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Sara García-Sánchez, Josep Lluís Matalí, María Martín-Fernández, Marta Pardo, Maria Lleras, Carmina Castellano-Tejedor, Josep Maria Haro
Cannabis is the illicit substance most widely used by adolescents. Certain personality traits such as impulsivity and sensation seeking, and the subjective effects experienced after substance use (e.g. euphoria or relaxation) have been identified as some of the main etiological factors of consumption. This study aims to categorize a sample of adolescent cannabis users based on their most dominant personality traits (internalizing and externalizing profile). Then, to make a comparison of both profiles considering a set of variables related to consumption, clinical severity and subjective effects experienced...
October 6, 2016: Adicciones
Mark R Zonfrillo, Michelle L Macy, Lawrence J Cook, Tomohiko Funai, Rachel M Stanley, James M Chamberlain, Rebecca M Cunningham, Elizabeth R Alpern
BACKGROUND: Childhood injuries are increasingly treated in emergency departments (EDs) but the relationship between injury severity and ED resource utilization has not been evaluated. The objective of this study was to compare resource utilization for pediatric injury-related ED visits across injury-severity levels and with non-injury visits, using standardized, validated scales. METHODS: A retrospective analysis of 2004-2008 ED visits from the Pediatric Emergency Care Applied Research Network Core Data Project...
December 2016: Injury Epidemiology
Justus Gille, Peter Behrens, Arndt Peter Schulz, Ralf Oheim, Benjamin Kienast
INTRODUCTION: A prospective clinical investigation was carried out in order to clarify whether Matrix-associated autologous chondrocyte implantation (MACI) results in clinical improvement at long-term follow-up. HYPOTHESIS: MACI will result in clinical improvement at long-term follow-up. STUDY DESIGN: Case series; level of evidence, 4. METHODS: Thirty-eight patients were treated with MACI. These patients were evaluated for up to a mean of 16 years (range 15-17 years) after the intervention...
October 2016: Cartilage
Jordan Mills, Patrick Van Winkle, Macy Shen, Christina Hong, Sharon Hudson
CONTEXT: Vaccination against the human papillomavirus (HPV) decreases risks of cancer and genital warts and the need for gynecologic procedures, yet nationwide vaccination rates are low. Previous surveys exploring this phenomenon have not included inputfrom nurses and medical assistants, who play integral roles in HPV vaccine delivery. OBJECTIVE: To understand perceptions of HPV vaccine delivery among physicians, nurses, and medical assistants in a large integrated health care system in Southern California...
September 14, 2016: Permanente Journal
Jonathan C Riboh, Gregory L Cvetanovich, Brian J Cole, Adam B Yanke
PURPOSE: While numerous randomized controlled trials have compared surgical treatments for cartilage defects of the knee, the comparative efficacy of these treatments is still poorly understood. The goal of this network meta-analysis was to synthesize these randomized data into a comprehensive model allowing pairwise comparisons of all treatment options and treatment rankings based on multiple measures of efficacy. We hypothesized that advanced chondral procedures would have improved outcomes when compared to microfracture...
September 7, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Jay R Ebert, Michael Fallon, David J Wood, Gregory C Janes
BACKGROUND: While midterm outcomes after matrix-induced autologous chondrocyte implantation (MACI) are encouraging, the procedure permits an arthroscopic approach that may reduce the morbidity of arthrotomy and permit accelerated rehabilitation. HYPOTHESIS: A significant improvement in clinical and radiological outcomes after arthroscopic MACI will exist through to 5 years after surgery. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We prospectively evaluated the first 31 patients (15 male, 16 female) who underwent MACI via arthroscopic surgery to address symptomatic tibiofemoral chondral lesions...
September 1, 2016: American Journal of Sports Medicine
Gavitt A Woodard, Jane C Crockard, Carolyn Clary-Macy, Clara T Zoon-Besselink, Kirk Jones, Wolfgang Michael Korn, Andrew H Ko, Alexander R Gottschalk, Stanley J Rogers, David M Jablons
BACKGROUND: There is a clear survival benefit to neoadjuvant chemoradiation prior to esophagectomy for patients with stages II-III esophageal cancer. A minimally invasive esophagectomy approach may decrease morbidity but is more challenging in a previously radiated field and therefore patients who undergo neoadjuvant chemoradiation may experience more postoperative complications. METHODS: A prospective database of all esophageal cancer patients who underwent attempted hybrid minimally invasive Ivor Lewis esophagectomy was maintained between 2006 and 2015...
