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Fatigue and MS

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https://www.readbyqxmd.com/read/28805691/structural-and-neuronal-integrity-measures-of-fatigue-severity-in-multiple-sclerosis
#1
Evanthia Bernitsas, Kalyan Yarraguntla, Fen Bao, Rishi Sood, Carla Santiago-Martinez, Rajkumar Govindan, Omar Khan, Navid Seraji-Bozorgzad
Fatigue is a common and disabling symptom in Multiple Sclerosis (MS). However, consistent neuroimaging correlates of its severity are not fully elucidated. In this article, we study the neuronal correlates of fatigue severity in MS. Forty-three Relapsing Remitting MS (RRMS) patients with MS-related fatigue (Fatigue Severity Scale (FSS) range: 1-7) and Expanded Disability Status Scale (EDSS) ≤ 4, were divided into high fatigue (HF, FSS ≥ 5.1) and low fatigue groups (LF, FSS ≤ 3). We measured T2 lesion load using a semi-automated technique...
August 12, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28789787/relationship-between-perceived-fatigue-and-performance-fatigability-in-people-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#2
REVIEW
Bryan D Loy, Ruby L Taylor, Brett W Fling, Fay B Horak
BACKGROUND: Perceived fatigue (i.e., subjective perception of reduced capacity) is one of the most common and disabling symptoms for people with multiple sclerosis (MS). Perceived fatigue may also be related to performance fatigability (i.e., decline in physical performance over time), although study findings have been inconsistent. OBJECTIVE: To locate all studies reporting the relationship between perceived fatigue and fatigability in people with MS, determine the population correlation, and examine moderating variables of the correlation size...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28782878/physiological-measures-in-participants-with-chronic-fatigue-syndrome-multiple-sclerosis-and-healthy-controls-following-repeated-exercise-a-pilot-study
#3
L D Hodges, T Nielsen, D Baken
PURPOSE: To compare physiological responses of chronic fatigue syndrome (CFS/ME), multiple sclerosis (MS) and healthy controls (HC) following a 24-h repeated exercise test. METHODS: Ten CFS, seven MS and 17 age- and gender-matched healthy controls (10, CFS HC; and seven, MS HC) were recruited. Each participant completed a maximal incremental cycle exercise test on day 1 and again 24 h later. Heart rate (HR), blood pressure (BP), rating of perceived exertion (RPE), oxygen consumption (V˙O2), carbon dioxide production and workload (WL) were recorded...
August 7, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28777363/-sleep-disturbances-an-important-factor-in-combination-minor-symptoms-of-multiple-sclerosis
#4
E Z Yakupov, Yu V Troshina
AIM: To investigate the clinical and neurophysiological features of sleep disorders in patients with different forms of multiple sclerosis (MS) and their impact on life quality, dynamic and prognosis of the disease. Identify the impact of sleep disorders on the formation and maintenance of chronic fatigue syndrome in patients with MS. MATERIAL AND METHODS: General clinical methods of examination like neuropsychological testing (definition of anxiety and depression), the scales of the subjective determination of the quality of sleep, the severity of daytime sleepiness, quality of life, severity of chronic fatigue syndrome) and their subsequent correlation with neuroimaging and neurophysiological data were studied...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28770664/hippotherapy-for-patients-with-multiple-sclerosis-a-multicenter-randomized-controlled-trial-ms-hippo
#5
Vanessa Vermöhlen, Petra Schiller, Sabine Schickendantz, Marion Drache, Sabine Hussack, Andreas Gerber-Grote, Dieter Pöhlau
BACKGROUND: Evidence-based complementary treatment options for multiple sclerosis (MS) are limited. OBJECTIVE: To investigate the effect of hippotherapy plus standard care versus standard care alone in MS patients. METHODS: A total of 70 adults with MS were recruited in five German centers and randomly allocated to the intervention group (12 weeks of hippotherapy) or the control group. Primary outcome was the change in the Berg Balance Scale (BBS) after 12 weeks, and further outcome measures included fatigue, pain, quality of life, and spasticity...
