hematoxylin and eosin (H&E) and immunohistochemical (IHC) staining for CD21. Clinical and serological data were obtained from medical records...
February 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28496965/malt-lymphoma-of-minor-salivary-glands-in-a-sj%C3%A3-gren-s-syndrome-patient-a-case-report-and-review-of-literature
#13
Savvas Titsinides, Nikolaos Nikitakis, Evangelia Piperi, Alexandra Sklavounou
BACKGROUND: Sjögren's syndrome is a chronic systemic disease, characterized by lymphocytic infiltration and destruction mainly of the salivary and lacrimal glands, resulting in xerostomia and xeropthalmia. Sjögren's syndrome patients have a 44-fold excess risk for the development of non-Hodgkin's lymphoma particularly mucosa-associated lymphoid tissue (MALT) lymphoma, prevalently affecting the major salivary glands. In this report, a rare case of MALT lymphoma of minor salivary glands in a patient with Sjögren's syndrome is described...
January 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/28450690/a-case-of-chronic-sarcoid-myopathy-with-basedow-s-disease-and-sjogren-s-syndrome-a-case-series-of-sarcoid-myopathy
#14
Takashi Isobe, Madoka Mori-Yoshimura, Yasushi Oya, Yuko Saito, Miho Murata, Ichizo Nishino, Yuji Takahashi
We report a 62-year-old woman with a history of Basedow's disease and Sjogren's syndrome who presented with slowly progressive limb muscle weakness over the course of ten years. On physical examination, she had dry eye and mouth, but was otherwise normal. Neurological examination revealed symmetrical proximal dominant muscle weakness. Polymyositis was suspected at initial diagnosis due to her clinical course, physical examination, and autoimmune disease. However, the final diagnosis based on a muscle biopsy was the chronic myopathic type of sarcoid myopathy...
April 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28445282/a-case-report-of-sj%C3%A3-gren-syndrome-manifesting-bilateral-basal-ganglia-lesions
#15
Bing Niu, Zhenzhen Zou, Yuqin Shen, Bingzhen Cao
RATIONALE: Peripheral neurological complications in primary Sjögren's syndrome (pSS) seem the most common, however the involvement of central nervous system (CNS) remains unclear. While abnormalities in pSS revealed by brain magnetic resonance imaging (MRI) are usually small discrete hyperintense areas in the white matter on T2-FLAIR weighted MRI, massive brain lesions have been rarely reported, particularly in bilateral basal ganglia. PATIENT CONCERNS: A 51-year-old woman exhibited dizziness, slurred speech and hemiplegia as a manifestation of pSS...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28439062/a-rare-case-of-necrotizing-myopathy-and-fibrinous-and-organizing-pneumonia-with-anti-ej-antisynthetase-syndrome-and-ssa-antibodies
#16
Muhammad Kashif, Divya Arya, Masooma Niazi, Misbahuddin Khaja
BACKGROUND Idiopathic inflammatory myopathies are autoimmune disorders that can involve the skin, joints, muscles, and lungs. The most common of these disorders are dermatomyositis, polymyositis, overlap syndrome, and inclusion body myositis. Necrotizing autoimmune myopathy is an idiopathic inflammatory myopathy that is rarely associated with Sjögren's syndrome. The most common lung findings associated with anti-EJ antisynthetase syndrome are nonspecific interstitial pneumonia and usual interstitial pneumonia; this condition is rarely associated with fibrinous and organizing pneumonia...
April 25, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28437595/natural-history-and-predictors-of-progression-to-sj%C3%A3-gren-s-syndrome-among-participants-of-the-sicca-registry
#17
Caroline H Shiboski, Alan N Baer, Stephen C Shiboski, Mi Lam, Stephen Challacombe, Hector E Lanfranchi, Morten Schiødt, Penelope Shirlaw, Muthiah Srinivasan, Hisanori Umehara, Frederick B Vivino, Esen Akpek, Vatinee Bunya, Cristina F Vollenweider, John S Greenspan, Troy E Daniels, Lindsey A Criswell
BACKGROUND/PURPOSE: To explore changes in the phenotypic features of Sjoögren's syndrome (SS), and in SS status among participants in the Sjoögren's International Collaborative Clinical Alliance (SICCA) registry over a 2 to 3-year interval. METHODS: All participants in the SICCA registry who were found to have any objective measures of salivary hypofunction, dry eye, focal lymphocytic sialadenitis in minor salivary gland biopsy, or anti-SSA/B antibodies, were recalled over a window of 2 to 3 years after their baseline examinations to repeat all clinical examinations and specimen collections to determine whether there was any change in phenotypic features and in SS status...
April 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28434265/adipose-tissue-infiltration-in-minor-salivary-glands-of-patients-with-sj%C3%A3-gren-s-syndrome-lack-of-significant-correlation-with-the-disease-an-image-analysis-of-174-cases
#18
Krisztián Katona, Nelli Farkas, Gábor Sütő, Tamás Tornóczky
Fatty infiltration in minor salivary gland biopsies and its correlation to systemic autoimmune diseases are controversial in the literature. Presence and extent of fatty infiltration in minor salivary glands of 107 Sjögren's syndrome patients and 67 age-matched sicca controls were compared with statistical analyses. No significant difference was found regarding the presence or the extent of fatty infiltration between the two groups. Fatty infiltration seems to be unrelated to Sjögren's syndrome thus its examination in salivary gland biopsy samples cannot improve the diagnostic accuracy of the disease...
April 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28425227/primary-sj%C3%A3-gren-s-syndrome-in-patients-with-celiac-disease
#19
Funda Erbasan, Deniz Turgut Çoban, Uğur Karasu, Yeşim Çekin, Bayram Yeşil, Ayhan Hilmi Çekin, Dinç Süren, Mustafa Ender Terzioğlu
BACKGROUND/AIM: Many autoimmune diseases occur concomitantly with celiac disease (CD). We aimed to determine the frequency of Sjögren's syndrome (SS) in CD patients based on SS-specific serology verified by minor labial salivary biopsy. MATERIALS AND METHODS: Eight-two patients with CD were included in the study. After examination for objective evidence of sicca complex, all patients were tested for serological presence of rheumatoid factor (RF) and antinuclear antibodies (ANAs) and for ANA profile...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424097/unusual-course-of-generalized-lymph-node-primary-plasmacytoma-in-a-patient-with-sj%C3%A3-gren-s-syndrome-a-case-report
#20
Vadim R Gorodetskiy, Natalya A Probatova, Vladimir I Vasilyev
BACKGROUND: Primary lymph node plasmacytoma is a rare disease that typically involves lymph nodes of the neck. In only 15% of cases is the disease generalized. Here, we present a case of generalized lymph node plasmacytoma in a patient with Sjögren's syndrome with an unusual course. CASE PRESENTATION: A 48-year-old white woman presented to our hospital with enlargement of groups of lymph nodes, liver, and spleen. Her medical history was consistent with a 12-year course of Sjögren's syndrome...
April 20, 2017: Journal of Medical Case Reports
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