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https://www.readbyqxmd.com/read/28642718/irinotecan-induced-gastrointestinal-dysfunction-is-associated-with-enteric-neuropathy-but-increased-numbers-of-cholinergic-myenteric-neurons
#1
Rachel M McQuade, Vanesa Stojanovska, Elizabeth L Donald, Ahmed A Rahman, Dean G Campelj, Raquel Abalo, Emma Rybalka, Joel C Bornstein, Kulmira Nurgali
Gastrointestinal dysfunction is a common side-effect of chemotherapy leading to dose reductions and treatment delays. These side-effects may persist up to 10 years post-treatment. A topoisomerase I inhibitor, irinotecan (IRI), commonly used for the treatment of colorectal cancer, is associated with severe acute and delayed-onset diarrhea. The long-term effects of IRI may be due to damage to enteric neurons innervating the gastrointestinal tract and controlling its functions. Balb/c mice received intraperitoneal injections of IRI (30 mg/kg(-1)) 3 times a week for 14 days, sham-treated mice received sterile water (vehicle) injections...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28642215/what-motivates-young-adults-to-talk-about-physical-activity-on-social-network-sites
#2
Ni Zhang, Shelly Campo, Jingzhen Yang, Petya Eckler, Linda Snetselaar, Kathleen Janz, Emily Leary
BACKGROUND: Electronic word-of-mouth on social network sites has been used successfully in marketing. In social marketing, electronic word-of-mouth about products as health behaviors has the potential to be more effective and reach more young adults than health education through traditional mass media. However, little is known about what motivates people to actively initiate electronic word-of-mouth about health behaviors on their personal pages or profiles on social network sites, thus potentially reaching all their contacts on those sites...
June 22, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28638520/the-consultant-chat-a-novel-didactic-method-for-specialist-presentations-to-emergency-medicine-residents
#3
Richard Bounds, Jenna Fredette
No abstract text is available yet for this article.
June 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28634734/exploring-the-digital-technology-preferences-of-teenagers-and-young-adults-tya-with-cancer-and-survivors-a-cross-sectional-service-evaluation-questionnaire
#4
Esha Abrol, Mike Groszmann, Alexandra Pitman, Rachael Hough, Rachel M Taylor, Golnar Aref-Adib
PURPOSE: Digital technology has the potential to support teenagers and young adults (TYAs) with cancer from the onset of their disease into survivorship. We aimed to establish (1) the current pattern of use of TYA digital technologies within our service-user population, and (2) their preferences regarding digital information and support within the service. METHODS: A cross-sectional survey was administered as a paper and online self-completed questionnaire to TYAs aged 13-24 accessing outpatient, inpatient, and day care cancer services at a regional specialist centre over a 4-week period...
June 20, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28632981/baccn-twitter-chats
#5
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28628197/vesicular-acetylcholine-transporter-vacht-overexpression-induces-major-modifications-of-striatal-cholinergic-interneuron-morphology-and-function
#6
Helena Janickova, Vania F Prado, Marco A M Prado, Salah El Mestikawy, Véronique Bernard
Striatal cholinergic interneurons (CIN) are pivotal for the regulation of the striatal network. Acetylcholine (ACh) released by CIN is centrally involved in reward behavior as well as locomotor or cognitive functions. Recently, BAC transgenic mice expressing channelrhodopsin-2 (ChR2) protein under the control of the choline acetyltransferase (ChAT) promoter (ChAT-ChR2) and displaying almost 50 extra copies of the VAChT gene were used to dissect cholinergic circuit connectivity and function using optogenetic approaches...
June 19, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28627938/-i-ve-got-somebody-there-someone-cares-what-support-is-most-valued-following-a-stroke
#7
Sarah Northcott, Katerina Hilari
PURPOSE: There is often a need for increased support following a stroke. This study explored what types of support are provided by different network members and what support functions are most valued. METHODS: Adults with first stroke were recruited from a stroke unit and participated in in-depth interviews 8-15 months poststroke. Framework Analysis was used to build thematic and explanatory accounts of the data. RESULTS: Twenty-nine participants took part...
June 19, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28623224/ten-minute-chat
#8
(no author information available yet)
Claire explains more about what being an Army Reservist means.
June 17, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28618419/addictive-potential-of-internet-applications-and-differential-correlates-of-problematic-use-in-internet-gamers-versus-generalized-internet-users-in-a-representative-sample-of-adolescents
#9
Tabea Rosenkranz, Kai W Müller, Michael Dreier, Manfred E Beutel, Klaus Wölfling
AIMS: This paper examines the addictive potential of 8 different Internet applications, distinguishing male and female users. Moreover, differential correlates of problematic use are investigated in Internet gamers (IG) and generalized Internet users (GIU). METHOD: In a representative sample of 5,667 adolescents aged 12-19 years, use of Internet applications, problematic Internet use, psychopathologic symptoms (emotional problems, hyperactivity/inattention, and psychosomatic complaints), personality (conscientiousness and extraversion), psychosocial correlates (perceived stress and self-efficacy), and coping strategies were assessed...
