keyword
https://read.qxmd.com/read/38505558/fecal-microbiota-colonization-dynamics-in-dairy-heifers-associated-with-early-life-rumen-microbiota-modulation-and-gut-health
#21
JOURNAL ARTICLE
Hanna Huuki, Johanna Vilkki, Aila Vanhatalo, Ilma Tapio
Early-life modulation of rumen microbiota holds promise for enhancing calf growth, health, and long-term production in ruminants. However, limited attention has been given to the impact of rumen microbiota modulation on the establishment of hindgut microbiota. In this study, fecal microbiota development was examined in identical twin calves for 12 months. The treatment group (T-group) received adult cow fresh rumen liquid inoculum during the pre-weaning period, while the control group did not (C-group)...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38503922/human-lung-cancer-harbors-spatially-organized-stem-immunity-hubs-associated-with-response-to-immunotherapy
#22
JOURNAL ARTICLE
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela Shih, Moshe Sade-Feldman, Genevieve M Boland, Karin Pelka, Martin J Aryee, Mari Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade. Critically, we discovered the stem-immunity hub, a subtype of immunity hub strongly associated with favorable PD-1-blockade outcome...
March 19, 2024: Nature Immunology
https://read.qxmd.com/read/38503395/a-single-bout-of-vigorous-intensity-exercise-enhances-the-efficacy-of-rituximab-against-autologous-human-chronic-lymphocytic-leukaemia-b-cells-ex-vivo
#23
JOURNAL ARTICLE
Harrison D Collier-Bain, Annabelle Emery, Adam J Causer, Frankie F Brown, Rebecca Oliver, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Shoji Leach, Rachel Eddy, Daniela Rothschild-Rodriguez, Juliet C Gray, Mark S Cragg, Kirstie L Cleary, Sally Moore, James Murray, James E Turner, John P Campbell
Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in survival niches may be due to several factors including low NK-cell frequency and a suppressive stromal environment that promotes CLL cell survival...
March 17, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38501278/phase-out-planning-for-animal-experimentation
#24
JOURNAL ARTICLE
Anne Gourmelon, Philippe Hubert, Elise Grignard, Lisa Baumann, Sharon Munn, Cécile Michel
The 4th Annual Forum on Endocrine Disrupters organized by the European Commission brought together authors of this article around the topic: "From bench to validated test guidelines: (pre)validation of test methods". Validation activities are meant to demonstrate the relevance and reliability of methods and approaches used in regulatory safety testing. These activities are essential to facilitate regulatory use, still they are largely underfunded and unattractive to the scientific community. In the last decade, there has been large amounts of funding invested in European research towards the development of approaches that can be used in regulatory decision-making, including for the identification of endocrine disrupters...
March 19, 2024: ALTEX
https://read.qxmd.com/read/38500146/updated-single-cell-reference-atlas-for-the-starlet-anemone-nematostella-vectensis
#25
JOURNAL ARTICLE
Alison G Cole, Julia Steger, Julia Hagauer, Andreas Denner, Patricio Ferrer Murguia, Paul Knabl, Sanjay Narayanaswamy, Brittney Wick, Juan D Montenegro, Ulrich Technau
BACKGROUND: The recent combination of genomics and single cell transcriptomics has allowed to assess a variety of non-conventional model organisms in much more depth. Single cell transcriptomes can uncover hidden cellular complexity and cell lineage relationships within organisms. The recent developmental cell atlases of the sea anemone Nematostella vectensis, a representative of the basally branching Cnidaria, has provided new insights into the development of all cell types (Steger et al Cell Rep 40(12):111370, 2022; Sebé-Pedrós et al...
March 18, 2024: Frontiers in Zoology
https://read.qxmd.com/read/38497787/acute-pre-and-post-competitive-soccer-match-play-changes-in-neuromuscular-factors-physical-performance-and-muscle-response-in-youth-male-players
#26
JOURNAL ARTICLE
Imanol Martin-Garetxana, Jonathan Hughes, Mark De Ste Croix, Jon Larruskain, Jose A Lekue, Francisco Ayala
There is a paucity of literature analyzing the impact of fatigue from actual competitive soccer match-play on measures of neuromuscular function and muscle damage markers in youth players. Aims The main purpose was to analyze the acute pre- and post-competitive soccer match-play changes in measures of landing mechanics, stretch-shortening cycle capability, physical performance, muscle damage, and match intensity. A secondary purpose was to explore whether the players' maturity status and chronological age were associated with post-soccer match-play responses...
