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Fatigue and MS

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https://www.readbyqxmd.com/read/28445083/fatigue-and-physical-functioning-in-children-with-multiple-sclerosis-and-acute-disseminated-encephalomyelitis
#1
Leontien Cc Toussaint-Duyster, Yu Yi M Wong, Monique Hm Van der Cammen-van Zijp, Daniëlle Van Pelt-Gravesteijn, Coriene E Catsman-Berrevoets, Rogier Q Hintzen, Rinze F Neuteboom
BACKGROUND AND OBJECTIVE: Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL). METHODS: In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4-17 years attending our national pediatric MS center, were studied...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28444253/fear-of-falling-in-people-with-multiple-sclerosis-which-clinical-characteristics-are-important
#2
Hanan Khalil, Alham Al-Shorman, Khalid El-Salem, Nour Abdo, Alia A Alghwiri, Aseel Aburub, Sarah Shalabi, Firas Al-Mustafa
Background.: Fear of falling (FOF) is an important risk indicator for health related outcomes and quality of life in patients with multiple sclerosis (MS). However, factors associated with FOF in MS are not well investigated. Objectives.: This study was done to explore predictors of FOF in this population. Methods.: Seventy relapsing remitting patients with MS were evaluated. FOF was assessed using Fall Efficacy Scale-International (FES-I)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28442320/people-with-multiple-sclerosis-report-significantly-worse-symptoms-and-health-related-quality-of-life-than-the-us-general-population-as-measured-by-promis-and-neuroqol-outcome-measures
#3
Dagmar Amtmann, Alyssa M Bamer, Jiseon Kim, Hyewon Chung, Rana Salem
BACKGROUND: Individuals with multiple sclerosis (MS) report fatigue, pain, depression, cognitive difficulties, and other symptoms. It is often difficult to compare symptoms across studies and populations because scales used to measure individual symptoms or quality of life indicators (QOLI) use different metrics and often do not provide norms. PROMIS and Neuro-QOL measures, developed with modern psychometric methods, use a common metric and provide population norms. OBJECTIVE: To create symptom profiles and compare symptoms and QOLIs of people living with MS to a US general population sample...
April 21, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28438714/the-effect-of-morphological-and-microstructural-integrity-of-the-corpus-callosum-on-cognition-fatigue-and-depression-in-mildly-disabled-ms-patients
#4
Jeroen Van Schependom, Jeroen Gielen, Jorne Laton, Georgios Sotiropoulos, Anne-Marie Vanbinst, Johan De Mey, Dirk Smeets, Guy Nagels
Aim To assess the value of callosal morphological and microstructural integrity in assessing different cognitive domains, fatigue and depression in mildly disabled multiple sclerosis (MS) patients. MATERIALS AND METHODS: We assessed 29 mildly disabled MS patients and 15 healthy controls using 3T magnetic resonance images (T1-weighted, FLAIR and DTI) and neuropsychological tests assessing different cognitive functions, depression and fatigue. We compared the added value of morphological measures (corpus callosum area corrected for total intracranial volume, index, circularity and the more detailed thickness profile) and diffusion features (fractional anisotropy and mean diffusivity) in multilinear models including standard clinical and whole-brain parameters in assessing neuropsychological scores...
April 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28427709/upper-limb-impairment-is-associated-with-use-of-assistive-devices-and-unemployment-in-multiple-sclerosis
#5
Ruth Ann Marrie, Gary R Cutter, Tuula Tyry, Stacey S Cofield, Robert Fox, Amber Salter
BACKGROUND: Individuals with multiple sclerosis (MS) frequently suffer from impaired sensory function, reduced strength and tremor in the upper limbs, which may interfere with upper limb function. However, upper limb impairment in MS is under-recognized and understudied. We aimed to evaluate the prevalence of upper limb impairment in a large sample of persons with MS; the association between upper limb function and employment status in MS; and the frequency of use of assistive devices aimed at addressing upper limb impairments...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28421200/detection-of-urine-metabolites-in-a-rat-model-of-chronic-fatigue-syndrome-before-and-after-exercise
#6
Changzhuan Shao, Yiming Ren, Zinan Wang, Chenzhe Kang, Hongke Jiang, Aiping Chi
Purpose. The aim of the present study was to elucidate the metabolic mechanisms associated with chronic fatigue syndrome (CFS) via an analysis of urine metabolites prior to and following exercise in a rat model. Methods. A rat model of CFS was established using restraint-stress, forced exercise, and crowded and noisy environments over a period of 4 weeks. Behavioral experiments were conducted in order to evaluate the model. Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS) in combination with multivariate statistical analysis before and after exercise...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28419819/path-to-illness-intrusiveness-what-symptoms-impact-the-life-of-people-living-with-multiple-sclerosis
#7
Vanessa Bouchard, Pierre Duquette, Nancy E Mayo
OBJECTIVE: To determine the direct and indirect effects of physical, emotional, and cognitive impairments on illness intrusiveness in people with MS. DESIGN: Secondary analysis of a cross sectional data set collected in 2008 to identify gender differences in people living with MS. SETTING: Three MS clinics in the Greater Montréal region, Canada. PARTICIPANTS: A random sample of 135 women and 48 men diagnosed with Multiple Sclerosis after 1995 recruited and evaluated in 2008...
