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https://www.readbyqxmd.com/read/29236901/collagen-sponge-and-rhbmp-2-improve-socket-healing-in-rats-treated-with-zoledronic-acid
#1
Ji-Su Oh, Su-Gwan Kim
The aim of the present study was to evaluate the possible use of a commercial absorbed collagen sponge and bone morphogenetic protein (BMP) for the prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in rats. Twenty rats received intraperitoneal injections of 0.1-mg/kg of zoledronic acid three times a week for eight weeks before the extraction of both maxillary first molars after eight weeks. A collagen sponge (experimental group 1) and a collagen sponge with recombinant human BMP-2 (experimental group 2) were applied to the right extraction sockets of ten rats each...
December 7, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29233701/in%C3%A2-vivo-effects-of-geranylgeraniol-on-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaws
#2
Filip Koneski, Danica Popovic-Monevska, Icko Gjorgoski, Jovanka Krajoska, Mirjana Popovska, Ilijana Muratovska, Boris Velickovski, Gordana Petrushevska, Vladimir Popovski
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a complication of the bisphosphonate (BP) treatment and its pathopysiology is still not fully understood. The existing preventive and treatment options require updates and more attention. Geranylgeraniol (GGOH) so far demonstrated an increased activity and viability of the cells previously treated with zoledronic acid (ZA). The aim of this study was to evaluate the in vivo effects of GGOH on the development of BRONJ...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29155533/conservative-prosthetic-rehabilitation-of-medication-related-osteonecrosis-of-the-jaw-mronj
#3
Alexandra Johanna Leven, Antony J Preston
Osteonecrosis of the jaw associated with bisphosphonates and other medications is a growing problem facing dentists. It can have a significant and debilitating impact upon patients. Various treatment options ranging from surgical intervention to management with antibiotics and analgesics have been proposed. This article presents one method of conservative treatment and prosthetic rehabilitation in a patient with ongoing BRONJ of the maxilla unsuitable for surgical management. Clinical relevance: Dentists need to be able to identify patients who are at risk of developing BRONJ and have an awareness of the appropriate management as well as potential oral rehabilitation options for these patients...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29130610/the-effects-of-icariin-on-wound-healing-of-extraction-sites-with-administration-of-zoledronic-and-dexamethasone-a-rat-model-study
#4
Jie Liu, Nikos Mattheos, Cheng Su, Chuanxi Deng, Nanyu Luo, Zekun Wang, Hua Tang
OBJECTIVE: This study was intended to investigate the effects of Icariin on the healing of tooth extraction sites under systemic administration of Zoledronic and Dexamethasone. METHOD: Thirty female rats underwent bilateral ovariectomy and were randomly assigned to 5 groups: SS group received weekly injection of saline while ZD, ZD+LICA, ZD+MICA and ZD+HICA groups received Zoledronic with Dexamethasone for 8 weeks. One week later, mandibular first molars were extracted in all groups...
November 11, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29109842/submental-perforator-flap-for-soft-tissue-reconstruction-in-bisphosphonate-related-osteonecrosis-of-the-jaws
#5
Jose-Antonio García-de Marcos, Juan Rey-Biel
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) has emerged as an important and increasingly common comorbidity, especially in patients undergoing long-term treatment with high doses of bisphosphonates. The management of BRONJ remains controversial. Surgical treatment is necessary in severe cases. Treatment of the bone requires sequestrectomy or resection. Given the lack of sufficient mucosa to perform the operation and fragility of margins in many patients, local flaps are crucial. We report two cases of stage-3 BRONJ presenting secondary infection with Actinomyces , receiving treatment consisting of marginal resection of the necrotic bone, reinforcement with a reconstruction plate, and reconstruction of soft tissues using a submental perforator artery flap ipsilateral to the lesion...
December 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28965092/attitudes-and-perceptions-of-gps-and-community-pharmacists-towards-their-role-in-the-prevention-of-bisphosphonate-related-osteonecrosis-of-the-jaw-a-qualitative-study-in-the-north-east-of-england
#6
Andrew Sturrock, Philip M Preshaw, Catherine Hayes, Scott Wilkes
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare, yet significant, adverse effect of bisphosphonate therapy. A multidisciplinary approach to the prevention of BRONJ is recommended due to the significant morbidity and difficulty treating the condition. Current evidence suggests that both general practitioners (GPs) and community pharmacists have limited knowledge relating to BRONJ and that preventative strategies are rarely implemented. OBJECTIVE: To explore the attitudes and perceptions of GPs and community pharmacists on the risks and preventative strategies for the development of BRONJ...
