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Jonathan Buscaglia

Firas Al-Kawas, Harry Aslanian, John Baillie, Filip Banovac, Jonathan M Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A Coté, Peter V Draganov, Kulwinder Dua, Valerie Durkalski, B Joseph Elmunzer, Lydia D Foster, Timothy B Gardner, Brian S Geller, Priya Jamidar, Laith H Jamil, Rajesh N Keswani, Mouen A Khashab, Gabriel D Lang, Ryan Law, David Lichtenstein, Simon K Lo, Sean McCarthy, Silvio Melo, Daniel Mullady, Jose Nieto, J Bayne Selby, Vikesh K Singh, Rebecca L Spitzer, Brian Strife, Paul Tarnaksy, Jason R Taylor, Jeffrey Tokar, Andrew Y Wang, April Williams, Field Willingham, Patrick Yachimski
BACKGROUND: The optimal approach to the drainage of malignant obstruction at the liver hilum remains uncertain. We aim to compare percutaneous transhepatic biliary drainage (PTBD) to endoscopic retrograde cholangiography (ERC) as the first intervention in patients with cholestasis due to suspected malignant hilar obstruction (MHO). METHODS: The INTERCPT trial is a multi-center, comparative effectiveness, randomized, superiority trial of PTBD vs. ERC for decompression of suspected MHO...
February 14, 2018: Trials
Michael Mintz, Shanawaj Khair, Suman Grewal, Joseph F LaComb, Jiyhe Park, Breana Channer, Ramona Rajapakse, Juan Carlos Bucobo, Jonathan M Buscaglia, Farah Monzur, Anupama Chawla, Jie Yang, Charlie E Robertson, Daniel N Frank, Ellen Li
BACKGROUND: Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitoring microbial composition in the recipient before and after FMT, as compared with their respective donor...
2018: PloS One
Herve Tiriac, Juan Carlos Bucobo, Demetrios Tzimas, Suman Grewel, Joseph F Lacomb, Leahana M Rowehl, Satish Nagula, Maoxin Wu, Joseph Kim, Aaron Sasson, Shivakumar Vignesh, Laura Martello, Maria Munoz-Sagastibelza, Jonathan Somma, David A Tuveson, Ellen Li, Jonathan M Buscaglia
BACKGROUND AND AIMS: Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately the vast majority of patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) in patients with PDA...
January 8, 2018: Gastrointestinal Endoscopy
Spyridon Pagkratis, Sara Kryeziu, Miranda Lin, Samah Hoque, Juan Carlos Bucobo, Jonathan M Buscaglia, Georgios V Georgakis, Aaron R Sasson, Joseph Kim
RATIONALE: Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly complex. This case report demonstrates successful pancreatic cancer resection despite the patient's complicated anatomy. PATIENT CONCERNS: An 82-year-old female presented to our institution with complaints of mild right upper quadrant pain radiating to the mid-epigastric region...
December 2017: Medicine (Baltimore)
Galen Leung, Jela Bandovic, Jonathan M Buscaglia
No abstract text is available yet for this article.
December 2, 2017: Clinical Gastroenterology and Hepatology
Dennis Yang, Jonathan M Buscaglia
No abstract text is available yet for this article.
December 2, 2017: Clinical Gastroenterology and Hepatology
Jae-Seok Roe, Chang-Il Hwang, Tim D D Somerville, Joseph P Milazzo, Eun Jung Lee, Brandon Da Silva, Laura Maiorino, Hervé Tiriac, C Megan Young, Koji Miyabayashi, Dea Filippini, Brianna Creighton, Richard A Burkhart, Jonathan M Buscaglia, Edward J Kim, Jean L Grem, Audrey J Lazenby, James A Grunkemeyer, Michael A Hollingsworth, Paul M Grandgenett, Mikala Egeblad, Youngkyu Park, David A Tuveson, Christopher R Vakoc
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model. This approach revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity. We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanism that renders PDA cells more invasive and less anchorage-dependent for growth in vitro, as well as more metastatic in vivo...
August 24, 2017: Cell
Satish Nagula, Kamron Pourmand, Harry Aslanian, Juan Carlos Bucobo, Tamas A Gonda, Susana Gonzalez, Adam Goodman, Seth A Gross, Sammy Ho, Christopher J DiMaio, Michelle K Kim, Shireen Pais, John M Poneros, David H Robbins, Felice Schnoll-Sussman, Amrita Sethi, Jonathan M Buscaglia
BACKGROUND & AIMS: Endoscopic ultrasound with fine-needle aspiration (FNA) is the standard of care for tissue sampling of solid lesions adjacent to the gastrointestinal tract. Fine-needle biopsy (FNB) may provide higher diagnostic yield with fewer needle passes. The aim of this study was to assess the difference in diagnostic yield between FNA and FNB. METHODS: This is a multicenter, prospective randomized clinical trial from 6 large tertiary care centers. Patients referred for tissue sampling of solid lesions were randomized to either FNA or FNB of the target lesion...
June 15, 2017: Clinical Gastroenterology and Hepatology
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Steven A Edmundowicz, John M DeWitt, Mouen A Khashab, Andrew Y Wang, Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo, Mihir S Wagh, Peter V Draganov, Tyler Stevens, John J Vargo, Harshit S Khara, David L Diehl, Rajesh N Keswani, Srinadh Komanduri, Patrick S Yachimski, Anoop Prabhu, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Petros Benias, David L Carr-Locke, Christopher J DiMaio
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States...
