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https://www.readbyqxmd.com/read/29343737/moderate-decline-in-select-synaptic-markers-in-the-prefrontal-cortex-ba9-of-patients-with-alzheimer-s-disease-at-various-cognitive-stages
#1
Odile Poirel, Sébastien Mella, Catherine Videau, Lauriane Ramet, Maria Antonietta Davoli, Etienne Herzog, Pavel Katsel, Naguib Mechawar, Vahram Haroutunian, Jacques Epelbaum, Stéphanie Daumas, Salah El Mestikawy
Synaptic loss, plaques and neurofibrillary tangles are viewed as hallmarks of Alzheimer's disease (AD). This study investigated synaptic markers in neocortical Brodmann area 9 (BA9) samples from 171 subjects with and without AD at different levels of cognitive impairment. The expression levels of vesicular glutamate transporters (VGLUT1&2), glutamate uptake site (EAAT2), post-synaptic density protein of 95 kD (PSD95), vesicular GABA/glycine transporter (VIAAT), somatostatin (som), synaptophysin and choline acetyl transferase (ChAT) were evaluated...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335488/distinct-erp-profiles-for-auditory-processing-in-infants-at-risk-for-autism-and-language-impairment
#2
Valentina Riva, Chiara Cantiani, Giulia Mornati, Martina Gallo, Laura Villa, Elisa Mani, Irene Saviozzi, Cecilia Marino, Massimo Molteni
Early identification of autism spectrum disorder (ASD) is crucial for the formulation of effective intervention programs. Language deficits may be a hallmark feature of ASD and language delay observed in ASD shows striking similarities to that observed in children with language impairment (LI). Auditory processing deficits are seen in both LI and ASD, however, they have not previously been compared directly using Event-Related Potentials (ERPs) in the two at-risk populations. This study aims to characterize infants at-risk for ASD (HR-ASD) at the electrophysiological level and to compare them with infants at-risk for LI (HR-LI) and controls, to find specific markers with predictive value...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334765/examining-use-of-mobile-phones-for-sleep-tracking-among-a-national-sample-in-the-usa
#3
Rebecca Robbins, Paul Krebs, David M Rapoport, Girardin Jean-Louis, Dustin T Duncan
Mobile technology has been designed to serve a number of functions relating to health, but we know little about individuals who use these tools to track sleep. This study utilized data from a cross-sectional, geographically diverse survey of adults in the USA (N = 934). Among the sample, 28.2% (n = 263) report current use of a mobile phone for sleep tracking. Income and gender were significant correlates of sleep tracking (p < 0.05). Compared to a poor diet, a reported "excellent" diet was associated with sleep tracking (p < 0...
January 15, 2018: Health Communication
https://www.readbyqxmd.com/read/29332112/evaluation-of-effectiveness-of-peer-education-on-smoking-behavior-among-high-school-students
#4
Nurcan Bilgiç, Türkan Günay
To evaluate the effectiveness of peer education on changing the smoking behavior of high schoolage children's.  Methods: In this interventional study; transtheoretical model, which is one of the cognitive-behavioral models was used for application of the peer education. Study was conducted in Izmir during 2011-2012 education period and included 338 students from 2 high schools The independent variable of the study is peer training.  Descriptive variables for a student are age, gender, tendecy of friends to smoke inside and outside the school,  the age they have first experienced the habit,  reasons for nicotine consumption,  levels of addiction,  chatting about smoking and related harms...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29331197/talking-about-the-impact-of-screen-viewing-on-health
#5
Isabelle Clavagnier
Emilia is a young woman admitted to the hospital for pyelonephritis. Sophie finds out, from the morning reports about her, that she stays awake very late every night watching television or chatting on her mobile phone.
