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Fatigue and multiple sclerosis

Chiara Concetta Incerti, Ornella Argento, Giuseppe Magistrale, Elisabetta Ferraro, Carlo Caltagirone, Valerio Pisani, Ugo Nocentini
Multiple sclerosis (MS) and working status have recently arisen great interest. Fatigue, physical disability, cognition, and psychological disturbances have been linked to unemployment, as well to accidents during daily activities. The aim of our study was to determine frequency of different types of accidents at workplace (AWE) and possible clinical differences among employed (MSe) and unemployed (MSu) MS patients. Sixty MS patients (31 employed, 29 unemployed) and twenty healthy control subjects were recruited...
October 19, 2016: Neurological Sciences
E Sebastião, E A Hubbard, R E Klaren, L A Pilutti, R W Motl
This study compared physical fitness components between fatigued and non-fatigued persons with MS and examined those components as correlates of fatigue. Sixty-two ambulatory persons with MS completed the Modified Fatigue Impact Scale (MFIS) and underwent assessments of cardiorespiratory capacity, lower extremity muscle strength (i.e., peak torque and asymmetry), body composition, and static balance over two different sessions 7 days apart. Participants were allocated into fatigue groups based on MFIS scores (non-fatigued group (i...
October 17, 2016: Scandinavian Journal of Medicine & Science in Sports
Annie C Bowles, Amy L Strong, Rachel M Wise, Robert C Thomas, Brittany Y Gerstein, Maria F Dutreil, Ryan S Hunter, Jeffrey M Gimble, Bruce A Bunnell
Multiple sclerosis (MS) is a common neurodegenerative disease and remains an unmet clinical challenge. In MS, an autoimmune response leads to immune cell infiltration, inflammation, demyelination, and lesions in central nervous system (CNS) tissues resulting in tremors, fatigue, and progressive loss of motor function. These pathologic hallmarks are effectively reproduced in the murine experimental autoimmune encephalomyelitis (EAE) model. The stromal vascular fraction (SVF) of adipose tissue is composed of adipose-derived stromal/stem cells (ASC), adipocytes, and various leukocytes...
October 12, 2016: Stem Cells
Patrick Vermersch, Maria Trojano
BACKGROUND: Tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray (Sativex®) is an add-on therapy for moderate-to-severe multiple sclerosis (MS)-related drug-resistant spasticity (MSS). AIM: The MOVE-2 EU study collected data from everyday clinical practice concerning the effectiveness and tolerability of THC:CBD. METHODS: This was an observational, prospective, multicentre, non-interventional study. Patients with resistant MSS prescribed add-on THC:CBD oromucosal spray according to approved labelling, were followed for 3 months...
October 13, 2016: European Neurology
Shengli Ma, Xue Rui, Peiyi Qi, Gangqiong Liu, Jing Yang
BACKGROUND: Poor sleep is common in patients with multiple sclerosis (MS). This study assessed the prevalence of poor sleep and investigated the potential impact factors that influence sleep quality of patients with MS. METHODS: A cross-sectional self-report survey of 231 patients with MS and 265 sex- and age-matched controls was conducted. Good sleepers and poor sleepers were separated by their global score on the Pittsburgh Sleep Quality Index (PSQI). Sociodemographic parameters, such as age, gender, and marital status, and clinical-demographic parameters, such as excessive daytime sleepiness (measured by the Epworth Sleepiness Scale), snoring, insomnia, obstructive sleep apnea, drugs, pain, depression, fatigue, and quality of life, were registered...
October 11, 2016: Sleep & Breathing, Schlaf & Atmung
Mariarosa Rottoli, Sara La Gioia, Barbara Frigeni, Valeria Barcella
Fatigue is one of the most common symptoms associated with multiple sclerosis, affecting almost 80% of patients with 55% of them reporting it as one of the worst symptoms experienced, often independently of the level of disability. Areas covered: We review the main pathophysiological hypothesis, fatigue assessment scales, and its management. Expert commentary: Fatigue pathophysiology is complex and is often influenced by other secondary but relevant factors (e.g. psychological disturbances, musculoskeletal problems, sleep disorders and medication side effects) which may vary over time...
October 11, 2016: Expert Review of Neurotherapeutics
Stephanie A Grover, Carolyn P Sawicki, Dominique Kinnett-Hopkins, Marcia Finlayson, Jane E Schneiderman, Brenda Banwell, Christine Till, Robert W Motl, E Ann Yeh
OBJECTIVES: To investigate physical activity levels in youth with multiple sclerosis and monophasic acquired demyelinating syndromes ([mono-ADS], ie, children without relapsing disease) compared with healthy controls and to determine factors that contribute to engagement in physical activity. We hypothesized that greater physical activity goal setting and physical activity self-efficacy would be associated with greater levels of vigorous physical activity in youth with multiple sclerosis...
