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Fatigue and multiple sclerosis

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https://www.readbyqxmd.com/read/28544407/no-relevant-impact-of-ambient-temperature-on-disability-measurements-in-a-large-cohort-of-patients-with-multiple-sclerosis
#1
J-P Stellmann, K L Young, E Vettorazzi, J Pöttgen, C Heesen
BACKGROUND AND PURPOSE: Many patients with multiple sclerosis (MS) report a worsening of symptoms due to high ambient temperatures, but objective data about this association are rare and contradictory. The aim of this study was to investigate the influence of ambient temperature on standard clinical tests. METHODS: We extracted the Symbol Digit Modality Test, Nine Hole Peg Test, Timed 25 Foot Walk (T25FW), Timed Tandem Walk, Expanded Disability Status Scale (EDSS) and quality-of-life items on cognition, fatigue and depression from our clinical database and matched them to historical temperatures...
June 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28539075/fatigue-in-multiple-sclerosis-associations-with-clinical-mri-and-csf-parameters
#2
Viola Biberacher, Paul Schmidt, Rebecca C Selter, Verena Pernpeinter, Markus C Kowarik, Benjamin Knier, Dorothea Buck, Muna-Miriam Hoshi, Thomas Korn, Achim Berthele, Jan S Kirschke, Claus Zimmer, Bernhard Hemmer, Mark Mühlau
BACKGROUND: Damage of different brain structures has been related to fatigue. Alternatively, functional alterations of central nervous system (CNS) cells by the inflammatory milieu within the CNS may be responsible for the development of fatigue. AIM: To investigate the effect of structural brain damage and inflammatory cerebrospinal fluid (CSF) changes on fatigue in multiple sclerosis (MS). METHODS: We determined the association of different clinical, CSF and magnetic resonance imaging (MRI) parameters with prevalence and severity of fatigue, as measured by the Fatigue Scale for Motor and Cognitive Functions in 68 early MS patients (discovery cohort)...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28535557/endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-chronic-fatigue-syndrome-multiple-sclerosis-and-controls-an-observational-study
#3
Simon M Collin, Jo Nijs, Mira Meeus, Andrea Polli, Barbara Willekens, Kelly Ickmans
BACKGROUND: Commonalities in the core symptoms of fatigue and cognitive dysfunction experienced by chronic fatigue syndrome (CFS, also known as ME) and multiple sclerosis (MS) patients have been described. Many CFS and MS patients also experience chronic pain, which has been attributed to central sensitization in both groups of patients. However, the characteristics of pain in CFS and MS patients have not been compared. OBJECTIVES: To compare experimental pain measurements in patients with CFS or MS and healthy controls...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28534643/bicams-in-the-argentine-population-relationship-with-clinical-and-sociodemographic-variables
#4
Sandra Vanotti, A Smerbeck, María B Eizaguirre, Maria L Saladino, Ralph R H Benedict, Fernando J Caceres
The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed to provide valid assessment of cognitive impairment in multiple sclerosis (MS). The relationship between clinical and social variables and cognitive disorders has been extensively studied, but primarily in developed countries with a focus on other cognitive measures or batteries. The objectives of this study were to analyze the relationship between the BICAMS data and key clinical and sociodemographic variables in the Argentine MS population...
