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https://www.readbyqxmd.com/read/28991925/next-generation-elisa-diagnostic-assay-for-chagas-disease-based-on-the-combination-of-short-peptidic-epitopes
#1
Juan Mucci, Santiago J Carmona, Romina Volcovich, Jaime Altcheh, Estefanía Bracamonte, Jorge D Marco, Morten Nielsen, Carlos A Buscaglia, Fernán Agüero
Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. Accurate diagnosis is essential for the early identification and follow up of vector-borne cases and to prevent transmission of the disease by way of blood transfusions and organ transplantation. Diagnosis is routinely performed using serological methods, some of which require the production of parasite lysates, parasite antigenic fractions or purified recombinant antigens...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28978686/the-trypomastigote-small-surface-antigen-from-trypanosoma-cruzi-improves-treatment-evaluation-and-diagnosis-in-pediatric-chagas-disease
#2
Virginia Balouz, Luciano J Melli, Romina Volcovich, Guillermo Moscatelli, Samanta Moroni, Nicolás González, Griselda Ballering, Margarita Bisio, Andrés Ciocchini, Carlos A Buscaglia, Jaime Altcheh
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. Assessment of parasitological cure upon treatment with available drugs relies on achieving consistent negative results in conventional parasitological and serological tests, which may take years to assess. Here, we evaluated the use of a recombinant T. cruzi antigen termed TSSA as an early serological marker of drug efficacy in T. cruzi-infected children. A cohort of 78 pediatric patients born to T. cruzi-infected mothers was included in this study...
October 4, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28961244/high-resolution-profiling-of-linear-b-cell-epitopes-from-mucin-associated-surface-proteins-masps-of-trypanosoma-cruzi-during-human-infections
#3
Ignacio M Durante, Pablo E La Spina, Santiago J Carmona, Fernán Agüero, Carlos A Buscaglia
BACKGROUND: The Trypanosoma cruzi genome bears a huge family of genes and pseudogenes coding for Mucin-Associated Surface Proteins (MASPs). MASP molecules display a 'mosaic' structure, with highly conserved flanking regions and a strikingly variable central and mature domain made up of different combinations of a large repertoire of short sequence motifs. MASP molecules are highly expressed in mammal-dwelling stages of T. cruzi and may be involved in parasite-host interactions and/or in diverting the immune response...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28800609/the-trypomastigote-small-surface-antigen-tssa-regulates-trypanosoma-cruzi-infectivity-and-differentiation
#4
María de Los Milagros Cámara, Gaspar E Cánepa, Andrés B Lantos, Virginia Balouz, Hai Yu, Xi Chen, Oscar Campetella, Juan Mucci, Carlos A Buscaglia
BACKGROUND: TSSA (Trypomastigote Small Surface Antigen) is an antigenic, adhesion molecule displayed on the surface of Trypanosoma cruzi trypomastigotes. TSSA displays substantial sequence identity to members of the TcMUC gene family, which code for the trypomastigote mucins (tGPI-mucins). In addition, TSSA bears sequence polymorphisms among parasite strains; and two TSSA variants expressed as recombinant molecules (termed TSSA-CL and TSSA-Sy) were shown to exhibit contrasting features in their host cell binding and signaling properties...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28757253/enhancer-reprogramming-promotes-pancreatic-cancer-metastasis
#5
Jae-Seok Roe, Chang-Il Hwang, Tim D D Somerville, Joseph P Milazzo, Eun Jung Lee, Brandon Da Silva, Laura Maiorino, Hervé Tiriac, C Megan Young, Koji Miyabayashi, Dea Filippini, Brianna Creighton, Richard A Burkhart, Jonathan M Buscaglia, Edward J Kim, Jean L Grem, Audrey J Lazenby, James A Grunkemeyer, Michael A Hollingsworth, Paul M Grandgenett, Mikala Egeblad, Youngkyu Park, David A Tuveson, Christopher R Vakoc
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how transcription and the enhancer landscape become altered during discrete stages of disease progression in a PDA mouse model. This approach revealed that the metastatic transition is accompanied by massive and recurrent alterations in enhancer activity. We implicate the pioneer factor FOXA1 as a driver of enhancer activation in this system, a mechanism that renders PDA cells more invasive and less anchorage-dependent for growth in vitro, as well as more metastatic in vivo...
