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https://www.readbyqxmd.com/read/29742296/timing-and-appearance-of-postmortem-root-banding-in-nonhuman-mammals
#1
Adam H Richard, Jack Hietpas, JoAnn Buscaglia, Keith L Monson
A study was undertaken using nonhuman mammal specimens to better understand environmental influences on postmortem hair root band (PMRB) formation and to see whether PMRBs would occur in nonhuman mammal hairs in a similar fashion to human hairs. Carcasses from surrounding roadways were the primary source of specimens for this study, augmented by donated deceased domestic pets. Sections of pelt from each specimen were placed in controlled environmental conditions while the remainder of the carcass was left in a secure outdoor setting...
May 9, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29623911/a-multicenter-evaluation-of-a-new-eus-core-biopsy-needle-experience-in-200-patients
#2
Douglas G Adler, V Raman Muthusamy, Dean S Ehrlich, Gulshan Parasher, Nirav C Thosani, Ann Chen, Jonathan M Buscaglia, Anoop Appannagari, Eduardo Quintero, Harry Aslanian, Linda Jo Taylor, Ali Siddiqui
Background and Objectives: We present a multicenter study of a new endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle (Acquire, Boston Scientific, Natick, MA). The aim of the study was to analyze the needle's clinical performance when sampling solid lesions and to assess the safety of this device. Methods: We performed a multicenter retrospective study of patients undergoing EUS-FNB during July 1-November 15, 2016. Results: Two hundred patients (121 males and 79 females) underwent EUS-FNB of solid lesions with the Acquire needle...
April 4, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29573782/asge-guideline-for-infection-control-during-gi-endoscopy
#3
Audrey H Calderwood, Lukejohn W Day, V Raman Muthusamy, James Collins, Ralph David Hambrick, Andrew S Brock, Nalini M Guda, Jonathan M Buscaglia, Bret T Petersen, Navtej S Buttar, Lauren G Khanna, Vladimir M Kushnir, Aparna Repaka, Nicolas A Villa, Glenn M Eisen
No abstract text is available yet for this article.
May 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29570171/factors-associated-with-health-care-utilization-of-recurrent-clostridium-difficile-infection-in-new-york-state
#4
Steven N Mathews, Ryan Lamm, Jie Yang, Jihye Park, Demetrios Tzimas, Jonathan M Buscaglia, Aurora Pryor, Mark Talamini, Dana Telem, Juan C Bucobo
BACKGROUND: The incidence of infection due to Clostridium difficile infection (CDI) and subsequent economic burden are substantial. GOALS: The impact of changing practice patterns on demographics at risk and utilization of health care resources for recurrence of CDI remains unclear. STUDY: A total of 291,163 patients hospitalized for CDI were identified from 1995 to 2014 from the New York SPARCS database. The χ test, the Welch t test, and multivariable logistic regression analysis were performed to evaluate factors related to readmission...
March 21, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29458120/major-role-for-trpv1-and-insp3r-in-par2-elicited-inflammatory-mediator-production-in-differentiated-human-keratinocytes
#5
Olivier Gouin, Killian L'Herondelle, Paul Buscaglia, Christelle Le Gall-Ianotto, Réginald Philippe, Nelig Legoux, Olivier Mignen, Virginie Buhé, Raphael Leschiera, Mehdi Sakka, Nathalie Kerfant, Jean-Luc Carré, Raphaele Le Garrec, Luc Lefeuvre, Nicolas Lebonvallet, Laurent Misery
PAR2 activation in basal keratinocytes stimulates inflammation via the Ca2+ -dependent production of mediators such as IL-1β, TNF-α, and TSLP. In this study, we investigated PAR2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR2-activating peptide SLIGKV promoted Ca2+ store depletion in both undifferentiated human primary keratinocytes and DhPKs. SLIGKV-evoked Ca2+ store depletion did not trigger the store-operated Ca2+ entry (i...