January 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29327125/icariin-improves-cognitive-impairment-after-traumatic-brain-injury-by-enhancing-hippocampal-acetylation
#6
Zi-Gang Zhang, Xin Wang, Jin-Hai Zai, Cai-Hua Sun, Bing-Chun Yan
OBJECTIVE: To examine the effect of icariin (ICA) on the cognitive impairment induced by traumatic brain injury (TBI) in mice and the underlying mechanisms related to changes in hippocampal acetylation level. METHODS: The modifified free-fall method was used to establish the TBI mouse model. Mice with post-TBI cognitive impairment were randomly divided into 3 groups using the randomised block method (n=7): TBI (vehicle-treated), low-dose (75 mg/kg) and high-dose (150 mg/kg) of ICA groups...
January 9, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29319543/choline-acetyltransferase-and-trka-expression-as-well-as-the-improvement-in-cognition-produced-by-e2-and-p4-in-ovariectomized-rats-are-blocked-by-ici-182%C3%A2-780-and-ru486
#7
Judith Espinosa-Raya, Ulises Cruz-Raya, Margarita López-Martínez, Ofir Picazo
Treatment with 17-β estradiol and progesterone improves the performance of ovariectomized rats in an autoshaping learning task, representing cognitive improvement. To test whether this is attributable to genomic mechanisms, the antiestrogen ICI 182 780 or antiprogesterone RU486 was injected into ovariectomized animals primed previously with estrogen or progesterone, respectively. Compared with the vehicle control, each hormone administered alone produced an elevated expression of choline acetyltransferase and TrkA, along with an improvement in performance on the behavioral test...
January 9, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29317938/assessing-the-knowledge-to-practice-gap-the-asthma-practices-of-community-pharmacists
#8
Lisa M Guirguis
Background: Community pharmacists are well positioned to identify patients with poorly controlled asthma and trained to optimize asthma therapy. Yet, over 90% of patients with asthma live with uncontrolled disease. We sought to understand the current state of asthma management in practice in Alberta and explore the potential use of the Chat, Check and Chart (CCC) model to enhance pharmacists' care for patients with asthma. Methods: An 18-question survey was used to examine pharmacists' monitoring of asthma control and prior use of the CCC tools...
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29310965/evaluation-of-primary-angle-closure-glaucoma-susceptibility-loci-in-patients-with-early-stages-of-angle-closure-disease
#9
Monisha E Nongpiur, Ching-Yu Cheng, Roopam Duvesh, Saravanan Vijayan, Mani Baskaran, Chiea-Chuen Khor, John Allen, Srinivasan Kavitha, Rengaraj Venkatesh, David Goh, Rahat Husain, Pui Yi Boey, Desmond Quek, Ching Lin Ho, Tina T Wong, Shamira Perera, Tien Yin Wong, Subbiah R Krishnadas, Periasamy Sundaresan, Tin Aung, Eranga N Vithana
PURPOSE: To investigate whether newly identified genetic loci for primary angle-closure glaucoma (PACG) are associated with early stage angle-closure disease defined as primary angle closure suspect (PACS). DESIGN: Case-control study. PARTICIPANTS: A total of 1397 PACS patients and 943 controls of Chinese ethnicity from Singapore and 604 PACS patients and 287 controls of Indian ethnicity. METHODS: The 8 PACG single nucleotide polymorphisms (SNPs; rs11024102 at PLEKHA7, rs3753841 at COL11A1, rs1015213 located between PCMTD1 and ST18 son chromosome 8q, rs3816415 at EPDR1, rs1258267 at CHAT, rs736893 at GLIS3, rs7494379 at FERMT2, and rs3739821 mapping in between DPM2 and FAM102A) were genotyped by Taqman assays...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310534/prevalence-trends-and-consequences-of-substance-use-among-university-students-implication-for-intervention
#10
Meseret Ayalew, Mateb Tafere, Yohannes Asmare
This study was conducted to examine the prevalence, trends, and consequences of substance use among university students. The prevalence of substance use, the trends of substance use, and the differences among sociodemographic variables in the experiences of substance use as well as the consequences of substance use among university students were assessed in this study. Using stratified sampling method, 1,156 students were chosen. Descriptive statistics, chi-square, one-way analysis of variance, and Pearson correlation coefficient were used for data analysis...
