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https://www.readbyqxmd.com/read/28437785/the-retina-of-asian-and-african-elephants-comparison-of-newborn-and-adult
#1
Heidrun Kuhrt, Andreas Bringmann, Wolfgang Härtig, Gudrun Wibbelt, Leo Peichl, Andreas Reichenbach
Elephants are precocial mammals that are relatively mature as newborns and mobile shortly after birth. To determine whether the retina of newborn elephants is capable of supporting the mobility of elephant calves, we compared the retinal structures of 2 newborn elephants (1 African and 1 Asian) and 2 adult animals of both species by immunohistochemical and morphometric methods. For the first time, we present here a comprehensive qualitative and quantitative characterization of the cellular composition of the newborn and the adult retinas of 2 elephant species...
April 25, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28433774/the-role-of-compensatory-health-beliefs-in-eating-behavior-change-a-mixed-method-study
#2
Melanie A Amrein, Pamela Rackow, Jennifer Inauen, Theda Radtke, Urte Scholz
Compensatory Health Beliefs (CHBs), defined as beliefs that an unhealthy behavior can be compensated for by engaging in another healthy behavior, are assumed to hinder health behavior change. The aim of the present study was to investigate the role of CHBs for two distinct eating behaviors (increased fruit and vegetable consumption and eating fewer unhealthy snacks) with a mixed method approach. Participants (N = 232, mean age = 27.3 years, 76.3% women) were randomly assigned to a fruit and vegetable or an unhealthy snack condition...
April 19, 2017: Appetite
https://www.readbyqxmd.com/read/28432253/ten-minute-chat
#3
Melissa Kelson
Melissa Kelson is a fourth year student at the Royal Veterinary College. She recently spent a week of her EMS with the BVA's journals.
April 22, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28425777/self-reported-dependence-on-mobile-phones-in-young-adults-a-european-cross-cultural-empirical-survey
#4
Olatz Lopez-Fernandez, Daria J Kuss, Lucia Romo, Yannick Morvan, Laurence Kern, Pierluigi Graziani, Amélie Rousseau, Hans-Jürgen Rumpf, Anja Bischof, Ann-Kathrin Gässler, Adriano Schimmenti, Alessia Passanisi, Niko Männikkö, Maria Kääriänen, Zsolt Demetrovics, Orsolya Király, Mariano Chóliz, Juan José Zacarés, Emilia Serra, Mark D Griffiths, Halley M Pontes, Bernadeta Lelonek-Kuleta, Joanna Chwaszcz, Daniele Zullino, Lucien Rochat, Sophia Achab, Joël Billieux
Background and aims Despite many positive benefits, mobile phone use can be associated with harmful and detrimental behaviors. The aim of this study was twofold: to examine (a) cross-cultural patterns of perceived dependence on mobile phones in ten European countries, first, grouped in four different regions (North: Finland and UK; South: Spain and Italy; East: Hungary and Poland; West: France, Belgium, Germany, and Switzerland), and second by country, and (b) how socio-demographics, geographic differences, mobile phone usage patterns, and associated activities predicted this perceived dependence...
April 20, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28420875/down-regulation-of-cholinergic-signaling-in-the-habenula-induces-anhedonia-like-behavior
#5
Seungrie Han, Soo Hyun Yang, Jin Yong Kim, Seojung Mo, Esther Yang, Ki Myung Song, Byung-Joo Ham, Naguib Mechawar, Gustavo Turecki, Hyun Woo Lee, Hyun Kim
Dysfunction of cholinergic signaling in the brain has long been believed to be associated with depressive disorders. However, the functional impact of habenular cholinergic signaling on the specified depressive behaviors is not well understood. Here, we demonstrated that the expression levels of cholinergic signaling genes (CHAT, VACHT, CHT, CHRNA3, CHRNB3 and CHRNB4) were down-regulated in a chronic restraint stress (CRS) rat model of depression, in which rats display depression-like behaviors such as anhedonia and mood despair...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28419375/transcriptional-profiling-of-cholinergic-neurons-from-basal-forebrain-identifies-changes-in-expression-of-genes-between-sleep-and-wake-mrna-profiling-in-basal-forebrain-with-sleep-sleep-deprivation
#6
Elena V Nikonova, Jason DA Gilliland, Keith Q Tanis, Alexei A Podtelezhnikov, Alison M Rigby, Raymond J Galante, Eva M Finney, David J Stone, John J Renger, Allan I Pack, Christopher J Winrow
Study objective: To assess differences in gene expression in cholinergic basal forebrain cells between sleeping and sleep deprived mice sacrificed at the same time of day. Methods: Tg(ChAT-eGFP)86Gsat mice expressing eGFP under control of the choline acetyltransferase (Chat) promoter were utilized to guide laser capture of cholinergic cells in basal forebrain. mRNA expression levels in these cells were profiled using microarrays. Gene expression in eGFP(+) neurons was compared (1) to that in eGFP(-) neurons and to adjacent white matter, (2) between 7:00 am (lights on) and 7:00 pm (lights off), (3) between sleep deprived and sleeping animals at 0, 3, 6, 9 hrs from lights on...