February 2017: Endoscopy International Open
Jonathan M Buscaglia
No abstract text is available yet for this article.
February 1, 2017: Clinical Gastroenterology and Hepatology
Dennis Yang, Jose M Nieto, Ali Siddiqui, Brian P Riff, Christopher J DiMaio, Satish Nagula, Amr M Ismail, Saowanee Ngamreungphong, Mouen A Khashab, Mihir S Wagh, Demetrios Tzimas, Jonathan M Buscaglia, Daniel S Strand, Andrew Y Wang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
Background and study aim Use of the fully covered self-expandable metal stent (SEMS) for benign luminal gastrointestinal (GI) stricture (BLGS) has been limited by the migration rate. The role of the lumen-apposing metal stent (LAMS) for BLGS is not well defined. We assessed the safety, feasibility, and efficacy of LAMS for the treatment of BLGS. Patients and methods This was an observational, open-label, retrospective, single-arm, multicenter consecutive case series of patients undergoing LAMS placement for BLGS...
April 2017: Endoscopy
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
January 6, 2017: Gastrointestinal Endoscopy
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
February 2017: Gastrointestinal Endoscopy
Vivek Kumbhari, Irene Peñas, Alan H Tieu, Carlos De la Serna-Higuera, Manie Juneja, Fuad Maufa, Saowanee Ngamruengphong, Mohamad H El-Zein, Nadim Haddad, Sandeep Krishnan, Susana Gonzalez, Peter V Renny, Payal Saxena, Linda Howard, Christopher J DiMaio, Jonathan M Buscaglia, Manuel Perez-Miranda, Mouen A Khashab
BACKGROUND AND AIMS: To facilitate access for interventional EUS, flexible (nitinol) 19-G needles have been introduced to permit needle puncture even when the echoendoscope is in an angulated position, such as in the second part of the duodenum. The aims of the study were to evaluate the performance of a flexible 19-G needle during interventional EUS procedures and compare outcomes when the echoendoscope was in the straight versus angulated position. METHODS: A retrospective review was undertaken of 162 consecutive patients that underwent a variety of interventional EUS procedures with a flexible 19-G needle across five centers...
December 2016: Digestive Diseases and Sciences
Jonathan M Buscaglia
No abstract text is available yet for this article.
October 2016: Clinical Gastroenterology and Hepatology
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Youngkyu Park, Keith Rivera, Wilhelm Palm, John Wilson, Vineet Sangar, Yuan Hao, Daniel Öhlund, Kevin Wright, Dea Filippini, Eun Jung Lee, Brandon Da Silva, Christina Schoepfer, John Erby Wilkinson, Jonathan M Buscaglia, Gina M DeNicola, Herve Tiriac, Molly Hammell, Howard C Crawford, Edward E Schmidt, Craig B Thompson, Darryl J Pappin, Nahum Sonenberg, David A Tuveson
Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells...
August 11, 2016: Cell
Mohammad F Madhoun, Gregory A Cote, Sushil K Ahlawat, Nuzhat A Ahmad, Jonathan M Buscaglia, Audrey H Calderwood, Seth Crockett, Dayna S Early, Ferga C Gleeson, Suryakanth R Gurudu, Thomas F Imperiale, Julia J Liu, Patrick Mosler, Rahul Pannala, Patrick R Pfau, Joseph Romagnuolo, Jewel Samadder, Amrita Sethi, Amandeep K Shergill, Eun J Shin, Field Willingham, Jason A Dominitz
BACKGROUND AND AIMS: Since 1985, the American Society for Gastrointestinal Endoscopy (ASGE) has awarded grants for endoscopic-related research. The goals of this study were to examine trends in ASGE grant funding and to assess productivity of previous recipients of the ASGE grant awards. METHODS: This was a retrospective cohort analysis of all research grants awarded by the ASGE through 2009. Measures of academic productivity and self-assessment of the ASGE awards' impact on the recipients' careers were defined by using publicly available resources (eg, National Library of Medicine-PubMed) and administration of an electronic survey to award recipients...
September 2016: Gastrointestinal Endoscopy
Yingjie Yu, Qi Zhang, Jonathan Buscaglia, Chung-Chueh Chang, Ying Liu, Zhenhua Yang, Yichen Guo, Yantian Wang, Kalle Levon, Miriam Rafailovich
In this study, a sensitive, yet robust, biosensing system with real-time electrochemical readout was developed. The biosensor system was applied to the detection of carcinoembryonic antigen (CEA), which is a common marker for many cancers such as pancreatic, breast, and colon cancer. Real time detection of CEA during a medical procedure can be used to make critical decisions regarding further surgical intervention. CEA was templated on gold surface (RMS roughness ∼3-4 nm) coated with a hydrophilic self-assembled monolayer (SAM) on the working electrode of an open circuit potentiometric network...
July 21, 2016: Analyst
C Lascarides, J M Buscaglia, P I Denoya, S Nagula, J C Bucobo, R Bergamaschi
AIM: A randomized controlled trial (RCT) was conducted to test the null hypothesis that there is no difference in complication rates and length of stay (LOS) between laparoscopic right colectomy (LRC) and laparoscopic-assisted colonoscopic polypectomy (LACP) for endoscopically unresectable polyps of the right colon. METHOD: A single-centre RCT (NCT01986699) was conducted on patients with polyps of the right colon deemed by the gastroenterologist to be unresectable...
November 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Mohamed O Othman, Jonathan M Buscaglia
No abstract text is available yet for this article.
April 2016: Clinical Gastroenterology and Hepatology
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