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https://www.readbyqxmd.com/read/29668038/photodynamic-therapy-induces-antifibrotic-alterations-in-primary-human-vocal-fold-fibroblasts
#1
Chi Zhang, Jiajia Wang, Adriana Chou, Ting Gong, Erin E Devine, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind the antifibrotic effects of PDT on primary human vocal fold fibroblasts (VFFs) in vitro. STUDY DESIGN: In vitro analysis from one human donor. METHODS: Cell viability of VFFs in response to varying doses of PDT was investigated by the Cell Counting Kit-8 method...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667150/topical-application-of-omega-3-omega-6-and-omega-9-rich-oil-emulsions-for-cutaneous-wound-healing-in-rats
#2
Wan Maznah Wan Ishak, Haliza Katas, Ng Pei Yuen, Maizaton Atmadini Abdullah, Mohd Hanif Zulfakar
Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the form of oils on wound healing. Linseed (LO), evening primrose (EPO), and olive oils (OO) rich in omega-3, omega-6, and omega-9 fatty acids were formulated into emulsions and were topically applied on rats with excision wounds...
April 17, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29666251/temperature-accelerates-the-rate-fields-become-forests
#3
Jason D Fridley, Justin P Wright
Secondary succession, the postdisturbance transition of herbaceous to woody-dominated ecosystems, occurs faster at lower latitudes with important ramifications for ecosystem processes. This pattern could be driven by the direct effect of temperature on tree growth; however, an alternative mechanism is tree-herb competition, which may be more intense in more fertile northern soils. We manipulated soil fertility and herbaceous species composition in identical experiments at six sites spanning the Eastern United States (30-43° N) and monitored the growth and survival of four early successional trees...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665663/-analysis-of-neoadjuvant-docetaxel-carboplatin-and-trastuzumab-tch-in-her-2-positive-breast-cancer
#4
L Xu, J M Ye, S N Zhu, J Y Zhao, L Xin, Y J Cheng, Q Liu, H Zhang, S Zhang, X N Duan, Y H Liu
Objective: To analyze docetaxel (T) and carboplatin (C) combined with trastuzumab (H) -TCH regimen as neoadjuvant systemic therapy in early breast cancer patients with human epidermal growth factor receptor 2 (HER-2) positive. Methods: From January 2008 to December 2014, the data of patients diagnosed as early breast cancer in Breast Disease Center of Peking University First Hospital were retrospective reviewed. The data of patients with HER-2 positive conducted TCH neoadjuvant therapy and surgery, and with the complete clinicopathological information were analyzed...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29665093/the-mapk-activator-protein-1-signaling-regulates-changes-in-lung-tissue-of-rat-exposed-to-hypobaric-hypoxia
#5
Mrinalini Singh, Seema Yadav, Meetul Kumar, Shweta Saxena, Deepika Saraswat, Anju Bansal, Shashi B Singh
This study reports the role of MAPKs (JNK, ERK, and p38), and activator protein-1 (AP-1) transcription factor in the hypobaric hypoxia induced change in lung tissue. Healthy male Sprague-Dawley rats were exposed to hypobaric hypoxia for 6, 12, 24, 48, 72, and 120 hr. Hypoxia resulted in significant increase in reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and decreased nitric oxide (NO), these act as signaling molecules for activation of MAPK and also contribute in development of vascular leakage (an indicator of pulmonary edema) as confirmed by histological studies...
April 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29665015/the-bacterium-pseudomonas-aeruginosa-senses-and-gradually-responds-to-inter-specific-competition-for-iron
#6
Anne Leinweber, Michael Weigert, Rolf Kümmerli
Phenotypic plasticity in response to competition is a well-described phenomenon in higher organisms. Here, we show that also bacteria have the ability to sense the presence of competitors and mount fine-tuned responses to match prevailing levels of competition. In our experiments, we studied inter-specific competition for iron between the bacterium Pseudomonas aeruginosa (PA) and its competitor Burkholderia cenocepacia (BC). We focused on the ability of PA to phenotypically adjust the production of pyoverdine, an iron-scavenging siderophore...
