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Fatigue and MS

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https://www.readbyqxmd.com/read/28096022/the-interaction-of-fatigue-physical-activity-and-health-related-quality-of-life-in-adults-with-multiple-sclerosis-ms-and-cardiovascular-disease-cvd
#1
Pamela K Newland, Valerie Lunsford, Alicia Flach
In addition to the underlying health problems and disability associated with multiple sclerosis (MS) and cardiovascular disease (CVD), adults with each of these chronic illnesses are independently known to experience fatigue. While fatigue's influence on physical activity and health related quality of life (HRQOL) with each of these illnesses has been discussed, what is lacking is information on how fatigue impacts physical activity and health related quality of life, and ultimately self-management for adults with these conditions...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28093823/sleep-and-its-associations-with-perceived-and-objective-cognitive-impairment-in-individuals-with-multiple-sclerosis
#2
Abbey J Hughes, Brett A Parmenter, Jodie K Haselkorn, Jesus F Lovera, Dennis Bourdette, Eilis Boudreau, Michelle H Cameron, Aaron P Turner
Problems with sleep and cognitive impairment are common among people with multiple sclerosis (MS). The present study examined the relationship between self-reported sleep and both objective and perceived cognitive impairment in MS. Data were obtained from the baseline assessment of a multi-centre intervention trial (NCT00841321). Participants were 121 individuals with MS. Nearly half (49%) of participants met the criteria for objective cognitive impairment; however, cognitively impaired and unimpaired participants did not differ on any self-reported sleep measures...
January 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28092018/bladder-dysfunction-in-multiple-sclerosis-a-6-year-follow-up-study
#3
Darija Kisic Tepavcevic, Tatjana Pekmezovic, Irena Dujmovic Basuroski, Sarlota Mesaros, Jelena Drulovic
Bladder dysfunction (BD) is the most common autonomic disturbance in multiple sclerosis, but often overlooked and undertreated. The purpose of this longitudinal study was to explore the changes in the frequency of BD symptoms in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the correlations between the presence of BD symptoms and both clinical characteristics and the health-related quality of life (HRQoL) at each subsequent point of estimation. The study population comprises a cohort of 93 patients with MS (McDonald's criteria, 2001)...
January 13, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28078569/the-computer-based-symbol-digit-modalities-test-establishing-age-expected-performance-in-healthy-controls-and-evaluation-of-pediatric-ms-patients
#4
Sandra Bigi, R A Marrie, C Till, E A Yeh, N Akbar, A Feinstein, B L Banwell
Decreased information processing speed (IPS) is frequently reported in pediatric multiple sclerosis (MS) patients. The computerized version of the Symbol Digit Modalities Test (c-SDMT) measures IPS over eight consecutive trials per session and additionally captures changes in performance within the session. Here, we establish normative c-SDMT performance and test-retest reliability in healthy children (HC) and explore differences in the overall c-SDMT-performance between HC and MS patients. This cross-sectional study included 478 HC (237 female, 49...
January 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28065580/fatigue-favors-in-vitro-th1-and-th17-like-cell-expansion-and-reduces-corticoid-sensitivity-in-ms-patients
#5
Hélcio Alvarenga-Filho, Marisa Salles, Joana Hygino, Thais B Ferreira, Priscila M Sacramento, Clarice Monteiro, Claudia Cristina F Vasconcelos, Regina Maria Papais Alvarenga, Cleonice A M Bento
Fatigue is a common "ghost" symptom in patients with multiple sclerosis (MS), an autoimmune disease mediated by T cells that target myelin antigens of the central nervous system. As fatigue has been associated with inflammatory states, its occurrence may negatively impact MS progression. The aim of this study was to evaluate the impact of fatigue on the cytokine profile of patients with relapsing-remitting (RR) MS. For our study, blood were collected from MS patients in clinical remission phase with (n=15) and without (n=15) fatigue...
December 30, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28048139/su-f-j-227-accuracy-of-passive-magnetic-ultrasound-needle-guidance-in-high-fidelity-conventional-and-novel-simulated-block-approach-phantoms
#6
A Johnson
PURPOSE: The objective of this research was to demonstrate accuracy of a real-time passive ultrasound magnetic needle guidance technology (NGT) and target localization algorithm using conventional anechogenic contact phantoms and a novel fluid-filled hyperechogenic phantom simulating nerve block technique. METHODS: Accuracy (mm to phantom target) was assessed by observing 35 medical practitioners (16 anesthesiologists and 19 residents) performing 560 needle procedures in high-fidelity ex vivo porcine tissue phantoms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045796/physiological-load-and-psychological-stress-during-a-24-hour-work-shift-among-finnish-firefighters
#7
Piia Kaikkonen, Harri Lindholm, Sirpa Lusa
OBJECTIVE: The aim of this study was to describe physiological load and psychological stress of Finnish firefighters during a 24-hour work shift. METHODS: R-R intervals were recorded during 24-hour work shifts. Short-time Fourier transform was used to analyze heart rate variability during shifts. RESULTS: HRmean, HRpeak, and square root of the mean of the sum of the squares of the differences between adjacent R-to-R peak intervals of the 24-hour shift was 73 ± 7 bpm (38 ± 4% of HRmax), 156 ± 16 bpm (82 ± 8% of HRmax), and 42 ± 14 ms...
