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JOURNAL ARTICLE
Terry C Yin, Jonathan G Van Vranken, Dhiraj Srivastava, Ayushi Mittal, Paul Buscaglia, Autumn E Moore, Jissele A Verdinez, Aschleigh E Graham, Susan A Walsh, Michael A Acevedo, Robert J Kerns, Nikolai O Artemyev, Steven P Gygi, Julien A Sebag
Insulin resistance (IR) is the root cause of type II diabetes, yet no safe treatment is available to address it. Using a high throughput compatible assay that measures real-time translocation of the glucose transporter glucose transporter 4 (GLUT4), we identified small molecules that potentiate insulin action. In vivo, these insulin sensitizers improve insulin-stimulated GLUT4 translocation, glucose tolerance, and glucose uptake in a model of IR. Using proteomic and CRISPR-based approaches, we identified the targets of those compounds as Unc119 proteins and solved the structure of Unc119 bound to the insulin sensitizer...
June 28, 2023: Cell Chemical Biology
#2
JOURNAL ARTICLE
Danse Bi, Linda Y Zhang, Mohammad Alqaisieh, Apurva Shrigiriwar, Jad Farha, Tala Mahmoud, Karl Akiki, Antonio Almario Jose, Sardar M Shah-Khan, Stuart R Gordon, Jeffrey M Adler, Mark Radetic, Peter V Draganov, Yakira N David, Brianna Shinn, Zahraa Mohammed, Alexander Schlachterman, Sofia Yuen, Ahmad Al-Taee, Namn Yunseok, Roberto Trasolini, Michael Bejjani, Bachir Ghandour, Hemchand Ramberan, Andrew Canakis, Saowanee Ngamruengphong, Andrew C Storm, Shailendra Singh, Heiko Pohl, Juan Carlos Bucobo, Jonathan M Buscaglia, Lionel S D'Souza, Bashar Qumseya, Nikhil A Kumta, Anand Kumar, Gregory B Haber, Aihara Hiroyuki, Mandeep Sawhney, Raymond Kim, Tyler M Berzin, Mouen A Khashab
BACKGROUND AND AIMS: Large colon polyps removed by endoscopic mucosal resection (EMR) can be complicated by delayed bleeding. Prophylactic defect clip closure can reduce post-EMR bleeding. Larger defects can be challenging to close using through-the-scope clips (TTSCs) and proximal defects are difficult to reach using over-the-scope techniques. A novel, through-the-scope suture (TTSS) device allows direct closure of mucosal defects without scope withdrawal. We aim to evaluate the rate of delayed bleeding following the closure of large colon polyp EMR sites with TTSS...
March 6, 2023: Gastrointestinal Endoscopy
#3
JOURNAL ARTICLE
Rubin Jf Ramos, Chencan Zhu, Dimitri F Joseph, Shubh Thaker, Joseph F Lacomb, Katherine Markarian, Hannah J Lee, Jessica C Petrov, Farah Monzur, Jonathan M Buscaglia, Anupama Chawla, Leslie Small-Harary, Grace Gathungu, Jeffrey A Morganstern, Jie Yang, Jinyu Li, Eric G Pamer, Charles E Robertson, Daniel N Frank, Justin R Cross, Ellen Li
BACKGROUND: Fecal microbiota transplantation (FMT) is an effective treatment of recurrent Clostridioides difficile infections (rCDI), but has more limited efficacy in treating either ulcerative colitis (UC) or Crohn's disease (CD), two major forms of inflammatory bowel diseases (IBD). We hypothesize that FMT recipients with rCDI and/or IBD have baseline fecal bile acid (BA) compositions that differ significantly from that of their healthy donors and that FMT will normalize the BA compositions...
