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https://www.readbyqxmd.com/read/29909441/annular-pancreas-in-china-9-years-experience-from-a-single-center
#1
REVIEW
DengLiang Wang, Quan Kang, ShuJun Shi, Wei Hu
To summarize the clinical characteristics, diagnosis, treatment and prognosis among 152 children with annular pancreas (AP). A retrospective review of 152 patients with AP who were treated with surgical repair between January 2009 and August 2017 was performed at our pediatric surgical units. Presenting symptoms, birth weight, radiological findings, associated anomalies, the type of surgery performed were analyzed. (1) 152 patients were identified, out of which 82 were males, and 70 were females; (2) the average birth weight of children with AP was less than that of healthy newborns...
June 16, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29909193/the-inadequate-bladder-template-its-effect-on-outcomes-in-classic-bladder-exstrophy
#2
Heather N Di Carlo, Mahir Maruf, John Jayman, Karl Benz, Mathew Kasprenski, John P Gearhart
INTRODUCTION: Newborns with classic bladder exstrophy (CBE) may present with a bladder template that is inadequate for closure in the neonatal period (figure). In these cases, a delayed primary closure (DPC) is conducted to permit growth of the bladder template. This study reports the surgical and long-term urinary continence outcomes of poor template CBE patients undergoing DPC and compares them to patients who underwent DPC for reasons unrelated to bladder quality (i.e., prematurity, comorbidities, or a late referral)...
May 10, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29909089/safety-of-laparoscopic-surgery-for-benign-diseases-during-pregnancy-a-nationwide-retrospective-cohort-study
#3
Daisuke Shigemi, Shotaro Aso, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
STUDY OBJECTIVE: To compare fetal, maternal, and operative outcomes of laparoscopic surgery versus laparotomy for major benign diseases including appendicitis, cholecystitis, adnexal masses, and uterine myoma during pregnancy. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2). SETTING: The Diagnosis Procedure Combination database, a national inpatient database for acute-care inpatients in Japan. PATIENTS: 6,018 eligible patients underwent abdominal surgery (4,047 laparotomy and 1,971 laparoscopy patients) from July 2010 through March 2016...
June 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908963/nonfunctional-mutant-wrn-protein-leads-to-neurological-deficits-neuronal-stress-microglial-alteration-and-immune-imbalance-in-a-mouse-model-of-werner-syndrome
#4
Chin Wai Hui, Marie-Kim St-Pierre, Jérôme Detuncq, Lucie Aumailley, Marie-Julie Dubois, Vanessa Couture, Daniel Skuk, André Marette, Jacques P Tremblay, Michel Lebel, Marie-Ève Tremblay
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a shorter lifespan. Yet, little is known about the impact of WRN mutations on the central nervous system in both humans and mouse models of WS. In the current study, we have performed a longitudinal behavioral assessment on mice bearing a Wrn helicase deletion. Behavioral tests demonstrated a loss of motor activity and coordination, reduction in perception, increase in repetitive behavior, and deficits in both spatial and social novelty memories in Wrn mutant mice compared to age-matched wild type mice...
June 14, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29908845/lead-exposure-induces-alzheimers-s-disease-ad-like-pathology-and-disturbes-cholesterol-metabolism-in-the-young-rat-brain
#5
Cancan Zhou, Zhenyan Gao, Ju Wang, Meiqin Wu, Shuang Hu, Fei Chen, Junxia Liu, Hui Pan, Chonghuai Yan
Lead exposure has been evidenced as a risk factor for Alzheimer's disease (AD), mainly affecting the ageing. However, the early manifestation and mechanisms of AD-like pathology induced by lead exposure remains to be elucidated. Considering the fact that impaired cholesterol metabolism is associated with many neurodegenerative disorders including AD, in this study we focused on the role of cholesterol metabolism in lead induced premature AD-like pathology. We treated weaning rats with lead at different concentrations for 4 weeks...