August 24, 2017: Cell
https://www.readbyqxmd.com/read/28624647/comparison-of-endoscopic-ultrasound-fine-needle-aspiration-and-endoscopic-ultrasound-fine-needle-biopsy-for-solid-lesions-in-a%C3%A2-multicenter-randomized-trial
#6
Satish Nagula, Kamron Pourmand, Harry Aslanian, Juan Carlos Bucobo, Tamas A Gonda, Susana Gonzalez, Adam Goodman, Seth A Gross, Sammy Ho, Christopher J DiMaio, Michelle K Kim, Shireen Pais, John M Poneros, David H Robbins, Felice Schnoll-Sussman, Amrita Sethi, Jonathan M Buscaglia
BACKGROUND & AIMS: Endoscopic ultrasound with fine-needle aspiration (FNA) is the standard of care for tissue sampling of solid lesions adjacent to the gastrointestinal tract. Fine-needle biopsy (FNB) may provide higher diagnostic yield with fewer needle passes. The aim of this study was to assess the difference in diagnostic yield between FNA and FNB. METHODS: This is a multicenter, prospective randomized clinical trial from 6 large tertiary care centers. Patients referred for tissue sampling of solid lesions were randomized to either FNA or FNB of the target lesion...
June 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28602494/an-enlarged-painful-scrotum
#7
Jeries Paolo Zawaideh, Luca Berardi, Michele Buscaglia, Lorenzo Egildo Derchi
No abstract text is available yet for this article.
June 8, 2017: Surgery
https://www.readbyqxmd.com/read/28516266/constitutive-calcium-entry-and-cancer-updated-views-and-insights
#8
REVIEW
Olivier Mignen, Bruno Constantin, Marie Potier-Cartereau, Aubin Penna, Mathieu Gautier, Maxime Guéguinou, Yves Renaudineau, Kenji F Shoji, Romain Félix, Elsa Bayet, Paul Buscaglia, Marjolaine Debant, Aurélie Chantôme, Christophe Vandier
Tight control of basal cytosolic Ca(2+) concentration is essential for cell survival and to fine-tune Ca(2+)-dependent cell functions. A way to control this basal cytosolic Ca(2+) concentration is to regulate membrane Ca(2+) channels including store-operated Ca(2+) channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca(2+) channels involved...
July 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28501619/a-label-free-immunoassay-for-flavivirus-detection-by-the-reflective-phantom-interface-technology
#9
Giovanni Tagliabue, Valentina Faoro, Serena Rizzo, Daniele Sblattero, Andrea Saccani, Gabriele Riccio, Tommaso Bellini, Matteo Salina, Marco Buscaglia, Alessandro Marcello
Flaviviruses are widespread and cause clinically relevant arboviral diseases that impact locally and as imported travel-related infections. Direct detection of viraemia is limited, being typically undetectable at onset of symptoms. Therefore, diagnosis is primarily based on serology, which is complicated by high cross-reactivity across different species. The overlapping geographical distribution of the vectors in areas with a weak healthcare system, the increase of international travel and the similarity of symptoms highlight the need for rapid and reliable multi-parametric diagnostic tests in point-of-care formats...
October 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28452234/analytically-diagnosed-intoxication-by-2-methoxphenidine-and-flubromazepam-mimicking-an-ischemic-cerebral-disease
#10
Antonella Valli, Davide Lonati, Carlo Alessandro Locatelli, Eleonora Buscaglia, Marcello Di Tuccio, Pietro Papa
No abstract text is available yet for this article.
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28325368/chagas-disease-diagnostic-applications-present-knowledge-and-future-steps
#11
REVIEW
V Balouz, F Agüero, C A Buscaglia
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating illness of major significance throughout Latin America and an emergent threat to global public health. Being a neglected disease, the vast majority of Chagasic patients have limited access to proper diagnosis and treatment, and there is only a marginal investment into R&D for drug and vaccine development. In this context, identification of novel biomarkers able to transcend the current limits of diagnostic methods surfaces as a main priority in Chagas disease applied research...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28324769/factors-associated-with-latent-fingerprint-exclusion-determinations
#12
Bradford T Ulery, R Austin Hicklin, Maria Antonia Roberts, JoAnn Buscaglia
Exclusion is the determination by a latent print examiner that two friction ridge impressions did not originate from the same source. The concept and terminology of exclusion vary among agencies. Much of the literature on latent print examination focuses on individualization, and much less attention has been paid to exclusion. This experimental study assesses the associations between a variety of factors and exclusion determinations. Although erroneous exclusions are more likely to occur on some images and for some examiners, they were widely distributed among images and examiners...
