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PTP4A3

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https://www.readbyqxmd.com/read/27901069/molecular-profiling-of-circulating-tumour-cells-identifies-notch1-as-a-principal-regulator-in-advanced-non-small-cell-lung-cancer
#1
Javier Mariscal, Marta Alonso-Nocelo, Laura Muinelo-Romay, Jorge Barbazan, Maria Vieito, Alicia Abalo, Antonio Gomez-Tato, Casares de Cal Maria de Los Angeles, Tomas Garcia-Caballero, Carmela Rodriguez, Elena Brozos, Francisco Baron, Rafael Lopez-Lopez, Miguel Abal
Knowledge on the molecular mechanisms underlying metastasis colonization in Non-Small Cell Lung Cancer (NSCLC) remains incomplete. A complete overview integrating driver mutations, primary tumour heterogeneity and overt metastasis lacks the dynamic contribution of disseminating metastatic cells due to the inaccessibility to the molecular profiling of Circulating Tumour Cells (CTCs). By combining immunoisolation and whole genome amplification, we performed a global gene expression analysis of EpCAM positive CTCs from advanced NSCLC patients...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876019/a-systematic-comparison-of-copy-number-alterations-in-four-types-of-female-cancer
#2
Fatemeh Kaveh, Lars O Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N Kristensen, Hiroko K Solvang
BACKGROUND: Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, different female, hormone-dependent cancers to identify common and diverse DNA aberrations, genes, and pathways. METHODS: In this work, we analyzed tissue samples from patients with breast (n = 112), ovarian (n = 74), endometrial (n = 84), or cervical (n = 76) cancer...
November 22, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27698077/src-family-kinases-are-regulated-in-multiple-myeloma-cells-by-phosphatase-of-regenerating-liver-3
#3
Pegah Abdollahi, Esten Nymoen Vandsemb, Magnus Aassved Hjort, Kristine Misund, Toril Holien, Anne-Marit Sponaas, Torstein B Ro, Tobias S Slordahl, Magne Borset
: Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual specificity phosphatase that is up-regulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of PRL-3 is elevated in response to several anti-apoptotic cytokines, including interleukin-6 (IL6), in cancer cells from patients with multiple myeloma (MM) and can promote survival and migration. Here it is demonstrated that PRL-3 activates Src kinase in the IL6-dependent MM cell line INA-6...
October 3, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27588115/prl-3-promotes-cell-adhesion-by-interacting-with-jam2-in-colon-cancer
#4
Shenyi Lian, Lin Meng, Xiaofang Xing, Yongyong Yang, Like Qu, Chengchao Shou
Phosphatase of regenerating liver-3 (PRL-3), also termed PTP4A3, is a metastasis-related protein tyrosine phosphatase. Its expression levels are significantly correlated with the progression and survival of a wide range of malignant tumors. However, the mechanism by which PRL-3 promotes tumor invasion and metastasis is not clear. In the present study, the functions of PRL-3 were systemically analyzed in the key events of metastasis including, motility and adhesion. A cell wounding assay, cell spread assay and cell-matrix adhesion assay were carried out to analyze the cell movement and cell adhesion ability of colon cancer, immunoprecipitation and immunofluorescence assay was confirmed the interaction of PRL-3 and JAM2...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27328425/ptp4a3-is-a-target-for-inhibition-of-cell-proliferatin-migration-and-invasion-through-akt-mtor-signaling-pathway-in-glioblastoma-under-the-regulation-of-mir-137
#5
Liling Wang, Jianxun Liu, Zhiqiang Zhong, Xuhai Gong, Wei Liu, Lei Shi, Xuesong Li
Glioblastoma multiforme (GBM) is one of the most common primary malignant adult brain tumors. It is characterized by aggressive progression and poor prognosis. There is significant need to understand the mechanism of GBM malignancy and develop improved therapeutic options for GBM patients. We systematically studied the function of PTP4A3 in the malignancy of GBM. We found that PTP4A3 was upregulated in GBM tissues and cells. Knockdown of PTP4A3 expression in GBM cells inhibited cell proliferation, migration, and invasion...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27291491/photooxygenation-of-an-amino-thienopyridone-yields-a-more-potent-ptp4a3-inhibitor
#6
Joseph M Salamoun, Kelley E McQueeney, Kalyani Patil, Steven J Geib, Elizabeth R Sharlow, John S Lazo, Peter Wipf
The phosphatase PTP4A3 is an attractive anticancer target, but knowledge of its exact role in cells remains incomplete. A potent, structurally novel inhibitor of the PTP4A family was obtained by photooxygenation of a less active, electron-rich thienopyridone (1). Iminothienopyridinedione 13 displays increased solution stability and is readily obtained by two new synthetic routes that converge in the preparation of 1. The late-stage photooxygenation of 1 to give 13 in high yield highlights the potential of this reaction to modify the structure and properties of a biological lead compound and generate value for expanding the scope of an SAR investigation...
