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https://www.readbyqxmd.com/read/29034009/a-multicenter-randomized-study-of-decitabine-as-epigenetic-priming-with-induction-chemotherapy-in-children-with-aml
#1
Lia Gore, Timothy J Triche, Jason E Farrar, Daniel Wai, Christophe Legendre, Gerald C Gooden, Winnie S Liang, John Carpten, David Lee, Frank Alvaro, Margaret E Macy, Carola Arndt, Philip Barnette, Todd Cooper, Laura Martin, Aru Narendran, Jessica Pollard, Soheil Meshinchi, Jessica Boklan, Robert J Arceci, Bodour Salhia
BACKGROUND: Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label study to evaluate decitabine pre-treatment before standard induction therapy in children with newly diagnosed AML to assess safety and tolerability and explore a number of biologic endpoints. RESULTS: Twenty-four patients were fully assessable for all study objectives per protocol (10 in Arm A = epigenetic priming induction, 14 in Arm B = standard induction)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29030676/papillary-thyroid-carcinoma-ptc-in-children-and-adults-comparison-of-initial-presentation-and-long-term-postoperative-outcome-in-4432-patients-consecutively-treated-at-the-mayo-clinic-during-eight-decades-1936-2015
#2
Ian D Hay, Tammi R Johnson, Suneetha Kaggal, Megan S Reinalda, Nicole M Iniguez-Ariza, Clive S Grant, Siobhan T Pittock, Geoffrey B Thompson
BACKGROUND: Contemporary guidelines for managing PTC advise an approach wherein primary tumor and regional metastases (RM) are completely resected at first surgery and radioiodine remnant ablation (RRA) is restricted to high-risk patients, policies our group has long endorsed. To assess our therapeutic efficacy, we studied 190 children and 4242 adults consecutively treated during 1936-2015. SUBJECTS AND METHODS: Mean follow-up durations for children and adults were 26...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29023245/education-in-pediatrics-across-the-continuum-epac-first-steps-toward-realizing-the-dream-of-competency-based-education
#3
John S Andrews, James F Bale, Jennifer B Soep, Michele Long, Carol Carraccio, Robert Englander, Deborah Powell
The Education in Pediatrics Across the Continuum (EPAC) Study Group is developing the first competency-based, time-variable progression from undergraduate medical education (UME) to graduate medical education (GME) in the history of medical education in the United States. EPAC, an innovation project sponsored by the Association of American Medical Colleges (AAMC) and supported by the Josiah Macy Jr. Foundation, was developed through a collaboration between 5 medical schools and multiple professional organizations with an interest in undergraduate and graduate medical education...
October 11, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28991947/regional-variation-in-standardized-costs-of-care-at-children-s-hospitals
#4
Jennifer A Jonas, Samir S Shah, Isabella Zaniletti, Matthew Hall, Jeffrey D Colvin, Laura M Gottlieb, Marion R Sills, Jessica Bettenhausen, Rustin B Morse, Michelle L Macy, Evan S Fieldston
OBJECTIVE: (1) To evaluate regional variation in costs of care for 3 inpatient pediatric conditions, (2) assess potential drivers of variation, and (3) estimate cost savings from reducing variation. DESIGN/SETTING: Retrospective cohort study of hospitalizations for asthma, diabetic ketoacidosis (DKA), and acute gastroenteritis (AGE) at 46 children<s hospitals from October 2014 to September 2015. MEASUREMENTS: Variation in trimmed standardized costs were assessed within and across regions...
October 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28980022/-current-overview-of-cartilage-regeneration-procedures
#5
REVIEW
H Schenker, M Wild, B Rath, M Tingart, A Driessen, V Quack, M Betsch
BACKGROUND: Cartilage is an avascular, alymphatic and non-innervated tissue with limited intrinsic repair potential. The high prevalence of cartilage defects and their tremendous clinical importance are a challenge for all treating physicians. AIM: This article provides the reader with an overview about current cartilage treatment options and their clinical outcome. METHODS: Microfracture is still considered the gold standard in the treatment of small cartilage lesions...