March 18, 2024: Science & medicine in football
https://read.qxmd.com/read/38496550/establishment-of-h3k9me3-is-influenced-by-genomic-context-and-is-temporally-uncoupled-from-signal-growth-during-early-zebrafish-embryogenesis
#27
Katherine L Duval, Ashley R Artis, Mary G Goll
The structural organization of eukaryotic genomes is contingent upon the fractionation of DNA into transcriptionally active euchromatin and repressive heterochromatin. However, we have a limited understanding of how these distinct states are first established during animal embryogenesis. Histone 3 lysine 9 trimethylation (H3K9me3) is critical to heterochromatin formation and bulk establishment of this mark is thought to help drive large-scale remodeling of an initially naive chromatin state during animal embryogenesis...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38495131/effect-of-rituximab-on-immune-status-in-children-with-aggressive-mature-b-cell-lymphoma-leukemia-a-prospective-study-from-cccg-bnhl-2015
#28
JOURNAL ARTICLE
Jiajia Dong, Zhou Xu, Xia Guo, Fanghua Ye, Chenying Fan, Ju Gao, Yijin Gao, Liangchun Yang
BACKGROUND: Limited research has been conducted on the impact of rituximab on immune function and the incidence of side effects in children undergoing combination chemotherapy for aggressive mature B-cell lymphoma/leukemia. METHODS: Clinical data from 85 patients with primary pediatric aggressive mature B-cell lymphoma/leukemia, treated according to the Chinese Children's Cancer Group (CCCG)-mature B-cell non-Hodgkin lymphoma (BNHL)-2015 protocol from June 1, 2015, to December 1, 2022, were collected from three tertiary medical centers in China...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38492973/infant-mismatch-responses-to-speech-sound-changes-predict-language-development-in-preschoolers-at-risk-for-dyslexia
#29
JOURNAL ARTICLE
Sergio Navarrete-Arroyo, Paula Virtala, Peixin Nie, Linda Kailaheimo-Lönnqvist, Satu Salonen, Teija Kujala
OBJECTIVE: We investigated how infant mismatch responses (MMRs), which have the potential for providing information on auditory discrimination abilities, could predict subsequent development of pre-reading skills and the risk for familial dyslexia. METHODS: We recorded MMRs to vowel, duration, and frequency deviants in pseudo-words at birth and 28 months in a sample over-represented by infants with dyslexia risk. We examined MMRs' associations with pre-reading skills at 28 months and 4-5 years and compared the results in subgroups with vs...
March 5, 2024: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://read.qxmd.com/read/38490977/autophagy-regulates-the-maturation-of-hematopoietic-precursors-in-the-embryo
#30
JOURNAL ARTICLE
Yumin Liu, Linjuan Shi, Yifan Chen, Sifan Luo, Yuehang Chen, Hongtian Chen, Wenlang Lan, Xun Lu, Zhan Cao, Zehua Ye, Jinping Li, Bo Yu, Elaine Dzierzak, Zhuan Li
An understanding of the mechanisms regulating embryonic hematopoietic stem cell (HSC) development would facilitate their regeneration. The aorta-gonad-mesonephros region is the site for HSC production from hemogenic endothelial cells (HEC). While several distinct regulators are involved in this process, it is not yet known whether macroautophagy (autophagy) plays a role in hematopoiesis in the pre-liver stage. Here, we show that different states of autophagy exist in hematopoietic precursors and correlate with hematopoietic potential based on the LC3-RFP-EGFP mouse model...
March 15, 2024: Nature Communications
https://read.qxmd.com/read/38489006/a-repertoire-of-intronic-lariat-rnas-reveals-tissue-specific-regulation-and-target-mimicry-potential-in-plants
#31
JOURNAL ARTICLE
Yong Zhang, Xiaotuo Zhang, Qi Tang, Lei Li, Ting Jiang, Yixiao Fang, Hong Zhang, Jixian Zhai, Guodong Ren, Binglian Zheng
Lariat RNA is concomitantly produced by excised intron during RNA splicing, which is usually debranched by DBR1, an RNA debranching enzyme. However, increasing evidence showed that some lariat RNA could escape debranching. Little is known about how and why these lariat RNAs could be retained. By comparing the atlas of lariat RNAs between the non-dividing cell (mature pollen) and three actively dividing tissues (young shoot apex, young seeds, and young roots), we identified hundreds to thousands of lariat RNA naturally retained in each tissue, and the incidence of lariat RNA retention is much less in shoot apex while much more in pollen...
