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Microencapsulation

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https://www.readbyqxmd.com/read/28213468/microencapsulation-of-lefty-secreting-engineered-cells-for-pulmonary-fibrosis-therapy-in-mice
#1
Hongge Ma, Shupei Qiao, Zeli Wang, Shuai Geng, Yufang Zhao, Xiaolu Hou, Weiming Tian, Xiongbiao Chen, Lifen Yao
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that causes unremitting deposition of extracellular matrix proteins, thus resulting in distortion of the pulmonary architecture and impaired gas exchange. Associated with high morbidity and mortality, IPF is generally refractory to current pharmacological therapies. Lefty A, a potent inhibitor of transforming growth factor (TGF)-β signaling, has been shown to have promising antifibrotic ability in vitro for the treatment of renal fibrosis and other potential organ fibroses...
February 17, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28208818/hydroxycinnamic-acids-and-their-derivatives-cosmeceutical-significance-challenges-and-future-perspectives-a-review
#2
Oludemi Taofiq, Ana M González-Paramás, Maria Filomena Barreiro, Isabel C F R Ferreira
Bioactive compounds from natural sources, due to their widely-recognized benefits, have been exploited as cosmeceutical ingredients. Among them, phenolic acids emerge with a very interesting potential. In this context, this review analyzes hydroxycinnamic acids and their derivatives as multifunctional ingredients for topical application, as well as the limitations associated with their use in cosmetic formulations. Hydroxycinnamic acids and their derivatives display antioxidant, anti-collagenase, anti-inflammatory, antimicrobial and anti-tyrosinase activities, as well as ultraviolet (UV) protective effects, suggesting that they can be exploited as anti-aging and anti-inflammatory agents, preservatives and hyperpigmentation-correcting ingredients...
February 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28206859/evaluation-and-adaptation-of-attractive-toxic-sugar-baits-for-culex-tarsalis-and-culex-quinquefasciatus-control-in-the-coachella-valley-southern-california
#3
Whitney A Qualls, Jodi Scott-Fiorenzano, Gunter C Müller, Kristopher L Arheart, John C Beier, Rui-De Xue
The project goal was to determine how a new vector control strategy that targets the sugar-feeding behavior of mosquitoes, attractive toxic sugar baits (ATSBs), can be used to more effectively control West Nile virus (WNV) vectors in the Coachella Valley, California. Three laboratory studies were conducted to determine the utility of this method for control against Culex quinquefasciatus and Culex tarsalis : 1) efficacy evaluations of 2 formulations of ATSB, microencapsulated garlic oil, and a combination of microencapsulated garlic oil and 1% boric acid; 2) choice assays to determine the attractiveness of ATSB with the microencapsulated garlic oil against attractive sugar baits (ASB; the attractant alone; without toxin) and a 10% sucrose solution; and 3) vegetation efficacy tests on 3 common plant species in the Coachella Valley, Atriplex lentiformis, Tamarix ramosissima , and Pluchea sericea...
December 2016: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28193419/chemical-stability-of-astaxanthin-integrated-into-a-food-matrix-effects-of-food-processing-and-methods-for-preservation
#4
REVIEW
Alejandra Anahí Martínez-Delgado, Sanghamitra Khandual, Socorro Josefina Villanueva-Rodríguez
Astaxanthin is a carotenoid pigment found in numerous organisms ranging from bacteria to algae, yeasts, plants, crustaceans and fish such as salmon. Technological importance of this pigment emerged from various studies demonstrating that it is a powerful antioxidant, even with higher activity than alpha-tocopherol and other carotenoids. It has been included in various pharmaceutical products because of several beneficial properties. By its nature, astaxanthin is susceptible to degradation and can undergo chemical changes during food processing...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28165891/dispersion-and-oxidative-stability-of-o-w-emulsions-and-oxidation-of-microencapsulated-oil
#5
Yayoi Miyagawa, Shuji Adachi
Oil-in-water (O/W) emulsions are among the dispersion systems commonly used in food, and these emulsions are in thermodynamically unstable or metastable states. In this paper, various methods for preparing O/W emulsions are outlined. Since the commodity value of food is impaired by the destabilization of O/W emulsions, experimental and theoretical approaches to assess the stability of O/W emulsions are overviewed, and factors affecting the dispersion stability of emulsions are discussed based on the DLVO theory and the concept of the stability factor...