June 14, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29908691/pancreatic-enzyme-replacement-therapy-following-surgery-for-pancreatic-cancer-an-exploration-of-patient-self-management
#6
Lisa Dunleavy, Ahmed Al-Mukhtar, Vanessa Halliday
BACKGROUND: For those diagnosed with pancreatic cancer, ill-addressed pancreatic exocrine insufficiency (PEI) following surgery can result in malnutrition related complications that may impact on predict mortality and morbidity. The use of pancreatic enzyme replacement therapy (PERT) is recommended and often demands a degree of patient self-management. Understanding more about how this treatment is managed is fundamental to optimising care. OBJECTIVE: This study aimed to explore patient self-management of PERT following surgery for pancreatic cancer...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908311/longitudinal-study-of-neonatal-brain-tissue-volumes-in-preterm-infants-and-their-ability-to-predict-neurodevelopmental-outcome
#7
REVIEW
L Gui, S Loukas, F Lazeyras, P S Hüppi, D E Meskaldji, C Borradori Tolsa
Premature birth has been associated with poor neurodevelopmental outcomes. However, the relation between such outcomes and brain growth in the neonatal period has not yet been fully elucidated. This study investigates longitudinal brain development between birth and term-equivalent age (TEA) by quantitative imaging in a cohort of premature infants born between 26 and 36 weeks gestational age (GA), to provide insight into the relation of brain growth with later neurodevelopmental outcomes. Longitudinal T2-weighted magnetic resonance images (MRI) of 84 prematurely born infants acquired shortly after birth and TEA were automatically segmented into cortical gray matter (CGM), unmyelinated white matter (UWM), subcortical gray matter (SGM), cerebellum (CB) and cerebrospinal fluid (CSF)...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29907964/evaluation-of-intralesional-injection-of-bleomycin-in-the-treatment-of-plantar-warts-clinical-and-dermoscopic-evaluation
#8
Manal T Barkat, Rasha T A Abdel-Aziz, Mervat S Mohamed
BACKGROUND: Treatment of plantar warts is difficult and requires multiple treatments, and they are more refractory to treatment than common warts. Intralesional bleomycin has been used in the treatment of warts with varying degrees of success. AIM: The aim of the present work is to evaluate the efficacy of intralesional injection of bleomycin in the treatment of plantar warts based on clinical and dermoscopic observations. PATIENTS AND METHODS: Bleomycin (1 mg/ml) was injected intralesionally into the pared plantar wart every 2 weeks for a maximum of four sessions...
June 15, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29907939/feasibility-of-quantitative-ultrasonography-for-the-detection-of-metabolic-bone-disease-in-preterm-infants-systematic-review
#9
REVIEW
Liting Tong, Jaya Sujatha Gopal-Kothandapani, Amaka C Offiah
Metabolic bone disease of prematurity is characterised by disordered bone mineralisation and is therefore an increased fracture risk. Preterm infants are especially at risk due to incomplete in utero bone accretion during the last trimester. Currently, diagnosing metabolic bone disease mainly relies on biochemistry and radiographs. Dual-energy x-ray absorptiometry and quantitative ultrasound (US) are used less frequently. However, biochemical measurements correlate poorly with bone mineralisation and although scoring systems exist for metabolic bone disease, radiographs are subjective and do not detect early features of osteopenia...
June 16, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29907928/trends-in-the-incidence-of-retinopathy-of-prematurity-over-a-10-year-period
#10
Prudence P C Chow, Wilson W K Yip, Mary Ho, Julie Y C Lok, Henry H W Lau, Alvin L Young
AIM: To describe and evaluate the trends in the incidence of retinopathy of prematurity over a 10-year period in a tertiary hospital in Hong Kong. METHODS: A retrospective review was performed on all preterm infants screened and/or treated for retinopathy of prematurity from January 2006 to December 2015 at Prince of Wales Hospital, Hong Kong. Preterm infants with incomplete records or transferred-in from other hospitals/region solely for treatment of ROP were excluded...
June 16, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29907918/farnesyltransferase-inhibitor-and-rapamycin-correct-aberrant-genome-organisation-and-decrease-dna-damage-respectively-in-hutchinson-gilford-progeria-syndrome-fibroblasts
#11
Mehmet U Bikkul, Craig S Clements, Lauren S Godwin, Martin W Goldberg, Ian R Kill, Joanna M Bridger
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal premature ageing disease in children. HGPS is one of several progeroid syndromes caused by mutations in the LMNA gene encoding the nuclear structural proteins lamins A and C. In classic HGPS the mutation G608G leads to the formation of a toxic lamin A protein called progerin. During post-translational processing progerin remains farnesylated owing to the mutation interfering with a step whereby the farnesyl moiety is removed by the enzyme ZMPSTE24...
June 15, 2018: Biogerontology
https://www.readbyqxmd.com/read/29907917/neurologic-consequences-of-preterm-birth
#12
REVIEW
Margie A Ream, Lenora Lehwald
PURPOSE OF REVIEW: Preterm birth is the leading cause of death worldwide in children < 5 years of age; however, technology and advances in medical knowledge are increasing the survival of children born even at the fringes of viability. With increased survival comes increased risk of long-term neurologic impairments. This paper aims to review recent findings related to changes in brain development associated with prematurity and its impact on neurodevelopmental disabilities. RECENT FINDINGS: Advanced imaging techniques, longitudinal follow-up of individuals born extremely preterm into adulthood and improved understanding of risk factors associated with neurologic impairment contribute to recent discoveries...
