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Coeliac disease rheumatoid arthritis

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https://www.readbyqxmd.com/read/26765074/adverse-event-monitoring-of-the-human-papillomavirus-vaccines-in-scotland
#1
R L Cameron, S Ahmed, K G J Pollock
BACKGROUND: Human papillomavirus (HPV) vaccines are currently utilised globally in national immunisation programmes. While evidence from clinical trials and epidemiological studies suggest that the HPV vaccines are both effective and safe, concerns about the safety of the vaccine and scientifically unproven associations with severe adverse events following immunisation have led to dramatic decreases in vaccine uptake in Japan and acceptance issues in other countries. AIM: In Scotland, we utilised hospital admissions data to assess the impact of the HPV immunisation programme on the incidence of 60 diagnoses between 2004 and 2014 in both girls and boys; with boys acting as a comparator group...
April 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/26641498/association-of-extrahepatic-manifestations-with-autoimmune-hepatitis
#2
Guan Wee Wong, Michael A Heneghan
For many patients with autoimmune hepatitis (AIH), the presence of extrahepatic features is well recognised both at the time of presentation and during long-term follow-up. Concomitant 'autoimmune disorders' have been described in 20-50% of patients with AIH, both in adults and children. Indeed, the presence of these associated phenomena has been incorporated into both the original and revised International AIH group scoring systems as an aid to codifying the diagnosis. In acute index presentations, non-specific joint pains sometimes flitting in nature have been reported in 10-60% of patients, and while joint swelling is uncommon, rheumatoid arthritis and mixed connective tissue disease have been reported in 2-4% of patients with AIH...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/26546613/functional-implications-of-disease-specific-variants-in-loci-jointly-associated-with-coeliac-disease-and-rheumatoid-arthritis
#3
Javier Gutierrez-Achury, Maria Magdalena Zorro, Isis Ricaño-Ponce, Daria V Zhernakova, Dorothée Diogo, Soumya Raychaudhuri, Lude Franke, Gosia Trynka, Cisca Wijmenga, Alexandra Zhernakova
Hundreds of genomic loci have been associated with a significant number of immune-mediated diseases, and a large proportion of these associated loci are shared among traits. Both the molecular mechanisms by which these loci confer disease susceptibility and the extent to which shared loci are implicated in a common pathogenesis are unknown. We therefore sought to dissect the functional components at loci shared between two autoimmune diseases: coeliac disease (CeD) and rheumatoid arthritis (RA). We used a cohort of 12 381 CeD cases and 7827 controls, and another cohort of 13 819 RA cases and 12 897 controls, all genotyped with the Immunochip platform...
January 1, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/26457726/recent-insight-in-the-pathophysiology-of-coeliac-disease-relevance-to-rheumatoid-arthritis
#4
REVIEW
Frits Koning
Coeliac disease (CD) is a T cell mediated inflammatory disorder of the small intestine that affects approximately 1% of the population (1, 2). CD is triggered by gluten ingestion, proteins found in wheat, barley and rye. CD4(+) T cells specific for post-translationally modified gluten peptides bound to the disease-predisposing HLA-DQ2 or HLADQ8 molecules are typically found in patients with CD, explaining the strong association between these HLA-alleles and the occurrence of CD (1, 2). In addition, antibodies specific for modified gluten are also present in patients with CD, implying a role for B to T cell presentation (1)...
July 2015: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/25986717/coeliac-disease-and-rheumatoid-arthritis-similar-mechanisms-different-antigens
#5
REVIEW
Frits Koning, Ranjeny Thomas, Jamie Rossjohn, Rene E Toes
Rheumatoid arthritis (RA) and coeliac disease are inflammatory diseases that both have a strong association with class II HLAs: individuals carrying HLA-DQ2.5 and/or HLA-DQ8 alleles have an increased risk of developing coeliac disease, whereas those carrying HLA-DR shared epitope alleles exhibit an increased risk of developing RA. Although the molecular basis of the association with specific HLA molecules in RA remains poorly defined, an immune response against post-translationally modified protein antigens is a hallmark of each disease...
