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https://www.readbyqxmd.com/read/28210709/clinical-outcomes-of-eus-guided-drainage-of-debris-containing-pancreatic-pseudocysts-a-large-multicenter-study
#1
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Steven A Edmundowicz, John M DeWitt, Mouen A Khashab, Andrew Y Wang, Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo, Mihir S Wagh, Peter V Draganov, Tyler Stevens, John J Vargo, Harshit S Khara, David L Diehl, Rajesh N Keswani, Srinadh Komanduri, Patrick S Yachimski, Anoop Prabhu, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Petros Benias, David L Carr-Locke, Christopher J DiMaio
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28161287/issue-highlights
#2
Jonathan M Buscaglia
No abstract text is available yet for this article.
February 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28151650/molecular-dynamics-simulations-of-membrane-bound-stim1-to-investigate-conformational-changes-during-stim1-activation-upon-calciumrelease
#3
Sreya Mukherjee, Aleksandra Karolak, Marjolaine Debant, Paul Buscaglia, Yves Renaudineau, Olivier Mignen, Wayne Charles Guida, Wesley H Brooks
Calcium is involved in important intracellular processes, such as intracellular signaling from cell membrane receptors to the nucleus. Typically calcium levels are kept at less than 100 nM in the nucleus and cytosol but some calcium is stored in the endoplasmic reticulum (ER) lumen for rapid release to activate intracellular calcium-dependent functions. Stromal Interacting Molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER's calcium level, especially when there is a sudden release of stored calcium from the ER...
February 2, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28114688/lumen-apposing-covered-self-expandable-metal-stents-for-short-benign-gastrointestinal-strictures-a-multicenter-study
#4
Dennis Yang, Jose M Nieto, Ali Siddiqui, Brian P Riff, Christopher J DiMaio, Satish Nagula, Amr M Ismail, Saowanee Ngamreungphong, Mouen A Khashab, Mihir S Wagh, Demetrios Tzimas, Jonathan M Buscaglia, Daniel S Strand, Andrew Y Wang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
Background and study aim Use of the fully covered self-expandable metal stent (SEMS) for benign luminal gastrointestinal (GI) stricture (BLGS) has been limited by the migration rate. The role of the lumen-apposing metal stent (LAMS) for BLGS is not well defined. We assessed the safety, feasibility, and efficacy of LAMS for the treatment of BLGS.  Patients and methods This was an observational, open-label, retrospective, single-arm, multicenter consecutive case series of patients undergoing LAMS placement for BLGS...
January 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/28089065/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#5
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28069113/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#6
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
February 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28054339/a-set-of-handwriting-features-for-use-in-automated-writer-identification
#7
John J Miller, Robert Bradley Patterson, Donald T Gantz, Christopher P Saunders, Mark A Walch, JoAnn Buscaglia
A writer's biometric identity can be characterized through the distribution of physical feature measurements ("writer's profile"); a graph-based system that facilitates the quantification of these features is described. To accomplish this quantification, handwriting is segmented into basic graphical forms ("graphemes"), which are "skeletonized" to yield the graphical topology of the handwritten segment. The graph-based matching algorithm compares the graphemes first by their graphical topology and then by their geometric features...
January 5, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27984073/host-epac1-is-required-for-camp-mediated-invasion-by-trypanosoma-cruzi
#8
Daniel Musikant, Gabriel Ferri, Ignacio M Durante, Carlos A Buscaglia, Daniel L Altschuler, Martin M Edreira
Mechanistic details of the modulation by cAMP of Trypanosoma cruzi host cell invasion remain ill-defined. Here we report that activation of host's Epac1 stimulated invasion, whereas specific pharmacological inhibition or maneuvers that alter Epac1 subcellular localization significantly reduced invasion. Furthermore, while specific activation of host cell PKA showed no effect, its inhibition resulted in an increased invasion, revealing a crosstalk between the PKA and Epac signaling pathways during the process of invasion...
January 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/27966542/epilepsy-causing-sequence-variations-in-sik1-disrupt-synaptic-activity-response-gene-expression-and-affect-neuronal-morphology
#9
Christoph Pröschel, Jeanne N Hansen, Adil Ali, Emily Tuttle, Michelle Lacagnina, Georgia Buscaglia, Marc W Halterman, Alex R Paciorkowski
SIK1 syndrome is a newly described developmental epilepsy disorder caused by heterozygous mutations in the salt-inducible kinase SIK1. To better understand the pathophysiology of SIK1 syndrome, we studied the effects of SIK1 pathogenic sequence variations in human neurons. Primary human fetal cortical neurons were transfected with a lentiviral vector to overexpress wild-type and mutant SIK1 protein. We evaluated the transcriptional activity of known downstream gene targets in neurons expressing mutant SIK1 compared with wild type...
