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Microencapsulation

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https://www.readbyqxmd.com/read/29341917/a-novel-method-for-the-production-of-core-shell-microparticles-by-inverse-gelation-optimized-with-artificial-intelligent-tools
#1
Rosalia Rodríguez-Dorado, Mariana Landín, Ayça Altai, Paola Russo, Rita P Aquino, Pasquale Del Gaudio
Numerous studies have been focused on hydrophobic compounds encapsulation as oils. In fact, oils can provide numerous health benefits as synergic ingredient combined with other hydrophobic active ingredients. However, stable microparticles for pharmaceutical purposes are difficult to achieve when commonly techniques are used. In this work, sunflower oil was encapsulated in calcium-alginate capsules by prilling technique in co-axial configuration. Core-shell beads were produced by inverse gelation directly at the nozzle using w/o emulsion containing aqueous calcium chloride solution in sunflower oil pumped through the inner nozzle while an aqueous alginate solution, coming out from the annular nozzle, produced the bead shell...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29339146/microspheres-as-intraocular-therapeutic-tools-in-chronic-diseases-of-the-optic-nerve-and-retina
#2
Irene Bravo-Osuna, Vanessa Andrés-Guerrero, Alicia Arranz-Romera, Sergio Esteban-Pérez, Irene T Molina-Martínez, Rocío Herrero-Vanrell
Pathologies affecting the optic nerve and the retina are one of the major causes of blindness. These diseases include age-related macular degeneration (AMD), diabetic Retinopathy (DR) and glaucoma, among others. Also, there are genetic disorders that affect the retina causing visual impairment. The prevalence of neurodegenerative diseases of the posterior segment are increased as most of them are related with the elderly. Even with the access to different treatments, there are some challenges in managing patients suffering retinal diseases...
January 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29337670/sustained-release-biodegradable-solid-lipid-microparticles-formulation-evaluation-and-statistical-optimization-by-response-surface-methodology
#3
Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb, Nazar Abbas
For preparing nebivolol loaded solid lipid microparticles (SLMs) by the solvent evaporation microencapsulation process from carnauba wax and glyceryl monostearate, central composite design was used to study the impact of independent variables on yield (Y1), entrapment efficiency (Y2) and drug release (Y3). SLMs having a 10-40 μm size range, with good rheological behavior and spherical smooth surfaces, were produced. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffractometry pointed to compatibility between formulation components and the zeta-potential study confirmed better stability due to the presence of negative charge (-20 to -40 mV)...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29329810/facile-microencapsulation-of-olive-oil-in-porous-starch-granules-fabrication-characterization-and-oxidative-stability
#4
Miao Lei, Fang-Cheng Jiang, Jie Cai, Si Hu, Rui Zhou, Gang Liu, Yue-Hui Wang, Hai-Bo Wang, Jing-Ren He, Xin-Gao Xiong
In this study, starch with porous structures derived from purple sweet potato was prepared and used as a food-grade polymer for the microencapsulation of olive oil. The optimal reaction conditions for preparing porous starch were determined to improve its adsorption capacity as effective microcapsule-wall materials. Olive oil was then impregnated in microspheres, and loading ratio was optimized by investigating the restrictive factors, including the mass ratio of olive oil to porous starch, as well as the embedding temperature and time...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29313296/the-biological-effects-of-the-hypolipidaemic-drug-probucol-microcapsules-fed-daily-for-4%C3%A2-weeks-to-an-insulin-resistant-mouse-model-potential-hypoglycaemic-and-anti-inflammatory-effects
#5
Armin Mooranian, Rebecca Negrulj, Ryu Takechi, John Mamo, Hesham Al-Sallami, Hani Al-Salami
Probucol (PB) is an hypolipidaemic drug with potential antidiabetic effects. We showed recently using in vitro studies that when PB was incorporated with stabilising lipophilic bile acids and microencapsulated using the polymer sodium alginate, the microcapsules showed good stability but poor and irregular PB release. This suggests that PB microcapsules may exhibit better release profile and hence better absorption, if more hydrophilic bile acids were used, such as ursodeoxycholic acid (UDCA). Accordingly, this study aimed to produce PB-UDCA microcapsules and examine PB absorption and antidiabetic effects in our mouse-model of insulin-resistance and diabetes (fed high-fat diet; HFD)...