April 13, 2017: Sleep
https://www.readbyqxmd.com/read/28414442/stolonidiol-synthesis-target-identification-and-mechanism-for-choline-acetyltransferase-activation
#7
Jeremy W Mason, Cullen L Schmid, Laura M Bohn, William R Roush
Stolonidiol, a marine natural product, has been reported to potentiate the activity of choline acetyltransferase (ChAT), the enzyme that produces the neurotransmitter acetylcholine. Here we report the total synthesis of stolonidiol starting from (R)-(+)-limonene. To identify the mechanism by which ChAT activity is increased, we sought to identify the biological target of stolonidiol. We show that stolonidiol binds to the phorbol ester binding site of protein kinase C (PKC), induces translocation of PKC to the cell membrane, and activates kinase activity...
April 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28413987/alzheimer-s-disease-like-early-phase-brain-pathogenesis-self-curing-amelioration-of-neurodegeneration-from-pro-inflammatory-wounding-to-anti-inflammatory-healing
#8
Jiang He, Tao Liao, Guo-Xin Zhong, Ji-Da Zhang, Yan-Ping Chen, Qi Wang, Qing-Ping Zeng
The etiological initiators of neuroinflammation remain inclusive, and effective interventions to block neurodegeneration are unavailable. Surprisingly, we found collagen II-combined complete Freund's adjuvant (CC) that usually induces rheumatoid arthritis (RA) also drives Alzheimer's disease (AD)-like neurodegeneration in mice. CC not only upregulates the cerebral pro-inflammatory cytokines including tumor necrosis factor α (TNF-α) and interleukin 8 (IL-8), but also downregulates the cerebral interleukin 10 (IL-10), an anti-inflammatory cytokine, and tyrosine hydroxylase (TH), a rate-limiting enzyme for biosynthesis of the anti-inflammatory neurotransmitter dopamine...
April 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28410183/online-versus-telephone-methods-to-recruit-and-interview-older-gay-and-bisexual-men-treated-for-prostate-cancer-findings-from-the-restore-study
#9
B R Simon Rosser, Benjamin Capistrant
BACKGROUND: Recently, researchers have faced the challenge of conflicting recommendations for online versus traditional methods to recruit and interview older, sexual minority men. Older populations represent the cohort least likely to be online, necessitating the use of traditional research methods, such as telephone or in-person interviews. By contrast, gay and bisexual men represent a population of early adopters of new technology, both in general and for medical research. In a study of older gay and bisexual men with prostate cancer, we asked whether respondents preferred online versus offline methods for data collection...
July 19, 2016: JMIR Cancer
https://www.readbyqxmd.com/read/28409485/cohesion-network-analysis-of-cscl-participation
#10
Mihai Dascalu, Danielle S McNamara, Stefan Trausan-Matu, Laura K Allen
The broad use of computer-supported collaborative-learning (CSCL) environments (e.g., instant messenger-chats, forums, blogs in online communities, and massive open online courses) calls for automated tools to support tutors in the time-consuming process of analyzing collaborative conversations. In this article, the authors propose and validate the cohesion network analysis (CNA) model, housed within the ReaderBench platform. CNA, grounded in theories of cohesion, dialogism, and polyphony, is similar to social network analysis (SNA), but it also considers text content and discourse structure and, uniquely, uses automated cohesion indices to generate the underlying discourse representation...
