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https://www.readbyqxmd.com/read/29225888/contribution-to-diagnosis-and-treatment-of-bone-marrow-aspirate-results-in-critically-ill-patients-undergoing-bone-marrow-aspiration-a-retrospective-study-of-193-consecutive-patients
#1
Laure Calvet, Bruno Pereira, Anne-Françoise Sapin, Gabrielle Mareynat, Alexandre Lautrette, Bertrand Souweine
Background: The purpose of the work was to assess the contribution to diagnosis and/or treatment (CDT) of bone marrow aspiration (BMA) in the critically ill patient. Methods: The retrospective study included 193 patients. On the basis of BMA findings, contribution to diagnosis was defined by one of four previously unestablished diagnoses (maturation arrest of granulocyte precursors, hemophagocytic lymphohistiocytosis, hematological malignancy, marrow infiltration with cancer cells) and to treatment as the initiation or withdrawal of a specific treatment including the decision to forgo life-sustaining treatment (DFLST)...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29225350/maternal-by-environment-but-not-genotype-by-environment-interactions-in-a-fish-without-parental-care
#2
Regina Vega-Trejo, Megan L Head, Michael D Jennions, Loeske E B Kruuk
The impact of environmental conditions on the expression of genetic variance and on maternal effects variance remains an important question in evolutionary quantitative genetics. We investigate here the effects of early environment on variation in seven adult life history, morphological, and secondary sexual traits (including sperm characteristics) in a viviparous poeciliid fish, the mosquitofish Gambusia holbrooki. Specifically, we manipulated food availability during early development and then assessed additive genetic and maternal effects contributions to the overall phenotypic variance in adults...
December 11, 2017: Heredity
https://www.readbyqxmd.com/read/29225023/origins-and-specification-of-the-drosophila-wing
#3
David Requena, Jose Andres Álvarez, Hugo Gabilondo, Ryan Loker, Richard S Mann, Carlos Estella
The insect wing is a key evolutionary innovation that was essential for insect diversification. Yet despite its importance, there is still debate about its evolutionary origins. Two main hypotheses have been proposed: the paranotal hypothesis, which suggests that wings evolved as an extension of the dorsal thorax, and the gill-exite hypothesis, which proposes that wings were derived from a modification of a pre-existing branch at the dorsal base (subcoxa) of the leg. Here, we address this question by studying how wing fates are initially specified during Drosophila embryogenesis, by characterizing a cis-regulatory module (CRM) from the snail (sna) gene, sna-DP (for dorsal primordia)...
November 30, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29224263/-strategies-for-the-prevention-and-control-of-bleeding-due-to-vascular-injury-in-thoracoscopic-lung-surgery
#4
J D Mei, Q Pu, L Ma, C W Liu, L X Liu
The technique of thoracoscopic lung surgery has gradually matured. Nowadays, thoracoscope is recommended as the most preferred approach for surgical treatment of early stage non-small cell lung cancer in different guidelines. However, there are still some cases of accidential major bleeding due to vascular injury during thoracoscopic lung surgery. The wall of the hilum vessels is relatively thin. These vessels often involve a great portion of the cardiac output blood flow. Once the injury happened, the emergent condition may be life-threatening due to massive blood loss...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29223284/daily-rhythms-count-for-female-fertility
#5
REVIEW
Valérie Simonneaux, Thibault Bahougne, Eleni Angelopoulou
Female ovulation depends on a surge in circulating luteinizing hormone (LH) which occurs at the end of the resting period and requests high circulating estradiol. This fine tuning involves both an estradiol feedback as an indicator of oocyte maturation, and the master circadian clock of the suprachiasmatic nuclei as an indicator of the time of the day. This review describes the mechanisms through which daily time cues are conveyed to reproductive hypothalamic neurons to time the pre-ovulatory surge. In female rodents, neurotransmitters released by the suprachiasmatic nuclei activate the stimulatory kisspeptin neurons and reduce the inhibitory RFRP neurons precisely at the end of the afternoon of proestrus to allow a full surge in LH secretion...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29223146/investigation-of-mast-cell-toll-like-receptor-3-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-and-systemic-mastocytosis-participants-using-the-novel-application-of-automacs-magnetic-separation-and-flow-cytometry
#6
Cassandra Balinas, Thao Nguyen, Samantha Johnston, Peter Smith, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: Viral infections and hypersensitivities are commonly reported by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) patients. Mast Cells (MC) uniquely mediate type 1 hypersensitivities and resolve viral infections via toll-like receptor 3 (TLR3). OBJECTIVE: To characterise and compare mast cell progenitors (MCPs) in CFS/ME participants with a known MC disorder, Systemic mastocytosis (SM), and secondly, to investigate the role of MC TLR3 in CFS/ME participants following Polyinosinic:polycytidylic acid (Poly I:C) stimulation...