January 1, 2018: International Quarterly of Community Health Education
https://www.readbyqxmd.com/read/29306372/twitter-journal-clubs-and-continuing-professional-development-an-analysis-of-a-medradjclub-tweet-chat
#11
A Bolderston, J Watson, N Woznitza, A Westerink, L Di Prospero, G Currie, C Beardmore, J Hewis
INTRODUCTION: Online Twitter journal clubs are a recent and popular innovation with the potential to increase research awareness and inform practice. The medical radiation sciences' MedRadJournalClub (MJRC) is a Twitter-based event that attracts a global group of participants at the monthly chats. An analysis of a recent MedRadJournalClub discussion evaluated the perceived benefits and limitations of medical radiation practitioners participating in an online journal club. METHODS: The February 2017 chat used for analysis was based on the Journal of Medical Imaging and Radiation Sciences article by Currie et al...
February 2018: Radiography
https://www.readbyqxmd.com/read/29306322/curcumin-attenuates-collagen-induced-inflammatory-response-through-the-gut-brain-axis
#12
Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan, Peng Zhao, Yufeng Xia, Huijuan Hu, Yue Dai
BACKGROUND: Previous studies have demonstrated that oral administration of curcumin exhibited an anti-arthritic effect despite its poor bioavailability. The present study aimed to explore whether the gut-brain axis is involved in the therapeutic effect of curcumin. METHODS: The collagen-induced arthritis (CIA) rat model was induced by immunization with an emulsion of collagen II and complete Freund's adjuvant. Sympathetic and parasympathetic tones were measured by electrocardiographic recordings...
January 6, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29306218/toddlers-at-risk-for-autism-spectrum-disorders-from-kerala-india-a-community-based-screening
#13
Jaisoorya Ts, Preeti Jacob, Shoba Srinath, Sunil Kumar G, Manoj L, Gokul Gr, Diana L Robins, Thennarasu K
AIMS: To study the at-risk rate for Autism Spectrum Disorders (ASD) on a parent-report questionnaire in toddlers between the ages of 16-24 months. MATERIALS AND METHODS: 6237 toddlers from Kerala, India selected by cluster random sampling were surveyed by community nurses using the Modified Checklist for Autism in Toddlers - Revised (M-CHAT-R) translated to Malayalam and culturally adapted. RESULTS: 5.5% toddlers were at risk on M-CHAT-R and 2...
December 28, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29299689/segmental-differences-in-the-non-neuronal-cholinergic-system-in-rat-caecum
#14
Sandra Bader, Martin Diener
Acetylcholine is not only a neurotransmitter but is also produced by several non-neuronal cell types with barrier or defence function. One of the non-neuronal tissues with expression of the key enzyme for production of acetylcholine, the choline acetyltransferase (ChAT), is the colonic surface epithelium, which releases acetylcholine after contact with the short-chain fatty acid propionate produced physiologically in the colonic lumen during the microbial fermentation of carbohydrates. Despite the fact that the caecum is the largest fermentation chamber in non-ruminant mammals, nothing is known about the expression and function of a non-neuronal cholinergic system in this part of the large intestine, which was addressed in the present study...
January 3, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29297566/immunohistochemical-characteristics-of-neurons-in-the-ganglia-of-the-greater-splanchnic-nerve-of-the-pig
#15
Jamal Nourinezhad, Piotr Podlasz, Krzysztof Wasowicz
INTRODUCTION: Greater splanchnic nerve (GSN) is by far the largest of the splanchnic nerves and connects the paravertebral and prevertebral ganglia to transmit the majority of nociceptive information from the viscera. Despite its importance, the immunohistochemical features of the porcine GSN neurons have not yet been examined. Therefore, the aim of the study was to investigate the neurochemistry of the porcine GSN neurons and to compare their neurochemical coding with those of the paravertebral and prevertebral ganglia...
