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R I Ortiz-Basurto, M E Rubio-Ibarra, J A Ragazzo-Sanchez, C I Beristain, M Jiménez-Fernández
The objective of this work was to microencapsulate pitanga (Eugenia uniflora L.) juice by spray drying, using High Performance Agave Fructans (HPAF) and High Degree of Polymerisation Agave Fructans (HDPAF) and maltodextrin (MD), respectively, as the wall materials. The physicochemical and antioxidant properties of the capsules during storage at various temperatures were evaluated. The microparticles developed using fructans HPAF and HDPAF, exhibited similar physicochemical and flow properties to those presented by the microparticles prepared with MD...
November 1, 2017: Carbohydrate Polymers
Fahim Tamzeedul Karim, Kashif Ghafoor, Sahena Ferdosh, Fahad Al-Juhaimi, Eaqub Ali, Kamaruzzaman Bin Yunus, Mir Hoseini Hamed, Ashraful Islam, Mohammad Asif, Mohammed Zaidul Islam Sarker
In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using hydroxypropyl methyl cellulose as a polymer. Three factors, namely, temperature, pressure, and feed emulsion rate were optimized using response surface methodology. The suitability of the model for predicting the optimum response value was evaluated at the conditions of temperature at 60°C, pressure at 150 bar, and feed rate at 1.36 mL/min. At the optimum conditions, particle size of 58...
July 2017: Journal of Food and Drug Analysis
Vittoria Pandolfi, Ulysse Pereira, Murielle Dufresne, Cécile Legallais
Increasing numbers of requests for transplantable organs and their scarcity has led to a pressing need to find alternative solutions to standard transplantation. An appealing but challenging proposal came from the fields of tissue engineering and regenerative medicine, the purpose of which is to build tissues/organs from scratch in the laboratory and use them as either permanent substitutes for direct implantation into the patient's body, or as temporary substitutes to bridge patients until organ regeneration or transplantation...
June 8, 2017: Current Pharmaceutical Design
Dong-Min Kim, Yu-Jin Cho, Ju-Young Choi, Beom-Jun Kim, Seung-Won Jin, Chan-Moon Chung
Low-temperature self-healing capabilities are essential for self-healing materials exposed to cold environments. Although low-temperature self-healing concepts have been proposed, there has been no report of a microcapsule-type low-temperature self-healing system wherein the healing ability was demonstrated at low temperature. In this work, low-temperature self-healing of a microcapsule-type protective coating was demonstrated. This system employed silanol-terminated polydimethylsiloxane (STP) as a healing agent and dibutyltin dilaurate (DD) as a catalyst...
September 14, 2017: Materials
Tania Belen Lopez-Mendez, Edorta Santos-Vizcaino, Francisco Javier Blanco, Jose Luis Pedraz, Rosa Maria Hernandez, Gorka Orive
The combination of multipotent mesenchymal stromal cells (MSCs) and different biomaterials has led to enormous advances in cell-based therapies, among which cell microencapsulation technologies are included. In the present work, we have studied the influence of different cell densities on the behavior of erythropoietin (EPO)-secreting MSCs immobilized in alginate microcapsules for their use as drug delivery systems. In vitro studies showed a more sustained and controlled EPO-secretion in groups with higher cell densities, which may be related to a more balanced renewal of the encapsulated cells, while low and intermediate densities gave rise to a continuous increase of both the number of cells and the EPO secretion levels...
September 7, 2017: International Journal of Pharmaceutics
Wen Zeng, Zhongyang Liu, Yuqian Li, Shu Zhu, Jie Ma, Weixin Li, Guodong Gao
The microencapsulation of bioactive neurotrophic factors in biodegradable poly(lactide-co-glycolide) (PLGA) microspheres has been a promising tool in the treatment of various nervous system disorders. However, challenges still exist; the PLGA burst drug release and acidic degradation products often limit clinical application. In this study, cores-shell PLGA-chitosan microparticles (MPs) were fabricated with a single shell of chitosan and multi-cores of PLGA using a re-emulsification method. The glial cell line-derived neurotrophic factor (GDNF) was encapsulated at the PLGA cores of the cores-shell MPs...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
Anna Blocki, Farina Löper, Nino Chirico, Axel T Neffe, Friedrich Jung, Christof Stamm, Andreas Lendlein
Cell-based therapies often face the challenge of low cell retention and viability upon transplantation. Hence, biomaterials, which can immobilize transplanted cells, while at the same time support cell viability, are essential for successful clinical application. Noteworthy, biomaterials in the micrometer range such as microcapsules have the advantage of a minimally invasive introduction into tissue.Hence, we established an approach to generate gelatin-based cell carriers in the form of microspherical hydrogels...