April 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28417835/objective-vs-subjective-evaluation-of-cognitive-performance-during-0-4-mpa-dives-breathing-air-or-nitrox
#8
Peter Germonpré, Costantino Balestra, Walter Hemelryck, Peter Buzzacott, Pierre Lafère
BACKGROUND: Divers try to limit risks associated with their sport, for instance by breathing enriched air nitrox (EANx) instead of air. This double blinded, randomized trial was designed to see if the use of EANx could effectively improve cognitive performance while diving. METHODS: Eight volunteers performed two no-decompression dry dives breathing air or EANx for 20 min at 0.4 MPa. Cognitive functions were assessed with a computerized test battery, including MathProc and Ptrail...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28416274/fatigue-in-multiple-sclerosis-insights-into-evaluation-and-management
#9
REVIEW
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system, characterized by the accumulation of numerous neurological symptoms and signs throughout its course. Fatigue is one of the most distressing complaints that MS patients may experience over their lifetime. In spite of its high prevalence, the pathophysiology of MS fatigue is far from being fully elucidated and a constellation of mechanisms seems implicated in this setting. Several factors could contribute to its development and/or exacerbation, and this requires a careful workup in order to search for all possible underlying causes, such as sleep disturbances, endocrine dysfunction and mood disorders, to cite a few...
April 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28413944/the-assessment-of-motor-fatigability-in-persons-with-multiple-sclerosis-a-systematic-review
#10
Deborah Severijns, Inge Zijdewind, Ulrik Dalgas, Ilse Lamers, Caroline Lismont, Peter Feys
BACKGROUND: Persons with multiple sclerosis (PwMS) are often characterized by increased motor fatigability, which is a performance change on an objectively measured criterion after any type of voluntary muscle contractions. This review summarizes the existing literature to determine which protocols and outcome measures are best to detect or study motor fatigability and the underlying mechanisms in MS. METHODS: Two electronic databases, PubMed and Web of Science, were searched for relevant articles published until August 2016 with a combination of multiple sclerosis, fatigability, muscle fatigue, and motor fatigue...
May 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28394724/a-multimodal-nonpharmacologic-intervention-improves-mood-and-cognitive-function-in-people-with-multiple-sclerosis
#11
Jennifer E Lee, Babita Bisht, Michael J Hall, Linda M Rubenstein, Rebecca Louison, Danielle T Klein, Terry L Wahls
OBJECTIVE: The objective of this study was to examine whether participation in a 12-month multimodal intervention would improve mood and cognitive function in adults with progressive multiple sclerosis (MS). METHODS: In this one-arm, open-label feasibility trial, participants were prescribed a home-based multimodal intervention, including (1) a modified Paleolithic diet; (2) an exercise program (stretching and strengthening of the trunk and lower limb muscles); (3) neuromuscular electrical stimulation (EStim) of trunk and lower limb muscles; and (4) stress management (meditation and self-massage)...
March 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28387447/withdrawn-interventions-for-fatigue-and-weight-loss-in-adults-with-advanced-progressive-illness
#12
REVIEW
Cathy Payne, Philip J Wiffen, Suzanne Martin
BACKGROUND: Fatigue and unintentional weight loss are two of the commonest symptoms experienced by people with advanced progressive illness. Appropriate interventions may bring considerable improvements in function and quality of life to seriously ill people and their families, reducing physical, psychological and spiritual distress. OBJECTIVES: To conduct an overview of the evidence available on the efficacy of interventions used in the management of fatigue and/or unintentional weight loss in adults with advanced progressive illness by reviewing the evidence contained within Cochrane reviews...
April 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28368955/combined-carbohydrate-and-protein-ingestion-during-australian-rules-football-matches-and-training-sessions-does-not-reduce-fatigue-or-accelerate-recovery-throughout-a-week-long-junior-tournament
#13
Nathan A Lee, James W Fell, Nathan W Pitchford, Andrew H Hall, Michael D Leveritt, Cecilia M Kitic
Australian Rules football (ARF) is a physically demanding sport that can induce high levels of fatigue. Fatigue may be intensified during periods where multiple matches are played with limited recovery time. Combined carbohydrate and protein (CHO+PRO) intake during physical activity may provide performance and recovery benefits. The aim of this study was to investigate whether CHO+PRO ingestion during ARF matches and training sessions throughout a tournament would enhance performance or recovery in comparison to CHO-only ingestion...