February 22, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28210709/clinical-outcomes-of-eus-guided-drainage-of-debris-containing-pancreatic-pseudocysts-a-large-multicenter-study
#13
Dennis Yang, Sunil Amin, Susana Gonzalez, Daniel Mullady, Steven A Edmundowicz, John M DeWitt, Mouen A Khashab, Andrew Y Wang, Satish Nagula, Jonathan M Buscaglia, Juan Carlos Bucobo, Mihir S Wagh, Peter V Draganov, Tyler Stevens, John J Vargo, Harshit S Khara, David L Diehl, Rajesh N Keswani, Srinadh Komanduri, Patrick S Yachimski, Anoop Prabhu, Richard S Kwon, Rabindra R Watson, Adam J Goodman, Petros Benias, David L Carr-Locke, Christopher J DiMaio
Background and study aims Data on clinical outcomes of endoscopic drainage of debris-free pseudocysts (PDF) versus pseudocysts containing solid debris (PSD) are very limited. The aims of this study were to compare treatment outcomes between patients with PDF vs. PSD undergoing endoscopic ultrasound (EUS)-guided drainage via transmural stents. Patients and methods Retrospective review of 142 consecutive patients with pseudocysts who underwent EUS-guided transmural drainage (TM) from 2008 to 2014 at 15 academic centers in the United States...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28161287/issue-highlights
#14
Jonathan M Buscaglia
No abstract text is available yet for this article.
February 1, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28151650/molecular-dynamics-simulations-of-membrane-bound-stim1-to-investigate-conformational-changes-during-stim1-activation-upon-calcium-release
#15
Sreya Mukherjee, Aleksandra Karolak, Marjolaine Debant, Paul Buscaglia, Yves Renaudineau, Olivier Mignen, Wayne C Guida, Wesley H Brooks
Calcium is involved in important intracellular processes, such as intracellular signaling from cell membrane receptors to the nucleus. Typically, calcium levels are kept at less than 100 nM in the nucleus and cytosol, but some calcium is stored in the endoplasmic reticulum (ER) lumen for rapid release to activate intracellular calcium-dependent functions. Stromal interacting molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER's calcium level, especially when there is a sudden release of stored calcium from the ER...
February 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28114688/lumen-apposing-covered-self-expandable-metal-stents-for-short-benign-gastrointestinal-strictures-a-multicenter-study
#16
MULTICENTER STUDY
Dennis Yang, Jose M Nieto, Ali Siddiqui, Brian P Riff, Christopher J DiMaio, Satish Nagula, Amr M Ismail, Saowanee Ngamreungphong, Mouen A Khashab, Mihir S Wagh, Demetrios Tzimas, Jonathan M Buscaglia, Daniel S Strand, Andrew Y Wang, Shailendra S Chauhan, Christopher E Forsmark, Peter V Draganov
Background and study aim Use of the fully covered self-expandable metal stent (SEMS) for benign luminal gastrointestinal (GI) stricture (BLGS) has been limited by the migration rate. The role of the lumen-apposing metal stent (LAMS) for BLGS is not well defined. We assessed the safety, feasibility, and efficacy of LAMS for the treatment of BLGS. Patients and methods This was an observational, open-label, retrospective, single-arm, multicenter consecutive case series of patients undergoing LAMS placement for BLGS...
April 2017: Endoscopy
https://www.readbyqxmd.com/read/28089065/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#17
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
January 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28069113/multisociety-guideline-on-reprocessing-flexible-gi-endoscopes-2016-update
#18
Bret T Petersen, Jonathan Cohen, Ralph David Hambrick, Navtej Buttar, David A Greenwald, Jonathan M Buscaglia, James Collins, Glenn Eisen
No abstract text is available yet for this article.
February 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28054339/a-set-of-handwriting-features-for-use-in-automated-writer-identification
#19
John J Miller, Robert Bradley Patterson, Donald T Gantz, Christopher P Saunders, Mark A Walch, JoAnn Buscaglia
A writer's biometric identity can be characterized through the distribution of physical feature measurements ("writer's profile"); a graph-based system that facilitates the quantification of these features is described. To accomplish this quantification, handwriting is segmented into basic graphical forms ("graphemes"), which are "skeletonized" to yield the graphical topology of the handwritten segment. The graph-based matching algorithm compares the graphemes first by their graphical topology and then by their geometric features...
May 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27984073/host-epac1-is-required-for-camp-mediated-invasion-by-trypanosoma-cruzi
#20
Daniel Musikant, Gabriel Ferri, Ignacio M Durante, Carlos A Buscaglia, Daniel L Altschuler, Martin M Edreira
Mechanistic details of the modulation by cAMP of Trypanosoma cruzi host cell invasion remain ill-defined. Here we report that activation of host's Epac1 stimulated invasion, whereas specific pharmacological inhibition or maneuvers that alter Epac1 subcellular localization significantly reduced invasion. Furthermore, while specific activation of host cell PKA showed no effect, its inhibition resulted in an increased invasion, revealing a crosstalk between the PKA and Epac signaling pathways during the process of invasion...
January 2017: Molecular and Biochemical Parasitology
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