February 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27843019/the-trypanosoma-cruzi-surface-a-nanoscale-patchwork-quilt
#10
REVIEW
Juan Mucci, Andrés B Lantos, Carlos A Buscaglia, María Susana Leguizamón, Oscar Campetella
The Trypanosoma cruzi trypomastigote membrane provides a major protective role against mammalian host-derived defense mechanisms while allowing the parasite to interact with different cell types and trigger pathogenesis. This surface has been historically appreciated as a rather unstructured 'coat', mainly consisting of a continuous layer of glycolipids and heavily O-glycosylated mucins, occasionally intercalated with different developmentally regulated molecules displaying adhesive and/or enzymatic properties...
February 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/27714511/interventional-eus-using-a-flexible-19-gauge-needle-an-international-multicenter-experience-in-162-patients
#11
Vivek Kumbhari, Irene Peñas, Alan H Tieu, Carlos De la Serna-Higuera, Manie Juneja, Fuad Maufa, Saowanee Ngamruengphong, Mohamad H El-Zein, Nadim Haddad, Sandeep Krishnan, Susana Gonzalez, Peter V Renny, Payal Saxena, Linda Howard, Christopher J DiMaio, Jonathan M Buscaglia, Manuel Perez-Miranda, Mouen A Khashab
BACKGROUND AND AIMS: To facilitate access for interventional EUS, flexible (nitinol) 19-G needles have been introduced to permit needle puncture even when the echoendoscope is in an angulated position, such as in the second part of the duodenum. The aims of the study were to evaluate the performance of a flexible 19-G needle during interventional EUS procedures and compare outcomes when the echoendoscope was in the straight versus angulated position. METHODS: A retrospective review was undertaken of 162 consecutive patients that underwent a variety of interventional EUS procedures with a flexible 19-G needle across five centers...
December 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27693206/randomized-evidence-for-reduction-of-perioperative-mortality-an-updated-consensus-process
#12
Giovanni Landoni, Antonio Pisano, Vladimir Lomivorotov, Gabriele Alvaro, Ludhmila Hajjar, Gianluca Paternoster, Caetano Nigro Neto, Nicola Latronico, Evgeny Fominskiy, Laura Pasin, Gabriele Finco, Rosetta Lobreglio, Maria Luisa Azzolini, Giuseppe Buscaglia, Alberto Castella, Marco Comis, Adele Conte, Massimiliano Conte, Francesco Corradi, Erika Dal Checco, Giovanni De Vuono, Marco Ganzaroli, Eugenio Garofalo, Gordana Gazivoda, Rosalba Lembo, Daniele Marianello, Martina Baiardo Redaelli, Fabrizio Monaco, Valentina Tarzia, Marta Mucchetti, Alessandro Belletti, Paolo Mura, Mario Musu, Giovanni Pala, Massimiliano Paltenghi, Vadim Pasyuga, Desiderio Piras, Claudio Riefolo, Agostino Roasio, Laura Ruggeri, Francesco Santini, Andrea Székely, Luigi Verniero, Antonella Vezzani, Alberto Zangrillo, Rinaldo Bellomo
OBJECTIVE: Of the 230 million patients undergoing major surgical procedures every year, more than 1 million will die within 30 days. Thus, any nonsurgical interventions that help reduce perioperative mortality might save thousands of lives. The authors have updated a previous consensus process to identify all the nonsurgical interventions, supported by randomized evidence, that may help reduce perioperative mortality. DESIGN AND SETTING: A web-based international consensus conference...
August 2, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27639210/microscopical-characterization-of-known-postmortem-root-bands-using-light-and-scanning-electron-microscopy
#13
Jack Hietpas, JoAnn Buscaglia, Adam H Richard, Stephen Shaw, Hilda S Castillo, Joseph Donfack
A postmortem root band (PMRB) is a distinct microscopic feature that is postulated to occur in hair remaining in the follicle during the postmortem interval [1] (Petraco et al., 1998). The scientific validity of this premise has been highlighted in two recent high-profile criminal cases involving PMRBs [2,3] (State of Florida v. Casey Marie Anthony, 2008; People v. Kogut, 2005). To better understand the fundamental aspects of postmortem root banding, the microscopical properties of known PMRBs(1) were characterized by light microscopy, and scanning electron microscope (SEM) imaging of microtomed sections of hairs showing root banding...
October 2016: Forensic Science International
https://www.readbyqxmd.com/read/27629703/trim9-mediates-netrin-1-induced-neuronal-morphogenesis-in-the-developing-and-adult-hippocampus
#14
Jayne Aiken, Georgia Buscaglia
No abstract text is available yet for this article.
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27520399/issue-highlights
#15
Jonathan M Buscaglia
No abstract text is available yet for this article.
October 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27477511/nrf2-promotes-tumor-maintenance-by-modulating-mrna-translation-in-pancreatic-cancer
#16
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Youngkyu Park, Keith Rivera, Wilhelm Palm, John Wilson, Vineet Sangar, Yuan Hao, Daniel Öhlund, Kevin Wright, Dea Filippini, Eun Jung Lee, Brandon Da Silva, Christina Schoepfer, John Erby Wilkinson, Jonathan M Buscaglia, Gina M DeNicola, Herve Tiriac, Molly Hammell, Howard C Crawford, Edward E Schmidt, Craig B Thompson, Darryl J Pappin, Nahum Sonenberg, David A Tuveson
Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate pancreatic and lung cancer initiation. Here, we show that NRF2 is necessary to maintain pancreatic cancer proliferation by regulating mRNA translation. Specifically, loss of NRF2 led to defects in autocrine epidermal growth factor receptor (EGFR) signaling and oxidation of specific translational regulatory proteins, resulting in impaired cap-dependent and cap-independent mRNA translation in pancreatic cancer cells...
