M Dioguardi, M Di Cosola, C Copelli, S Cantore, C Quarta, G Nitsch, D Sovereto, F Spirito, G A Caloro, A P Cazzolla, R Aiuto, E Cascardi, A Greco Lucchina, L Lo Muzio, A Ballini, F Mastrangelo
OBJECTIVE: Bisphosphonates, the most common anti-resorptive medications, are internalized by osteoclasts, where they inhibit the macrophage colony-stimulating factor (M-CSF) pathway, preventing their differentiation, inhibiting anchorage to the cell membrane, and inducing apoptosis. In patients undergoing oral bisphosphonate therapy, oral surgery involves a high risk of developing drug-related osteonecrosis of the jaws (BRONJ/MRONJ), among the possible complications. MATERIALS AND METHODS: A systematic search was carried out on the PubMed, Scopus and Cochrane Library search engines, using the keywords "oral bisphosphonates AND tooth extraction", "third molar extraction AND oral bisphosphonates"...
July 2023: European Review for Medical and Pharmacological Sciences