August 28, 2016: Journal of Surgical Oncology
Jessica L Irwin, Marjorie Beeghly, Katherine L Rosenblum, Maria Muzik
The postpartum period brings a host of biopsychosocial, familial, and economic changes, which may be challenging for new mothers, especially those with trauma histories. Trauma-exposed women are at heightened risk for psychiatric symptomatology and reduced quality of life. The current study sought to evaluate whether a set of hypothesized promotive factors assessed during the first 18 months postpartum (positive parenting, family cohesion, and maternal resilience) are associated with life satisfaction in this population, after controlling for income and postpartum psychiatric symptoms...
August 12, 2016: Archives of Women's Mental Health
Harriet Johansson, Sara Gandini, Davide Serrano, Jennifer Gjerde, Monia Lattanzi, Debora Macis, Aliana Guerrieri-Gonzaga, Valentina Aristarco, Gunnar Mellgren, Ernst Lien, Andrea DeCensi, Bernardo Bonanni
Decreased CYP2D6 activity is associated with lower levels of active tamoxifen metabolites. We examined the impact of CYP2D6 genotype on tamoxifen pharmacokinetics, biomarker activity, and efficacy in a pooled analysis of low-dose tamoxifen. Four randomized breast cancer prevention trials of very-low-dose (1 mg/day, n = 52 or 10 mg/week, n = 152) or low-dose tamoxifen (5 mg/day, n = 171) were pooled. DNA from 367 subjects was genotyped for CYP2D6 alleles associated with absent (PM allele: *3, *4, *5, *6, *7, *8, *12, and *14), reduced (IM allele: *9, *10, *17, *29, *41), normal (EM allele), or increased (UM: *XN) enzyme activity...
August 2016: Breast Cancer Research and Treatment
Ekua Yorke, Adrienne Melck, Sam M Wiseman
Papillary thyroid cancer (PTC) is the most common endocrine malignancy. Observed clinical and pathological differences between the sexes of PTC patients have been reported. There is currently no consensus regarding the impact of sex on PTC prognostication. We studied 566 PTC patients and observed that there was a higher PTC incidence in women, that PTC diagnosis was more challenging in women, and that men tended to present with larger cancers. However, once PTC is diagnosed, both sexes have a similar cancer prognosis, as evaluated using the MACIS (Metastasis, Age, Completeness of Resection, Invasion, Size) score...
August 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Paolo Montuschi, Mario Malerba, Giuseppe Macis, Nadia Mores, Giuseppe Santini
Combining individual drugs in a single inhaler is the most convenient way to deliver triple therapy. A long-acting muscarinic receptor antagonist (LAMA) added to an inhaled corticosteroid (ICS)/long-acting β2-adrenoceptor agonist (LABA) fixed-dose combination (FDC) can improve efficacy of pharmacological treatment of patients with chronic obstructive pulmonary disease (COPD). New inhaled ICS/LABA/LAMA FDCs, including fluticasone furoate/vilanterol/umeclidinium, budesonide/formoterol/glycopyrronium and beclometasone/formoterol/glycopyrronium, are in Phase III of clinical development for COPD...
July 21, 2016: Drug Discovery Today
Matthew J Roberts, John W Yaxley, Geoffrey D Coughlin, Troy R J Gianduzzo, Rachel C Esler, Nigel T Dunglison, Suzanne K Chambers, Robyn J Medcraft, Clement W K Chow, Horst Joachim Schirra, Renee S Richards, Nicholas Kienzle, Macy Lu, Ian Brereton, Hema Samaratunga, Joanna Perry-Keene, Diane Payton, Chikara Oyama, Suhail A Doi, Martin F Lavin, Robert A Gardiner
BACKGROUND: Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether these drugs favourably alter selected parameters in men with clinically-localized, aggressive PCa. METHODS/DESIGN: This prospective phase II randomized, controlled window trial is recruiting men with clinically significant PCa, confirmed by biopsy following multiparametric MRI and intending to undergo radical prostatectomy...
September 2016: Contemporary Clinical Trials
Jaroslaw Jendrzejewski, Sandya Liyanarachchi, Rebecca Nagy, Leigha Senter, Paul E Wakely, Andrew Thomas, Fadi Nabhan, Huiling He, Wei Li, Krzysztof Sworczak, Matthew D Ringel, Lawrence S Kirschner, Albert de la Chapelle
BACKGROUND: Papillary thyroid cancer (PTC) is reported to be highly heritable in epidemiological studies. Genome-wide association studies (GWAS) have uncovered several variants associated with PTC predisposition. It remains unknown whether these variants might contribute to better clinical stratification of PTC patients. METHODS: In order to assess the usefulness of germline genetic analyses in the management of PTC patients, the genotypes of five variants (rs965513, rs944289, rs116909374, rs2439302, and rs966423) were determined in 1216 PTC patients and 1416 controls...