January 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28035846/employment-and-absenteeism-in-working-age-persons-with-multiple-sclerosis
#8
Amber Salter, Nina Thomas, Tuula Tyry, Gary Cutter, Ruth Ann Marrie
AIMS: To better understand the impact of the clinical course of multiple sclerosis (MS) and disability on employment, absenteeism, and related factors. MATERIALS AND METHODS: We included respondents to the North American Research Committee on Multiple Sclerosis Registry spring 2015 update survey who were United States or Canadian residents, aged 18-65 years and reported having relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), or primary progressive MS (PPMS)...
December 30, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/28032503/correction-to-application-of-lc-ms-based-global-metabolomic-profiling-methods-to-human-mental-fatigue
#9
Zhenling Chen, Xianfa Xu, Jianping Zhang, Yongsuo Liu, Xianggang Xu, Lili Li, Wei Wang, Haishan Xu, Wei Jiang, Yan Wang
No abstract text is available yet for this article.
December 23, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28032077/the-effect-of-group-mindfulness-based-stress-reduction-and-consciousness-yoga-program-on-quality-of-life-and-fatigue-severity-in-patients-with-ms
#10
Somayeh Nejati, Sepideh Rajezi Esfahani, Soheila Rahmani, Gita Afrookhteh, Shahrzad Hoveida
Introduction: The chronic nature of Multiple Sclerosis (MS), have can leave devastating effects on quality of life and fatigue. The present research aimed to study the effect of group Mindfulness-based Stress Reduction (MBSR) and conscious yoga program on the quality of life and fatigue severity among patients with MS. Methods: This study was quasi-experimental with intervention and control groups. The statistical population included all members to MS Society of Tehran Province, 24 of whom diagnosed with MS were selected as the sample based on the inclusion criteria...
December 2016: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28026020/low-pho-boosts-burst-firing-and-catecholamine-release-by-blocking-task-1-and-bk-channels-while-preserving-cav1-channels-in-mouse-chromaffin-cells
#11
Laura Guarina, David H F Vandael, Valentina Carabelli, Emilio Carbone
Mouse chromaffin cells (MCCs) generate action potential (AP) firing that regulates the Ca(2+) -dependent release of catecholamines (CAs). Recent findings indicate that MCCs possess a variety of spontaneous firing modes that span from the common "tonic-irregular" to the less frequent "burst" firing. This latter is evident in a small fraction of MCCs but occurs regularly when Nav1.3/1.7 channels are made less available or when the Slo1β2-subunit responsible for BK channel inactivation is deleted. Burst firing causes massive increases of Ca(2+) -entry and potentiates CA release ∼3...
December 27, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/28017199/effects-of-left-dlpfc-versus-right-ppc-tdcs-on-multiple-sclerosis-fatigue
#12
Moussa A Chalah, Naji Riachi, Rechdi Ahdab, Alaa Mhalla, Mohamed Abdellaoui, Alain Créange, Jean-Pascal Lefaucheur, Samar S Ayache
BACKGROUND AND OBJECTIVE: Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, on such a challenging symptom. Our secondary outcomes included the assessment of tDCS impact on mood and attentional performance. METHODS: Ten fatigued MS patients were enrolled in a double-blind, sham-controlled, and cross-over study...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28009903/creep-and-fatigue-resistant-rapid-piezoresistive-responses-of-elastomeric-graphene-coated-carbon-nanotube-aerogels-over-a-wide-pressure-range
#13
Michelle N Tsui, Mohammad F Islam
Lightweight, flexible piezoresistive materials with wide operational pressure ranges are in demand for applications such as human physical activity and health monitoring, robotics, and for functional interfacing between living systems and wearable electronics. Piezoresistivity of many elastomeric foams of polymers and carbon allotropes satisfies much of the required characteristics for these applications except creep and fatigue resistance due to their viscoelasticity, critically limiting the reliability and lifetime of integrated devices...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28005172/postural-control-is-associated-with-cognition-and-fear-of-falling-in-patients-with-multiple-sclerosis
#14
A Perrochon, R Holtzer, M Laidet, S Armand, F Assal, P H Lalive, G Allali
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting various neurological domains, such as postural control, cognition, fear of falling, depression-anxiety, and fatigue. This study examined the associations of cognitive functions, fear of falling, depression-anxiety, and fatigue with postural control in patients with MS. Postural control (sway velocity) of 63 patients with MS (age 39.0 ± 8.9 years; %female 57%; Expanded Disability Status Scale score median (interquartile range) 2...