October 31, 2022: Medical Research Archives
#4
JOURNAL ARTICLE
Jad Farha, Hemchand Ramberan, Hiroyuki Aihara, Linda Y Zhang, Amit Mehta, Camille Hage, Alexander Schlachterman, Anand Kumar, Brianna Shinn, Andrew Canakis, Raymond Eunho Kim, Lionel S D'Souza, Jonathan Buscaglia, Andrew C Storm, Jason Samarasena, Kenneth Chang, Shai Friedland, Peter V Dragonov, Bashar Qumseya, Salmaan Jawaid, Mohamed O Othman, Muhammad Khalid Hasan, Dennis Yang, Mouen A Khashab, Saowanee Ngamruengphong
BACKGROUND: Complete closure of large mucosal defects following colorectal ESD with through-the-scope clips (TTSC) is oftentimes not possible. We aimed to report an early experience of using a novel through-the-scope suturing system (TTSS) for closing large mucosal defects after colorectal ESD. METHODS: We performed a retrospective, multi-center cohort study of consecutive patients who underwent attempted prophylactic defect closure using TTSS after colorectal ESD...
November 2, 2022: Endoscopy
#5
EDITORIAL
Isaiah P Schuster, Jonathan M Buscaglia
No abstract text is available yet for this article.
May 11, 2022: Clinical Gastroenterology and Hepatology
#6
Mohammad Noubani, Rohit Bhan, Nimra Ghani, Pons Materum, Emily Glazer, Georgios Georgakis, Jonathan M Buscaglia
We describe a case of an inverted Meckel's diverticulum presenting as an intraluminal subepithelial lesion on intraoperative enteroscopy. A 53-year-old woman presented with chronic iron deficiency anemia unresponsive to escalating iron supplementation. After equivocal upper and lower endoscopy and negative cross-sectional imaging, capsule endoscopy suggested a submucosal mass lesion in the proximal ileum. Antegrade double-balloon enteroscopy was unsuccessful in reaching the lesion. A large pedunculated, submucosal-appearing lesion was finally identified on intraoperative enteroscopy...
May 2022: ACG Case Reports Journal
#7
MULTICENTER STUDY
Petros C Benias, Sumant Inamdar, Diana Wee, Yan Liu, Jonathan M Buscaglia, Sanjaya K Satapathy, Arvind J Trindade
OBJECTIVES: Coronavirus disease 2019 (COVID-19) patients may have varying degrees of hyperlipasemia. The aim was to compare outcomes among different levels of hyperlipasemia in patients with COVID-19. METHODS: This is a retrospective study examining outcomes among hospitalized COVID-19 patients with a lipase <3× upper limit of normal (ULN), asymptomatic hyperlipasemia (>3× ULN), secondary pancreatitis (typical respiratory COVID-19 symptoms and found to have pancreatitis), and primary pancreatitis (presenting with pancreatitis)...
October 1, 2021: Pancreas
#8
JOURNAL ARTICLE
Benjamin D Renelus, Devika Dixit, Phuong T Nguyen, Kingsley K Njoku, Parth B Patel, Katiria Pintor-Jimenez, Fengxia Yan, Jonathan M Buscaglia, Kevin E Woods, Daniel S Jamorabo
BACKGROUND: Chemoprevention of colorectal neoplasia with aspirin and statins is under-investigated in Black patients. Since Black patients suffer disproportionately from colon cancer incidence and mortality compared to other populations, we investigated the utility of aspirin and statin in reducing advanced adenomatous polyp (AAP) risk in Black patients. METHODS: We carried out a retrospective cohort study of screening colonoscopies performed at a large urban academic center from 1/1/2011 through 12/31/2019...
October 17, 2021: BMC Gastroenterology
#9
JOURNAL ARTICLE
Daniel S Jamorabo, Vasilios Koulouris, William M Briggs, Jonathan M Buscaglia, Benjamin D Renelus
BACKGROUND: Publications are an important component of academic careers. AIMS: We investigated the financial costs to authors for submitting and publishing manuscripts in gastroenterology (GI) journals in the United States (US), United Kingdom (UK), and elsewhere. METHODS: This was a cross-sectional study carried out from 11/1/2020 to 12/31/2020. We used the SCImago Journal and Country Rankings site to compile a list of gastroenterology and hepatology journals to analyze...
