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https://www.readbyqxmd.com/read/28326724/-research-progress-on-bisphosphonate-related-osteonecrosis-of-the-jaws
#1
Pan Jian, Wang Qizhang, Liu Jiyuan
Bisphosphonates (BPs), as potent drugs inhibiting bone resorption, have been widely used for treatment of several diseases. In recent years, dentists and oral and maxillofacial surgeons reported continuously increasing cases of bisphosphonate-related osteonecrosis of the jaws (BRONJ). This disease is clinically characterized by exposed bones, formation of sequestrum, pain, and halitosis. Provided that pathogenesis of BRONJ is unclear, effective treatments for this disease are currently unavailable. Thus, prevention plays an important role in the management of BRONJ...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317352/-clinical-analysis-of-bisphosphonate-related-osteonecrosis-of-the-jaw
#2
Gong Jiaxing, Wang Huiming
OBJECTIVE: The study aims to analyze patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ). METHODS: Twelve patients treated in the Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Me-dical School, Zhejiang University from May 2013 to September 2015 were included. Patients' basic situation, medication, clinical symptoms, therapies, and effects were obtained and analyzed. RESULTS: The treatment of nine patients focused on the mandible, whereas that of three patients was on the maxilla...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28286679/a-case-of-bisphosphonate-related-osteonecrosis-of-the-jaw-in-a-patient-with-subpontic-osseous-hyperplasia
#3
Chiaki Tsuji, Hiroshi Watanabe, Hidenori Nakayama, Mitsuo Goto, Kenichi Kurita
Subpontic osseous hyperplasia (SOH) is a growth of bone occurring on the edentulous ridge beneath the pontics of fixed partial dentures (FPDs). This report describes a case of bisphosphonate- (BP-) related osteonecrosis of the jaw (BRONJ) in a SOH patient followed by deciduation of the bony lesion. A 73-year-old woman visited a dental clinic after experiencing pain and swelling beneath the pontics of a FPD that had been inserted 15 years ago. The pontics were removed, but the symptoms persisted and she was referred to our hospital...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28280705/relationship-between-disease-stage-and-renal-function-in-bisphosphonate-related-osteonecrosis-of-the-jaw
#4
Yun-Ho Kim, Han-Kyul Park, Na-Rae Choi, Seong-Won Kim, Gyoo-Cheon Kim, Dae-Seok Hwang, Yong-Deok Kim, Sang-Hun Shin, Uk-Kyu Kim
OBJECTIVES: Bisphosphonate is the primary cause of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Bisphosphonates are eliminated from the human body by the kidneys. It is anticipated that bisphosphonate levels in the body will increase if the kidney is in a weak state or if there is systemic disease that affects kidney function. The aim of this study was to analyze the relevance of renal function in the severity of BRONJ. MATERIALS AND METHODS: Ninety-three patients diagnosed with BRONJ in Pusan National University Dental Hospital from January 2012 to December 2014 were included in this study...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28256491/radiographic-findings-of-bisphosphonate-related-osteonecrosis-of-the-jaws-comparison-with-cone-beam-computed-tomography-and-panoramic-radiography
#5
A Demir, F N Pekiner
OBJECTIVE: The aim of this study is to assess radiographic findings of bisphosphonate-related osteonecrosis of the jaws (BRONJ) and to evaluate the efficiency of cone-beam computed tomography (CBCT) and panoramic radiography (PR) by comparing with each other. MATERIALS AND METHODS: The data of 46 patients treated with bisphosphonates for at least 1 to 10 years were retrospectively examined. 27 patients were selected for study group. The first inclusion criteria was an available CBCT or PR...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28210453/surgical-treatment-vs-conservative-treatment-in-intravenous-bisphosphonate-related-osteonecrosis-of-the-jaws-systematic-review
#6
REVIEW
Aida Comas-Calonge, Rui Figueiredo, Cosme Gay-Escoda
AIMS: To determine the success rates of the surgical and non-surgical treatments in the management of bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIAL AND METHODS: A systematic review of the literature was made. A PubMed Medline database search was performed in order to include clinical studies published in English,between2004 and 2014 with the following key-words: "BRONJ AND treatment" and "NOT osteoporosis". The following data was gathered: authors, title, year of publication, aim of study, level of evidence, sample size, treatment performed, treatment outcomes and follow-up...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28199140/role-of-bone-marrow-stromal-cells-in-impaired-bone-repair-from-bronj-osseous-lesions
