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https://www.readbyqxmd.com/read/29665629/evaluation-of-a-systematic-career-coaching-program-for-medical-students-in-korea-using-the-career-readiness-inventory
#1
Yera Hur, A Ra Cho, Eun Ji Song, Sun Kim
Purpose: The purpose of this study was to apply a systematic career coaching program to medical students and to evaluate its effectiveness. Methods: First year medical students from September to December in 2016 and 2017 of Konyang medical college experienced the FLEX Mentoring II: Career Coaching Program which had 16 sessions, 32hrs in total. The students took the 'career readiness inventory (CRI)' before the program and also after as a pre and post evaluation of the program...
April 18, 2018: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/29665612/differences-in-segmental-speeds-as-a-function-of-maturation-in-youth-baseball-pitchers
#2
Jessica K Washington, Gabrielle G Gilmer, Jeff W Barfield, Sarah S Gascon, Michael G Saper, Jeffrey R Dugas, James R Andrews, Gretchen D Oliver
The purpose of this study was to determine how stride length, segmental sequencing of the pelvis, trunk, humerus, and forearm velocities and accelerations, and the timing of these values change as youth mature. Thirteen youth baseball pitchers participated at three consecutive time points: visit 1 (10.7±1.3 years; 151.8±10.7 cm; 45.0±9.65 kg), visit 2 (11.5±1.6 years; 155.5±11.1 cm; 50.4±10.0 kg), and visit 3 (12.4±1.7 years; 161.5±11.7 cm; 56.4±10.8 kg). Participants executed three pitches for a strike to a catcher...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29663380/transglutaminase-activity-regulates-differentiation-migration-and-fusion-of-osteoclasts-via-affecting-actin-dynamics
#3
Huifang Sun, Mari T Kaartinen
Osteoclasts, bone resorbing cells, derive from monocyte/macrophage cell lineage. Increased osteoclast activity is responsible for bone destruction in diseases such as osteoporosis, periodontitis and rheumatoid arthritis. Transglutaminases (TGs), protein crosslinking enzymes, were recently found involved in osteoclastogenesis in vivo, however their mechanisms of action have remained unknown. In this study, we have investigated the role of TG activity in osteoclastogenesis in vitro using four TG inhibitors, NC9, Z006, T101, and monodansyl cadaverine...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29660375/the-secretome-of-adipose-derived-mesenchymal-stem-cells-protects-sh-sy5y-cells-from-arsenic-induced-toxicity-independent-of-a-neuron-like-differentiation-mechanism
#4
Theresa M Curtis, Joseph M Hannett, Rebecca M Harman, Nicholas A Puoplo, Gerlinde R Van de Walle
Arsenic exposure through contaminated food, water, and air causes irreversible neural damage and affects millions of people worldwide. Several studies have demonstrated that the secreted factors (secretome) from mesenchymal stromal/stem cells (MSCs) can promote neural recovery after several forms of injury including stroke and neurodegenerative diseases. The present study was conducted to determine if the secretome from adipose-derived MSCs (ADSCs) prevents arsenic damage to SH-SY5Y cells. To this end, human neuroblastoma cells (SH-SY5Y) were pre-treated with the secretome from ADSCs and then challenged with different concentrations of arsenic...
April 13, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29660326/characterization-of-16s-rrna-processing-with-pre-30s-subunit-assembly-intermediates-from-e-coli
#5
Brian A Smith, Neha Gupta, Kevin Denny, Gloria M Culver
Ribosomal RNA (rRNA) is a major component of ribosomes and is fundamental to the process of translation. In bacteria, 16S rRNA is a component of the small ribosomal subunit and plays a critical role in mRNA decoding. rRNA maturation entails the removal of intervening spacer sequences contained within the pre-rRNA transcript by nucleolytic enzymes. Enzymatic activities involved in maturation of the 5'-end of 16S rRNA have been identified, but those involved in 3'-end maturation of 16S rRNA are more enigmatic...