March 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28359851/characterization-of-a-protein-bound-polysaccharide-from-herba-epimedii-and-its-metabolic-mechanism-in-chronic-fatigue-syndrome
#14
Aiping Chi, Zhimei Shen, Wenfei Zhu, Yuliang Sun, Yijiang Kang, Fei Guo
OBJECTIVES: Herba Epimedii is one of the famous Traditional Chinese Medicines used to treat the chronic fatigue syndrome (CFS). The polysaccharides are the main active components in H. epimedii. The aim of this study is to discover the therapeutic effect and metabolic mechanism of H. epimedii polysaccharides against CFS. METHODS: The polysaccharide conjugates named HEP2-a were isolated from the leaves of H. epimedii using a water extraction method, and the general physicochemical properties of HEP2-a were analysed...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28347292/protocol-for-a-randomized-double-blind-placebo-controlled-crossover-trial-of-melatonin-for-treatment-of-nocturia-in-adults-with-multiple-sclerosis-menims
#15
D Delgado, L Canham, N Cotterill, D Cottrell, M J Drake, K Inglis, D Owen, P White
BACKGROUND: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacity to carry out daily activities. Melatonin is a natural hormone regulating circadian cycles, released by the pineal gland at night-time, and secretion is impaired in MS. Melatonin levels can be supplemented by administration in tablet form at bedtime. The aim of this study is to evaluate the effect of melatonin on mean number of nocturia episodes per night in MS patients...
March 27, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28342828/-resistance-training-for-muscle-weakness-in-multiple-sclerosis-direct-versus-contralateral-approach-in-individuals-with-ankle-dorsiflexors-disparity-in-strength
#16
Andrea Manca, Maria Paola Cabboi, Daniele Dragone, Francesca Ginatempo, Enzo Ortu, Edoardo Rosario De Natale, Beniamina Mercante, Giovanni Mureddu, Guido Bua, Franca Deriu
OBJECTIVE: To compare effects of contralateral strength training (CST) versus direct strength training (DST) of the more-affected ankle dorsiflexors on muscle performance and clinical-functional outcomes in people with multiple sclerosis (MS) exhibiting inter-limb strength asymmetry. DESIGN: Randomized controlled trial PARTICIPANTS: Individuals with relapsing-remitting MS and mild-to-moderate disability (EDSS≤6) presenting with ankle dorsiflexors' strength disparity...
March 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28340429/simple-index-of-functional-connectivity-at-rest-in-multiple-sclerosis-fatigue
#17
Korhan Buyukturkoglu, Camillo Porcaro, Carlo Cottone, Andrea Cancelli, Matilde Inglese, Franca Tecchio
OBJECTIVE: To investigate the EEG-derived functional connectivity at rest (FCR) patterns of fatigued Multiple Sclerosis (MS) patients in order to find good parameters for a future EEG-Neurofeedback intervention to reduce their fatigue symptoms. METHODS: We evaluated FCR between hemispheric homologous areas, via spectral coherence between pairs of corresponding left and right bipolar derivations, in the Theta, Alpha and Beta bands. We estimated FCR in 18MS patients with different levels of fatigue and minimal clinical severity and in 11 age and gender matched healthy controls...
May 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28315666/feasibility-and-safety-of-a-powered-exoskeleton-for-assisted-walking-for-persons-with-multiple-sclerosis-a-single-group-preliminary-study
#18
Allan J Kozlowski, Michelle Fabian, Dipan Lad, Andrew Delgado
OBJECTIVE: To examine the feasibility, safety, and secondary benefit potential of exoskeleton-assisted walking with one device for persons with multiple sclerosis (MS) DESIGN: Single-group longitudinal preliminary study with 8-week baseline, 8-week intervention, and 4-week follow-up. SETTING: Outpatient MS clinic at tertiary care hospital. PARTICIPANTS: The 13 participants were mostly female who ranged in age from 38-62 years and on Expanded Disability Status Scale scores from 5...
March 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28291023/central-contribution-to-electrically-induced-fatigue-depends-on-stimulation-frequency
#19
Sidney Grosprêtre, Nicolas Gueugneau, Alain Martin, Romuald Lepers
PURPOSE: This study analyzed the impact of several protocols of neuromuscular electrical stimulation (NMES), matched with a similar total torque-time integral, on muscle activation pathways and neuromuscular fatigue. METHODS: Ten young healthy participants (age: 24.6 ± 4.2) performed 3 randomized NMES sessions on the triceps surae muscles with 20 Hz, 60 Hz or 100 Hz stimulation frequencies (pulse duration: 1 ms), with pulse amplitude (IES) set at 20 % of isometric maximal voluntary contraction (MVC)...
March 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28290192/further-construct-validity-of-the-timed-up-and-go-test-as-a-measure-of-ambulation-in-persons-with-multiple-sclerosis
#20
Alon Kalron, Mark Dolev, Uri Givon
BACKGROUND: The importance of mobility impairments in people with multiple sclerosis (PwMS) denotes a need for valid, reliable, sensitive and feasible clinical measuring tools. The Timed Up and Go (TUG) test is a unique mobility measure as it captures other functions apart from walking, ie, rising out of a chair or turning around an object. AIM: To expand the construct validity of the TUG test in PwMS and determine the ability of the TUG score to discriminate between four levels of disability between fallers, recurrent fallers and non-fallers...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
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