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Ultrasound;synovial;biopsy

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https://www.readbyqxmd.com/read/27826764/clinical-features-of-soft-tissue-sarcoma-presenting-intra-tumour-haematoma-case-series-and-review-of-the-literature
#1
Manabu Hoshi, Naoto Oebisu, Makoto Ieguchi, Yoshitaka Ban, Masatsugu Takami, Hiroaki Nakamura
INTRODUCTION: Intra-tumour haematoma is an uncommon clinical presentation in malignant soft tissue tumours. This study aimed to highlight the clinical features of patients with soft tissue sarcomas with intra-tumour haematoma. METHODS: The patient group was composed of eight men and one woman aged between 29 and 83 years (mean 44.0 ± 20.8). The average follow-up was 29.8 months. Clinical information, including clinical features, radiological information and treatment course, was retrospectively investigated...
November 8, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27761602/calcified-synovial-metastasis-in-the-knee-from-renal-cell-carcinoma-a-case-report
#2
Michael McConnell, Rajendra Kumar, Behrang Amini, Patrick P Lin, Wei-Lien Wang
We present the case of an 83-year-old man who had painful swelling of right knee for 6 months. Radiographs showed a large intra-articular soft-tissue mass with small calcifications, whereas MRI detected a multilobulated intra-articular tumor with bone erosions at the distal femur. Histopathology of ultrasound-guided biopsy specimen of the synovial mass revealed it to be a poorly differentiated metastatic carcinoma. Abdominal computed tomography with intravenous contrast medium administration found a heterogeneously enhancing large right renal mass with calcifications, which was shown to be a renal cell carcinoma on histopathology...
October 20, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27744399/success-rate-and-utility-of-ultrasound-guided-synovial-biopsies-in-clinical-practice
#3
Aurélie Najm, Carl Orr, Marie-Françoise Heymann, Géraldine Bart, Douglas J Veale, Benoît Le Goff
OBJECTIVE: The utility of synovial biopsy in increasing our understanding of the pathogenesis of inflammatory arthropathies, as well as in evaluating treatments, is well established. Ultrasound (US) allows synovial assessment and therefore assists in biopsying synovial tissue in a safe and well-tolerated manner. This study's objectives were to (1) determine the rate of success in retrieving synovial tissue using US guidance, (2) describe the indications for US-guided synovial biopsies in the clinical setting, (3) determine how frequently the synovial biopsy can lead to a clear diagnosis, and (4) assess the quality of the synovial tissue obtained using this technique...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27573797/sonography-is-superior-to-serum-based-biomarkers-for-measuring-disease-status-in-experimental-rheumatoid-arthritis
#4
Shuqiang Chen, Qing Zheng, Hui Liu, Jinshu Zeng, Zhen Ye, Yiming Su, Guorong Lv
OBJECTIVES: Progress in developing novel rational treatments for rheumatoid arthritis (RA) critically depends on preclinical work in experimental animals. However, there is lack of insight into the most appropriate mode of noninvasive measurement of disease status in experimental RA. This study compared sonography with serum biomarkers in a rabbit model of RA. METHODS: Six-month-old male New Zealand White rabbits were randomized into 2 groups: antigen-induced arthritis group (n = 25), which was subjected to ovalbumin immunization and intra-articular injection; and control group (n = 5)...
October 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27553941/ultrasound-guided-synovial-tru-cut-biopsy-indications-technique-and-outcome-in-111-cases
#5
Jacqueline C M Sitt, James F Griffith, Fernand M Lai, Mamie Hui, K H Chiu, Ryan K L Lee, Alex W H Ng, Jason Leung
OBJECTIVE: To investigate the diagnostic performance of ultrasound-guided synovial biopsy. METHODS: Clinical notes, pathology and microbiology reports, ultrasound and other imaging studies of 100 patients who underwent 111 ultrasound-guided synovial biopsies were reviewed. Biopsies were compared with the final clinical diagnosis established after synovectomy (n = 43) or clinical/imaging follow-up (n = 57) (mean 30 months). RESULTS: Other than a single vasovagal episode, no complication of synovial biopsy was encountered...