October 4, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28973267/macy-s-fourth-of-july-fireworks-2017
#6
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28964904/is-hunger-important-to-model-in-fmri-visual-food-cue-reactivity-paradigms-in-adults-with-obesity-and-how-should-this-be-done
#7
Shao-Hua Chin, Chanaka N Kahathuduwa, Macy B Stearns, Tyler Davis, Martin Binks
We considered 1) influence of self-reported hunger in behavioral and fMRI food-cue reactivity (fMRI-FCR) 2) optimal methods to model this. Adults (N = 32; 19-60 years; F = 21; BMI 30-39.9 kg/m(2)) participated in an fMRI-FCR task that required rating 240 images of food and matched objects for 'appeal'. Hunger, satiety, thirst, fullness and emptiness were measured pre- and post-scan (visual analogue scales). Hunger, satiety, fullness and emptiness were combined to form a latent factor (appetite). Post-vs...
September 28, 2017: Appetite
https://www.readbyqxmd.com/read/28960666/return-visit-admissions-may-not-indicate-quality-of-emergency-department-care-for-children
#8
Marion R Sills, Michelle L Macy, Keith E Kocher, Amber K Sabbatini
OBJECTIVE: To test the hypothesis that in-hospital outcomes are worse among children admitted during a return ED visit than among those admitted during an index ED visit. METHODS: Retrospective analysis of ED visits by children age 0-17 to hospitals in Florida and New York in 2013. Children hospitalized during an ED return visit within 7 days were classified as "ED return admissions" (discharged at ED index visit and admitted at return visit) or "readmissions" (admission at both ED index and return visits)...
September 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28958745/are-cephalosporins-safe-for-use-in-penicillin-allergy-without-prior-allergy-evaluation
#9
REVIEW
Eric Macy, Kimberly G Blumenthal
No abstract text is available yet for this article.
September 22, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28955187/comparative-medicine-an-inclusive-crossover-discipline%C3%A2-%C3%A2-%C3%A2
#10
REVIEW
James Macy, Tamas L Horvath
Comparative Medicine is typically defined as a discipline which relates and leverages the biological similarities and differences among animal species to better understand the mechanism of human and animal disease. It has also been defined as a field of study concentrating on similarities and differences between human and veterinary medicine and is increasingly associated with animal models of human disease, including the critical role veterinarians, animal resource centers, and Institutional Animal Care and Use Committees play in facilitating and ensuring humane and reproducible laboratory animal care and use...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28953565/resident-empowerment-as-a-driving-theme-of-graduate-medical-education-reform
#11
George E Thibault
Through a series of six recent conferences, the Josiah Macy Jr. Foundation wanted to try to change the discussion about graduate medical education (GME) reform to one that is about the innovations needed to better prepare residents for the changing world of practice they will be entering and for meeting the needs of the patient population they will serve. These conferences featured some of the encouraging innovations in GME that are occurring at local and regional levels. An ongoing theme from many of these reforms is the empowerment of residents...
September 26, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28935001/lack-of-effect-of-murine-astrovirus-infection-on-dextran-sulfate-induced-colitis-in-nlrp3-deficient-mice
#12
Susan R Compton, Carmen J Booth, James D Macy
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. MuAstV is found predominantly in the gastrointestinal tract of mice. Human and turkey astroviruses have been shown to disrupt tight junctions in the intestinal epithelium. The potential of MuAstV to alter research results was tested in a well-established dextran sodium sulfate (DSS)-induced colitis model in Nod-like receptor 3 (NLRP3)-deficient mice. This model offers a direct approach to determine whether MuAstV, as a component of the mouse microbiome, contributes to the issue of poor reproducibility in murine inflammatory bowel disease research...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28928748/a-peptide-fc-opsonin-with-pan-amyloid-reactivity
#13
James S Foster, Angela D Williams, Sallie Macy, Tina Richey, Alan Stuckey, Daniel Craig Wooliver, Richa Koul-Tiwari, Emily B Martin, Stephen J Kennel, Jonathan S Wall
There is a continuing need for therapeutic interventions for patients with the protein misfolding disorders that result in systemic amyloidosis. Recently, specific antibodies have been employed to treat AL amyloidosis by opsonizing tissue amyloid deposits thereby inducing cell-mediated dissolution and organ improvement. To develop a pan-amyloid therapeutic agent, we have produced an Fc-fusion product incorporating a peptide, p5, which binds many if not all forms of amyloid. This protein, designated Fcp5, expressed in mammalian cells, forms the desired bivalent dimer structure and retains pan-amyloid reactivity similar to the p5 peptide as measured by immunosorbent assays, immunohistochemistry, surface plasmon resonance, and pulldown assays using radioiodinated Fcp5...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28921428/production-of-recombinant-factor-viii-in-human-cell-lines
