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Fatigue and MS

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https://www.readbyqxmd.com/read/28227624/relationship-between-gait-variables-and-domains-of-neurologic-dysfunction-in-multiple-sclerosis-using-six-minute-walk-test
#1
Asma Qureshi, Maite Brandt-Pearce, Myla D Goldman, Asma Qureshi, Maite Brandt-Pearce, Myla D Goldman, Asma Qureshi, Myla D Goldman, Maite Brandt-Pearce
Most multiple sclerosis (MS) patients eventually suffer from mobility impairment, and thus it is critical that walking disability in MS be accurately assessed. The six-minute walk test (6MWT), a reliable MS measure, is traditionally used to determine the distance covered in six minutes using a standard protocol. With the availability of body sensor networks (BSNs), researchers are interested in leveraging BSN data for finding new gait assessment anchors for improved separability performance. Further, current methods for gait assessments are insufficient since assessments are absolute, performed by comparing outcomes to the statistical norms established from diverse patient data despite natural inter-patient variability...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223806/efficacy-of-a-short-cognitive-training-program-in-patients-with-multiple-sclerosis
#2
María Yaiza Pérez-Martín, Montserrat González-Platas, Pablo Eguía-Del Río, Cristina Croissier-Elías, Alejandro Jiménez Sosa
BACKGROUND: Cognitive impairment is a common feature in multiple sclerosis (MS) and may have a substantial impact on quality of life. Evidence about the effectiveness of neuropsychological rehabilitation is still limited, but current data suggest that computer-assisted cognitive training improves cognitive performance. OBJECTIVE: The objective of this study was to evaluate the efficacy of combined computer-assisted training supported by home-based neuropsychological training to improve attention, processing speed, memory and executive functions during 3 consecutive months...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28219104/captopril-does-not-potentiate-post-exercise-hypotension-a-randomized-crossover-study
#3
Andréia Cristiane Carrenho Queiroz, Julio Cesar Silva Sousa, Natan Daniel Silva, Eleonora Tobaldini, Katia Coelho Ortega, Edilamar Menezes de Oliveira, Patricia Chakur Brum, Nicola Montano, Decio Mion, Taís Tinucci, Claudia Lucia de Moraes Forjaz
To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C - rest) and Resistance Exercise (RE - 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM -repetition maximum). Measurements were taken before and after 30-60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h...
February 20, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191860/hypothalamic-damage-in-multiple-sclerosis-correlates-with-disease-activity-disability-depression-and-fatigue
#4
E Kantorová, H Poláček, M Bittšanský, E Baranovičová, P Hnilicová, D Čierny, Š Sivák, V Nosáľ, K Zeleňák, E Kurča
OBJECTIVES: Disturbances in the hypothalamo-pituitary axis are supposed to modulate activity of multiple sclerosis (MS). We hypothesised that the extent of HYP damage may determine severity of MS and may be associated with the disease evolution. We suggested fatigue and depression may depend on the degree of damage of the area. METHOD: 33 MS patients with relapsing-remitting and secondary progressive disease, and 24 age and sex-related healthy individuals (CON) underwent 1H-MR spectroscopy (1H-MRS) of the hypothalamus...
February 13, 2017: Neurological Research
https://www.readbyqxmd.com/read/28188814/how-people-with-multiple-sclerosis-cope-with-a-sustained-finger-motor-task-a-behavioural-and-fmri-study
#5
Laura Bonzano, Matteo Pardini, Luca Roccatagliata, Giovanni L Mancardi, Marco Bove
Motor and non-motor basal ganglia (BG) circuits can help healthy subjects cope with task-induced central fatigue and re-establish motor performance after deterioration. This work aimed to assess whether patients with multiple sclerosis (MS) were able to recover motor performance after deterioration due to a demanding task and whether BG activity played a role in performance recovery in this population. Fourteen patients with MS performed a finger-tapping sequence with their right hand during three fMRI sessions: at baseline, after a demanding finger motor task (5-min sequence repetition) and after a short rest period...