#7
L H He, E Xiao, J G An, Y He, S Chen, L Zhao, T Zhang, Y Zhang
Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed significant challenges to maxillofacial surgeons because of the poor repair of BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone marrow stromal cells (BMSCs) play key roles during bone repair and bone regeneration. However, the activities of BMSCs derived from BRONJ lesions and the BRONJ lesion boundary, as well as the roles of BMSCs in BRONJ defect repair, are poorly defined. In this study, we found that BMSCs from the central area of the osteonecrotic BRONJ region (center-BRONJ BMSCs) and the peripheral area at the recommended debridement boundary (peri-BRONJ BMSCs) had decreased proliferative ability, self-renewal capacity, and multidifferentiation capacities compared with control BMSCs...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28186845/image-findings-of-bisphosphonate-related-osteonecrosis-of-jaws-comparing-with-osteoradionecrosis
#8
Kenichi Obinata, Shinichi Shirai, Hitoshi Ito, Motoyasu Nakamura, Marco Carrozzo, Iain Macleod, Andrew Carr, Yutaka Yamazaki, Kanchu Tei
OBJECTIVES: The aim of this study was to evaluate image characteristics of bisphosphonate related osteonecrosis of the jaws (BRONJ) and compare these with osteoradionecrosis (ORN). METHODS: Thirty-four patients with BRONJ and 16 patients with ORN were included in this study. We investigated the computed tomography (CT) and Dental Panoramic Radiograph (DPR) images for osteolysis, osteosclerosis, sequesteration, periosteal reaction, pathological fracture, and spread of soft tissue inflammation around the jaws...
February 10, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28160593/dental-extraction-following-zoledronate-induces-osteonecrosis-in-rat-s-jaw
#9
X Vidal-Gutiérrez, J-F Gómez-Clavel, L-A Gaitán-Cepeda
BACKGROUND: Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is clinically characterized by the presence of exposed bone in the oral cavity that persists for more than eight weeks. Previous attempts to establish an animal model have not sufficiently considered disease features. Our aim was to establish an inexpensive and replicable animal model that develops BRONJ in a short time. MATERIAL AND METHODS: Thirty-two male Wistar rats were randomly divided into two groups: control and experimental...
March 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28139685/skeletal-site-specific-effects-of-zoledronate-on-in-vivo-bone-remodeling-and-in-vitro-bmscs-osteogenic-activity
#10
Xue Gong, Wanlu Yu, Hang Zhao, Jiansheng Su, Qing Sheng
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been associated with long-term oral or intravenous administration of nitrogen-containing bisphosphonates (BPs). However, the pathogenesis of BRONJ remains unknown, and definitively effective treatment has not yet been established. Bisphosphonate-related osteonecrosis (BRON) tends to occur in maxillofacial bones. Why this occurs is still unclear. Here we show that zoledronate (Zol) treatment suppresses alveolar bone remodeling after tooth typical clinical and radiographic hallmarks of the human BRONJ, whereas enhances peripheral bone quantity in bone remodeling following injury in the same individuals, shown as increased cortical bone thickness, increased trabecular bone formation and accelerated bone defect repair...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28107028/interrelationship-of-clinical-radiographic-and-haematological-features-in-patients-under-bisphosphonate-therapy
#11
Valesca S Koth, Maria A Figueiredo, Fernanda G Salum, Karen Cherubini
OBJECTIVES: To analyze the clinical, radiographic and haematological aspects of patients under bisphosphonate therapy. METHODS: A retrospective study was conducted where the records of patients taking bisphosphonates were analyzed considering the occurrence of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Evaluation included panoramic and periapical radiographies, haematological examinations and clinical features. Radiographies were analyzed determining the presence or absence of bone sclerosis, osteolysis, persisting alveolar socket, narrowing of the mandibular canal, widening of the periodontal ligament space, periradicular radiolucency, sequestrum and thickening of the lamina dura...
