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https://www.readbyqxmd.com/read/28102595/-they-can-t-find-anything-wrong-with-him-yet-mothers-experiences-of-parenting-an-infant-with-a-prenatally-diagnosed-copy-number-variant-cnv
#1
Allison Werner-Lin, Sarah Walser, Frances K Barg, Barbara A Bernhardt
Chromosome microarray (CMA) testing is used widely in prenatal settings. Some copy number variants (CNVs) detected using CMA are associated with variable or uncertain phenotype and/or possible neurocognitive involvement. Little is known about parenting an infant following such findings. Researchers conducted interviews with 23 mothers of infants diagnosed prenatally with a potentially pathogenic CNV to elicit perspectives on the child's development and disclosure of results to others. Interviews were audiotaped and analyzed for common themes...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28101884/lung-microdialysis-study-of-florfenicol-in-pigs-after-single-intramuscular-administration
#2
B Yang, J D Gao, X Y Cao, Q Y Wang, G Z Sun, J J Yang
For most bacterial lung infections, the concentration of unbound antimicrobial agent in lung interstitial fluid has been considered as the gold standard for estimating the antibacterial efficacy. In this study, the pharmacokinetics of florfenicol (FF) in porcine lung interstitial fluid was investigated after single intramuscular administration at two different doses (20 and 50 mg/kg). Twelve pigs underwent thoracotomy under general anesthesia. Then, the CMA/30 probe was implanted into the lung and perfused at 1 μL/min...
January 19, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28076420/chaperone-mediated-autophagy-protein-bag3-negatively-regulates-ebola-and-marburg-vp40-mediated-egress
#3
Jingjing Liang, Cari A Sagum, Mark T Bedford, Sachdev S Sidhu, Marius Sudol, Ziying Han, Ronald N Harty
Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate the late stage of virus-cell separation. To identify additional WW-domain-bearing host proteins that interact with VP40, we used an EBOV PPxY-containing peptide to screen an array of 115 mammalian WW-domain-bearing proteins...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28073664/extract-of-bulbus-fritillaria-cirrhosa-perturbs-spindle-assembly-checkpoint-induces-mitotic-aberrations-and-genomic-instability-in-human-colon-epithelial-cell-line
#4
Xihan Guo, Juan Ni, Jinglun Xue, Xu Wang
BACKGROUND: Bulbus Fritillaria cirrhosa D. Don (BFC) has been used in China as a folk medicine for the treatment of cough and asthma for more than 2000 years. The antitussive and antiasthmatic effects of BFC have been reported before, nevertheless its toxicity and safety have not been documented. This study investigated the possible effects of BFC on spindle assembly checkpoint (SAC), mitotic fidelity and genomic stability in human NCM460 colon epithelial cells. METHODS: Cells were treated with BFC (0, 20, 40, 80 and 160μg/ml) for 24, 48 and 72h and harvested differently according to the biomarkers observed...
January 7, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28069129/antioxidant-activity-measurement-and-potential-antioxidant-peptides-exploration-from-hydrolysates-of-novel-continuous-microwave-assisted-enzymolysis-of-the-scomberomorus-niphonius-protein
#5
Yipeng Huang, Guihua Ruan, Zhijun Qin, Haiyun Li, Yanjie Zheng
A novel continuous microwave-assisted enzymatic digestion (cMAED) method is proposed for the digestion of protein from Scomberomorus niphonius to obtain potential antioxidant peptides. In this study, bromelain was found to have a high capacity for the digestion of the Scomberomorus niphonius protein. The following cMAED conditions were investigated: protease species, microwave power, temperature, bromelain content, acidity of the substrate solution, and incubation time. At 400W, 40°C, 1500U·g(-1) bromelain, 20% substrate concentration, pH 6...
May 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28068956/cost-effectiveness-of-antibiotic-treatment-strategies-for-community-acquired-pneumonia-results-from-a-cluster-randomized-cross-over-trial
#6
Cornelis H van Werkhoven, Douwe F Postma, Marie-Josee J Mangen, Jan Jelrik Oosterheert, Marc J M Bonten
BACKGROUND: To determine the cost-effectiveness of strategies of preferred antibiotic treatment with beta-lactam/macrolide combination or fluoroquinolone monotherapy compared to beta-lactam monotherapy. METHODS: Costs and effects were estimated using data from a cluster-randomized cross-over trial of antibiotic treatment strategies, primarily from the reduced third payer perspective (i.e. hospital admission costs). Cost-minimization analysis (CMA) and cost-effectiveness analysis (CEA) were performed using linear mixed models...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28066840/task-based-design-of-fluence-field-modulation-in-ct-for-model-based-iterative-reconstruction
#7
Grace J Gang, Jeffrey H Siewerdsen, J Webster Stayman
A task-driven imaging framework for prospective fluence field modulation (FFM) is developed in this paper. The design approach uses a system model that includes a parameterized FFM acquisition and model-based iterative reconstruction (MBIR) for image formation. Using prior anatomical knowledge (e.g. from a low-dose 3D scout image), accurate predictions of spatial resolution and noise as a function of FFM are integrated into a task-based objective function. Specifically, detectability index (d'), a common metric for task-based image quality assessment, is computed for a specific formulation of the imaging task...