October 4, 2016: Journal of Pediatrics
Carina Sander, Paul Eling, Katrin Hanken, Jan Klein, Andreas Kastrup, Helmut Hildebrandt
BACKGROUND: Fatigue is a disabling syndrome in multiple sclerosis (MS), which may be associated with inflammation and faster disease progression. OBJECTIVE: To analyze the significance of cognitive fatigue for subsequent disease progression. METHOD: We followed 46 MS patients and 14 healthy controls in a study over 17 months. At the beginning (t1) and at the end (t2) of the study participants scored their fatigue, performed the Multiple Sclerosis Functional Composite and received MRI scanning, encompassing MPR T1, FLAIR, and DTI sequences...
2016: Frontiers in Neurology
Katrin Hanken, Mona Bosse, Kim Möhrke, Paul Eling, Andreas Kastrup, Andrea Antal, Helmut Hildebrandt
BACKGROUND: Fatigue in multiple sclerosis (MS) patients appears to correlate with vigilance decrement as reflected in an increase in reaction time (RT) and errors with prolonged time-on-task. OBJECTIVES: The aim of this study was to investigate whether anodal transcranial direct current stimulation (tDCS) over the right parietal or frontal cortex counteracts fatigue-associated vigilance decrement and subjective fatigue. METHODS: In study I, a randomized double-blind placebo-controlled study, anodal tDCS (1...
2016: Frontiers in Neurology
Alexander Tallner, René Streber, Christian Hentschke, Marc Morgott, Wolfgang Geidl, Mathias Mäurer, Klaus Pfeifer
Physical exercise is effective in improving functional outcomes in persons with multiple sclerosis (pwMS). We evaluated the feasibility and effectiveness of internet-based exercise training (e-training) for pwMS on health-related quality of life (HrQoL). Secondary outcomes were muscle strength, aerobic capacity, lung function, physical activity, and fatigue. This is a randomised, controlled trial with a wait-list control group. Data were collected at baseline, after three and six months, and analysed using a hybrid linear model...
September 30, 2016: International Journal of Molecular Sciences
Jeff Boissoneault, Janelle Letzen, Song Lai, Michael E Robinson, Roland Staud
Studies using arterial spin labelling (ASL) have shown that individuals with chronic fatigue syndrome (CFS) have decreased regional cerebral blood flow, which may be associated with changes in functional neural networks. Indeed, recent studies indicate disruptions in functional connectivity (FC) at rest in chronically fatigued patients including perturbations in static FC (sFC), that is average FC at rest between several brain regions subserving neurocognitive, motor and affect-related networks. Whereas sFC often provides information of functional network reorganization in chronic illnesses, investigations of temporal changes in functional connectivity between multiple brain areas may shed light on the dynamic characteristics of brain network activation associated with such maladies...
September 28, 2016: Clinical Physiology and Functional Imaging
Béatrice Médée, Jean-Baptiste Bouée, Olivier Remy-Neris
OBJECTIVE: Maintaining physical activity for patient with neurological disorders is recommended for patient with multiple sclerosis (MS). The main objective was to assess physical activity and rehabilitation programs in patients with multiple sclerosis and compared it to recently published recommendations. The secondary objective was to evaluate the patient self-perception of these interventions on pain, fatigue, strength and global satisfaction. MATERIALS/PATIENTS AND METHODS: A prospective multicenter study conducted in the four counties of Brittany for patients with MS attending a consultation with a neurologist in the MS network "NeuroSEP Bretagne"...
September 2016: Annals of Physical and Rehabilitation Medicine
François Kopciuch
OBJECTIVE: Walking disorders are common in patients with multiple sclerosis (MS). Among these, walking fatigability is a common complaint of patients, but it needs to be better characterized. This work aims to compare the fatigability induced by a 2, and a 6- minute walk test (2MWT; 6MWT) and to investigate the factors associated with it. MATERIALS/PATIENTS AND METHODS: Twenty-seven MS patients (divided into subgroups according to disease severity [EDSS 3-4 and 4...
September 2016: Annals of Physical and Rehabilitation Medicine
Eva De Pin, Yoshimasa Sagawa, Thierry Moulin, Pierre Decavel
OBJECTIVE: Fatigue and gait impairment are two of the most common and disabling symptoms in patients with multiple sclerosis (PwMS). If on one side, the gait evaluation of PwMS is well established, on the other side, there is no consensus about which instrument is the most pertinent and reproducible to evaluate fatigue in PwMS [1]. The objectives of this study were: - to determine which fatigue scales is the most reproducible and; - to establish the associations between fatigue scales and the gait of PwMS...