August 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27463825/ultrasound-guided-synovial-biopsy-of-the-wrist-does-not-alter-subsequent-clinical-or-ultrasound-disease-activity-assessments-a-prospective-study-for-incorporation-of-imaging-in-clinical-trials
#6
Ilias Lazarou, Stephen Kelly, Frances Humby, Maria Di Cicco, Lu Zou, Vidalba Rocher-Ros, Rebecca Eve Hands, Nora Ng, Arti Mahto, Costantino Pitzalis
OBJECTIVES: Ultrasound-guided synovial biopsy (UGSB) is a minimally-invasive procedure capable of retrieving good quality tissue from small and large joints. The use of UGSB in prospective clinical trials poses a dilemma as to whether biopsied joints may be later included in core data sets for clinical or imagining response, as the procedure itself may alter disease activity assessment. In this study, we examine the impact of UGSB of the wrist on subsequent clinical and ultrasound (US) assessments in a cohort of rheumatoid arthritis (RA) patients prior to initiation of anti-TNF-alpha therapy...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27325304/osteoid-osteoma-mimicking-monoarticular-juvenile-idiopathic-arthritis-in-a-girl
#7
Francesco Massei, Gianluigi Laccetta, Monica Barrani, Luca Fabbri, Virna Zampa, Alessandro Paolicchi, Roberto Cioni, Eugenio Mario Ciancia, Michelangelo Scaglione, Rita Consolini
Osteoid osteoma (OO) is a benign osteogenic neoplasm, usually affecting children and young adults, that is typically characterized by nocturnal pain and response to non-steroidal anti-inflammatory drugs. OO is frequently misdiagnosed because it mimics juvenile idiopathic arthritis (JIA), bone infection or malignancy. Herein we report the case of a girl who presented with chronic monoarthritis of the knee mimicking JIA. After 1 year, OO of the femoral distal metaphysis was diagnosed. OO was treated with computed tomography-guided radiofrequency ablation with disappearance of the symptoms and resolution of the neoplasm...
August 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27094362/is-there-a-role-of-synovial-biopsy-in-drug-development
#8
Maria Filkova, Andrew Cope, Tim Mant, James Galloway
Rheumatoid arthritis (RA) is an autoimmune disease which causes significant pain, joint deformity, functional disability. The pathological hallmark of RA is inflammation of the synovium characterized by involvement of inflammatory and resident stromal cells, soluble mediators and signalling pathways leading to irreversible joint destruction. The treatment goal in RA has evolved over the last decade towards a target of disease remission that is achieved in less than a third of patients in clinical trials. The lack of therapeutic response to current treatments is suggestive of alternative drivers of RA pathogenesis that might serve as promising therapeutic targets...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27036513/immunopathologic-characterization-of-ultrasound-defined-synovitis-in-rheumatoid-arthritis-patients-in-clinical-remission
#9
Julio Ramírez, Raquel Celis, Alicia Usategui, Virginia Ruiz-Esquide, Regina Faré, Andrea Cuervo, Raimon Sanmartí, José L Pablos, Juan D Cañete
BACKGROUND: Patients with rheumatoid arthritis (RA) in clinical remission may have ultrasound-defined synovitis according to the presence of power Doppler (PD) signal. The objective was to describe the immunopathologic characteristics of ultrasound-defined synovitis compared with synovitis in patients with clinically active RA. METHODS: We included between 6 and 8 ultrasound-guided synovial biopsies per patient from 20 patients with RA in clinical remission (DAS28-ESR <2...
March 31, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26809203/ultrasound-and-magnetic-resonance-imaging-assessment-of-joint-disease-in-symptomatic-patients-with-cystic-fibrosis-arthropathy
#10
G Fitch, K Williams, J E Freeston, S Dass, A Grainger, R Hodgson, L Horton, P Whitaker, D Peckham
OBJECTIVES: Cystic fibrosis arthropathy (CFA) is a term commonly used for joint pain with and without swelling seen in some patients with CF. Early studies into CFA focused on the presence of rheumatoid factor and immunological changes on synovial biopsy, with parallels drawn between respiratory and joint activity. Identification of anti-cyclic citrullinated peptide antibodies (anti-CCP) as a marker of rheumatoid arthritis (RA), along with increased access to sensitive imaging techniques including ultrasound (US) and magnetic resonance imaging (MRI), offer great potential to investigate and more accurately understand the type(s) of inflammatory arthritis that may underlie CFA...