July 2016: Conference Proceedings of International Conference on Image Formation in X-Ray Computed Tomography
https://www.readbyqxmd.com/read/28061496/adult-patients-with-congenital-muscular-torticollis-treated-with-bipolar-release-report-of-31-cases
#8
Gun Sang Lee, Myung Ki Lee, Woo Jae Kim, Ho Sang Kim, Jeong Ho Kim, Yun-Suk Kim
OBJECTIVE: We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. METHODS: Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting...
January 1, 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28054205/the-social-and-spatial-patterning-of-life-stress-among-immigrants-in-canada
#9
Lu Wang, Elmer Lara Palacios
While much literature has examined immigrants' health in Canada, less attention has focused specifically on the life stress, an important yet understudied post-migration challenge which may lead to poor coping strategies and negative health consequences. For this study, the pooled 2009-2014 Canadian Community Health Survey (CCHS) was analyzed, using multilevel logistic regression to examine the compositional effects (at an individual level) and areal effects (at a CMA/CA level) on reported high life stress...
January 4, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28050972/registration-of-mri-to-intraoperative-radiographs-for-target-localization-in-spinal-interventions
#10
T De Silva, A Uneri, M D Ketcha, S Reaungamornrat, J Goerres, M W Jacobson, S Vogt, G Kleinszig, A J Khanna, J-P Wolinsky, J H Siewerdsen
Decision support to assist in target vertebra localization could provide a useful aid to safe and effective spine surgery. Previous solutions have shown 3D-2D registration of preoperative CT to intraoperative radiographs to reliably annotate vertebral labels for assistance during level localization. We present an algorithm (referred to as MR-LevelCheck) to perform 3D-2D registration based on a preoperative MRI to accommodate the increasingly common clinical scenario in which MRI is used instead of CT for preoperative planning...
January 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28049522/paradox-of-the-institution-findings-from-a-hospital-labour-ward-ethnography
#11
Elizabeth C Newnham, Lois V McKellar, Jan I Pincombe
BACKGROUND: Interest in the influence of culture on birth practices is on the rise, and with it comes a sense of urgency to implement practices that aid the normalisation and humanisation of birth. This groundswell is occurring despite a broader cultural milieu of escalating technology-use and medicalisation of birth across the globe. Against this background, rates of epidural analgesia use by women in labour are increasing, despite the risk of side effects. Socio-cultural norms and beliefs are likely to influence pain relief choices but there is currently scant research on this topic...
January 3, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28047607/th-cd-207b-09-task-driven-fluence-field-modulation-design-for-model-based-iterative-reconstruction-in-ct
#12
G Gang, J Siewerdsen, J Stayman
PURPOSE: There has been increasing interest in integrating fluence field modulation (FFM) devices with diagnostic CT scanners for dose reduction purposes. Conventional FFM strategies, however, are often either based on heuristics or the analysis of filtered-backprojection (FBP) performance. This work investigates a prospective task-driven optimization of FFM for model-based iterative reconstruction (MBIR) in order to improve imaging performance at the same total dose as conventional strategies...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047378/su-f-j-35-moving-towards-isocentric-prone-breast-setup-with-contralateral-leveling-tattoo-and-couch-move-assistant-cma
#13
K Yang, C Downey, N Suter, L Gott, L Naughton, K Aufiero, S Day, N McGovern, J Brock, K Andreou, J Strasser, C Koprowski, A Raben, H Chen, F Mourtada
PURPOSE: Large setup variability has been observed for prone breast patients due to rotation error. To reduce this uncertainty, we propose a novel implementation of isocentric prone breast method on Elekta linac with couch move assistant (CMA) and on-line KV CBCT. METHODS: Daily CBCT is used to evaluate the prone breast patient positioning uncertainty of proposed isocentric technique against our routine manual clinical setup. Clinical setup involves a manual AP shift from the ipsilateral torso tattoos (2PT) to the treatment iso directly underneath and SSD and flash check...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047217/we-ab-bra-08-correction-of-patient-motion-in-c-arm-cone-beam-ct-using-3d-2d-registration
#14
S Ouadah, M Jacobson, J W Stayman, T Ehtiati, J H Siewerdsen
PURPOSE: Intraoperative C-arm cone-beam CT (CBCT) is subject to artifacts arising from patient motion during the fairly long (∼5-20 s) scan times. We present a fiducial free method to mitigate motion artifacts using 3D-2D image registration that simultaneously corrects residual errors in geometric calibration. METHODS: A 3D-2D registration process was used to register each projection to DRRs computed from the 3D image by maximizing gradient orientation (GO) using the CMA-ES optimizer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043872/extensively-hydrolysed-casein-formula-containing-l-rhamnosus-gg-reduces-the-occurrence-of-other-allergic-manifestations-in-children-with-cow-s-milk-allergy-3-year-randomized-controlled-trial
#15
Roberto Berni Canani, Margherita Di Costanzo, Giorgio Bedogni, Antonio Amoroso, Linda Cosenza, Carmen Di Scala, Viviana Granata, Rita Nocerino
BACKGROUND: Children with cow's milk allergy (CMA) have an increased risk of developing other allergic manifestations (AMs). OBJECTIVE: We performed a parallel-arm randomized controlled trial (RCT) to test whether the administration of an extensively hydrolysed casein formula (EHCF) containing the probiotic L. rhamnosus GG (LGG) can reduce the occurrence of other AMs in CMA children. METHODS: Children with IgE-mediated CMA were randomly allocated to EHCF or EHCF+LGG groups and followed for 36 months...
