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https://www.readbyqxmd.com/read/29908008/long-term-cadmium-exposure-influences-the-abundance-of-proteins-that-impact-the-cell-wall-structure-in-medicago-sativa-stems
#1
Annelie Gutsch, Els Keunen, Gea Guerriero, Jenny Renaut, Ann Cuypers, Jean-François Hausman, Kjell Sergeant
Cadmium (Cd) is a non-essential, toxic heavy metal that poses serious threats to both the ecosystem and the health of humans. Plants employ various cellular and molecular mechanisms to minimize the impact of Cd toxicity and the cell walls function as defensive barrier during Cd exposure. In this study, we adopted a quantitative gel-based proteomic approach (two-dimensional difference gel electrophoresis) to investigate changes in the abundance of cell wall- and soluble proteins in stems of Medicago sativa L...
June 15, 2018: Plant Biology
https://www.readbyqxmd.com/read/29907707/-leishmania-donovani-exploits-tollip-a-multitasking-protein-to-impair-tlr-il-1r-signaling-for-its-survival-in-the-host
#2
Naveen Parmar, Pragya Chandrakar, Preeti Vishwakarma, Kavita Singh, Kalyan Mitra, Susanta Kar
IL-1R/TLR signaling plays a significant role in sensing harmful foreign pathogens and mounting effective innate and adaptive immune responses. However, the precise mechanism by which Leishmania donovani, an obligate intramacrophagic pathogen, breaches IL-1R/TLR signaling and host-protective immunity remains obscure. In this study, we report the novel biphasic role of Toll-interacting protein (Tollip), a negative regulator of the IL-1R/TLR pathway, in the disease progression of experimental visceral leishmaniasis...
June 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29907230/a-novel-retinoid-x-receptor-agonist-uab30-inhibits-rhabdomyosarcoma-cells-in-vitro
#3
Adele P Williams, Alicia M Waters, Jerry E Stewart, Venkatram R Atigadda, Elizabeth Mroczek-Musulman, Donald D Muccio, Clinton J Grubbs, Elizabeth A Beierle
BACKGROUND: While patients with early-stage rhabdomyosarcoma (RMS) have seen steady improvement in prognosis over the last 50 y, those with advanced-stage or high-grade disease continue to have a dismal prognosis. Retinoids have been shown to cause growth suppression and terminal differentiation in RMS cells, but the toxicities associated with retinoic acid limit its use. Rexinoids provide an alternative treatment approach to retinoic acid. Rexinoids primarily bind the retinoid X receptor with minimal retinoic acid receptor binding, the entity responsible for many of the toxicities of retinoid therapies...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907114/amelogenesis-imperfecta-therapeutic-strategy-from-primary-to-permanent-dentition-across-case-reports
#4
Steve Toupenay, Benjamin Philippe Fournier, Marie-Cécile Manière, Chantal Ifi-Naulin, Ariane Berdal, Muriel de La Dure-Molla
BACKGROUND: Hereditary enamel defect diseases are regrouped under the name "Amelogenesis Imperfecta" (AIH). Both dentitions are affected. Clinical expression is heterogeneous and varies between patients. Mutations responsible for this multigene disease may alter various genes and the inheritance can be either autosomal dominant or recessive, or X-linked. Until now, no therapeutic consensus has emerged for this rare disease. CASE PRESENTATION: The purpose of this article was to report treatments of AIH patients from childhood to early adulthood...
June 15, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29906627/substrate-micropatterns-produced-by-polymer-demixing-regulate-focal-adhesions-actin-anisotropy-and-lineage-differentiation-of-stem-cells
#5
Sebastián L Vega, Varun Arvind, Prakhar Mishra, Joachim Kohn, N Sanjeeva Murthy, Prabhas V Moghe
Stem cells are adherent cells whose multipotency and differentiation can be regulated by numerous microenvironmental signals including soluble growth factors and surface topography. This study describes a simple method for creating distinct micropatterns via microphase separation resulting from polymer demixing of poly(desaminotyrosyl-tyrosine carbonate) (PDTEC) and polystyrene (PS). Substrates with co-continuous (ribbons) or discontinuous (islands and pits) PDTEC regions were obtained by varying the ratio of PDTEC and sacrificial PS...
