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Microencapsulation

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https://www.readbyqxmd.com/read/27911415/extraction-of-plant-based-capsules-for-microencapsulation-applications
#1
Michael G Potroz, Raghavendra C Mundargi, Jae Hyeon Park, Ee-Lin Tan, Nam-Joon Cho
Microcapsules derived from plant-based spores or pollen provide a robust platform for a diverse range of microencapsulation applications. Sporopollenin exine capsules (SECs) are obtained when spores or pollen are processed so as to remove the internal sporoplasmic contents. The resulting hollow microcapsules exhibit a high degree of micromeritic uniformity and retain intricate microstructural features related to the particular plant species. Herein, we demonstrate a streamlined process for the production of SECs from Lycopodium clavatum spores and for the loading of hydrophilic compounds into these SECs...
November 9, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27910742/review-article-fabricated-microparticles-an-innovative-method-to-minimize-the-side-effects-of-nsaids-in-arthritis
#2
Shaivad Shabee Hulhasan Abadi, Afrasim Moin, Gangadharappa Hosahalli Veerabhadrappa
Microparticles are polymeric bodies ranging 1-1000 µm that constitute a variety of forms such as microcapsules, microspheres, microcages, microshells, microrods, biosensors microparticles, radiolabeled microparticles, and so forth. This review focuses on general microparticles, mainly microcapsules and microspheres. Nonsteriodal anti-inflammatory drugs (NSAIDs) are one of the mostcommonly prescribed medications in the world. Most of the NSAIDs available have severe side effects. With increased awareness of NSAID-induced gastrointestinal (GI) side effects, safety has become a priority in treatment of arthritis and other inflammatory diseases with NSAIDs...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27910739/overview-on-therapeutic-applications-of-microparticulate-drug-delivery-systems
#3
Swarna Bale, Amit Khurana, A Shiva Shankar Reddy, Mandip Singh, Chandraiah Godugu
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27904393/the-production-of-synbiotic-bread-by-microencapsulation
#4
Mojan Seyedain-Ardabili, Anousheh Sharifan, Babak Ghiassi Tarzi
Bread is a global staple food. Despite attempts to develop functional breads containing viable microorganisms, this has not been done yet because of the high temperature during baking. The aim of this study is to obtain synbiotic bread, hence hamburger bun and white pan bread were selected. Lactobacillus acidophilus LA-5 and L. casei 431 were encapsulated with calcium alginate and Hi-maize resistant starch via emulsion technique and coated with chitosan. The morphology and size of microcapsules were measured by scanning electron microscopy and particle size analyser...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27900876/effects-of-production-methods-and-protective-ingredients-on-the-viability-of-probiotic-lactobacillus-rhamnosus-r0011-in-air-dried-alginate-beads
#5
Claude P Champagne, Yves Raymond, Yves Arcand
The goal of this study was to use a microencapsulation technology to prepare air-dried concentrated cultures of Lactobacillus rhamnosus R0011. The cultures were microencapsulated in alginate beads, which were added to a growth medium to allow cell multiplication inside the matrix; the beads were recovered, dipped in protective solutions, and air-dried. The effects of fermentation technology and of the composition of the protective solutions on subsequent survival during air-drying were examined. The cells prepared under a constant pH of 6...
