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https://www.readbyqxmd.com/read/28635983/risk-factors-for-re-excision-following-breast-conserving-surgery
#1
Kimberly Rodriguez, Gayle G Wilkins, Patricia Newcomb, Patricia A Gwirtz, Robin Skrine
PURPOSE/OBJECTIVES: To identify previously unstudied factors predicting re-excision following breast-conserving surgery (BCS) and to assess the feasibility of obtaining data about breast density for predictive modeling.
. DESIGN: Retrospective secondary data analysis.
. SETTING: Data were obtained from the cancer registry and electronic health records (EHRs) at Texas Health Harris Methodist Hospital, a large, urban, private, nonprofit hospital in North Texas...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28632240/body-related-shame-and-guilt-predict-physical-activity-in-breast-cancer-survivors-over-time
#2
Andrée L Castonguay, Carsten Wrosch, Eva Pila, Catherine M Sabiston
PURPOSE/OBJECTIVES: To test body-related shame and guilt as predictors of breast cancer survivors' (BCS') moderate to vigorous intensity physical activity (MVPA) during six months and to examine motivational regulations as mediators of this association.
. DESIGN: Prospective study.
. SETTING: Survivors were recruited through advertisements and oncologist referrals from medical clinics and hospitals in Montreal, Quebec, Canada.
. SAMPLE: 149 female BCS...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28631134/budd-chiari-syndrome-outcomes-of-endovascular-intervention-a-single-center-experience
#3
Nitin Jagtap, Mithun Sharma, Jagdeesh Singh, Manu Tandan, P N Rao, Rajesh Gupta, Sundeep Lakhtakia, Mohan Ramchandani, Harshal Shah, T Mahesh Kumar, Santosh Darishetty, G V Rao, D N Reddy
AIM: Outcomes of endovascular intervention in Budd-Chiari syndrome (BCS) have been reported with varied results. Clinical outcomes of endovascular interventions in BCS and role of various prognostic scores were critically evaluated in this study. METHODS: This study retrospectively analyzed consecutive patients of BCS who underwent endovascular intervention between January 2007 and May 2016 at our center. Technical, clinical successes and complications were documented...
June 20, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28630703/energy-requirements-for-growth-in-the-yorkshire-terrier
#4
Janet E Alexander, Alison Colyer, Penelope J Morris
The 2006 National Research Council (NRC) equation calculating puppy energy requirements does not account for reported breed differences in growth pattern. Energy requirements of toy breed puppies are unknown and it is unclear whether feeding guidelines should differ between breeds. Energy requirements of Yorkshire terrier (YT) puppies were observed over their first year of life and compared with those predicted by the NRC and those previously observed in large (Labrador retriever) and medium (miniature Schnauzer; MS) breed puppies...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28630697/the-effect-of-position-on-the-precision-of-dual-energy-x-ray-absorptiometry-and-correlation-with-body-condition-score-in-dogs-and-cats
#5
Charlotte R Bjørnvad, Mie E Nielsen, Susanna E M Hansen, Dorte H Nielsen
Dual-energy X-ray absorptiometry (DEXA) has been used to assess body composition in dogs and cats in several studies, but studies are difficult to compare for several reasons. The aim of the present study was to evaluate whether positioning of dogs or cats in either dorsal or ventral recumbency during DEXA scanning influences results. Dogs and cats that were brought to the University Hospital for Companion Animals for euthanasia during the period 15 September-6 November 2015 were consecutively recruited if owners signed a written consent...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28630696/the-impact-of-time-of-neutering-on-weight-gain-and-energy-intake-in-female-kittens
#6
David Allaway, Matthew Gilham, Alison Colyer, Penelope J Morris
Neutering is a risk factor for obesity in companion animals. In a study to determine the total energy requirements of kittens (15-52 weeks) the impact of neutering and age when neutered on intake and body weight (BW) was investigated. Females (n 14), neutered when 19 (early neuter; EN) or 31 (conventional neuter; CN) weeks old (n 7/group), were individually fed to maintain an ideal body condition score (BCS). EN kittens gained weight gradually whilst CN kittens' BW gain slowed from week 24, weighing less than EN kittens from week 30 with a reduced energy intake (kcal/kg BW(0·67)) in weeks 24-32 (P < 0·05)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28630301/potential-high-tc-superconducting-lanthanum-and-yttrium-hydrides-at-high-pressure
