Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela Shih, Moshe Sade-Feldman, Genevieve M Boland, Karin Pelka, Martin J Aryee, Mari Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade. Critically, we discovered the stem-immunity hub, a subtype of immunity hub strongly associated with favorable PD-1-blockade outcome...
March 19, 2024: Nature Immunology