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https://www.readbyqxmd.com/read/28650996/whole-transcriptomic-and-proteomic-analyses-of-an-isogenic-m-tuberculosis-clinical-strain-with-a-naturally-occurring-15-kb-genomic-deletion
#1
Carla Duncan, Frances B Jamieson, JoLynn Troudt, Linda Izzo, Helle Bielefeldt-Ohmann, Angelo Izzo, Carolina Mehaffy
Tuberculosis remains one of the most difficult to control infectious diseases in the world. Many different factors contribute to the complexity of this disease. These include the ability of the host to control the infection which may directly relate to nutritional status, presence of co-morbidities and genetic predisposition. Pathogen factors, in particular the ability of different Mycobacterium tuberculosis strains to respond to the harsh environment of the host granuloma, which includes low oxygen and nutrient availability and the presence of damaging radical oxygen and nitrogen species, also play an important role in the success of different strains to cause disease...
2017: PloS One
https://www.readbyqxmd.com/read/28648713/zoonotic-infection-with-onchocerca-dewittei-japonica-in-an-11-year-old-boy-in-kansai-region-western-honshu-japan
#2
Shigehiko Uni, Masako Fukuda, Kou Ogawa, Yvonne Ai-Lian Lim, Takeshi Agatsuma, Naruemon Bunchom, Weerachai Saijuntha, Yasushi Otsuka, Subha Bhassu, Ahmad Syihan Mat Udin, Nur Afiqah Zainuri, Hasmahzaiti Omar, Jun Nakatani, Makoto Matsubayashi, Haruhiko Maruyama, Rosli Ramli, Mohd Sofian Azirun, Hiroyuki Takaoka
An 11-year-old boy living in Otsu City, Shiga Prefecture, Kansai Region, Western Honshu, Japan had zoonotic onchocercosis. The patient developed a painful swelling on the little finger of his left hand. The worm detected in the excised mass had external transverse ridges but did not have inner striae in the cuticle. On the basis of the parasite's histopathological characteristics, the causative agent was identified as a female Onchocerca dewittei japonica (Spirurida: Onchocercidae). The species of the filarial parasite was confirmed by sequencing the cox1 gene of the parasite...
June 22, 2017: Parasitology International
https://www.readbyqxmd.com/read/28647585/distribution-of-peanut-protein-in-school-and-home-environments-of-inner-city-children
#3
William J Sheehan, Helen A Brough, Kerry Makinson, Carter R Petty, Gideon Lack, Wanda Phipatanakul
Peanut protein was widely detectable in dust samples from school classrooms and cafeterias, with school levels higher than home levels, suggesting that schools may be an important place of exposure to food allergens in the environment.
June 21, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28647259/effect-of-current-emission-abatement-strategies-on-air-quality-improvement-in-china-a-case-study-of-baotou-a-typical-industrial-city-in-inner-mongolia
#4
Xionghui Qiu, Lei Duan, Siyi Cai, Qian Yu, Shuxiao Wang, Fahe Chai, Jian Gao, Yanping Li, Zhaoming Xu
The national Air Pollution Prevention and Control Action Plan required significant decreases in PM2.5 levels over China. To explore more effective emission abatement strategies in industrial cities, a case study was conducted in Baotou to evaluate the current national control measures. The total emissions of SO2, NOX, PM2.5 and NMVOC (non-methane volatile organic compounds) in Baotou were 211.2Gg, 156.1Gg, 28.8Gg, and 48.5Gg, respectively in 2013, and they would experience a reduction of 30.4%, 26.6%, 15.1%, and 8...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646963/spectrum-and-burden-of-dermatophytes-in-children
#5
Leila Ferguson, L Claire Fuller