January 8, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29291100/microencapsulated-diets-to-improve-bivalve-shellfish-aquaculture
#6
David Willer, David C Aldridge
Aquaculture is the fastest growing food sector and feeds over 3 billion people. Bivalve shellfish aquaculture makes up 25% of global aquaculture production and is worth annually US$19 billion, but continued growth is currently limited by suboptimal diets and limited tools for disease control. New advances in microencapsulation technology could provide an effective way to overcome these biological limitations. This study demonstrated that a new formulation of microencapsulated diet known as BioBullets could be ingested by a commercially farmed bivalve; the blue mussel Mytilus edulis...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29287450/functionalization-of-yogurts-with-agaricus-bisporus-extracts-encapsulated-in-spray-dried-maltodextrin-crosslinked-with-citric-acid
#7
Cristhian R L Francisco, Sandrina A Heleno, Isabel P M Fernandes, João C M Barreira, Ricardo C Calhelha, Lillian Barros, Odinei Hess Gonçalves, Isabel C F R Ferreira, Maria Filomena Barreiro
Mushroom extracts contain bioactive compounds potentially useful to functionalize foodstuffs. Herein, alcoholic extracts of Agaricus bisporus were studied for their bioactivity and viability as functional ingredients in a food product with high water content (yogurt). Extracts were microencapsulated (to improve their stability and hydrophilicity) by spray-drying, using maltodextrin crosslinked with citric acid as encapsulating material. The effect of thermal treatment (after atomization) on crosslinking and bioactivity of microspheres was tested...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29279112/microencapsulation-by-pectin-for-multi-components-carriers-bearing-both-hydrophobic-and-hydrophilic-active-agents
#8
Juran Noh, Jin Kim, Jin Sic Kim, Young Soo Chung, Suk Tai Chang, Juhyun Park
Oil/water microencapsulation by microfluidic systems has been a prominent delivery method to prepare functional microcapsules in the food, cosmetic, and pharmaceutical industries because it is an easy way to control the shape and size of structures and functionalities. We prepared biocompatible and multi-component microcapsules using the precipitation and ionic crosslinking of pectin in a poor solubility environment and with multivalent cations, respectively. When the aqueous solution (including calcium ions and ethanol) in a sheath flow met the flow of a pectin aqueous solution containing oil droplets, ethanol-gelation and ionic cross-linking occurred, enclosing the inner oil phase droplets by solidified pectin shells...
February 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29276781/recent-progress-in-the-use-and-tracking-of-transplanted-islets-as-a-personalized-treatment-for-type-1-diabetes
#9
Genaro A Paredes-Juarez, Paul de Vos, Jeff W M Bulte
Introduction: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the pancreas produces insufficient amounts of insulin. T1DM patients require exogenous sources of insulin to maintain euglycemia. Transplantation of naked or microencapsulated pancreatic islets represents an alternative paradigm to obtain an autonomous regulation of blood glucose levels in a controlled and personalized fashion. However, once transplanted, the fate of these personalized cellular therapeutics is largely unknown, justifying the development of non-invasive tracking techniques...
