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https://www.readbyqxmd.com/read/28337445/rapid-chondrocyte-isolation-for-tissue-engineering-applications-the-effect-of-enzyme-concentration-and-temporal-exposure-on-the-matrix-forming-capacity-of-nasal-derived-chondrocytes
#1
Srujana Vedicherla, Conor Timothy Buckley
Laboratory based processing and expansion to yield adequate cell numbers had been the standard in Autologous Disc Chondrocyte Transplantation (ADCT), Allogeneic Juvenile Chondrocyte Implantation (NuQu®), and Matrix-Induced Autologous Chondrocyte Implantation (MACI). Optimizing cell isolation is a key challenge in terms of obtaining adequate cell numbers while maintaining a vibrant cell population capable of subsequent proliferation and matrix elaboration. However, typical cell yields from a cartilage digest are highly variable between donors and based on user competency...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28333608/morbidity-in-pregnant-women-associated-with-unverified-penicillin-allergies-antibiotic-use-and-group-b-streptococcus-infections
#2
Shilpa H Desai, Michael S Kaplan, Qiaoling Chen, Eric M Macy
CONTEXT: The morbidity potentially associated with unverified penicillin allergy in pregnant women, with and without group B streptococcus (GBS) infections, is unknown. Penicillin allergy testing is safe during pregnancy but is done infrequently. OBJECTIVE: To determine morbidity associated with antibiotic use in a large cohort of pregnant women, with and without an unverified history of penicillin allergy, and with and without GBS. DESIGN: Retrospective...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28328872/the-role-of-the-iacuc-in-ensuring-research-reproducibility
#3
REVIEW
Jerald Silverman, James Macy, Patricia A Preisig
There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28293415/approach-to-the-diagnosis-of-drug-hypersensitivity-reactions-similarities-and-differences-between-europe-and-north-america
#4
REVIEW
M J Torres, A Romano, G Celik, P Demoly, D A Khan, E Macy, M Park, K Blumenthal, W Aberer, M Castells, A Barbaud, C Mayorga, P Bonadonna
Drug hypersensitivity reactions (DHRs) affect an unknown proportion of the general population, and are an important public health problem due to their potential to cause life-threatening anaphylaxis and rare severe cutaneous allergic reactions. DHR evaluations are frequently needed in both ambulatory and hospital settings and have a complex diagnosis that requires a detailed clinical history and other tests that may include in vitro tests and in vivo procedures such as skin tests and drug provocation tests...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28275428/control-of-brain-metastases-with-alectinib-in-anaplastic-lymphoma-kinase-rearranged-lung-cancer
#5
Wang Chun Kwok, Terence Chi Chun Tam, Macy Mei Sze Lui, David Chi Leung Lam, James Chung Man Ho
Brain metastasis from non-small cell lung cancer remains a challenge to physicians. It occurs in 30% of patients with advanced stage adenocarcinoma of lung and is often regarded as the ominous sign of disease progression and death. Alectinib is likely to be a promising agent, even after the failure of crizotinib and ceritinib, for patients with anaplastic lymphoma kinase (ALK) -driven non-small cell lung cancer with brain metastasis, resulting in a durable response for both intracranial and extra-cranial diseases...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28271728/comparing-approaches-to-the-management-of-malignant-pleural-effusions
#6
José M Porcel, Macy Mei-Sze Lui, Andrew D Lerner, Helen E Davies, David Feller-Kopman, Y C Gary Lee
Management of symptomatic malignant pleural effusions is becoming more complex due to the range of treatment options, which include therapeutic thoracenteses, thoracoscopic talc pleurodesis, bedside pleurodesis with talc or other sclerosing agents via small-bore chest catheters, indwelling pleural catheters, surgery, or a combination of some of these procedures. Areas covered: Recent advances for the expanding range of treatment options in malignant pleural effusions are summarized, according to the best available evidence...