July 2016: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/26628882/a-primary-intravascular-synovial-sarcoma-causing-deep-vein-thrombosis-and-pulmonary-embolism-in-a-20-year-old-woman
#11
M Schreiner, W Sanad, B M Pfitzner, G Baumann, F Knebel
Primary intravascular synovial sarcoma is a rare malignancy with only a few cases documented in the literature. On presentation, this tumour usually resembles a deep venous thrombosis (dvt) or pulmonary embolism (pe). Here, we report the case of a 20-year-old woman complaining of shortness of breath who had a history of dvt 6 weeks before presentation at our institution. Vascular ultrasound detected a suspicious mass in the right groin, which was identified as a monophasic synovial sarcoma by surgical biopsy...
October 2015: Current Oncology
https://www.readbyqxmd.com/read/26581578/ultrasound-guided-synovial-biopsy
#12
REVIEW
Jacqueline C M Sitt, James F Griffith, Priscilla Wong
Ultrasound-guided needle biopsy of synovium is an increasingly performed procedure with a high diagnostic yield. In this review, we discuss the normal synovium, as well as the indications, technique, tissue handling and clinical applications of ultrasound-guided synovial biopsy.
2016: British Journal of Radiology
https://www.readbyqxmd.com/read/26097225/use-of-ultrasound-guided-small-joint-biopsy-to-evaluate-the-histopathologic-response-to-rheumatoid-arthritis-therapy-recommendations-for-application-to-clinical-trials
#13
Frances Humby, Stephen Kelly, Rebecca Hands, Vidalba Rocher, Maria DiCicco, Nora Ng, Lu Zou, Serena Bugatti, Antonio Manzo, Roberto Caporali, Carlomaurizio Montecucco, Michele Bombardieri, Costantino Pitzalis
OBJECTIVE: To examine in a cohort of rheumatoid arthritis (RA) patients undergoing serial ultrasound (US)-guided biopsies of small joints in the context of clinical trials whether sufficient synovial tissue could be obtained at both baseline and second biopsy to: 1) accurately evaluate the synovial immune phenotype, 2) permit adequate RNA extraction to determine molecular signatures, and 3) sensitively detect change in the number of synovial sublining macrophages (CD68+) following effective therapy...
October 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26075135/monophasic-synovial-sarcoma-of-prostatic-fascia-case-report-and-literature-review
#14
Lucio Olivetti, Luigi Benecchi, Serena Corti, Carlo Del Boca, Matteo Ferrari, Pietro Sergio, Luisa Bercich, Giulia Tanzi
Synovial sarcoma (SS) primarily occurs in the para-articular soft tissue of the lower extremities in young adults and it is extremely rare in the prostatic region. We report a case of a 46-year-old man who presented with urinary retention. Pelvic ultrasound (US) examination, computed tomography (CT), and magnetic resonance imaging (MRI) demonstrated an 8.5 cm mass that appeared to originate in the prostatic fascia of the right lobe. Preoperative prostatic ultrasound transrectal needle biopsy revealed mesenchymal neoplastic tissue...
2015: Case Reports in Urology
https://www.readbyqxmd.com/read/26034155/evaluation-of-minimally-invasive-ultrasound-guided-synovial-biopsy-techniques-by-the-omeract-filter-determining-validation-requirements
#15
REVIEW
Frances Humby, Stephen Kelly, Serena Bugatti, Antonio Manzo, Andrew Filer, Arti Mahto, Joao Eurico Fonseca, Bernard Lauwerys, Maria-Antonietta D'Agostino, Esperanza Naredo, Rik Lories, Carlomaurizio Montecucco, Paul Peter Tak, Oliver Fitzgerald, Malcolm D Smith, Douglas J Veale, Ernest H Choy, Vibeke Strand, Costantino Pitzalis
OBJECTIVE: Because limited data currently support the clinical utility of peripherally expressed biomarkers in guiding treatment decisions for patients with rheumatoid arthritis, the search has turned to the disease tissue. The strategic aim of the Outcome Measures in Rheumatology (OMERACT) synovitis working group over the years has been to develop novel diagnostic and prognostic synovial biomarkers. A critical step in this process is to refine and validate minimally invasive, technically simple, robust techniques to sample synovial tissue, for use both in clinical trials and routine clinical practice...
