keyword
MENU ▼
Read by QxMD icon Read
search

ChAT

keyword
https://www.readbyqxmd.com/read/28936493/modeling-dialogue-acts-with-content-word-filtering-and-speaker-preferences
#1
Yohan Jo, Michael Miller Yoder, Hyeju Jang, Carolyn P Rosé
We present an unsupervised model of dialogue act sequences in conversation. By modeling topical themes as transitioning more slowly than dialogue acts in conversation, our model de-emphasizes content-related words in order to focus on conversational function words that signal dialogue acts. We also incorporate speaker tendencies to use some acts more than others as an additional predictor of dialogue act prevalence beyond temporal dependencies. According to the evaluation presented on two dissimilar corpora, the CNET forum and NPS Chat corpus, the effectiveness of each modeling assumption is found to vary depending on characteristics of the data...
September 2017: Proceedings of the Conference on Empirical Methods in Natural Language Processing. Conference on Empirical Methods in Natural Language Processing
https://www.readbyqxmd.com/read/28932225/expression-and-function-of-the-cholinergic-system-in-immune-cells
#2
REVIEW
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima
T and B cells express most cholinergic system components-e.g., acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively). Using ChAT(BAC)-eGFP transgenic mice, ChAT expression has been confirmed in T and B cells, dendritic cells, and macrophages. Moreover, T cell activation via T-cell receptor/CD3-mediated pathways upregulates ChAT mRNA expression and ACh synthesis, suggesting that this lymphocytic cholinergic system contributes to the regulation of immune function...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28931726/impaired-insulin-igf-1-is-responsible-for-diabetic-gastroparesis-by-damaging-myenteric-cholinergic-neurons-and-interstitial-cells-of-cajal
#3
Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou
Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment but not glycemic control potently accelerated gastric emptying in type 1 DM patients, the role of insulin/InsR and IGF-1/IGF-1R signaling in diabetic gastroparesis remains incompletely elucidated. In this study, type 1 DM mice were established and treated with insulin or Voglibose for 8 weeks. The gastric emptying was delayed from DM week 4 when the gastric InsR and IGF-1R were declined...
September 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28921689/associations-between-eating-disorder-related-symptoms-and-participants-utilization-of-an-individualized-internet-based-prevention-and-early-intervention-program
#4
Sally Kindermann, Markus Moessner, Fikret Ozer, Stephanie Bauer
OBJECTIVE: Flexible, individualized interventions allow participants to adjust the intensity of support to their current needs. Between-persons, participants with greater needs can receive more intense support, within-persons, participants can adjust utilization to their current level of symptoms. The purpose of the present study was to analyze associations between ED-related symptoms and utilization of the individualized program ProYouth both between- and within-persons, aiming to investigate whether participants adapt utilization intensity to their current needs...
September 18, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28919466/intrastriatally-injected-botulinum-neurotoxin-a-differently-effects-cholinergic-and-dopaminergic-fibers-in-c57bl-6-mice
#5
Alexander Hawlitschka, Carsten Holzmann, Sarah Witt, Juliane Spiewok, Anne-Marie Neumann, Oliver Schmitt, Andreas Wree, Veronica Antipova
Unilateral intrastriatal BoNT-A injection abolished apomorphine-induced rotational behavior in a rat model of hemiparkinsonism (hemi-PD) up to 6 months. It was hypothesized that the beneficial effect of botulinum neurotoxin-A (BoNT-A) grounded on the reduction of the Parkinson's diseases (PD) associated striatal hypercholinism. Intrastriatal injection of BoNT-A was not cytotoxic in rat brain, but neuronal fiber swellings in the BoNT-A infiltrated striata appeared and named BoNT-A-induced varicosities (BiVs)...