March 8, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28261569/development-of-a-proximity-labeling-system-to-map-the-chlamydia-trachomatis-inclusion-membrane
#7
Elizabeth A Rucks, Macy G Olson, Lisa M Jorgenson, Rekha R Srinivasan, Scot P Ouellette
Chlamydia grows within a membrane-bound vacuole termed an inclusion. The cellular processes that support the biogenesis and integrity of this pathogen-specified parasitic organelle are not understood. Chlamydia secretes integral membrane proteins called Incs that insert into the chlamydial inclusion membrane (IM). Incs contain at least two hydrophobic transmembrane domains flanked by termini, which vary in size and are exposed to the host cytosol. In addition, Incs are temporally expressed during the chlamydial developmental cycle...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28255485/fixation-of-a-proximal-humeral-fracture-using-a-novel-intramedullary-cage-construct-following-a-failed-conservative-treatment
#8
John Macy
A majority of proximal humeral fractures are preferably treated conservatively. However, surgical management may be beneficial in proximal humeral fractures with significant displacement or angulation. Unfortunately, the complication rates associated with current surgical procedures for fracture fixation, ORIF and IM devices, can be unacceptably high. A new technology, termed the PH Cage, addresses the technical limitations associated with current technologies available for fixation of proximal humeral fractures...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28244303/autologous-chondrocyte-implantation-in-the-knee-systematic-review-and-economic-evaluation
#9
Hema Mistry, Martin Connock, Joshua Pink, Deepson Shyangdan, Christine Clar, Pamela Royle, Rachel Court, Leela C Biant, Andrew Metcalfe, Norman Waugh
BACKGROUND: The surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. Autologous chondrocyte implantation (ACI) involves laboratory culture of cartilage-producing cells from the knee and then implanting them into the chondral defect...
February 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28174914/penicillin-allergy-testing-a-key-component-of-antibiotic-stewardship
#10
Eric Macy, David A Khan, Mariana C Castells, David M Lang
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28172595/reply-to-macy-et-al
#11
Tamar F Barlam, Sara E Cosgrove
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28128778/the-contributions-of-occupational-science-to%C3%A2-the-readiness-of-long-duration-deep-space-exploration
#12
Janis Davis, Macy Burr, Maria Absi, Rochelle Telles, Howard Koh
BACKGROUND: This study introduces the contributions of occupational science (OS) to the preparation and support of astronauts during long duration space exploration. Given the hostile environment of space, it is not surprising that there is grave deterioration of both physical and mental health when off Earth. However, OS, through occupational therapy (OT), can identify strategies that maintain health and minimize disruptions in task performance for mission success. OBJECTIVE: To determine the gaps in NASA's preparation of astronauts for long duration space exploration and the viable contributions of OT...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/27994720/repair-potential-of-matrix-induced-bone-marrow-aspirate-concentrate-and-matrix-induced-autologous-chondrocyte-implantation-for-talar-osteochondral-repair-patterns-of-some-catabolic-inflammatory-and-pain-mediators
#13
Giovanna Desando, Isabella Bartolotti, Francesca Vannini, Carola Cavallo, Francesco Castagnini, Roberto Buda, Sandro Giannini, Massimiliano Mosca, Erminia Mariani, Brunella Grigolo
OBJECTIVE: The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Aspirate Concentrate (mBMAC) and matrix-induced Autologous Chondrocyte Implantation (mACI) evaluating, on a small number of osteochondral biopsies, the expression of some catabolic, inflammatory, and pain mediators...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27909236/sexual-risk-behaviors-of-african-american-adolescent-females-the-role-of-cognitive-and-religious-factors
#14
Safiya George Dalmida, Natasha Aduloju-Ajijola, Dora Clayton-Jones, Tami L Thomas, Ricardo J Erazo Toscano, Rashunda Lewis, Terri Fleming, Shirley Taylor, Macie Lunyong
INTRODUCTION: African American (AA) high school-age girls are more likely to have had sex before age 13 years and have higher rates of all sexually transmitted infections. Cognition and religion/spirituality are associated with adolescent sexuality, therefore, the purpose of this study was to identify cognitive and religious substrates of AA girls' risky sexual behaviors. METHOD: A descriptive study was conducted with 65 AA girls aged 15 to 20 years using computerized questionnaires and cognitive function tasks...
November 30, 2016: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/27896880/a-community-based-cross-sectional-survey-of-medication-utilization-among-chronic-disease-patients-in-china
#15
Mark A Strand, Kirstin Gramith, Macy Royston, Xiaoxi Wang, Judith Perry, Curt Elliott
OBJECTIVES: To determine medication use patterns and associated health outcomes in Chinese individuals with diabetes, hypertension or hyperlipidaemia. METHODS: This community-based cross-sectional study was done in a north China city of 300 000 people. Participants were recruited by poster and phone call through Community Health Centres. Data were collected on 638 Chinese individuals. Interviews were done to screen for disease and health behaviours. Fasting blood was collected and analyzed...
