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https://www.readbyqxmd.com/read/29776903/prolonged-survival-with-maintenance-pemetrexed-for-a-multiple-primary-malignancy
#1
Md Shuayb, Md Salim Reza
Despite the fact that multiple primary malignancies (MPMs) are not new and have been diagnosed for about a hundred-year time, literatures on lung and colon primaries are scarce. We report a case of a 62-year-old Asian Bangladeshi man with stage IV lung adenocarcinoma who developed a metachronous stage II colon adenocarcinoma approximately 3 years later. A chemotherapy protocol of six cycles of pemetrexed/cisplatin followed by maintenance pemetrexed was used, and surgery was done for the colon primary. With more than 5 years of periodic follow-up, his disease remains stable without any local or metastatic recurrence...
May 18, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29775662/multivoxel-pattern-similarity-suggests-the-integration-of-temporal-duration-in-hippocampal-event-sequence-representations
#2
Sathesan Thavabalasingam, Edward B O'Neil, Andy C H Lee
Recent rodent work suggests the hippocampus may provide a temporal representation of event sequences, in which the order of events and the interval durations between them are encoded. There is, however, limited human evidence for the latter, in particular whether the hippocampus processes duration information pertaining to the passage of time rather than qualitative or quantitative changes in event content. We scanned participants while they made match/mismatch judgements on each trial between a study sequence of events and a subsequent test sequence...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29775623/unsupervised-visual-discrimination-learning-of-complex-stimuli-accuracy-bias-and-generalization
#3
Rodrigo Montefusco-Siegmund, Mauricio Toro, Pedro E Maldonado, María de la L Aylwin
Through same-different judgements, we can discriminate an immense variety of stimuli and consequently, they are critical in our everyday interaction with the environment. The quality of the judgements depends on familiarity with stimuli. A way to improve the discrimination is through learning, but to this day, we lack direct evidence of how learning shapes the same-different judgments with complex stimuli. We studied unsupervised visual discrimination learning in 42 participants, as they performed same-different judgments with two types of unfamiliar complex stimuli in the absence of labeling or individuation...
May 15, 2018: Vision Research
https://www.readbyqxmd.com/read/29773703/investigating-admitted-patients-satisfaction-with-nursing-care-at-debre-berhan-referral-hospital-in-ethiopia-a-cross-sectional-study
#4
Nigussie Tadesse Sharew, Hailegiorgis Teklegiorgis Bizuneh, Hilina Ketema Assefa, Tesfa Dejenie Habtewold
OBJECTIVES: The aims of the study were (1) to assess the level of patient satisfaction with nursing care and (2) to identify factors influencing patient satisfaction. DESIGN: A hospital-based, cross-sectional study was conducted with 252 admitted patients in the medical, surgical and paediatric wards. SETTING: Debre Berhan Referral Hospital, Debre Berhan, Ethiopia, with a catchment population of 2.8 million. PARTICIPANTS: All patients admitted at least for 2 days and capable of independent communication were included...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29773611/charlie-gard-and-the-weight-of-parental-rights-to-seek-experimental-treatment
#5
Giles Birchley
The case of Charlie Gard, an infant with a genetic illness whose parents sought experimental treatment in the USA, brought important debates about the moral status of parents and children to the public eye. After setting out the facts of the case, this article considers some of these debates through the lens of parental rights. Parental rights are most commonly based on the promotion of a child's welfare; however, in Charlie's case, promotion of Charlie's welfare cannot explain every fact of the case. Indeed, some seem most logically to extend from intrinsic parental rights, that is, parental rights that exist independent of welfare promotion...
May 17, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29773084/sexual-and-reproductive-health-concerns-of-persons-with-disability-in-india-an-issue-of-deep-rooted-silence
#6
Seema Sharma, Muthusamy Sivakami
SummaryGlobal estimates suggest that over a billion people live with a disability that is significant enough to affect their daily lives. According to the 2011 Indian Census, India alone has about 26.8 million people with disabilities. Research suggests that persons with disabilities (PwDs) in India are among the most neglected, stigmatized, poor and least educated of the world's population, and women with disabilities in India are the most marginalized, both socially and economically. They bear the triple burden of being discriminated against through being 'women' (socially marginal beings), 'disabled' (incapacitated, inefficient and undesirable) and 'women with disabilities' (the weakest of the weak), often becoming socially invisible...
May 18, 2018: Journal of Biosocial Science
https://www.readbyqxmd.com/read/29771249/-new-italian-law-about-end-of-life-self-determination-and-shared-care-pathway
#7
Rosagemma Ciliberti, Matteo Gulino, Ilaria Gorini
The Italian Parliament has recently approved the Law n. 219/2017 concerning "Rules on informed consent and advance directives". The manuscript points out the main key points of the new law, in order to clarify the role of the advance directives and to provide clear operational guidelines for healthcare personnel. Taking into consideration the Italian deontological and juridical context, along with the main jurisprudential judgements, the law has been analysed. The Authors discussed the new rules and the bioethical issues also in relation to the provisions stated by the Convention on Human Rights and Biomedicine (Convention of Oviedo)...
