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https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#1
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28765450/the-21-st-century-dental-curriculum-a-framework-for-understanding-current-models
#2
Denise K Kassebaum, Lisa A Tedesco
This article provides an overview of the emergence of professional education and academic dentistry, in particular into the comprehensive research university. The development of academic dentistry as a vital member of the academic health center at the research university and beyond is described. Summaries are provided of major studies and innovations in dental education models and curricula, ranging from the Gies report in 1926 to the 1995 Institute of Medicine study Dental Education at the Crossroads, the U...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28765382/health-care-expenditures-and-utilization-for-children-with-noncomplex-chronic-disease
#3
Erik R Hoefgen, Annie L Andrews, Troy Richardson, Matthew Hall, John M Neff, Michelle L Macy, Jessica L Bettenhausen, Samir S Shah, Katherine A Auger
BACKGROUND: Pediatric health care expenditures and use vary by level of complexity and chronic illness. We sought to determine expenditures and use for children with noncomplex chronic diseases (NC-CDs). METHODS: We performed a retrospective, cross-sectional analysis of Medicaid enrollees (ages 0-18 years) from January 1, 2012, through December 31, 2013, using administrative claims (the Truven MarketScan Medicaid Database). Patients were categorized by chronicity of illness by using 3M Health Information System's Clinical Risk Groups (CRGs) as follows: without chronic diseases (WO-CDs) (CRG 1-2), NC-CDs (CRG 3-5), and complex chronic diseases (C-CDs) (CRG 6-9)...
August 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/28749065/concise-review-the-high-cost-of-high-tech-medicine-planning-ahead-for-market-access
#4
REVIEW
Dawn Driscoll, Stephanie Farnia, Panos Kefalas, Richard T Maziarz
Cellular therapies and other regenerative medicines are emerging as potentially transformative additions to modern medicine, but likely at a staggering financial cost. Public health care systems' budgets are already strained by growing and aging populations, and many private insurer's budgets are equally stretched. The current systems that most payers employ to manage their cash flow are not structured to absorb a sudden onslaught of very expensive prescriptions for a large portion of their covered population...
August 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28728623/veterans-affairs-primary-care-provider-perceptions-of-insomnia-treatment
#5
Christi S Ulmer, Hayden B Bosworth, Jean C Beckham, Anne Germain, Amy S Jeffreys, David Edelman, Stephanie Macy, Angela Kirby, Corrine I Voils
STUDY OBJECTIVES: Insomnia is a widespread issue among United States adults and rates of insomnia among veterans are even higher than the general population. Prior research examining primary care provider (PCP) perspectives on insomnia treatment found that: sleep hygiene and pharmacotherapy are the primary treatments offered; PCPs tend to focus on perceived causes of insomnia rather than the insomnia itself; and neither patients nor providers are satisfied with insomnia treatment options...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28724490/murine-astrovirus-infection-and-transmission-in-neonatal-cd1-mice
#6
Susan R Compton, Carmen J Booth, James D Macy
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. Our goal was to determine the duration of MuAstV infection, susceptibility of pups, and efficacy of soiled-bedding sentinels and environmental monitoring. Eight CD1 dams and their litters of 3-d-old pups and 8 CD1 dams and their litters of 13-d-old mice were inoculated orally with MuAstV. Neither dams nor offspring demonstrated any clinical signs, and MuAstV had little to no effect on weight gain in pups. MuAstV RNA was detected in feces from 15 of the 16 dams through postnatal day (PND) 21, and 9 dams were still shedding MuAstV at PND 42...
July 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28719231/biologic-injections-for-osteoarthritis-and-articular-cartilage-damage-can-we-modify-disease
#7
Weilong J Shi, Fotios P Tjoumakaris, Mayan Lendner, Kevin B Freedman
OBJECTIVE: The purpose of the present investigation is to conduct a systematic review of the literature to review the clinical results of platelet rich plasma (PRP) and mesenchymal stem cell treatments (MSC) (biologics) for articular cartilage lesions and osteoarthritis of the knee. METHODS: A search of the PubMed, EMBASE, and Cochrane databases was performed to identify studies involving biologic therapy for osteoarthritis or osteochondral defects. Only Level I-III clinical trials with at least 3-month follow-up were included...
July 28, 2017: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/28699574/a-new-turn-on-fluorometric-detection-method-for-the-determination-of-ag-i-in-some-food-and-water-samples
#8
Şerİfe Saçmaci, Mustafa Saȱmaci, Ahmet Ülgen
A new sensitive and selective turn-on fluorometry procedure for the determination of silver using a laboratory-built fluorometry system is described herein. After synthesis and characterization, a [2-((E)-{[3',6'-bis(ethylamino)-2',7'-dimethyl-3-oxospiro[isoindole-1,9'-xanthen]-2(3H)-yl]imino}methyl)cyclopenta-2,4-dien-1-yl] (cyclopenta-2,4-dien-1-yl)iron (DKMS) fluorescent reagent was used for the first time. Ag(I) was complexed with the new fluorescent reagent, and direct measurements were made using fluorometry without any separation/preconcentration...