January 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26024557/giant-solitary-synovial-osteochondroma-of-the-subtalar-joint
#16
Tun Hing Lui
A rapidly progressing calcified mass was found in the left sinus tarsi in a 12-year-old female after a trivial ankle sprain. The lesion mimicked an aggressive lesion clinically and radiographically. Ultrasound-guided biopsy confirmed the diagnosis of a synovial chondroma. Excision of the tumor and partial synovectomy were performed. The histologic diagnosis was a solitary synovial osteochondroma. The condition had not recurred after a follow-up period of 12 months.
January 2016: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/26022188/ultrasound-guided-synovial-biopsy-a-systematic-review-according-to-the-omeract-filter-and-recommendations-for-minimal-reporting-standards-in-clinical-studies
#17
REVIEW
Ilias Lazarou, Maria-Antonietta D'Agostino, Esperanza Naredo, Frances Humby, Andrew Filer, Stephen G Kelly
OBJECTIVES: To describe existing techniques of US-guided synovial biopsy (USG-SB) and critically appraise the literature on this technology through the OMERACT filter. METHODS: USG-SB techniques are described and compared. A systematic literature search of PubMed and Embase was performed for original research reports including US and SB. The subjects, procedure protocols and reported results were analysed. A future research agenda is proposed. RESULTS: USG-SB can be performed using a portal-and-forceps or a dedicated semi-automatic guillotine-type biopsy needle approach...
October 2015: Rheumatology
https://www.readbyqxmd.com/read/25889955/angiogenic-gene-expression-and-vascular-density-are-reflected-in-ultrasonographic-features-of-synovitis-in-early-rheumatoid-arthritis-an-observational-study
#18
Stephen Kelly, Michele Bombardieri, Frances Humby, Nora Ng, Alessandra Marrelli, Sudeh Riahi, Maria DiCicco, Arti Mahto, Lu Zou, Debasish Pyne, Rebecca E Hands, Costantino Pitzalis
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate with clinical disease activity in patients with Rheumatoid Arthritis. This study examines the relationship of US determined synovitis with synovial vascularity, angiogenic/lymphangiogenic factors and cellular mediators of inflammation in a cohort of patients with early Rheumatoid Arthritis (RA) patients prior to therapeutic intervention with disease modifying therapy or corticosteroids...
March 13, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25776646/angiogenic-gene-expression-and-vascular-density-are-reflected-in-ultrasonographic-features-of-synovitis-in-early-rheumatoid-arthritis-an-observational-study
#19
Stephen Kelly, Michele Bombardieri, Frances Humby, Nora Ng, Alessandra Marrelli, Sudeh Riahi, Maria DiCicco, Arti Mahto, Lu Zou, Debasish Pyne, Rebecca E Hands, Costantino Pitzalis
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate with clinical disease activity in patients with Rheumatoid Arthritis. This study examines the relationship of US determined synovitis with synovial vascularity, angiogenic / lymphangiogenic factors and cellular mediators of inflammation in a cohort of patients with early Rheumatoid Arthritis (RA) patients prior to therapeutic intervention with disease modifying therapy or corticosteroids...
December 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25761175/a-case-report-on-the-diagnosis-of-a-rare-pleural-tumor-with-endobronchial-ultrasound-breaking-new-boundaries
#20
Dany Gaspard, Haroon Raja, Rohan Arya, Wissam Abouzgheib, Ziad Boujaoude
Convex endobronchial ultrasound (C-EBUS)-guided transbronchial needle aspiration (TBNA) is an effective tool for the diagnosis of hilar, mediastinal, and central parenchymal lung lesions. However, it has a limited utility for pleural-based masses. We report a unique case of a pleural synovial sarcoma recurrence that was diagnosed by C-EBUS. The patient had a history of inguinal synovial sarcoma. He presented with cough and chest pain. Imaging of chest revealed large right pleural mass. Bronchoscopy with EBUS-TBNA diagnosed pleural recurrence of synovial sarcoma...
March 2015: Medicine (Baltimore)
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