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Jonathan Buscaglia

Vivek Kumbhari, Irene Peñas, Alan H Tieu, Carlos De la Serna-Higuera, Manie Juneja, Fuad Maufa, Saowanee Ngamruengphong, Mohamad H El-Zein, Nadim Haddad, Sandeep Krishnan, Susana Gonzalez, Peter V Renny, Payal Saxena, Linda Howard, Christopher J DiMaio, Jonathan M Buscaglia, Manuel Perez-Miranda, Mouen A Khashab
BACKGROUND AND AIMS: To facilitate access for interventional EUS, flexible (nitinol) 19-G needles have been introduced to permit needle puncture even when the echoendoscope is in an angulated position, such as in the second part of the duodenum. The aims of the study were to evaluate the performance of a flexible 19-G needle during interventional EUS procedures and compare outcomes when the echoendoscope was in the straight versus angulated position. METHODS: A retrospective review was undertaken of 162 consecutive patients that underwent a variety of interventional EUS procedures with a flexible 19-G needle across five centers...
October 6, 2016: Digestive Diseases and Sciences
Jonathan M Buscaglia
No abstract text is available yet for this article.
October 2016: Clinical Gastroenterology and Hepatology
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Youngkyu Park, Keith Rivera, Wilhelm Palm, John Wilson, Vineet Sangar, Yuan Hao, Daniel Öhlund, Kevin Wright, Dea Filippini, Eun Jung Lee, Brandon Da Silva, Christina Schoepfer, John Erby Wilkinson, Jonathan M Buscaglia, Gina M DeNicola, Herve Tiriac, Molly Hammell, Howard C Crawford, Edward E Schmidt, Craig B Thompson, Darryl J Pappin, Nahum Sonenberg, David A Tuveson
Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells...
August 11, 2016: Cell
Mohammad F Madhoun, Gregory A Cote, Sushil K Ahlawat, Nuzhat A Ahmad, Jonathan M Buscaglia, Audrey H Calderwood, Seth Crockett, Dayna S Early, Ferga C Gleeson, Suryakanth R Gurudu, Thomas F Imperiale, Julia J Liu, Patrick Mosler, Rahul Pannala, Patrick R Pfau, Joseph Romagnuolo, Jewel Samadder, Amrita Sethi, Amandeep K Shergill, Eun J Shin, Field Willingham, Jason A Dominitz
BACKGROUND AND AIMS: Since 1985, the American Society for Gastrointestinal Endoscopy (ASGE) has awarded grants for endoscopic-related research. The goals of this study were to examine trends in ASGE grant funding and to assess productivity of previous recipients of the ASGE grant awards. METHODS: This was a retrospective cohort analysis of all research grants awarded by the ASGE through 2009. Measures of academic productivity and self-assessment of the ASGE awards' impact on the recipients' careers were defined by using publicly available resources (eg, National Library of Medicine-PubMed) and administration of an electronic survey to award recipients...
September 2016: Gastrointestinal Endoscopy
Yingjie Yu, Qi Zhang, Jonathan Buscaglia, Chung-Chueh Chang, Ying Liu, Zhenhua Yang, Yichen Guo, Yantian Wang, Kalle Levon, Miriam Rafailovich
In this study, a sensitive, yet robust, biosensing system with real-time electrochemical readout was developed. The biosensor system was applied to the detection of carcinoembryonic antigen (CEA), which is a common marker for many cancers such as pancreatic, breast, and colon cancer. Real time detection of CEA during a medical procedure can be used to make critical decisions regarding further surgical intervention. CEA was templated on gold surface (RMS roughness ∼3-4 nm) coated with a hydrophilic self-assembled monolayer (SAM) on the working electrode of an open circuit potentiometric network...
July 21, 2016: Analyst
Chris Lascarides, Jonathan M Buscaglia, Paula I Denoya, Satish Nagula, Juan Carlos Bucobo, Roberto Bergamaschi
AIM: An RCT was conducted to test the null hypothesis that there is no difference in complication rates and length of stay (LOS) between laparoscopic right colectomy (LRC) and laparoscopic-assisted colonoscopic polypectomy (LACP) for endoscopically unresectable polyps of the right colon. METHOD: A single-centre RCT (NCT01986699) was conducted on patients with polyps of the right colon deemed non-resectable by the gastroenterologist. They underwent a repeat colonoscopy with biopsy by an interventional endoscopist and were allocated to LRC or LACP...