August 26, 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27868414/-effect-of-shift-rotation-culture-on-formation-and-activity-of-encapsulated-hepatocytes-aggregates
#6
Yanshan Chen, Chengbo Yu, Hongcui Cao, Lanjuan Li
Objective: To observe the effect of uniform and shift rotation culture on the formation and activity of the alginate-chitosan (AC) microencapsulated HepLL immortalized human hepatocytes and HepG2 cells aggregates. Methods: AC microcapsulated HepG2 and HepLL cells were randomly divided into two groups. Each group was divided into 3 subgroups according to uniform and shift rotation culture.The size and number of aggregates were observed and measured under laser confocal microscopy and inverted microscope dynamically...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27867770/soymilk-residue-okara-as-a-natural-immobilization-carrier-for-lactobacillus-plantarum-cells-enhances-soymilk-fermentation-glucosidic-isoflavone-bioconversion-and-cell-survival-under-simulated-gastric-and-intestinal-conditions
#7
Xia Xiudong, Wang Ying, Liu Xiaoli, Li Ying, Zhou Jianzhong
Cell immobilization is an alternative to microencapsulation for the maintenance of cells in a liquid medium. However, artificial immobilization carriers are expensive and pose a high safety risk. Okara, a food-grade byproduct from soymilk production, is rich in prebiotics. Lactobacilli could provide health enhancing effects to the host. This study aimed to evaluate the potential of okara as a natural immobilizer for L. plantarum 70810 cells. The study also aimed to evaluate the effects of okara-immobilized L...
2016: PeerJ
https://www.readbyqxmd.com/read/27864069/microencapsulated-sln-an-innovative-strategy-for-pulmonary-protein-delivery
#8
Diana P Gaspar, Carmen Serra, Paulo R Lino, Lídia Gonçalves, Pablo Taboada, Carmen Remuñán-López, António J Almeida
Associating protein with nanoparticles is an interesting strategy to improve their bioavailability and biological activity. Solid lipid nanoparticles (SLN) have been sought as carriers for therapeutic proteins transport to the lung epithelium. Nevertheless, because of their low inertia, nanoparticles intended for pulmonary application usually escape from lung deposition. To overcome this problem, the production of spray-dried powders containing nanoparticles has been recently reported. Herein we developed new hybrid microencapsulated SLN for pulmonary administration, containing a model protein (papain, PAP)...
November 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27862940/chitosan-nhac-plga-microsphere-vehicle-for-sustained-release-of-rhbmp-2-and-its-derived-synthetic-oligopeptide-for-bone-regeneration
#9
Yanhui Ji, Mingbo Wang, Weiqiang Liu, Changsheng Chen, Wei Cui, Tingfang Sun, Qingling Feng, Xiaodong Guo
Both of the osteogenic factor and the suitable delivery system in bone tissue engineering are essential for bone regeneration. In this study, we manufactured two kinds of composite vehicles for sustained release of rhBMP-2 and its derived synthetic oligopeptide (Peptide-24, abbreviated as P24) for osteogenesis and bone defect repair. The composite vehicle was based on cross-linked chitosan, nano-hydroxyapatite/collagen (nHAC), and poly (lactide-co-glycolide) acid microsphere. The physicochemical properties of the composite vehicles (abbreviated as CS/nHAC/PLGA-MS) were investigated...
November 10, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27855936/microencapsulation-of-palm-oil-by-complex-coacervation-for-application-in-food-systems
#10
Josiane K Rutz, Caroline D Borges, Rui C Zambiazi, Michele M Crizel-Cardozo, Luiza S Kuck, Caciano P Z Noreña
This study aimed at microencapsulating palm oil, containing high carotenoid content, with chitosan/xanthan and chitosan/pectin, using the complex coacervation method, followed by atomization and lyophilization. The DSC technique was used to confirm the encapsulation. The atomized microparticles had spherical shape and irregular size, and the lyophilized microparticles had irregular shape and size. Lyophilization resulted in lower carotenoids losses, and higher yield and encapsulation efficiency. In addition, the release profile in both water and gastrointestinal fluid was satisfactory...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27844282/morphological-changes-in-a-severe-model-of-parkinson-s-disease-and-its-suitability-to-test-the-therapeutic-effects-of-microencapsulated-neurotrophic-factors
#11
C Requejo, J A Ruiz-Ortega, H Bengoetxea, A García-Blanco, E Herrán, A Aristieta, M Igartua, J L Pedraz, L Ugedo, R M Hernández, J V Lafuente
