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Fatigue and multiple sclerosis

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https://www.readbyqxmd.com/read/29332021/the-effects-of-reflexology-on-fatigue-and-anxiety-in-patients-with-multiple-sclerosis
#1
Afitap Ozdelikara, Seval Agcadiken Alkan
Context • Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. In addition to the progressive nature of the disease, devastating symptoms adversely affect the patient's daily life and future expectations. This situation leads patients to seek complementary and alternative treatments. Objectives • This study was conducted to determine the effects of reflexology on fatigue severity and anxiety in patients with MS. Design • The research was a quasi-experimental, pretest-posttest design...
January 15, 2018: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29329698/effect-of-combined-exercise-training-on-serum-brain-derived-neurotrophic-factor-suppressors-of-cytokine-signaling-1-and-3-in-patients-with-multiple-sclerosis
#2
C Ozkul, A Guclu-Gunduz, C Irkec, I Fidan, Y Aydin, T Ozkan, G Yazici
BACKGROUND: Suppressors of cytokine signaling (SOCS) and brain-derived neurotrophic factor (BDNF) are important immunologic, and neurotrophic factors for MS pathogenesis. The impact of exercise on these factors is yet to be fully elucidated in patients with MS. OBJECTIVE: The primary aim of this study is to investigate the effect of 8-week combined exercise training on serum concentrations of SOCS1, SOCS3, and BDNF. The secondary aim is to determine the effects of combined exercise training on balance, functional exercise capacity, and fatigue in patients with MS...
January 3, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29324506/a-pilot-mixed-methods-evaluation-of-ms-inform-a-self-directed-fatigue-management-resource-for-individuals-with-multiple-sclerosis
#3
Nadine Akbar, Karen Turpin, Julie Petrin, Penny Smyth, Marcia Finlayson
Fatigue management interventions for individuals with multiple sclerosis (MS) often feature structured programmes requiring repeated, in-person attendance that is not possible for all individuals. We sought to determine whether MS INFoRm, a self-directed fatigue management resource for individuals with MS, was worth further, more rigorous evaluation. Our indicators of worthiness were actual use of the resource by participants over 3 months, reductions in fatigue impact and increases in self-efficacy, and participant reports of changes in fatigue management knowledge and behaviours...
January 10, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29324301/depression-and-fatigue-in-multiple-sclerosis-relation-to-exposure-to-violence-and-cerebrospinal-fluid-immunomarkers
#4
Philip Brenner, Mathias Granqvist, Johan Königsson, Faiez Al Nimer, Fredrik Piehl, Jussi Jokinen
Multiple sclerosis (MS) is a neuroinflammatory condition characterized by chronic dysregulation of immune responses leading to repeated episodes of inflammation in the central nervous system. Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events. IL-6 and IL-8 have been associated with depression and stressful life events in non-MS patients. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the cerebrospinal fluid (CSF) of MS patients...
January 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29318030/environmental-temperature-and-exercise-modality-independently-impact-central-and-muscle-fatigue-among-people-with-multiple-sclerosis
#5
Geetika Grover, Michelle Ploughman, Devin T Philpott, Liam P Kelly, Augustine J Devasahayam, Katie Wadden, Kevin E Power, Duane C Button
Background: Heat sensitivity and fatigue limit the ability of multiple sclerosis patients to participate in exercise. Objective: The purpose of this study was to determine the optimal aerobic exercise parameters (environmental temperature and exercise modality) to limit exercise-induced central and muscle fatigue among people with multiple sclerosis. Methods: Fourteen people with multiple sclerosis with varying levels of disability completed four randomized exercise sessions at 65% of the maximal volume of oxygen: body-weight supported treadmill cool (16°C), body-weight supported treadmill room (21°C), total-body recumbent stepper cool and total-body recumbent stepper room...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29318028/interferon-beta-1b-in-treatment-na%C3%A3-ve-paediatric-patients-with-relapsing-remitting-multiple-sclerosis-two-year-results-from-the-betapaedic-study
#6
Jutta Gärtner, Wolfgang Brück, Almuth Weddige, Hannah Hummel, Christiane Norenberg, Jörg-Peter Bugge
Background and objective: Study evaluating Betaferon(R)'s safety and tolerability in paediatric patients with multiple sclerosis (BETAPAEDIC) is a prospective, open-label observational multicentre study to assess the safety and effectiveness of interferon beta-1b in paediatric patients with relapsing-remitting multiple sclerosis. Methods: Treatment-naïve patients (12-16 years) scheduled to start interferon beta-1b were enrolled with follow-up visits every six months for two years...
October 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/29313870/aerobic-capacity-explains-physical-functioning-and-participation-in-patients-with-multiple-sclerosis-related-fatigue
#7
Emma Rosalie Driehuis, Lizanne Eva van den Akker, Vincent de Groot, Heleen Beckerman
OBJECTIVE: To investigate whether aerobic capacity explains the level of self-reported physical activity, physical functioning, and participation and autonomy in daily living in persons with multiple sclerosis-related fatigue. DESIGN: A cross-sectional study. PATIENTS: Sixty-two participants with multiple sclerosis-related fatigue. METHODS: Aerobic capacity was measured with a leg ergometer and was expressed as maximal oxygen uptake (VO2max, in ml/kg/min)...
