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Sjogren's syndrome;biopsy

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https://www.readbyqxmd.com/read/28339625/cystatin-s-a-candidate-biomarker-for-severity-of-submandibular-gland-involvement-in-sj%C3%A3-gren-s-syndrome
#1
Daniela Martini, Alessia Gallo, Serena Vella, Francesca Sernissi, Antonella Cecchettini, Nicoletta Luciano, Enza Polizzi, Pier Giulio Conaldi, Marta Mosca, Chiara Baldini
Objectives.: Salivary cystatin S is a defence protein mainly produced by submandibular glands and involved in innate oral immunity. This study aimed to verify whether cystatin S was diversely expressed in different disease subsets of primary Sjogren's syndrome (pSS) patients, defined on the basis of salivary flow [unstimulated salivary flow rate (USFR)], minor salivary gland (MSG) focus score and submandibular gland ultrasonography abnormalities. We also evaluated miR-126 and miR-335-5p expression in MSG biopsies to verify whether an aberrant regulation of cystatin S at the glandular level may influence its salivary expression...
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28321568/gastrointestinal-and-liver-lesions-in-primary-childhood-sj%C3%A3-gren-syndrome
#2
Yasuyo Kashiwagi, Tatsuro Hatsushika, Norito Tsutsumi, Soken Go, Shigeo Nishimata, Hisashi Kawashima
Sjögren syndrome (SS) is characterized by lymphocytic infiltration of exocrine glands, mainly the lacrimal and salivary glands, leading to keratoconjunctivitis sicca and xerostomia. SS is one of the most common autoimmune rheumatic diseases in adults; however, few cases of primary childhood SS with gastrointestinal and liver lesions have been reported in the literature. We report five cases of primary childhood SS with gastrointestinal and liver lesions. Multiple gastric biopsies in four cases revealed atrophic gastritis in the antrum of the stomach or chronic gastritis...
March 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28288723/clinical-features-and-management-of-non-gastrointestinal-non-ocular-extranodal-mucosa-associated-lymphoid-tissue-enmalt-marginal-zone-lymphomas
#3
REVIEW
Estella Matutes, Carlos Montalban
Extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas may arise at any site of the body. The most frequent localizations other than gastrointestinal and eye are salivary gland, skin, lung and thyroid. These lymphomas usually arise in a setting of inflammation due to a persistent infection or autoimmune diseases such as Sjogren syndrome in salivary MALT lymphomas and Hashimoto's thryroiditis in thyroid lymphomas. They affect middle-aged patients with a female predominance when lymphoma arises in certain locations...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28284773/extranodal-marginal-zone-b-cell-lymphoma-an-unexpected-complication-in-children-with-sj%C3%A3-gren-s-syndrome
#4
Paz Collado, Aml Kelada, Maria Cámara, Andrew Zeft, Aron Flagg
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by the infiltration of lymphocytes into exocrine glands, resulting in the typical sicca symptoms. Unlike adults, primary SS is a very rare condition in childhood, and the risk of malignancy in juvenile SS (JSS) has not been defined. We report the detection of extranodal marginal zone B-cell lymphoma (EMZL) occurring in two children with SS. Fine needle aspiration of the salivary glands (SG) showed nonspecific findings that led to delayed diagnosis of SS...
March 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28283891/the-potential-role-for-early-biomarker-testing-as-part-of-a-modern-multidisciplinary-approach-to-sj%C3%A3-gren-s-syndrome-diagnosis
#5
REVIEW
Kenneth A Beckman, Jodi Luchs, Mark S Milner, Julian L Ambrus
Sjögren's syndrome (SS) is a chronic and progressive multisystem autoimmune disease typically managed by rheumatologists. Diagnostic delays are common, due in large part to the non-specific and variable nature of SS symptoms and the slow progression of disease. The hallmark characteristics of SS are dry eye and dry mouth, but there are a broad range of other possible symptoms such as joint and muscle pain, skin rashes, chronic dry cough, vaginal dryness, extremity numbness or tingling, and disabling fatigue...
March 10, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28272192/optic-neuropathy-associated-with-primary-sj%C3%A3-gren-s-syndrome-a-case-series
#6
Eunoo Bak, Hee Kyung Yang, Jeong-Min Hwang
PURPOSE: To determine the diverse clinical features of optic neuropathy associated with primary Sjögren's syndrome in Korean patients. METHODS: Five women with acute and/or chronic optic neuropathy who were diagnosed as primary Sjögren's syndrome were retrospectively evaluated. Primary Sjögren's syndrome was diagnosed by signs and symptoms of keratoconjunctivitis sicca, positive serum anti-Ro/SSA and/or anti-La/SSB antibodies, and/or minor salivary gland biopsy...