June 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29906413/a-snap-25-cleaving-chimera-of-botulinum-neurotoxin-a-and-e-prevents-tnf%C3%AE-induced-elevation-of-the-activities-of-native-trp-channels-on-early-postnatal-rat-dorsal-root-ganglion-neurons
#6
Marc Nugent, Yamil R Yusef, Jianghui Meng, Jiafu Wang, J Oliver Dolly
Transient receptor potential (TRP) vallinoid 1 (TRPV1) and ankyrin 1 (TRPA1) are two transducing channels expressed on peripheral sensory nerves involved in pain sensation. Upregulation of their expression, stimulated by inflammatory cytokines and growth factors in animal pain models, correlate with the induction of nociceptive hyper-sensitivity. Herein, we firstly demonstrate by immuno-cytochemical labelling that TNFα augments the surface content of these channels on rat cultured dorsal root ganglion (DRG) neurons which, in turn, enhances the electrophysiological and functional responses of the latter to their specific agonists...
June 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29905975/the-grk2-promoter-is-regulated-by-early-growth-response-transcription-factor-egr-1
#7
Stefanie Klenke, Andrea Engler, Daniel Ecker, Crista Ochsenfarth, Nina Danowski, Jürgen Peters, Winfried Siffert, Ulrich H Frey
The G-protein-coupled receptor kinase 2 (GRK2) plays a major role in cardiovascular diseases and its expression is increased in heart failure. However, only little is known about factors being involved in up-regulation of GRK2 expression through transcriptional regulation of its promoter. Since the transcription factor early-growth response 1 (EGR-1) is also up-regulated in patients with heart failure, we tested the hypothesis that EGR-1 regulates GRK2 transcription. Stimulation of immortalized rat cardiomyocytes (H9c2) with phorbol 12-myristate 13-acetate (PMA) resulted in up-regulation of Egr-1 and subsequently of Grk2 mRNA expression, with maximum Grk2 expression (p=0...
June 15, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29905795/genetic-relationships-of-antibody-response-viremia-level-and-weight-gain-in-pigs-experimentally-infected-with-porcine-reproductive-and-respiratory-syndrome-virus
#8
A S Hess, B R Trible, M K Hess, R R R Rowland, J K Lunney, G S Plastow, J C M Dekkers
Genetic and antigenic variability between Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) isolates has encumbered vaccine development. Here, the genetic basis of PRRSV antibody response was assessed using data from experimental infection trials of commercial crossbred weaner pigs across with one of two distinct PRRSV isolates, NVSL-97-7895 (~750 pigs) and KS-2006-72109 (~450 pigs). Objectives were to estimate the genetic parameters of antibody response, measured as the sample to positive ratio (S:P) of PRRSV N-protein specific IgG in serum at 42 days post infection (dpi); assess the relationship of S:P at 42 dpi with serum viremia and growth under infection; and identify genomic regions associated with S:P at 42 dpi...
June 14, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29904166/pharmacological-activation-of-epidermal-growth-factor-receptor-signaling-inhibits-colitis-associated-cancer-in-mice
#9
Philip E Dubé, Cambrian Y Liu, Nandini Girish, M Kay Washington, D Brent Polk
Current treatments for inflammatory bowel disease (IBD) target the overactive immune response of the intestinal mucosa. However, epidermal growth factor (EGF), an activating ligand of the EGF receptor (EGFR), has been shown to induce disease remission through direct targeting of intestinal mucosal healing. Despite promising preclinical and clinical results, this EGFR-activating therapy has not progressed, in part due to the potential for carcinogenesis associated with long-term use and the increased risk of colitis-associated cancer (CAC) in IBD...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29904092/deep-transcriptomic-analysis-of-black-rockfish-sebastes-schlegelii-provides-new-insights-on-responses-to-acute-temperature-stress
#10
Likang Lyu, Haishen Wen, Yun Li, Jifang Li, Ji Zhao, Simin Zhang, Min Song, Xiaojie Wang
In the present study, we conducted an RNA-Seq analysis to characterize the genes and pathways involved in acute thermal and cold stress responses in the liver of black rockfish, a viviparous teleost that has the ability to cope with a wide range of temperature changes. A total of 584 annotated differentially expressed genes (DEGs) were identified in all three comparisons (HT vs NT, HT vs LT and LT vs NT). Based on an enrichment analysis, DEGs with a potential role in stress accommodation were classified into several categories, including protein folding, metabolism, immune response, signal transduction, molecule transport, membrane, and cell proliferation/apoptosis...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902178/performance-of-four-crop-model-for-simulations-of-wheat-phenology-leaf-growth-biomass-and-yield-across-planting-dates
#11
Jamshad Hussain, Tasneem Khaliq, Ashfaq Ahmad, Javed Akhtar
Robustness of four wheat simulation model were tested with 2-year field experiments of three cultivars across a wide range of sowing dates in two different climatic regions: Faisalabad (semi-arid) and Layyah (arid), in Punjab-Pakistan. Wheat growing season temperature ranged from -0.1°C to 43°C. The wide series of sowing dates was a unique opportunity to grow the wheat in an environment which temperatures varies from -0.1°C to 43°C. The CERES-Wheat, Nwheat, CROPSIM-Wheat and APSIM-Wheat model were calibrated against the least-stressed treatment for each wheat cultivar...