August 2015: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/25966632/association-analysis-of-copy-numbers-of-fc-gamma-receptor-genes-for-rheumatoid-arthritis-and-other-immune-mediated-phenotypes
#6
Lude Franke, Hanane el Bannoudi, Diahann T S L Jansen, Klaas Kok, Gosia Trynka, Dorothee Diogo, Morris Swertz, Karin Fransen, Rachel Knevel, Javier Gutierrez-Achury, Lisbeth Ärlestig, Jeffrey D Greenberg, Joel Kremer, Dimitrios A Pappas, Alexandros Kanterakis, Rinse K Weersma, Annette H M van der Helm-van Mil, Viktor Guryev, Solbritt Rantapää-Dahlqvist, Peter K Gregersen, Robert M Plenge, Cisca Wijmenga, Tom W-J Huizinga, Andreea Ioan-Facsinay, Rene E M Toes, Alexandra Zhernakova
Segmental duplications (SDs) comprise about 5% of the human genome and are enriched for immune genes. SD loci often show copy numbers variations (CNV), which are difficult to tag with genotyping methods. CNV in the Fcγ receptor region (FCGR) has been suggested to be associated with rheumatic diseases. The objective of this study was to delineate association of FCGR-CNV with rheumatoid arthritis (RA), coeliac disease and Inflammatory bowel disease incidence. We developed a method to accurately quantify CNV in SD loci based on the intensity values from the Immunochip platform and applied it to the FCGR locus...
February 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/25416067/does-the-microbiota-play-a-role-in-the-pathogenesis-of-autoimmune-diseases
#7
REVIEW
Mairi H McLean, Dario Dieguez, Lindsey M Miller, Howard A Young
The microbiota of the human metaorganism is not a mere bystander. These microbes have coevolved with us and are pivotal to normal development and homoeostasis. Dysbiosis of the GI microbiota is associated with many disease susceptibilities, including obesity, malignancy, liver disease and GI pathology such as IBD. It is clear that there is direct and indirect crosstalk between this microbial community and host immune response. However, the precise mechanism of this microbial influence in disease pathogenesis remains elusive and is now a major research focus...
February 2015: Gut
https://www.readbyqxmd.com/read/25185856/a-case-of-autoimmune-urticaria-accompanying-autoimmune-polyglandular-syndrome-type-iii-associated-with-hashimoto-s-disease-type-1-diabetes-mellitus-and-vitiligo
#8
Jacek Kasznicki, Józef Drzewoski
We present a case of autoimmune polyglandular syndrome type III (APS III) associated with Hashimoto's disease, type 1 diabetes mellitus, vitiligo and autoimmune urticaria. This rare genetic disorder occurs with unknown frequency in the Polish population. It is characterised by endocrine tissue destruction resulting in the malfunction of multiple organs.Several cases of APS III associated with organ-specific autoimmune diseases such as coeliac disease, hypogonadism and myasthenia gravis, as well as organ-nonspecific or systemic autoimmune diseases such as sarcoidosis, Sjögren syndrome, and rheumatoid arthritis have been described...
2014: Endokrynologia Polska
https://www.readbyqxmd.com/read/25121969/initro-tyr-prediction-of-nitrotyrosine-sites-in-proteins-with-general-pseudo-amino-acid-composition
#9
Yan Xu, Xin Wen, Li-Shu Wen, Ling-Yun Wu, Nai-Yang Deng, Kuo-Chen Chou
Nitrotyrosine is one of the post-translational modifications (PTMs) in proteins that occurs when their tyrosine residue is nitrated. Compared with healthy people, a remarkably increased level of nitrotyrosine is detected in those suffering from rheumatoid arthritis, septic shock, and coeliac disease. Given an uncharacterized protein sequence that contains many tyrosine residues, which one of them can be nitrated and which one cannot? This is a challenging problem, not only directly related to in-depth understanding the PTM's mechanism but also to the nitrotyrosine-based drug development...
2014: PloS One
https://www.readbyqxmd.com/read/24981042/helminth-therapy-or-elimination-epidemiological-immunological-and-clinical-considerations
#10
REVIEW
Linda J Wammes, Harriet Mpairwe, Alison M Elliott, Maria Yazdanbakhsh
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in affluent countries, the deliberate infection of patients with worms is being explored as a possible treatment for inflammatory diseases. Several clinical trials are currently registered, for example, to assess the safety or efficacy of Trichuris suis ova in allergies, inflammatory bowel diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, and autism, and the Necator americanus larvae for allergic rhinitis, asthma, coeliac disease, and multiple sclerosis...