June 16, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28609206/predicting-recidivism-among-internet-child-sex-sting-offenders-using-psychological-language-analysis
#10
Michelle Drouin, Ryan L Boyd, Miriam Greidanus Romaneli
In this study, we examined the extent to which computerized linguistic analysis of natural language data from chat transcripts of Internet child sex stings predicted recidivism among 334 convicted offenders. Using the Linguistic Inquiry and Word Count (LIWC) program, we found that reoffenders (including simultaneous and previous offenders) differed significantly from nonreoffenders in measures of clout (a composite measure of social dominance) and percentage of words used in the following linguistic categories: cognitive processes, personal pronoun use, insight, time, and ingestion...
June 13, 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28606208/medical-requirements-during-a-natural-disaster-a-case-study-on-whatsapp-chats-among-medical-personnel-during-the-2015-nepal-earthquake
#11
Moumita Basu, Saptarshi Ghosh, Arnab Jana, Somprakash Bandyopadhyay, Ravikant Singh
OBJECTIVE: The objective of this study was to explore a log of WhatsApp messages exchanged among members of the health care group Doctors For You (DFY) while they were providing medical relief in the aftermath of the Nepal earthquake in April 2015. Our motivation was to identify medical resource requirements during a disaster in order to help government agencies and other responding organizations to be better prepared in any upcoming disaster. METHODS: A large set of WhatsApp (WhatsApp Inc, Mountain View, CA) messages exchanged among DFY members during the Nepal earthquake was collected and analyzed to identify the medical resource requirements during different phases of relief operations...
June 13, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28604968/-prenatal-diagnosis-of-a-fetus-with-5p15-33-microdeletion
#12
Xueping Shen, Pingya He, Rong Fang, Juan Yao, Wenwen Li
OBJECTIVE: To screen for genomic copy number variants (CNVs) in a fetus with one sibling affected with Prader-Willi syndrome using single nucleotide polymorphism (SNP) array. METHODS: The fetus and its parents were subjected to chromosomal karyotyping and SNP array analysis. RESULTS: A 5p15.33 microdeletions was identified in the fetus and its phenotypically normal mother with a size of 344 kb (113 576 to 457 213). The father was normal for both testing...
June 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28604030/chatting-in-the-face-of-the-eyewitness-the-impact-of-extraneous-cell-phone-conversation-on-memory-for-a-perpetrator
#13
John E Marsh, Krupali Patel, Katherine Labonté, Emma Threadgold, Faye C Skelton, Cristina Fodarella, Rachel Thorley, Kirsty L Battersby, Charlie D Frowd, Linden J Ball, François Vachon
Cell-phone conversation is ubiquitous within public spaces. The current study investigates whether ignored cell-phone conversation impairs eyewitness memory for a perpetrator. Participants viewed a video of a staged crime in the presence of 1 side of a comprehensible cell-phone conversation (meaningful halfalogue), 2 sides of a comprehensible cell-phone conversation (meaningful dialogue), 1 side of an incomprehensible cell-phone conversation (meaningless halfalogue), or quiet. Between 24 and 28 hr later, participants freely described the perpetrator's face, constructed a single composite image of the perpetrator from memory, and attempted to identify the perpetrator from a sequential lineup...
June 12, 2017: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
https://www.readbyqxmd.com/read/28598580/neuroanatomy-of-the-pig-cardiac-ventricles-a-stereomicroscopic-confocal-and-electron-microscope-study
#14
Neringa Pauziene, Kristina Rysevaite-Kyguoliene, Paulius Alaburda, Audrys G Pauza, Monika Skukauskaite, Aiste Masaityte, Goda Laucaityte, Inga Saburkina, Hermanas Inokaitis, Jurgita Plisiene, Dainius H Pauza
Although the pig is a model for heart disease, the neuroanatomy of cardiac ventricles (CV) in this species remains undetailed. We aimed to define the innervation pattern of pig CV, combining histochemistry for acetylcholinesterase, immunofluorescent labeling and electron microscopy. Forty nine examined pig hearts show that the major nerves supplying the ventral side of CV descend from the venous part of the heart hilum. Fewer in number and smaller in size, epicardial nerves supply the dorsal half of the CV...