April 13, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28408940/laser-acupuncture-exerts-neuroprotective-effects-via-regulation-of-creb-bdnf-bcl-2-and-bax-gene-expressions-in-the-hippocampus
#11
Yeong-Chan Yun, Dongyeop Jang, Sun-Bee Yoon, Dohyeong Kim, Dong-Hee Choi, O-Sang Kwon, Yu-Mi Lee, Daehwan Youn
Acupuncture has a positive effect on cognitive deficits. However, the effects of laser acupuncture (LA) on cognitive function and its mechanisms of action are unclear. The present study aimed to evaluate the effects of LA on middle cerebral artery occlusion- (MCAO-) induced cognitive impairment and its mechanisms of action. Transient focal cerebral ischemia was modeled in adult Sprague-Dawley rats by MCAO. After LA or manual-acupuncture (MA) treatment at the GV20 and HT7 for 2 weeks, hippocampal-dependent memory was evaluated using the Morris water maze (MWM) test...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28402924/remote-tele-mentored-ultrasound-for-non-physician-learners-using-facetime-a-feasibility-study-in-a-low-income-country
#12
Thomas E Robertson, Andrea R Levine, Avelino C Verceles, Jessica A Buchner, James H Lantry, Alfred Papali, Marc T Zubrow, L Nathalie Colas, Marc E Augustin, Michael T McCurdy
PURPOSE: Ultrasound (US) is a burgeoning diagnostic tool and is often the only available imaging modality in low- and middle-income countries (LMICs). However, bedside providers often lack training to acquire or interpret US images. We conducted a study to determine if a remote tele-intensivist could mentor geographically removed LMIC providers to obtain quality and clinically useful US images. MATERIALS AND METHODS: Nine Haitian non-physician health care workers received a 20-minute training on basic US techniques...
April 7, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28397428/neuroprotective-effects-of-erythropoietin-on-alzheimer-s-dementia-model-in-rats
#13
Betul Cevik, Volkan Solmaz, Gurkan Yigitturk, Turker Cavusoğlu, Gonul Peker, Oytun Erbas
BACKGROUND: Although Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and characterized by memory impairment, only symptomatic treatments are available. OBJECTIVES: Because recombinant human erythropoietin (rhEPO) has various neuroprotective effects and improves cognitive function in animal models of neurodegenerative disorders, we investigated the therapeutic effects of rhEPO in an intracerebroventricular (ICV)-streptozotocin (STZ) animal model of sporadic-AD...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28392569/multichannel-polymer-scaffold-seeded-with-activated-schwann-cells-and-bone-mesenchymal-stem-cells-improves-axonal-regeneration-and-functional-recovery-after-rat-spinal-cord-injury
#14
Er-Zhu Yang, Guo-Wang Zhang, Jian-Guang Xu, Shuai Chen, Hua Wang, Liang-Liang Cao, Bo Liang, Xiao-Feng Lian
The adult mammalian CNS has a limited capacity to regenerate after traumatic injury. In this study, a combinatorial strategy to promote axonal regeneration and functional recovery after spinal cord injury (SCI) was evaluated in adult rats. The rats were subjected to a complete transection in the thoracic spinal cord, and multichannel scaffolds seeded with activated Schwann cells (ASCs) and/or rat bone marrow-derived mesenchymal stem cells (MSCs) were acutely grafted into the 3-mm-wide transection gap. At 4 weeks post-transplantation and thereafter, the rats receiving scaffolds seeded with ASCs and MSCs exhibited significant recovery of nerve function as shown by the Basso, Beattie and Bresnahan (BBB) score and electrophysiological test results...