#14
Daianne Maciely Carvalho Fantacini, Virgínia Picanço-Castro
Human cell lines can produce recombinant proteins much more similar to their natural counterpart, compared to other mammalian cell lines, reducing potential immunogenic reactions. Recombinant proteins produced in nonhuman cells can have in its structure glycan epitopes, such as Galα1,3-Gal (alpha-Gal) and N-glycolylneuraminic acid (Neu5Gc) residues, that are antigenic to humans and can potentially affect the efficacy of the recombinant product. Therefore, the production of recombinant factor VIII (rFVIII) in human cell lines is a new approach to avoid nonhuman glycosylation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28920818/biochemistry-panel-reference-intervals-for-juvenile-goldfish-carassius-auratus
#15
Laura A Adamovicz, Macy R Trosclair, Gregory A Lewbart
Reference intervals for diagnostic tests are vitally important for clinical decision making. Despite the popularity of pet goldfish (Carassius auratus), reference intervals have not been generated for routine biochemistry panel analytes in this species. This study establishes de novo reference intervals for packed cell volume and total solids, using 47 apparently healthy immature goldfish, and for 11 common chemistry panel analytes (albumin, aspartate aminotransferase, calcium, creatine kinase, globulin, blood glucose, sodium, potassium, phosphorous, total protein, and uric acid) using 39 immature goldfish...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28917810/nano-hemoglobin-film-based-sextet-state-biomemory-device-by-cross-linked-photosensitive-hapten-monomer
#16
Remziye Güzel, Arzu Ersöz, Recep Ziyadanoğulları, Rıdvan Say
In this study, a biomemory device, consisting of hemoglobin (Hb) cross-linked by MACys-Ru(bipyr)2-MACys) photosensitive monomer cross-linkers, which have memory effect through both Ru(3+/2+) in hapten monomer and Fe(3+/2+) in redox active center of Hb through multi-charge transfer mechanism, has been improved. Cyclic voltammetry (CV) has been used to determine the redox property of the Hb cross-linked MACys-Ru(bipyr)2-MACys) hapten. Three memory functions, writing, reading and erasing of the fabricated biomemory device, have been accomplished by chronoamperometry (CA) and open-circuit potential amperometry (OCPA)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28910133/a-comparison-of-2-year-outcomes-in-patients-undergoing-tibiofemoral-or-patellofemoral-matrix-induced-autologous-chondrocyte-implantation
#17
Jay R Ebert, Adrian Schneider, Michael Fallon, David J Wood, Gregory C Janes
BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) has demonstrated encouraging clinical results in the treatment of knee chondral defects. However, earlier studies suggested that chondrocyte implantation in the patellofemoral (PF) joint was less effective than in the tibiofemoral (TF) joint. PURPOSE: To compare the radiological and clinical outcomes of those undergoing MACI to either the femoral condyles or PF joint. STUDY DESIGN: Cohort study; Level of evidence, 3...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28837082/rna-interference-and-bmp-2-stimulation-allows-equine-chondrocytes-redifferentiation-in-3d-hypoxia-cell-culture-model-application-for-matrix-induced-autologous-chondrocyte-implantation
#18
Rodolphe Rakic, Bastien Bourdon, Magalie Hervieu, Thomas Branly, Florence Legendre, Nathalie Saulnier, Fabrice Audigié, Stéphane Maddens, Magali Demoor, Philippe Galera
As in humans, osteoarthritis (OA) causes considerable economic loss to the equine industry. New hopes for cartilage repair have emerged with the matrix-associated autologous chondrocyte implantation (MACI). Nevertheless, its limitation is due to the dedifferentiation occurring during the chondrocyte amplification phase, leading to the loss of its capacity to produce a hyaline extracellular matrix (ECM). To enhance the MACI therapy efficiency, we have developed a strategy for chondrocyte redifferentiation, and demonstrated its feasibility in the equine model...
August 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#19
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28765450/the-21-st-century-dental-curriculum-a-framework-for-understanding-current-models
#20
Denise K Kassebaum, Lisa A Tedesco
This article provides an overview of the emergence of professional education and academic dentistry, in particular into the comprehensive research university. The development of academic dentistry as a vital member of the academic health center at the research university and beyond is described. Summaries are provided of major studies and innovations in dental education models and curricula, ranging from the Gies report in 1926 to the 1995 Institute of Medicine study Dental Education at the Crossroads, the U...
August 2017: Journal of Dental Education
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