keyword
MENU ▼
Read by QxMD icon Read
search

Jonathan Buscaglia

keyword
https://www.readbyqxmd.com/read/28757253/enhancer-reprogramming-promotes-pancreatic-cancer-metastasis
#1
Jae-Seok Roe, Chang-Il Hwang, Tim D D Somerville, Joseph P Milazzo, Eun Jung Lee, Brandon Da Silva, Laura Maiorino, Hervé Tiriac, C Megan Young, Koji Miyabayashi, Dea Filippini, Brianna Creighton, Richard A Burkhart, Jonathan M Buscaglia, Edward J Kim, Jean L Grem, Audrey J Lazenby, James A Grunkemeyer, Michael A Hollingsworth, Paul M Grandgenett, Mikala Egeblad, Youngkyu Park, David A Tuveson, Christopher R Vakoc
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model. This approach revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity. We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanism that renders PDA cells more invasive and less anchorage-dependent for growth in vitro, as well as more metastatic in vivo...
July 25, 2017: Cell
https://www.readbyqxmd.com/read/28624647/comparing-endoscopic-ultrasound-fine-needle-aspiration-and-endoscopic-ultrasound-fine-needle-biopsy-for-solid-lesions-a%C3%A2-multicenter-randomized-trial-the-new-york-endoscopic-research-outcomes-group-nyero
#2
Satish Nagula, Kamron Pourmand, Harry Aslanian, Juan Carlos Bucobo, Tamas Gonda, Susana Gonzalez, Adam Goodman, Seth A Gross, Sammy Ho, Christopher J DiMaio, Michelle Kim, Shireen Pais, John Poneros, David Robbins, Felice Schnoll-Sussman, Amrita Sethi, Jonathan M Buscaglia
BACKGROUND & AIMS: Endoscopic ultrasound with fine-needle aspiration (FNA) is the standard of care for tissue sampling of solid lesions adjacent to the gastrointestinal tract. Fine-needle biopsy (FNB) may provide higher diagnostic yield with fewer needle passes. The aim of this study was to assess the difference in diagnostic yield between FNA and FNB. METHODS: This is a multicenter, prospective randomized clinical trial from 6 large tertiary care centers. Patients referred for tissue sampling of solid lesions were randomized to either FNA or FNB of the target lesion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28210709/clinical-outcomes-of-eus-guided-drainage-of-debris-containing-pancreatic-pseudocysts-a-large-multicenter-study
#3
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Steven A Edmundowicz, John M DeWitt, Mouen A Khashab, Andrew Y Wang, Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo, Mihir S Wagh, Peter V Draganov, Tyler Stevens, John J Vargo, Harshit S Khara, David L Diehl, Rajesh N Keswani, Srinadh Komanduri, Patrick S Yachimski, Anoop Prabhu, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Petros Benias, David L Carr-Locke, Christopher J DiMaio
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28161287/issue-highlights
#4
Jonathan M Buscaglia
No abstract text is available yet for this article.
February 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28114688/lumen-apposing-covered-self-expandable-metal-stents-for-short-benign-gastrointestinal-strictures-a-multicenter-study
#5
Dennis Yang, Jose M Nieto, Ali Siddiqui, Brian P Riff, Christopher J DiMaio, Satish Nagula, Amr M Ismail, Saowanee Ngamreungphong, Mouen A Khashab, Mihir S Wagh, Demetrios Tzimas, Jonathan M Buscaglia, Daniel S Strand, Andrew Y Wang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
Background and study aim Use of the fully covered self-expandable metal stent (SEMS) for benign luminal gastrointestinal (GI) stricture (BLGS) has been limited by the migration rate. The role of the lumen-apposing metal stent (LAMS) for BLGS is not well defined. We assessed the safety, feasibility, and efficacy of LAMS for the treatment of BLGS. Patients and methods This was an observational, open-label, retrospective, single-arm, multicenter consecutive case series of patients undergoing LAMS placement for BLGS...
April 2017: Endoscopy
https://www.readbyqxmd.com/read/28089065/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#6
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28069113/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#7
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
February 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27714511/interventional-eus-using-a-flexible-19-gauge-needle-an-international-multicenter-experience-in-162-patients
#8
MULTICENTER STUDY
Vivek Kumbhari, Irene Peñas, Alan H Tieu, Carlos De la Serna-Higuera, Manie Juneja, Fuad Maufa, Saowanee Ngamruengphong, Mohamad H El-Zein, Nadim Haddad, Sandeep Krishnan, Susana Gonzalez, Peter V Renny, Payal Saxena, Linda Howard, Christopher J DiMaio, Jonathan M Buscaglia, Manuel Perez-Miranda, Mouen A Khashab
BACKGROUND AND AIMS: To facilitate access for interventional EUS, flexible (nitinol) 19-G needles have been introduced to permit needle puncture even when the echoendoscope is in an angulated position, such as in the second part of the duodenum. The aims of the study were to evaluate the performance of a flexible 19-G needle during interventional EUS procedures and compare outcomes when the echoendoscope was in the straight versus angulated position. METHODS: A retrospective review was undertaken of 162 consecutive patients that underwent a variety of interventional EUS procedures with a flexible 19-G needle across five centers...