January 3, 2018: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/29288022/variable-expression-of-gfp-in-different-populations-of-peripheral-cholinergic-neurons-of-chatbac-egfp-transgenic-mice
#16
T Christopher Brown, Cherie E Bond, Donald B Hoover
Immunohistochemistry is used widely to identify cholinergic neurons, but this approach has some limitations. To address these problems, investigators developed transgenic mice that express enhanced green fluorescent protein (GFP) directed by the promoter for choline acetyltransferase (ChAT), the acetylcholine synthetic enzyme. Although, it was reported that these mice express GFP in all cholinergic neurons and non-neuronal cholinergic cells, we could not detect GFP in cardiac cholinergic nerves in preliminary experiments...
December 20, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29273661/design-and-rationale-of-the-cardiovascular-health-and-text-messaging-chat-study-and-the-chat-diabetes-mellitus-chat-dm-study-two-randomised-controlled-trials-of-text-messaging-to-improve-secondary-prevention-for-coronary-heart-disease-and-diabetes
#17
Xiqian Huo, Erica S Spatz, Qinglan Ding, Paul Horak, Xin Zheng, Claire Masters, Haibo Zhang, Melinda L Irwin, Xiaofang Yan, Wenchi Guan, Jing Li, Xi Li, John A Spertus, Frederick A Masoudi, Harlan M Krumholz, Lixin Jiang
INTRODUCTION: Mobile health interventions have the potential to promote risk factor management and lifestyle modification, and are a particularly attractive approach for scaling across healthcare systems with limited resources. We are conducting two randomised trials to evaluate the efficacy of text message-based health messages in improving secondary coronary heart disease (CHD) prevention among patients with or without diabetes. METHODS AND ANALYSIS: The Cardiovascular Health And Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study are multicentre, single-blind, randomised controlled trials of text messaging versus standard treatment with 6 months of follow-up conducted in 37 hospitals throughout 17 provinces in China...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29247642/nature-to-the-natural-rescue-silencing-microbial-chats
#18
REVIEW
Diby Paul, Judy Gopal, Manish Kumar, Muthu Manikandan
Communication is the sole means by which effective networking and co-existence is accomplished amongst living beings. Microbes have their own chit-chats. Science has overheard these microbial gossips and have concluded that these aren't just informal communications, but carefully coordinated signals that plan their effective strategies. Tracking one such signal molecule, N-acyl homoserine lactone (AHL), led to a fundamental understanding to microbial quorum sensing (QS). Furtherance of research sought for ways to cut off communication between these virulent forms, so as to hinder their combinatorial attacks through quorum sensing inhibitors (QSIs)...
December 14, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29241675/effect-of-telmisartan-on-preventing-learning-and-memory-deficits-via-peroxisome-proliferator-activated-receptor-%C3%AE-in-vascular-dementia-spontaneously-hypertensive-rats
#19
Yuan Gao, Wei Li, Yali Liu, Yan Wang, Jianchao Zhang, Miao Li, Mengsen Bu
BACKGROUND: This study aimed to explore the effect of telmisartan (TEL), as a partial peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, in vascular dementia (VaD) rats induced by middle cerebral artery occlusion (MCAO). METHODS: Spontaneously hypertensive rats were divided into 6 groups: the sham group, model group, TEL-treated groups (1, 5, and 10 mg/kg), and TEL + GW9662 (10 mg/kg + 1 mg/kg). Using the MCAO method established the VaD rat model...
December 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29237193/-attendance-for-using-internet-based-support-after-inpatient-treatment-a-cross-sectional-survey
#20
Fabian Frank, Nicola Gräder, Hannah Dahlmann, Mathias Berger, Lars Hölzel
Objective Examination of the attendance for using internet-based measures after inpatient treatment. Methods Cross-sectional-survey in former inpatients (N = 247). Results 44.9 % are willing to use measures via videoconference, 34.7 % via Chat, 50.0 % via E-Mail and 38.0 % as onlinetherapy. Attendance is lower in older age groups. Benefits regarding the introduced measures are seen mainly in the flexibility and disadvantages in the impersonal character. Conclusions A relevant share of especially younger patients is willing to use internet-based measures...
December 13, 2017: Psychiatrische Praxis
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