August 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28770449/randomized-trial-of-vitamin-d3-to-prevent-worsening-of-musculoskeletal-symptoms-in-women-with-breast-cancer-receiving-adjuvant-letrozole-the-vital-trial
#6
Qamar J Khan, Bruce F Kimler, Pavan S Reddy, Priyanka Sharma, Jennifer R Klemp, Jennifer L Nydegger, Hung-Wen Yeh, Carol J Fabian
PURPOSE: Aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) frequently occur in women being treated for breast cancer. Prior studies suggest high prevalence of vitamin D deficiency in breast cancer patients with musculoskeletal (MS) pain. We conducted a randomized, placebo-controlled trial to determine if 30,000 IU vitamin D3 per week (VitD3) would prevent worsening of AIMSS in women starting adjuvant letrozole for breast cancer. METHODS: Women with stage I-III breast cancer starting adjuvant letrozole and 25(OH)D level ≤40 ng/ml were eligible...
August 2, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28766982/serum-met-5-enkephalin-levels-are-reduced-in-multiple-sclerosis-and-restored-by-low-dose-naltrexone
#7
Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin
Low-dose naltrexone is a widely used off-label therapeutic prescribed for a variety of immune-related disorders. The mechanism underlying low-dose naltrexone's efficacy for fatigue, Crohn's disease, fibromyalgia, and multiple sclerosis is, in part, intermittent blockade of opioid receptors followed by upregulation of endogenous opioids. Short, intermittent blockade by naltrexone specifically blocks the opioid growth factor receptor resulting in biofeedback events that increase production of the endogenous opioid growth factor (OGF) (chemically termed [Met(5)]-enkephalin) facilitating interactions between opioid growth factor and opioid growth factor receptor that ultimately, result in inhibited cell proliferation...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28764994/alexithymia-in-multiple-sclerosis-a-systematic-review-of-literature
#8
REVIEW
Moussa A Chalah, Samar S Ayache
BACKGROUND: Alexithymia is a multidimensional personality construct characterized by difficulties identifying and describing one's feelings, and externally oriented thinking. Although extensively reported in psychiatric patients, little attention has been paid regarding its occurrence and its pathophysiology in the context of multiple sclerosis (MS). METHODS: A research was conducted according to the PRISMA guidelines aiming to identify original research articles in English and French languages about alexithymia in MS...
July 29, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28756744/personalized-bilateral-whole-body-somatosensory-cortex-stimulation-to-relieve-fatigue-in-multiple-sclerosis
#9
Andrea Cancelli, Carlo Cottone, Alessandro Giordani, Simone Migliore, Domenico Lupoi, Camillo Porcaro, Massimiliano Mirabella, Paolo Maria Rossini, Maria Maddalena Filippi, Franca Tecchio
BACKGROUND: The patients suffering from multiple sclerosis (MS) often consider fatigue the most debilitating symptom they experience, but conventional medicine currently offers poorly efficacious therapies. OBJECTIVE: We executed a replication study of an innovative approach for relieving MS fatigue. METHODS: According to the sample size estimate, we recruited 10 fatigued MS patients who received 5-day transcranial direct current stimulation (tDCS) in a randomized, double-blind, Sham-controlled, crossover study, with modified Fatigue Impact Scale (mFIS) score reduction at the end of the treatment as primary outcome...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28755683/sulbutiamine-shows-promising-results-in-reducing-fatigue-in-patients-with-multiple-sclerosis
#10
Serhan Sevim, Hakan Kaleağası, Bahar Taşdelen
BACKGROUND: Fatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS). There are no available effective therapies for fatigue associated with MS, and it is unclear whether a successful therapy of MS leads to clinical improvement. Sulbutiamine is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Whereas several clinical trials have demonstrated the beneficial effects of sulbutiamine in patients with asthenia, there have been no reports on the effects of sulbutiamine on fatigue in patients with MS...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28755682/the-effect-of-exercise-training-in-adults-with-multiple-sclerosis-with-severe-mobility-disability-a-systematic-review-and-future-research-directions
#11
REVIEW
Thomas Edwards, Lara A Pilutti
INTRODUCTION: There is evidence for the benefits of exercise training in persons with multiple sclerosis (MS). However, these benefits have primarily been established in individuals with mild-to-moderate disability (i.e., Expanded Disability Status Scale [EDSS] scores 1.0-5.5), rather than among those with significant mobility impairment. Further, the approaches to exercise training that have been effective in persons with mild-to-moderate MS disability may not be physically accessible for individuals with mobility limitations...