December 22, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27995531/effect-on-cognition-of-estroprogestins-combined-with-interferon-beta-in-multiple-sclerosis-analysis-of-secondary-outcomes-from-a-randomised-controlled-trial
#15
Laura De Giglio, Fabiana Marinelli, Valeria T Barletta, Veronica A Pagano, Floriana De Angelis, Fulvia Fanelli, Nikolaos Petsas, Patrizia Pantano, Valentina Tomassini, Carlo Pozzilli
INTRODUCTION: Cognitive impairment is a disabling symptom in multiple sclerosis (MS). While its management remains challenging, beneficial effects on cognition of interferon beta (IFN-β) have been reported and a positive effect from estroprogestins has been hypothesised, suggesting that the combination of the two medications in women with MS could offer a promising treatment strategy. OBJECTIVES: We investigated whether a combination of estroprogestins and IFN-β can improve cognition in women with MS...
December 19, 2016: CNS Drugs
https://www.readbyqxmd.com/read/27990123/brief-rewarming-blunts-hypothermia-induced-alterations-in-sensation-motor-drive-and-cognition
#16
Marius Brazaitis, Henrikas Paulauskas, Albertas Skurvydas, Henning Budde, Laura Daniuseviciute, Nerijus Eimantas
Background: It is well known that cold exposure experienced during occupational or recreational activities may adversely affect motor, cognitive performance, and health. Most research has used prolonged passive external rewarming modalities and focused on the direct effects on the kinetics of physiological and psychological responses in hypothermic subjects. However, the brief whole body rewarming effects on physiological and psychological responses in parallel with functional consequences on cognitive and neurophysiological functions have not been investigated...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27988908/in-support-of-an-individualized-approach-to-assessing-quality-of-life-comparison-between-patient-generated-index-and-standardized-measures-across-four-health-conditions
#17
Nancy E Mayo, Ala' Aburub, Marie-Josée Brouillette, Ayse Kuspinar, Carolina Moriello, Ana Maria Rodriguez, Susan Scott
BACKGROUND: Individualized measures of health-related quality life (HRQL) have been used for decades and shown to provide unique information, but little work has been done to explain this uniqueness particularly across health conditions. AIMS: To estimate, across four health conditions, the magnitude of the association between scores derived from the Patient Generated Index (PGI) and those from fully standardized generic and disease-specific measures of the HRQL; to identify the extent to which the areas generated from the PGI are covered by the content of the fully standardized measures...
December 17, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27974947/impact-of-massage-therapy-on-fatigue-pain-and-spasticity-in-people-with-multiple-sclerosis-a-pilot-study
#18
Deborah Backus, Christine Manella, Anneke Bender, Mark Sweatman
BACKGROUND: Multiple sclerosis (MS) is a chronic, immune-mediated, inflammatory disease that leads to fatigue, pain, and spasticity, as well as other sensorimotor and cognitive changes. Often traditional medical approaches are ineffective in alleviating these disruptive symptoms. Although about one-third of surveyed individuals report they use massage therapy (MT) as an adjunct to medical treatment, there is little empirical evidence that MT is effective for symptom management in people with MS...
December 2016: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/27956834/an-observational-postmarketing-safety-registry-of-patients-in-the-uk-germany-and-switzerland-who-have-been-prescribed-sativex-%C3%A2-thc-cbd-nabiximols-oromucosal-spray
#19
Tilden Etges, Kari Karolia, Thomas Grint, Adam Taylor, Heather Lauder, Brian Daka, Stephen Wright
The global exposure of Sativex(®) (Δ(9)-tetrahydrocannabinol [THC]:cannabidiol [CBD], nabiximols) is estimated to be above 45,000 patient-years since it was given marketing approval for treating treatment-resistant spasticity in multiple sclerosis (MS). An observational registry to collect safety data from patients receiving THC:CBD was set up following its approval in the UK, Germany, and Switzerland, with the aim of determining its long-term safety in clinical practice. Twice a year, the Registry was opened to prescribing physicians to voluntarily report data on patients' use of THC:CBD, clinically significant adverse events (AEs), and special interest events...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27934122/application-of-lc-ms-based-global-metabolomic-profiling-methods-to-human-mental-fatigue
#20
Zhenling Chen, Xianfa Xu, Jianping Zhang, Yongsuo Liu, Xianggang Xu, Lili Li, Wei Wang, Haishan Xu, Wei Jiang, Yan Wang
Mental fatigue is characterized by a reduced capacity for work and a loss of capacity to respond to stimulation and is usually accompanied by a feeling of tiredness and drowsiness. Mental fatigue at work is a serious problem and can raise safety concerns especially in the transportation system. It is believed that mental fatigue is a direct or contributing cause of road and air related accidents and incidents. Psychological studies indicate that fatigue results in reduced work efficiency, alertness, and impaired mental performance...
December 6, 2016: Analytical Chemistry
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