September 2016: Annals of Physical and Rehabilitation Medicine
Maxime Valet, Gaëtan Stoquart, Yumiko Glibert, Jean-Claude Hakizimana, Thierry Lejeune
OBJECTIVE: Fatigue is the most common and disabling symptom among patients suffering from multiple sclerosis (MS). From the initial stages of the disease, a physical deconditioning is also observed among these patients. The aim of this study is to assess the cardiorespiratory endurance (i.e. exercise tolerance functions) and self-reported fatigue, as well as their associations, among patients suffering from MS with mild disability (expanded disability status scale≤4). MATERIALS/PATIENTS AND METHODS: 21 patients with MS (15 women; age: 26-64 years, median 46 years; duration of disease: 0...
September 2016: Annals of Physical and Rehabilitation Medicine
Yoshimasa Sagawa, Eric Watelain, Thierry Moulin, Pierre Decavel
OBJECTIVE: Functional performance reflects what an individual does in his/her daily life, providing a crucial dimension of the environmental role on his/her function. The assessment of the functional performance status of persons with multiple sclerosis (PwMS) is a useful tool to optimize healthcare. This concept does not seem to be extensively explored in this population [1,2]. This study aimed to determine the level of activity of PwMS during weekdays and weekends, and to establish associations between clinical and functional parameters and this level of physical activity...
September 2016: Annals of Physical and Rehabilitation Medicine
Mehri Christopher, Yoshimasa Sagawa, Céline Bernard, Thierry Moulin, Eloi Magnin, Pierre Decavel
OBJECTIVE: Fampridine is used as a symptomatic treatment in patients with multiple sclerosis (PwMS) gait disorders. Some clinical trials reported a positive effect on cognitive function especially on information-processing speed (IPS) or on fatigue. The aim of our clinical trial was to evaluate the effect of fampridine on IPS. MATERIAL/PATIENTS AND METHODS: 60 PwMS with an EDSS score between 4 and 7 were included in a prospective monocentric open label trial. Two identical measures were conducted a week apart before initiating treatment in order to take into account the test-retest effect...
September 2016: Annals of Physical and Rehabilitation Medicine
Kevin G Burfeind, Vijayshree Yadav, Daniel L Marks
Signs and symptoms of multiple sclerosis are usually attributed to demyelinating lesions in the spinal cord or cerebral cortex. The hypothalamus is a region that is often overlooked yet controls many important homeostatic functions, including those that are perturbed in multiple sclerosis. In this review we discuss how hypothalamic dysfunction may contribute to signs and symptoms in people with multiple sclerosis. While dysfunction of the hypothalamic-pituitary-adrenal axis is common in multiple sclerosis, the effects and mechanisms of this dysfunction are not well understood...
November 2016: Current Neurology and Neuroscience Reports
Bahram Sangelaji, Mohammadreza Kordi, Farzaneh Banihashemi, Seyed Massood Nabavi, Sara Khodadadeh, Maryam Dastoorpoor
BACKGROUND: Multiple sclerosis (MS) is a neurological disease with a variety of signs and symptoms. Exercise therapy has been shown to improve physical functions in MS. However, questions about an optimal exercise therapy remain. In this regard, we suggest a combined exercise therapy including aerobic and resistance exercises for MS patients. The study is designed to observe, test and compare the effects of proposed combined exercises on strength, balance, agility, fatigue, speed, and walking distance in people with mild to moderate MS [0 < expanded disability status scale (EDSS) < 5]...
July 6, 2016: Iranian Journal of Neurology
Vijayshree Yadav, Gail Marracci, Edward Kim, Rebecca Spain, Michelle Cameron, Shannon Overs, Andrew Riddehough, David K B Li, John McDougall, Jesus Lovera, Charles Murchison, Dennis Bourdette
BACKGROUND: The role that dietary interventions can play in multiple sclerosis (MS) management is of huge interest amongst patients and researchers but data evaluating this is limited. Possible effects of a very-low-fat, plant-based dietary intervention on MS related progression and disease activity as measured by brain imaging and MS related symptoms have not been evaluated in a randomized-controlled trial. Despite use of disease modifying therapies (DMT), poor quality of life (QOL) in MS patients can be a significant problem with fatigue being one of the common disabling symptoms...
September 2016: Multiple Sclerosis and related Disorders
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