The unilateral 6-hydroxydopamine (6-OHDA) lesion of medial forebrain bundle (MFB) in rats affords us to study the advanced stages of Parkinson's disease (PD). Numerous evidences suggest synergic effects when various neurotrophic factors are administered in experimental models of PD. The aim of the present work was to assess the morphological changes along the rostro-caudal axis of caudo-putamen complex and substantia nigra (SN) in the referred model in order to test the suitability of a severe model to evaluate new neurorestorative therapies...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27830559/microencapsulation-of-hepatocytes-and-mesenchymal-stem-cells-for-therapeutic-applications
#12
Raphael P H Meier, Elisa Montanari, Philippe Morel, Joël Pimenta, Henk-Jan Schuurman, Christine Wandrey, Sandrine Gerber-Lemaire, Redouan Mahou, Leo H Bühler
Encapsulated hepatocyte transplantation and encapsulated mesenchymal stem cell transplantation are newly developed potential treatments for acute and chronic liver diseases, respectively. Cells are microencapsulated in biocompatible semipermeable alginate-based hydrogels. Microspheres protect cells against antibodies and immune cells, while allowing nutrients, small/medium size proteins and drugs to diffuse inside and outside the polymer matrix. Microencapsulated cells are assessed in vitro and designed for experimental transplantation and for future clinical applications...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27829482/microencapsulated-bitter-compounds-from-gentiana-lutea-reduce-daily-energy-intakes-in-humans
#13
Ilario Mennella, Vincenzo Fogliano, Rosalia Ferracane, Marco Arlorio, Franco Pattarino, Paola Vitaglione
Mounting evidence showed that bitter-tasting compounds modulate eating behaviour through bitter taste receptors in the gastrointestinal tract. This study aimed at evaluating the influence of microencapsulated bitter compounds on human appetite and energy intakes. A microencapsulated bitter ingredient (EBI) with a core of bitter Gentiana lutea root extract and a coating of ethylcellulose-stearate was developed and included in a vanilla microencapsulated bitter ingredient-enriched pudding (EBIP). The coating masked bitterness in the mouth, allowing the release of bitter secoiridoids in the gastrointestinal tract...
November 10, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27829016/delivery-of-human-adipose-stem-cells-spheroids-into-lockyballs
#14
Karina R Silva, Rodrigo A Rezende, Frederico D A S Pereira, Peter Gruber, Mellannie P Stuart, Aleksandr Ovsianikov, Ken Brakke, Vladimir Kasyanov, Jorge V L da Silva, José M Granjeiro, Leandra S Baptista, Vladimir Mironov
Adipose stem cells (ASCs) spheroids show enhanced regenerative effects compared to single cells. Also, spheroids have been recently introduced as building blocks in directed self-assembly strategy. Recent efforts aim to improve long-term cell retention and integration by the use of microencapsulation delivery systems that can rapidly integrate in the implantation site. Interlockable solid synthetic microscaffolds, so called lockyballs, were recently designed with hooks and loops to enhance cell retention and integration at the implantation site as well as to support spheroids aggregation after transplantation...
2016: PloS One
https://www.readbyqxmd.com/read/27819337/the-role-of-gibberellins-in-improving-the-resistance-of-tebuconazole-coated-maize-seeds-to-chilling-stress-by-microencapsulation
#15
Lijuan Yang, Daibin Yang, Xiaojing Yan, Li Cui, Zhenying Wang, Huizhu Yuan
Chilling stress during germination often causes severe injury. In the present study, maize seed germination and shoot growth under chilling stress were negatively correlated with the dose of tebuconazole in an exponential manner as predicted by the model Y = A + B × e((-x/k)). Microencapsulation was an effective means of eliminating potential phytotoxic risk. The gibberellins (GAs) contents were higher after microencapsulation treatment than after conventional treatment when the dose of tebuconazole was higher than 0...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819009/chitin-and-chitosan-production-and-application-of-versatile-biomedical-nanomaterials
#16
Daniel Elieh-Ali-Komi, Michael R Hamblin
Chitin is the most abundant aminopolysaccharide polymer occurring in nature, and is the building material that gives strength to the exoskeletons of crustaceans, insects, and the cell walls of fungi. Through enzymatic or chemical deacetylation, chitin can be converted to its most well-known derivative, chitosan. The main natural sources of chitin are shrimp and crab shells, which are an abundant byproduct of the food-processing industry, that provides large quantities of this biopolymer to be used in biomedical applications...