December 30, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28040141/prenatal-diagnosis-of-smith-magenis-syndrome-in-two-fetuses-with-increased-nuchal-translucency-mild-lateral-ventriculomegaly-and-congenital-heart-defects
#16
Ting-Ying Lei, Ru Li, Fang Fu, Jun-Hui Wan, Yong-Ling Zhang, Xiang-Yi Jing, Can Liao
OBJECTIVE: Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation disorder characterized by an interstitial deletion involving chromosome 17p11.2 containing the retinoic acid-induced 1 (RAI1) gene or due to mutation of RAI1. Few cases have been reported in the medical literature regarding prenatal diagnosis of SMS. We report on the prenatal diagnosis of SMS in two fetuses with increased nuchal translucency (NT), mild lateral ventriculomegaly, and congenital heart defects by whole-genome and high-resolution chromosome microarray analysis (CMA)...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28030757/altered-resting-state-functional-connectivity-of-fear-and-reward-circuitry-in-comorbid-ptsd-and-major-depression
#17
Xi Zhu, Liat Helpman, Santiago Papini, Franklin Schneier, John C Markowitz, Page E Van Meter, Martin A Lindquist, Tor D Wager, Yuval Neria
BACKGROUND: Individuals with comorbid posttraumatic stress disorder and major depressive disorder (PTSD-MDD) often exhibit greater functional impairment and poorer treatment response than individuals with PTSD alone. Research has not determined whether PTSD-MDD is associated with different network connectivity abnormalities than PTSD alone. METHODS: We used functional magnetic resonance imaging (fMRI) to measure resting state functional connectivity (rs-FC) patterns of brain regions involved in fear and reward processing in three groups: patients with PTSD-alone (n = 27), PTSD-MDD (n = 21), and trauma-exposed healthy controls (TEHCs, n = 34)...
December 28, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/28027966/sequence-motifs-associated-with-paternal-transmission-of-mitochondrial-dna-in-the-horse-mussel-modiolus-modiolus-bivalvia-mytilidae
#18
Brent M Robicheau, Sophie Breton, Donald T Stewart
In the majority of metazoans paternal mitochondria represent evolutionary dead-ends. In many bivalves, however, this paradigm does not hold true; both maternal and paternal mitochondria are inherited. Herein, we characterize maternal and paternal mitochondrial control regions of the horse mussel, Modiolus modiolus (Bivalvia: Mytilidae). The maternal control region is 808bp long, while the paternal control region is longer at 2.3kb. We hypothesize that the size difference is due to a combination of repeated duplications within the control region of the paternal mtDNA genome, as well as an evolutionarily ancient recombination event between two sex-associated mtDNA genomes that led to the insertion of a second control region sequence in the genome that is now transmitted via males...
December 24, 2016: Gene
https://www.readbyqxmd.com/read/28025903/antibacterial-coating-on-in-line-suction-respiratory-catheter-to-inhibit-the-bacterial-biofilm-formation-using-renewable-cardanyl-methacrylate-copolymer
#19
Denial Mahata, Ahindra Nag, Santi M Mandal, Golok B Nando
Health-care materials associated with infections are very common in hospital admitted patients. There are generally infected by contact with the catheter or other multipurpose devices which are contacted with microbes. The respiratory infections associated with the pathogens having strong biofilm forming ability on catheter surface, causes life-threatening in every year. Therefore, a catheter coating material is of great interest which inhibits the biofilm formation of pathogens on a catheter to prevent respiratory infections...
January 6, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28012940/development-of-nanostructured-lipid-carriers-containing-salicyclic-acid-for-dermal-use-based-on-the-quality-by-design-method
#20
A Kovács, Sz Berkó, E Csányi, I Csóka
The aim of our present work was to evaluate the applicability of the Quality by Design (QbD) methodology in the development and optimalization of nanostructured lipid carriers containing salicyclic acid (NLC SA). Within the Quality by Design methology, special emphasis is layed on the adaptation of the initial risk assessment step in order to properly identify the critical material attributes and critical process parameters in formulation development. NLC SA products were formulated by the ultrasonication method using Compritol 888 ATO as solid lipid, Miglyol 812 as liquid lipid and Cremophor RH 60® as surfactant...
December 21, 2016: European Journal of Pharmaceutical Sciences
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