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Cerebrovascular Malformations

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https://www.readbyqxmd.com/read/27907955/decompressive-craniectomy-in-neurocritical-care
#1
Erik G Hayman, David B Kurland, Zachary Grunwald, Sebastian Urday, Kevin N Sheth, J Marc Simard
Neurosurgeons increasingly use decompressive craniectomy (DC) in neurocritical care. In this review, the authors summarize the topic of DC for the neurointensivist. Following a brief overview of the procedure, the major indications for the procedure are described. This includes a review of the literature regarding well-established indications, such as infarction and traumatic brain injury, as well as lesser known indications, including intracerebral hemorrhage, ruptured cerebrovascular malformations, sinus thrombosis, and infection...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27881343/-surgical-management-of-proximal-anterior-cerebral-artery-a1-aneurysms
#2
Hua-Wei Wang, Zhe Xue, Yu-Dong Ma, Wen-Xin Wang, Chen Wu, Zheng-Hui Sun
OBJECTIVE: To review our experience in surgical management of proximal anterior cerebral artery (A1) aneurysms in 23 patients. METHODS: Between January, 2004 and December, 2014, 23 patients (1.6%) with A1 aneurysms diagnosed by CTA or DSA were treated surgically. The "3H" therapy was adopted for postoperative prevention of cerebrovascular spasm. All the patients were followed up and examined with cerebrovascular CTA at 6, 12, 48 and 60 months after the operation with their Glasgow Outcome Scale score recorded...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27873347/infantile-hemangioma-with-minimal-or-arrested-growth-further-observations-on-clinical-and-histopathologic-findings-of-this-unique-but-underrecognized-entity
#3
Ellen Hui Ma, Susan J Robertson, Chung W Chow, Philip S Bekhor
BACKGROUND: Infantile hemangioma (IH) with minimal or arrested growth (IH-MAG) is becoming increasingly recognized in the literature. It is important to be aware of their existence, because the correct diagnosis is essential for prognostication and treatment and, in the case of facial segmental lesions, the direction of further investigations if PHACE (posterior fossa abnormalities and other structural brain abnormalities; hemangioma(s) of the cervical facial region; arterial cerebrovascular anomalies; cardiac defects, aortic coarctation, and other aortic abnormalities; eye anomalies) syndrome or Sturge-Weber syndrome is suspected...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27816803/lumen-segmentation-in-magnetic-resonance-images-of-the-carotid-artery
#4
Danilo Samuel Jodas, Aledir Silveira Pereira, João Manuel R S Tavares
Investigation of the carotid artery plays an important role in the diagnosis of cerebrovascular events. Segmentation of the lumen and vessel wall in Magnetic Resonance (MR) images is the first step towards evaluating any possible cardiovascular diseases like atherosclerosis. However, the automatic segmentation of the lumen is still a challenge due to the low quality of the images and the presence of other elements such as stenosis and malformations that compromise the accuracy of the results. In this article, a method to identify the location of the lumen without user interaction is presented...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27816341/stroke-prevention
#5
Clothilde Isabel, David Calvet, Jean-Louis Mas
Patients who have had a stroke are at high risk for recurrent stroke, myocardial infarction, and vascular death. Prevention of these events should be initiated promptly after stroke, because many recurrent events occur early, and should be tailored to the precise cause of stroke, which may require specific treatment. Lifestyle advice including abstinence from smoking, regular exercise, Mediterranean-style diet, and reduction of salt intake and alcohol consumption are recommended for all patients with stroke...
November 3, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27797413/selective-arterial-spin-labeling-in-conjunction-with-phase-contrast-acquisition-for-the-simultaneous-visualization-of-morphology-flow-direction-and-velocity-of-individual-arteries-in-the-cerebrovascular-system
#6
Thomas Lindner, Naomi Larsen, Olav Jansen, Michael Helle
PURPOSE: In various cerebrovascular diseases the visualization of individual arteries and knowledge about their hemodynamic properties, like flow velocity and direction, can become important for an accurate diagnosis. Magnetic resonance angiography methods are intended to acquire this information, but often a single acquisition is not sufficient to retrieve all of this desired information. METHODS: Using selective arterial spin labeling (ASL) methods, a single artery of interest can be tagged and visualized, whereas quantitative information about hemodynamics can be retrieved using phase-contrast techniques that are often limited regarding their selectivity...
October 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27755938/arterial-spin-labeling-perfusion-of-the-brain-emerging-clinical-applications
#7
Sven Haller, Greg Zaharchuk, David L Thomas, Karl-Olof Lovblad, Frederik Barkhof, Xavier Golay
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. In this article, the main labeling techniques, notably pulsed and pseudocontinuous ASL, as well as emerging clinical applications will be reviewed. In dementia, the pattern of hypoperfusion on ASL images closely matches the established patterns of hypometabolism on fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images due to the close coupling of perfusion and metabolism in the brain...