September 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28958140/platelet-rich-fibrin-in-the-management-of-medication-related-osteonecrosis-of-the-jaw-a-clinical-and-histopathological-evaluation
#7
F Inchingolo, S Cantore, G Dipalma, I Georgakopoulos, M Almasri, E Gheno, A Motta, M Marrelli, D Farronato, A Ballini, A Marzullo
Bisphosphonates are antiresorptive pharmacological agents used in the treatment of osteoporosis. Recently, osteonecrosis of the jaw has been recognized as a potential side effect in patients on long-term bisphosphonate therapy. This condition, popularly called bisphosphonate-related osteonecrosis of the jaw (BRONJ), has been rechristened as MRONJ (medication-related osteonecrosis of the jaw) to accommodate the increasing number of cases of osteonecrosis of jaws associated with various other antiresorptive and antigiogenic pharmacological therapies...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28947697/-dental-implant-treatment-in-patients-receiving-anti-resorptive-agents
#8
Shinichiro Kuroshima
Dental implant treatment is one of the most reliable therapeutic options for replacing missing teeth. In 2003, it was demonstrated that osteonecrosis of the jaw(ONJ)occurred in patients taking bisphosphonates(BRONJ). Recently, ONJ has also been demonstrated to occur in patients taking anti-receptor activator of nuclear factor-kappaB ligand antibody(denosumab:DRONJ). However, the precise mechanisms of ONJ remain unclear and definitive treatment strategies for ONJ have not been developed. There has been little information regarding the relationship between ONJ and dental implant treatment...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28902422/transplantation-of-noncultured-stromal-vascular-fraction-cells-of-adipose-tissue-ameliorates-osteonecrosis-of-the-jaw-like-lesions-in-mice
#9
Shinichiro Kuroshima, Muneteru Sasaki, Kazunori Nakajima, Saki Tamaki, Hiroki Hayano, Takashi Sawase
The precise pathoetiology and effective treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remain unknown. Transplantation of noncultured stromal vascular fraction (SVF) cells has been shown to be a useful method for regenerative medicine in place of stem cell therapy. This study investigated the effects of noncultured SVF transplantation on tooth extraction socket healing in mice. Both chemotherapeutic/bisphosphonate combination therapy for 7 weeks and tooth extraction of maxillary first molars at 3 weeks after drug administration were performed using female C57BL/6J mice...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28875143/a-case-of-bisphosphonate-related-osteonecrosis-of-the-jaw-with-a-particularly-unfavourable-course-a-case-report
#10
Massimo Viviano, Alessandra Addamo, Serena Cocca
Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death...
August 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28869827/effects-of-dexamethasone-and-nimesulide-on-bisphosphonate-related-osteonecrosis-of-the-jaw-an-experimental-study
#11
Camila Carvalho de Oliveira, Paulo Goberlânio de Barros Silva, Antonio Ernando Carlos Ferreira, Romélia Pinheiro Gonçalves, Fabrício Bitu de Sousa, Mário Rogério Lima Mota, Ana Paula Negreiros Nunes Alves
OBJECTIVE: To evaluate the effects of dexamethasone (DEX) and nimesulide (NIM) on Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in rats. DESIGN: BRONJ was induced by zoledronic acid (ZA) infusion (0.2mg/kg) in Wistar rats (n=8), followed by extraction of the left lower first molar (BRONJ groups). Control groups (n=40) received saline (IV). For eight weeks, DEX (0.04, 0.4, 4mg/kg) or saline (SAL) were administered by gavage 24h before each infusion of ZA or saline (IV), or NIM (10...
August 30, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28809382/exposed-necrotic-bone-in-183-patients-with-bisphosphonate-related-osteonecrosis-of-the-jaw-associated-clinical-characteristics
#12
L Bagan, Y Jiménez, M Leopoldo, J Murillo-Cortes, J Bagan
BACKGROUND: The main objective of our study was to identify oral symptoms and signs most likely to be associated with the exposure of necrotic bone in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: The study group consisted of 183 patients with BRONJ. We recorded data on the underlying disease, bisphosphonate used, location of osteonecrosis, symptoms, pain, fistula development, suppuration, infection, exposed necrotic bone, and BRONJ stage...
September 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28809381/serum-levels-of-rankl-and-opg-and-the-rankl-opg-ratio-in-bisphosphonate-related-osteonecrosis-of-the-jaw-are-they-useful-biomarkers-for-the-advanced-stages-of-osteonecrosis
#13
L Bagan, Y Jiménez, M Leopoldo, A Rubert, J Bagan
BACKGROUND: We determined whether serum levels of Receptor Activator for Nuclear Factor κ B Ligand (RANKL), Osteoprotegerin (OPG), and the RANKL/OPG ratio could be useful biomarkers for the severity of oral lesions in bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIAL AND METHODS: A case-control study in which Group 1 consisted of 41 patients with BRONJ due to intravenous bisphosphonates, and Group 2 consisted of 44 healthy control cases. The plasma levels of RANKL and OPG were analyzed by an ELISA assay...