August 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28750174/cognitive-fatigue-an-impaired-cortical-inhibitory-replenishment
#12
Claude Touzet
PRIMARY OBJECTIVE: The present study explores the cause of cognitive fatigue in persons with traumatic brain injury (TBI), as also in persons with Multiple Sclerosis (MS). Since cognitive fatigue shares many symptoms with chronic sleep deprivation (best described as cumulative excess wakefulness), it was hypothesized that cognitive fatigue is caused by cumulative excess wakefulness because of an impaired sleep efficacy. Recent results about the nature of sleep advocate that sleep aims primarily to replenish the efficiency of cortical inhibitory synapses...
July 27, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28735833/cannabis-use-in-people-with-parkinson-s-disease-and-multiple-sclerosis-a-web-based-investigation
#13
John H Kindred, Kaigang Li, Nathaniel B Ketelhut, Felix Proessl, Brett W Fling, Justin M Honce, William R Shaffer, Thorsten Rudroff
OBJECTIVES: Cannabis has been used for medicinal purpose for thousands of years; however the positive and negative effects of cannabis use in Parkinson's disease (PD) and Multiple Sclerosis (MS) are mostly unknown. Our aim was to assess cannabis use in PD and MS and compare results of self-reported assessments of neurological disability between current cannabis users and non-users. METHODS: An anonymous web-based survey was hosted on the Michael J. Fox Foundation and the National Multiple Sclerosis Society webpages from 15 February to 15 October 2016...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28735720/a-randomized-controlled-trial-to-examine-the-impact-of-aquatic-exercise-training-on-functional-capacity-balance-and-perceptions-of-fatigue-in-female-patients-with-multiple-sclerosis
#14
Mehdi Kargarfard, Ardalan Shariat, Lee Ingle, Joshua A Cleland, Mina Kargarfard
OBJECTIVE: To assess the effects of 8-weeks aquatic exercise training program on functional capacity, balance, and perceptions of fatigue in women with multiple sclerosis (MS). DESIGN: A randomized controlled design. SETTING: Referral center of a multiple sclerosis society. PARTICIPANTS: Women (age: 36.4 ±8.2) diagnosed with relapsing-remitting (RR-type) MS. After undergoing baseline testing by a neurologist, participants were allocated to either an intervention (aquatic training program) or a control group...