May 23, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28532229/fatigue-after-a-first-attack-of-suspected-multiple-sclerosis
#5
Roos M van der Vuurst de Vries, Jan Ja van den Dorpel, Julia Y Mescheriakova, Tessel F Runia, Naghmeh Jafari, Theodora Am Siepman, Dimitris Rizopoulos, Ewout W Steyerberg, Rogier Q Hintzen
BACKGROUND: Fatigue is reported by more than 75% of multiple sclerosis (MS) patients. In an earlier study, we showed that fatigue is not only a common symptom in patients at time of clinically isolated syndrome (CIS; fatigued 46%) but also predicts subsequent diagnosis of clinically definite multiple sclerosis (CDMS). The course of fatigue after CIS is unknown. OBJECTIVE: We aimed to explore the long-term course of fatigue after CIS. METHODS: In this study, 235 CIS patients, aged 18-50 years, were prospectively followed...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28528567/cognitive-behavioral-therapy-positively-affects-fatigue-in-patients-with-multiple-sclerosis-results-of-a-randomized-controlled-trial
#6
Lizanne E van den Akker, Heleen Beckerman, Emma H Collette, Jos Wr Twisk, Gijs Bleijenberg, Joost Dekker, Hans Knoop, Vincent de Groot
BACKGROUND: Fatigue is a common symptom in multiple sclerosis (MS) and often restricts societal participation. Cognitive behavioral therapy (CBT) may alleviate MS-related fatigue, but evidence in literature is inconclusive. OBJECTIVE: To evaluate the effectiveness of CBT to improve MS-related fatigue and participation. METHODS: In a multi-center, assessor-masked, randomized controlled trial, participants with severe MS-related fatigue were assigned to CBT or control treatment...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28528566/does-aerobic-training-alleviate-fatigue-and-improve-societal-participation-in-patients-with-multiple-sclerosis-a-randomized-controlled-trial
#7
Martin Heine, Olaf Verschuren, Erwin Lj Hoogervorst, Erik van Munster, Hub Ga Hacking, Anne Visser-Meily, Jos Wr Twisk, Heleen Beckerman, Vincent de Groot, Gert Kwakkel
BACKGROUND: Evidence supporting the effectiveness of aerobic training, specific for fatigue, in severely fatigued patients with multiple sclerosis (MS) is lacking. OBJECTIVE: To estimate the effectiveness of aerobic training on MS-related fatigue and societal participation in ambulant patients with severe MS-related fatigue. METHODS: Patients ( N = 90) with severe MS-related fatigue were allocated to 16-week aerobic training or control intervention...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28528565/effectiveness-of-energy-conservation-management-on-fatigue-and-participation-in-multiple-sclerosis-a-randomized-controlled-trial
#8
Lyan Jm Blikman, Jetty van Meeteren, Jos Wr Twisk, Fred Aj de Laat, Vincent de Groot, Heleen Beckerman, Henk J Stam, Johannes Bj Bussmann
BACKGROUND: Fatigue is a frequently reported and disabling symptom in multiple sclerosis (MS). OBJECTIVE: To investigate the effectiveness of an individual energy conservation management (ECM) intervention on fatigue and participation in persons with primary MS-related fatigue. METHODS: A total of 86 severely fatigued and ambulatory adults with a definite diagnosis of MS were randomized in a single-blind, two-parallel-arm randomized clinical trial to the ECM group or the information-only control group in outpatient rehabilitation departments...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28516431/a-comparison-of-neuroimaging-abnormalities-in-multiple-sclerosis-major-depression-and-chronic-fatigue-syndrome-myalgic-encephalomyelitis-is-there-a-common-cause
#9
REVIEW
Gerwyn Morris, Michael Berk, Basant K Puri
There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes...
May 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28495217/individuals-with-mild-ms-with-poor-sleep-quality-have-impaired-visuospatial-memory-and-lower-perceived-functional-abilities
#10
Catherine F Siengsukon, Mayis Aldughmi, Melike Kahya, Sharon Lynch, Jared Bruce, Morgan Glusman, Abigail Ness Norouzinia, Sandra Billinger
BACKGROUND: Sleep disturbances are common in individuals with Multiple Sclerosis (MS), but the impact of poor sleep quality on cognitive and physical function in individuals with MS is less clear. OBJECTIVE/HYPOTHESIS: The purpose of this study was to examine the relationship between sleep quality and cognitive and physical function in individuals with mild MS. METHODS: Forty individuals with relapsing-remitting or secondary-progressive MS (50...
