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https://www.readbyqxmd.com/read/27903512/thyroid-hormone-stimulated-increases-in-pgc-1%C3%AE-and-ucp2-promote-life-history-specific-endocrine-changes-and-maintain-a-lipid-based-metabolism
#1
Bridget Martinez, José G Soñanez-Organis, Jose A Godoy-Lugo, Lillian Horin, Daniel E Crocker, Rudy M Ortiz
Thyroid hormones (TH) regulate metabolism, but are typically suppressed during times of stressful physiological conditions, including fasting. Interestingly, prolonged fasting in northern elephant seal pups is associated with reliance on a lipid-based metabolism and increased levels of circulating thyroid hormones that are partially attributed to active secretion as opposed to reduced clearance. This apparent paradox is coupled with complementary increases in cellular TH-mediated activity suggesting that in mammals naturally adapted to prolonged fasting TH are necessary to support metabolism...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27899181/corrigendum-to-short-chain-fatty-acids-induce-ucp2-mediated-autophagy-in-hepatic-cells-biochem-biophys-res-commun-480-2016-461-467
#2
Liliana F Iannucci, Jingfeng Sun, Brijesh K Singh, Jin Zhou, Vincent A Kaddai, Antonia Lanni, Paul M Yen, Rohit A Sinha
No abstract text is available yet for this article.
November 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27875726/the-association-of-uncoupling-protein-2-ucp2-exon-8-insertion-deletion-polymorphism-and-ecg-derived-qrs-duration-a-cross-sectional-study-in-an-australian-rural-population
#3
Yvonne Yin Leng Lee, Yuling Zhou, Herbert F Jelinek, Brett D Hambly, Craig S McLachlan
BACKGROUND: Associations between inherited mitochondrial disease and cardiac conduction have been previously described. However, there are no available studies exploring the mitochondrial uncoupling protein 2 gene (UCP2) insertion/deletion (I/D) polymorphisms interaction on cardiac electrical conduction. Our aim was to determine if ECG-derived QRS duration is associated with UCP2 DD genotype in a cross-sectional Australian aging rural population. METHODS: A retrospective study design utilizing a rural health diabetic screening clinic data-base containing observational data from September 2011 to September 2014...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27864377/mitochondrial-and-redox-abnormalities-in-autism-lymphoblastoid-cells-a-sibling-control-study
#4
Shannon Rose, Sirish C Bennuri, Rebecca Wynne, Stepan Melnyk, S Jill James, Richard E Frye
Autism spectrum disorder (ASD) is associated with physiological abnormalities including abnormal redox and mitochondrial metabolism. Lymphoblastoid cell lines (LCLs) from some children with ASD exhibit increased oxidative stress, decreased glutathione redox capacity, and highly active mitochondria with increased vulnerability to reactive oxygen species (ROS). Because unaffected siblings (Sibs) of individuals with ASD share some redox abnormalities, we sought to determine whether LCLs from Sibs share ASD-associated mitochondrial abnormalities...
November 18, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27863349/trpv1-channels-in-cardiovascular-system-a-double-edged-sword
#5
REVIEW
Puneet Kaur Randhawa, Amteshwar Singh Jaggi
Apart from modulating nociception, there is vital role of TRPV1 channels in modulating atherosclerosis, congestive heart failure, systemic hypertension, pulmonary hypertension, hemorrhagic shock and vascular remodeling. TRPV1 channel activation has shielding effect against the development of atherosclerosis and systemic hypertension. TRPV1 channel activation alleviates the formation of atherosclerotic lesions via increasing the expression of cholesterol efflux regulatory protein, UCP 2 and enhancing autophagy...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27806373/the-genetic-predisposition-score-of-seven-obesity-related-single-nucleotide-polymorphisms-is-associated-with-better-metabolic-outcomes-after-roux-en-y-gastric-bypass
#6
Carolina Ferreira Nicoletti, Marcela A Souza Pinhel, Bruno Affonso Parenti de Oliveira, Julio Sergio Marchini, Wilson Salgado Junior, Wilson Araujo Silva Junior, Carla Barbosa Nonino
BACKGROUND/AIMS: Genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes. This study aimed to estimate the contribution of a genetic predisposition score (GPS) calculated from 7 obesity-related polymorphisms to the improvement of biochemical parameters 1 year after Roux-en-Y gastric bypass (RYGB). METHODS: Obese patients (n = 150; aged 47.2 ± 10.5 years) were enrolled and weight, body mass index (BMI), and biochemical parameters (glycemia and lipid profile) were evaluated preoperatively and 1 year after RYGB...
