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https://www.readbyqxmd.com/read/28525343/changes-of-hematological-and-biochemical-parameters-and-levels-of-pepsinogen-histamine-and-prostaglandins-in-dairy-cows-affected-with-left-displacement-of-the-abomasum
#1
O Al-Rawashdeh, Z Bani Ismail, A Talafha, A Al-Momani
The aims of this study were to determine the serum levels of pepsinogen, histamine, and prostaglandins F2α and E2 in lactating dairy cows affected with left displacement of the abomasum (LDA). In addition, the hematological and serum biochemical parameters were also determined in cows affected with LDA. A total of 52 adult lactating Holstein-Friesian cows affected with LDA and 30 normal cows (control) were used. In LDA cows, the average age, BCS and body weight were 4.9 ± 1.2 years, 2.5 ± 0.75, and 525 ± 150kg respectively...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28517238/flen-and-fleq-play-a-synergistic-role-in-regulating-lapa-and-bcs-operons-in-pseudomonas-putida-kt2440
#2
Hailing Nie, Yujie Xiao, Huizhong Liu, Jinzhi He, Wenli Chen, Qiaoyun Huang
FleN generally functions as an antagonist of FleQ in regulating flagellar genes and biofilm matrix related genes in Pseudomonas aeruginosa. Here we found that in Pseudomonas putida KT2440, FleN and FleQ play a synergistic role in regulating two biofilm matrix coding operons, lapA and bcs. FleN deletion decreased transcription of lapA and increased transcription of bcs operon, the same trend was observed in fleQ deletion mutant before. In vitro experiments showed that FleN promoted binding of FleQ to the lapA/bcs promoter DNA especially in the presence of ATP...
May 18, 2017: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/28516414/optimized-mucoadhesive-coated-niosomes-as-a-sustained-oral-delivery-system-of-famotidine
#3
Al-Zahraa M Khalifa, Bazigha K Abdul Rasool
The objective of this study is to develop an oral formulation of famotidine niosomes coated with a mucoadhesive polymer, chitosan. Famotidine (FMT) has low oral bioavailability of 40-45% and short half-life between 2.5 to 4 h. Famotidine is classified as class IV in BCS because of its low aqueous solubility (0.1% w/v) and low permeability. Thus, FMT was loaded to the bioadhesive coated niosomes to improve its solubility, enhance its oral bioavailability, and sustain FMT release pattern. Different formulations were prepared by thin-film hydration method and characterized in terms of entrapment efficiency, morphological features, vesicle size, and zeta potential...
May 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28516359/evolution-of-choice-of-solubility-and-dissolution-media-after-two-decades-of-biopharmaceutical-classification-system
#4
Nadia Bou-Chacra, Katherine Jasmine Curo Melo, Ivan Andrés Cordova Morales, Erika S Stippler, Filippos Kesisoglou, Mehran Yazdanian, Raimar Löbenberg
The introduction of the biopharmaceutics drug classification system (Biopharmaceutics Classification System (BCS)), in 1995, provided a simple way to describe the biopharmaceutics behavior of a drug. Solubility and permeability are among the major parameters, which determine the fraction dose absorbed of a drug substance and consequently its chances to be bioavailable. The purpose of this review is to summarize the evolution of the media used for determining solubility and dissolution and how this can be used in modern drug development...