June 16, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29907817/serum-proteomic-profiling-to-identify-biomarkers-of-premature-carotid-atherosclerosis
#13
Santosh D Bhosale, Robert Moulder, Mikko S Venäläinen, Juhani S Koskinen, Niina Pitkänen, Markus T Juonala, Mika A P Kähönen, Terho J Lehtimäki, Jorma S A Viikari, Laura L Elo, David R Goodlett, Riitta Lahesmaa, Olli T Raitakari
To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N = 43, Age = 30-45 years) were compared with plaque free controls (N = 43) (matched for age, sex, body weight and systolic blood pressure)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#14
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29907315/maternal-risk-factors-and-perinatal-characteristics-of-anorectal-malformations
#15
Anna Svenningsson, Anna Gunnarsdottir, Tomas Wester
PURPOSE: The aim of this study was to assess maternal risk factors and perinatal characteristics of patients with anorectal malformations (ARM) in Sweden. METHODS: Population-based case-control study including all patients with ARM born in Sweden 1973-2014. Patients were identified from the Swedish National Patient Register, and data on possible maternal risk factors and perinatal characteristics were obtained from the Swedish Medical Birth Register. The association between study variables and ARM was analyzed using conditional logistic regression...
April 17, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29907147/health-related-quality-of-life-of-preterm-born-children-at-three-years-in-a-sub-urban-district-in-sri-lanka-a-retrospective-cohort-study
#16
Hemali Jayakody, Upul Senarath, Deepika Attygalle
BACKGROUND: Preterm birth leads to multiple morbidities affecting the health of a child. Lack of information on the health impact of prematurity hinders the possibility of any effective public health interventions in this regard. Our aim was to determine the association between preterm birth and Health-Related Quality of Life (HRQOL) among 3 years old children in the Gampaha district, Sri Lanka. METHODS: A community-based retrospective cohort study was conducted among 790 preterm and term born children who were 03 years old...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29906796/regional-tissue-oxygen-extraction-and-severity-of-anemia-in-very-low-birth-weight-neonates-a-pilot-nirs-analysis
#17
Jonathan P Mintzer, Boriana Parvez, Edmund F La Gamma
OBJECTIVE:  Anemia causes blood flow redistribution and altered tissue metabolic behavior to sustain homeostatic oxygen consumption. We hypothesized that anemia severity would correlate with increased regional fractional tissue oxygen extraction among premature neonates. STUDY DESIGN:  Regional oxygen extraction was calculated using pulse oximetry and near-infrared spectroscopy data among neonates <1,250 g during their first 10 postnatal days. Oxygen extraction was assessed for correlations with raw hematocrit levels and following grouping into hematocrit quartiles...
June 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29906794/development-of-a-hybrid-course-on-wheelchair-service-provision-for-clinicians-in-international-contexts
#18
Yohali Burrola-Mendez, Mary Goldberg, Rachel Gartz, Jon Pearlman
INTRODUCTION: Wheelchair users worldwide are at high risk of developing secondary health conditions and premature death due to inappropriate wheelchair provision by untrained providers. The International Society of Wheelchair Professionals (ISWP) has developed a Hybrid Course based on the World Health Organization's Wheelchair Service Training Package-Basic Level. The Hybrid Course leverages online modules designed for low-bandwidth internet access that reduces the in-person training exposure from five to three and a half days, making it less expensive and more convenient for both trainees and trainers...
2018: PloS One
https://www.readbyqxmd.com/read/29906699/causes-of-mortality-in-early-infantile-epileptic-encephalopathy-a-systematic-review
#19
REVIEW
Graciane Radaelli, Francisco de Souza Santos, Wyllians Vendramini Borelli, Leonardo Pisani, Magda Lahorgue Nunes, Fulvio Alexandre Scorza, Jaderson Costa da Costa
INTRODUCTION: Early infantile epileptic encephalopathy syndrome (EIEE), also known as Ohtahara syndrome, is an age-dependent epileptic encephalopathy syndrome defined by clinical features and electroencephalographic findings. Epileptic disorders with refractory seizures beginning in the neonatal period and/or early infancy have a potential risk of premature mortality, including sudden death. We aimed to identify the causes of death in EIEE and conducted a literature survey of fatal outcomes...
June 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29906650/prophasing-interphase-chromatin-for-assessing-genetic-damages-the-evolution-applications-and-the-future-prospects
#20
REVIEW
Maddaly Ravi, Aswathy S Lal, S Kauser Begum
Premature chromosome condensation (PCC) involves induction of near-chromosome-like morphology to interphase chromatin. Experimental induction of PCC was achieved by somatic cell hybridization (SCH), an approach which evolved into a chemical-induction process. PCC presents most probably the only way in which cytogenetic assessment of damages can be analyzed in special situations such as availability of limited numbers of sample cells and for cells which have lost their ability to divide. Initial experiments on PCC were reported in late 1960s and the technique has evolved into one with wide range of applications owing to its increased efficiency in detecting primary DNA damages...
June 8, 2018: Mutation Research
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