November 3, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27795298/fabp4-ap2-regulates-macrophage-redox-signaling-and-inflammasome-activation-via-control-of-ucp2
#7
Kaylee A Steen, Hongliang Xu, David A Bernlohr
Obesity-linked metabolic disease is mechanistically associated with the accumulation of proinflammatory macrophages in adipose tissue leading to increased reactive oxygen species (ROS) production and low-grade, chronic inflammation. Previous work has demonstrated that deletion of the adipocyte fatty acid-binding protein (FABP4/aP2) uncouples obesity from inflammation via up-regulation of the uncoupling protein 2 (UCP2). Herein we demonstrate that ablation of FABP4/aP2 regulates systemic redox capacity, reduces cellular protein sulfhydryl oxidation and in particular, oxidation of mitochondrial protein cysteine residues...
October 17, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27794526/association-of-ucp2-866g-a-polymorphism-with-nonalcoholic-fatty-liver-disease-in-patients-from-north-west-of-iran
#8
Fatemeh Mohseni, Safar Farajnia, Mahdieh Abbasalizad Farhangi, Manouchehr Khoshbaten, Mohammad-Asghari Jafarabadi
OBJECTIVE: To investigate the association of uncoupling protein-2 (UCP2) -866G > A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). METHODS: We performed a case-control study with a cohort of 75 patients with NAFLD (of Iranian ethnicity) and 76 healthy individuals of Iranian ethnicity. The UCP2 -866G > A polymorphism (rs659366) was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
October 28, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/27787720/antifibrotic-effect-of-total-flavonoids-of-astmgali-radix-on-dimethylnitrosamine-induced-liver-cirrhosis-in-rats
#9
Yang Cheng, Jing-Yin Mai, Mei-Feng Wang, Gao-Feng Chen, Jian Ping
OBJECTIVE: To study the effect of total flavonoids of Astmgali Radix (TFA) on liver cirrhosis induced with dimethylnitrosamine (DMN) in rats, and the effect on peroxisome proliferator-activated receptor γ (PPARγ), uncoupling protein 2 (UCP2) and farnesoid X receptor (FXR). METHODS: Fifty-three Sprague-Dawley rats were randomly divided into a control group (10 rats) and a DMN group (43 rats). Rats in the DMN group were given DMN for 4 weeks and divided randomly into a model group (14 rats), a low-dosage TFA group (14 rats) and a high-dosage TFA group (15 rats) in the 3rd week...
October 27, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27786441/lipid-loving-ants-molecular-simulations-of-cardiolipin-interactions-and-the-organization-of-the-adenine-nucleotide-translocase-in-model-mitochondrial-membranes
#10
George Hedger, Sarah L Rouse, Jan Domanski, Matthieu Chavent, Heidi Koldsø, Mark S P Sansom
The exchange of ADP and ATP across the inner mitochondrial membrane is a fundamental cellular process. This exchange is facilitated by the adenine nucleotide translocase (ANT), the structure and function of which is critically dependent on the signature phospholipid of mitochondria, cardiolipin (CL). Here we employ multiscale molecular dynamics simulations to investigate CL interactions within a membrane environment. Using simulations at both coarse-grained (CG) and atomistic (AT) resolutions, we identify three CL binding sites on the translocase, in agreement with those seen in crystal structures and inferred from NMR measurements...