January 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29306741/on-the-role-of-the-amygdala-for-experiencing-fatigue-in-patients-with-multiple-sclerosis
#8
Katrin Hanken, Yoselin Francis, Andreas Kastrup, Paul Eling, Jan Klein, Helmut Hildebrandt
BACKGROUND: Recently, we proposed a model explaining the origin of fatigue in multiple sclerosis (MS) patients. This model assumes that the feeling of fatigue results from inflammation-induced information processing within interoceptive brain areas. OBJECTIVES: To investigate the association between self-reported cognitive fatigue and structural integrity of interoceptive brain areas in MS patients. METHODS: 95 MS patients and 28 healthy controls participated in this study...
December 21, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29306594/vertebrobasilar-artery-stroke-as-the-heralding-sign-of-systemic-lupus-erythematosus
#9
Reza Mohammadian, Ali Tarighatnia, Mehran Naghibi, Evin Koleini, Nader D Nader
Cerebral ischemia because of vertebrobasilar insufficiency (VBI) rarely presents as an initial sign within the systemic lupus erythematosus (SLE) population, and there are very few case reports supporting this manifestation. This report details 3 different patients with SLE who experienced VBI as an initial manifestation. Patient 1 was a 24-year-old female who developed a bilateral pontine lesion as a consequence of basilar artery stenosis. Patient 2 was a 34-year-old male with an acute ischemic lesion on the right side of his cerebellum and pons because of significant stenosis in the distal segment of the right vertebral artery...
January 3, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29301779/what-have-we-learned-from-mr-imaging-in-multiple-sclerosis
#10
REVIEW
E Lapointe, D K B Li, A L Traboulsee, A Rauscher
Using MR imaging, perfusion can be assessed either by dynamic susceptibility contrast MR imaging or arterial spin-labeling. Alterations of cerebral perfusion have repeatedly been described in multiple sclerosis compared with healthy controls. Acute lesions exhibit relative hyperperfusion in comparison with normal-appearing white matter, a finding mostly attributed to inflammation in this stage of lesion development. In contrast, normal-appearing white and gray matter of patients with MS has been mostly found to be hypoperfused compared with controls, and correlations with cognitive impairment as well as fatigue in multiple sclerosis have been described...
January 4, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29300700/understanding-the-physiological-significance-of-four-inertial-gait-features-in-multiple-sclerosis
#11
Sriram Raju Dandu, Matthew M Engelhard, Asma Qureshi, Jiaqi Gong, John C Lach, Maite Brandt-Pearce, Myla D Goldman
Gait impairment in multiple sclerosis (MS) can result from muscle weakness, physical fatigue, lack of coordination, and other symptoms. Walking speed, as measured by a number of clinician-administered walking tests, is the primary measure of gait impairment used by clinical researchers, but inertial gait features from body-worn sensors have been proven to add clinical value. This paper seeks to understand and differentiate the physiological significance of four such features with proven value in MS to facilitate adoption by clinical researchers and incorporation in gait monitoring and analysis systems...
January 2018: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/29300228/loneliness-in-multiple-sclerosis-possible-antecedents-and-correlates
#12
Julia M Balto, Lara A Pilutti, Robert W Motl
PURPOSE: The prevalence and possible antecedents and correlates of loneliness in multiple sclerosis (MS) was examined. DESIGN: Cross-sectional, comparative study of MS (n = 63) and healthy adults (n = 21). METHODS: Data were collected using self-reports of loneliness and antecedents and correlates and analyzed using inferential statistics. FINDINGS: Those with MS had significantly higher loneliness scores than healthy adults (p < ...
January 3, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29275790/the-clinical-utility-of-metacognitive-beliefs-and-processes-in-emotional-distress-in-people-with-multiple-sclerosis
#13
Philip Heffer-Rahn, Peter L Fisher
AIM: Multiple sclerosis (MS) is a chronic demyelinating disease that poses significant life challenges. Depression and anxiety often occur in people with MS (PwMS). An information processing model of psychopathology, the Self-Regulatory Executive Function (S-REF) model specifies that maladaptive metacognitive beliefs play a fundamental role in the development and maintenance of distress. The model also asserts that a style of thinking known as the cognitive attentional syndrome (CAS), which consists of worry and rumination, focusing on sources of threat, and unhelpful coping responses, is common across all psychological conditions...
January 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29275058/determining-reliable-change-on-the-modified-fatigue-impact-scale-5-item-version
#14
Julia Smith, Amanda S Bruce, Morgan Glusman, Joanie Thelen, Sharon Lynch, Jared M Bruce
BACKGROUND: Fatigue is prevalent in Multiple Sclerosis (MS), but little research indicates how to best quantify changes in fatigue over time. OBJECTIVE: Evaluate reliable change on the abbreviated Modified Fatigue Impact Scale (MFIS-5) in MS patients. METHODS: One-hundred sixty eight MS patients completed the MFIS-5 at baseline and follow-up as part of two larger studies. Test-retest reliability scores and reliable change indices were calculated...