April 17, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29661920/dhtkd1-deficiency-causes-charcot-marie-tooth-disease-in-mice
#7
Wang-Yang Xu, Houbao Zhu, Yan Shen, Ying-Han Wan, Xiao-Die Tu, Wen-Ting Wu, Lingyun Tang, Hong-Xin Zhang, Shun-Yuan Lu, Xiao-Long Jin, Jian Fei, Zhu-Gang Wang
DHTKD1, a part of 2-ketoadipic acid dehydrogenase complex, is involved in lysine and tryptophan catabolism. Mutations in DHTKD1 block the metabolic pathway and cause 2-aminoadipic and 2-oxoadipic aciduria (AMOXAD), an autosomal recessive inborn metabolic disorder. In addition, a nonsense mutation in DHTKD1 we identified previously causes Charcot-Marie-Tooth disease (CMT) type 2Q, one of the most common inherited neurological disorders affecting the peripheral nerves in the musculature. However, the comprehensive molecular mechanism underlying CMT2Q remains elusive...
April 16, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29661852/integrated-transcriptomic-and-proteomic-analyses-suggest-the-participation-of-endogenous-protease-inhibitors-in-the-regulation-of-protease-gene-expression-in-helicoverpa-armigera
#8
Purushottam R Lomate, Veena Dewangan, Neha Mahajan, Yashwant Kumar, Abhijeet Kulkarni, Li Wang, Smita Saxsena, Vidya S Gupta, Ashok P Giri
Insects adapt to plant protease inhibitors (PIs) present in their diet by differentially regulating multiple digestive proteases. However, mechanisms regulating protease gene expression in insects are largely enigmatic. Ingestion of multi-domain recombinant Capsicum annuum protease inhibitor-7 (CanPI-7) arrests growth and development of Helicoverpa armigera (Lepidoptera: Noctuidae). Using de novo RNA sequencing and proteomic analysis, we examined the response of H. armigera larvae fed on recombinant CanPI-7 at different time intervals...
April 16, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29660695/metabolite-profiles-of-striped-marsh-frog-limnodynastes-peronii-larvae-exposed-to-the-anti-androgenic-fungicides-vinclozolin-and-propiconazole-are-consistent-with-altered-steroidogenesis-and-oxidative-stress
#9
Steven D Melvin, Frederic D L Leusch, Anthony R Carroll
Amphibians use wetlands in urban and agricultural landscapes for breeding, growth and development. Fungicides and other pesticides used in these areas have therefore been identified as potential threats that could contribute towards amphibian population declines. However, relatively little is known about how such chemicals influence sensitive early life-stages or how short episodic exposures influence sub-lethal physiological and metabolic pathways. The present study applied untargeted metabolomics to evaluate effects in early post-hatch amphibian larvae exposed to the anti-androgenic fungicides vinclozolin and propiconazole...
April 11, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29660296/influence-of-aids-antiretroviral-therapy-on-the-growth-pattern
#10
REVIEW
Ana Paula Brigatto Simões Golucci, Fernando Augusto Lima Marson, Mariana Freitas Fedato Valente, Maira Migliari Branco, Camila Carbone Prado, Roberto José Negrão Nogueira
OBJECTIVES: Human immunodeficiency virus infection can result in the early impairment of anthropometric indicators in children and adolescents. However, combined antiretroviral therapy has improved, in addition to the immune response and viral infection, the weight and height development in infected individuals. Therefore, the objective was to evaluate the effect of combined antiretroviral on the growth development of human immunodeficiency virus infected children and adolescents. SOURCE OF DATA: A systematic review was performed...
April 13, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29659581/an-interplay-between-multiple-sirtuins-promotes-completion-of-dna-replication-in-cells-with-short-telomeres
#11
Antoine Simoneau, Étienne Ricard, Hugo Wurtele
The evolutionarily-conserved sirtuin family of histone deacetylases regulates a multitude of DNA-associated processes. A recent genome-wide screen conducted in the yeast Saccharomyces cerevisiae identified Yku70/80, which regulate nonhomologous end-joining (NHEJ) and telomere structure, as being essential for cell proliferation in the presence of the pan-sirtuin inhibitor nicotinamide (NAM). Here, we show that sirtuin-dependent deacetylation of both histone H3 lysine 56 and H4 lysine 16 promotes growth of yku70Δ and yku80Δ cells, and that the NAM sensitivity of these mutants is not caused by defects in double-strand break repair by NHEJ, but rather by their inability to maintain normal telomere length...
