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https://www.readbyqxmd.com/read/29662696/bias-in-patient-satisfaction-surveys-a-threat-to-measuring-healthcare-quality
#1
REVIEW
Felipe Dunsch, David K Evans, Mario Macis, Qiao Wang
Patient satisfaction surveys are an increasingly common element of efforts to evaluate the quality of healthcare. Many patient satisfaction surveys in low/middle-income countries frame statements positively and invite patients to agree or disagree, so that positive responses may reflect either true satisfaction or bias induced by the positive framing. In an experiment with more than 2200 patients in Nigeria, we distinguish between actual satisfaction and survey biases. Patients randomly assigned to receive negatively framed statements expressed significantly lower levels of satisfaction (87%) than patients receiving the standard positively framed statements (95%-p<0...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29616842/the-discovery-and-development-of-aclidinium-bromide-for-the-treatment-of-chronic-obstructive-pulmonary-disease
#2
Mario Malerba, Alessandro Radaeli, Giuseppe Santini, Jaymin Morjaria, Nadia Mores, Chiara Mondino, Giuseppe Macis, Paolo Montuschi
Bronchodilators, including long-acting muscarinic receptor antagonists (LAMAs), are a mainstay of the pharmacological treatment of chronic obstructive pulmonary disease (COPD). LAMAs act as bronchodilators principally by antagonizing airway smooth muscle cells M3 muscarinic receptors. Aclidinium bromide is a twice-daily LAMA which was developed to improve on the efficacy and/or safety of previous LAMAs. Area covered: Herein, the authors present the pharmacotherapeutic role of aclidinium in COPD and point out unmet need in this research area...
April 4, 2018: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29611767/impulse-oscillometry-and-nitrogen-washout-test-in-the-assessment-of-small-airway-dysfunction-in-asthma-correlation-with-quantitative-computed-tomography
#3
Leonello Fuso, Giuseppe Macis, Carola Condoluci, Martina Sbarra, Chiara Contu, Emanuele G Conte, Giulia Angeletti, Paolo Montuschi
OBJECTIVE: Small airway dysfunction (SAD) and airway remodeling influence the disease control and progression in asthma. We investigated whether impulse oscillometry (IOS) and single breath nitrogen washout (SBN2 W) could be reliable tests in evaluating SAD and airway remodeling by correlating their data with radiological parameters derived from quantitative chest multidetector computed tomography (MDCT) imaging. METHODS: Lung function tests were performed before and after bronchodilator...
April 3, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29603591/phase-i-study-of-vorinostat-in-combination-with-isotretinoin-in-patients-with-refractory-recurrent-neuroblastoma-a-new-approaches-to-neuroblastoma-therapy-nant-trial
#4
Navin Pinto, Steven G DuBois, Araz Marachelian, Scott J Diede, Agne Taraseviciute, Julia L Glade Bender, Denice Tsao-Wei, Susan G Groshen, Joel M Reid, Daphne A Haas-Kogan, C Patrick Reynolds, Min H Kang, Meredith S Irwin, Margaret E Macy, Judith G Villablanca, Katherine K Matthay, Julie R Park
BACKGROUND: Vorinostat combined with retinoids produces additive antitumor effects in preclinical studies of neuroblastoma. Higher systemic exposures of vorinostat than achieved in pediatric phase I trials with continuous daily dosing are necessary for in vivo increased histone acetylation and cytotoxic activity. We conducted a phase I trial in children with relapsed/refractory neuroblastoma to determine the maximum tolerated dose (MTD) of vorinostat on an interrupted schedule, escalating beyond the previously identified pediatric MTD...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29574124/providing-level-of-match-information-to-perfectly-matched-unrelated-donors-evaluating-acceptability-and-potential-changes-in-donor-availability
#5
Galen E Switzer, Mario Macis, Rachel Fabi, Linda Abress, Dennis Confer, Jessica Bruce, Katie Howe, Sarah Fowler, Mary McNulty, Gabrielle Pastorek, Mary Amanda Dew
Patients with blood-related diseases often cannot identify a matched related donor and must seek donors in unrelated donor registries. These registries face the challenge of ensuring that potential donors are available when contacted. Donor attrition is especially problematic when there is only a single perfectly matched potential donor. One way to improve donor availability might be to present perfectly matched donors (high-priority donors [HPDs]) with more precise information about their match status. This project evaluated the impact of providing such information to HPDs at the National Marrow Donor Program (NMDP)/Be The Match...
March 21, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29570106/the-italian-ministry-of-health-promotes-more-than-300-research-projects-to-improve-cancer-prevention-treatment-and-prognosis
#6
Giovanni Corso, Debora Macis, Bernardo Bonanni, Viviana Galimberti
No abstract text is available yet for this article.