May 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29770054/new-vaccine-administration-practice-recommendations-from-the-canadian-immunization-guide
#8
C Jensen, D Moore, C Mah, O Baclic, S Marchant-Short
Background: The Canadian Immunization Guide (CIG) is published online by the Public Health Agency of Canada and summarizes guidance on vaccines for human use into a single resource. Chapters are reviewed and updated on a regular basis. Vaccine administration is a critical part of any immunization program. Recently, the CIG chapter on vaccine administration practices was updated. Objective: To provide highlights of recent changes to the Vaccine Administration Practices chapter of the CIG...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769414/clinical-utility-of-arterial-spin-labeling-for-preoperative-grading-of-glioma-a-diagnostic-meta-analysis
#9
Linchen Li, Xinjun Wang, Min Zhang, Yan Zhang
There were obvious differences in biological behavior and prognosis between low-grade glioma and high-grade glioma, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through November 10, 2017 and used "arterial spin-labeling" OR "ASL perfusion, grading" OR "differentiation, glioma" OR "glial tumor, diagnostic test" as the search terms...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29767459/long-term-effects-of-patiromer-for-hyperkalaemia-treatment-in-patients-with-mild-heart-failure-and-diabetic-nephropathy-on-angiotensin-converting-enzymes-angiotensin-receptor-blockers-results-from-amethyst-dn
#10
Bertram Pitt, George L Bakris, Matthew R Weir, Mason W Freeman, Mitja Lainscak, Martha R Mayo, Dahlia Garza, Rezi Zawadzki, Lance Berman, David A Bushinsky
AIMS: Chronic kidney disease (CKD) in heart failure (HF) increases the risk of hyperkalaemia (HK), limiting angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB) use. Patiromer is a sodium-free, non-absorbed potassium binder approved for HK treatment. We retrospectively evaluated patiromer's long-term safety and efficacy in HF patients from AMETHYST-DN. METHODS AND RESULTS: Patients with Type 2 diabetes, CKD, and HK [baseline serum potassium >5...
May 16, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29755721/effects-of-congruent-and-incongruent-stimulus-colour-on-flavour-discriminations
#11
Leonie Wieneke, Pauline Schmuck, Julia Zacher, Mark W Greenlee, Tina Plank
In addition to gustatory, olfactory and somatosensory input, visual information plays a role in our experience of food and drink. We asked whether colour in this context has an effect at the perceptual level via multisensory integration or if higher level cognitive factors are involved. Using an articulatory suppression task, comparable to Stevenson and Oaten, cognitive processes should be interrupted during a flavour discriminatory task, so that any residual colour effects would be traceable to low-level integration...
March 2018: I-Perception
https://www.readbyqxmd.com/read/29754596/sharing-solutions-for-a-reasoned-and-evidence-based-response-chemsex-party-and-play-among-gay-and-bisexual-men
#12
Adam Bourne, Jason Ong, Mark Pakianathan
This Special Issue of Sexual Health examines research and healthcare practice relating to sexualised drug use among gay, bisexual and other men who have sex with men (GBMSM), colloquially known as 'chemsex' or 'party and play' (PnP). It draws together evidence relating to the epidemiology, sociology and psychology of chemsex, as well as the policy, community and clinical interventions that are required to ensure men have access to high-quality health care that meets their needs and reduces harm. Findings and discussions within the Issue emphasise the need to sensitively, non-judgementally and meaningfully engage with gay men about their engagement in chemsex in order to help improve their sexual health and wider wellbeing...
April 2018: Sexual Health
https://www.readbyqxmd.com/read/29754583/validity-evidence-for-the-hamburg-multiple-mini-interview
#13
Mirjana Knorr, Anja Schwibbe, Maren Ehrhardt, Janina Lackamp, Stefan Zimmermann, Wolfgang Hampe
BACKGROUND: Multiple mini-interviews (MMI) become increasingly popular for the selection of medical students. In this work, we examine the validity evidence for the Hamburg MMI. METHODS: We conducted three follow-up studies for the 2014 cohort of applicants to medical school over the course of two years. We calculated Spearman's rank correlation (ρ) between MMI results and (1) emotional intelligence measured by the Trait Emotional Intelligence Questionnaire (TEIQue-SF) and the Situational Test of Emotion Management (STEM), (2) supervisors' and practice team members' evaluations of psychosocial competencies and suitability for the medical profession after a one-week 1:1 teaching in a general practice (GP) and (3) objective structured clinical examination (OSCE) scores...