July 6, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27096756/protein-tyrosine-phosphatase-4a3-ptp4a3-promotes-human-uveal-melanoma-aggressiveness-through-membrane-accumulation-of-matrix-metalloproteinase-14-mmp14
#7
Selma Maacha, Océane Anezo, Malika Foy, Géraldine Liot, Laurence Mery, Cécile Laurent, Xavier Sastre-Garau, Sophie Piperno-Neumann, Nathalie Cassoux, Nathalie Planque, Simon Saule
PURPOSE: To study PTP4A3 phosphatase and MMP14 metalloprotease synergy in uveal melanoma aggressiveness. METHODS: Cell membrane localization of matrix metalloprotease 14 (MMP14) in uveal melanoma cells expressing protein tyrosine phosphatase A3 (PTP4A3) was assessed by flow cytometry or immunohistochemistry. The vesicular trafficking of MMP14 in the presence of PTP4A3 was evaluated in OCM-1 cells expressing either the wild-type or mutated phosphatase. Finally, MMP14 localization at the cell membrane of OCM-1 cells was impaired using RNA interference, and the PTP4A3-related migration in vitro and invasiveness in vivo of the treated cells were evaluated...
April 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26921331/phosphatase-ptp4a3-promotes-triple-negative-breast-cancer-growth-and-predicts-poor-patient-survival
#8
Petra den Hollander, Kathryn Rawls, Anna Tsimelzon, Jonathan Shepherd, Abhijit Mazumdar, Jamal Hill, Suzanne A W Fuqua, Jenny C Chang, C Kent Osborne, Susan G Hilsenbeck, Gordon B Mills, Powel H Brown
Triple-negative breast cancer (TNBC) has the worst prognosis of all breast cancers, and women diagnosed with TNBC currently lack targeted treatment options. To identify novel targets for TNBC, we evaluated phosphatase expression in breast tumors and characterized their contributions to in vitro and in vivo growth of TNBC. Using Affymetrix microarray analysis of 102 breast cancers, we identified 146 phosphatases that were significantly differentially expressed in TNBC compared with estrogen receptor (ER)-positive tumors...
April 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26433386/overexpression-of-ptp4a3-is-associated-with-metastasis-and-unfavorable-prognosis-in-bladder-cancer
#9
Hsin-Chih Yeh, Chun-Nung Huang, Ching-Chia Li, Lin-Li Chang, Hui-Hui Lin, Hung-Lung Ke, A-Mei Huang, Peir-In Liang, Chien-Feng Li, Wen-Jeng Wu
PURPOSE: Bladder cancer (BC) is the most common malignancy in urinary system. The prognosis of metastatic BC is poor, but there remains no reliable marker to early detect metastasis. Dysregulated prenylated protein tyrosine phosphatases (PTPs) are commonly associated with cancer metastasis. From a published BC transcriptome, we identified that PTP IVA3 (PTP4A3) was the most significantly upregulated gene implicated in tumor progression among genes related to prenylated PTPs. We therefore analyzed PTP4A3 expression in our well-characterized cohort of BC...
June 2016: World Journal of Urology
https://www.readbyqxmd.com/read/26203261/the-prognostic-significance-of-protein-tyrosine-phosphatase-4a2-in-breast-cancer
#10
Duanzheng Zhao, Libin Guo, Henrique Neves, Hiu-Fung Yuen, Shu-Dong Zhang, Cian M McCrudden, Qing Wen, Jin Zhang, Qi Zeng, Hang Fai Kwok, Yao Lin
Although PTP4A3 has been shown to be a very important factor in promoting cancer progression, the role of its close family member PTP4A2 is still largely unknown. Recent reports have shown contradicting results on the role of PTP4A2 in breast cancer progression. Considering this, we aimed to investigate the prognostic value of PTP4A2 in five independent breast cancer data sets (minimum 198 patients per cohort, totaling 1,124 patients) in the Gene Expression Omnibus Database. We found that high expression of PTP4A2 was a favorable prognostic marker in all five independent breast cancer data sets, as well as in the combined cohort, with a hazard ratio of 0...