October 27, 2016: Biochemistry
https://www.readbyqxmd.com/read/27777789/foxo1-interacts-with-transcription-factor-eb-and-differentially-regulates-mitochondrial-uncoupling-proteins-via-autophagy-in-adipocytes
#11
Longhua Liu, Zhipeng Tao, Louise D Zheng, Joseph P Brooke, Cayleen M Smith, Dongmin Liu, Yun Chau Long, Zhiyong Cheng
Mitochondrial uncoupling proteins (UCPs) are inducible and play an important role in metabolic and redox homeostasis. Recent studies have suggested that FoxO1 controls mitochondrial biogenesis and morphology, but it remains largely unknown how FoxO1 may regulate mitochondrial UCPs. Here we show that FoxO1 interacted with transcription factor EB (Tfeb), a key regulator of autophagosome and lysosome, and mediated the expression of UCP1, UCP2 and UCP3 differentially via autophagy in adipocytes. UCP1 was down-regulated but UCP2 and UCP3 were upregulated during adipocyte differentiation, which was associated with increased Tfeb and autophagy activity...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27773823/short-chain-fatty-acids-induce-ucp2-mediated-autophagy-in-hepatic-cells
#12
Liliana F Iannucci, Jingfeng Sun, Brijesh K Singh, Jin Zhou, Vincent A Kaddai, Antonia Lanni, Paul M Yen, Rohit A Sinha
Short-chain fatty acids (SCFAs) are gut microbial fermentation products derived from dietary fiber sources. Although depletion of gut microflora has been linked to the development of liver disease, the direct effects of SCFAs on intracellular hepatic processes are not well understood. In this study, we demonstrated that the SCFAs, propionate and butyrate, regulated autophagic flux in hepatic cells in a cell-autonomous manner. Induction of autophagy by SCFAs required PPARγ stimulation of Uncoupling Protein 2 (UCP2) expression that was associated with reduced intracellular ATP levels and activation of PRKAA1/AMPK (protein kinase, AMP-activated, alpha 1 catalytic subunit)...
October 20, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27759071/ucp2-expression-is-associated-with-weight-loss-after-hypocaloric-diet-intervention
#13
C Cortes-Oliveira, C F Nicoletti, M A de Souza Pinhel, B A P de Oliveira, D C G Quinhoneiro, N Y Noronha, J S Marchini, W A da Silva Júnior, W S Júnior, C B Nonino
BACKGROUND/OBJECTIVES: Although energy restriction contributes to weight loss, it may also reduce energy expenditure, limiting the success of weight loss in the long term. Studies have described how genetics contributes to the development of obesity, and uncoupling proteins 1 and 2 (UCP1 and UCP2) and beta-3-adrenoceptor (ADRB3) have been implicated in the metabolic pathways that culminate in this condition. This study aimed to evaluate how the UCP1, UCP2 and ADRB3 genes influence weight loss in severely obese women submitted to hypocaloric dietary intervention...
October 19, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27743836/the-ala55val-and-866g-a-polymorphisms-of-the-ucp2-gene-could-be-biomarkers-for-weight-loss-in-patients-who-had-roux-en-y-gastric-bypass
#14
Carolina F Nicoletti, Ana Paula R P de Oliveira, Maria José F Brochado, Marcela A S Pinhel, Bruno A P de Oliveira, Julio S Marchini, José E Dos Santos, Wilson Salgado, Nathalia Moreno Cury, Luiza Ferreira de Araújo, Wilson A Silva, Carla B Nonino
OBJECTIVE: The aim of this study was to investigate whether the Ala55Val and -866G>A polymorphisms of the UCP2 gene are related to weight loss and changes in body composition after bariatric surgery performed by Roux-en-Y gastric bypass (RYGB). METHODS: This longitudinal study enrolled obese patients submitted to RYGB. Data regarding weight (kg), body mass index (kg/m(2)), fat-free mass (FFM; kg), fat mass (kg), weight loss (kg and %), and percent excess weight loss were collected from both preoperative and 1-y postoperative medical records...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27738421/il-15-mediates-mitochondrial-activity-through-a-ppar%C3%AE-dependent-ppar%C3%AE-independent-mechanism-in-skeletal-muscle-cells
#15
Shantaé M Thornton, James E Krolopp, Marcia J Abbott
Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed "myokines," has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPARα and/or PPARδ as targets of IL-15 signaling...