April 1, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Mohamed O Othman, Jonathan M Buscaglia
No abstract text is available yet for this article.
April 2016: Clinical Gastroenterology and Hepatology
Jennifer Hsieh, Amar Thosani, Matthew Grunwald, Satish Nagula, Juan Carlos Bucobo, Jonathan M Buscaglia
Controversy exists over the need for unilateral versus bilateral stent placement in patients with malignant obstruction at the biliary hilum. Placement of bilateral uncovered self-expanding metal stent (UCSEMS) at this location is technically challenging, and generally associated with lower rates of procedural success. Serial insertion of side-by-side UCSEMS may be especially difficult when simultaneous deployment is not possible using larger stent delivery catheters. In this single-center, retrospective case series of all patients who underwent bilateral placement of uncovered Wallflex(TM) biliary stents between July 2008 and July 2014, we evaluate the feasibility, technical success, and safety of patients undergoing serial insertion of bilateral UCSEMS using the 8 Fr Wallflex(TM) biliary system for malignant hilar obstruction...
October 2015: Hepatobiliary Surgery and Nutrition
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Stephen Hasak, Srinivas Gaddam, Steven A Edmundowicz, Mark A Gromski, John M DeWitt, Mohamad El Zein, Mouen A Khashab, Andrew Y Wang, Jonathan P Gaspar, Dushant S Uppal, Satish Nagula, Samir Kapadia, Jonathan M Buscaglia, Juan Carlos Bucobo, Alex Schlachterman, Mihir S Wagh, Peter V Draganov, Min Kyu Jung, Tyler Stevens, John J Vargo, Harshit S Khara, Mustafa Huseini, David L Diehl, Rajesh N Keswani, Ryan Law, Srinadh Komanduri, Patrick S Yachimski, Tomas DaVee, Anoop Prabhu, Robert T Lapp, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Natasha Chhabra, Wallace J Wang, Petros Benias, David L Carr-Locke, Christopher J DiMaio
BACKGROUND AND AIMS: The need for transpapillary drainage (TPD) in patients undergoing transmural drainage (TMD) of pancreatic fluid collections (PFCs) remains unclear. The aims of this study were to compare treatment outcomes between patients with pancreatic pseudocysts undergoing TMD versus combined (TMD and TPD) drainage (CD) and to identify predictors of symptomatic and radiologic resolution. METHODS: This is a retrospective review of 375 consecutive patients with PFCs who underwent EUS-guided TMD from 2008 to 2014 at 15 academic centers in the United States...
April 2016: Gastrointestinal Endoscopy
Jonathan M Buscaglia
No abstract text is available yet for this article.
December 2015: Clinical Gastroenterology and Hepatology
Payal Saxena, David L Diehl, Vivek Kumbhari, Frederick Shieh, Jonathan M Buscaglia, Wilson Sze, Sumit Kapoor, Srinadh Komanduri, John Nasr, Eun Ji Shin, Vikesh Singh, Anne Marie Lennon, Anthony N Kalloo, Mouen A Khashab
BACKGROUND: Endoscopic therapy is considered first line for management of benign biliary strictures (BBSs). Placement of plastic stents has been effective but limited by their short-term patency and need for repeated procedures. Fully covered self-expandable metallic stents (FCSEMSs) offer longer-lasting biliary drainage without the need for frequent exchanges. AIMS: The aim of this study was to assess the efficacy and safety of FCSEMS in patients with BBS. METHODS: A retrospective review of all patients who underwent ERCP and FCSEMS placement at five tertiary referral US hospitals was performed...
November 2015: Digestive Diseases and Sciences
Field F Willingham, Jonathan M Buscaglia
Gastrointestinal leaks and fistulae can be serious acute complications or chronic morbid conditions resulting from inflammatory, malignant, or postsurgical states. Endoscopic closure of gastrointestinal leaks and fistulae represents major progress in the treatment of patients with these complex presentations. The main goal of endoscopic therapy is the interruption of the flow of luminal contents across a gastrointestinal defect. In consideration of the proper endoscopic approach to luminal closure, several basic principles must be considered...