December 14, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29250012/the-effectiveness-of-a-body-affective-mindfulness-intervention-for-multiple-sclerosis-patients-with-depressive-symptoms-a-randomized-controlled-clinical-trial
#15
Sara Carletto, Valentina Tesio, Martina Borghi, Diana Francone, Francesco Scavelli, Gabriella Bertino, Simona Malucchi, Antonio Bertolotto, Francesco Oliva, Riccardo Torta, Luca Ostacoli
Purpose: Mindfulness interventions have been shown to treat depressive symptoms and improve quality of life in patients with several chronic diseases, including multiple sclerosis, but to date most evaluation of the effectiveness of mindfulness interventions in multiple sclerosis have used patients receiving standard care as the control group. Hence we decided to evaluate the effectiveness of a group-based body-affective mindfulness intervention by comparing it with a psycho-educational intervention, by means of a randomized controlled clinical trial...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29246607/smart-watch-smarter-edss-improving-disability-assessment-in-multiple-sclerosis-clinical-practice
#16
Gloria Dalla-Costa, Marta Radaelli, Simona Maida, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Giancarlo Comi, Vittorio Martinelli
BACKGROUND: Patients' walking ability is critical for assessing the EDSS, the disability scale commonly used in MS clinical practice. Such assessment is usually based on patients' estimates or on the measures the neurologists observe during periodic visits. OBJECTIVES AND METHODS: We evaluated the agreement between patients' and neurologists' estimates of maximum walking ability and patients' mean maximum walking ability measured in their daily life through a GPS smartwatch, and assessed limitations of the current methods...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29234305/functional-components-of-cognitive-impairment-in-multiple-sclerosis-a-cross-sectional-investigation
#17
Jordi A Matias-Guiu, Ana Cortés-Martínez, María Valles-Salgado, Celia Oreja-Guevara, Vanesa Pytel, Paloma Montero, Teresa Moreno-Ramos, Jorge Matias-Guiu
Background: Cognitive impairment is frequent and disabling in multiple sclerosis (MS). Changes in information processing speed constitute the most important cognitive deficit in MS. However, given the clinical and topographical variability of the disease, cognitive impairment may vary greatly and appear in other forms in addition to slower information processing speed. Our aim was to determine the frequency of cognitive impairment, the principal cognitive domains, and components involved in MS and to identify factors associated with presence of cognitive impairment in these patients in a large series of patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29226778/a-multicenter-randomized-controlled-trial-of-two-group-education-programs-for-fatigue-in-multiple-sclerosis-short-and-medium-term-benefits
#18
Cinda L Hugos, Zunqiu Chen, Yiyi Chen, Aaron P Turner, Jodie Haselkorn, Toni Chiara, Sean McCoy, Christopher T Bever, Michelle H Cameron, Dennis Bourdette
Background Fatigue occurs in 75%-95% of people with multiple sclerosis (MS) and is frequently reported as the most disabling symptom. A multicomponent group program of six weekly 2-hour sessions, Fatigue: Take Control (FTC), was developed from an international MS fatigue management guideline. Objective To determine whether FTC is associated with greater improvements in fatigue than MS: Take Control (MSTC), a similarly structured general MS education program. Methods This four-site, parallel, single-blind, randomized controlled trial compared FTC and MSTC in 204 ambulatory participants with MS...
December 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29220866/neural-correlates-of-fatigue-in-multiple-sclerosis-a-combined-neurophysiological-and-neuroimaging-approach-r1
#19
M Russo, A Calamuneri, A Cacciola, L Bonanno, A Naro, V Dattola, E Sessa, M Buccafusca, D Milardi, P Bramanti, R S Calabrò, A Quartarone
The present study is aimed at further exploring structural and functional correlates of fatigue in Relapsing- Remitting Multiple Sclerosis (RRMS) patients by using a combined approach by means of transcranial magnetic stimulation (TMS) and a Diffusion Tensor Imaging (DTI). The physiopathology of fatigue in MS is still poorly understood, although a variety of pathogenic mechanisms has been proposed. Our working hypothesis is that diffuse microstructural white matter damage may subtend the cortico-subcortical functional disconnection described in patients with MS and fatigue...
September 30, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29212827/diet-quality-is-associated-with-disability-and-symptom-severity-in-multiple-sclerosis
#20
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert Fox, Ruth Ann Marrie
OBJECTIVE: To assess the association between diet quality and intake of specific foods with disability and symptom severity in people with multiple sclerosis (MS). METHODS: In 2015, participants in the North American Research Committee on MS (NARCOMS) Registry completed a dietary screener questionnaire that estimates intake of fruits, vegetables and legumes, whole grains, added sugars, and red/processed meats. We constructed an overall diet quality score for each individual based on these food groups; higher scores denoted a healthier diet...
January 2, 2018: Neurology
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