April 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29659183/predictors-of-visual-outcomes-in-patients-with-neovascular-age-related-macular-degeneration-treated-with-anti-vascular-endothelial-growth-factor-therapy-post-hoc-analysis-of-the-view-studies
#12
Paolo Lanzetta, Alan F Cruess, Salomon Y Cohen, Jason S Slakter, Todd Katz, Olaf Sowade, Oliver Zeitz, Christiane Ahlers, Paul Mitchell
PURPOSE: Identify predictors for response to anti-vascular endothelial growth factor (VEGF) therapy in patients with neovascular (wet) age-related macular degeneration (nAMD). METHODS: Retrospective, post hoc analysis of VIEW 1/2. Patients were randomized 1:1:1:1 to 0.5 mg intravitreal aflibercept (IVT-AFL) injection every 4 weeks (0.5q4); 2 mg IVT-AFL every 4 weeks (2q4); 2 mg IVT-AFL every 8 weeks (2q8) after an initial three injections at weeks 0, 4 and 8 or 0...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29656165/effect-of-elevated-ozone-and-varying-levels-of-soil-nitrogen-in-two-wheat-triticum-aestivum-l-cultivars-growth-gas-exchange-antioxidant-status-grain-yield-and-quality
#13
Ashutosh K Pandey, Annesha Ghosh, Madhoolika Agrawal, S B Agrawal
Tropospheric ozone (O3 ) is a phytotoxic air pollutant causing a substantial damage to plants and agriculture worldwide. Plant productivity is affected by several environmental factors, which interact with each other. Studies related to interactions involving O3 and different levels of nitrogen (N) are still rare and elusive. In the present study we grew two wheat cultivars (HD2967 and Sonalika) in open top chambers (OTC) under ambient (AO) and elevated O3 (EO) (ambient + 20 ppb O3 ) and provided two levels of N fertilization; (a) recommended nitrogen (RN), (b) 1...
April 12, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29652619/circulating-cytokine-chemokine-concentrations-respond-to-ionizing-radiation-doses-but-not-radiation-dose-rates-granulocyte-colony-stimulating-factor-and-interleukin-18
#14
Juliann G Kiang, Joan T Smith, Sara R Hegge, Natalia I Ossetrova
Exposure to ionizing radiation is a crucial life-threatening factor in nuclear and radiological incidents. It is known that ionizing radiation affects cytokine/chemokine concentrations in the blood of B6D2F1 mice. It is not clear whether radiation dose rates would vary the physiological response. Therefore, in this study we utilized data from two experiments using B6D2F1 female mice exposed to six different dose rates ranging from low to high rates. In one experiment, mice received a total dose of 8 Gy (LD0/30 ) of 60 Co gamma radiation at four dose rates: 0...
April 13, 2018: Radiation Research
https://www.readbyqxmd.com/read/29649816/in-vitro-antichlamydial-activity-of-1-2-3-5-tetrasubstituted-pyrrole-derivatives
#15
Hongzhang Ji, Changyue Wu, Min Ni, Nannan Feng, Chan Wang, Yu Zhao, Lingyan Liu, Shengju Yang, Xiaofeng Bao
BACKGROUND: Chlamydia is a group of bacterial pathogens distributed worldwide that can lead to serious reproductive and other health problems. The rise of antibiotic-resistant pathogens promotes the development of novel antichlamydial agents. The aim of this study is to assess in vitro antichlamydial activity of our previously synthesized 1,2,3,5- tetrasubstituted pyrroles. METHODS: The derivatives were screened for their antichlamydial activity against three Chlamydia strains by calculating IC50 values using concentration-response inhibition data between 1 and 32 μM...
April 12, 2018: Chemotherapy
https://www.readbyqxmd.com/read/29644337/novel-moon-and-mars-partial-gravity-simulation-paradigms-and-their-effects-on-the-balance-between-cell-growth-and-cell-proliferation-during-early-plant-development
#16
Aránzazu Manzano, Raúl Herranz, Leonardus A den Toom, Sjoerd Te Slaa, Guus Borst, Martijn Visser, F Javier Medina, Jack J W A van Loon
Clinostats and Random Positioning Machine (RPM) are used to simulate microgravity, but, for space exploration, we need to know the response of living systems to fractional levels of gravity (partial gravity) as they exist on Moon and Mars. We have developed and compared two different paradigms to simulate partial gravity using the RPM, one by implementing a centrifuge on the RPM (RPMHW ), the other by applying specific software protocols to driving the RPM motors (RPMSW ). The effects of the simulated partial gravity were tested in plant root meristematic cells, a system with known response to real and simulated microgravity...