September 9, 2021: Digestive Diseases and Sciences
#10
JOURNAL ARTICLE
Lucia Roa-Peña, Sruthi Babu, Cindy V Leiton, Maoxin Wu, Sofia Taboada, Ali Akalin, Jonathan Buscaglia, Luisa F Escobar-Hoyos, Kenneth R Shroyer
BACKGROUND: Although pancreatic ductal adenocarcinoma (PDAC) has one of the lowest 5-year survival rates of all cancers, differences in survival exist between patients with clinically identical characteristics. The authors previously demonstrated that keratin 17 (K17) expression in PDAC, measured by RNA sequencing or immunohistochemistry (IHC), is an independent negative prognostic biomarker. Only 20% of cases are candidates for surgical resection, but most patients are diagnosed by needle aspiration biopsy (NAB)...
June 2, 2021: Cancer Cytopathology
#11
JOURNAL ARTICLE
Dimitri F Joseph, Ellen Li, Samuel L Stanley Iii, Yi-Cong Zhu, Xiao-Ning Li, Jie Yang, Lorenzo F Ottaviano, Juan Carlos Bucobo, Jonathan M Buscaglia, Joshua D Miller, Rajesh Veluvolu, Michele Follen, Evan B Grossman
BACKGROUND: The Black/African Ancestry (AA) population has a higher prevalence of type 2 diabetes mellitus (T2DM) and a higher incidence and mortality rate for colorectal cancer (CRC) than all other races in the United States. T2DM has been shown to increase adenoma risk in predominantly white/European ancestry (EA) populations, but the effect of T2DM on adenoma risk in Black/AA individuals is less clear. We hypothesize that T2DM has a significant effect on adenoma risk in a predominantly Black/AA population...
April 16, 2021: World Journal of Clinical Cases
#12
EDITORIAL
Jonathan M Buscaglia, Chang Lin
No abstract text is available yet for this article.
December 30, 2020: Clinical Gastroenterology and Hepatology
#13
JOURNAL ARTICLE
Srihari Mahadev, Olga C Aroniadis, Luis H Barraza, Emil Agarunov, Michael S Smith, Adam J Goodman, Petros C Benias, Jonathan M Buscaglia, Seth A Gross, Franklin Kasmin, Jonathan Cohen, David L Carr-Locke, David Greenwald, Robin Mendelsohn, Amrita Sethi, Tamas A Gonda
Background and study aims The coronavirus disease 2019 (COVID-19), and measures taken to mitigate its impact, have profoundly affected the clinical care of gastroenterology patients and the work of endoscopy units. We aimed to describe the clinical care delivered by gastroenterologists and the type of procedures performed during the early to peak period of the pandemic. Methods Endoscopy leaders in the New York region were invited to participate in an electronic survey describing operations and clinical service...
December 2020: Endoscopy International Open
#14
JOURNAL ARTICLE
Christopher Lawrence, Jose Nieto, Willis G Parsons, André Roy, Nalini M Guda, Stephen E Steinberg, Muhammad K Hasan, Juan Carlos Bucobo, Satish Nagula, Nicholas D Dey, Jonathan M Buscaglia
BACKGROUND: Biliary decompression can reduce symptoms and improve quality of life in patients with malignant biliary obstruction. Endoscopically placed stents have become the standard of care for biliary drainage with the aim of improving hepatic function, relieving jaundice, and reducing adverse effects of obstruction. The purpose of this study was to evaluate the performance characteristics of a newly-designed, uncovered metal biliary stent for the palliation of malignant biliary obstruction...