April 13, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29659607/phenotypic-plasticity-of-pre-adult-egg-maturation-in-a-parasitoid-effects-of-host-starvation-and-brood-size
#6
Yael Keinan, Rachel Braun, Tamar Keasar
Larvae of parasitoid wasps develop on a single arthropod host, and often face resource limitation that induces a tradeoff between egg maturation and somatic growth. Part of the variation in the growth-reproduction allocation was shown to be heritable, but how the larval developmental environment affects this allocation is not well-known. Detection of life history tradeoffs is often facilitated under stress conditions. We therefore exposed developing female larvae of the polyembryonic parasitoid Copidosoma koehleri (Hymenoptera: Encyrtidae) to laboratory manipulations aimed to restrict host resources (either host-starvation or high larval density)...
2018: PloS One
https://www.readbyqxmd.com/read/29659575/synergistic-co-regulation-and-competition-by-a-sox9-gli-foxa-phasic-transcriptional-network-coordinate-chondrocyte-differentiation-transitions
#7
Zhijia Tan, Ben Niu, Kwok Yeung Tsang, Ian G Melhado, Shinsuke Ohba, Xinjun He, Yongheng Huang, Cheng Wang, Andrew P McMahon, Ralf Jauch, Danny Chan, Michael Q Zhang, Kathryn S E Cheah
The growth plate mediates bone growth where SOX9 and GLI factors control chondrocyte proliferation, differentiation and entry into hypertrophy. FOXA factors regulate hypertrophic chondrocyte maturation. How these factors integrate into a Gene Regulatory Network (GRN) controlling these differentiation transitions is incompletely understood. We adopted a genome-wide whole tissue approach to establish a Growth Plate Differential Gene Expression Library (GP-DGEL) for fractionated proliferating, pre-hypertrophic, early and late hypertrophic chondrocytes, as an overarching resource for discovery of pathways and disease candidates...
April 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29658072/circular-rna-new-regulatory-molecules
#8
E A Belousova, M L Filipenko, N E Kushlinskii
Circular RNA are a family of covalently closed circular RNA molecules, formed from pre-mRNA of coding genes by means of splicing (canonical and alternative noncanonical splicing). Maturation of circular RNA is regulated by cis- and trans-elements. Complete list of biological functions of these RNA is not yet compiled; however, their capacity to interact with specific microRNA and play a role of a depot attracts the greatest interest. This property makes circular RNA active regulatory transcription factors. Circular RNA have many advantages over their linear analogs: synthesis of these molecules is conservative, they are universal, characterized by clearly determined specificity, and are resistant to exonucleases...
April 16, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29653286/stromal-cell-laden-3d-hydrogel-microwell-arrays-as-tumor-microenvironment-model-for-studying-stiffness-dependent-stromal-cell-cancer-interactions
#9
Xiaoshan Yue, Trung Dung Nguyen, Victoria Zellmer, Siyuan Zhang, Pinar Zorlutuna
Tumor properties such as growth and metastasis are dramatically dependent on the tumor microenvironment (TME). However, the diversity of the TME including the stiffness and the composition of the extracellular matrix (ECM), as well as the involvement of stromal cells, makes it extremely difficult to establish proper in vitro models for studying tumor growth and metastasis. In this research, we fabricated a stromal cell-laden microwell array system with tunable stiffness ranging from 200 Pa up to 3 kPa, which covers the stiffness range of normal and cancerous mammary tissues, to study the effect of ECM stiffness on stromal-cancer interaction...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29650156/temperature-variation-caused-by-sowing-dates-significantly-affects-floral-initiation-and-floral-bud-differentiation-processes-in-rapeseed-brassica-napus-l
#10
Tao Luo, Jing Zhang, Mohammad Nauman Khan, Jiahuan Liu, Zhenghua Xu, Liyong Hu
To understand the influence of temperature on floral initiation and to reveal the relationship between floral bud development and yield potential of rapeseed (Brassica napus L.), early- ("1358"), intermediate- ("Zhongshuang No.11") and late- ("Zheshuang No.8") maturity genotypes were sown on different sowing dates under field conditions during four crop seasons. A multiplicative model was introduced to distinguish and quantify the effects of photoperiod and temperature on pre-floral initiation phase...