September 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28781866/managing-bisphosphonate-related-osteonecrosis-of-the-jaws-with-xenografts-a-case-report
#14
Aluísio Martins de Oliveira Ruellas, Daiane Cristina Peruzzo, Marcelo Henrique Napimoga
It is possible to manage large bone destruction induced by BRONJ using xenograft grafting to promote a bone formation.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28729804/a-case-of-tooth-fracture-occurred-upon-medicating-bisphosphonate-for-an-elderly-person-preservation-therapy-and-responses-for-stage-0-of-bisphosphonate-related-osteonecrosis-of-jaw
#15
Noriko Suzuki, Hitoshi Oguchi, Yu Yamauchi, Yasuyo Karube, Yukimi Suzuki, Noriyasu Hosoya
This case report aimed to report the progress of preservation therapy and response of symptoms and signs for Stage 0 of bisphosphonate-related osteonecrosis of jaw (BRONJ). A 68-year-old female was recognized having a tooth at the left upper first molar fracture upon medicating bisphosphonate (BP) in 2007. At that time, the extraction of the tooth was an absolute contraindication. Therefore, we performed preservation therapy. We observed the symptoms and signs every month. After 5 months, swelling and redness in the entire first molar tooth were seen and fistula formed partly...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28647850/wound-healing-protein-profiles-in-the-postoperative-exudate-of-bisphosphonate-related-osteonecrosis-of-mandible
#16
Soung Min Kim, Mi Young Eo, Yun Ju Cho, Yeon Sook Kim, Suk Keun Lee
Recurrent bacterial infections in cases of bisphosphonate-related osteonecrosis of jaw (BRONJ) frequently occur. Therefore, BRONJ are usually treated by radical saucerization followed by intensive antibiotic medications without bisphosphonate therapy. The postoperative exudate (POE) from BRONJ lesions may directly indicate the inflammatory status of osteomyelitis in patients, but so far, the POE has rarely been examined for its expression of various cytokines and wound healing proteins. A total of 27 cases of BRONJ, which involved the mandible, were selected and their individual POE collected 6 h, 1 day, and 2 days after surgical intervention was analyzed by immunoprecipitation high performance liquid chromatography (IP-HPLC)...
June 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28642568/treatment-for-bisphosphonate-related-osteonecrosis-of-the-jaw
#17
COMMENT
Silvia Spivakovsky
Data sourcesCochrane Oral Health Group Trials Register, CENTRAL, Medline, Embase, CancerLit, CINAHL, AMED, clinicaltrials.gov and the WHO International Trial Registry Platform. The reviewers searched six grey literature sites and contacted authors, researchers and pharmaceutical companies.Study selectionRandomised controlled trials for the treatment of BRONJ comparing interventions with other treatment or placebo were included in any setting with no age restriction.Data extraction and synthesisIndependently, two reviewers selected studies for inclusion, risk of bias and data extraction...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28604257/genetic-factors-related-with-early-onset-of-osteonecrosis-of-the-jaw-in-patients-with-multiple-myeloma-under-zoledronic-acid-therapy
#18
Efstathios Kastritis, Pelagia Melea, Tina Bagratuni, Ioannis Melakopoulos, Maria Gavriatopoulou, Maria Roussou, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Evangelos Terpos, Meletios A Dimopoulos
Specific genetic polymorphisms (SNPs) have been correlated with the development of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in small series. We screened 140 myeloma patients (36 patients with and 104 without BRONJ) for the presence of previously identified SNPs in PPARG and CYP2C8 genes. All the patients received exclusively zolendronic acid (ZA) therapy and were followed prospectively for BRONJ. SNPs in both genes were associated with a higher risk of development of early BRONJ, occurring within less than 2 years of ZA therapy (59% vs...
June 11, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28594896/zoledronate-suppressed-angiogenesis-and-osteogenesis-by-inhibiting-osteoclasts-formation-and-secretion-of-pdgf-bb
#19
Si-Yong Gao, Guang-Sen Zheng, Lin Wang, Yu-Jie Liang, Si-En Zhang, Xiao-Mei Lao, Kan Li, Gui-Qing Liao
PURPOSE: Bisphosphonates related osteonecrosis of jaw (BRONJ) is a severe complication of systemic BPs administration, the mechanism of which is still unclarified. Recently, platelet-derived growth factor-BB (PDGF-BB) secreted by preosteoclasts was reported to promote angiogenesis and osteogenesis. This study aimed to clarify whether bisphosphonates suppressed preosteoclasts releasing PDGF-BB, and whether the suppression harmed coupling of angiogenesis and osteogenesis, which could contribute to BRONJ manifestation...
2017: PloS One
https://www.readbyqxmd.com/read/28566618/underlying-mechanisms-and-therapeutic-strategies-for-bisphosphonate-related-osteonecrosis-of-the-jaw-bronj
#20
Yasuo Endo, Hiroyuki Kumamoto, Masanori Nakamura, Shunji Sugawara, Teruko Takano-Yamamoto, Keiichi Sasaki, Tetsu Takahashi
Bisphosphonates (BPs), with a non-hydrolysable P-C-P structure, are cytotoxic analogues of pyrophosphate, bind strongly to bone, are taken into osteoclasts during bone-resorption and exhibit long-acting anti-bone-resorptive effects. Among the BPs, nitrogen-containing BPs (N-BPs) have far stronger anti-bone-resorptive effects than non-N-BPs. In addition to their pyrogenic and digestive-organ-injuring side effects, BP-related osteonecrosis of jaws (BRONJ), mostly caused by N-BPs, has been a serious concern since 2003...
2017: Biological & Pharmaceutical Bulletin
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