September 4, 2017: Clinical Hemorheology and Microcirculation
Bin Bin Huang, Shao Fei Zhang, Peng Hao Chen, Gang Wu
The dynamics of release and degradation of the microencapsulation formulation containing spinosad (SP) and emamectin benzoate (EM) were evaluated in the present study. SP and EM were microencapsulated using biodegradable poly-lactic acid (PLA) as the wall material. Their release from and degradation within the prepared SP and EM microspheres (SP-EM-microspheres) were studied. It was found that the encapsulation significantly prolonged the insecticide release. The release could be further extended if the external aqueous phase was pre-saturated with the insecticides and the microspheres were additionally coated with gelatin...
September 7, 2017: Scientific Reports
Dirnete Diel, Valeska Lizzi Lagranha, Roselena Silvestri Schuh, Fernanda Bruxel, Ursula Matte, Helder Ferreira Teixeira
Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disease caused by deficiency of α-l-iduronidase (IDUA), which results in the lysosomal accumulation of glycosaminoglycans (GAG) leading to widespread clinical manifestations. The microencapsulation of IDUA overexpressing recombinant cells has been considered as a promising strategy for the treatment of MPS I. This study aimed at the optimization of alginate microcapsules containing recombinant BHK (Baby Hamster Kidney) cells (rBHK) overexpressing IDUA produced by electrostatic extrusion technique...
September 4, 2017: European Journal of Pharmaceutical Sciences
Chen Chen, Junling Wu, Michael D Weir, Lin Wang, Xuedong Zhou, Hockin H K Xu, Mary Anne S Melo
Fracture and secondary caries are the primary reasons for the failure of dental restorations. To face this omnipresent problem, we report the formulation design and synthesis of a protein-resistant dental composite composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) that also can self-repair damage and recover the load-bearing capability via microencapsulated triethylene glycol dimethacrylate (TEGDMA) and N,N-dihydroxy ethyl-p-toluidine (DHEPT). The bioactivity of the resulting MPC-microencapsulated TEGDMA-DHEPT was evaluated on protein adsorption through early bacterial attachment...
September 7, 2017: Journal of Functional Biomaterials
Akkaratch Rodklongtan, Pakamon Chitprasert
Lipid peroxidation induced by oxidative stress plays an important role in reducing probiotic survival during spray drying. In this study, the probiotic Lactobacillus reuteri KUB-AC5 was co-encapsulated with holy basil essential oil, HBEO (0, 6, and 12mg/ml), by spray drying using skim milk at inlet air temperatures of 130, 140, and 150°C. The microcapsule properties in terms of morphology, size, moisture content, water activity, surface oil, microencapsulation efficiency, antioxidant activity, lipid peroxidation, and cell survival were determined...
October 2017: Food Research International
Bilal Ahmad Ashwar, Asir Gani, Adil Gani, Asima Shah, Farooq Ahmad Masoodi
The research reported in this article is based on the hypothesis that crosslinking of starch can make it a potential wall material for targeted delivery of probiotics by altering its digestion. Three probiotic strains namely Lactobacillus casei, Lactobacillus brevis and Lactobacillus plantarum were microencapsulated with resistant starch. Encapsulation yield (%) of resistant starch microspheres was in the range of 43.01-48.46. The average diameter of resistant starch microparticles was in the range of 45.53-49...
January 15, 2018: Food Chemistry
Jasmina Hadzieva, Kristina Mladenovska, Maja Simonoska Crcarevska, Marija Glavaš Dodov, Simona Dimchevska, Nikola Geškovski, Anita Grozdanov, Emil Popovski, Gjorgji Petruševski, Marina Chachorovska, Tanja Petreska Ivanovska, Lidija Petruševska-Tozi, Sonja Ugarkovic, Katerina Goracinova
This article presents a novel formulation for preparation of Lactobacillus casei 01 encapsulated in soy protein isolate and alginate microparticles using spray drying method. A response surface methodology was used to optimise the formulation and the central composite face-centered design was applied to study the effects of critical material attributes and process parameters on viability of the probiotic after microencapsulation and in simulated gastrointestinal conditions. Spherical microparticles were produced in high yield (64%), narrow size distribution (d50=9...