2017: Expert Review of Precision Medicine and Drug Development
https://www.readbyqxmd.com/read/29276661/microencapsulation-of-reuterin-to-enhance-long-term-efficacy-against-food-borne-pathogen-listeria-monocytogenes
#10
Santosh Kumar Mishra, R K Malik, Harsh Panwar, Amit Kumar Barui
The aim of this study was to microencapsulate the reuterin produced by Lactobacillus reuteri BPL-36 strain for its long-term efficacy against food-borne pathogen Listeria monocytogenes. Lactobacillus reuteri BPL-36 strain previously isolated from a human infant fecal sample in lab was selected for the present study based on its ability to produce reuterin. The organism displayed a broad-spectrum antimicrobial activity. Reuterin concentration of 89.63 mM was obtained in the MRS-glycerol medium after 16 h incubation at 37 °C...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29250977/microencapsulated-macrophages-releases-conditioned-medium-able-to-prevent-epithelial-to-mesenchymal-transition
#11
Anna Sola, Laura Saenz Del Burgo, Jesús Ciriza, Rosa Maria Hernandez, Gorka Orive, Jorge Martin Cordero, Priscila Calle, Jose Luis Pedraz, Georgina Hotter
Epithelial to mesenchymal transition (EMT) has emerged as a key process in the development of renal fibrosis. In fact, EMT-derived fibroblasts contribute to the progression of chronic renal disease. In addition, anti-inflammatory M2 macrophages have exhibited a great influence on renal fibrosis. However, because of the high impact that the inputs of different environmental cytokines have on their phenotype, macrophages can easily lose this property. We aim to known if microencapsulated macrophages on M2-inducing alginate matrices could preserve macrophage phenotype and thus release factors able to act on epithelial cells to prevent the epithelial differentiation towards mesenchymal cells...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29229246/microencapsulation-of-saffron-anthocyanins-using-%C3%AE-glucan-and-%C3%AE-cyclodextrin-nutraceutical-morphological-structural-and-the-release-behavior-of-capsules-during-in-vitro-digestion
#12
Mudasir Ahmad, Bisma Ashraf, Asir Gani, Adil Gani
In the present study, the saffron anthocyanins were encapsulated in β-glucan and β-cyclodextrin by spray drying technique to achieve their stability under adverse gastro-enviromental conditions. The microcapsules were subjected to simulated gastric conditions and release behavior of monomeric anthocyanins, antioxidants and phenols were studied. The structural properties of microcapsules were analyzed by SEM and ATR-FTIR spectroscopy. The particle size distribution, density, color, encapsulation efficiency and powder yield of samples were also evaluated...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29222028/sodium-butyrate-enhanced-physical-barrier-function-referring-to-nrf2-jnk-and-mlck-signaling-pathways-in-the-intestine-of-young-grass-carp-ctenopharyngodon-idella
#13
Pei Wu, Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Fei Xie, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Juan Yang, Yong-An Zhang, He-Qun Shi, Lin Feng
This study evaluated the effect of dietary sodium butyrate (SB) supplementation on the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella). The fish were fed one powdery sodium butyrate (PSB) diet (1000.0 mg kg-1 diet) and five graded levels of microencapsulated sodium butyrate (MSB) diets: 0.0 (control), 500.0, 1000.0, 1500.0 and 2000.0 mg kg-1 diet for 60 days. Subsequently, a challenge test was conducted by injection of Aeromonas hydrophila to explore the effect of SB supplementation on intestinal physical barrier function and the potential mechanisms in fish...
December 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29215800/microencapsulation-for-the-cell-therapy-of-type-1-diabetes-mellitus-the-interplay-between-common-beliefs-prejudices-and-real-progress
#14
EDITORIAL
Riccardo Calafiore
When Anthony Sun (1) showed, for the first time in 1980, that intraperitoneal graft of allogeneic rat pancreatic islet containing alginate-poly-L-lysine microcapsules, reversed hyperglycemia in not immunosuppressed diabetic rats, a new era for the cell therapy of diabetes had started. As a unique and unmatched result, years later, Sun replied success in diabetic primates, that upon intraperitoneal transplant of microencapsulated porcine islets, showed long-term remission of hyperglycemia. However, at that time, the international academic and scientific community greeted with skepticism such a revolutionary approach...
December 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29215799/comparison-of-prestoblue%C3%A2-and-plating-method-to-evaluate-antimicrobial-activity-of-ascorbic-acid-boric-acid-and-curcumin-in-an-in-vitro-gastrointestinal-model
#15
Daniel Hernandez-Patlan, Bruno Solis-Cruz, Abraham Méndez-Albores, Juan D Latorre, Xochitl Hernandez-Velasco, Guillermo Tellez, Raquel López-Arellano
AIMS: To compare the conventional plating method versus a fluorometric method using PrestoBlue® as a dye by determining the antimicrobial activity of two organic acids and curcumin against Salmonella Enteritidis in an avian in vitro digestion model that simulates the crop, proventriculus and intestine. METHODS AND RESULTS: A concentration of 108 cfu ml-1 of S. Enteritidis was exposed to groups with different rates of ascorbic acid, boric acid and curcumin. Significant differences were observed when the means of the treatments were compared with the controls in the compartments that simulate the crop and intestine (P < 0...