2016: PPAR Research
https://www.readbyqxmd.com/read/27736677/differential-modulation-of-cellular-antioxidant-status-in-zebrafish-liver-and-kidney-exposed-to-low-dose-arsenic-trioxide
#16
Shuvasree Sarkar, Sandip Mukherjee, Ansuman Chattopadhyay, Shelley Bhattacharya
Zebrafish were exposed to a nonlethal dose (1/350LC50; 50µg/L) of As2O3 and sampled at 7, 15, 30, 60 and 90 days of treatment. The oxidative stress response was assessed in terms of time-dependent histopathological changes, lipid peroxidation, GSH status, activities of detoxification enzymes and expression of antioxidant genes in liver and kidney. As2O3 treatment enhanced lipid peroxidation except at day 90 in liver and day 30 in kidney. Glutathione depleted significantly in the liver except on day 30; whereas in kidney, it increased initially but thereafter depleted significantly...
October 10, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27693527/effect-of-hfd-stz-on-expression-of-genes-involved-in-lipid-cholesterol-and-glucose-metabolism-in-rats
#17
Luisa Pozzo, Andrea Vornoli, Ilaria Coppola, Clara Maria Della Croce, Lucia Giorgetti, Pier Giovanni Gervasi, Vincenzo Longo
AIMS: The aim of the study was to evaluate lipid, cholesterol and glucose metabolism in a novel rat model of non-alcoholic fatty liver disease (NAFLD). MAIN METHODS: Rats (Wistar) were fed high fat/cholesterol diet (HFD) and a single low dose (35mg/kg) of streptozotocin (STZ). Collagen and glycogen content, oxidative stress and glucokinase activity were measured using biochemical assays. Other metabolic pathway were assessed by qRT-PCR. KEY FINDINGS: HFD/STZ treated rats, compared to control ones, showed an increase in expression of biomarkers of inflammation (TNFα, IL6), fibrosis (TGFβ), mitochondrial stress (UCP2) and oxidative stress (GSH and carbonylated proteins) but not of ER stress (CHOP, XBP1)...
September 28, 2016: Life Sciences
https://www.readbyqxmd.com/read/27677588/circrna-expression-pattern-and-circrna-mirna-mrna-network-in-the-pathogenesis-of-nonalcoholic-steatohepatitis
#18
Xi Jin, Chun-Yan Feng, Zun Xiang, Yi-Peng Chen, You-Ming Li
The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear, where involvement of circRNA is considered for its active role as "miRNA sponge". Therefore, we aimed to investigate the circRNA expression pattern in NASH and further construct the circRNA-miRNA-mRNA network for in-depth mechanism exploration. Briefly, NASH mice model was established by Methionine and choline deficiency (MCD) diet feeding. Liver circRNA and mRNA profile was initially screened by microarray and ensuing qRT-PCR verification was carried out...
September 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27669335/iron-deficiency-impairs-developing-hippocampal-neuron-gene-expression-energy-metabolism-and-dendrite-complexity
#19
Thomas W Bastian, William C von Hohenberg, Daniel J Mickelson, Lorene M Lanier, Michael K Georgieff
Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. Neonatal rats with fetal/neonatal ID anemia (IDA) have shorter hippocampal CA1 apical dendrites with disorganized branching. ID-induced dendritic structural abnormalities persist into adulthood despite normalization of the iron status. However, the specific developmental effects of neuronal iron loss on hippocampal neuron dendrite growth and branching are unknown...
2016: Developmental Neuroscience
https://www.readbyqxmd.com/read/27651753/uncoupling-protein-2-in-the-glial-response-to-stress-implications-for-neuroprotection
#20
REVIEW
Daniel T Hass, Colin J Barnstable
Reactive oxygen species (ROS) are free radicals thought to mediate the neurotoxic effects of several neurodegenerative disorders. In the central nervous system, ROS can also trigger a phenotypic switch in both astrocytes and microglia that further aggravates neurodegeneration, termed reactive gliosis. Negative regulators of ROS, such as mitochondrial uncoupling protein 2 (UCP2) are neuroprotective factors that decrease neuron loss in models of stroke, epilepsy, and parkinsonism. However, it is unclear whether UCP2 acts purely to prevent ROS production, or also to prevent gliosis...
August 2016: Neural Regeneration Research
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