February 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28150116/subcutaneous-implantation-of%C3%A2-microencapsulated-cells-overexpressing-%C3%AE-l-iduronidase-for-mucopolysaccharidosis-type-i-treatment
#6
Valeska Lizzi Lagranha, Barbara Zambiasi Martinelli, Guilherme Baldo, Giuseppe Ávila Testa, Talita Giacomet de Carvalho, Roberto Giugliani, Ursula Matte
Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of α-L-iduronidase (IDUA), resulting in accumulation of glycosaminoglycans (GAG) in lysosomes. Microencapsulation of recombinant cells is a promising gene/cell therapy approach that could overcome the limitations of the current available treatments. In the present study we produced alginate-poly-L-lysine-alginate (APA) microcapsules containing recombinant cells overexpressing IDUA, which were implanted in the subcutaneous space of MPS I mice in order to evaluate their potential effect as a treatment for this disease...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28132503/effect-of-drying-methods-on-protein-and-dna-conformation-changes-in-lactobacillus-rhamnosus-gg-cells-by-fourier-transform-infrared-spectroscopy
#7
Mya M Hlaing, Bayden R Wood, Don McNaughton, DanYang Ying, Geoff Dumsday, Mary Ann Augustin
Microencapsulation protects cells against environmental stress encountered during the production of probiotics, which are used as live microbial food ingredients. Freeze-drying and spray-drying are used in the preparation of powdered microencapsulated probiotics. This study examines the ability of Fourier transform infrared (FTIR) spectroscopy to detect differences in cells exposed to freeze-drying and spray-drying of encapsulated Lactobacillus rhamnosus GG cells. The FTIR analysis clearly demonstrated there were more significant molecular changes in lipid, fatty acid content, protein, and DNA conformation of nonencapsulated compared to encapsulated bacterial cells...
February 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28129937/determination-of-cinnamaldehyde-carvacrol-and-thymol-in-feedstuff-additives-by-pressurized-liquid-extraction-followed-by-gas-chromatography-mass-spectrometry
#8
Marta Jiménez-Salcedo, María Teresa Tena
Specific blends of essential oils (BEOs) are promising substitutes for antibiotics to promote livestock performance and to reduce the incidence of intestinal disorders. Microencapsulation of BEOs has shown to improve their stability, bioavailability and to control their release rate once they are added to the feedstuff. The development and validation of a method for determining essential oil components such as carvacrol, thymol and cinnamaldehyde in a microencapsulated material used as feed additive is presented...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28129106/a-synthetic-mammalian-therapeutic-gene-circuit-for-sensing-and-suppressing-inflammation
#9
Anže Smole, Duško Lainšček, Urban Bezeljak, Simon Horvat, Roman Jerala
Inflammation, which is a highly regulated host response against danger signals, may be harmful if it is excessive and deregulated. Ideally, anti-inflammatory therapy should autonomously commence as soon as possible after the onset of inflammation, should be controllable by a physician, and should not systemically block beneficial immune response in the long term. We describe a genetically encoded anti-inflammatory mammalian cell device based on a modular engineered genetic circuit comprising a sensor, an amplifier, a "thresholder" to restrict activation of a positive-feedback loop, a combination of advanced clinically used biopharmaceutical proteins, and orthogonal regulatory elements that linked modules into the functional device...
January 4, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28125351/in-vitro-release-kinetics-of-microencapsulated-materials-and-the-effect-of-the-food-matrix
#10
Floirendo P Flores, Fanbin Kong
Many biomaterials are encapsulated to preserve their health-promoting properties and promote targeted delivery. Numerous papers have been published about extraction and purification methods, encapsulation techniques, and release properties of encapsulated biomaterials. Despite the abundant information, the food applications of encapsulated materials are currently limited. One approach to increase the food applications is to investigate the mathematical aspects of release behavior and the effect of the food matrix...