September 2016: Thyroid: Official Journal of the American Thyroid Association
E Thomas Danielsen, Morten E Moeller, Naoki Yamanaka, Qiuxiang Ou, Janne M Laursen, Caecilie Soenderholm, Ran Zhuo, Brian Phelps, Kevin Tang, Jie Zeng, Shu Kondo, Christian H Nielsen, Eva B Harvald, Nils J Faergeman, Macy J Haley, Kyle A O'Connor, Kirst King-Jones, Michael B O'Connor, Kim F Rewitz
Steroid hormones control important developmental processes and are linked to many diseases. To systematically identify genes and pathways required for steroid production, we performed a Drosophila genome-wide in vivo RNAi screen and identified 1,906 genes with potential roles in steroidogenesis and developmental timing. Here, we use our screen as a resource to identify mechanisms regulating intracellular levels of cholesterol, a substrate for steroidogenesis. We identify a conserved fatty acid elongase that underlies a mechanism that adjusts cholesterol trafficking and steroidogenesis with nutrition and developmental programs...
June 20, 2016: Developmental Cell
Kimberly G Blumenthal, Miguel A Park, Eric M Macy
No abstract text is available yet for this article.
August 2016: Annals of Allergy, Asthma & Immunology
Sarah E Moore, Katayoon Kasaian, Steven Jones, Adrienne Melck, Sam M Wiseman
A cancer-related factor that is not included in papillary thyroid cancer (PTC) prognostic scoring systems is bilaterality. While it may seem that bilaterality should be considered during the management of PTC, its clinical importance has been debated. This controversy exists because the extent of surgery for PTC has not been found to affect survival in low-risk individuals, despite their potential for PTC bilaterality. We sought to determine if PTC bilaterality is a cancer prognosticator based upon its association with known clinical and pathological PTC prognosticators, and MACIS scores...
June 2016: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Mark R Zonfrillo, Michelle L Macy, Lawrence J Cook, Tomohiko Funai, Rachel M Stanley, James M Chamberlain, Rebecca M Cunningham, Elizabeth R Alpern
BACKGROUND: Childhood injuries are increasingly treated in emergency departments (EDs) but the relationship between injury severity and ED resource utilization has not been evaluated. The objective of this study was to compare resource utilization for pediatric injury-related ED visits across injury-severity levels and with non-injury visits, using standardized, validated scales. METHODS: A retrospective analysis of 2004-2008 ED visits from the Pediatric Emergency Care Applied Research Network Core Data Project...
2016: Injury Epidemiology
James McLoughlin, Laurentia Nodit, R Eric Heidel, Stuart Van Meter, Sallie Macy, Daniel Kestler
BACKGROUND: Approximately 15% of gastrointestinal stromal tumors (GISTs) will not respond to tyrosine kinase inhibitors and drug resistance can develop over time. For refractory tumors, additional therapies are needed. Odontogenic ameloblast-associated protein (ODAM) is expressed in some epithelial malignancies and can correlate with clinical outcomes. This study evaluated ODAM and its relationship to phosphatase and tensin homolog on chromosome 10 (PTEN) and phosphorylation of AKT to an activated state (pAKT) in GISTs...
May 15, 2016: Journal of Surgical Research
Kurren S Gill, Patrick Tassone, James Hamilton, Nikolaus Hjelm, Adam Luginbuhl, David Cognetti, Madalina Tuluc, Ubaldo Martinez-Outschoorn, Jennifer M Johnson, Joseph M Curry
Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic thyroid cancer, however, remains poorly characterized, and studies analyzing the role of multicompartment metabolism in thyrocyte oncogenesis are sparse. We present a review of the current knowledge on cellular metabolism in non-cancerous and cancerous thyroid tissues, focusing on the monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer mitochondrial membrane TOMM20...
February 2016: Journal of thyroid disorders & therapy
Daianne Maciely Carvalho Fantacini, Aparecida Maria Fontes, Mário Soares de Abreu Neto, Dimas Tadeu Covas, Virgínia Picanço-Castro
OBJECTIVES: The capacity of a human cell line to secrete recombinant factor VIII with a F309S point mutation was investigated, as was the effect of the addition of chemical chaperones (betaine and sodium-4-phenylbutyrate) on the secretion of factor VIII. METHODS: This work used a vector with a F309S mutation in the A1 domain to investigate FVIII production in the HEK 293 human cell line. Factor VIII activity was measured by chromogenic assay. Furthermore, the effects of chemical drugs on the culture were evaluated...
April 2016: Revista Brasileira de Hematologia e Hemoterapia
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