August 11, 2016: Cell
https://www.readbyqxmd.com/read/27349928/impact-and-outcomes-of-research-sponsored-by-the-american-society-for-gastrointestinal-endoscopy
#17
Mohammad F Madhoun, Gregory A Cote, Sushil K Ahlawat, Nuzhat A Ahmad, Jonathan M Buscaglia, Audrey H Calderwood, Seth Crockett, Dayna S Early, Ferga C Gleeson, Suryakanth R Gurudu, Thomas F Imperiale, Julia J Liu, Patrick Mosler, Rahul Pannala, Patrick R Pfau, Joseph Romagnuolo, Jewel Samadder, Amrita Sethi, Amandeep K Shergill, Eun J Shin, Field Willingham, Jason A Dominitz
BACKGROUND AND AIMS: Since 1985, the American Society for Gastrointestinal Endoscopy (ASGE) has awarded grants for endoscopic-related research. The goals of this study were to examine trends in ASGE grant funding and to assess productivity of previous recipients of the ASGE grant awards. METHODS: This was a retrospective cohort analysis of all research grants awarded by the ASGE through 2009. Measures of academic productivity and self-assessment of the ASGE awards' impact on the recipients' careers were defined by using publicly available resources (eg, National Library of Medicine-PubMed) and administration of an electronic survey to award recipients...
September 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27297851/a-randomized-controlled-trial-of-levosimendan-to-reduce-mortality-in-high-risk-cardiac-surgery-patients-cheetah-rationale-and-design
#18
Alberto Zangrillo, Gabriele Alvaro, Antonio Pisano, Fabio Guarracino, Rosetta Lobreglio, Nikola Bradic, Rosalba Lembo, Stefano Gianni, Maria Grazia Calabrò, Valery Likhvantsev, Evgeny Grigoryev, Giuseppe Buscaglia, Giovanni Pala, Elisabetta Auci, Bruno Amantea, Fabrizio Monaco, Giovanni De Vuono, Antonio Corcione, Nicola Galdieri, Claudia Cariello, Tiziana Bove, Evgeny Fominskiy, Stefano Auriemma, Massimo Baiocchi, Alessandro Bianchi, Mario Frontini, Gianluca Paternoster, Fabio Sangalli, Chew-Yin Wang, Maria Chiara Zucchetti, Giuseppe Biondi-Zoccai, Marco Gemma, Michael J Lipinski, Vladimir V Lomivorotov, Giovanni Landoni
OBJECTIVE: Patients undergoing cardiac surgery are at risk of perioperative low cardiac output syndrome due to postoperative myocardial dysfunction. Myocardial dysfunction in patients undergoing cardiac surgery is a potential indication for the use of levosimendan, a calcium sensitizer with 3 beneficial cardiovascular effects (inotropic, vasodilatory, and anti-inflammatory), which appears effective in improving clinically relevant outcomes. DESIGN: Double-blind, placebo-controlled, multicenter randomized trial...
July 2016: American Heart Journal
https://www.readbyqxmd.com/read/27294185/data-on-the-interexaminer-variation-of-minutia-markup-on-latent-fingerprints
#19
Bradford T Ulery, R Austin Hicklin, Maria Antonia Roberts, JoAnn Buscaglia
The data in this article supports the research paper entitled "Interexaminer variation of minutia markup on latent fingerprints" [1]. The data in this article describes the variability in minutia markup during both analysis of the latents and comparison between latents and exemplars. The data was collected in the "White Box Latent Print Examiner Study," in which each of 170 volunteer latent print examiners provided detailed markup documenting their examinations of latent-exemplar pairs of prints randomly assigned from a pool of 320 pairs...
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27193921/quantitative-real-time-detection-of-carcinoembryonic-antigen-cea-from-pancreatic-cyst-fluid-using-3-d-surface-molecular-imprinting
#20
Yingjie Yu, Qi Zhang, Jonathan Buscaglia, Chung-Chueh Chang, Ying Liu, Zhenhua Yang, Yichen Guo, Yantian Wang, Kalle Levon, Miriam Rafailovich
In this study, a sensitive, yet robust, biosensing system with real-time electrochemical readout was developed. The biosensor system was applied to the detection of carcinoembryonic antigen (CEA), which is a common marker for many cancers such as pancreatic, breast, and colon cancer. Real time detection of CEA during a medical procedure can be used to make critical decisions regarding further surgical intervention. CEA was templated on gold surface (RMS roughness ∼3-4 nm) coated with a hydrophilic self-assembled monolayer (SAM) on the working electrode of an open circuit potentiometric network...
July 21, 2016: Analyst
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