November 2016: Radiology
https://www.readbyqxmd.com/read/27739942/improved-outcomes-for-patients-with-cerebrovascular-malformations-at-high-volume-centers-the-impact-of-surgeon-and-hospital-volume-in-the-united-states-2000-2009
#8
Jason M Davies, Michael T Lawton
OBJECTIVE Treatment of cerebrovascular malformations has grown in complexity with the development of multimodal approaches, including microsurgery, endovascular treatments, and radiosurgery. In spite of this changing standard of care, the provision of care continues across a variety of settings. The authors sought to determine the risk of adverse outcome after treatment of patients with vascular malformations in the US. Patient, surgeon, and hospital characteristics, including volume, were tested as potential outcome predictors...
October 14, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27698825/glioma-coexisting-with-angiographically-occult-cerebrovascular-malformation-a-case-report
#9
Junhui Chen, Lei Chen, Chunlei Zhang, Jianqing He, Peipei Li, Jingxu Zhou, Jun Zhu, Yuhai Wang
Angiographically occult cerebrovascular malformation (AOVM) is a type of complex cerebrovascular malformation that is not visible on digital subtraction angiography (DSA). Vascular malformation coexisting with glioma is clinically rare, and glioma coexisting with AOVM is even more rare. To the best of our knowledge, the present study is the first to report glioma coexisting with AOVM in the literature. The present study reports a rare case of glioma coexisting with AOVM in a 30-year-old male patient. Computed tomography (CT) scan revealed calcification, hemorrhage and edema in the right frontal lobe...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27637962/cerebrovascular-disease
#10
M L P Portegies, P J Koudstaal, M A Ikram
With 16.9 million people who suffered a first-ever stroke in 2010 worldwide, stroke is a very common vascular disease. Epidemiologic studies have played an essential role in assessing this burden and in detecting the risk factors for stroke. Primary prevention of these risk factors, primarily hypertension, smoking, diabetes, and atrial fibrillation, has reduced the incidence in high-income countries. However, stroke remains a major cause of death and disability, and therefore research should be continued. Subarachnoid hemorrhages are less prevalent than strokes but have an even higher risk of death...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27599908/evaluation-of-qualitative-outcomes-after-surgical-intervention-on-patients-affected-by-arteriovenous-malformations
#11
Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Antonina Sidoti, Placido Bramanti, Silvia Marino
BACKGROUND: Arteriovenous malformations are abnormal tangles of blood vessels that cause irregular connections between arteries and veins. Rupture of arteriovenous malformations represents a frequent complication associated with a neurological impairment and physical disability. METHODS: We investigated the relationship among coping dimensions and overall quality of life (QoL), and health status after surgical intervention in 20 patients affected by arteriovenous malformations...
September 2, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27554072/development-of-abnormal-hemispheric-vascular-networks-mimicking-cerebral-proliferative-angiopathy-in-a-child-originally-diagnosed-with-deep-seated-arteriovenous-fistula
#12
Hiroyuki Sakata, Miki Fujimura, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Teiji Tominaga
Cerebral proliferative angiopathy (CPA), which is characterized by diffuse vascular abnormalities with intermingled normal brain parenchyma, is a rare clinical entity distinct from classical cerebral arteriovenous malformations. Its pathology at initial state and subsequent course of progression has totally been undetermined. We herein presented a case of a child who was initially diagnosed with deep-seated arteriovenous fistula (AVF), and ultimately developed symptomatic CPA-like vascular lesion over a long period of clinical follow-up...
October 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27513872/micro-ct-imaging-reveals-mekk3-heterozygosity-prevents-cerebral-cavernous-malformations-in-ccm2-deficient-mice
#13
Jaesung P Choi, Matthew Foley, Zinan Zhou, Weng-Yew Wong, Naveena Gokoolparsadh, J Simon C Arthur, Dean Y Li, Xiangjian Zheng
Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals. These mouse models provide invaluable tools to investigate molecular mechanism and therapeutic approaches for CCM disease. However, the full value of these animal models is limited by the lack of an accurate and quantitative method to assess lesion burden and progression. In the present study we have established a refined and detailed contrast enhanced X-ray micro-CT method to measure CCM lesion burden in mouse brains...
2016: PloS One
https://www.readbyqxmd.com/read/27494548/operative-volume-and-outcomes-of-cerebrovascular-neurosurgery-in-children
#14
Kimon Bekelis, Ian D Connolly, Huy M Do, Omar Choudhri
OBJECTIVE The impact of procedural volume on the outcomes of cerebrovascular surgery in children has not been determined. In this study, the authors investigated the association of operative volume on the outcomes of cerebrovascular neurosurgery in pediatric patients. METHODS The authors performed a cohort study of all pediatric patients who underwent a cerebrovascular procedure between 2003 and 2012 and were registered in the Kids' Inpatient Database (KID). To control for confounding, the authors used multivariable regression models, propensity-score conditioning, and mixed-effects analysis to account for clustering at the hospital level...