May 17, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28515446/phase-channel-dynamics-reveal-the-role-of-impurities-and-screening-in-a-quasi-one-dimensional-charge-density-wave-system
#5
M D Thomson, K Rabia, F Meng, M Bykov, S van Smaalen, H G Roskos
Charge density waves (CDWs), i.e. the periodic spatial modulation of coupled electronic and lattice density, are ubiquitous in low-dimensional conductors and have taken on renewed relevance due their role in state-of-the-art materials, e.g. high-T c superconductors, topological insulators and low-dimensional carbon. As CDWs are described by a complex order parameter to represent both the amplitude and phase, they are formally analogous to BCS superconductors and spin-waves, providing a prototype of collective phenomena for the further development of field theories and ab-initio calculations of complex solids...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514945/tumor-volume-to-breast-volume-ratio-for-improving-cosmetic-results-in-breast-cancer-patients-turacos-a-randomized-controlled-trial
#6
M Lagendijk, E L Vos, A H J Koning, M G M Hunink, J P Pignol, E M L Corten, C de Monye, C H M van Deurzen, J H van Dam, W W Vrijland, C M E Contant, C Verhoef, W van Lankeren, L B Koppert
BACKGROUND: Cosmetic result following breast conserving surgery (BCS) for cancer influences quality of life and psychosocial functioning in breast cancer patients. A preoperative prediction of expected cosmetic result following BCS is not (yet) standard clinical practice and therefore the choice for either mastectomy or BCS is still subjective. Recently, we showed that tumour volume to breast volume ratio as well as tumour location in the breast are independent predictors of superior cosmetic result following BCS...
May 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28512394/successful-endoscopic-management-of-late-biliary-cast-syndrome-in-a-liver-transplant-recipient-a-case-report
#7
Manuel Alejandro Mahler, Federico Marcaccio, Jean-Marc Dumonceau, Carlos Macías Gómez
Biliary cast syndrome (BCS) is an unusual complication of liver transplantation (LT). The pathophysiology is not known, and it is thought to develop because of mucosal damage in the bile duct related to obstruction, ischemia, or bacterial infection. It occurs in 2.5-18% of LT patients and is associated with increased graft failure, need for retransplantation, and mortality. Here we report on a case of BCS of late appearance after LT who was successfully treated by endoscopic means.
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28505346/breast-cancer-screening-bcs-chart-a-basic-and-preliminary-model-for-making-screening-mammography-more-productive-and-efficient
#8
Jalal Poorolajal, Mohammad Esmaeil Akbari, Fatane Ziaee, Manoochehr Karami, Mahshid Ghoncheh
BACKGROUND: The breast cancer screening (BCS) chart is suggested as a basic and preliminary tool to improve efficiency of screening mammography. METHODS: We conducted this case-control study in 2016 and enrolled 1422 women aged 30-75 years, including 506 women with breast cancer (cases) and 916 women without breast cancer (controls). We developed the BCS chart using a multiple logistic regression analysis. We combined the risks of breast cancer to predict the individual risk of breast cancer...
May 15, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28503673/non-fermi-liquid-behavior-in-quantum-impurity-models-with-superconducting-channels
#9
Rok Žitko, Michele Fabrizio
We study how the non-Fermi-liquid nature of the overscreened multi-channel Kondo impurity model affects the response to a BCS pairing term that, in the absence of the impurity, opens a gap Δ. We find that the low-energy spectrum in the limit Δ → 0 actually does not correspond to the spectrum strictly at Δ = 0. In particular, in the two-channel Kondo model the Δ → 0 ground state is an orbitally degenerate spin-singlet, while it is an orbital singlet with a residual spin degeneracy at Δ = 0. In addition, there are fractionalized spin-1/2 sub-gap excitations whose energy in units of Δ tends towards a finite and universal value when Δ → 0; as if the universality of the anomalous power-law exponents that characterise the overscreened Kondo effect turned into universal energy ratios when the scale invariance is broken by Δ ≠ 0...
February 16, 2017: Physical Review. B
https://www.readbyqxmd.com/read/28501442/theoretical-fitting-characteristics-of-typical-soft-contact-lens-designs
#10
Anna Sulley, Kathrine Osborn Lorenz, James S Wolffsohn, Graeme Young
PUROSE: To calculate theoretical fitting success rates (SR) for a range of typical soft contact lens (SCL) designs using a mathematical model. METHOD: A spreadsheet mathematical model was used to calculate fitting SR for various SCL designs. Designs were evaluated using ocular topography data from 163 subjects. The model calculated SR based on acceptable edge strain (within range 0-6%) and horizontal diameter overlap (range 0.2-1.2mm). Where lenses had multiple base curves (BCs), eyes unsuccessful with the steeper BC were tested with the flatter BC and aggregate SR calculated...