November 2014: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/24936253/12q24-locus-association-with-type-1-diabetes-sh2b3-or-atxn2
#11
REVIEW
Georg Auburger, Suzana Gispert, Suna Lahut, Ozgür Omür, Ewa Damrath, Melanie Heck, Nazlı Başak
Genetic linkage analyses, genome-wide association studies of single nucleotide polymorphisms, copy number variation surveys, and mutation screenings found the human chromosomal 12q24 locus, with the genes SH2B3 and ATXN2 in its core, to be associated with an exceptionally wide spectrum of disease susceptibilities. Hematopoietic traits of red and white blood cells (like erythrocytosis and myeloproliferative disease), autoimmune disorders (like type 1 diabetes, coeliac disease, juvenile idiopathic arthritis, rheumatoid arthritis, thrombotic antiphospholipid syndrome, lupus erythematosus, multiple sclerosis, hypothyroidism and vitiligo), also vascular pathology (like kidney glomerular filtration rate deficits, serum urate levels, plasma beta-2-microglobulin levels, retinal microcirculation problems, diastolic and systolic blood pressure and hypertension, cardiovascular infarction), furthermore obesity, neurodegenerative conditions (like the polyglutamine-expansion disorder spinocerebellar ataxia type 2, Parkinson's disease, the motor-neuron disease amyotrophic lateral sclerosis, and progressive supranuclear palsy), and finally longevity were reported...
June 15, 2014: World Journal of Diabetes
https://www.readbyqxmd.com/read/24903731/thyroid-associated-orbitopathy-is-linked-to-gastrointestinal-autoimmunity
#12
K A Ponto, D Schuppan, I Zwiener, H Binder, A Mirshahi, T Diana, S Pitz, N Pfeiffer, G J Kahaly
Common autoimmune disorders tend to co-exist in the same subjects and cluster in families. The objective of this study was to determine the prevalence of autoimmune co-morbidity in patients with autoimmune thyroid disease (AITD) with and without thyroid-associated orbitopathy (TAO). This was a cross-sectional study conducted at an academic tertiary referral centre. Of 1310 patients with AITD [n = 777 or 59% with Graves' disease (GD) and n = 533, 41% with Hashimoto's thyroiditis (HT)] followed at a specialized joint thyroid-eye out-patient clinic, 176 (13·4%) had an adult type of the autoimmune polyglandular syndrome, 129 (9·8%) type 1 diabetes, 111 (8·5%) coeliac disease, 60 (4·6%) type A autoimmune gastritis, 57 (4·4%) vitiligo and 25 (1·9%) Addison's disease...
October 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24512514/a-review-of-the-current-literature-and-a-guide-to-the-early-diagnosis-of-autoimmune-disorders-associated-with-neuromyelitis-optica
#13
REVIEW
Anand Iyer, Liene Elsone, Richard Appleton, Anu Jacob
Neuromyelitis optica (NMO) is an immune-mediated neurological disorder characterised by recurrent episodes of optic neuritis and longitudinally extensive transverse myelitis. A serum biomarker, aquaporin-4 IgG, the autoantibody against aquaporin-4 water channel, has been specifically associated with NMO and has assisted early recognition and prediction of relapses. Less commonly, a monophasic course, associated with antibodies to myelin oligodendrocyte glycoprotein has been reported. Specific diagnostic criteria have been defined; however, some cases that do not fulfil these criteria (but are nevertheless associated with aquaporin-4 IgG) are classified as NMO spectrum disorder and follow the same relapsing course...
May 2014: Autoimmunity
https://www.readbyqxmd.com/read/24451233/plummer-vinson-syndrome-with-pectus-carinatum-mitral-valve-prolapsus-and-exotropia-in-an-18-year-old-boy
#14
Cem Sahin, Burak Ozseker, Ibrahim Rencuzogullari, Arife Zeybek
The Plummer-Vinson syndrome is a clinical syndrome characterised by dysphagia, web or webs in upper oesophagus and iron-deficiency anaemia. The syndrome is often seen in women of age 40-70 years and rarely in adolescents. Plummer-Vinson syndrome might be associated with malignancy, myeloproliferative disorder and autoimmune diseases including coeliac disease, rheumatoid arthritis and Sjögren syndrome. However, according to our literature search, there are no reports of such case associated with thorax deformity, cardiac pathology and ocular findings...
2014: BMJ Case Reports
https://www.readbyqxmd.com/read/23959365/clinical-implications-of-shared-genetics-and-pathogenesis-in-autoimmune-diseases
#15
REVIEW
Alexandra Zhernakova, Sebo Withoff, Cisca Wijmenga
Many endocrine diseases, including type 1 diabetes mellitus, Graves disease, Addison disease and Hashimoto disease, originate as an autoimmune reaction that affects disease-specific target organs. These autoimmune diseases are characterized by the development of specific autoantibodies and by the presence of autoreactive T cells. They are caused by a complex genetic predisposition that is attributable to multiple genetic variants, each with a moderate-to-low effect size. Most of the genetic variants associated with a particular autoimmune endocrine disease are shared between other systemic and organ-specific autoimmune and inflammatory diseases, such as rheumatoid arthritis, coeliac disease, systemic lupus erythematosus and psoriasis...