February 17, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28061356/clinical-differences-in-autofluorescence-between-viable-and-nonvital-bone-a-case-report-with-histopathologic-evaluation-performed-on-medication-related-osteonecrosis-of-the-jaws
#12
Ilaria Giovannacci, Marco Meleti, Domenico Corradi, Paolo Vescovi
Medication-related osteonecrosis of the jaws (MRONJ) is an adverse side effect of several drug therapies, including bisphosphonates (BPs). Osteonecrosis of the jaw specifically related to BP therapy is usually referred to using the acronym BRONJ. However, no consensus has yet been reached regarding the most appropriate management of BRONJ. The greatest success rates have been recorded with surgical removal of necrotic bone. In particular, erbium:yttrium-aluminum-garnet (Er:YAG) laser-assisted surgery has shown significantly better results than conventional surgical approaches...
December 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28039736/extensive-surgical-procedures-result-in-better-treatment-outcomes-for-bisphosphonate-related-osteonecrosis-of-the-jaw-in-patients-with-osteoporosis
#13
Hui Young Kim, Shin-Jae Lee, Soung Min Kim, Hoon Myoung, Soon Jung Hwang, Jin-Young Choi, Jong-Ho Lee, Pill-Hoon Choung, Myung Jin Kim, Byoung Moo Seo
PURPOSE: To identify the risk factors associated with relapse or treatment failure after surgery for bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients with osteoporosis. PATIENTS AND METHODS: We performed a retrospective cohort study of BRONJ in patients with osteoporosis who had undergone surgical procedures from 2004 to 2016 at the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. The predictor variables were a set of heterogeneous variables, including demographic (age, gender), anatomic (maxilla or mandible, or both, affected location), clinical (disease stage, etiology, comorbidities, history of intravenous bisphosphonate intake), time (conservative treatment before surgery, bisphosphonate treatment before the development of BRONJ, discontinuation of the drug before surgery, interval to final follow-up, interval to reoperation in the case of relapse or treatment failure), and perioperative variables (type of anesthesia, type of surgical procedures)...
December 15, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28035494/antiresorptive-agent-related-osteonecrosis-of-the-jaw-position-paper-2017-of-the-japanese-allied-committee-on-osteonecrosis-of-the-jaw
#14
REVIEW
Toshiyuki Yoneda, Hiroshi Hagino, Toshitsugu Sugimoto, Hiroaki Ohta, Shunji Takahashi, Satoshi Soen, Akira Taguchi, Toshihiko Nagata, Masahiro Urade, Takahiko Shibahara, Satoru Toyosawa
Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is an intractable, though rare, complication in cancer patients with bone metastases and patients with osteoporosis who are treated with antiresorptive agents, including bisphosphonates and denosumab. Despite the more than 10 years that have passed since the first cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were reported, our understanding of the epidemiology and pathophysiology of ARONJ remains limited, and data supported by evidence-based medicine are still sparse...
January 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27989705/histochemical-observation-of-bony-reversal-lines-in-bisphosphonate-related-osteonecrosis-of-the-jaw
#15
Soung Min Kim, Mi Young Eo, Yeon Sook Kim, Suk Keun Lee
OBJECTIVE: To contrast the pattern of bony reversal linesin bisphosphonate osteonecrosis of the jaw with infected osteomyelitis derived acute osteonecrosis of the jaw. STUDY DESIGN: This study investigated the histochemical characteristics of reversal lines in 50 cases of BP-related osteonecrosis of the jaw (BRONJ) compared with non-BP-involved bones in 20 cases of chronic osteomyelitis of the jaws. Necrotic bones were stained by using the toluidine blue, Safranin O, Giemsa, van Gieson, and Masson's trichrome staining methods...