Tinea capitis is the most important superficial fungal condition in children. It is often unrecognised but the presence of alopecia, scale and lymphadenopathy, especially in inner-city children should prompt investigation. An understanding of changing epidemiology and prevalence of causative organisms is important in deciding appropriate therapy. The use of diagnostic aids including dermoscopy is increasing and is reported to be helpful in identifying subtle signs. Trichophyton tonsurans accounts for the majority of cases in the UK and terbinafine is increasingly advocated as a safe and effective therapy...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28619649/the-school-inner-city-asthma-intervention-study-design-rationale-methods-and-lessons-learned
#6
Wanda Phipatanakul, Petros Koutrakis, Brent A Coull, Choong-Min Kang, Jack M Wolfson, Stephen T Ferguson, Carter R Petty, Mihail Samnaliev, Amparito Cunningham, William J Sheehan, Jonathan M Gaffin, Sachin N Baxi, Peggy S Lai, Perdita Permaul, Liming Liang, Peter S Thorne, Gary Adamkiewicz, Kasey J Brennan, Andrea A Baccarelli, Diane R Gold
Asthma is the most common chronic disease of childhood in the United States, causes significant morbidity, particularly in the inner-city, and accounts for billions of dollars in health care utilization. Home environments are established sources of exposure that exacerbate symptoms and home-based interventions are effective. However, elementary school children spend 7 to 12h a day in school, primarily in one classroom. From the observational School Inner-City Asthma Study we learned that student classroom-specific exposures are associated with worsening asthma symptoms and decline in lung function...
June 12, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28607943/poor-adherence-with-medication-refill-and-medical-supplies-maintenance-as-risk-factors-for-inpatient-asthma-admission-in-children
#7
Pavadee Poowuttikul, Benjamin Hart, Ronald Thomas, Elizabeth Secord
Background. Asthma results in significant pediatric hospitalizations in the inner city. Many asthmatic children were admitted to our hospital as a result of lack of medications or medical supplies that had been previously prescribed ("ran out," "broken," or "lost"). Objective. To identify the incidence of children admitted for asthma because of lack of prescribed medications/supplies and to assess risk factors for poor adherence between groups. Methods. This was a prospective chart review of 200 asthmatic children admitted to Children's Hospital of Michigan, Detroit...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28604792/characteristics-clinical-course-and-outcomes-of-homeless-and-non-homeless-patients-admitted-to-icu-a-retrospective-cohort-study
#8
Orla M Smith, Clarence Chant, Karen E A Burns, Maninder Kaur, Said Ashraf, Claudia C DosSantos, Stephen W Hwang, Jan O Friedrich
BACKGROUND: Little is known about homeless patients in intensive care units (ICUs). OBJECTIVES: To compare clinical characteristics, treatments, and outcomes of homeless to non-homeless patients admitted to four ICUs in a large inner-city academic hospital. METHODS: 63 randomly-selected homeless compared to 63 age-, sex-, and admitting-ICU-matched non-homeless patients. RESULTS: Compared to matched non-homeless, homeless patients (average age 48±12 years, 90% male, 87% admitted by ambulance, 56% mechanically ventilated, average APACHE II 17) had similar comorbidities and illness severity except for increased alcohol (70% vs 17%,p<0...
2017: PloS One
https://www.readbyqxmd.com/read/28601169/african-american-women-s-perceptions-on-access-to-food-and-water-in-flint-michigan
#9
Kellie E Mayfield, Marsha Carolan, Lorraine Weatherspoon, Kimberly R Chung, Sharon M Hoerr
OBJECTIVE: To explore the perceptions of food access by African American women in Flint, MI. METHODS: Using womanist theory, in which African American women's experiential knowledge centered the analysis, 8 focus groups were conducted during fall/spring, 2014-2015. Seventeen mothers aged 21-50 years with children aged <18 years and 13 women aged >60 years comprised the groups. RESULTS: The high cost of water, poor availability of healthy foods in inner-city stores, and limited transportation were barriers to accessing healthy food...