2018: PloS One
https://www.readbyqxmd.com/read/29901781/exposure-to-heavy-metal-stress-triggers-changes-in-plasmodesmatal-permeability-via-deposition-and-breakdown-of-callose
#12
Ruthsabel O'Lexy, Koji Kasai, Natalie Clark, Toru Fujiwara, Rosangela Sozzani, Kimberly L Gallagher
Both plants and animals must contend with changes in their environment. The ability to respond appropriately to these changes often underlies the ability of the individual to survive. In plants, an early response to environmental stress is an alteration in plasmodesmatal permeability with accompanying changes in cell to cell signaling. However, the ways in which plasmodesmata are modified, the molecular players involved in this regulation, and the biological significance of these responses are not well understood...
June 13, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29900164/bartter-syndrome-type-3-phenotype-genotype-correlation-and-favorable-response-to-ibuprofen
#13
Xuejun Yang, Gaofu Zhang, Mo Wang, Haiping Yang, Qiu Li
Objective: To investigate the phenotype-genotype correlation in different genetic kinds of Bartter syndrome type 3 in children. Methods: Clinical and genetic data of 2 patients with different mutations in Bartter syndrome type 3 was analyzed while the prognosis was compared after a 6-year follow-up or 2-year follow-up, respectively. Results: Bartter syndrome is a kind of autosomal recessive inherited renal disorder. The manifestation and prognosis of Bartter syndrome change with mutation types, and severe mutation were often accompanied with unfavorable prognosis...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29899739/marked-response-in-microbial-community-and-metabolism-in-the-ileum-and-cecum-of-suckling-piglets-after-early-antibiotics-exposure
#14
Miao Yu, Chunlong Mu, Chuanjian Zhang, Yuxiang Yang, Yong Su, Weiyun Zhu
In modern swine husbandry systems, antibiotics have been used as growth promoters for piglets during suckling or weaning period. However, while early colonization of intestinal microbiota has been regarded crucial for the host's later life performance and well-being, little is known about the impact of antibiotics on intestinal microbiota in suckling piglets. The present study aimed to investigate the effects of early antibiotics exposure on gut microbiota and microbial metabolism of suckling piglets. Sixteen litters of suckling piglets were fed a creep feed diet with (Antibiotic) or without (Control) antibiotics from postnatal days 7-23 ( n = 8)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29898762/identifying-an-early-treatment-window-for-predicting-breast-cancer-response-to-neoadjuvant-chemotherapy-using-immunohistopathology-and-hemoglobin-parameters
#15
Quing Zhu, Susan Tannenbaum, Scott H Kurtzman, Patricia DeFusco, Andrew Ricci, Hamed Vavadi, Feifei Zhou, Chen Xu, Alex Merkulov, Poornima Hegde, Mark Kane, Liqun Wang, Kert Sabbath
BACKGROUND: Breast cancer pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) varies with tumor subtype. The purpose of this study was to identify an early treatment window for predicting pCR based on tumor subtype, pretreatment total hemoglobin (tHb) level, and early changes in tHb following NAC. METHODS: Twenty-two patients (mean age 56 years, range 34-74 years) were assessed using a near-infrared imager coupled with an Ultrasound system prior to treatment, 7 days after the first treatment, at the end of each of the first three cycles, and before their definitive surgery...