August 5, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27492240/derivation-of-self-inhibitory-helical-peptides-to-target-rho-kinase-dimerization-in-cerebrovascular-malformation-structural-bioinformatics-analysis-and-peptide-binding-assay
#15
Xuyang Wang, Dianqi Hou, Weiwei Dai, Wenwei Gao, Shiming Ju, Heli Cao, Lin Zhang, Gan Wang, Yan Guo, Shiwen Chen, Hengli Tian, Zhiqiang Li
Rho-kinase dimerization is essential for its kinase activity and biological function; disruption of the dimerization has recently been established as a new and promising therapeutics strategy for cerebrovascular malformation (CM). Based on Rho-kinase dimer crystal structure we herein combined in silico analysis and in vitro assay to rationally derive self-inhibitory peptides from the dimerization interface. Three peptides namely Hlp1, Hlp2 and Hlp3 were successfully designed that have potential capability to rebind at the dimerization domain of Rho-kinase...
July 2016: Molecular Informatics
https://www.readbyqxmd.com/read/27426100/endovascular-and-surgical-approaches-of-ethmoidal-dural-fistulas-a-multicenter-experience-and-a-literature-review
#16
D Cannizzaro, S Peschillo, M Cenzato, G Pero, M C Resta, G Guidetti, N Burdi, M Piccirilli, A Santoro, G Lanzino
Ethmoidal dural arteriovenous fistulae are rare vascular malformations associated with a high risk of bleeding. We present a multicenter contemporary series of patients treated with microsurgical and endovascular techniques. Sixteen consecutive patients were evaluated and/or treated between 2008 and 2015 at four centers with large experience in the endovascular and surgical treatment of cerebrovascular diseases. We analyzed demographic and clinical data, risk factors for dural fistulas, treatment type, peri- and post-operative morbidity, clinical and radiological outcomes, rates of occlusion, and long-term neurological outcome...
July 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27423615/cerebral-cavernous-malformations-with-diffuse-manifestation-a-benign-entity
#17
Satoshi Tsutsumi, Ikuko Ogino, Masakazu Miyajima, Hajime Arai, Masanori Ito, Yukimasa Yasumoto
PURPOSE: Cerebral cavernous malformations (CCMs) are a distinct cerebrovascular disease. A fraction of CCMs present as diffuse manifestations distributed over the cerebral hemispheres, cerebellum, and brainstem. The purpose of the present study was to explore the clinical picture of such CCMs. METHODS: This study assessed the appearance of CCMs on magnetic resonance (MR) images, the presence of genetic mutations using the polymerase chain reaction method, and disease course over long-term follow-up in a total of 10 patients with diffuse CCMs...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27388469/incidence-and-possible-causes-of-nontraumatic-convexal-subarachnoid-haemorrhage-in-chinese-patients-a-retrospective-review
#18
Haiyan Zhao, Jintao Han, Ming Lu, Yingshuang Zhang, Dongsheng Fan
OBJECTIVE: To explore the incidence and possible underlying pathogenic mechanisms of nontraumatic convexal subarachnoid haemorrhage (cSAH; a rarely reported condition) in a cohort of Chinese patients. METHODS: Medical records from all patients with subarachnoid haemorrhage (SAH) who had been treated at Peking University Third Hospital, China, between January 2010 and December 2014 were retrospectively reviewed to identify cases of cSAH. RESULTS: Of 144 patients with SAH, cSAH was observed in 14 cases (9...
July 7, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27366977/landmark-papers-in-cerebrovascular-neurosurgery-2015
#19
REVIEW
Justin M Moore, Christoph J Griessenauer, Raghav Gupta, Nimer Adeeb, Apar S Patel, Christopher S Ogilvy, Ajith J Thomas
The management of cerebrovascular disease has advanced considerably in 2015. Five randomized control trials have firmly established the role of endovascular thrombectomy for ischemic strokes due to large vessel occlusion. The randomized trial of intraarterial treatment for acute ischemic stroke (MR CLEAN) (Berkhemer et al. NEJM 2015;372:11-20) was the first of a series on the topic. There was a total of 5 randomized controlled trials published showing benefit in terms of functional outcomes at 90days for mechanical thrombectomy including the Endovascular Therapy for Ischemic stroke with perfusion-imaging selection (EXTEND IA) (Campbell et al...
September 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27327518/endoscopic-endonasal-skull-base-surgery-for-vascular-lesions-a-systematic-review-of-the-literature
#20
Francisco Vaz-Guimaraes, Paul A GARDNERl, Juan C Fernandez-Miranda, Eric Wang, Carl H Snyderman
INTRODUCTION: Endoscopic endonasal skull base surgery for vascular lesions is a controversial topic in neurosurgical practice. Concerns regarding the ability to effectively work through the relatively narrow and deep endonasal corridor and manage serious hemorrhagic complications such as inadvertent internal carotid artery (ICA) injury during endoscopic surgery (EES) are relevant sources of disagreement between neurosurgeons. Nevertheless, following careful preoperative evaluation, EES may be indicated for rare, well-selected cases, including medially-projecting paraclinoid aneurysms and cavernous malformations (CMs) located next to the ventral surface of the brainstem...
December 2016: Journal of Neurosurgical Sciences
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