March 2016: International Journal of Advanced Research
https://www.readbyqxmd.com/read/27808253/remote-in-vivo-stress-assessment-of-aquatic-animals-with-microencapsulated-biomarkers-for-environmental-monitoring
#17
Anton Gurkov, Ekaterina Shchapova, Daria Bedulina, Boris Baduev, Ekaterina Borvinskaya, Igor Meglinski, Maxim Timofeyev
Remote in vivo scanning of physiological parameters is a major trend in the development of new tools for the fields of medicine and animal physiology. For this purpose, a variety of implantable optical micro- and nanosensors have been designed for potential medical applications. At the same time, the important area of environmental sciences has been neglected in the development of techniques for remote physiological measurements. In the field of environmental monitoring and related research, there is a constant demand for new effective and quick techniques for the stress assessment of aquatic animals, and the development of proper methods for remote physiological measurements in vivo may significantly increase the precision and throughput of analyses in this field...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789158/essential-oils-as-ecofriendly-biopesticides-challenges-and-constraints
#18
REVIEW
Roman Pavela, Giovanni Benelli
Recently, a growing number of plant essential oils (EOs) have been tested against a wide range of arthropod pests with promising results. EOs showed high effectiveness, multiple mechanisms of action, low toxicity on non-target vertebrates and potential for the use of byproducts as reducing and stabilizing agents for the synthesis of nanopesticides. However, the number of commercial biopesticides based on EOs remains low. We analyze the main strengths and weaknesses arising from the use of EO-based biopesticides...
December 2016: Trends in Plant Science
https://www.readbyqxmd.com/read/27765212/structural-and-oxidative-stabilization-of-spray-dried-fish-oil-microencapsulates-with-gum-arabic-and-sage-polyphenols-characterization-and-release-kinetics
#19
P K Binsi, Natasha Nayak, P C Sarkar, A Jeyakumari, P Muhamed Ashraf, George Ninan, C N Ravishankar
The synergistic efficacy of gum arabic and sage polyphenols in stabilising capsule wall and protecting fish oil encapsulates from heat induced disruption and oxidative deterioration during spray drying was assessed. The emulsions prepared with sodium caseinate as wall polymer, gum arabic as wall co-polymer and sage extract as wall stabiliser was spray dried using a single fluid nozzle. Fish oil encapsulates stabilised with gum arabic and sage extract (SOE) exhibited significantly higher encapsulation efficiency compared to encapsulates containing gum arabic alone (FOE)...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27761325/controlled-release-of-bacillus-thurigiensis-formulations-encapsulated-in-light-resistant-colloidosomal-microcapsules-for-the-management-of-lepidopteran-pests-of-brassica-crops
#20
Oumar Bashir, Jerome P Claverie, Pierre Lemoyne, Charles Vincent
Bacillus thuringiensis (B. t.) based formulations have been widely used to control lepidopteran pests in agriculture and forestry. One of their weaknesses is their short residual activity when sprayed in the field. Using Pickering emulsions, mixtures of spores and crystals from three B. t. serovars were successfully encapsulated in colloïdosomal microparticles (50 μm) using innocuous chemicals (acrylic particles, sunflower oil, iron oxide nanoparticles, ethanol and water). A pH trigger mechanism was incorporated within the particles so that B...
2016: PeerJ
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