June 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28592584/utilising-advance-care-planning-videos-to-empower-perioperative-cancer-patients-and-families-a-study-protocol-of-a-randomised-controlled-trial
#10
Rebecca A Aslakson, Sarina R Isenberg, Norah L Crossnohere, Alison M Conca-Cheng, Ting Yang, Matthew Weiss, Angelo E Volandes, John F P Bridges, Debra L Roter
INTRODUCTION: Despite positive health outcomes associated with advance care planning (ACP), little research has investigated the impact of ACP in surgical populations. Our goal is to evaluate how an ACP intervention video impacts the patient centredness and ACP of the patient-surgeon conversation during the presurgical consent visit. We hypothesise that patients who view the intervention will engage in a more patient-centred communication with their surgeons compared with patients who view a control video...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28592287/naloxone-and-the-inner-city-youth-experience-nicye-a-community-based-participatory-research-study-examining-young-people-s-perceptions-of-the-bc-take-home-naloxone-program
#11
Keren Mitchell, S Elise Durante, Katrina Pellatt, Chris G Richardson, Steve Mathias, Jane A Buxton
BACKGROUND: Take home naloxone (THN) programs reduce mortality by training bystanders to respond to opioid overdoses. Clinical observation by the health care team at the Inner City Youth (ICY) program indicated that young adults appeared to enthusiastically participate in the THN program and developed improved relationships with staff after THN training. However, we found a dearth of literature exploring the experiences of young adults with THN programs. This study set out to address this gap and identify suggestions from the young adults for program improvement...
June 7, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28592241/effect-of-major-school-playground-reconstruction-on-physical-activity-and-sedentary-behaviour-camden-active-spaces
#12
Mark Hamer, Daniel Aggio, Georgina Knock, Courtney Kipps, Aparna Shankar, Lee Smith
BACKGROUND: The physical school environment is a promising setting to increase children's physical activity although robust evidence is sparse. We examined the effects of major playground reconstruction on physical activity and sedentary time in primary schools using a quasi-experimental design (comparison group pre-test/post-test design). METHODS: Five experimental and two control schools from deprived areas of inner city London were recruited at baseline. Main outcome was physical activity and sedentary time measured from objective monitoring (Actigraph accelerometer) at one year follow up...
June 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28584472/radiographic-anthropometric-study-of-frontal-sinus-for-sex-determination-in-benin-city-south-south-nigeria
#13
Dennis Erhisenebe O Eboh, Osesogie U Ogbeide, Theophilus Ivwighren
CONTEXT: The frontal sinuses are situated in the frontal bone between the outer and inner plates of the bone. A good knowledge on dimensions is relevant for successful surgery. AIM: This study was carried out to determine the dimorphic potential of the frontal sinuses and to ascertain the accuracy in sex determination using the logistic regression model among Edo people of Nigeria. MATERIALS AND METHODS: It was a 7 years retrospective study on the Edo, utilizing posterior-anterior radiographs of frontal sinuses in University of Benin Teaching Hospital...
January 2017: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28583955/progress-in-achieving-health-equity-requires-attention-to-root-causes
#14
Steven H Woolf
Life expectancy and disease rates in the United States differ starkly among Americans depending on their demographic characteristics and where they live. Although health care systems are taking important steps to reduce inequities, meaningful progress requires interventions outside the clinic, in sectors such as employment, housing, transportation, and public safety. Inequities exist in each of these sectors, and barriers to educational attainment, higher-income jobs, and social mobility limit the opportunity of disadvantaged people to improve their circumstances...
June 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28578217/still-at-risk-an-examination-of-how-street-involved-young-people-understand-experience-and-engage-with-harm-reduction-in-vancouver-s-inner-city
#15
Nikki Bozinoff, Will Small, Cathy Long, Kora DeBeck, Danya Fast
BACKGROUND: Vancouver is an international leader in implementing interventions to reduce harms related to drug use. However, street-involved young people who use drugs continue to be vulnerable to overdose death, hepatitis C (HCV) infection, and high rates of syringe sharing. To better understand this in the context of the intensive public health response, we examined how young people, who are involved in the 'street drug scene', understood, experienced and engaged with harm reduction...