February 7, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28182629/tai-chi-for-health-benefits-in-patients-with-multiple-sclerosis-a-systematic-review
#6
Liye Zou, Huiru Wang, ZhongJun Xiao, Qun Fang, Mark Zhang, Ting Li, Geng Du, Yang Liu
The aim of this systematic review was to evaluate the existing evidence on the effectiveness and safety of Tai chi, which is critical to provide guidelines for clinicians to improve symptomatic management in patients with multiple sclerosis (MS). After performing electronic and manual searches of many sources, ten relevant peer-reviewed studies that met the inclusion criteria were retrieved. The existing evidence supports the effectiveness of Tai chi on improving quality of life (QOL) and functional balance in MS patients...
2017: PloS One
https://www.readbyqxmd.com/read/28174454/effect-of-short-term-fatigue-induced-by-high-intensity-exercise-on-the-profile-of-the-ground-reaction-force-during-single-leg-anterior-drop-jumps
#7
Saya Watanabe, Junya Aizawa, Manabu Shimoda, Mitsuhiro Enomoto, Tomomasa Nakamura, Atushi Okawa, Kazuyoshi Yagishita
[Purpose] Fatigue may be an important contributing factor to non-contact anterior cruciate ligament injuries in sports. The purpose of this study was to evaluate the effects of controlled lower limb fatigue, induced by a short-term, high-intensity exercise protocol, on the profile of the ground reaction force during landings from single-leg anterior drop-jumps. [Subjects and Methods] Twelve healthy males, 18 to 24 years old, performed single-leg anterior drop-jumps, from a 20 cm height, under two conditions, 'fatigue' and 'non-fatigue'...
December 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28166186/between-session-reliability-of-isometric-mid-thigh-pull-kinetics-and-maximal-power-clean-performance-in-male-youth-soccer-players
#8
Thomas Dos'Santos, Christopher Thomas, Paul Comfort, John J McMahon, Paul A Jones, Nick P Oakley, Ashley L Young
The aim of the study was to determine the between-session reliability of isometric mid-thigh pull (IMTP) kinetics and maximal weight lifted during the power clean (PC) in male youth soccer players, and to identify the smallest detectable differences between sessions. Thirteen male youth soccer players (age: 16.7 ± 0.5 years, height: 1.80 ± 0.08 m, mass: 70.5 ± 9.4 kg) performed three IMTP trials, while only ten soccer players performed maximal power cleans. These were performed twice, separated by 48 hours to examine the between-session reliability...
February 1, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28165424/changbai-mountain-ginseng-panax-ginseng-c-a-mey-extract-supplementation-improves-exercise-performance-and-energy-utilization-and-decreases-fatigue-associated-parameters-in-mice
#9
Guo-Dong Ma, Chun-Hui Chiu, Yi-Ju Hsu, Chien-Wen Hou, Yi-Ming Chen, Chi-Chang Huang
Changbai Mountain Ginseng (CMG, Panax ginseng C.A. Mey) is a traditional medicine commonly found in Northeast China and grows at elevations of 2000 m or higher in the Changbai Mountain Range. CMG, considered to be a "buried treasure medicine", is priced higher than other types of ginseng. However, few studies have demonstrated the effects of CMG supplementation on exercise performance, physical fatigue, and the biochemical profile. The major compound of CMG extract was characterized by electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS)...
February 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28165143/potentially-modifiable-factors-associated-with-physical-activity-in-individuals-with-multiple-sclerosis
#10
Nadia Reider, Amber R Salter, Gary R Cutter, Tuula Tyry, Ruth Ann Marrie
Physical activity levels among persons with multiple sclerosis (MS) are worryingly low. We aimed to identify the factors associated with physical activity for people with MS, with an emphasis on factors that have not been studied previously (bladder and hand dysfunction) and are potentially modifiable. This study was a secondary analysis of data collected in the spring of 2012 during the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. NARCOMS participants were surveyed regarding smoking using questions from the Behavioral Risk Factor Surveillance Survey; disability using the Patient Determined Disease Steps; fatigue, cognition, spasticity, sensory, bladder, vision and hand function using self-reported Performance Scales; health literacy using the Medical Term Recognition Test; and physical activity using questions from the Health Information National Trends Survey...