February 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27924611/quantitative-real-time-gene-profiling-of-human-alveolar-osteoblasts
#16
Dawn E Coates, Sobia Zafar, Trudy J Milne
The use of quantitative real-time reverse transcriptase PCR (qRT(2)-PCR) for the identification of differentially regulated genes is a powerful technology. The protocol presented here uses qRT(2)-PCR gene arrays to investigate the regulation of 84 angiogenic related genes in human primary alveolar osteoblasts following treatment with the bisphosphonate, zoledronic acid (ZA), and geranylgeraniol (GGOH). GGOH has potential as a therapeutic agent for Bisphosphate-Related Osteonecrosis of the Jaw (BRONJ), a serious side-effect resulting from the treatment for metastatic cancer (Zafar et al...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27919595/the-starting-point-for-bisphosphonate-related-osteonecrosis-of-the-jaw-alveolar-bone-or-oral-mucosa-a-randomized-controlled-experimental-study
#17
Mohammad Zandi, Arash Dehghan, Pejman Janbaz, Hamid Malekzadeh, Payam Amini
OBJECTIVE: Although over a decade has passed since first introduction of BRONJ, the exact pathophysiology of this disease is still unclear. The present experimental study aimed to determine whether the oral mucosa or alveolar bone serves as the starting point for BRONJ development. SUBJECTS AND METHODS: Sixty male Wistar rats were randomly assigned into study and control groups (each, n = 30), and received intraperitoneal injection of 0.06 mg/kg zoledronate and saline, respectively, once a week for 12 weeks...
January 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27876532/efficacy-of-the-c-terminal-telopeptide-test-in-predicting-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaw-a-systematic-review
#18
REVIEW
K J Dal Prá, C A A Lemos, R Okamoto, A M P Soubhia, E P Pellizzer
This systematic review evaluated the efficacy of the morning fasting serum C-terminal telopeptide (CTX) test in predicting the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ). A comprehensive search of studies published up to March 2016, and listed in the PubMed/MEDLINE, Web of Science, and Cochrane Library databases, was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This review has been registered in the PROSPERO international prospective register of systematic reviews (CRD42016036717)...
February 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27847735/diseases-having-an-influence-on-inhibition-of-angiogenesis-as-risk-factors-of-osteonecrosis-of-the-jaw
#19
Seung Jae Paek, Won-Jong Park, Ho-Sung Shin, Moon-Gi Choi, Kyung-Hwan Kwon, Eun Joo Choi
OBJECTIVES: The objective of this study was to retrospectively investigate the association of diseases having an influence on inhibition of angiogenesis such as hypertension, diabetes mellitus type II, hypercholesterolemia, and rheumatoid arthritis (RA) with the development of osteonecrosis of the jaws. MATERIALS AND METHODS: The 135 patients were allocated into 4 groups of bisphosphonate-related osteonecrosis of the jaw (BRONJ) group (1A); non-BRONJ group (1B); osteonecrosis of the jaw (ONJ) group (2A); and control group (2B), according to histologic results and use of bisphosphonate...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27736017/uncertainty-of-current-algorithm-for-bisphosphonate-related-osteonecrosis-of-the-jaw-in-population-based-studies-a-systematic-review
#20
Hye-Yeon Kim, Jin-Woo Kim, Sun-Jong Kim, Sang-Hwa Lee, Hong-Soo Lee
To assess the relevance of previous epidemiologic studies on bisphosphonate-related osteonecrosis of the jaw (BRONJ), we first conducted a systematic review of large population-based observational studies and evaluated the validity of claims-based algorithms for the identification of BRONJ. Studies containing primary observational epidemiologic data regarding bisphosphonate (BP) exposure and outcomes of osteonecrosis of the jaw were systematically reviewed. Using surrogates for identifying potential BRONJ cases from a population-based hospital registry, validation was performed through medical chart review...
October 13, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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