September 14, 2017: Brain Research
https://www.readbyqxmd.com/read/28918392/cnvs-affecting-cancer-predisposing-genes-cpgs-detected-as-incidental-findings-in-routine-germline-diagnostic-chromosomal-microarray-cma-testing
#6
Josie Innes, Lisa Reali, Jill Clayton-Smith, Georgina Hall, Derek Hk Lim, George J Burghel, Kim French, Unzela Khan, Daniel Walker, Fiona Lalloo, D Gareth R Evans, Dominic McMullan, Eamonn R Maher, Emma R Woodward
BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line investigation in individuals with learning difficulties/congenital abnormalities. Although recognised that CMA testing may identify CNVs encompassing a cancer predisposition gene (CPG), limited information is available on the frequency and nature of such results. METHODS: We investigated CNV gains and losses affecting 39 CPGs in 3366 pilot index case individuals undergoing CMA testing, and then studied an extended cohort (n=10 454) for CNV losses at 105 CPGs and CNV gains at 9 proto-oncogenes implicated in inherited cancer susceptibility...
September 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28910337/mouse-repeated-electroconvulsive-seizure-ecs-does-not-reverse-social-stress-effects-but-does-induce-behavioral-and-hippocampal-changes-relevant-to-electroconvulsive-therapy-ect-side-effects-in-the-treatment-of-depression
#7
Erin M van Buel, Hannes Sigrist, Erich Seifritz, Lianne Fikse, Fokko J Bosker, Robert A Schoevers, Hans C Klein, Christopher R Pryce, Ulrich Lm Eisel
Electroconvulsive therapy (ECT) is an effective treatment for depression, but can have negative side effects including amnesia. The mechanisms of action underlying both the antidepressant and side effects of ECT are not well understood. An equivalent manipulation that is conducted in experimental animals is electroconvulsive seizure (ECS). Rodent studies have provided valuable insights into potential mechanisms underlying the antidepressant and side effects of ECT. However, relatively few studies have investigated the effects of ECS in animal models with a depression-relevant manipulation such as chronic stress...
2017: PloS One
https://www.readbyqxmd.com/read/28902399/using-the-contextual-hub-analysis-tool-chat-in-cytoscape-to-identify-contextually-relevant-network-hubs
#8
Tanja Muetze, David J Lynn
Highly connected nodes in biological networks are called network hubs. Hubs are topologically important to the structure of the network and have been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we provide a step-by-step protocol for using the Contextual Hub Analysis Tool (CHAT), an application within Cytoscape 3, which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene or protein expression data, and identify hub nodes that are more highly connected to contextual nodes than expected by chance...
September 13, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28901737/melatonin-improves-cognitive-deficits-via-restoration-of-cholinergic-dysfunction-in-a-mouse-model-of-scopolamine-induced-amnesia
#9
Bai Hui Chen, Joon Ha Park, Dae Won Kim, Jinseu Park, Soo Young Choi, In Hye Kim, Jeong Hwi Cho, Tae-Kyeong Lee, Jae Chul Lee, Choong-Hyun Lee, In Koo Hwang, Young-Myeong Kim, Bing Chun Yan, Il-Jun Kang, Bich Na Shin, Yun Lyul Lee, Myoung Cheol Shin, Jun Hwi Cho, Young Joo Lee, Yong Hwan Jeon, Moo-Ho Won, Ji Hyeon Ahn
Melatonin is known to improve cognitive deficits and its functions have been studied in various disease models, including Alzheimer's disease. In this study, we investigated effects of melatonin on cognition and the cholinergic system of the septum and hippocampus in a mouse model of scopolamine-induced amnesia. Scopolamine (1 mg/kg) and melatonin (10 mg/kg) were administered intraperitoneally to mice for 2 and 4 weeks. The Morris water maze and passive avoidance tests revealed that both treatments of scopolamine significantly impaired spatial learning and memory; however, 2- and 4-week melatonin treatments significantly improved the spatial learning and memory...
September 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28884834/transplantation-of-hypoxic-preconditioned-neural-stem-cells-benefits-functional-recovery-via-enhancing-neurotrophic-secretion-after-spinal-cord-injury-in-rats
#10
Wei-Li Fan, Peng Liu, Guan Wang, Jung-Ang Pu, Xin Xue, Jian-Hua Zhao
Spinal cord injury (SCI) is a debilitating, costly, and common pathological condition that affects the function of central nervous system (CNS). To date, there are few promising therapeutic strategies available for SCI. To look for a suitable therapeutic strategy, we have developed a sublethal hypoxic preconditioning procedure using Fluorescence-activated cell sorting (FACS) analysis, LDH releasing and cell viability assays in vitro. Meanwhile, we have examined the benefits of neural stem cells (NSCs) transplantation prior to hypoxic preconditioning on functional recovery and potential mechanism via MRI screening, H&E and Nissl staining, immunofluorescence staining and Elisa assays...
