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https://www.readbyqxmd.com/read/28532010/design-of-experiments-for-microencapsulation-applications-a-review
#1
REVIEW
Filipa Paulo, Lúcia Santos
Microencapsulation techniques have been intensively explored by many research sectors such as pharmaceutical and food industries. Microencapsulation allows to protect the active ingredient from the external environment, mask undesired flavours, a possible controlled release of compounds among others. The purpose of this review is to provide a background of design of experiments in microencapsulation research context. Optimization processes are required for an accurate research in these fields and therefore, the right implementation of micro-sized techniques at industrial scale...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531662/microencapsulation-of-gulosibacter-molinativorax-on4-t-cells-by-a-spray-drying-process-using-different-biopolymers
#2
Berta N Estevinho, A Rita Lopes, Vera Sousa, Fernando Rocha, Olga C Nunes
Molinate is a thiocarbamate herbicide used in rice crop protection. As other pesticides, molinate is a recognized environmental pollutant and bio-accumulated by some wildlife forms. Gulosibacter molinativorax ON4(T) is able to hydrolyse molinate into metabolites which are further degraded by other un-related bacteria. Hence, it can be used in molinate bioremediation processes. The aim of this work was to investigate the possibility of producing G. molinativorax ON4(T) microparticles, using different non-toxic biopolymers (arabic gum, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process...
May 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28530583/microencapsulation-structures-based-on-protein-coated-liposomes-obtained-through-electrospraying-for-the-stabilization-and-improved-bioaccessibility-of-curcumin
#3
Laura G Gómez-Mascaraque, Caroline Casagrande Sipoli, Lucimara Gaziola de La Torre, Amparo López-Rubio
Novel food-grade hybrid encapsulation structures based on the entrapment of phosphatidylcholine liposomes, within a WPC matrix through electrospraying, were developed and used as delivery vehicles for curcumin. The loading capacity and encapsulation efficiency of the proposed system was studied, and the suitability of the approach to stabilize curcumin and increase its bioaccessibility was assessed. Results showed that the maximum loading capacity of the liposomes was around 1.5% of curcumin, although the loading capacity of the hybrid microencapsulation structures increased with the curcumin content by incorporation of curcumin microcrystals upon electrospraying...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28530150/the-roles-of-bile-acids-and-applications-of-microencapsulation-technology-in-treating-type-1-diabetes-mellitus
#4
Louise Woodhams, Hani Al-Salami
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the liver and solely metabolized by gut microflora. This review investigates their potential oral delivery in T1DM using targeted delivery and encapsulation technologies. A sensitive and selective search was carried out using different search engines and databases...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28529037/diabetes-development-increased-concentrations-of-the-conjugated-bile-acid-taurocholic-acid-in-serum-while-treatment-with-microencapsulated-taurocholic-acid-exerted-no-hypoglycaemic-effects
#5
Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon, Hani Al-Salami
CONTEXT: The bile acid taurocholic acid (TCA) is endogenously produced, and has shown formulation-stabilising effects when incorporated into microcapsules containing potential antidiabetic drugs. This study aimed to develop and characterise TCA-microcapsules, and test their antidiabetic effects, in an animal model of Type 1 diabetes (T1D). METHODS: Using the polymer sodium alginate (SA), SA-microcapsules (control) and TCA-microcapsules (test) were prepared, and assessed for morphology, surface composition, chemical and thermal stability, swelling, buoyancy, mechanical, release and rheological properties...
May 18, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28528112/microencapsulation-and-characterization-of-liposomal-vesicles-using-a-supercritical-fluid-process-coupled-with-vacuum-driven-cargo-loading
#6
Wen-Chyan Tsai, Syed S H Rizvi
A new technique of liposomal microencapsulation, consisting of supercritical fluid extraction followed by rapid expansion of the supercritical solution and vacuum-driven cargo loading, was successfully developed. It is a continuous flow-through process without usage of any toxic organic solvent. For use as a coating material, the solubility of soy phospholipids in supercritical carbon dioxide was first determined using a dynamic equilibrium system and the data was correlated with the Chrastil model with good agreement...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28528002/iron-microencapsulation-in-gum-tragacanth-using-solvent-evaporation-method
#7
Elham Asghari-Varzaneh, Mohammad Shahedi, Hajar Shekarchizadeh
In this study iron salt (FeSO4·7H2O) was microencapsulated in gum tragacanth hydrogel using solvent evaporation method. Three significant parameters (ferrous sulfate content, content of gum tragacanth, and alcohol to mixture ratio) were optimized by response surface methodology to obtain maximum encapsulation efficiency. Ferrous sulfate content, 5%, content of gum tragacanth, 22%, and alcohol to mixture ratio, 11:1 was determined to be the optimum condition to reach maximum encapsulation efficiency. Microstructure of iron microcapsules was thoroughly monitored using scanning electron microscopy (SEM)...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28523592/islet-microencapsulation-strategies-and-clinical-status-in-diabetes
#8
REVIEW
Mustafa Omami, James J McGarrigle, Mick Reedy, Douglas Isa, Sofia Ghani, Enza Marchese, Matthew A Bochenek, Maha Longi, Yuan Xing, Ira Joshi, Yong Wang, José Oberholzer
PURPOSE OF REVIEW: Type 1 diabetes mellitus (T1DM) is an autoimmune disease that results from the destruction of insulin-producing pancreatic β cells in the islets of Langerhans. Islet cell transplantation has become a successful therapy for specific patients with T1DM with hypoglycemic unawareness. The reversal of T1DM by islet transplantation is now performed at many major medical facilities throughout the world. However, many challenges must still be overcome in order to achieve continuous, long-term successful transplant outcomes...