December 7, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29214609/soy-protein-microparticles-for-enhanced-oral-ibuprofen-delivery-preparation-characterization-and-in-vitro-release-evaluation
#16
Maria Antonieta Anaya Castro, Isabelle Alric, Fabien Brouillet, Jérôme Peydecastaing, Sophie Girod Fullana, Vanessa Durrieu
The objective of this work was to evaluate soy protein isolate (SPI) and acylated soy protein (SPA) as spray-drying encapsulation carriers for oral pharmaceutical applications. SPI acylation was performed by the Schotten-Baumann reaction. SPA, with an acylation rate of 41%, displayed a decrease in solubility in acidic conditions, whereas its solubility was unaffected by basic conditions. The drug encapsulation capacities of both SPI and SPA were tested with ibuprofen (IBU) as a model poorly soluble drug. IBU-SPI and IBU-SPA particles were obtained by spray-drying under eco-friendly conditions...
December 6, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29212824/targeted-microbiome-intervention-by-microencapsulated-delayed-release-niacin-beneficially-affects-insulin-sensitivity-in-humans
#17
Daniela Fangmann, Eva-Maria Theismann, Kathrin Türk, Dominik M Schulte, Isabelle Relling, Katharina Hartmann, Julia K Keppler, Jörg-Rainer Knipp, Ateequr Rehman, Femke-Anouska Heinsen, Andre Franke, Lennart Lenk, Sandra Freitag-Wolf, Esther Appel, Stanislav Gorb, Charles Brenner, Dirk Seegert, Georg H Waetzig, Philip Rosenstiel, Stefan Schreiber, Karin Schwarz, Matthias Laudes
OBJECTIVE: Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially affect the host-microbiome interaction in rodent models. RESEARCH DESIGN AND METHODS: We characterized more than 500 human subjects with different metabolic phenotypes regarding their niacin (nicotinic acid [NA] and nicotinamide [NAM]) status and their gut microbiome. In addition, NA and NAM delayed-release microcapsules were engineered and examined in vitro and in vivo in two human intervention studies (bioavailability study and proof-of-concept/safety study)...
December 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29208500/effect-of-microencapsulated-probiotic-bacillus-vireti-01-polysaccharide-extract-of-gracilaria-folifera-with-alginate-chitosan-on-immunity-antioxidant-activity-and-disease-resistance-of-macrobrachium-rosenbergii-against-aeromonas-hydrophila-infection
#18
S Vidhya Hindu, S Thanigaivel, S Vijayakumar, Natarajan Chandrasekaran, Amitava Mukherjee, John Thomas
Polysaccharide from red seaweed Gracilaria folifera has an interesting functional property of antioxidant activity and prebiotic effect. A feeding trial experiment was directed to examine the effect of probiotic bacteria Bacillus vireti 01 microencapsulated with G. folifera polysaccharide against freshwater prawn M. rosenbergii. Three different feeding trials were conducted for 15 days. The first group contained prawns fed with commercial diet. The second group was comprised of Aeromonas hydrophila challenged prawns fed with commercial feed...
December 2, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29206479/microencapsulation-of-esterified-krill-oil-using-complex-coacervation
#19
Selim Kermasha, Sarya Aziz, Jagpreet Gill, Ronald Neufeld
The microencapsulation of the esterified krill oil (EKO), obtained from the transesterification of krill oil (KO) with 3,4-dihydroxyphenylacetic acid (DHPA), via complex coacervation, was investigated. The experimental findings showed that the DHPA and phenolic lipids (PLs) in the EKO affected the stability of the gelatin (GE)-EKO emulsion. To improve its stability, the effects of varying the pH of GE and the use of two emulsification devices, including the homogenizer and ultrasonic liquid processor were investigated, where the ultrasonic liquid processor was found to be a relatively more appropriate emulsification device...
December 5, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29200966/microencapsulation-of-low-passage-poorly-differentiated-human-mucoepidermoid-carcinoma-cells-by-alginate-microcapsules-in-vitro-profiling-of-angiogenesis-related-molecules
#20
Sen Yang, Li-Juan Guo
Background: Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly differentiated cancer cells of high-grade MEC, contributes to tumor growth and metastasis. Therefore, elucidating molecular mechanisms underlying the pro-angiogenic ability of poorly differentiated MEC cells is critical for the understanding of high-grade MEC progression. It is well known that three-dimensional (3D) cell culture, in contrast with conventional two-dimensional (2D) culture, provides a better approach to in vitro recapitulation of in vivo characteristics of cancer cells and their surrounding microenvironment...
2017: Cancer Cell International
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