June 14, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29898187/oral-implant-osseointegration-model-in-c57bl-6-mice-microtomographic-histological-histomorphometric-and-molecular-characterization
#16
Claudia Cristina Biguetti, Franco Cavalla, Elcia M Silveira, Angélica Cristina Fonseca, Andreia Espindola Vieira, Andre Petenuci Tabanez, Danieli C Rodrigues, Ana Paula Favaro Trombone, Gustavo Pompermaier Garlet
INTRODUCTION: Despite the successful clinical application of titanium (Ti) as a biomaterial, the exact cellular and molecular mechanisms responsible for Ti osseointegration remains unclear, especially because of the limited methodological tools available in this field. OBJECTIVE: In this study, we present a microscopic and molecular characterization of an oral implant osseointegration model using C57Bl/6 mice. MATERIAL AND METHODS: Forty-eight male wild-type mice received a Ti implant on the edentulous alveolar crest and the peri-implant sites were evaluated through microscopic (μCT, histological and birefringence) and molecular (RealTimePCRarray) analysis in different points in time after surgery (3, 7, 14 and 21 days)...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29897997/the-exposure-to-uteroplacental-insufficiency-is-associated-with-activation-of-unfolded-protein-response-in-postnatal-life
#17
Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR). A significantly increased expression of X-box binding protein-1 spliced (XBP1s) mRNA (p<0.01), Endoplasmic Reticulum-localized DnaJ homologue (Erdj4) mRNA (p<0...
2018: PloS One
https://www.readbyqxmd.com/read/29897966/salinity-reduction-benefits-european-eel-larvae-insights-at-the-morphological-and-molecular-level
#18
Sebastian N Politis, David Mazurais, Arianna Servili, Jose-Luis Zambonino-Infante, Joanna J Miest, Jonna Tomkiewicz, Ian A E Butts
European eel (Anguilla anguilla) is a euryhaline species, that has adapted to cope with both, hyper- and hypo-osmotic environments. This study investigates the effect of salinity, from a morphological and molecular point of view on European eel larvae reared from 0 to 12 days post hatch (dph). Offspring reared in 36 practical salinity units (psu; control), were compared with larvae reared in six scenarios, where salinity was decreased on 0 or 3 dph and in rates of 1, 2 or 4 psu/day, towards iso-osmotic conditions...
2018: PloS One
https://www.readbyqxmd.com/read/29896192/outgrowing-the-immaturity-myth-the-cost-of-defending-from-neonatal-infectious-disease
#19
Danny Harbeson, Rym Ben-Othman, Nelly Amenyogbe, Tobias R Kollmann
Newborns suffer high rates of mortality due to infectious disease-this has been generally regarded to be the result of an "immature" immune system with a diminished disease-fighting capacity. However, the immaturity dogma fails to explain (i) greater pro-inflammatory responses than adults in vivo and (ii) the ability of neonates to survive a significantly higher blood pathogen burden than of adults. To reconcile the apparent contradiction of clinical susceptibility to disease and the host immune response findings when contrasting newborn to adult, it will be essential to capture the entirety of available host-defense strategies at the newborn's disposal...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29894705/plasma-biomarkers-in-a-placebo-controlled-trial-comparing-tdcs-and-escitalopram-efficacy-in-major-depression
#20
André R Brunoni, Frank Padberg, Erica Leandro Marciano Vieira, Antônio Lucio Teixeira, André F Carvalho, Paulo Andrade Lotufo, Wagner F Gattaz, Isabela Martins Benseñor
BACKGROUND: Transcranial direct current stimulation (tDCS) holds promise as a therapeutic intervention for major depressive disorder (MDD). A more precise understanding of its underlying mechanisms may aid in the identification of subsets of patients responsive to tDCS within the context of precision psychiatry. OBJECTIVE: In this ancillary investigation of the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS), we investigated whether plasma levels of several cytokines and neurotrophic factors associated with major depression or antidepressant response predicted tDCS effects...
June 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
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