December 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27520399/issue-highlights
#9
Jonathan M Buscaglia
No abstract text is available yet for this article.
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27477511/nrf2-promotes-tumor-maintenance-by-modulating-mrna-translation-in-pancreatic-cancer
#10
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Youngkyu Park, Keith Rivera, Wilhelm Palm, John Wilson, Vineet Sangar, Yuan Hao, Daniel Öhlund, Kevin Wright, Dea Filippini, Eun Jung Lee, Brandon Da Silva, Christina Schoepfer, John Erby Wilkinson, Jonathan M Buscaglia, Gina M DeNicola, Herve Tiriac, Molly Hammell, Howard C Crawford, Edward E Schmidt, Craig B Thompson, Darryl J Pappin, Nahum Sonenberg, David A Tuveson
Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells...
August 11, 2016: Cell
https://www.readbyqxmd.com/read/27349928/impact-and-outcomes-of-research-sponsored-by-the-american-society-for-gastrointestinal-endoscopy
#11
Mohammad F Madhoun, Gregory A Cote, Sushil K Ahlawat, Nuzhat A Ahmad, Jonathan M Buscaglia, Audrey H Calderwood, Seth Crockett, Dayna S Early, Ferga C Gleeson, Suryakanth R Gurudu, Thomas F Imperiale, Julia J Liu, Patrick Mosler, Rahul Pannala, Patrick R Pfau, Joseph Romagnuolo, Jewel Samadder, Amrita Sethi, Amandeep K Shergill, Eun J Shin, Field Willingham, Jason A Dominitz
BACKGROUND AND AIMS: Since 1985, the American Society for Gastrointestinal Endoscopy (ASGE) has awarded grants for endoscopic-related research. The goals of this study were to examine trends in ASGE grant funding and to assess productivity of previous recipients of the ASGE grant awards. METHODS: This was a retrospective cohort analysis of all research grants awarded by the ASGE through 2009. Measures of academic productivity and self-assessment of the ASGE awards' impact on the recipients' careers were defined by using publicly available resources (eg, National Library of Medicine-PubMed) and administration of an electronic survey to award recipients...
September 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27193921/quantitative-real-time-detection-of-carcinoembryonic-antigen-cea-from-pancreatic-cyst-fluid-using-3-d-surface-molecular-imprinting
#12
Yingjie Yu, Qi Zhang, Jonathan Buscaglia, Chung-Chueh Chang, Ying Liu, Zhenhua Yang, Yichen Guo, Yantian Wang, Kalle Levon, Miriam Rafailovich
In this study, a sensitive, yet robust, biosensing system with real-time electrochemical readout was developed. The biosensor system was applied to the detection of carcinoembryonic antigen (CEA), which is a common marker for many cancers such as pancreatic, breast, and colon cancer. Real time detection of CEA during a medical procedure can be used to make critical decisions regarding further surgical intervention. CEA was templated on gold surface (RMS roughness ∼3-4 nm) coated with a hydrophilic self-assembled monolayer (SAM) on the working electrode of an open circuit potentiometric network...
July 21, 2016: Analyst
https://www.readbyqxmd.com/read/27038277/laparoscopic-right-colectomy-vs-laparoscopic-assisted-colonoscopic-polypectomy-for-endoscopically-unresectable-polyps-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
C Lascarides, J M Buscaglia, P I Denoya, S Nagula, J C Bucobo, R Bergamaschi
AIM: A randomized controlled trial (RCT) was conducted to test the null hypothesis that there is no difference in complication rates and length of stay (LOS) between laparoscopic right colectomy (LRC) and laparoscopic-assisted colonoscopic polypectomy (LACP) for endoscopically unresectable polyps of the right colon. METHOD: A single-centre RCT (NCT01986699) was conducted on patients with polyps of the right colon deemed by the gastroenterologist to be unresectable...
November 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/26713890/get-ready-to-meet-the-growing-demand-from-patients-with-pancreatic-cysts
#14
EDITORIAL
Mohamed O Othman, Jonathan M Buscaglia
No abstract text is available yet for this article.