September 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28877213/ostracism-via-virtual-chat-room-effects-on-basic-needs-anger-and-pain
#11
Ana Paula Gonçalves Donate, Lucas Murrins Marques, Olivia Morgan Lapenta, Manish Kumar Asthana, David Amodio, Paulo Sérgio Boggio
Ostracism is characterized by a social pain provoked by being excluded and ignored. In order to address the effects of social ostracism in virtual non-physical interactions, we developed a more realistic paradigm as an alternative to Cyberball and assessed its effects on participant's expression of basic social needs, emotional experience and painful feeling. The chat room consisted of controlled social dialogue interactions between participants and two other (confederate) chat room partners. Exclusion was manipulated by varying the number of messages a participant received (15% and 33% in exclusion and inclusion, respectively)...
2017: PloS One
https://www.readbyqxmd.com/read/28875613/risk-factors-for-smartphone-addiction-in-korean-adolescents-smartphone-use-patterns
#12
Hyuk Lee, Jun Won Kim, Tae Young Choi
With widespread use of the smartphone, clinical evidence for smartphone addiction remains unclear. Against this background, we analyzed the effect of smartphone use patterns on smartphone addiction in Korean adolescents. A total of 370 middle school students participated. The severity of smartphone addiction was measured through clinical interviews and the Korean Smartphone Addiction Proneness Scale. As a result, 50 (13.5%) were in the smartphone addiction group and 320 (86.5%) were in the healthy group. To investigate the effect of smartphone use patterns on smartphone addiction, we performed self-report questionnaires that assessed the following items: smartphone functions mostly used, purpose of use, problematic use, and parental attitude regarding smartphone use...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28874448/glycinergic-input-to-the-mouse-basal-forebrain-cholinergic-neurons
#13
Zsuzsanna Bardóczi, Balázs Pál, Áron Kőszeghy, Tamás Wilheim, Masahiko Watanabe, László Záborszky, Zsolt Liposits, Imre Kalló
The basal forebrain (BF) receives afferents from brain stem ascending pathways, which has been implicated first by Moruzzi and Magoun (Moruzzi and Magoun, 1949) to induce forebrain activation and cortical arousal/waking behavior; however, it is very little known about how brain stem inhibitory inputs affect cholinergic functions. In the current study, glycine, a major inhibitory neurotransmitter of brain stem neurons, and gliotransmitter of local glial cells, was tested for potential interaction with basal forebrain cholinergic (BFC) neurons in male mice...
September 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28873419/gender-and-autistic-traits-modulate-implicit-motor-synchrony
#14
Miao Cheng, Masaharu Kato, Chia-Huei Tseng
Interpersonal motor synchrony during walking or dancing is universally observed across cultures, and this joint movement was modulated by physical and social parameters. However, human interactions are greatly shaped by our unique traits, and self-related factors are surprisingly little studied in the context of interpersonal motor synchrony. In this study, we investigated two such factors known to be highly associated with motor coordination: gender and autistic traits. We employed a real-world task extending our understanding beyond laboratory tasks...
2017: PloS One
https://www.readbyqxmd.com/read/28868184/multiple-endocrine-neoplasia-2b-differential-increase-in-enteric-nerve-subgroups-in-muscle-and-mucosa
#15
John M Hutson, Pam J Farmer, Cristal J Peck, Chung W Chow, Bridget R Southwell
Multiple endocrine neoplasia 2B (MEN2B) is a rare syndrome caused by an activating mutation of the RET gene, leading to enteric gangliomatosis. This child presented with constipation at 1-mo old, was diagnosed with MEN2B by rectal biopsy at 4 mo, had thyroidectomy at 9 mo and a colectomy at 4 years. We studied the extent of neuronal and nerve fibre proliferation and which classes of enteric nerves are affected by examining the colon with multiple neuronal antibodies. Resected transverse colon was fixed, frozen, sectioned and processed for fluorescence immunohistochemistry labelling with antibodies against TUJ1, Hu, ChAT, NOS, VIP, SP and CGRP and cKit...