July 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28516893/design-of-electrohydrodynamic-sprayed-polyethylene-glycol-hydrogel-microspheres-for-cell-encapsulation
#9
Anisa S Qayyum, Era Jain, Grant Kolar, Yonghyun Kim, Scott A Sell, Silviya P Zustiak
Electrohydrodynamic spraying (EHS) has recently gained popularity for microencapsulation of cells for applications in cell delivery and tissue engineering. Some of the polymers compatible with EHS are alginate, chitosan, and other similar natural polymers, which are subject to ionotropic or physical gelation. It is desirable to further extend the use of the EHS technique beyond such polymers for wider biofabrication applications. Here, building upon our previous work of making PEG microspheres via EHS, we utilized the principles of EHS to fabricate cell-laden polyethylene glycol (PEG) hydrogel microspheres...
May 18, 2017: Biofabrication
https://www.readbyqxmd.com/read/28509918/generation-and-manipulation-of-hydrogel-microcapsules-by-droplet-based-microfluidics-for-mammalian-cell-culture
#10
REVIEW
Haishui Huang, Yin Yu, Yong Hu, Xiaoming He, O Berk Usta, Martin L Yarmush
Hydrogel microcapsules provide miniaturized and biocompatible niches for three-dimensional (3D) in vitro cell culture. They can be easily generated by droplet-based microfluidics with tunable size, morphology, and biochemical properties. Therefore, microfluidic generation and manipulation of cell-laden microcapsules can be used for 3D cell culture to mimic the in vivo environment towards applications in tissue engineering and high throughput drug screening. In this review of recent advances mainly since 2010, we will first introduce general characteristics of droplet-based microfluidic devices for cell encapsulation with an emphasis on the fluid dynamics of droplet breakup and internal mixing as they directly influence microcapsule's size and structure...
May 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28507056/parallel-in-vivo-monitoring-of-ph-in-gill-capillaries-and-muscles-of-fishes-using-microencapsulated-biomarkers
#11
Ekaterina Borvinskaya, Anton Gurkov, Ekaterina Shchapova, Boris Baduev, Zhanna Shatilina, Anton Sadovoy, Igor Meglinski, Maxim Timofeyev
Tracking physiological parameters in different organs within the same organism simultaneously and in real time can provide an outstanding representation of the organism's physiological status. The state-of-the-art technique of using encapsulated fluorescent molecular probes (microencapsulated biomarkers) is a unique tool that can serve as a platform for the development of new methods to obtain in vivo physiological measurements and is applicable to a broad range of organisms. Here, we describe a novel technique to monitor the pH of blood inside the gill capillaries and interstitial fluid of muscles by using microencapsulated biomarkers in a zebrafish model...
May 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28494101/stability-enhancement-of-ocimum-sanctum-linn-essential-oils-using-stearic-acid-in-aluminum-carboxymethyl-cellulose-film-coated-gelatin-microcapsules
#12
Pakamon Chitprasert, Narisara Ngamekaue
Holy basil essential oils (HBEO) can be used in many food applications due to antioxidant and antimicrobial attributes, but they are susceptible to degradation upon storage. Therefore, a protective system is required to extend their shelf life. HBEO was microencapsulated by coacervation using gelatin and the microcapsules were subsequently coated with stearic acid (1%, 2%, and 3%) in carboxymethyl cellulose emulsions. The results showed that HBEO contents decreased with increasing stearic acid concentrations from 76% to 59%...
May 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28493309/effect-of-nanoemulsified-and-microencapsulated-mexican-oregano-lippia-graveolens-kunth-essential-oil-coatings-on-quality-of-fresh-pork-meat
#13
Elvia Hernández-Hernández, César Y Lira-Moreno, Isabel Guerrero-Legarreta, Graciela Wild-Padua, Prospero Di Pierro, Blanca E García-Almendárez, Carlos Regalado-González
Fresh meat is a highly perishable food. This work aimed to evaluate the influence of Mexican oregano (Lippia graveolens Kunth) incorporated into active coatings (ACs) spread on fresh pork meat as free (FEO), nanoemulsified (NEO), and microencapsulated (MEO) essential oil (EO), on its microbiological, physicochemical and sensory properties during 15 d at 4 ± 1 °C. Thymol and γ-terpinene were identified in the EO. In vitro effect of 2.85 mg EO/cm(2) was tested against Brochothrix thermosphacta, Micrococcus luteus, Lactobacillus plantarum, Pseudomonas fragi, and Salmonella Infantis...