March 21, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29565642/matrix-applied-characterized-autologous-cultured-chondrocytes-versus-microfracture-five-year-follow-up-of-a-prospective-randomized-trial
#7
Mats Brittberg, David Recker, John Ilgenfritz, Daniel B F Saris
BACKGROUND: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured chondrocytes on porcine collagen membrane (MACI) versus microfracture for treating cartilage defects have not yet been reported from any randomized controlled clinical trial. PURPOSE: To examine the clinical efficacy and safety results at 5 years after treatment with MACI and compare these with the efficacy and safety of microfracture treatment for symptomatic cartilage defects of the knee...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29556814/a-cohort-study-on-protocol-based-nurse-led-out-patient-management-of-post-chemotherapy-low-risk-febrile-neutropenia
#8
Fiona Lim Mei Ying, Maria Choy Yin Ping, Macy Tong, Elaine Yim Pik Yan, Tracy Lui Siu Yee, Lam Yuk Ting, Anita Lo Wing Sim, Lui Cheuk Yu, Bosco Lam Hoi Shiu, Ashley Cheng Chi Kin
PURPOSE: International guidelines adopt risk stratification approach to manage patients with low-risk febrile neutropenia patients. We developed this out-patient program using shared-care model with professional input and patient empowerment, so as to reduce patients' psychological burden from hospitalization and to improve the cost-effectiveness of management. METHOD: This is a prospective cohort study to compare the efficacy and safeness of the out-patient program when compared with traditional in-patient care...
March 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29531916/professor-david-ball-prophylactic-cranial-irradiation-pci-benefits-patients-with-sclc
#9
Macy Liu
No abstract text is available yet for this article.
February 2018: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29530026/factors-associated-with-seeking-preventive-dental-care-an-integrative-model-exploration-of-behaviors-in-mexican-immigrants-in-midwest-america
#10
Jonathan T Macy, Elizabeth A S Moser, Adam T Hirsh, Patrick O Monahan, George J Eckert, Gerardo Maupomé
BACKGROUND: Mexican immigrants in the United States suffer from poor oral health. The objective of the current study was to explore the utility of applying theory-based factors associated with seeking preventive dental care in a sample of Mexican American adults. METHODS: Data were collected from a cross-sectional survey of a sample of 157 people of Mexican origin (64% female; age 34 ± 11 years) recruited primarily from church congregations and lay community organizations in Central Indiana...
March 12, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29521193/reporting-maltreatment-to-child-protective-services-in-the-context-of-intimate-partner-violence-research
#11
Cynthia Fraga Rizo, Jennifer O'Brien, Rebecca Macy, Dania Ermentrout, Paul Lanier
Given the overlap between intimate partner violence (IPV) and child maltreatment, IPV-exposed child participants in research might disclose instances of child maltreatment. Such disclosures might require researchers to report the maltreatment to child protective services (CPS). However, the literature provides minimal guidance on how to navigate the complex challenges and ethical dilemmas around reporting in the context of research. To help address this gap and stimulate discussion regarding protocols and policies for reporting child maltreatment, this article presents a CPS reporting protocol developed as part of a community-engaged research project evaluating a parenting intervention for system-involved mothers experiencing IPV...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29486991/characteristics-of-african-american-women-at-high-risk-for-ovarian-cancer-in-the-southeast-results-from-a-gynecologic-cancer-risk-assessment-clinic
#12
David A Barrington, Macie L Champion, Teresa K L Boitano, Christen L Walters-Haygood, Meagan B Farmer, Ronald D Alvarez, Jacob M Estes, Charles A Leath
OBJECTIVES: Describe patient characteristics in African American (AA) women seen for gynecologic cancer related genetic counseling at a large southeastern comprehensive cancer center. METHODS: We reviewed an IRB approved, prospective observational cohort of patients from a Gynecologic Cancer Risk Assessment Clinic. Data evaluated included personal cancer history, family history, frequency of genetic testing, frequency/type of genetic mutations, and frequency of surgical intervention...
February 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29462007/risk-factors-for-recurrence-after-treatment-of-n1b-papillary-thyroid-carcinoma
#13
Sang Hun Lee, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
OBJECTIVES: To examine risk factors for posttreatment recurrence in papillary thyroid carcinoma (PTC) patients with initial presentation of lateral neck metastasis (N1b). SUMMARY OF BACKGROUND DATA: N1b PTC recurs after definitive treatment. METHODS: Study subjects were 437 consecutive PTC patients who underwent total thyroidectomy and therapeutic neck dissection of central and lateral compartments and postoperative radioactive iodine ablation therapy...
February 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29431618/induction-chemotherapy-plus-concurrent-chemoradiotherapy-in-endemic-nasopharyngeal-carcinoma-individual-patient-data-pooled-analysis-of-four-randomized-trials
#14
Yu-Pei Chen, Ling-Long Tang, Qi Yang, Sharon-Shuxian Poh, Edwin P Hui, Anthony Tc Chan, Whee Sze Ong, Tan Terence, Joseph T Wee, Wen-Fei Li, Lei Chen, Brigette B Y Ma, Macy Tong, Sze Huey Tan, Shie-Lee Cheah, Kam-Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Ying Guo, Ai-Hua Lin, Ying Sun, Minghuang Hong, Sumei Cao, Mingyuan Chen, Jun Ma
PURPOSE: Due to uneven geographical distribution and small number of randomized trials available, the value of additional induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) in nasopharyngeal carcinoma (NPC) remains controversial. This study performed an individual patient data (IPD) pooled analysis to better assess the precise role of IC+CCRT in locoregionally advanced NPC. EXPERIMENTAL DESIGN: Four randomized trials in endemic areas were identified, representing 1,193 patients; updated IPD were obtained...