February 6, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28161821/cortical-activity-predicts-good-variation-in-human-motor-output
#11
Sarine Babikian, Eva Kanso, Jason J Kutch
Human movement patterns have been shown to be particularly variable if many combinations of activity in different muscles all achieve the same task goal (i.e., are goal-equivalent). The nervous system appears to automatically vary its output among goal-equivalent combinations of muscle activity to minimize muscle fatigue or distribute tissue loading, but the neural mechanism of this "good" variation is unknown. Here we use a bimanual finger task, electroencephalography (EEG), and machine learning to determine if cortical signals can predict goal-equivalent variation in finger force output...
February 4, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28131211/potential-pathophysiological-pathways-that-can-explain-the-positive-effects-of-exercise-on-fatigue-in-multiple-sclerosis-a-scoping-review
#12
REVIEW
Martin Langeskov-Christensen, Etienne J Bisson, Marcia L Finlayson, Ulrik Dalgas
BACKGROUND: Fatigue is one of the most common and most disabling symptoms of multiple sclerosis (MS). It is a multidimensional and complex symptom with multifaceted origins, involving both central and peripheral fatigue mechanisms. Exercise has proven to be safe for people with MS, with cumulating evidence supporting significant reductions in fatigue. However, the potential pathophysiological pathways that can explain the positive effects of exercise on fatigue in MS remain elusive. OBJECTIVES: The objectives were, in PwMS (1) to update the knowledge on the pathophysiology underlying primary and secondary fatigue, and (2) to discuss potential pathophysiological pathways that can explain the positive effects of exercise on MS fatigue...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130080/fatigability-in-patients-with-multiple-sclerosis-during-maximal-concentric-contractions
#13
Sophie Hameau, Djamel Bensmail, Nicolas Roche, Raphael Zory
OBJECTIVE: To compare quadriceps fatigability during maximal concentric contractions in persons with MS and healthy subjects (HS). DESIGN: Observational study. SETTING: Hospital rehabilitation department PARTICIPANTS: Thirty eight persons with MS and fourteen HS were included. Torque of the knee flexor and extensor muscles and fatigability of the knee extensor muscles were evaluated using an isokinetic device. Surface electromyographic activity of rectus femoris, vastus lateralis, biceps femoris, and semi tendinosus was recorded...
January 24, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28127507/dalfampridine-effects-on-cognition-fatigue-and-dexterity
#14
Melanie Korsen, Rhina Kunz, Ulf Schminke, Uwe Runge, Thomas Kohlmann, Alexander Dressel
OBJECTIVES: Dalfampridine exerts beneficial effects on walking ability in a subgroup of patients with multiple sclerosis (MS). These patients are termed "responders". Here, we investigated whether the responder status with respect to mobility measures would determine whether dalfampridine treatment exerts a beneficial effect on other MS symptoms. We therefore assessed walking ability, upper limb function, cognition, fatigue, visual evoked potentials (VEPs), depression, and quality of life in patients before and after dalfampridine treatment...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28125300/the-impact-of-robot-mediated-adaptive-i-travle-training-on-impaired-upper-limb-function-in-chronic-stroke-and-multiple-sclerosis
#15
Anneleen Maris, Karin Coninx, Henk Seelen, Veronik Truyens, Tom De Weyer, Richard Geers, Mieke Lemmens, Jolijn Coolen, Sandra Stupar, Ilse Lamers, Peter Feys
PURPOSE: The current study aimed to investigate proof-of-concept efficacy of an individualized, robot-mediated training regime for people with MS (pwMS) and stroke patients. METHOD: Thirteen pwMS and 14 chronic stroke patients performed 36 (stroke) or 40 (pwMS) training sessions with the I-TRAVLE system. Evaluation of upper limb function was performed at baseline, after training and at 3 months follow-up. Clinical outcome measures consisted of active range of motion (ROM), Motricity Index, Jamar handgrip strength, perceived fatigue and strength, Wolf Motor Function Test (WFMT) and ABILHAND...