2015: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26070892/ptp4a3-independently-predicts-metastasis-and-survival-in-upper-tract-urothelial-carcinoma-treated-with-radical-nephroureterectomy
#11
Hsin-Chih Yeh, Ching-Chia Li, Chun-Nung Huang, Tzyh-Chyuan Hour, Bi-Wen Yeh, Wei-Ming Li, Peir-In Liang, Lin-Li Chang, Chien-Feng Li, Wen-Jeng Wu
PURPOSE: Increasing evidence has shown that protein tyrosine phosphatases have dominant roles in setting the levels of tyrosine phosphorylation and promoting oncogenic processes. PTP4A3 has been implicated in cancer metastasis but to our knowledge the role of PTP4A3 in upper tract urothelial carcinoma is unknown. The aim of this study was to investigate the association of PTP4A3 with disease characteristics, distant metastasis and prognosis of upper tract urothelial carcinoma. MATERIALS AND METHODS: The importance of PTP4A3 was initially examined in paired normal urothelium, noninvasive upper tract urothelial carcinoma, invasive upper tract urothelial carcinoma and nodal metastatic tissue...
November 2015: Journal of Urology
https://www.readbyqxmd.com/read/25136802/a-role-of-autophagy-in-ptp4a3-driven-cancer-progression
#12
Yu-Han Huang, Abdul Qader O Al-Aidaroos, Hiu-Fung Yuen, Shu-Dong Zhang, Han-Ming Shen, Ewelina Rozycka, Cian M McCrudden, Vinay Tergaonkar, Abhishek Gupta, You Bin Lin, Jean Paul Thiery, James T Murray, Qi Zeng
Autophagy, a "self-eating" cellular process, has dual roles in promoting and suppressing tumor growth, depending on cellular context. PTP4A3/PRL-3, a plasma membrane and endosomal phosphatase, promotes multiple oncogenic processes including cell proliferation, invasion, and cancer metastasis. In this study, we demonstrate that PTP4A3 accumulates in autophagosomes upon inhibition of autophagic degradation. Expression of PTP4A3 enhances PIK3C3-BECN1-dependent autophagosome formation and accelerates LC3-I to LC3-II conversion in an ATG5-dependent manner...
October 1, 2014: Autophagy
https://www.readbyqxmd.com/read/24950307/deletion-of-ptp4a3-reduces-clonogenicity-and-tumor-initiation-ability-of-colitis-associated-cancer-cells-in-mice
#13
Julie M Cramer, Mark W Zimmerman, Tim Thompson, Gregg E Homanics, John S Lazo, Eric Lagasse
The PTP4A3 gene is highly expressed in human colon cancer and often associates with enhanced metastatic potential. Genetic disruption of the mouse Ptp4a3 gene reduces the frequency of colon tumor formation in mice treated in a colitis-associated cancer model. In the current study, we have examined the role of Ptp4a3 in the tumor-initiating cell population of mouse colon tumors using an in vitro culture system. Tumors generated in vivo following AOM/DSS treatment were isolated, dissociated, and expanded on a feeder layer resulting in a CD133(+) cell population, which expressed high levels of Ptp4a3...
July 2014: Stem Cell Research
https://www.readbyqxmd.com/read/24832164/clinicopathologic-comparison-of-plasmablastic-lymphoma-in-hiv-positive-immunocompetent-and-posttransplant-patients-single-center-series-of-25-cases-and-meta-analysis-of-277-reported-cases
#14
Julie Morscio, Daan Dierickx, Jan Nijs, Gregor Verhoef, Emilie Bittoun, Xanne Vanoeteren, Iwona Wlodarska, Xavier Sagaert, Thomas Tousseyn
Plasmablastic lymphoma (PBL) is a rare B-cell non-Hodgkin lymphoma often associated with Epstein-Barr virus (EBV) infection. To gain insight in this aggressive lymphoma subtype, the clinicopathologic characteristics of 25 unpublished single-center PBLs (2 in acquired immunodeficiency syndrome patients, 11 in immunocompetent individuals [IC-PBL], 12 in transplant recipients [PT-PBL]) and of 277 reported PBLs were summarized. In the reported series, PBL patients were predominantly male (77%) with a median age at diagnosis of 46 years (range, 1...
July 2014: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24753135/prl2-ptp4a2-phosphatase-is-important-for-hematopoietic-stem-cell-self-renewal
#15
Michihiro Kobayashi, Yunpeng Bai, Yuanshu Dong, Hao Yu, Sisi Chen, Rui Gao, Lujuan Zhang, Mervin C Yoder, Reuben Kapur, Zhong-Yin Zhang, Yan Liu
Hematopoietic stem cell (HSC) self-renewal is tightly controlled by cytokines and other signals in the microenvironment. While stem cell factor (SCF) is an early acting cytokine that activates the receptor tyrosine kinase KIT and promotes HSC maintenance, how SCF/KIT signaling is regulated in HSCs is poorly understood. The protein tyrosine phosphatase 4A (PTP4A) family (aka PRL [phosphatase of regenerating liver] phosphatases), consisting of PTP4A1/PRL1, PTP4A2/PRL2, and PTP4A3/PRL3, represents an intriguing group of phosphatases implicated in cell proliferation and tumorigenesis...
