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Fatigue and MS

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https://www.readbyqxmd.com/read/29781732/role-of-positive-lifestyle-activities-on-mood-cognition-well-being-and-disease-characteristics-in-multiple-sclerosis
#1
Lauren B Strober, Alexandra Becker, John J Randolph
Multiple sclerosis (MS) is a neurological condition associated with a wide variety of physical, cognitive, and mood-related symptoms. While disease-modifying treatment has been shown to reduce the severity and frequency of MS symptom relapses, engagement in certain daily activities holds promise as an adjunctive treatment to better manage disease sequelae. The present study sought to determine whether healthy nutritional choices, exercise, and social/intellectual engagement impacts functioning in individuals with MS...
July 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29775851/comparative-study-of-quality-of-life-anxiety-depression-and-fatigue-among-patients-with-neuromyelitis-optica-spectrum-disorder-and-multiple-sclerosis-the-first-report-from-iran
#2
Mahdi Barzegar, Shervin Badihian, Omid Mirmosayyeb, Fereshteh Ashtari, Maryam Jamadi, Shohreh Emami, Leila Jahani, Armaghan Safavi, Vahid Shaygannejad
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are associated with reduced Health Related Quality of Life (HRQOL). To the best of our knowledge, change of HRQOL in patients with NMOSD has not been yet measure in Iran. The objective of this study was to assess HRQOL in NMOSD and MS patients and identify related factors METHODS: A cross sectional study of 41 patients with NMOSD and 136 age and sex-match MS patients was performed. A series of questionnaires including Persian validated questionnaires on HRQOL (SF-36), fatigue (MFIS), depression (BDI-II), anxiety (HAM-A) and sleep quality (PSQI) were record...
April 14, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29772467/yawning-and-cortisol-levels-in-multiple-sclerosis-potential-new-diagnostic-tool
#3
Simon B N Thompson, Alister Coleman, Nicola Williams
Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had been diagnosed with multiple sclerosis. Saliva cortisol samples were collected before and after yawning or after stimuli presentation in the absence of yawning...
May 2, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29765878/effects-of-very-high-stimulation-frequency-and-wide-pulse-duration-on-stimulated-force-and-fatigue-of-quadriceps-in-healthy-participants
#4
Kitima Rongsawad, Jonjin Ratanapinunchai
Objective: To determine the effect of very high stimulation frequency (150 and 200 Hz) with wide pulse duration versus 50 Hz with wide pulse duration on stimulated force and fatigue of quadriceps femoris in healthy participants. Methods: Thirty-four healthy participants underwent fatigue test using three stimulation frequency conditions (50, 150, and 200 Hz) with pulse duration of 0.9 ms. Normalized force values at the end of each fatigue protocol and curve fitting patterns were compared among stimulated frequencies...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29763935/comorbidities-are-associated-with-altered-health-services-use-in-multiple-sclerosis-a-prospective-cohort-study
#5
Kyla A McKay, Ruth Ann Marrie, John D Fisk, Scott B Patten, Helen Tremlett
BACKGROUND: Persons with multiple sclerosis (MS) use health resources with greater frequency than the general population. However, little is known regarding which patient characteristics might contribute. OBJECTIVE: The study aimed to evaluate characteristics associated with healthcare use in MS patients. METHODS: Consecutive MS clinic attendees were recruited (September-November 2010), with clinical, demographic, and patient-completed questionnaires collected at 3 visits over 2 years...
May 15, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29761722/a-multicenter-randomized-controlled-trial-of-two-group-education-programs-for-fatigue-in-multiple-sclerosis-long-term-12-month-follow-up-at-one-site
#6
Cinda L Hugos, Michelle H Cameron, Zunqiu Chen, Yiyi Chen, Dennis Bourdette
BACKGROUND: A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months. OBJECTIVE: Assess FTC for a delayed effect on fatigue. METHODS: Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months. RESULTS: Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC -8...