January 26, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28113140/simultaneous-determination-of-multiple-bioactive-components-of-bu-zhong-yi-qi-tang-in-rat-tissues-by-lc-ms-ms-application-to-a-tissue-distribution-study
#16
Min He, Wenwen Chen, Mengmeng Wang, Yu Wu, Jin Zeng, Zhirong Zhang, Shujiao Shen, Jian Jiang
A liquid chromatography coupled with electrospray ionization mass spectrometry method was developed and validated for simultaneous determination of seven bioactive constituents including astragaloside IV, calycosin, glycyrrhizic acid, enoxolone, saikosaponin D, ferulic acid and hesperiden in rats' various tissues using diclofenac as the internal standard (IS). Biological samples were pretreated by protein precipitation with acetonitrile. The chromatographic separation was carried out on a C18 column with a gradient mobile phase consisting of acetonitrile and water (containing 0...
January 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28104254/processing-speed-and-distractibility-in-multiple-sclerosis-the-role-of-sleep
#17
Viral P Patel, Lisa A S Walker, Anthony Feinstein
BACKGROUND: The effects of sleep disturbances on cognitive performance under distraction in multiple sclerosis (MS) are not known. The objective of the present study was to explore the association between an index of sleep (i.e. daytime somnolence), distractibility and the hallmark cognitive deficit in people with MS (i.e. processing speed). METHODS: MS participants (n=102) were recruited from outpatient neurology clinics. All participants completed the traditional Symbol Digit Modalities Test (SDMT)...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104253/the-effect-of-fampridine-sr-on-cognitive-fatigue-in-a-randomized-double-blind-crossover-trial-in-patients-with-ms
#18
Sarah A Morrow, Heather Rosehart, Andrew M Johnson
BACKGROUND: Cognitive fatigue (CF) is a common complaint in persons with MS (PwMS). Fampridine-SR improves ambulation, fatigue and endurance, due to enhancing action potential formation by blocking potassium channels in demyelinated axons. Thus, through this same mechanism, it is hypothesized that Fampridine-SR could improve CF. OBJECTIVE: To determine if Fampridine-SR objectively improves CF in PwMS. METHODS: Sixty PwMS of any type with CF, defined as 3 or less correct responses when comparing the last third to the first third on the Paced Auditory Serial Addition Test (PASAT), were recruited from a tertiary care MS clinic in London (ON) Canada...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28096022/the-interaction-of-fatigue-physical-activity-and-health-related-quality-of-life-in-adults-with-multiple-sclerosis-ms-and-cardiovascular-disease-cvd
#19
Pamela K Newland, Valerie Lunsford, Alicia Flach
In addition to the underlying health problems and disability associated with multiple sclerosis (MS) and cardiovascular disease (CVD), adults with each of these chronic illnesses are independently known to experience fatigue. While fatigue's influence on physical activity and health related quality of life (HRQOL) with each of these illnesses has been discussed, what is lacking is information on how fatigue impacts physical activity and health related quality of life, and ultimately self-management for adults with these conditions...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28093823/sleep-and-its-associations-with-perceived-and-objective-cognitive-impairment-in-individuals-with-multiple-sclerosis
#20
Abbey J Hughes, Brett A Parmenter, Jodie K Haselkorn, Jesus F Lovera, Dennis Bourdette, Eilis Boudreau, Michelle H Cameron, Aaron P Turner
Problems with sleep and cognitive impairment are common among people with multiple sclerosis (MS). The present study examined the relationship between self-reported sleep and both objective and perceived cognitive impairment in MS. Data were obtained from the baseline assessment of a multi-centre intervention trial (NCT00841321). Participants were 121 individuals with MS. Nearly half (49%) of participants met the criteria for objective cognitive impairment; however, cognitively impaired and unimpaired participants did not differ on any self-reported sleep measures...
January 17, 2017: Journal of Sleep Research
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