June 10, 2020: BMC Gastroenterology
#15
RANDOMIZED CONTROLLED TRIAL
B Joseph Elmunzer, Zachary L Smith, Paul Tarnasky, Andrew Y Wang, Patrick Yachimski, Filip Banovac, Jonathan M Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A Coté, Peter V Draganov, Kulwinder Dua, Valerie Durkalski, Brian S Geller, Laith H Jamil, Rajesh N Keswani, Mouen A Khashab, Ryan Law, Simon K Lo, Sean McCarthy, J Bayne Selby, Vikesh K Singh, Jason R Taylor, Field F Willingham, Rebecca L Spitzer, Lydia D Foster
Percutaneous transhepatic biliary drainage (PTBD) and endoscopic retrograde cholangiopancreatography (ERCP) are widely accepted but competing approaches for the management of malignant obstruction at the hilum of the liver. ERCP is favored in the United States on the basis of high success rates for non-hilar indications, the perceived safety and superior tissue sampling capability of ERCP relative to PTBD, and the avoidance of external drains that are undesirable to patients. A recent randomized controlled trial (RCT) comparing the 2 modalities in patients with resectable hilar cholangiocarcinoma was terminated prematurely because of higher mortality in the PTBD group...
June 2021: Clinical Gastroenterology and Hepatology
#16
JOURNAL ARTICLE
Lorenzo F Ottaviano, Xueying Li, Matthew Murray, Jesse T Frye, Brandon E Lung, Ying Yi Zhang, Jie Yang, Erin M Taub, Juan Carlos Bucobo, Jonathan M Buscaglia, Ellen Li, Joshua D Miller
BACKGROUND: Diabetes is associated with an increased risk of colorectal cancer (CRC). We conducted a retrospective analysis of adenoma detection rates (ADR) in initial screening colonoscopies to further investigate the role of diabetes in adenoma detection. METHODS: A chart review was performed on initial average risk screening colonoscopies (ages 45-75) during 2012-2015. Data collected included basic demographics, insurance, BMI, family history of CRC, smoking, diabetes, and aspirin use...
May 8, 2020: Scientific Reports
#17
JOURNAL ARTICLE
Joseph F Lacomb, Dennis Plenker, Hervé Tiriac, Juan Carlos Bucobo, Lionel S D'souza, Asim S Khokhar, Hardik Patel, Breana Channer, Dimitri Joseph, Maoxin Wu, David A Tuveson, Ellen Li, Jonathan M Buscaglia
Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses of all malignancies, with a 5-year survival rate <8%.1 , 2 Suspicious lesions are typically diagnosed via endoscopic ultrasound-guided fine-needle aspiration or endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB).3 Fewer needle passes decreases the risk of postprocedure complications, including pancreatitis and hemorrhage, while allowing additional needle passes to be used for adjuvant tissue testing, such as organoid creation and DNA sequencing...
February 29, 2020: Clinical Gastroenterology and Hepatology
#18
JOURNAL ARTICLE
Reem Z Sharaiha, Aleksey Novikov, Kristen Weaver, Pawan Marfatia, Jonathan M Buscaglia, Christopher J DiMaio, David Diehl, Moamen M Gabr, Monica Gaidhane, Ali Siddiqui, Michel Kahaleh
Background and study aims Fully covered self-expanding metal stents (FCSEMS) have been used to treat refractory pancreatic duct strictures. We aimed to evaluate the feasibility, safety, and efficacy of FCSEMS in chronic pancreatitis with refractory pancreatic duct strictures. Patients and methods This was a retrospective multicenter cases series of patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) with FCSEMS placement in the main pancreatic duct (MPD) at five tertiary care centers between February 2010 and June 2016...
November 2019: Endoscopy International Open
#19
EDITORIAL
Galen Leung, Jonathan M Buscaglia
No abstract text is available yet for this article.
April 2020: Clinical Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Michael J Clores, Juan Carlos Bucobo, Lionel S D'Souza, Eduardo J Quintero, Demetrios J Tzimas, Jonathan M Buscaglia
Placement of a pancreatic duct (PD) stent for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP)1-3 often necessitates a second procedure for stent removal, generally within 2-4 weeks to avoid stent occlusion or injury to the duct.4 These procedures are associated with increased costs and may result in procedure-related complications. Stents without internal anchoring flaps were developed to allow spontaneous migration into the duodenum,5 thus obviating the need for a repeat procedure...
June 20, 2019: Clinical Gastroenterology and Hepatology
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