#7
Hanyu Liu, Ivan I Naumov, Roald Hoffmann, N W Ashcroft, Russell J Hemley
A systematic structure search in the La-H and Y-H systems under pressure reveals some hydrogen-rich structures with intriguing electronic properties. For example, LaH10 is found to adopt a sodalite-like face-centered cubic (fcc) structure, stable above 200 GPa, and LaH8 a C2/m space group structure. Phonon calculations indicate both are dynamically stable; electron phonon calculations coupled to Bardeen-Cooper-Schrieffer (BCS) arguments indicate they might be high-Tc superconductors. In particular, the superconducting transition temperature Tc calculated for LaH10 is 274-286 K at 210 GPa...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629571/detection-and-characterization-of-budd-chiari-syndrome-with-inferior-vena-cava-obstruction-comparison-of-fixed-and-flexible-delayed-scan-time-of-computed-tomography-venography
#8
Peng-Li Zhou, Gang Wu, Xin-Wei Han, Yong-Hua Bi, Wen-Guang Zhang, Zheng-Yang Wu
PURPOSE: To compare the results of computed tomography venography (CTV) with a fixed and a flexible delayed scan time for Budd-Chiari syndrome (BCS) with inferior vena cava (IVC) obstruction. MATERIAL AND METHODS: A total of 209 consecutive BCS patients with IVC obstruction underwent either a CTV with a fixed delayed scan time of 180s (n=87) or a flexible delayed scan time for good image quality according to IVC blood flow in color Doppler ultrasonography (n=122)...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28627469/modeling-and-comparison-of-release-profiles-effect-of-the-dissolution-method
#9
Sara Cascone
During the last decades, the study of the in vitro dissolution of pharmaceuticals has been strongly encouraged by the FDA in order to determine its relationship with the in vivo bioavailability of a drug. In this work immediate and extended release formulations containing diclofenac, a BCS class II drug, were studied using different dissolution methods. The release profiles obtained in USP Apparatus II and USP Apparatus IV were evaluated and compared to determine the effect of the fluid dynamic conditions on the release...
June 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28627060/clinical-nutrition-counselling-service-in-the-veterinary-hospital-retrospective-analysis-of-equine-patients-and-nutritional-considerations
#10
D Vergnano, D Bergero, E Valle
Nutrition plays a very important role in the healthy and in the ill horse. Although research in this field clearly shows that incorrect nutritional practices may lead to severe pathologies, inappropriate feeding plans often continue to be used. A clinical nutrition counselling (CNC) service could thus be of great use to both horse owners and veterinarians. The aim of this study was to provide information on equine patients referred to the CNC service of the University of Turin and to provide standard dietary protocols as used in our Veterinary Teaching Hospital for the most common nutrition-related pathologies...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28627058/survey-nutrition-body-condition-and-activities-of-dogs-in-switzerland
#11
K Gerstner, A Liesegang
Interest in species-appropriate activities and nutrition of dogs increases. A huge variety of feedstuff available, myths and different feeding theories confuse dog owners and lead to inadequate nutrition of their pets. As one result, obesity in pets can be observed with a high incidence in veterinary practice. Although comorbidities of obesity are well known, only few pet owners realize consequently the necessity of weight reduction to support their pet's health. We hypothesized that pet owners in Switzerland underestimate body condition of their dogs and are unsure about how to manage nutritional challenges...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28622790/early-life-risk-factors-identified-for-owner-reported-feline-overweight-and-obesity-at-around-two-years-of-age
#12
E C Rowe, W J Browne, R A Casey, T J Gruffydd-Jones, J K Murray
Obesity is considered the second most common health problem in pet cats in developed countries. This study used prospective data from a longitudinal study of pet cats ('C.L.A.W.S.', www.bristol.ac.uk/vetscience/claws) to identify early-life risk factors for feline overweight/obesity occurring at around two years of age. Data were collected via five owner-completed questionnaires (for cats aged two-six months, six months, 12 months, 18 months and two years respectively) completed between May 2011 and April 2015...