February 17, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29444707/percutaneous-transhepatic-vs-endoscopic-retrograde-biliary-drainage-for-suspected-malignant-hilar-obstruction-study-protocol-for-a-randomized-controlled-trial
#6
Firas Al-Kawas, Harry Aslanian, John Baillie, Filip Banovac, Jonathan M Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A Coté, Peter V Draganov, Kulwinder Dua, Valerie Durkalski, B Joseph Elmunzer, Lydia D Foster, Timothy B Gardner, Brian S Geller, Priya Jamidar, Laith H Jamil, Rajesh N Keswani, Mouen A Khashab, Gabriel D Lang, Ryan Law, David Lichtenstein, Simon K Lo, Sean McCarthy, Silvio Melo, Daniel Mullady, Jose Nieto, J Bayne Selby, Vikesh K Singh, Rebecca L Spitzer, Brian Strife, Paul Tarnaksy, Jason R Taylor, Jeffrey Tokar, Andrew Y Wang, April Williams, Field Willingham, Patrick Yachimski
BACKGROUND: The optimal approach to the drainage of malignant obstruction at the liver hilum remains uncertain. We aim to compare percutaneous transhepatic biliary drainage (PTBD) to endoscopic retrograde cholangiography (ERC) as the first intervention in patients with cholestasis due to suspected malignant hilar obstruction (MHO). METHODS: The INTERCPT trial is a multi-center, comparative effectiveness, randomized, superiority trial of PTBD vs. ERC for decompression of suspected MHO...
February 14, 2018: Trials
https://www.readbyqxmd.com/read/29385143/longitudinal-microbiome-analysis-of-single-donor-fecal-microbiota-transplantation-in-patients-with-recurrent-clostridium-difficile-infection-and-or-ulcerative-colitis
#7
Michael Mintz, Shanawaj Khair, Suman Grewal, Joseph F LaComb, Jiyhe Park, Breana Channer, Ramona Rajapakse, Juan Carlos Bucobo, Jonathan M Buscaglia, Farah Monzur, Anupama Chawla, Jie Yang, Charlie E Robertson, Daniel N Frank, Ellen Li
BACKGROUND: Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitoring microbial composition in the recipient before and after FMT, as compared with their respective donor...
2018: PloS One
https://www.readbyqxmd.com/read/29325707/successful-creation-of-pancreatic-cancer-organoids-by-means-of-eus-guided-fine-needle-biopsy-sampling-for-personalized-cancer-treatment
#8
Herve Tiriac, Juan Carlos Bucobo, Demetrios Tzimas, Suman Grewel, Joseph F Lacomb, Leahana M Rowehl, Satish Nagula, Maoxin Wu, Joseph Kim, Aaron Sasson, Shivakumar Vignesh, Laura Martello, Maria Munoz-Sagastibelza, Jonathan Somma, David A Tuveson, Ellen Li, Jonathan M Buscaglia
BACKGROUND AND AIMS: Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately, most patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) sampling in patients with PDA...
January 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29280518/a-new-tool-to-test-active-ingredient-using-lactic-acid-in-vitro-a-help-to-understand-cellular-mechanism-involved-in-stinging-test-an-example-using-a-bacterial-polysaccharide-fucogel-%C3%A2
#9
Mehdi Sakka, Raphael Leschiera, Christelle Le Gall-Ianotto, Olivier Gouin, Killian L'herondelle, Paul Buscaglia, Olivier Mignen, Jean-Luc Philbé, Thibaut Saguet, Jean-Luc Carré, Laurent Misery, Nicolas Lebonvallet
The stinging test is an in vivo protocol that evaluates sensitive skin using lactic acid (LA). A soothing sensation of cosmetics or ingredients can be also appreciated through a decrease in stinging score. To predict the soothing sensation of a product before in vivo testing, we developed a model based on an LA test and substance P (SP) release using a co-culture of human keratinocytes and NGF-differentiated PC12 cells. A bacterial fucose-rich polysaccharide present in Fucogel® was evaluated as the soothing molecule in the in vivo stinging test and our in vitro model...