August 15, 2017: World Journal of Gastrointestinal Pathophysiology
https://www.readbyqxmd.com/read/28867578/streptozotocin-induced-hippocampal-astrogliosis-and-insulin-signaling-malfunction-as-experimental-scales-for-subclinical-sporadic-alzheimer-model
#16
Farzaneh Rostami, Mohammad Javan, Ali Moghimi, Aliakbar Haddad-Mashadrizeh, Masoud Fereidoni
AIMS: Insulin signaling malfunction has recently been suggested as a preliminary event involved in the etiology of Sporadic Alzheimer's disease (SAD). In order to develop insulin resistance-related SAD model, rats were treated with streptozotocin, intracerebroventricularly (icv-STZ). Nevertheless, given the lack of knowledge regarding sub-clinical stages of SAD, the current challenging issue is establishing a practical pre-clinical SAD model. Despite some proposed mechanisms, such as insulin malfunction, neuroinflammation, and gliosis, icv-STZ mechanism of action is not fully understood yet and Streptozotocin-induced rat model of Alzheimer has still major shortcomings...
August 31, 2017: Life Sciences
https://www.readbyqxmd.com/read/28866856/accuracy-of-modified-checklist-for-autism-in-toddlers-m-chat-in-detecting-autism-and-other-developmental-disorders-in-community-clinics
#17
Teck-Hock Toh, Vivian Wee-Yen Tan, Peter Sie-Teck Lau, Andrew Kiyu
This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15-36 months) who had M-CHAT performed in 2006-2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27-36-month age cohorts (54.5-64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81...
September 2, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28864427/social-media-for-the-dissemination-of-cochrane-child-health-evidence-evaluation-study
#18
Michele P Dyson, Amanda S Newton, Kassi Shave, Robin M Featherstone, Denise Thomson, Aireen Wingert, Ricardo M Fernandes, Lisa Hartling
BACKGROUND: Health care providers value ready access to reliable synthesized information to support point-of-care decision making. Web-based communities, facilitated by the adoption of social media tools such as Facebook, Twitter, and YouTube, are increasingly being used for knowledge dissemination, bridging the gap between knowledge generation and synthesis and knowledge implementation. OBJECTIVE: Our objective was to implement and evaluate a structured social media strategy, using multiple platforms, to disseminate Cochrane Child Health evidence to health care providers caring for children...
September 1, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28837980/-chances-and-risks-of-telemedicine-in-orthopaedics-and-trauma-surgery
#19
Martin Holderried, Madeleine Schlipf, Ansgar Höper, Reinhard Meier, Ulrich Stöckle, Tobias Maximilian Kraus
Background The use of information technology (IT) in health care has continuously increased. This includes software solutions for digitalisation, data storage and innovative approaches in diagnostics. The facilitation of the access to specific information, even by the patient, has changed daily clinical work. Patients inform themselves about symptoms, diagnostic methods and treatment options. This urge for information and the wish for the best treatment is summarised in the expression "patient empowerment"...
August 24, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28836741/quantification-and-neurochemical-coding-of-the-myenteric-plexus-in-humans-no-regional-variation-between-the-distal-colon-and-rectum
#20
K-S Ng, N A Montes-Adrian, D A Mahns, M A Gladman
BACKGROUND: It remains unclear whether regional variation exists in the human enteric nervous system (ENS) ie, whether intrinsic innervation varies along the gut. Recent classification of gastrointestinal neuropathies has highlighted inadequacies in the quantification of the human ENS. This study used paired wholemounts to accurately quantify and neurochemically code the hindgut myenteric plexus, comparing human distal colon and rectum. METHODS: Paired human descending colonic/rectal specimens were procured from 15 patients undergoing anterior resection...
August 24, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
keyword
keyword
47756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"