August 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28621952/gastrointestinal-and-systemic-disposition-of-diclofenac-under-fasted-and-fed-state-conditions-supporting-the-evaluation-of-in-vitro-predictive-tools
#13
Jens Van Den Abeele, Ronald Schilderink, FElix Schneider, Raf Mols, Mans Minekus, Werner Weitschies, Joachim Brouwers, Jan Tack, Patrick Augustijns
This study aimed to gain further insight into the gastrointestinal disposition of the weakly acidic BCS Class II drug diclofenac and the implications for systemic drug exposure in humans under fasted and fed state conditions. For this purpose, gastrointestinal and blood samples were collected from healthy volunteers after oral intake of a commercially available tablet of the potassium salt of diclofenac (i.e. Cataflam®) in different prandial states. Subsequently, these in vivo data served as a reference for the evaluation of in vitro tools with different levels of complexity, i...
June 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28619755/epidermal-growth-factor-receptor-egfr-targeted-photoimmunotherapy-pit-for-the-treatment-of-egfr-expressing-bladder-cancer
#14
Reema Railkar, L Spencer Krane, Q Quentin Li, Thomas Sanford, Mohammad Rashid Siddiqui, Diana Haines, Srinivas Vourganti, Sam J Brancato, Peter L Choyke, Hisataka Kobayashi, Piyush K Agarwal
The use of light as a means of therapy for bladder cancer (BC) has a long history but has been hampered by a lack of tumor specificity and therefore, damage to the normal bladder mucosa. Here, we describe a targeted form of photo-therapy called photoimmunotherapy (PIT) which targets EGFR-expressing BC. Anti-EGFR antibody panitumumab (pan) was labeled with the photo-absorber (PA), IRDye 700Dx (IR700), to create a pan IR700 antibody-PA conjugate which is activated by near-infrared radiation (NIR). BC tissue microarray (TMA) and BC cell lines were analyzed for expression of EGFR...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28611538/breast-conserving-surgery-under-local-anesthesia-in-elderly-patients-with-severe-cardiorespiratory-comorbidities-a-hospital-based-case-control-study
#15
Hasan Karanlik, Berkay Kılıç, Ilknur Yıldırım, Süleyman Bademler, Ilker Ozgur, Burak Ilhan, Semen Onder
INTRODUCTION: We report the feasibility and safety of local anesthesia (LA) in patients having breast-conserving surgery (BCS). METHODS: 37 patients with American Society of Anesthesiologists (ASA) score of 4 having BCS under LA and 54 age-matched subjects with ASA score of 3-4 having BCS under general anesthesia (GA) were included. Patients were retrospectively evaluated for the follow-up duration, duration of surgery, postoperative satisfaction scores (1-10), complication and survival time for locoregional recurrence and overall survival rates...