May 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29756588/toward-a-shared-care-model-of-relapsing-remitting-multiple-sclerosis-role-of-the-primary-care-practitioner
#7
Jiwon Oh, Marie-Sarah Gagné-Brosseau, Melanie Guenette, Catherine Larochelle, François Lemieux, Suresh Menon, Sarah A Morrow, Laurence Poliquin-Lasnier, Chantal Roy-Hewitson, Carolina Rush, Anne-Marie Trudelle, Paul S Giacomini
The objective of this study was to develop a shared-care model to enable primary-care physicians to participate more fully in meeting the complex, multidisciplinary healthcare needs of patients with multiple sclerosis (MS). DESIGN: The design consisted of development of consensus recommendations and a shared-care algorithm. PARTICIPANTS: A working group of 11 Canadian neurologists involved in the management of patients with MS were included in this study. MAIN MESSAGE: The clinical management of patients with multiple sclerosis is increasing in complexity as new disease-modifying therapies (DMTs) become available, and ongoing safety monitoring is required...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29755590/wide-pulse-high-frequency-low-intensity-neuromuscular-electrical-stimulation-has-potential-for-targeted-strengthening-of-an-intrinsic-foot-muscle-a-feasibility-study
#8
Darren C James, Matthew C Solan, Katya N Mileva
Background: Strengthening the intrinsic foot muscles is a poorly understood and largely overlooked area. In this study, we explore the feasibility of strengthening m . abductor hallucis (AH) with a specific paradigm of neuromuscular electrical stimulation; one which is low-intensity in nature and designed to interleave physiologically-relevant low frequency stimulation with high-frequencies to enhance effective current delivery to spinal motoneurones, and enable a proportion of force produced by the target muscle to be generated from a central origin...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29752033/effectiveness-of-monopolar-dielectric-transmission-of-pulsed-electromagnetic-fields-for-multiple-sclerosis-related-pain-a-pilot-study
#9
A Hochsprung, S Escudero-Uribe, A J Ibáñez-Vera, G Izquierdo-Ayuso
INTRODUCTION: Pain is highly prevalent in patients with multiple sclerosis (MS); it is chronic in 50% of cases and is classified as nociceptive, neuropathic, or mixed-type. Pain affects quality of life, sleep, and the activities of daily living. Electrotherapy is an interesting alternative or complementary treatment in the management of pain in MS, with new innovations constantly appearing. MATERIAL AND METHODS: This study evaluates the effectiveness of treatment with monopolar dielectric transmission of pulsed electromagnetic fields (PEMF) for pain associated with MS...
May 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29748959/changes-in-intestinal-microbiota-affect-metabolism-of-ginsenoside-re
#10
Lei Zhang, Fei Li, Wang-Jun Qin, Chao Fu, Xiang-Lin Zhang
Ginsenoside Re, an active ingredient in Panax ginseng, is widely used as a therapeutic and nutriment. Intestinal microbiota plays crucial roles in modulating the pharmacokinetics and pharmacological actions of ginsenoside Re. The aim of this study was to explore the relationship between bacterial community variety and the metabolic profiles of ginsenoside Re. We developed two models with intestinal dysbacteriosis: a pseudo-germ-free model induced by a non-absorbable antimicrobial mixture (ATM), and Qi-deficiency model established via over-fatigue and acute cold stress (OACS)...
May 10, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29741962/the-multiple-sclerosis-work-difficulties-questionnaire-translation-and-cross-cultural-adaptation-to-turkish-and-assessment-of-validity-and-reliability
#11
Turhan Kahraman, Asiye Tuba Özdoğar, Cynthia Alison Honan, Özge Ertekin, Serkan Özakbaş
PURPOSE: To linguistically and culturally adapt the Multiple Sclerosis Work Difficulties Questionnaire-23 (MSWDQ-23) for use in Turkey, and to examine its reliability and validity. METHODS: Following standard forward-back translation of the MSWDQ-23, it was administered to 124 people with multiple sclerosis (MS). Validity was evaluated using related outcome measures including those related to employment status and expectations, disability level, fatigue, walking, and quality of life...
May 9, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29740872/prodromal-symptoms-of-multiple-sclerosis-in-primary-care
#12
Giulio Disanto, Chiara Zecca, Sharon MacLachlan, Rosaria Sacco, Lahiru Handunnetthi, Ute C Meier, Alex Simpson, Laura McDonald, Andrea Rossi, Pascal Benkert, Jens Kuhle, Sreeram V Ramagopalan, Claudio Gobbi
OBJECTIVE: Early diagnosis and treatment initiation significantly influence long term disability outcome in multiple sclerosis (MS). We aimed at identifying prodromal symptoms of MS in primary care settings. METHODS: This was a nested case-control study comparing the occurrence of various symptoms in MS patients vs controls at 0-2, 2-5 and 5-10 years before index date (first MS record). A total of 10,204 incident MS cases were identified within the UK Clinical Practice Research Datalink (CPRD) between 01/01/1987 and 28/02/2016 (median (IQR) age=47 (39-57) years, females=7,308 (71...
May 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29720222/targeted-lipidomics-analysis-identified-altered-serum-lipid-profiles-in-patients-with-polymyositis-and-dermatomyositis
#13
Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E Lundberg, Marina Korotkova
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and immunosuppressive drugs; however, few patients recover full muscle function. One explanation of the persistent muscle weakness could be altered lipid metabolism in PM/DM muscle tissue as we previously reported. Using a targeted lipidomic approach we aimed to characterize serum lipid profiles in patients with PM/DM compared to healthy individuals (HI) in a cross-sectional study...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29705497/presynaptic-inhibition-mechanisms-may-subserve-the-spinal-excitability-modulation-induced-by-neuromuscular-electrical-stimulation
#14
Sidney Grosprêtre, Nicolas Gueugneau, Alain Martin, Romuald Lepers
This study aimed at deciphering the origins of spinal excitability modulation that follows neuromuscular electrical stimulation (NMES). Ten participants (age: 24.6 ± 4.2 years) performed 2 randomized NMES sessions on plantar flexors with frequencies of stimulations of 20 or 100 Hz (pulse width: 1 ms) at 20% of maximal voluntary contraction (MVC). Before and after each session, the posterior tibial nerve was stimulated to record H-reflex of soleus (SOL), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)...