July 12, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28690005/pediatric-emergency-department-resource-utilization-among-children-with-primary-care-clinic-contact-in-the-preceding-2-days-a-cross-sectional-study
#9
Christina K Grech, Molly A Laux, Heather L Burrows, Michelle L Macy, Elaine S Pomeranz
OBJECTIVES: To characterize pediatric patient contacts with their primary care clinic in the 2 days preceding a visit to the emergency department (ED) and explore how the type of clinic contact relates to ED resource use. STUDY DESIGN: We conducted a retrospective chart review of 368 pediatric ED visits in the first 7 days of each month, from September 2012 to August 2013. Visits were included if the family contacted their child's general pediatric clinic in the study health system in the 2 days preceding the ED visit...
July 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28686072/expression-of-masculine-identity-in-individuals-with-a-traumatic-brain-injury
#10
Louise C Keegan, Leanne Togher, Macy Murdock, Emma Hendry
PRIMARY OBJECTIVE: This research seeks to examine and describe how four males with a traumatic brain injury (TBI) use language to negotiate their masculine identities. RESEARCH DESIGN: Qualitative research methods were employed with a 'case study' design that allows for a detailed description of the cases, and the interactions examined. METHODS AND PROCEDURES: The tools of inquiry applied included a topic analysis, as well as linguistic analysis methods that incorporated the theory of Systemic Functional Linguistics...
July 7, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28670917/topical-review-maci-as-an-emerging-technology-for-the-treatment-of-talar-osteochondral-lesions
#11
Travis J Dekker, Brandon Erickson, Samuel B Adams, Christopher E Gross
Matrix-induced autologous chondrocyte implantation (MACI) is a viable procedure that can be used as both a primary or revision cartilage regenerative procedure in high-functioning individuals without tibiotalar arthritis. Both short-term and midterm follow-up results demonstrate clinical, radiographic, and functional improvements with high rates of return to full activities. Cost remains a chief concern with the use of this technique, but theoretical improvements in the durability of repair with type II cartilage replacement may offer long-term benefits...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28660822/comparison-of-prognostic-scoring-systems-in-follicular-thyroid-cancer
#12
K W Teo, N K Yuan, W B Tan, R Parameswaran
INTRODUCTION Many studies have addressed the accuracy of prognostic scoring systems in the treatment of differentiated thyroid cancers as a whole but few have addressed this issue in patients with follicular thyroid cancer (FTC) alone. The aim of this study was to establish the accuracy of the various scoring systems in determining the overall and disease free survival of FTC patients in Singapore. METHODS Retrospective review was undertaken of 82 patients with FTC treated at a single tertiary institution between January 2000 and December 2014...
July 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28646474/correlation-between-braf-v600e-mutation-and-clinicopathological-features-in-pediatric-papillary-thyroid-carcinoma
#13
Jiangqiao Geng, Huanmin Wang, Yuanhu Liu, Jun Tai, Yaqiong Jin, Jie Zhang, Lejian He, Libing Fu, Hong Qin, Yingluan Song, Jinzhu Su, Aiying Zhang, Xin Wen, Yongli Guo, Xin Ni
In adults, the presence of the BRAF (V600E) mutation in papillary thyroid cancer (PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF (V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF (V600E) mutation in 48 pediatric patients with PTC, aged 3-13 years...
June 15, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28629026/multistate-proteinous-biomemory-device-based-on-redox-controllable-hapten-cross-linker
#14
Remziye Güzel, Arzu Ersöz, İbrahim Dolak, Rıdvan Say
A multistate biomemory device consisting of cytochrome c (Cyt-c) photosensitively cross-linked by MACys-Ru(bipyr)2-MACys hapten molecules, which have memory effect through a charge transfer mechanism, has been developed. In this study, it has suggested a highly resolute surface-confined switch composed a signal-enhanced electro-active protein (Cyt-c) co-polymerized on the gold substrates that can be controlled by redox property through Ruthenium based cysteine monomer hapten, MACys-Ru(bipyr)2-MACys as an ANADOLUCA photosensitive cross-linker...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28624853/biophysical-stimulation-improves-clinical-results-of-matrix-assisted-autologous-chondrocyte-implantation-in-the-treatment-of-chondral-lesions-of-the-knee
#15
Marco Collarile, Andrea Sambri, Giada Lullini, Matteo Cadossi, Claudio Zorzi
PURPOSE: The purpose of the present study was to evaluate the effects of pulsed electromagnetic fields (PEMFs) on clinical outcome in patients who underwent arthroscopic matrix-assisted autologous chondrocyte implantation (MACI) for chondral lesions of the knee. METHODS: Thirty patients affected by grade III and IV International Cartilage Repair Society chondral lesions of the knee underwent MACI. After surgery, patients were randomly assigned to either experimental group (PEMFs 4 h per day for 60 days) or control group ...