March 12, 2024: Science China. Life Sciences
https://read.qxmd.com/read/38487536/intratumoral-cxcr4-hi-neutrophils-display-ferroptotic-and-immunosuppressive-signatures-in-hepatoblastoma
#32
JOURNAL ARTICLE
Zhengjing Lu, Xiaolin Wang, Jun Feng, Wenjia Chai, Wei Wang, Qixin Wang, Shen Yang, Wei Yang, Yan Su, Wenjun Mou, Yun Peng, Huanmin Wang, Jingang Gui
Pediatric hepatoblastoma (HB) is the most common primary liver malignancy in infants and children. With great diversity and plasticity, tumor-infiltrating neutrophils were one of the most determining factors for poor prognosis in many malignant tumors. In this study, through bulk RNA sequencing for sorted blood and tumor-infiltrated neutrophils and comparison of neutrophils in tumor and para-tumor tissue by single-cell sequencing, we found that intratumoral neutrophils were composed of heterogenous functional populations at different development stages...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38485977/follicular-challenge-test-to-predict-suboptimal-response-to-gonadotropin-releasing-hormone-agonist-trigger-in-elective-oocyte-cryopreservation-cycles
#33
JOURNAL ARTICLE
Sarit Avraham, Michal Youngster, Gil Yerushalmi, Yekaterina Belov, Itai Gat, Alon Kedem, Odelia Yaakov, Yariv Gidoni, Jonathan Barkat, Ohad Baruchin, Ariel Hourvitz
This prospective study aimed to test the ability of follicular GnRH agonist challenge test (FACT) to predict suboptimal response to GnRH agonist trigger, assessed by LH levels post ovulation trigger in non-medical oocyte cryopreservation program. The study included 91 women that underwent non-medical fertility preservation. On day two to menstrual cycle, blood tests were drawn (basal Estradiol, basal FSH, basal LH, Progesterone) and ultrasound (US) was performed. On that evening, the women were instructed to inject 0...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38481211/correlation-between-pulp-sensibility-and-magnetic-resonance-signal-intensity-following-regenerative-endodontic-procedures-in-mature-necrotic-teeth-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Noha Mohamed El-Kateb, Amr Mohamed Abdallah, Rania Noaman ElBackly
BACKGROUND: With increasing studies being published on regenerative endodontic procedures (REPs) as a treatment modality for mature necrotic teeth, the assessment of outcomes following regenerative endodontic procedures has become more challenging and the demand for a better understanding of the regenerated tissues following this treatment is rising. The study aimed to correlate cold, electric pulp testing (EPT), and magnetic resonance imaging (MRI) signal intensity (SI) in mature necrotic teeth treated with regenerative endodontic procedures...
March 13, 2024: BMC Oral Health
https://read.qxmd.com/read/38479802/multiple-structural-flavors-of-rnase-p-in-precursor-trna-processing
#35
REVIEW
Sagar Sridhara
The precursor transfer RNAs (pre-tRNAs) require extensive processing to generate mature tRNAs possessing proper fold, structural stability, and functionality required to sustain cellular viability. The road to tRNA maturation follows an ordered process: 5'-processing, 3'-processing, modifications at specific sites, if any, and 3'-CCA addition before aminoacylation and recruitment to the cellular protein synthesis machinery. Ribonuclease P (RNase P) is a universally conserved endonuclease in all domains of life, performing the hydrolysis of pre-tRNA sequences at the 5' end by the removal of phosphodiester linkages between nucleotides at position -1 and +1...