July 2014: Stem Cells
https://www.readbyqxmd.com/read/24625356/investigational-inhibitors-of-ptp4a3-phosphatase-as-antineoplastic-agents
#16
REVIEW
Elizabeth R Sharlow, Peter Wipf, Kelley E McQueeney, Ahmet Bakan, John S Lazo
INTRODUCTION: Protein tyrosine (Tyr) phosphatases have been implicated in many diseases, most notably in cancer. While there are a significant number of clinically approved inhibitors of protein Tyr kinases, there are no drugs specifically targeting protein Tyr phosphatases in clinical use despite the attractiveness of the molecular target. AREAS COVERED: This review examines the investigational challenges in identifying Tyr phosphatase inhibitors using the oncogenic phosphatase PTP4A3 as a prototype...
May 2014: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/24403062/protein-tyrosine-phosphatase-4a3-ptp4a3-promotes-vascular-endothelial-growth-factor-signaling-and-enables-endothelial-cell-motility
#17
Mark W Zimmerman, Kelley E McQueeney, Jeffrey S Isenberg, Bruce R Pitt, Karla A Wasserloos, Gregg E Homanics, John S Lazo
Protein-tyrosine phosphatase 4A3 (PTP4A3) is highly expressed in multiple human cancers and is hypothesized to have a critical, albeit poorly defined, role in the formation of experimental tumors in mice. PTP4A3 is broadly expressed in many tissues so the cellular basis of its etiological contributions to carcinogenesis may involve both tumor and stromal cells. In particular, PTP4A3 is expressed in the tumor vasculature and has been proposed to be a direct target of vascular endothelial growth factor (VEGF) signaling in endothelial cells...
February 28, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24376839/protein-tyrosine-phosphatase-4a3-ptp4a3-is-required-for-xenopus-laevis-cranial-neural-crest-migration-in-vivo
#18
Selma Maacha, Nathalie Planque, Cécile Laurent, Caterina Pegoraro, Océane Anezo, Frédérique Maczkowiak, Anne H Monsoro-Burq, Simon Saule
Uveal melanoma is the most common intraocular malignancy in adults, representing between about 4% and 5% of all melanomas. High expression levels of Protein Tyrosine Phosphatase 4A3, a dual phosphatase, is highly predictive of metastasis development and PTP4A3 overexpression in uveal melanoma cells increases their in vitro migration and in vivo invasiveness. Melanocytes, including uveal melanocytes, are derived from the neural crest during embryonic development. We therefore suggested that PTP4A3 function in uveal melanoma metastasis may be related to an embryonic role during neural crest cell migration...
2013: PloS One
https://www.readbyqxmd.com/read/24353162/genetic-gains-and-losses-in-oral-squamous-cell-carcinoma-impact-on-clinical-management
#19
Ilda Patrícia Ribeiro, Francisco Marques, Francisco Caramelo, João Pereira, Miguel Patrício, Hugo Prazeres, José Ferrão, Maria José Julião, Miguel Castelo-Branco, Joana Barbosa de Melo, Isabel Poiares Baptista, Isabel Marques Carreira
PURPOSE: The identification of genetic markers associated with oral cancer is considered essential to improve the diagnosis, prognosis, early tumor and relapse detection and, ultimately, to delineate individualized therapeutic approaches. Here, we aimed at identifying such markers. METHODS: Multiplex Ligation-dependent Probe Amplification (MLPA) analyses encompassing 133 cancer-related genes were performed on a panel of primary oral tumor samples and its corresponding resection margins (macroscopically tumor-free tissue) allowing, in both types of tissue, the detection of a wide arrange of copy number imbalances on various human chromosomes...
February 2014: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/24194935/genome-wide-analysis-of-differentially-expressed-genes-and-splicing-isoforms-in-clear-cell-renal-cell-carcinoma
#20
Alessio Valletti, Margherita Gigante, Orazio Palumbo, Massimo Carella, Chiara Divella, Elisabetta Sbisà, Apollonia Tullo, Ernesto Picardi, Anna Maria D'Erchia, Michele Battaglia, Loreto Gesualdo, Graziano Pesole, Elena Ranieri
Clear cell renal cell carcinoma (ccRCC) is the most common malignant renal epithelial tumor and also the most deadly. To identify molecular changes occurring in ccRCC, in the present study we performed a genome wide analysis of its entire complement of mRNAs. Gene and exon-level analyses were carried out by means of the Affymetrix Exon Array platform. To achieve a reliable detection of differentially expressed cassette exons we implemented a novel methodology that considered contiguous combinations of exon triplets and candidate differentially expressed cassette exons were identified when the expression level was significantly different only in the central exon of the triplet...
2013: PloS One
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