June 1, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28570412/perceived-maternal-behavioral-control-infant-behavior-and-milk-supply-a-qualitative-study
#16
Elizabeth Peacock-Chambers, Kaitlin Dicks, Leela Sarathy, Allison A Brown, Renée Boynton-Jarrett
OBJECTIVE: Disparities persist in breastfeeding exclusivity and duration despite increases in breastfeeding initiation. The objective of this study was to examine factors that influence maternal decision making surrounding infant feeding practices over time in a diverse inner-city population. METHODS: We conducted a prospective qualitative study with 20 mothers recruited from 2 urban primary care clinics. Participants completed open-ended interviews and demographic questionnaires in English or Spanish administered at approximately 2 weeks and 6 months postpartum...
May 26, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28569291/misadventure-in-muirhouse-hiv-infection-a-modern-plague-and-persisting-public-health-problem
#17
R Robertson
This story is of particular interest and importance to Edinburgh and Scottish medicine. It describes the events in one general medical practice in Edinburgh, the Muirhouse Medical Group, and their impact and relationship to the AIDS pandemic. For many, the origin of HIV in the UK is now history. Since the introduction of HIV/AIDS into the intravenous illegal drug using community, much has changed but problems remain that should concern policy makers and clinicians. Reflections on the recent history of the HIV epidemic among drug users in the UK provide important insights into risks for current policy making and the potentially problematic direction that policy has taken...
March 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/28560613/the-relationship-between-neighborhood-disorder-social-networks-and-indoor-cigarette-smoking-among-impoverished-inner-city-residents
#18
Carl A Latkin, Tuo-Yen Tseng, Melissa Davey-Rothwell, Ryan D Kennedy, Meghan Bridgid Moran, Lauren Czaplicki, Catie Edwards, Oluwaseun Falade-Nwulia, Geetanjali Chander, Amy R Knowlton
Impoverished urban neighborhoods tend to have higher rates of smoking and higher rates of exposure to secondhand smoke as compared to more affluent neighborhoods. Contextual factors of neighborhood disorder and social network and household composition may have an impact on indoor smoking behaviors. The TIDE study examined psychosocial factors associated with smoking behaviors among impoverished inner-city smokers in Baltimore, Maryland. Among a community-recruited sample of 413 smokers who lived with others, most (73%) reported that they or others smoked in their residence...
May 30, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28560612/characterization-of-stress-in-low-income-inner-city-mothers-of-children-with-poorly-controlled-asthma
#19
Melissa H Bellin, Kathryn S Collins, Philip Osteen, Joan Kub, Mary Elizabeth Bollinger, Angelica Newsome, Cassie Lewis-Land, Arlene M Butz
The goal of this longitudinal analysis was to characterize factors associated with the experience of life stress in low-income, inner-city mothers of minority children with high-risk asthma.Participants (n = 276) reported on family demographics, child asthma control and healthcare utilization, social support, contemporary life difficulties (housing, finances, violence exposure) measured by the validated Crisis in Family Systems scale, and daily stress. Latent growth curve modeling examined predictors of life stress across 12 months as a function of home and community difficulties, asthma-specific factors, and social support...
May 30, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28555478/comparing-the-accuracy-of-food-outlet-datasets-in-an-urban-environment
#20
Michelle S Wong, Jennifer M Peyton, Timothy M Shields, Frank C Curriero, Kimberly A Gudzune
Studies that investigate the relationship between the retail food environment and health outcomes often use geospatial datasets. Prior studies have identified challenges of using the most common data sources. Retail food environment datasets created through academic-government partnership present an alternative, but their validity (retail existence, type, location) has not been assessed yet. In our study, we used ground-truth data to compare the validity of two datasets, a 2015 commercial dataset (InfoUSA) and data collected from 2012 to 2014 through the Maryland Food Systems Mapping Project (MFSMP), an academic-government partnership, on the retail food environment in two low-income, inner city neighbourhoods in Baltimore City...
May 11, 2017: Geospatial Health
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