March 7, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28255922/the-clinical-and-pathological-characteristics-of-nephropathies-in-connective-tissue-diseases-in-the-japan-renal-biopsy-registry-j-rbr
#7
Kazunobu Ichikawa, Tsuneo Konta, Hiroshi Sato, Yoshihiko Ueda, Hitoshi Yokoyama
BACKGROUND: In connective tissue diseases, a wide variety of glomerular, tubulointerstitial, and vascular lesions of the kidney are observed. Nonetheless, recent information is limited regarding renal lesions in connective tissue diseases, except in systemic lupus erythematosus (SLE). METHODS: In this study, we used a nationwide database of biopsy-confirmed renal diseases in Japan (J-RBR) (UMIN000000618). In total, 20,523 registered patients underwent biopsy between 2007 and 2013; from 110 patients with connective tissue diseases except SLE, we extracted data regarding the clinico-pathological characteristics of the renal biopsy...
March 2, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28254788/standardisation-of-labial-salivary-gland-biopsies-in-sjogren-s-syndrome-importance-for-the-practicing-rheumatologist
#8
EDITORIAL
Robert I Fox
No abstract text is available yet for this article.
March 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28182102/a-case-report-of-nonvasculitic-autoimmune-inflammatory-meningoencephalitis-with-sensory-ganglionopathy-a-rare-presentation-of-sj%C3%A3-gren-syndrome
#9
João Peres, Simão Cruz, Rita Oliveira, Luís Santos, Ana Valverde
A 68-year-old Caucasian female was admitted to the emergency department with a progressive history of behavioural symptoms and anxiety followed by visual and auditory hallucinations, forgetfulness, and impaired gait in the previous 3 months. On examination she was psychotic and had a postural and rest tremor of the upper limbs, cogwheel rigidity of the four limbs, retropulsion on standing position, and inability to walk. During the following 2 weeks she developed xerostomia and unilateral parotiditis that improved with steroids...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28148578/hypokalaemia-in-sj%C3%A3-gren-s-syndrome-the-missing-piece
#10
Umer Farooq Khan, Lee Chun Tsu, Kong-Bing Tan, Jingxiang Huang, Audrey LiAnn Wong
A 58-year-old Chinese woman with well controlled type 1 diabetes mellitus presented with acute and progressive bilateral lower limb weakness. Investigations revealed severe hypokalaemia (1.3 mmol/L) and hypophosphataemia (<0.32 mmol/L) with rhabdomyolysis and electrocardiogram changes, without other concurrent biochemical abnormalities. Immediate intravenous and oral potassium and phosphate replacement was initiated with objective improvement in weakness with replenished electrolyte levels. Urine studies confirmed renal potassium wasting...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28133484/polyneuropathy-as-novel-initial-manifestation-in-a-case-of-nonsecretory-poems-syndrome-with-sj%C3%A3-gren-s-syndrome
#11
Minrui Liang, Zhixing Jiang, Zhiguang Lin, Bobin Chen, Hejian Zou, Weiguo Wan, Jun Liu
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome driven by plasma cell dyscrasias. We report a patient with novel initial manifestation of polyneuropathy, which was considered due to Sjögren's syndrome but with poor response to methylprednisolone (120 mg/d) and intravenous immunoglobulin (IVIg). Further investigation by imaging tests and following biopsy eventually confirmed the diagnosis of POEMS syndrome secondary to solitary plasmocytoma...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28100575/atrophic-pityriasis-versicolor-occurring-in-a-patient-with-sj%C3%A3-gren-s-syndrome
#12
Elena Marinello, Stefano Piaserico, Mauro Alaibac
Pityriasis versicolor is one of the most frequent epidermal mycotic infections in the world, but its atrophic variant is rarely described. The aetiology of the atrophy is still unknown, and two main hypotheses have been formulated, one suggesting a correlation with long-term use of topical steroids and the other a delayed type hypersensitivity to epicutaneous antigens derived from components of the fungus. Atrophic pityriasis versicolor is a benign disease, but needs to be distinguished from other more severe skin diseases manifesting with cutaneous atrophy...
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/27998024/prevalence-of-primary-sj%C3%A3-gren-s-syndrome-in-a-population-based-cohort-in-the-united-states
#13
Gabriel Maciel, Cynthia S Crowson, Eric L Matteson, Divi Cornec
Objective To report the point prevalence of primary Sjögren's syndrome (pSS) in the first population-based study performed in the United States. Methods Cases of all potential pSS patients living in Olmsted County, Minnesota on January 1, 2015 were retrieved using the Rochester Epidemiology Project resources, and ascertained by manual medical record review. pSS cases were defined according to physician diagnosis. The use of diagnostic tests was assessed and the performance of classification criteria was evaluated...
December 20, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27988437/sj%C3%A3-gren-s-syndrome-associated-myositis-with-germinal-centre-like-structures
#14
REVIEW
Alexandra Espitia-Thibault, Agathe Masseau, Antoine Néel, Olivier Espitia, Claire Toquet, Jean-Marie Mussini, Mohamed Hamidou
OBJECTIVE: Muscular impairment is a rare systemic manifestation of SS that is rarely described in the literature and classically non-specific, both clinically and histologically. We reviewed the cases of 4 patients with primary SS presenting with myositis and a common histologic pattern on muscular biopsy with germinal centre-like structures resembling that which occurs in salivary glands. METHODS: We analysed the data files of patients with SS who had muscular manifestations and underwent a muscular biopsy...