June 2017: Food Technology and Biotechnology
O Tomazelli, F Kuhn, P J M Padilha, L R M Vicente, S W Costa, A A Boligon, J Scapinello, C N Nesi, J Dal Magro, S Lamo Castellví
The aims of this research were first, to evaluate the antibacterial potential of commercial thyme essential oil against V. alginolyticus and V. parahaemolyticys and second, using the spray drying technique to produce microcapsules. chemical compounds of thyme oil and microcapsules were identified and quantified being thymol the chemical component present at the highest concentration. Oil-in-water (O/W) emulsions were prepared and the microcapsules were obtained with a spray dryer using maltodextrin as wall material (ratio 1:4)...
August 17, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
Elia Bari, Carla Renata Arciola, Barbara Vigani, Barbara Crivelli, Paola Moro, Giorgio Marrubini, Milena Sorrenti, Laura Catenacci, Giovanna Bruni, Theodora Chlapanidas, Enrico Lucarelli, Sara Perteghella, Maria Luisa Torre
Some natural compounds have recently been widely employed in wound healing applications due to their biological properties. One such compound is sericin, which is produced by Bombix mori, while active polyphenols, polysaccharides and proteins are synthetized by Chlorella vulgaris and Arthrospira platensis microalgae. Our hypothesis was that sericin, as an optimal bioactive polymeric carrier for microencapsulation process, could also improve the regenerative effect of the microalgae. A solvent-free extraction method and spray drying technique were combined to obtain five formulations, based on algal extracts (C...
August 23, 2017: Materials
K V Vishnu, Niladri S Chatterjee, K K Ajeeshkumar, R G K Lekshmi, C S Tejpal, Suseela Mathew, C N Ravishankar
Vanillic acid grafted chitosan (Va-g-Ch) was evaluated as a new antioxidant wall material for microencapsulation of polyunsaturated fatty acid rich sardine oil. A high grafting ratio of 305mg vanillic acid equivalent/g of polymer was achieved using a free radical mediated grafting reaction. Oil in water emulsion was prepared with an optimised combination of Va-g-Ch and Tween 20 (3.2:1). Sardine oil loaded microparticles (SO-M) were produced (∼75% yield) by spray drying. The average diameter and polydispersity Index (PDI) of the particles were found to be 2...
October 15, 2017: Carbohydrate Polymers
André Álvares Monge Neto, Rita de Cássia Bergamasco, Flávio Faria de Moraes, Antônio Medina Neto, Rosane Marina Peralta
This study focused on evaluating a technique for the psyllium husk mucilage (PHM) purification with simultaneous microencapsulation of curcumin. PHM was extracted with water and purified with ethanol. For the mucilage purification and simultaneous microencapsulation, an ethanolic solution of curcumin was used. After dehydration, the samples were analysed by instrumental techniques and evaluated for thermal stability. The presence of curcumin in the solution did not impair the yield of precipitated polysaccharide...
2017: PloS One
Diana P Gaspar, Maria Manuela Gaspar, Carla V Eleutério, Ana Grenha, Mateo Blanco, Lídia M D Gonçalves, Pablo Taboada, António J Almeida, Carmen Remuñán-López
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate their pulmonary delivery, the RFB-loaded SLN were included in microspheres of appropriate size using suitable excipients (mannitol and trehalose) through a spray-drying technique. Confocal analysis microscopy showed that microspheres are spherical and that SLN are efficiently microencapsulated and homogeneously distributed throughout the microsphere matrices...
August 15, 2017: Molecular Pharmaceutics
T P F Cabral, N C Bellini, K R Assis, C C C Teixeira, A D Lanchote, H Cabral, L A P de Freitas
The aim of this work was to obtain microencapsulated stable Aspergillus niger peptidases by post fermentation spray drying. The enzymatic extract was evaluated before and after spray drying microencapsulation to verify the effects of five different process parameters on the extract enzymatic activity, i.e. air flow, extract feed rate, drying temperature, homogenizing time and weight ratio of extract to encapsulation material. The optimal conditions were determined by desirability functions and experimentally confirmed...
August 14, 2017: Journal of Microencapsulation
Ki Hyun Kim, Tuan-Ho Le, Hee Kyung Oh, Bora Heo, Jeonghyun Moon, Sangmun Shin, Seong Hoon Jeong
Even though β-lapachone is a novel drug with pharmacological activity, it has limitations including instability under light conditions. The main purpose of the study was to enhance the stability of β-lapachone using the microencapsulation method. The Shirasu porous glass membrane was used to achieve uniform-sized microcapsules. The prepared microcapsules were evaluated to investigate how process parameters affect the encapsulation efficiency, photostability, and particle size distribution. The experimental design was conducted to obtain optimal formulations...
August 14, 2017: Journal of Microencapsulation
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