February 5, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29429373/long-term-clinical-and-mri-results-of-matrix-assisted-autologous-chondrocyte-implantation-for-articular-cartilage-defects-of-the-knee
#15
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Objective To evaluate the long-term clinical and radiological outcome of matrix-assisted autologous chondrocyte implantation (mACI) for articular cartilage defects in the knee joint. Design Clinical evaluation was assessed in 21 patients with full-thickness cartilage defects, International Cartilage Repair Society (ICRS) grade IV. Clinical scoring was performed preoperatively and 12 years after transplantation using the International Knee Documentation Committee (IKDC) score, the Lysholm score, the Knee injury and Osteoarthritis Outcome Score (KOOS), and the Noyes sports activity rating scale...
February 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29395185/variation-in-part-time-work-among-pediatric-subspecialties
#16
Gary L Freed, Debra M Boyer, Kenton D Van, Michelle L Macy, Julie McCormick, Laurel K Leslie
OBJECTIVE: To assess the part-time workforce and average hours worked per week among pediatric subspecialists in the 15 medical subspecialties certified by the American Board of Pediatrics. STUDY DESIGN: We examined data from pediatric subspecialists who enrolled in Maintenance of Certification with the American Board of Pediatrics from 2009 to 2015. Data were collected via an online survey. Providers indicated whether they worked full time or part time and estimated the average number of hours worked per week in clinical, research, education, and administrative tasks, excluding time on call...
January 29, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29393745/analysis-of-platinum-content-in-biodegradable-carboplatin-impregnated-beads-and-retrospective-assessment-of-tolerability-for-intralesional-use-of-the-beads-in-dogs-following-excision-of-subcutaneous-sarcomas-29-cases-2011-2014
#17
Theresa A Hess, Macy E Drinkhouse, Joshua D Prey, Jonathan M Miller, Arthur A Fettig, Carol A Carberry, Stephen H Brenn, Dennis B Bailey
OBJECTIVE To evaluate platinum content in biodegradable carboplatin-impregnated beads and retrospectively assess tolerability and outcome data for dogs treated by intralesional placement of such beads following surgical excision of subcutaneous sarcomas. DESIGN Evaluation study and retrospective case series. SAMPLE 9 carboplatin-impregnated beads and 29 client-owned dogs. PROCEDURES Platinum content in 9 carboplatin-impregnated beads from 3 lots was measured by spectrophotometry, and calculated carboplatin content was compared with the labeled content...
February 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29387645/clinical-evidence-of-traditional-vs-fast-track-recovery-methodologies-after-total-arthroplasty-for-osteoarthritic-knee-treatment-a-retrospective-observational-study
#18
Sergio Castorina, Claudia Guglielmino, Paola Castrogiovanni, Marta Anna Szychlinska, Francesco Ioppolo, Paolo Massimino, Pietro Leonardi, Christian Maci, Maurizio Iannuzzi, Angelo Di Giunta, Giuseppe Musumeci
Background: During the last years, programs to enhance postoperative recovery and decrease morbidity after total knee arthroplasty, have been developed across a variety of surgical procedures and referred to as "Fast-Track Surgery". In this study we aimed to find some answers in the management of osteoarthritic patients subjected to total knee arthroplasty, by using the Fast-Track methodology. To this purpose we evaluated parameters such as early mobilization of patients, better pain management, bleeding, possible complications, reduced hospitalization time, an overall improved recovery and patient satisfaction...
July 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29377930/facebook-as-communication-support-for-persons-with-potential-mild-acquired-cognitive-impairment-a-content-and-social-network-analysis-study
#19
Aboozar Eghdam, Ulrika Hamidi, Aniko Bartfai, Sabine Koch
INTRODUCTION: Social media has the potential to increase social participation and support for the well-being of individuals with chronic medical conditions. To date, Facebook is the most popular social medium for different types of communication. However, there is a lack of knowledge about the potential use of Facebook as a means of communication for persons with potential Mild Acquired Cognitive Impairment (MACI), a non-progressive mild cognitive impairment after an acquired brain injury...
2018: PloS One
https://www.readbyqxmd.com/read/29353295/spanish-version-validation-of-the-marihuana-motives-measure-in-a-drug-consuming-adolescent-sample
#20
Josep Matali Costa, J Simons, M Pardo, M Lleras, A Pérez, O Andión
INTRODUCTION: Cannabis is the illicit drug mostly widely consumed by adolescents in Spain. The understanding of consumption motives is an important factor for intervention. In Spain, there are no available instruments for their evaluation, hence, the goal of this paper is to study the psychometric properties of the Marihuana Motives Measure (MMM) in a sample of adolescent consumers. MATERIAL AND METHOD: Firstly, translation and back-translation was performed. A total of 228 adolescent consumers of cannabis were evaluated...
January 15, 2018: Adicciones
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