April 29, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28490349/cognitive-behavioural-therapy-for-the-management-of-inflammatory-bowel-disease-fatigue-with-a-nested-qualitative-element-study-protocol-for-a-randomised-controlled-trial
#11
Micol Artom, Wladyslawa Czuber-Dochan, Jackie Sturt, Christine Norton
BACKGROUND: Fatigue is one of the most prevalent and burdensome symptoms for patients with inflammatory bowel disease (IBD). Although fatigue increases during periods of inflammation, for some patients it persists when disease is in remission. Compared to other long-term conditions where fatigue has been extensively researched, optimal management of fatigue in patients with IBD is unknown and fatigue has rarely been the primary outcome in intervention studies. To date, interventions for the management of IBD-fatigue are sparse, have short-term effects and have not been implemented within the existing health system...
May 11, 2017: Trials
https://www.readbyqxmd.com/read/28457906/widespread-cortical-demyelination-of-both-hemispheres-can-be-induced-by-injection-of-pro-inflammatory-cytokines-via-an-implanted-catheter-in-the-cortex-of-mog-immunized-rats
#12
Muammer Üçal, Michaela Tanja Haindl, Milena Z Adzemovic, Johannes Strasser, Lisa Theisl, Manuel Zeitelhofer, Klaus Kraitsy, Stefan Ropele, Ute Schäfer, Franz Fazekas, Sonja Hochmeister
Cortical demyelination is a common finding in patients with chronic multiple sclerosis (MS) and contributes to disease progression and overall disability. The exact pathomechanism that leads to cortical lesions is not clear. Research is limited by the fact that standard animal models of multiple sclerosis do not commonly affect the cortex, or if they do in some variants, the cortical demyelination is rather sparse and already remyelinated within a few days. In an attempt to overcome these limitations we implanted a tissue-compatible catheter into the cortex of Dark Agouti rats...
April 27, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28450892/cognition-and-fatigue-in-patients-with-relapsing-multiple-sclerosis-treated-by-subcutaneous-interferon-%C3%AE-1a-an-observational-study-skore
#13
Yvonne Benešová, Aleš Tvaroh
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system, which often causes progressive neurological disability. In addition to motor and sensory dysfunction, cognitive decline and fatigue are frequent manifestations of the disease. Fatigue is probably the most common symptom, with up to 90% of MS individuals reporting fatigue at some point. Cognitive impairment affects about 50% of patients and may be present at all MS stages. The aim of this observational study was to evaluate changes in cognition, fatigue, and disability status in 300 relapsing-remitting MS (RRMS) patients, treated with subcutaneous (sc) interferon (IFN) β-1a over 2 years...
January 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28450891/adrenocorticotropic-hormone-versus-methylprednisolone-added-to-interferon-%C3%AE-in-patients-with-multiple-sclerosis-experiencing-breakthrough-disease-a-randomized-rater-blinded-trial
#14
Regina Berkovich, Rohit Bakshi, Lilyana Amezcua, Robert C Axtell, Steven Y Cen, Shahamat Tauhid, Mohit Neema, Lawrence Steinman
BACKGROUND: The objective of this study was to evaluate monthly intramuscular adrenocorticotropic hormone (ACTH) gel versus intravenous methylprednisolone (IVMP) add-on therapy to interferon β for breakthrough disease in patients with relapsing forms of multiple sclerosis. METHODS: This was a prospective, open-label, examiner-blinded, 15-month pilot study evaluating patients with Expanded Disability Status Scale (EDSS) score 3.0-6.5 and at least one clinical relapse or new T2 or gadolinium-enhanced lesion in the previous year...