June 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29649968/swimming-exercise-to-control-precocious-maturation-in-male-seabass-dicentrarchus-labrax
#11
Marco Graziano, Raul Benito, Josep V Planas, Arjan P Palstra
BACKGROUND: Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. In view of the known modulation of reproductive development by swimming exercise in other teleost species, we aimed at investigating the effects of sustained swimming on reproductive development in seabass males during the first year of life in order to determine if swimming could potentially reduce precocious sexual maturation...
April 12, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29627294/%C3%AE-arrestin-biased-agonism-of-%C3%AE-adrenergic-receptor-regulates-dicer-mediated-microrna-maturation-to-promote-cardioprotective-signaling
#12
Jian-Peng Teoh, Ahmed S Bayoumi, Tatsuya Aonuma, Yanyan Xu, John A Johnson, Huabo Su, Neal L Weintraub, Yaoliang Tang, Il-Man Kim
RATIONALE: MicroRNAs (miRs) are small, non-coding RNAs that function to post-transcriptionally regulate target genes. First transcribed as primary miR transcripts (pri-miRs), they are enzymatically processed by Drosha into premature miRs (pre-miRs) and further cleaved by Dicer into mature miRs. Initially discovered to desensitize β-adrenergic receptor (βAR) signaling, β-arrestins are now well-appreciated to modulate multiple pathways independent of G protein signaling, a concept known as biased signaling...
April 6, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29626165/collagen-xiii-is-required-for-neuromuscular-synapse-regeneration-and-functional-recovery-after-peripheral-nerve-injury
#13
Zarin Zainul, Anne Heikkinen, Hennariikka Koivisto, Iina Rautalahti, Mika Kallio, Shuo Lin, Heli Härönen, Oula Norman, Markus A Rüegg, Heikki Tanila, Taina Pihlajaniemi
Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein, and is able to regulate the formation and function of neuromuscular synapses. Its absence results in myasthenia, i.e. pre-and postsynaptic defects at the neuromuscular junction (NMJ), leading to destabilization of the motor nerves, muscle regeneration and atrophy. Mutations in COL13A1 have recently been found to cause congenital myasthenic syndrome (CMS), characterized by fatigue and chronic muscle weakness, which may be lethal...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29625123/expression-profiling-of-c-kit-and-its-impact-after-esirna-silencing-during-gonadal-development-in-catfish
#14
C Laldinsangi, B Senthilkumaran
C-kit receptor is a member of a family of growth factor receptors that have tyrosine kinase activity, and are involved in the transduction of growth regulatory signals across plasma membrane by activation of its ligand, kitl/scf. The present study analysed mRNA and protein expression profiles of c-kit in the gonads of catfish, Clarias gariepinus, using real time PCR, in situ hybridization and immunohistochemistry. Tissue distribution analysis revealed higher expression mainly in the catfish gonads. Ontogeny studies showed minimal expression during early developmental stages and highest during 50-75 days post hatch, and the dimorphic expression in gonads decreased gradually till adulthood, which might suggest an important role for this gene around later stages of sex differentiation and gonadal development...