June 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28606223/murine-astrovirus-infection-and-transmission-in-neonatal-cd1-mice
#16
Susan Compton, Carmen J Booth, James D Macy
Murine astrovirus (MuAstV) is a recently identified, widespread infection among laboratory mice. Our goal was to determine the duration of MuAstV infection, susceptibility of pups, and efficacy of soiled-bedding sentinels and environmental monitoring. Eight CD1 dams and their litters of 3-d-old pups and 8 CD1 dams and their litters of 13-d-old mice were inoculatedorally with MuAstV. Neither dams nor offspring demonstrated any clinical signs, and MuAstV had little to no effect on weight gain in pups. MuAstV RNA was detected in feces from 15 of the 16 dams through postnatal day (PND) 21, and 9 dams were still shedding MuAstV at PND 42...
June 12, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28589877/arthroscopic-treatment-of-chondral-defects-in-the-hip-amic-maci-microfragmented-adipose-tissue-transplantation-matt-and-other-options
#17
Eugenio Jannelli, Andrea Fontana
Chondral lesions are currently considered in the hip as a consequence of trauma, osteonecrosis, dysplasia, labral tears, loose bodies, dislocation, previous slipped capital femoral epiphysis and Femoro-Acetabular-Impingement (FAI). The management of chondral lesions is debated and several techniques are described. The physical examination must be carefully performed, followed by radiographs and magnetic resonance imaging (MRI). Differential diagnosis with other pathologies must be considered. Debridement is indicated in patients younger than 50 years with a chondropathy of 1st or 2nd degree...
2017: SICOT-J
https://www.readbyqxmd.com/read/28588884/distinctive-hla-ii-association-with-primary-biliary-cholangitis-on-the-island-of-sardinia
#18
Maria Grazia Clemente, Fulvia Frau, Matilde Bernasconi, Maria Doloretta Macis, Lucia Cicotto, Giampaolo Pilleri, Stefano De Virgiliis, Paolo Castiglia, Patrizia Farci
BACKGROUND: The HLA DRB1*08 allele associated with primary biliary cholangitis (PBC) among Caucasians is of low frequency in the Sardinian population. OBJECTIVE: The aim of our study was to type a cohort of PBC patients from the island of Sardinia for HLA class II antigens. METHODS: Twenty Sardinian patients affected by PBC, 14 with autoimmune hepatitis (AIH) and 89 healthy controls (HCs) were typed for HLA class II alleles by dot-blot analysis...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28587484/seven-year-follow-up-of-matrix-induced-autologous-implantation-in-talus-articular-defects
#19
Christopher Kreulen, Eric Giza, Judie Walton, Martin Sullivan
BACKGROUND: Osteochondral lesions of the talus (OLT) are difficult to treat because of the poor intrinsic healing capability of articular cartilage. Matrix-induced autologous chondrocyte implantation (MACI) has been shown to be a reliable method for treating cartilage lesions that fail to respond to traditional microfracture and debridement. The purpose of this study was to assess 7-year clinical follow-up data of this technique and demonstrate midterm success of this implant. METHODS: A prospective investigation of MACI was performed on 10 patients with OLTs who had failed previous arthroscopic treatment...
June 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28544128/a-pediatric-trial-of-radiation-cetuximab-followed-by-irinotecan-cetuximab-in-newly-diagnosed-diffuse-pontine-gliomas-and-high-grade-astrocytomas-a-pediatric-oncology-experimental-therapeutics-investigators-consortium-study
#20
Margaret E Macy, Mark W Kieran, Susan N Chi, Kenneth J Cohen, Tobey J MacDonald, Amy A Smith, Michael M Etzl, Michele C Kuei, Andrew M Donson, Lia Gore, Jennifer DiRenzo, Tanya M Trippett, Irina Ostrovnaya, Aru Narendran, Nicholas K Foreman, Ira J Dunkel
BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) and high-grade astrocytomas (HGA) continue to have dismal prognoses. The combination of cetuximab and irinotecan was demonstrated to be safe and tolerable in a previous pediatric phase 1 combination study. We developed this phase 2 trial to investigate the safety and efficacy of cetuximab given with radiation therapy followed by adjuvant cetuximab and irinotecan. METHODS: Eligible patients of age 3-21 years had newly diagnosed DIPG or HGA...
May 24, 2017: Pediatric Blood & Cancer
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