December 10, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29219187/integrated-molecular-biochemical-and-physiological-assessment-unravels-key-extraction-method-mediated-influences-on-rat-neonatal-cardiomyocytes
#7
Leonardo Jensen, Elida Neri, Vinicius Bassaneze, Nathalia Corrêa De Almeida Oliveira, Rafael Dariolli, Thiago Lauro Turaça, Débora Levy, Douglas Veronez, Mariana Sacrini Ayres Ferraz, Adriano Mesquita Alencar, Sérgio Paulo Bydlowski, Idágene Aparecida Cestari, José Eduardo Krieger
Neonatal cardiomyocytes are instrumental for disease modeling, but the effects of different cell extraction methods on basic cell biological processes remain poorly understood. We assessed the influence of two popular methods to extract rat neonatal cardiomyocytes, Pre-plating (PP) and Percoll (PC) on cell structure, metabolism, and function. Cardiomyocytes obtained from PP showed higher gene expression for troponins, titin, and potassium and sodium channels compared to PC. Also, PP cells displayed higher levels of troponin I protein...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29218439/characterization-and-expression-of-lin-28a-involved-in-lin28-let-7signal-pathway-during-early-development-of-p-olivaceus
#8
Yuanshuai Fu, Lina Gao, Zhiyi Shi, Feng You, Junling Zhang, Wenjuan Li
Heterochronic lin-28 is a conserved RNA-binding protein that plays a key role in the timing of developmental events in organisms. As a crucial heterochronic gene, the protein controls developmental events of the second of four larval stages in Caenorhabditi elegans. Heterochronic let-7 miRNAs are often present in various species and highly conserved in sequence and biological function and are required for various biological processes. Previous studies showed that ten let-7 miRNAs were identified in the Japanese flounder (Paralichthys olivaceus) and that they were primarily expressed during metamorphosis...
December 7, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29217690/re-positioning-of-somatic-golgi-apparatus-is-essential-for-the-dendritic-establishment-of-adult-born-hippocampal-neurons
#9
Sneha Rao, Gregory W Kirschen, Joanna Szczurkowska, Adrian Di Antonio, Jia Wang, Shaoyu Ge, Maya Shelly
New dentate granule cells are continuously generated, and integrate into the pre-existing hippocampal network in the adult brain. How an adult-born neuron with initially simple spindle-like morphology develops into a complex dentate granule cell (DGC), consisting of a single apical dendrite with further branches, remains largely unknown. Here, using retroviruses to birth-date and manipulate newborn neurons, we examined initial dendritic formation, and possible underlying mechanisms. We found that GFP-expressing newborn cells began to establish a DGC-like morphology at around 7 days after birth, with a primary dendrite pointing to the molecular layer, but at this stage, with several neurites in the neurogenic zone...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29216300/impacts-of-active-school-design-on-school-time-sedentary-behavior-and-physical-activity-a-pilot-natural-experiment
#10
Jeri Brittin, Leah Frerichs, John R Sirard, Nancy M Wells, Beth M Myers, Jeanette Garcia, Dina Sorensen, Matthew J Trowbridge, Terry Huang
BACKGROUND: Children spend a significant portion of their days in sedentary behavior (SB) and on average fail to engage in adequate physical activity (PA). The school built environment may influence SB and PA, but research is limited. This natural experiment evaluated whether an elementary school designed to promote movement impacted students' school-time SB and PA. METHODS: Accelerometers measured SB and PA at pre and post time-points in an intervention group who moved to the new school (n = 21) and in a comparison group experiencing no school environmental change (n = 20)...