2018: NPJ Microgravity
https://www.readbyqxmd.com/read/29644001/bag3-promotes-tumour-cell-proliferation-by-regulating-egfr-signal-transduction-pathways-in-triple-negative-breast-cancer
#17
Sarah Shields, Emer Conroy, Tony O'Grady, Alo McGoldrick, Kate Connor, Mark P Ward, Zivile Useckaite, Eugene Dempsey, Rebecca Reilly, Yue Fan, Anthony Chubb, David Gomez Matallanas, Elaine W Kay, Darran O'Connor, Amanda McCann, William M Gallagher, Judith A Coppinger
Triple-negative breast cancer (TNBC), is a heterogeneous disease characterised by absence of expression of the estrogen receptor (ER), progesterone receptor (PR) and lack of amplification of human epidermal growth factor receptor 2 (HER2). TNBC patients can exhibit poor prognosis and high recurrence stages despite early response to chemotherapy treatment. In this study, we identified a pro-survival signalling protein BCL2- associated athanogene 3 (BAG3) to be highly expressed in a subset of TNBC cell lines and tumour tissues...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29643230/the-systemic-response-to-surgery-triggers-the-outgrowth-of-distant-immune-controlled-tumors-in-mouse-models-of-dormancy
#18
Jordan A Krall, Ferenc Reinhardt, Oblaise A Mercury, Diwakar R Pattabiraman, Mary W Brooks, Michael Dougan, Arthur W Lambert, Brian Bierie, Hidde L Ploegh, Stephanie K Dougan, Robert A Weinberg
Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others have proposed that some aspect of surgical tumor resection triggers the outgrowth of otherwise-dormant metastases, leading to the synchronous pattern of relapse. Clinical data cannot distinguish between these hypotheses, and previous experimental approaches have not provided clear answers...
April 11, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29643181/smooth-muscle-cells-differentiated-from-human-mesenchymal-stem-cells-regulated-by-microrna-mir-503-and-mir-222-5p-are-suitable-for-vascular-tissue-engineering
#19
Wenduo Gu, Xuechong Hong, Alexandra Le Bras, Witold N Nowak, Shirin Issa Bhaloo, Jiacheng Deng, Yao Xie, Yanhua Hu, Xiong Z Ruan, Qingbo Xu
Tissue-engineered vascular grafts with long-term patency are greatly needed in the clinical settings, and smooth muscle cells (SMCs) are a critical graft component. Human mesenchymal stem cells (MSCs) are used for generating SMCs and understanding the underlying regulatory mechanisms of the MSC-to-SMC differentiation process could improve SMC generation in the clinic. Here, we found that in response to stimulation of transforming growth factor-β 1 (TGFβ1), human umbilical cord-derived MSCs abundantly express the SMC markers α-smooth muscle actin (αSMA), smooth muscle protein 22 (SM22), calponin and smooth muscle myosin heavy chain (SMMHC) at both gene and protein levels...
April 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29628021/regulation-by-3-5-3-tri-iodothyronine-and-fsh-of-cytochrome-p450-family-19-cyp19-expression-in-mouse-granulosa-cells
#20
Juan Liu, Yingying Han, Ye Tian, Xuechun Weng, Xusong Hu, Wenbo Liu, Dai Heng, Kaili Xu, Yanzhou Yang, Cheng Zhang
Cytochrome P450 family 19 (CYP19) plays an important role in follicular development, which is regulated by FSH. Although 3,5,3'-tri-iodothyronine (T3) combines with FSH to induce preantral follicle growth and granulosa cell development, the mechanism involved remains unclear. The aim of the present study was to determine the cellular and molecular mechanisms by which thyroid hormone (TH) and FSH regulate CYP19 expression and sterol biosynthesis during preantral follicle growth. Mice were injected subcutaneously (s...
April 9, 2018: Reproduction, Fertility, and Development
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