April 24, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29703519/proteomics-and-immunohistochemistry-identify-the-expression-of-%C3%AE-cardiac-myosin-heavy-chain-in-the-jaw-closing-muscles-of-sooty-mangabeys-order-primates
#15
Christine E Wall, Megan Holmes, Erik J Soderblom, Andrea B Taylor
OBJECTIVE: The jaw-closing muscles of humans and nonprimate mammals express alpha-cardiac fibers but MyHC α-cardiac has not been identified in the jaw adductors of nonhuman primates. We determined whether MyHC α-cardiac is expressed in the superficial masseter and temporalis muscles of the sooty mangabey (Cercocebus atys), an African Old World monkey that specializes on hard seeds. DESIGN: LC-MS/MS based proteomics was used to identify the presence of MyHC Iα...
February 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29697757/daily-temporal-associations-between-physical-activity-and-symptoms-in-multiple-sclerosis
#16
Anna L Kratz, Nora E Fritz, Tiffany J Braley, Eric L Scott, Emily Foxen-Craft, Susan L Murphy
Background: Symptom severity is negatively associated with physical activity in multiple sclerosis (MS). However, it is unclear how physical activity and symptoms correlate on a day-to-day basis in persons with MS. Purpose: To determine the temporal within-person associations of pain, fatigue, depressed mood, and perceived cognitive function with physical activity in MS. Methods: Ambulatory adults with MS (N = 107) completed 7 days of home monitoring...
April 25, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29685406/evaluation-of-reproductive-health-in-female-patients-with-multiple-sclerosis-in-polish-population
#17
Paweł Bartnik, Aleksandra Wielgoś, Joanna Kacperczyk-Bartnik, Iwona Szymusik, Aleksandra Podlecka-Piętowska, Beata Zakrzewska-Pniewska, Mirosław Wielgoś
Multiple sclerosis (MS) is a chronic disease, which affects mostly women and has an early onset. Due to progress in treatment patients maintain a high quality of life for a long period and participate in all of its fields. One of them is reproductive health with all of its aspects. The aim of the study was to evaluate the reproductive health of female MS patients with regard to various features of MS. It was a cross-sectional study. The data was collected via anonymous survey distributed among patients with MS hospitalized at the Department of Neurology, Medical University of Warsaw and online...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29680460/effects-of-hippotherapy-in-multiple-sclerosis-pilot-study-on-quality-of-life-spasticity-gait-pelvic-floor-depression-and-fatigue
#18
Susana Muñoz-Lasa, Carlos López de Silanes, M Ángeles Atín-Arratibel, Carmen Bravo-Llatas, Salvador Pastor-Jimeno, Nuria Máximo-Bocanegra
INTRODUCTION AND OBJECTIVE: Hippotherapy is being used as a promising method in the physical treatment of multiple sclerosis (MS). MATERIAL AND METHOD: Comparative open clinical pre-post study into hippotherapy intervention during a 6-month period in patients with MS (n=6). Not randomised and with control group (n=4). The study was performed by MHG Foundation. RESULTS: A statistically significant improvement was observed in the therapy group in: spasticity pre-post measured by the modified Ashworth scale (P=...
April 19, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29672097/cognitive-and-affective-mechanisms-of-pain-and-fatigue-in-multiple-sclerosis
#19
Anne Arewasikporn, Aaron P Turner, Kevin N Alschuler, Abbey J Hughes, Dawn M Ehde
OBJECTIVE: To examine the extent to which pain catastrophizing, fatigue catastrophizing, positive affect, and negative affect simultaneously mediated the associations between common symptoms of multiple sclerosis (MS; i.e., pain, fatigue) and impact on daily life, depressive symptoms, and resilience. METHOD: Participants were community-dwelling adults with MS (N = 163) reporting chronic pain, fatigue, and/or moderate depressive symptoms. Multiple mediation path analysis was used to model potential mediators of pain and fatigue separately, using baseline data from a randomized controlled trial comparing two symptom self-management interventions...
April 19, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29671103/role-of-ca-2-in-changing-active-force-during-intermittent-submaximal-stimulation-in-intact-single-mouse-muscle-fibers
#20
Lisa D Glass, Arthur J Cheng, Brian R MacIntosh
Fatigue of single mouse fibers during repeated high-frequency stimulation results initially from decreased Ca2+ sensitivity while free myoplasmic calcium concentration ([Ca2+ ]m ) increases, followed by decreasing [Ca2+ ]m . Recovery of active force with low-frequency stimulation is slow and persistent fatigue results from low [Ca2+ ]m . However, the consequences of intermittent submaximal contractions are not known. The aim of the present study was to investigate the changes in [Ca2+ ]m and active force during intermittent submaximal contractions and subsequent recovery...
April 18, 2018: Pflügers Archiv: European Journal of Physiology
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