May 14, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29754403/-one-size-does-not-fit-all-perspectives-on-diversity-in-community-aged-care
#14
Claudia Meyer, Arti Appannah, Sally McMillan, Colette Browning, Rajna Ogrin
OBJECTIVES: Typically, older people are viewed via a single health condition, yet health outcomes are likely impacted by the intersection of many individual characteristics. Promoting inclusive health care is underpinned by reducing bias, respectful communication and supporting individual needs and preferences. This study explores perspectives of community aged care workers on diversity training and implementing training into practice. METHODS: Ninety community aged care workers were telephone-interviewed three months after a one-day diversity training workshop...
May 13, 2018: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29753436/-occupational-therapy-and-eating-disorders-a-care-case-study
#15
REVIEW
Charline Vermeersch
Occupational therapy offers support through actuation via a suggested activity. It opens up a differentiated space, a space of experiences where patients can contemplate themselves through play. The therapeutic relationship, assured by the occupational therapist, offers flexibility and malleability to welcome, contain and support the person with an eating disorder. It aims to be compassionate without judgement to favour the experience of movement. 'Making do with oneself' to 'be with oneself' while respecting the temporality of the patient's possibilities...
May 2018: Soins. Psychiatrie
https://www.readbyqxmd.com/read/29752213/-when-no-one-s-looking-the-application-of-lung-recruitment-and-normal-saline-instillation-with-paediatric-endotracheal-suction-an-exploratory-study-of-nursing-practice
#16
Jessica A Schults, Marie Cooke, Debbie Long, Marion L Mitchell
BACKGROUND: The complex nature of the Paediatric Intensive Care Unit (PICU) patient requires the bedside nurse to make rapid, complex decisions regarding endotracheal suction (ETS) interventions. It is not understood what influences nurses' decision making in the context of ETS, however, the actions of the clinician have a direct impact on the efficacy of the ETS event and patient outcomes. OBJECTIVES: To explore and describe the use of normal saline instillation and lung recruitment with paediatric ETS in a cohort of Australian nurses, and to identify factors that influence normal saline use with ETS...
May 8, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29750096/three-dimensional-reliability-analyses-of-currently-used-methods-for-assessment-of-sagittal-jaw-discrepancy
#17
Bushra-Sufyan Almaqrami, Maged-Sultan Alhammadi, BaoChang Cao
Background: The objective of this study was to analyse three dimensionally the reliability and correlation of angular and linear measurements in assessment of anteroposterior skeletal discrepancy. Material and Methods: In this retrospective cross sectional study, a sample of 213 subjects were three-dimensionally analysed from cone-beam computed tomography scans. The sample was divided according to three dimensional measurement of anteroposterior relation (ANB angle) into three groups (skeletal Class I, Class II and Class III)...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29746012/exploring-the-influence-of-feedback-given-by-people-with-lived-experience-of-mental-distress-on-learning-for-pre-registration-mental-health-students
#18
Gemma Stacey, Mark Pearson
INTRODUCTION: Despite a positive and established perception of people with lived experience of mental distress contributing to the assessment of healthcare professionals, the consequence and implications for learning are predominantly unexplored. AIM: To gain a greater understanding of the influence of feedback given by people with lived experience, in the role of formative assessor, on student learning. METHOD: Qualitative analysis, underpinned by the theory threshold concepts, was conducted on the written reflective assessments, submitted by students, following engaging in an assessment with a lived experience assessor...
May 10, 2018: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29745853/a-new-method-to-measure-the-semantic-similarity-from-query-phenotypic-abnormalities-to-diseases-based-on-the-human-phenotype-ontology
#19
Xiaofeng Gong, Jianping Jiang, Zhongqu Duan, Hui Lu
BACKGROUND: Although rapid developed sequencing technologies make it possible for genotype data to be used in clinical diagnosis, it is still challenging for clinicians to understand the results of sequencing and make correct judgement based on them. Before this, diagnosis based on clinical features held a leading position. With the establishment of the Human Phenotype Ontology (HPO) and the enrichment of phenotype-disease annotations, there throws much more attention to the improvement of phenotype-based diagnosis...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29742545/perceptual-discrimination-of-speaking-style-under-cochlear-implant-simulation
#20
Terrin N Tamati, Esther Janse, Deniz Başkent
OBJECTIVES: Real-life, adverse listening conditions involve a great deal of speech variability, including variability in speaking style. Depending on the speaking context, talkers may use a more casual, reduced speaking style or a more formal, careful speaking style. Attending to fine-grained acoustic-phonetic details characterizing different speaking styles facilitates the perception of the speaking style used by the talker. These acoustic-phonetic cues are poorly encoded in cochlear implants (CIs), potentially rendering the discrimination of speaking style difficult...
May 9, 2018: Ear and Hearing
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