October 2015: Clinical Gastroenterology and Hepatology
J M Buscaglia, J Fakhoury, J Loyal, P I Denoya, E Kazi, S A Stein, R Scriven, R Bergamaschi
AIM: Surgery residents are required to become proficient in colonoscopy before completing training. The aim of this study was to evaluate the responsiveness of surgery interns to simulated colonoscopy training. METHOD: Interns, defined as postgraduate year 1 residents without exposure to endoscopy, underwent training in a physical model including colonoscopy, synthetic anatomy trays with luminal tattoos and a hybrid simulator. After baseline testing and mentored training, final testing was performed using five predetermined proficiency criteria...
June 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Jonathan B Chaires, John O Trent, Robert D Gray, William L Dean, Robert Buscaglia, Shelia D Thomas, Donald M Miller
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic properties and stability...
2014: PloS One
Christopher J DiMaio, Jonathan M Buscaglia, Seth A Gross, Harry R Aslanian, Adam J Goodman, Sammy Ho, Michelle K Kim, Shireen Pais, Felice Schnoll-Sussman, Amrita Sethi, Uzma D Siddiqui, David H Robbins, Douglas G Adler, Satish Nagula
AIM: To ascertain fine needle aspiration (FNA) techniques by endosonographers with varying levels of experience and environments. METHODS: A survey study was performed on United States based endosonographers. The subjects completed an anonymous online electronic survey. The main outcome measurements were differences in needle choice, FNA technique, and clinical decision making among endosonographers and how this relates to years in practice, volume of EUS-FNA procedures, and practice environment...
October 16, 2014: World Journal of Gastrointestinal Endoscopy
Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo
No abstract text is available yet for this article.
September 2014: Gastrointestinal Endoscopy
Joo Hyun O, Martin A Lodge, Sanjay Jagannath, Jonathan M Buscaglia, Yetunde Olagbemiro, Richard L Wahl
UNLABELLED: The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. METHODS: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic (11)C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed...
July 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Laila Menon, Jonathan M Buscaglia
Endoscopy and endoscopic ultrasound (EUS) play a critical role in the detection and management of subepithelial lesions of the gastrointestinal tract. The most common subepithelial lesions detected by endoscopists are gastrointestinal stromal tumors (GISTs), leiomyomas, lipomas, granular cell tumors (GCTs), pancreatic rests and carcinoid tumors. These lesions can be classified based on unique histochemical staining and the gastrointestinal layer of origin. While the majority of the lesions are considered benign, some tumors such as GISTs and carcinoids have a strong propensity for malignant transformation...
May 2014: Therapeutic Advances in Gastroenterology
Huy T Le, William L Dean, Robert Buscaglia, Jonathan B Chaires, John O Trent
Guanine-rich oligonucleotides can adopt noncanonical tertiary structures known as G-quadruplexes, which can exist in different forms depending on experimental conditions. High-resolution structural methods, such as X-ray crystallography and NMR spectroscopy, have been of limited usefulness in resolving the inherent structural polymorphism associated with G-quadruplex formation. The lack of, or the ambiguous nature of, currently available high-resolution structural data, in turn, has severely hindered investigations into the nature of these structures and their interactions with small-molecule inhibitors...
May 22, 2014: Journal of Physical Chemistry. B
Michael J Clores, Amar Thosani, Jonathan M Buscaglia
Pancreatic cystic lesions are commonly encountered today with the routine use of cross-sectional imaging modalities such as computed tomography (CT) and magnetic resonance imaging (MRI). The majority of patients discovered to have a pancreatic cyst are completely asymptomatic; yet the presence of such a finding instills fear in the minds of both patient and physician, as the concern for malignant transformation to pancreatic cancer is great despite the relatively low overall likelihood of cyst progression. Not all cysts in the pancreas represent pancreatic cystic neoplasms (PCNs), and not all PCNs have significant malignant potential...
2014: Journal of Multidisciplinary Healthcare
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