January 18, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28121472/plasma-creatine-kinetics-after-ingestion-of-microencapsulated-creatine-monohydrate-with-enhanced-stability-in-aqueous-solutions
#11
Michelle Hone, Robert M Kent, Alessandro Scotto di Palumbo, Sinead B Bleiel, Giuseppe De Vito, Brendan Egan
Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencapsulated CRE (3-g creatine monohydrate; n = 5) conditions. Experimental conditions involved ingestion of the samples in a 70-mL ready-to-drink format. CRE was delivered in a novel microencapsulation matrix material consisting entirely of hydrolyzed milk protein...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28120922/microencapsulation-with-alginate-caco3-a-strategy-for-improved-phage-therapy
#12
Joan Colom, Mary Cano-Sarabia, Jennifer Otero, Javier Aríñez-Soriano, Pilar Cortés, Daniel Maspoch, Montserrat Llagostera
Bacteriophages are promising therapeutic agents that can be applied to different stages of the commercial food chain. In this sense, bacteriophages can be orally administered to farm animals to protect them against intestinal pathogens. However, the low pH of the stomach, the activities of bile and intestinal tract enzymes limit the efficacy of the phages. This study demonstrates the utility of an alginate/CaCO3 encapsulation method suitable for bacteriophages with different morphologies and to yield encapsulation efficacies of ~100%...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28118715/hybrid-alginate-protein-coated-graphene-oxide-microcapsules-enhance-the-functionality-of-erythropoietin-secreting-c2c12-myoblasts
#13
Laura Saenz Del Burgo, Jesús Ciriza, Argia Acarregui, Haritz Gurruchaga, Francisco Javier Blanco, Gorka Orive, Rosa María Hernández, Jose Luis Pedraz
The beneficial effect of combining alginate hydrogel with graphene oxide (GO) on microencapsulated C2C12-myoblast viability has recently been described. However, the commercially available GO lacks homogeneity in size, this parameter being of high relevance for the cell fate in two-dimensional studies. In three-dimensional applications the capacity of this material for binding different kinds of proteins can result in the reduction of de novo released protein that can effectively reach the vicinity of the microcapsules...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28109101/-fgf-2-pela-bmp-2-microcapsule-scaffold-promotes-osteogenic-differentiation-of-rat-periosteum-derived-stem-cells-in-vitro
#14
Jie Yin, Su-Jun Qiu, Jun-Huai Gao, Sheng-Li Zhao, Shao-Xiong Min
OBJECTIVE: To observe the effect of a microencapsule scaffold capable of sustained release of fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 (BMP-2) in promoting the osteogenic differentiation of rat periosteum-derived stem cells (PDSCs) in vitro. METHODS: PDSCs from 4-week-old SD rats, after identification of the surface markers using flow cytometry, were induced to differentiate into osteoblast, chondroblast, and adipocyte lineages. The differentiated cells were verified by staining with Alizarin red, toluidine blue, alcian blue, oil red O and by immunofluorescence assay...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28106710/banana-passion-fruit-passiflora-mollissima-kunth-l-h-bailey-microencapsulation-phytochemical-composition-and-antioxidant-capacity
#15
Almudena García-Ruiz, Amadeo Girones-Vilaplana, Paola León, Diego A Moreno, Carla M Stinco, Antonio J Meléndez-Martínez, Jenny Ruales
Passiflora mollissima (Kunth) L.H. Bailey is an exotic fruit native to South America, known as taxo in Ecuador. This paper characterizes its flavonoid and carotenoid composition and antioxidant capacity and evaluates the effect of the spray-drying process on its phytochemical composition and antioxidant capacity. A total of 18 flavonoid compounds, nine proanthocyanidins and nine flavan-3-ol monomers, were identified and quantified. Glycosides of (epi)-afzelechin stood out as the most abundant flavonoid. Three carotenoids were identified, with β-carotene having the highest concentration...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28094929/effect-of-in-vitro-gastrointestinal-digestion-on-encapsulated-and-nonencapsulated-phenolic-compounds-of-carob-ceratonia-siliqua-l-pulp-extracts-and-their-antioxidant-capacity
#16
Siham Ydjedd, Sihem Bouriche, Rubén López-Nicolás, Teresa Sánchez-Moya, Carmen Frontela-Saseta, Gaspar Ros-Berruezo, Farouk Rezgui, Hayette Louaileche, Djamel-Edine Kati
To determine the effect of in vitro gastrointestinal digestion on the release and antioxidant capacity of encapsulated and nonencapsulated phenolics carob pulp extracts, unripe and ripe carob pulp extracts were microencapsulated with polycaprolactone via double emulsion/solvent evaporation technique. Microcapsules' characterization was performed using scanning electron microscopy and Fourier transform infrared spectrometry analysis. Total phenolics and flavonoids content and antioxidant activities (ORAC, DPPH, and FRAP) were evaluated after each digestion step...