2017: PloS One
https://www.readbyqxmd.com/read/29214820/weight-management-behaviors-among-mexican-american-youth-cross-sectional-variation-by-timing-of-growth-and-maturation
#11
Jennifer L Gay, Eva V Monsma, Katie Darby Hein
PURPOSE: To assess the association between growth and maturation with weight management behaviors (WMBs) among Mexican American youth. DESIGN: A cross-sectional design was used to measure timing of growth and maturation as well as WMBs. SAMPLE: Students were recruited through physical education classes in south Texas schools. The sample included 623 participants (52.3% female; 49.8% with weight ≥85th percentile) in grades 4 through 12. Students in middle school were purposely oversampled to examine questions around timing of growth and maturation...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29213229/reflex-modification-audiometry-reveals-dual-roles-for-olivocochlear-neurotransmission
#12
Paul D Allen, Anne E Luebke
Approximately 15% of American adults report some degree of difficulty hearing in a noisy environment or have auditory filtering difficulties. There are objective clinical tests of auditory filtering, yet few tests exist for mouse models that do not rely on extensive training. We have used reflex modification audiometry (RMA) and developed exclusion criteria for the mouse model. This RMA based test makes use of the acoustic startle response (ASR) and the ability of prepulses to inhibit the ASR [i.e., prepulse inhibition (PPI)] to assess the mouse's ability to detect prepulse signals presented in quiet or embedded in masking noise...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29212662/sharing-the-load-mex67-mtr2-cofunctions-with-los1-in-primary-trna-nuclear-export
#13
Kunal Chatterjee, Shubhra Majumder, Yao Wan, Vijay Shah, Jingyan Wu, Hsiao-Yun Huang, Anita K Hopper
Eukaryotic transfer RNAs (tRNAs) are exported from the nucleus, their site of synthesis, to the cytoplasm, their site of function for protein synthesis. The evolutionarily conserved β-importin family member Los1 (Exportin-t) has been the only exporter known to execute nuclear export of newly transcribed intron-containing pre-tRNAs. Interestingly, LOS1 is unessential in all tested organisms. As tRNA nuclear export is essential, we previously interrogated the budding yeast proteome to identify candidates that function in tRNA nuclear export...
December 6, 2017: Genes & Development
https://www.readbyqxmd.com/read/29209617/mirroring-the-multiple-potentials-of-micrornas-in-acute-myocardial-infarction
#14
REVIEW
Solenne Paiva, Onnik Agbulut
At present, cardiovascular diseases are depicted to be the leading cause of death worldwide according to the World Health Organization. In the future, projections predict that ischemic heart disease will persist in the top main causes of illness. Within this alarming context, some tiny master regulators of gene expression programs, namely, microRNAs (miRNAs) carry three promising potentials. In fact, miRNAs can prove to be useful not only in terms of biomarkers allowing heart injury detection but also in terms of therapeutics to overcome limitations of past strategies and treat the lesions...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29206332/inactivation-of-mtorc1-signaling-in-osterix-expressing-cells-impairs-b-cell-differentiation
#15
Yongkui Wang, Min Xiao, Chen Tao, Jing Chen, Zhenyu Wang, Jun Yang, Zhenguo Chen, Zhipeng Zou, Anling Liu, Daozhang Cai, Yu Jiang, Changhai Ding, Mangmang Li, Xiaochun Bai
Osteoblasts provide a microenvironmental niche for B-cell commitment and maturation in the bone marrow (BM). Any abnormity of osteoblasts function may result in the defect of B lymphopoiesis. Signaling from mechanistic target of rapamycin complex 1 (mTORC1) has been implicated in regulating the expansion and differentiation of osteoblasts. Thus, we raise a hypothesis that mTORC1 signaling in osteoblasts plays a vital role in B-cell development. Inactivation of mTORC1 in osterix-expressing cells (mainly osteoblast lineage) through Osx-Cre-directed deletion of Raptor (an mTORC1-specific component) resulted in a reduction in the total B-cell population in the BM, which was due to a block in early B-cell development from the pro-B to pre-B cell stage...