June 9, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28596149/measuring-audience-engagement-for-public-health-twitter-chats-insights-from-livefitnola
#15
Kristina M Rabarison, Merriah A Croston, Naomi K Englar, Connie L Bish, Shelbi M Flynn, Carolyn C Johnson
BACKGROUND: Little empirical evidence exists on the effectiveness of using Twitter as a two-way communication tool for public health practice, such as Twitter chats. OBJECTIVE: We analyzed whether Twitter chats facilitate engagement in two-way communications between public health entities and their audience. We also describe how to measure two-way communications, incoming and outgoing mentions, between users in a protocol using free and publicly available tools (Symplur, OpenRefine, and Gephi)...
June 8, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28592359/mercury-accumulation-in-lethrinus-nebulosus-from-the-marine-waters-of-the-qatar-eez
#16
Ebrahim M A S Al-Ansari, Mohamed A R Abdel-Moati, Oguz Yigiterhan, Ibrahim Al-Maslamani, Yousria Soliman, Gilbert T Rowe, Terry L Wade, Ismail M Al-Shaikh, Ahmed Helmi, Ligita Kuklyte, Mark Chatting, Mehsin A Al-Ansi Al-Yafei
Total mercury (THg) and methylmercury (MeHg) were recorded in the commercial demersal fish Lethrinus nebulosus, caught from six locations in Qatar EEZ (Exclusive Economic Zone). Concentrations of THg decreased in the order: liver˃muscle˃gonad. THg concentrations in fish tissue ranged from 0.016ppm in gonad to 0.855ppm (mgkg(-1)w/w) in liver tissues, while concentrations in muscle tissue ranged from 0.24 to 0.49ppm (mgkg(-1)w/w) among sampling sites. MeHg concentrations were used to validate food web transfer rate calculations...
June 4, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28587479/using-wechat-online-social-networking-in-a-real-world-needs-analysis-of-family-members-of-youths-at-clinical-high-risk-of-psychosis
#17
TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, HuiJun Li, YanYan Wei, YangYang Xu, LiJuan Jiang, YiKang Zhu, ChunBo Li, KaiDa Jiang, ZePing Xiao, JiJun Wang
OBJECTIVE: The argument surrounding the safety and effectiveness of interventions for the population of individuals at a clinical high risk of developing psychosis has been ongoing for the past 30 years. However, few studies have assessed the needs of this special young population, who are struggling with the recent onset of psychotic symptoms. METHOD: The sample consisted of 171 family members of 108 clinical high-risk individuals included from the ShangHai at Risk for Psychosis research programme...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28576941/reduced-slc6a15-in-nucleus-accumbens-d2-neurons-underlies-stress-susceptibility
#18
Ramesh Chandra, T Chase Francis, Hyungwoo Nam, Lace M Riggs, Michel Engeln, Sarah Rudzinskas, Prasad Konkalmatt, Scott J Russo, Gustavo Turecki, Sergio Iniguez, Mary Kay Lobo
Previous research demonstrates that Slc6a15, a neutral amino acid transporter, is associated with depression susceptibility. However, no study examined Slc6a15 in the ventral striatum (nucleus accumbens, NAc) in depression. Given our previous characterization of Slc6a15 as a striatal dopamine-receptor-2 (D2)-neuron enriched gene, we examined the role of Slc6a15 in NAc D2-neurons in mediating susceptibility to stress in male mice. First, we showed that Slc6a15 mRNA was reduced in NAc of mice susceptible to chronic social defeat stress (CSDS), a paradigm that produces behavioral and molecular adaptations that resemble clinical depression...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28573828/social-support-in-chat-sessions-for-adolescents-and-young-adults-living-with-a-family-member-with-mental-illness
#19
Louisa M Drost, Lian van der Krieke, Zamira Iedema-den Boer, Sjoerd Sytema, Gerard M Schippers
Children from families with a mental illness are at risk of developing negative health outcomes. Online interventions are a new way to offer support to these children. The present study utilized a website that had been developed to support Dutch youth who had a family member with a mental illness. The objective was to analyse monitored and unmonitored chatroom conversations among these young people, and specifically to compare supportive messages and self-disclosures of experiences. We electronically imported session transcripts of 34 chatroom conversations into the qualitative analysis software Atlas...
June 1, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28570646/diurnal-fluctuation-in-the-number-of-hypocretin-orexin-and-histamine-producing-implication-for-understanding-and-treating-neuronal-loss
#20
Ronald McGregor, Ling Shan, Ming-Fung Wu, Jerome M Siegel
The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified using this method misses a substantial percentage of extant neurons in a phenotype specific manner. In mice, 24% more hypocretin/orexin (Hcrt) neurons are seen in the night compared to the day, and an additional 17% are seen after inhibiting microtubule polymerization with colchicine...
2017: PloS One
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