2024: Wiley Interdisciplinary Reviews. RNA
https://read.qxmd.com/read/38478847/3d-bioprinted-human-skin-model-recapitulating-native-like-tissue-maturation-and-immunocompetence-as-an-advanced-platform-for-skin-sensitization-assessment
#36
JOURNAL ARTICLE
Bibrita Bhar, Eshani Das, Kodieswaran Manikumar, Biman B Mandal
Physiologically-relevant in vitro skin models hold utmost importance for efficacy assessments of pharmaceutical and cosmeceutical formulations, offering valuable alternatives to animal testing. Here, we present an advanced immunocompetent three-dimensional (3D) bioprinted human skin model to assess skin sensitization. Initially, a photopolymerizable bioink is formulated using silk fibroin methacrylate, gelatin methacrylate, and photoactivated human platelet releasate. The developed bioink shows desirable physicochemical and rheological attributes for microextrusion bioprinting...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38476116/itpr2-mediated-calcium-homeostasis-in-oligodendrocytes-is-essential-for-myelination-and-involved-in-depressive-like-behavior-in-adolescent-mice
#37
JOURNAL ARTICLE
Ming Zhang, Na Zhi, Jiaxiang Feng, Yingqi Liu, Meixia Zhang, Dingxi Liu, Jie Yuan, Yuhao Dong, Sufang Jiang, Junye Ge, Shengxi Wu, Xianghui Zhao
Ca2+ signaling is essential for oligodendrocyte (OL) development and myelin formation. Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) is an endoplasmic reticulum calcium channel and shows stage-dependent high levels in postmitotic oligodendrocyte precursor cells (OPCs). The role and potential mechanism of ITPR2 in OLs remain unclear. In this study, it is revealed that loss of Itpr2 in OLs disturbs Ca2+ homeostasis and inhibits myelination in adolescent mice. Animals with OL-specific deletion of Itpr2 exhibit anxiety/depressive-like behaviors and manifest with interrupted OPC proliferation, leading to fewer mature OLs in the brain...
March 13, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38472610/when-will-the-glomerular-filtration-rate-in-former-preterm-neonates-catch-up-with-their-term-peers
#38
JOURNAL ARTICLE
Yunjiao Wu, Karel Allegaert, Robert B Flint, Sebastiaan C Goulooze, Pyry A J Välitalo, Matthijs de Hoog, Hussain Mulla, Catherine M T Sherwin, Sinno H P Simons, Elke H J Krekels, Catherijne A J Knibbe, Swantje Völler
AIMS: Whether and when glomerular filtration rate (GFR) in preterms catches up with term peers is unknown. This study aims to develop a GFR maturation model for (pre)term-born individuals from birth to 18 years of age. Secondarily, the function is applied to data of different renally excreted drugs. METHODS: We combined published inulin clearance values and serum creatinine (Scr) concentrations in (pre)term born individuals throughout childhood. Inulin clearance was assumed to be equal to GFR, and Scr to reflect creatinine synthesis rate/GFR...
March 12, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38469119/differentially-expressed-micrornas-targeting-genes-in-key-pathways-in-keratoconus
#39
JOURNAL ARTICLE
Dorota M Nowak-Malczewska, Joanna Swierkowska, Marzena Gajecka
Introduction: Keratoconus (KTCN) is a corneal ectasia, characterized by a progressive thinning and protrusion of the cornea, with a complex etiology involving genetic, behavioral, lifestyle, and environmental factors. Previous studies indicated that microRNAs (miRNAs) could be involved in KTCN pathogenesis. This in silico study aimed to identify precursor microRNAs (pre-miRNAs) differentially expressed in KTCN corneas and to characterize mature miRNAs and their target genes. Materials and methods: Expression levels of pre-miRNAs were retrieved from our previously obtained RNA sequencing data of 25 KTCN and 25 non-KTCN human corneas (PMID:28145428, PMID:30994860)...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38467996/effects-of-low-quality-forage-and-starter-protein-content-in-starter-diet-of-young-calves-on-growth-performance-rumen-fermentation-and-urinary-purine-derivatives
#40
JOURNAL ARTICLE
Reza Jalayerinejad, Mehdi Kazemi-Bonchenari, Mehdi Mirzaei, Mehdi HosseinYazdi
Feeding low-quality forage (LQF) has been evaluated in mature ruminants and results show that it has been improved nitrogen utilization efficiency. The present study evaluated the interaction effect of feeding wheat straw as LQF (0 and 7.5%, DM basis) and starter protein level (20 vs. 24%, DM basis) on growth performance, ruminal fermentation, and microbial protein synthesis in Holstein dairy calves raised under moderate heat stress condition. Forty-eight 3-day old dairy calves (averaging 40.6 kg) were assigned in four experimental treatments as follow; 1) no LQF with 20% CP (NLQF-20CP), 2) no LQF with 24% CP (NLQF-24CP), 3) 7...
March 12, 2024: Tropical Animal Health and Production
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