November 29, 2016: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27881791/measuring-substance-use-among-system-involved-ipv-survivors-a-research-note
#16
Jennifer E O'Brien, Dania Ermentrout, Wen Li, Sarah Dababnah, Cynthia F Rizo, Rebecca J Macy
This research note presents findings from a qualitative study exploring female, system-involved intimate partner violence (IPV) survivors' perspectives on substance use disclosure in the context of research studies. The study sample includes 22 women who completed a court- and/or child protective services (CPS)-mandated IPV parenting program. Analyses revealed three key areas of participants' perspectives on substance use assessment and disclosure: (a) administration setting/format and measurement clarity, (b) administrator characteristics, and (c) repercussions due to breach of confidentiality...
November 22, 2016: Violence Against Women
https://www.readbyqxmd.com/read/27881381/two-year-outcomes-of-a-randomized-trial-investigating-a-6-week-return-to-full-weightbearing-after-matrix-induced-autologous-chondrocyte-implantation
#17
Jay R Ebert, Peter K Edwards, Michael Fallon, Timothy R Ackland, Gregory C Janes, David J Wood
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging outcomes in treating patients with knee cartilage defects. Postoperatively, the time required to attain full weightbearing (WB) remains conservative. HYPOTHESIS: We hypothesized that patients would have no significant clinical or radiological differences or graft complications after an 8-week or 6-week return to full WB after MACI. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27876261/cartilage-repair-strategies-in-the-knee-a-survey-of-turkish-surgeons
#18
Nurzat Elmalı, Reha Tandoğan, Murat Demirel, Murat Bozkurt, Tahsin Beyzadeoglu
OBJECTIVES: The purpose of this study was to analyze the trends in cartilage repair strategies among Turkish orthopedic surgeons for isolated focal (osteo)chondral lesions of the knee joint. MATERIALS AND METHODS: A web-based survey of 21 questions consisting of surgical indications, techniques and time to return to sports was developed to investigate the preferences of members of the TOTBID and the TUSYAD. RESULTS: A total of 147 surgeons answered the questionnaire...
October 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27825388/impact-of-cyp19a1-and-esr1-variants-on-early-onset-side-effects-during-combined-endocrine-therapy-in-the-text-trial
#19
Harriet Johansson, Kathryn P Gray, Olivia Pagani, Meredith M Regan, Giuseppe Viale, Valentina Aristarco, Debora Macis, Antonella Puccio, Susanne Roux, Rudolf Maibach, Marco Colleoni, Manuela Rabaglio, Karen N Price, Alan S Coates, Richard D Gelber, Aron Goldhirsch, Roswitha Kammler, Bernardo Bonanni, Barbara A Walley
BACKGROUND: Single nucleotide polymorphisms (SNPs) in the estrogen receptor 1 (ESR1) and cytochrome P450 19A1 (CYP19A1) genes have been associated with breast cancer risk, endocrine therapy response and side effects, mainly in postmenopausal women with early breast cancer. This analysis aimed to assess the association of selected germline CYP19A1 and ESR1 SNPs with early-onset hot flashes, sweating and musculoskeletal symptoms in premenopausal patients enrolled in the Tamoxifen and Exemestane Trial (TEXT)...
November 8, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27805950/three-year-md-programs-perspectives-from-the-consortium-of-accelerated-medical-pathway-programs-campp
#20
Joan Cangiarella, Tonya Fancher, Betsy Jones, Lisa Dodson, Shou Ling Leong, Matthew Hunsaker, Robert Pallay, Robert Whyte, Amy Holthouser, Steven B Abramson
In the last decade, there has been renewed interest in three-year MD pathway programs. In 2015, with support from the Josiah Macy Jr., Foundation, eight North American medical schools with three-year accelerated medical pathway programs formed the Consortium of Accelerated Medical Pathway Programs (CAMPP). The schools are two campuses of the Medical College of Wisconsin; McMaster University Michael G. DeGroote School of Medicine; Mercer University School of Medicine; New York University School of Medicine; Penn State College of Medicine; Texas Tech University Health Sciences Center School of Medicine; University of California, Davis School of Medicine; and University of Louisville School of Medicine...
November 1, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
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