March 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29245220/case-report-of-intestinal-non-rotation-heterotaxy-and-polysplenia-in-a-patient-with-pancreatic-cancer
#10
Spyridon Pagkratis, Sara Kryeziu, Miranda Lin, Samah Hoque, Juan Carlos Bucobo, Jonathan M Buscaglia, Georgios V Georgakis, Aaron R Sasson, Joseph Kim
RATIONALE: Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly complex. This case report demonstrates successful pancreatic cancer resection despite the patient's complicated anatomy. PATIENT CONCERNS: An 82-year-old female presented to our institution with complaints of mild right upper quadrant pain radiating to the mid-epigastric region...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29203224/mantle-cell-lymphoma-presenting-as-lymphomatous-polyposis
#11
Galen Leung, Jela Bandovic, Jonathan M Buscaglia
No abstract text is available yet for this article.
December 2, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29199143/digital-single-operator-cholangioscopy-for-difficult-bile-duct-stones-out-with-the-old-in-with-the-new
#12
EDITORIAL
Dennis Yang, Jonathan M Buscaglia
No abstract text is available yet for this article.
June 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29192487/cation-diffusion-and-segregation-at-the-interface-between-samarium-doped-ceria-and-lscf-or-lsfcu-cathodes-investigated-with-x-ray-microspectroscopy
#13
Francesco Giannici, Giovanna Canu, Alessandro Chiara, Marianna Gambino, Chiara Aliotta, Alessandro Longo, Vincenzo Buscaglia, Antonino Martorana
The chemical compatibility between electrolytes and electrodes is an extremely important aspect governing the overall impedance of solid-oxide cells. Because these devices work at elevated temperatures, they are especially prone to cation interdiffusion between the cell components, possibly resulting in secondary insulating phases. In this work, we applied X-ray microspectroscopy to study the interface between a samarium-doped ceria (SDC) electrolyte and lanthanum ferrite cathodes (La0.4 Sr0.6 Fe0.8 Cu0.2 O3 (LSFCu); La0...
December 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29176395/integrated-safety-summary-for-trifluridine-tipiracil-tas-102
#14
Alfredo Falcone, Atsushi Ohtsu, Eric Van Cutsem, Robert J Mayer, Michele Buscaglia, Johanna C Bendell, Scott Kopetz, Paul Bebeau, Takayuki Yoshino
Trifluridine/tipiracil, an oral treatment combining trifluridine (an antineoplastic thymidine-based nucleoside analog) and tipiracil hydrochloride (a thymidine phosphorylase inhibitor), led to significant improvement in overall survival in metastatic colorectal cancer (mCRC) patients refractory to standard therapy in the phase III RECOURSE trial. Here, we report an integrated summary of the safety of trifluridine/tipiracil. The main safety analysis includes integrated data from the RECOURSE and J003 studies (safety data group 2) of patients with refractory mCRC receiving trifluridine/tipiracil at the recommended starting dose: 35 mg/m twice daily for 5 days with 2 days' rest for 2 weeks, followed by a 14-day rest (one cycle)...
January 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29155408/dark-field-differential-dynamic-microscopy-enables-accurate-characterization-of-the-roto-translational-dynamics-of-bacteria-and-colloidal-clusters
#15
Roberto Cerbino, Davide Piotti, Marco Buscaglia, Fabio Giavazzi
Micro- and nanoscale objects with anisotropic shape are key components of a variety of biological systems and inert complex materials, and represent fundamental building blocks of novel self-assembly strategies. The time scale of their thermal motion is set by their translational and rotational diffusion coefficients, whose measurement may become difficult for relatively large particles with small optical contrast. Here we show that dark field differential dynamic microscopy is the ideal tool for probing the roto-translational Brownian motion of anisotropic shaped particles...