February 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27987517/-cerebral-infarction-in-a-patient-with-primary-sjogren-s-syndrome-a-case-report-and-literature-review
#15
D Yang, L Qiao, L D Zhao
Sjogren's syndrome (SS) is a chronic autoimmune disorder characterized by lymphocytes infiltration in the exocrine glands. Central nervous system complications of primary SS are not rare, but ischemic stroke has been rarely reported. Here we report a 43-year-old female with a two-year history of primary SS, presenting with sudden cerebral infarction. Her primary SS was diagnosed on the basis of clinical features, high levels of serum anti-SSA and anti-SSB antibodies, salivary gland secretion evaluation and positive sublingual gland biopsy results...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27987516/-non-hodgkin-s-lymphoma-mimicking-mikulicz-disease-a-case-report
#16
A C Liu, Y Chen, J S Jia, S Y Gao, Y Y Liu
IgG4-related disease is a systemic disorder involving a spectrum of multiple indications, and various histopathological features are shared among different IgG4-related disease subtypes, which challenge diagnosis, although certain syndromes have organ-specific involvement. Among them, Mikulicz's disease affecting the salivary and lacrimal glands, distinguished by often elevated levels of serum IgG4, infiltration of IgG4(+) plasma cells into target tissues, and diffuse swelling, mass formation, or fibrosis of affected organs...
December 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27982024/epstein-barr-virus-positive-follicular-lymphoma
#17
Nicholas Mackrides, German Campuzano-Zuluaga, Yvan Maque-Acosta, Adrienne Moul, Nouf Hijazi, Francis Offiong Ikpatt, Ronald Levy, Ramiro E Verdun, Kranthi Kunkalla, Yasodha Natkunam, Izidore S Lossos, Francisco Vega, Jennifer Chapman
Epstein-Barr virus (EBV) -associated follicular lymphoma is only rarely reported. Herein, we report the largest series analyzing prevalence and clinicopathologic characteristics of EBV-associated follicular lymphoma occurring in unselected cases. Out of 382 analyzed cases, 10 EBV-positive follicular lymphomas were identified (prevalence=2.6%, 95% confidence interval 1.3-4.0%). All EBV-positive follicular lymphomas showed EBV-encoded small RNA-positive lymphoma cells present in a follicular distribution. Of these, eight also had tissue available for testing of expression of latent membrane protein 1 (LMP1), out of which six (75%) were positive...
December 16, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27965259/standardisation-of-labial-salivary-gland-histopathology-in-clinical-trials-in-primary-sj%C3%A3-gren-s-syndrome
#18
Benjamin A Fisher, Roland Jonsson, Troy Daniels, Michele Bombardieri, Rachel M Brown, Peter Morgan, Stefano Bombardieri, Wan-Fai Ng, Athanasios G Tzioufas, Claudio Vitali, Pepe Shirlaw, Erlin Haacke, Sebastian Costa, Hendrika Bootsma, Valerie Devauchelle-Pensec, Timothy R Radstake, Xavier Mariette, Andrea Richards, Rebecca Stack, Simon J Bowman, Francesca Barone
Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27941210/-contemporary-diagnostics-of-the-primary-sj%C3%A3-gren-s-syndrome
#19
Jolanta Parada-Turska
Primary Sjögren's syndrome is one of the most common systemic autoimmune disorders, whose diagnosis is very often delayed. In most cases it is a mild disease with symptoms such as dryness and musculoskeletal pain and fatigue but 20-40% of patients suffer from severe systemic manifestations. Extraglandular manifestations can be the first sign of the disease, therefore it is very important to diagnose them as early as possible. Classification criteria established by the American-European Consensus Group (AECG) have been applied in primary Sjögren's syndrome diagnosis since 2002...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27940588/a-multicentre-study-of-95-biopsy-proven-cases-of-renal-disease-in-primary-sj%C3%A3-gren-s-syndrome
#20
Magali Jasiek, Alexandre Karras, Véronique Le Guern, Evguenia Krastinova, Rafik Mesbah, Stanislas Faguer, Noémie Jourde-Chiche, Anne-Laure Fauchais, Laurent Chiche, Emmanuelle Dernis, Guillaume Moulis, Jean-Baptiste Fraison, Estibaliz Lazaro, Perrine Jullien, Eric Hachulla, Alain Le Quellec, Philippe Rémy, Aurélie Hummel, Nathalie Costedoat-Chalumeau, Pierre Ronco, Philippe Vanhille, Vannary Meas-Yedid, Carole Cordonnier, Sophie Ferlicot, Laurent Daniel, Raphaele Seror, Xavier Mariette, Eric Thervet, Hélène François, Benjamin Terrier
OBJECTIVE: Renal involvement is a rare event during primary SS (pSS). We aimed to describe the clinico-biological and histopathological characteristics of pSS-related nephropathy and its response to treatment. METHODS: We conducted a French nationwide, retrospective, multicentre study including pSS patients fulfilling American-European Consensus Group criteria or enlarged American-European Consensus Group criteria, and with biopsy-proven renal involvement. RESULTS: A total of 95 patients were included (median age 49 years)...
December 10, 2016: Rheumatology
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