March 2017: Breast Care
https://www.readbyqxmd.com/read/28610410/prognostic-value-of-clinicopathological-factors-for-indonesian-breast-carcinomas-of-different-molecular-subtypes
#16
Irianiwati Widodo, Ery Kus Dwianingsih, Sumadi Lukman Anwar, Triningsih Fx Ediati, Totok Utoro, Teguh Aryandono, Soeripto
Background: Breast carcinoma (BC) is a heterogeneous disease due to its different molecular profiles i.e. luminal (luminal A and luminal B) and non-luminal (HER2 positive and triple negative) subtypes. Prognostic value of clinicopathological factors of Indonesian BC of different molecular subtypes has never been reported previously. This study aims to elaborate prognostic impacts on Indonesian BCs focusing on separate molecular subtypes. Methods: A hundred and fifty cases of invasive BC, stage I-IIIA, in Sardjito Hospital, Indonesia, were stained using anti ER, PR, HER2 and Ki-67 antibodies...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28599693/clinical-characteristics-and-outcome-of-budd-chiari-syndrome-at-a-tertiary-care-hospital-in-pakistan
#17
Om Parkash, Aysha Khan, Saeed Hamid
OBJECTIVE: To determine the clinical characteristics of Budd-Chiari syndrome (BCS), its causes and outcome at a tertiary care hospital. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: The Aga Khan University Hospital,Karachi, from 2004 to 2014. METHODOLOGY: Aretrospective analysis of data was conducted. Apredesigned questionnaire was filled from medical records of patients with BCS. Clinical features, etiology, management and outcome was noted from 2004 to 2014...
May 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28597470/breast-conservation-for-male-breast-cancer-case-report-of-intraoperative-radiation
#18
Ameer Gomberawalla, Peter Liou, Rebecca Martinez, Raj Rajpara, Eileen Connolly, David Horowitz, Sheldon Feldman
Male breast cancer (MBC) comprises <1% of all breast cancers in the United States. MBC is typically treated with total mastectomy while the majority of female breast cancer is treated with breast conservation therapy combined with various forms of radiation. One method that has developed over the last two decades is the use of intraoperative radiation therapy (IORT) as a type of accelerated partial breast irradiation to direct the treatment field to the tumor bed. Since overall prognosis and systemic therapy recommendations for MBC are similar to breast cancer in women, we describe the first case of MBC treated with BCS and IORT...
June 8, 2017: Breast Journal
https://www.readbyqxmd.com/read/28596138/preparation-characterization-and-cytotoxicity-studies-of-niclosamide-loaded-mesoporous-drug-delivery-systems
#19
Vishwas Pardhi, Rahul B Chavan, Rajesh Thipparaboina, Sowjanya Thatikonda, Vgm Naidu, Nalini R Shastri
Recent reports on the anticancer potential of niclosamide have opened new avenues for anticancer treatment. Niclosamide belongs to the BCS class II, which is indicative of poor solubility and dissolution rate limited absorption. The aim of this study was to improve the dissolution rate of the drug by mesoporous drug delivery system. Porous silica grades (ordered and nonordered) with different pore size, pore volume and surface area were used in the study. The drug was loaded on silica carriers by the solvent evaporation method and characterized by BET surface area analysis, SEM, P-XRD, DSC, and FTIR...
June 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28595965/low-expression-of-estrogen-receptor-%C3%AE-and-progesterone-receptor-in-human-breast-cancer-tissues-is-associated-with-high-grade-human-cytomegalovirus-protein-expression
#20
Afsar Rahbar, Joel Touma, Helena Costa, Belghis Davoudi, Ida Rashid Bukholm, Torill Sauer, Katja Vetvik, Jürgen Geisler, Cecilia Söderberg-Naucler
BACKGROUND: The underlying mechanisms for breast cancer (BC) are largely unknown. We investigated possible correlations between the expression levels of human cytomegalovirus (HCMV) proteins and established histopathological markers of BC, including expression of estrogen receptor (ER)-α, the progesterone receptor (PgR), and HER2. MATERIALS AND METHODS: We retrospectively examined paraffin-embedded biopsy specimens of BC (n = 62), ductal carcinoma in situ (n = 19), and adjacent normal breast tissue (n = 42) for HCMV immediate-early protein (IE), HCMV late antigen, HCMV DNA and RNA, and investigated possible correlations between them and expression of ER-α, PgR, and HER2...
May 11, 2017: Clinical Breast Cancer
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