February 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28093323/in-vitro-gastric-survival-of-commercially-available-probiotic-strains-and-oral-dosage-forms
#17
Romain Caillard, Nicolas Lapointe
Although the intestinal microbial community is still incompletely understood, there is strong evidence of the benefits of using probiotics to address some medical states or conditions. As a result, the probiotics oral supplements market has exploded during the last few years. However, while their sensitivity to gastric juices, acidic pH and bile is well known, most of these oral forms would not guarantee any survival of the strains in such conditions. In this work, we have studied the resistance to simulated gastric juices of several commercially available probiotics products...
January 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28079006/a-new-vaccine-delivery-vehicle-and-adjuvant-candidate-bordetella-pertussis-inactivated-whole-cells-entrapped-in-alginate-microspheres
#18
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
There is no doubt about whole cell pertussis vaccine efficacy, but it is necessary to improve the vaccine quality specially to decreasing its toxicity by obtaining good immunogenicity with low bacteria number content. In this work, under optimum condition inactivated B. pertussis bacteria cells entrapped alginate microparticles were fabricated and in vivo immunogenicity and potency of new microparticle based vaccine evaluated in mice. Microspheres loaded inactive B. pertussis bacterium cells were prepared via an emulsification method and analyzed for morphology, size, polydispersity index, loading efficiency, loading capacity, release profile and in vivo potency...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28075551/cucurbit-n-uril-based-microcapsules-self-assembled-within-microfluidic-droplets-a-versatile-approach-for-supramolecular-architectures-and-materials
#19
Ji Liu, Yang Lan, Ziyi Yu, Cindy S Y Tan, Richard M Parker, Chris Abell, Oren A Scherman
Microencapsulation is a fundamental concept behind a wide range of daily applications ranging from paints, adhesives, and pesticides to targeted drug delivery, transport of vaccines, and self-healing concretes. The beauty of microfluidics to generate microcapsules arises from the capability of fabricating monodisperse and micrometer-scale droplets, which can lead to microcapsules/particles with fine-tuned control over size, shape, and hierarchical structure, as well as high reproducibility, efficient material usage, and high-throughput manipulation...
January 11, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28070061/injectable-alginate-microencapsulated-canine-adipose-tissue-derived-mesenchymal-stem-cells-for-enhanced-viable-cell-retention
#20
Eunji Koh, Yun Chan Jung, Heung-Myong Woo, Byung-Jae Kang
The purpose of this study was to establish an optimized protocol for the production of alginate-encapsulated canine adipose-derived mesenchymal stem cells (cASCs) and evaluate their suitability for clinical use, including viability, proliferation and in vivo cell retention. Alginate microbeads were formed by vibrational technology and the production of injectable microbeads was performed using various parameters with standard methodology. Microbead toxicity was tested in an animal model. Encapsulated cASCs were evaluated for viability and proliferation in vitro...
January 6, 2017: Journal of Veterinary Medical Science
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