January 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28445083/fatigue-and-physical-functioning-in-children-with-multiple-sclerosis-and-acute-disseminated-encephalomyelitis
#15
Leontien Cc Toussaint-Duyster, Yu Yi M Wong, Monique Hm Van der Cammen-van Zijp, Daniëlle Van Pelt-Gravesteijn, Coriene E Catsman-Berrevoets, Rogier Q Hintzen, Rinze F Neuteboom
BACKGROUND AND OBJECTIVE: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL). METHODS: In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4-17 years attending our national pediatric MS center, were studied...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28444253/fear-of-falling-in-people-with-multiple-sclerosis-which-clinical-characteristics-are-important
#16
Hanan Khalil, Alham Al-Shorman, Khalid El-Salem, Nour Abdo, Alia A Alghwiri, Aseel Aburub, Sarah Shalabi, Firas Al-Mustafa
Background.: Fear of falling (FOF) is an important risk indicator for health related outcomes and quality of life in patients with multiple sclerosis (MS). However, factors associated with FOF in MS are not well investigated. Objectives.: This study was done to explore predictors of FOF in this population. Methods.: Seventy relapsing remitting patients with MS were evaluated. FOF was assessed using Fall Efficacy Scale-International (FES-I)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28442320/people-with-multiple-sclerosis-report-significantly-worse-symptoms-and-health-related-quality-of-life-than-the-us-general-population-as-measured-by-promis-and-neuroqol-outcome-measures
#17
Dagmar Amtmann, Alyssa M Bamer, Jiseon Kim, Hyewon Chung, Rana Salem
BACKGROUND: Individuals with multiple sclerosis (MS) report fatigue, pain, depression, cognitive difficulties, and other symptoms. It is often difficult to compare symptoms across studies and populations because scales used to measure individual symptoms or quality of life indicators (QOLI) use different metrics and often do not provide norms. PROMIS and Neuro-QOL measures, developed with modern psychometric methods, use a common metric and provide population norms. OBJECTIVE: To create symptom profiles and compare symptoms and QOLIs of people living with MS to a US general population sample...
April 21, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28438714/the-effect-of-morphological-and-microstructural-integrity-of-the-corpus-callosum-on-cognition-fatigue-and-depression-in-mildly-disabled-ms-patients
#18
Jeroen Van Schependom, Jeroen Gielen, Jorne Laton, Georgios Sotiropoulos, Anne-Marie Vanbinst, Johan De Mey, Dirk Smeets, Guy Nagels
AIM: To assess the value of callosal morphological and microstructural integrity in assessing different cognitive domains, fatigue and depression in mildly disabled multiple sclerosis (MS) patients. MATERIALS AND METHODS: We assessed 29 mildly disabled MS patients and 15 healthy controls using 3T magnetic resonance images (T1-weighted, FLAIR and DTI) and neuropsychological tests assessing different cognitive functions, depression and fatigue. We compared the added value of morphological measures (corpus callosum area corrected for total intracranial volume, index, circularity and the more detailed thickness profile) and diffusion features (fractional anisotropy and mean diffusivity) in multilinear models including standard clinical and whole-brain parameters in assessing neuropsychological scores...
April 24, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28434551/neuromuscular-fatigue-during-exercise-methodological-considerations-etiology-and-potential-role-in-chronic-fatigue
#19
REVIEW
Rosie Twomey, Saied Jalal Aboodarda, Renata Kruger, Susan Nicole Culos-Reed, John Temesi, Guillaume Y Millet
The term fatigue is used to describe a distressing and persistent symptom of physical and/or mental tiredness in certain clinical populations, with distinct but ultimately complex, multifactorial and heterogenous pathophysiology. Chronic fatigue impacts on quality of life, reduces the capacity to perform activities of daily living, and is typically measured using subjective self-report tools. Fatigue also refers to an acute reduction in the ability to produce maximal force or power due to exercise. The classical measurement of exercise-induced fatigue involves neuromuscular assessments before and after a fatiguing task...
April 20, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28434462/the-effects-of-tai-chi-on-physical-and-psychosocial-function-among-persons-with-multiple-sclerosis-a-systematic-review
#20
REVIEW
Emily Taylor, Ruth E Taylor-Piliae
OBJECTIVES: Conduct a systematic review to evaluate the effects of Tai Chi on physical and psychosocial function among individuals with Multiple Sclerosis. METHODS: An electronic literature search of 12 databases using controlled vocabulary function and keywords from inception through August 2016. All Tai Chi intervention studies assessing physical and psychosocial function among persons with Multiple Sclerosis were included. Study quality was scored using an established tool examining 16 study elements (range=0-32)...
April 2017: Complementary Therapies in Medicine
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