November 2013: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/23557090/associations-between-selected-immune-mediated-diseases-and-tuberculosis-record-linkage-studies
#16
Sreeram V Ramagopalan, Raph Goldacre, Andrew Skingsley, Chris Conlon, Michael J Goldacre
BACKGROUND: Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS: We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (the Oxford Record Linkage Study (ORLS)) for a region of southern England in an earlier period. Rate ratios for TB were determined, comparing immune-mediated disease cohorts with comparison cohorts...
2013: BMC Medicine
https://www.readbyqxmd.com/read/23511932/risk-estimation-of-disorders-associated-with-coeliac-disease-a-16-year-danish-nationwide-follow-up-study-based-on-hospital-discharge-data-implications-for-screening
#17
H T Sørensen, K Fonager
We studied the association between coeliac disease and other diseases in a cohort of 896 persons who were registered in the Danish National Registry of Patients during a 16-year period. The registry contains information on all discharge diagnoses from Danish somatic hospitals. The total number of observation years in the cohort was 7144 years. The background population was 5.1 million.The strongest association was found with diabetes mellitus, pancreatic diseases and dermatitis herpetiformis. A weaker association was found with small intestinal cancer, malignant haematological disorders, agammaglobulinaemia and rheumatoid arthritis...
1996: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/23160276/identification-of-a-functional-variant-in-the-kif5a-cyp27b1-mettl1-fam119b-locus-associated-with-multiple-sclerosis
#18
Antonio Alcina, Maria Fedetz, Oscar Fernández, Albert Saiz, Guillermo Izquierdo, Miguel Lucas, Laura Leyva, Juan-Antonio García-León, María Del Mar Abad-Grau, Iraide Alloza, Alfredo Antigüedad, María J Garcia-Barcina, Koen Vandenbroeck, Jezabel Varadé, Belén de la Hera, Rafael Arroyo, Manuel Comabella, Xavier Montalban, Natalia Petit-Marty, Arcadi Navarro, David Otaegui, Javier Olascoaga, Yolanda Blanco, Elena Urcelay, Fuencisla Matesanz
BACKGROUND AND AIM: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants underlying diseases are still unclear. The authors sought to identify the functional variant of this region associated with MS. METHODS: Tag-single nucleotide polymorphism (SNP) analysis of the associated region encoding 15 genes was performed in 2876 MS patients and 2910 healthy Caucasian controls together with expression regulation analyses...
January 2013: Journal of Medical Genetics
https://www.readbyqxmd.com/read/22408231/increased-risk-of-uveitis-in-coeliac-disease-a-nationwide-cohort-study
#19
Kaziwe Mollazadegan, Maria Kugelberg, Leif Tallstedt, Jonas F Ludvigsson
BACKGROUND: Case reports suggest a potential association between coeliac disease (CD) and uveitis, but larger well-controlled studies are lacking. The aim of this study was therefore to examine the risk of uveitis in patients with biopsy-verified CD. METHODS: Small intestinal biopsy reports performed between July 1969 and February 2008 were collected from all (n=28) pathology departments in Sweden. From these reports, 29,044 patients with CD (equals villous atrophy, Marsh 3) were identified...
June 2012: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/22385519/diabetes-coeliac-disease-multiple-sclerosis-and-chronic-arthritis-in-first-degree-relatives-of-patients-with-juvenile-idiopathic-arthritis
#20
Heini Pohjankoski, Hannu Kautiainen, Kaisu Kotaniemi, Matti Korppi, Anneli Savolainen
AIM: To evaluate the occurrence of autoimmune diseases in first-degree relatives of children with juvenile idiopathic arthritis (JIA) and to compare the figures with published population data. MATERIALS AND METHODS: Families of the 362 children with recently diagnosed JIA admitted to Rheumatism Foundation Hospital, Finland, from 1996 to 2001 were contacted by questionnaires regarding autoimmune diseases in family members. Data were collected on type 1 diabetes, coeliac disease, multiple sclerosis and chronic arthritis, consisting mainly of JIA, rheumatoid arthritis, spondyloarthropathy or psoriatic arthritis...
July 2012: Acta Paediatrica
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