April 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26605283/serial-insertion-of-bilateral-uncovered-metal-stents-for-malignant-hilar-obstruction-using-an-8-fr-biliary-system-a-case-series-of-17-consecutive-patients
#15
Jennifer Hsieh, Amar Thosani, Matthew Grunwald, Satish Nagula, Juan Carlos Bucobo, Jonathan M Buscaglia
Controversy exists over the need for unilateral versus bilateral stent placement in patients with malignant obstruction at the biliary hilum. Placement of bilateral uncovered self-expanding metal stent (UCSEMS) at this location is technically challenging, and generally associated with lower rates of procedural success. Serial insertion of side-by-side UCSEMS may be especially difficult when simultaneous deployment is not possible using larger stent delivery catheters. In this single-center, retrospective case series of all patients who underwent bilateral placement of uncovered Wallflex(TM) biliary stents between July 2008 and July 2014, we evaluate the feasibility, technical success, and safety of patients undergoing serial insertion of bilateral UCSEMS using the 8 Fr Wallflex(TM) biliary system for malignant hilar obstruction...
October 2015: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/26548849/transpapillary-drainage-has-no-added-benefit-on-treatment-outcomes-in-patients-undergoing-eus-guided-transmural-drainage-of-pancreatic-pseudocysts-a-large-multicenter-study
#16
MULTICENTER STUDY
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Stephen Hasak, Srinivas Gaddam, Steven A Edmundowicz, Mark A Gromski, John M DeWitt, Mohamad El Zein, Mouen A Khashab, Andrew Y Wang, Jonathan P Gaspar, Dushant S Uppal, Satish Nagula, Samir Kapadia, Jonathan M Buscaglia, Juan Carlos Bucobo, Alex Schlachterman, Mihir S Wagh, Peter V Draganov, Min Kyu Jung, Tyler Stevens, John J Vargo, Harshit S Khara, Mustafa Huseini, David L Diehl, Rajesh N Keswani, Ryan Law, Srinadh Komanduri, Patrick S Yachimski, Tomas DaVee, Anoop Prabhu, Robert T Lapp, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Natasha Chhabra, Wallace J Wang, Petros Benias, David L Carr-Locke, Christopher J DiMaio
BACKGROUND AND AIMS: The need for transpapillary drainage (TPD) in patients undergoing transmural drainage (TMD) of pancreatic fluid collections (PFCs) remains unclear. The aims of this study were to compare treatment outcomes between patients with pancreatic pseudocysts undergoing TMD versus combined (TMD and TPD) drainage (CD) and to identify predictors of symptomatic and radiologic resolution. METHODS: This is a retrospective review of 375 consecutive patients with PFCs who underwent EUS-guided TMD from 2008 to 2014 at 15 academic centers in the United States...
April 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26459037/issue-highlights
#17
Jonathan M Buscaglia
No abstract text is available yet for this article.
December 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25850628/a-us-multicenter-study-of-safety-and-efficacy-of-fully-covered-self-expandable-metallic-stents-in-benign-extrahepatic-biliary-strictures
#18
MULTICENTER STUDY
Payal Saxena, David L Diehl, Vivek Kumbhari, Frederick Shieh, Jonathan M Buscaglia, Wilson Sze, Sumit Kapoor, Srinadh Komanduri, John Nasr, Eun Ji Shin, Vikesh Singh, Anne Marie Lennon, Anthony N Kalloo, Mouen A Khashab
BACKGROUND: Endoscopic therapy is considered first line for management of benign biliary strictures (BBSs). Placement of plastic stents has been effective but limited by their short-term patency and need for repeated procedures. Fully covered self-expandable metallic stents (FCSEMSs) offer longer-lasting biliary drainage without the need for frequent exchanges. AIMS: The aim of this study was to assess the efficacy and safety of FCSEMS in patients with BBS. METHODS: A retrospective review of all patients who underwent ERCP and FCSEMS placement at five tertiary referral US hospitals was performed...
November 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/25697628/endoscopic-management-of-gastrointestinal-leaks-and-fistulae
#19
REVIEW
Field F Willingham, Jonathan M Buscaglia
Gastrointestinal leaks and fistulae can be serious acute complications or chronic morbid conditions resulting from inflammatory, malignant, or postsurgical states. Endoscopic closure of gastrointestinal leaks and fistulae represents major progress in the treatment of patients with these complex presentations. The main goal of endoscopic therapy is the interruption of the flow of luminal contents across a gastrointestinal defect. In consideration of the proper endoscopic approach to luminal closure, several basic principles must be considered...
October 2015: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/25537052/simulated-colonoscopy-training-using-a-low-cost-physical-model-improves-responsiveness-of-surgery-interns
#20
J M Buscaglia, J Fakhoury, J Loyal, P I Denoya, E Kazi, S A Stein, R Scriven, R Bergamaschi
AIM: Surgery residents are required to become proficient in colonoscopy before completing training. The aim of this study was to evaluate the responsiveness of surgery interns to simulated colonoscopy training. METHOD: Interns, defined as postgraduate year 1 residents without exposure to endoscopy, underwent training in a physical model including colonoscopy, synthetic anatomy trays with luminal tattoos and a hybrid simulator. After baseline testing and mentored training, final testing was performed using five predetermined proficiency criteria...
June 2015: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
keyword
keyword
47738
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"