December 5, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29205453/localization-of-thrombospondin-1-and-its-receptor-cd36-in-the-ovary-of-the-ostrich-struthio-camelus
#16
D Rodler, F Sinowatz
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a decisive role for the rapid growth of avian follicles. Compared to mammals, few data on the angiogenesis in the avian ovary are available. However, whereas several pro-angiogenic factors in the avian ovary have been recently studied in detail, little information is available on the localization of anti-angiogenic factors. The aim of this study was to determine the localization and possible function of the anti-angiogenic factor thrombospondin-1 (TSP-1) and its receptor CD36 in the ovary of the ostrich using immunohistochemistry and to correlate the results with ultrastructural data...
December 4, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29201072/the-role-of-kisspeptin-in-female-reproduction
#17
REVIEW
Sareh Zeydabadi Nejad, Fahimeh Ramezani Tehrani, Azita Zadeh-Vakili
Context: Kisspeptin (KISS1), a recently discovered neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons, is critical for maturation and function of the reproductive axis. This review aimed at providing comprehensive and up-to-date information on Kisspeptin and its role in female reproduction. Evidence Acquisition: A literature review was performed using PubMed for all English language articles published between 1999 and 2016. Results: The kisspeptin system (KISS1/G protein-coupled receptor-54,GPR54) has recently been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29194185/does-maturity-status-affect-the-relationship-between-anaerobic-speed-reserve-and-multiple-sprints-sets-performance-in-young-soccer-players
#18
Mohamed Amin Selmi, Badriya Al-Haddabi, Mohamed Haj Yahmed, Radhouane Haj Sassi
The purpose of this study is to examine the relationship between repeated-sprint sets (RSS) performance indices and anaerobic speed reserve (ASR) in young soccer players of different maturity status. One hundred and seventy nine young male soccer players (11.1 to 17.8 years) classified as pre- (n=50), circum- (n=60), or post- (n=69) peak height velocity (PHV) performed multi-stage shuttle run test (MRST) to measure maximal aerobic speed (MAS), 30-m sprint with 10-m splits to estimate maximal anaerobic speed (MAnS), and RSS test...
November 29, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29193878/development-of-a-transendothelial-shuttle-by-macrophage-modification
#19
Johan Georg Visser, Carine Smith
One of the limiting factors in tissue regeneration, particularly in the context of chronic disease such as myodystrophy, motor neuron disease, sarcopenia and cardiovascular disease, is limited availability of stem cells. We propose employing autologous macrophages to deliver stem cells, thereby facilitating tissue regeneration, by a novel and relatively non-invasive therapeutic intervention. Circulatory monocytic cells of M1 phenotype have capacity for transendothelial migration to infiltrate damaged tissue, making them ideal delivery vehicles...
November 29, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29193660/preterm-birth-with-placental-evidence-of-malperfusion-is-associated-with-cardiovascular-risk-factors-after-pregnancy-a-prospective-cohort-study
#20
Janet M Catov, Matthew F Muldoon, Steven E Reis, Roberta B Ness, Lananh N Nguyen, Jose-Miguel Yamal, Hyunsoo Hwang, W Tony Parks
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. DESIGN: Pregnancy cohort study. SETTING: Pittsburgh Pennsylvania, US. POPULATION: Women with PTB (n=115) and term births (n=210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers were compared in women with prior PTB vs...
November 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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