April 10, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28383527/activation-of-the-hypoglossal-to-tongue-musculature-motor-pathway-by-remote-control
#15
Garret A Horton, Jimmy J Fraigne, Zoltan A Torontali, Matthew B Snow, Jennifer L Lapierre, Hattie Liu, Gaspard Montandon, John H Peever, Richard L Horner
Reduced tongue muscle tone precipitates obstructive sleep apnea (OSA), and activation of the tongue musculature can lessen OSA. The hypoglossal motor nucleus (HMN) innervates the tongue muscles but there is no pharmacological agent currently able to selectively manipulate a channel (e.g., Kir2.4) that is highly restricted in its expression to cranial motor pools such as the HMN. To model the effect of manipulating such a restricted target, we introduced a "designer" receptor into the HMN and selectively modulated it with a "designer" drug...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28378675/student-life-student-to-newly-qualified-nurse-make-a-checklist
#16
Jessica Ross
It is natural to feel nervous and apprehensive on your first day in uniform, but hopefully you will also feel excited. Your first day is a celebration of all the hard-won achievements throughout your training, so here are a few tips to help you make the most of it: » Organise a ward induction beforehand, or have a look around. Knowing where you are going and what your workplace looks like can help quell your nerves. » Running around trying to find a pair of scrubs to wear during handover is not ideal, so see if you can get your uniform in advance...
April 5, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28374929/age-related-differences-in-prevalence-of-autism-spectrum-disorder-symptoms-in-children-and-adolescents-with-costello-syndrome
#17
David D Schwartz, Jennifer M Katzenstein, Eric J Highley, Deborah L Stabley, Katia Sol-Church, Karen W Gripp, Marni E Axelrad
Dysregulation of the mitogen activated protein kinase (MAPK) pathway in Costello syndrome (CS) may contribute to increased risk for autism-spectrum disorder (ASD). We examined prevalence of ASD symptoms in 14 individuals (six females) age 1-18 years with molecularly confirmed CS. Caregivers completed the Modified Checklist for Autism in Toddlers (M-CHAT) for ages 0-4 years (n = 7), and the Social Communication Questionnaire (SCQ) for ages 4 and older (n = 7). Age was associated with meeting ASD criteria: 5/7 (71...
May 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28369825/cholinergic-and-dopaminergic-neuronal-differentiation-of-human-adipose-tissue-derived-mesenchymal-stem-cells
#18
H E Marei, A El-Gamal, A Althani, N Afifi, A Abd-Elmaksoud, A Farag, C Cenciarelli, Thomas Caceci, Anwarul Hasan
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell types such as cartilage, bone, and fat cells. Recent studies have shown that induction of MSCs in vitro by growth factors including epidermal growth factor (EGF) and fibroblast growth factor (FGF2) causes them to differentiate into neural like cells. These cultures also express ChAT, a cholinergic marker; and TH, a dopaminergic marker for neural cells. To establish a protocol with maximum differentiation potential, we examined MSCs under three experimental culture conditions using neural induction media containing FGF2, EGF, BMP-9, retinoic acid and heparin...
March 30, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28356720/mhealth-intervention-to-support-asthma-self-management-in-adolescents-the-adapt-study
#19
Richelle C Kosse, Marcel L Bouvy, Tjalling W de Vries, Ad A Kaptein, Harm Cj Geers, Liset van Dijk, Ellen S Koster
PURPOSE: Poor medication adherence in adolescents with asthma results in poorly controlled disease and increased morbidity. The aim of the ADolescent Adherence Patient Tool (ADAPT) study is to develop an mHealth intervention to support self-management and to evaluate the effectiveness in improving medication adherence and asthma control. INTERVENTION: The ADAPT intervention consists of an interactive smartphone application (app) connected to a desktop application for health care providers, in this study, the community pharmacist...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28351018/profiles-of-amino-acids-and-biogenic-amines-in-the-plasma-of-cri-du-chat-patients
#20
Danielle Zildeana Sousa Furtado, Fernando Brunale Vilela de Moura Leite, Cleber Nunes Barreto, Bernadete Faria, Leticia Dias Lima Jedlicka, Elisângela de Jesus Silva, Heron Dominguez Torres da Silva, Etelvino Jose Henriques Bechara, Nilson Antonio Assunção
Cri-du-chat syndrome (CDCS) is a rare innate disease attributed to chromosome 5p deletion characterized by a cat-like cry, craniofacial malformation, and altered behavior of affected children. Metabolomic analysis and a chemometric approach allow description of the metabolic profile of CDCS as compared to normal subjects. In the present work, UHPLC/MS was employed to analyze blood samples withdrawn from CDCS carriers (n=18) and normal parental subjects (n=18), all aged 0-34 years, aiming to set up a representative CDCS profile constructed from 33 targeted amino acids and biogenic amines...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
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