May 10, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28493103/cellulose-derivatives-enhanced-stability-of-alginate-based-beads-loaded-with-lactobacillus-plantarum-lab12-against-low-ph-high-temperature-and-prolonged-storage
#14
Ismail M Fareez, Siong Meng Lim, Nurul Aida Ashyqin Zulkefli, Rakesh K Mishra, Kalavathy Ramasamy
The susceptibility of probiotics to low pH and high temperature has limited their use as nutraceuticals. In this study, enhanced protection of probiotics via microencapsulation was achieved. Lactobacillus plantarum LAB12 were immobilised within polymeric matrix comprised of alginate (Alg) with supplementation of cellulose derivatives (methylcellulose (MC), sodium carboxymethyl cellulose (NaCMC) or hydroxypropyl methylcellulose (HPMC)). L. plantarum LAB12 encapsulated in Alg-HPMC(1.0) and Alg-MC(1.0) elicited improved survivability (91%) in simulated gastric conditions and facilitated maximal release (∼100%) in simulated intestinal condition...
May 10, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28492663/a-versatile-microfluidic-device-for-high-throughput-production-of-microparticles-and-cell-microencapsulation
#15
Samin Akbari, Tohid Pirbodaghi, Roger D Kamm, Paula T Hammond
Biocompatible microparticles are valuable tools in biomedical research for applications such as drug delivery, cell transplantation therapy, and analytical assays. However, their translation into clinical research and the pharmaceutical industry has been slow due to the lack of techniques that can produce microparticles with controlled physicochemical properties at high throughput. We introduce a robust microfluidic platform for the production of relatively homogeneous microdroplets at a generation frequency of up to 3...
May 11, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28485486/in-vitro-digestion-and-fermentation-of-microencapsulated-tributyrin-for-the-delivery-of-butyrate
#16
Joseph D Donovan, Laura Bauer, George C Fahey, Youngsoo Lee
Butyrate possesses negative sensory qualities and is most effectively utilized in the intestine to provide energy to the colonocyte for the maintenance of intestinal health. Butyrate has also shown promise in the treatment of intestinal disorders and diseases such as short bowel syndrome, inflammatory bowel disease, and colon cancer. To modify sensory properties, intestinal release, and butyrate production capabilities, tributyrin (TB) was microencapsulated in whey protein isolate (WPI)-based and gamma-cyclodextrin (GC)-based materials...
May 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28460917/healthy-spanish-salchich%C3%A3-n-enriched-with-encapsulated-n-3-long-chain-fatty-acids-in-konjac-glucomannan-matrix
#17
Jose M Lorenzo, Paulo Eduardo Sichetti Munekata, Mirian Pateiro, Paulo Cezar Bastianello Campagnol, Ruben Domínguez
Reduction of fat content and improving fatty acid composition were the strategies used to reformulate Spanish salchichón with better lipid content by partial substitution of pork backfat by microencapsulated fish oil in konjac glucomannan matrix. For the present study, four different batches were manufactured: control (CO) with 100% of pork backfat and ME25, ME50 and ME75 where the pork backfat was replaced with 25, 50 and 75% by microencapsulated fish oil, respectively. The fat replacement by microencapsulated fish oil was accompanied by a decrease (P<0...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28457464/alginate-based-nanocomposite-for-microencapsulation-of-probiotic-effect-of-cellulose-nanocrystal-cnc-and-lecithin
#18
Tanzina Huq, Carole Fraschini, Avik Khan, Bernard Riedl, Jean Bouchard, Monique Lacroix
Probiotic (Lactobacillus rhamnosus ATCC 9595) was encapsulated in alginate-CNC-lecithin microbeads to produce nutraceutical microcapsules. Addition of CNC and lecithin in alginate microbeads (ACL-1) improved the viability of L. rhamnosus during gastric passage and storage. The compression strength of the freeze-dried ACL-1 microbeads improved 40% compared to alginate microbeads alone. Swelling studies revealed that addition of CNC and lecithin in alginate microbeads decreased (around 47%) the gastric fluid absorption but increased the dissolution time by 20min compared to alginate microbeads (A-0)...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28457455/alginate-microparticles-as-oral-colon-drug-delivery-device-a-review
#19
REVIEW
Lissette Agüero, Dionisio Zaldivar-Silva, Luis Peña, Marcos L Dias
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery. Among the well known alginate properties, pH sensitivity remains as an attractive option for targeting of drug in the colon region. This essential aspect is advantageous to enhance therapeutic efficacy of treatment of inflammatory bowel diseases, which require multi-drug administration frequently in a long period. As consequence, severe side effect appears leading to discontinuation of therapy and affecting quality of patient life...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28455535/one-step-fabrication-of-ph-responsive-membranes-and-microcapsules-through-interfacial-h-bond-polymer-complexation
#20
Julien Dupré de Baubigny, Corentin Trégouët, Thomas Salez, Nadège Pantoustier, Patrick Perrin, Mathilde Reyssat, Cécile Monteux
Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively...
April 28, 2017: Scientific Reports
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