April 3, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29623052/the-relationship-between-range-of-motion-and-injuries-in-adolescent-dancers-and-sportspersons-a-systematic-review
#15
Joyce M Storm, Roger Wolman, Eric W P Bakker, Matthew A Wyon
Background: The frequent and intensive training and performance of pre-professional ballet dancers and sportspersons is offered at a time when young ballet dancers and young athletes may be vulnerable to injury due to the progress through adolescence and growth spurts. Hypothesis: There are changes in range of motion during the progress through adolescence and growth periods in dancers and sportspersons. These changes in ROM can be linked to the increase of injury. Objectives: The primary aim of this systematic review is to determine whether there are changes in ROM during the progress through adolescence and growth spurts in dancers and sportspersons...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29619242/adolescents-and-health-related-behaviour-using-a-framework-to-develop-interventions-to-support-positive-behaviours
#16
Jan Pringle, Lawrence Doi, Divya Jindal-Snape, Ruth Jepson, John McAteer
Background: Experimentation is a natural part of adolescent maturation. In conjunction with increased exposure to behaviours such as alcohol or substance use, and the potentially intensified influence of peer groups, unhealthy behaviour patterns may develop as part of this experimentation. However, the adolescent years also provide considerable opportunity for behaviour to be shaped in positive ways that may improve immediate and longer term health outcomes. A systematic review carried out by the authors concluded that physiological changes during adolescence need to be considered when designing or implementing interventions, due to their influence on health behaviours...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29615326/characterization-of-centriole-duplication-in-human-epidermis-bowen-s-disease-and-squamous-cell-carcinoma
#17
Saori Watanuki, Harumi Fujita, Keisuke Kouyama, Masayuki Amagai, Akiharu Kubo
BACKGROUND: Centrosomes contain two centrioles: a pre-existing mature centriole and a newly formed immature centriole. Each centriole is duplicated once within a cell cycle, which is crucial for proper centrosome duplication and cell division. OBJECTIVE: To describe the centrosome duplication cycle in human epidermis, Bowen's disease (BD), and squamous cell carcinoma (SCC). METHODS: Immunofluorescent staining of centriolar proteins and Ki-67 was used to evaluate cell cycles and the number of centrioles...
March 16, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29614431/3d-cell-printing-of-in-vitro-stabilized-skin-model-and-in-vivo-pre-vascularized-skin-patch-using-tissue-specific-extracellular-matrix-bioink-a-step-towards-advanced-skin-tissue-engineering
#18
Byoung Soo Kim, Yang Woo Kwon, Jeong-Sik Kong, Gyu Tae Park, Ge Gao, Wonil Han, Moon-Bum Kim, Hyungseok Lee, Jae Ho Kim, Dong-Woo Cho
3D cell-printing technique has been under spotlight as an appealing biofabrication platform due to its ability to precisely pattern living cells in pre-defined spatial locations. In skin tissue engineering, a major remaining challenge is to seek for a suitable source of bioink capable of supporting and stimulating printed cells for tissue development. However, current bioinks for skin printing rely on homogeneous biomaterials, which has several shortcomings such as insufficient mechanical properties and recapitulation of microenvironment...
March 23, 2018: Biomaterials
https://www.readbyqxmd.com/read/29611771/the-effects-of-maturation-on-jumping-ability-and-sprint-adaptations-to-plyometric-training-in-youth-soccer-players
#19
Abbas Asadi, Rodrigo Ramirez-Campillo, Hamid Arazi, Eduardo Sáez de Villarreal
The aim of this study was to investigate the effects of maturation on power and sprint performance adaptations following 6 weeks of plyometric training in youth soccer players during pre-season. Sixty male soccer players were categorized into 3 maturity groups (Pre, Mid and Post peak height velocity [PHV]) and then randomly assigned to plyometric group and control group. Vertical jump, standing long jump, and 20-m sprint (with and without ball) tests were collected before- and after-intervention. After the intervention, the Pre, Mid and Post-PHV groups showed significant (P ≤ 0...
April 3, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29607336/the-effect-of-cardiac-arrhythmias-simulation-software-on-the-nurses-learning-and-professional-development
#20
Leila Bazrafkan, Mehdi Hemmati
Introduction: One of the important tasks of nurses in intensive care unit is interpretation of ECG. The use of training simulator is a new paradigm in the age of computers. This study was performed to evaluate the impact of cardiac arrhythmias simulator software on nurses' learning in the subspecialty Vali-Asr Hospital in 2016. Methods: This study was conducted by quasi-experimental randomized Salomon four group design with the participation of 120 nurses in subspecialty Vali-Asr Hospital in Tehran, Iran in 2016 that were selected purposefully and allocated in 4 groups...
April 2018: Journal of Advances in Medical Education & Professionalism
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