Fiona Rayner, Amy E Anderson, Kenneth F Baker, Christopher D Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S Goodyear, Catharien M U Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M Dawn Teare, Stephen Young, John D Isaacs
BACKGROUND: Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and pathogenesis has improved greatly over recent years, however, very little is known of the factors that trigger disease relapses (flares), converting diseases from inactive to active states. Focussing on rheumatoid arthritis (RA), the challenge that we will address is why IMIDs remit and relapse. Extrapolating from pathogenetic factors involved in disease initiation, new episodes of inflammation could be triggered by recurrent systemic immune dysregulation or locally by factors within the joint, either of which could be endorsed by overarching epigenetic factors or changes in systemic or localised metabolism...
July 19, 2021: BMC rheumatology