July 20, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28729945/validity-and-reliability-of-the-fatigue-severity-scale-in-finnish-multiple-sclerosis-patients
#15
Eija Rosti-Otajärvi, Päivi Hämäläinen, Anna Wiksten, Tanja Hakkarainen, Juhani Ruutiainen
BACKGROUND: Fatigue is one of the most debilitating symptoms in multiple sclerosis (MS) considerably interfering with patients' daily functioning. Both researchers and clinicians need psychometrically robust methods to evaluate fatigue in MS. OBJECTIVES: The objective of this study was (i) to evaluate the psychometric properties of the Finnish version of the Fatigue Severity Scale (FSS) and (ii) to describe the results among patients with MS. METHODS: In total, 553 patients with MS (mean age, 53...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729932/validity-and-reliability-of-the-finnish-version-of-the-multiple-sclerosis-impact-scale-29
#16
Eija Rosti-Otajärvi, Päivi Hämäläinen, Anna Wiksten, Tanja Hakkarainen, Juhani Ruutiainen
BACKGROUND: The Multiple Sclerosis Impact Scale-29 (MSIS-29) has been increasingly used to evaluate the self-perceived impact of multiple sclerosis (MS) on a patient. OBJECTIVES: The aim of this study was to evaluate the psychometric properties of the Finnish version of MSIS-29 in patients with MS. METHODS: A total of 553 patients with MS completed the MSIS-29 and self-administered questionnaires capturing information on demographics, disease characteristics and severity, perceived quality of life (EuroQol 5D-3L instrument), and fatigue (Fatigue Severity Scale)...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729927/fatigue-and-cognition-pupillary-responses-to-problem-solving-in-early-multiple-sclerosis-patients
#17
Sigrid A de Rodez Benavent, Gro O Nygaard, Hanne F Harbo, Siren Tønnesen, Piotr Sowa, Nils I Landrø, Marte Wendel-Haga, Lars Etholm, Kristian B Nilsen, Liv Drolsum, Emilia Kerty, Elisabeth G Celius, Bruno Laeng
INTRODUCTION: In early multiple sclerosis (MS) patients, cognitive changes and fatigue are frequent and troublesome symptoms, probably related to both structural and functional brain changes. Whether there is a common cause of these symptoms in MS is unknown. In theory, an altered regulation of central neuropeptides can lead to changes in regulation of autonomic function, cognitive difficulties, and fatigue. Direct measurements of central neuropeptides are difficult to perform, but measurements of the eye pupil can be used as a reliable proxy of function...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729170/how-do-pain-fatigue-depressive-and-cognitive-symptoms-relate-to-well-being-and-social-and-physical-functioning-in-the-daily-lives-of-individuals-with-multiple-sclerosis
#18
Anna L Kratz, Tiffany J Braley, Emily Foxen-Craft, Eric Scott, John Murphy, Susan L Murphy
OBJECTIVE: To examine the relative association between daily change in pain, fatigue, depressed mood, and cognitive function, and four outcomes (positive affect and well-being, ability to participate in social roles and activities, upper extremity (UE) functioning, and lower extremity (LE) functioning). DESIGN: Repeated-measures observational study including a baseline lab visit, followed by seven days of home monitoring that included ecological momentary assessment (EMA) of symptoms (pain, fatigue, depressed mood, and cognitive function) and end-of-day diary surveys of outcomes of interest...
July 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28729169/pain-fatigue-and-cognitive-symptoms-are-temporally-associated-within-but-not-across-days-in-multiple-sclerosis
#19
Anna L Kratz, Susan L Murphy, Tiffany J Braley
OBJECTIVE: To examine the temporal associations, within-day and day-to-day, between pain, fatigue, depressed mood, and cognitive function in multiple sclerosis (MS). DESIGN: Repeated-measures study involving seven days of ecological momentary assessment (EMA) of symptoms five times a day. Multilevel mixed models were used to analyze data. SETTING: Community. PARTICIPANTS: Ambulatory adults (N=107) with MS. INTERVENTIONS: Not applicable...
July 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28729168/ecological-momentary-assessment-of-pain-fatigue-depressive-and-cognitive-symptoms-reveals-significant-daily-variability-in-multiple-sclerosis
#20
Anna L Kratz, Susan L Murphy, Tiffany J Braley
OBJECTIVE: To describe the daily variability and patterns of pain, fatigue, depressed mood, and cognitive function in persons with multiple sclerosis (MS). DESIGN: Repeated-measures observational study of seven consecutive days of home monitoring, including ecological momentary assessment (EMA) of symptoms. Multilevel mixed models were used to analyze data. SETTING: General community. PARTICIPANTS: Ambulatory adults (N=107) with MS recruited through [Masked] and surrounding community...
July 17, 2017: Archives of Physical Medicine and Rehabilitation
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