January 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29057214/the-%C3%AE-tubulin-gene-tuba1a-in-brain-development-a-key-ingredient-in-the-neuronal-isotype-blend
#16
Jayne Aiken, Georgia Buscaglia, Emily A Bates, Jeffrey K Moore
Microtubules are dynamic cytoskeletal polymers that mediate numerous, essential functions such as axon and dendrite growth and neuron migration throughout brain development. In recent years, sequencing has revealed dominant mutations that disrupt the tubulin protein building blocks of microtubules. These tubulin mutations lead to a spectrum of devastating brain malformations, complex neurological and physical phenotypes, and even fatality. The most common tubulin gene mutated is the α-tubulin gene TUBA1A , which is the most prevalent α-tubulin gene expressed in post-mitotic neurons...
September 2017: Journal of Developmental Biology
https://www.readbyqxmd.com/read/28991925/next-generation-elisa-diagnostic-assay-for-chagas-disease-based-on-the-combination-of-short-peptidic-epitopes
#17
Juan Mucci, Santiago J Carmona, Romina Volcovich, Jaime Altcheh, Estefanía Bracamonte, Jorge D Marco, Morten Nielsen, Carlos A Buscaglia, Fernán Agüero
Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. Accurate diagnosis is essential for the early identification and follow up of vector-borne cases and to prevent transmission of the disease by way of blood transfusions and organ transplantation. Diagnosis is routinely performed using serological methods, some of which require the production of parasite lysates, parasite antigenic fractions or purified recombinant antigens...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28978686/the-trypomastigote-small-surface-antigen-from-trypanosoma-cruzi-improves-treatment-evaluation-and-diagnosis-in-pediatric-chagas-disease
#18
Virginia Balouz, Luciano J Melli, Romina Volcovich, Guillermo Moscatelli, Samanta Moroni, Nicolás González, Griselda Ballering, Margarita Bisio, Andrés E Ciocchini, Carlos A Buscaglia, Jaime Altcheh
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi Assessment of parasitological cure upon treatment with available drugs relies on achieving consistent negative results in conventional parasitological and serological tests, which may take years to assess. Here, we evaluated the use of a recombinant T. cruzi antigen termed trypomastigote small surface antigen (TSSA) as an early serological marker of drug efficacy in T. cruzi -infected children. A cohort of 78 pediatric patients born to T. cruzi -infected mothers was included in this study...
December 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28961244/high-resolution-profiling-of-linear-b-cell-epitopes-from-mucin-associated-surface-proteins-masps-of-trypanosoma-cruzi-during-human-infections
#19
Ignacio M Durante, Pablo E La Spina, Santiago J Carmona, Fernán Agüero, Carlos A Buscaglia
BACKGROUND: The Trypanosoma cruzi genome bears a huge family of genes and pseudogenes coding for Mucin-Associated Surface Proteins (MASPs). MASP molecules display a 'mosaic' structure, with highly conserved flanking regions and a strikingly variable central and mature domain made up of different combinations of a large repertoire of short sequence motifs. MASP molecules are highly expressed in mammal-dwelling stages of T. cruzi and may be involved in parasite-host interactions and/or in diverting the immune response...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28800609/the-trypomastigote-small-surface-antigen-tssa-regulates-trypanosoma-cruzi-infectivity-and-differentiation
#20
María de Los Milagros Cámara, Gaspar E Cánepa, Andrés B Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A Buscaglia
BACKGROUND: TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. TSSA displays substantial sequence identity to members of the TcMUC gene family, which code for the trypomastigote mucins (tGPI-mucins). In addition, TSSA bears sequence polymorphisms among parasite strains; and two TSSA variants expressed as recombinant molecules (termed TSSA-CL and TSSA-Sy) were shown to exhibit contrasting features in their host cell binding and signaling properties...
August 2017: PLoS Neglected Tropical Diseases
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