May 10, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28501117/institutional-variation-in-surgical-care-for-early-stage-breast-cancer-at-community-hospitals
#11
Christopher M Dodgion, Stuart R Lipsitz, Marquita R Decker, Yue-Yung Hu, Sudha R Pavuluri Quamme, Anita Karcz, Leonard D'Avolio, Caprice C Greenberg
BACKGROUND: There is significant institutional variation in the surgical care of breast cancer, and this may reflect access to services and resultant physician practice patterns. In previous studies, specialty care has been associated with variation in the operative treatment of breast cancer but has not been evaluated in a community setting. This study investigates these issues in a cohort of 59 community hospitals in the United States. MATERIALS AND METHODS: Data on patients receiving an operation for breast cancer (2006-2009) in a large, geographically diverse cohort of hospitals were obtained...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28497258/clinical-pharmacokinetics-and-mass-balance-of-veliparib-in-combination-with-temozolomide-in-subjects-with-nonhematologic-malignancies
#12
Silpa Nuthalapati, Wijith Munasinghe, Vincent Giranda, Hao Xiong
BACKGROUND AND OBJECTIVES: Veliparib is an orally active potent poly(ADP-ribose) polymerase (PARP) inhibitor currently in phase III clinical trials in solid tumors. This phase I study evaluated the pharmacokinetics and mass balance of veliparib administered alone and in combination with temozolomide, and assessed any potential pharmacokinetic drug-drug interaction between veliparib and temozolomide. METHODS: This was an open-label, dose-escalation study of veliparib in combination with temozolomide in 42 subjects with nonhematologic malignancies...
May 11, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28496192/magnetic-field-tuning-of-an-excitonic-insulator-between-the-weak-and-strong-coupling-regimes-in-quantum-limit-graphite
#13
Z Zhu, R D McDonald, A Shekhter, B J Ramshaw, K A Modic, F F Balakirev, N Harrison
The excitonic insulator phase has long been predicted to form in proximity to a band gap opening in the underlying band structure. The character of the pairing is conjectured to crossover from weak (BCS-like) to strong coupling (BEC-like) as the underlying band structure is tuned from the metallic to the insulating side of the gap opening. Here we report the high-magnetic field phase diagram of graphite to exhibit just such a crossover. By way of comprehensive angle-resolved magnetoresistance measurements, we demonstrate that the underlying band gap opening occurs inside the magnetic field-induced phase, paving the way for a systematic study of the BCS-BEC-like crossover by means of conventional condensed matter probes...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494859/hiv-reprograms-human-airway-basal-stem-progenitor-cells-to-acquire-a-tissue-destructive-phenotype
#14
Nancy P Y Chung, Xuemei Ou, K M Faisal Khan, Jacqueline Salit, Robert J Kaner, Ronald G Crystal
While highly active anti-retroviral therapy has dramatically improved the survival of HIV-infected individuals, there is an increased risk for other co-morbidities, such as COPD, manifesting as emphysema. Given that emphysema originates around the airways and that human airway basal cells (BCs) are adult airway stem/progenitor cells, we hypothesized that HIV reprograms BCs to a distinct phenotype that contributes to the development of emphysema. Our data indicate that HIV binds to but does not replicate in BCs...
May 9, 2017: Cell Reports
https://www.readbyqxmd.com/read/28494154/adsorption-of-estrogen-contaminants-by-graphene-nanomaterials-under-nom-preloading-comparison-with-carbon-nanotube-biochar-and-activated-carbon
#15
Luhua Jiang, Yunguo Liu, Shaobo Liu, Guangming Zeng, Xin-Jiang Hu, Xi Hu, Zhi Guo, Xiao-Fei Tan, Lele Wang, Zhibin Wu
Adsorption of two estrogen contaminants (17β-estradiol and 17α-ethynyl estradiol) by graphene nanomaterials was investigated and compared with those of a multi-walled carbon nanotube (MWCNT), a single-walled carbon nanotube (SWCNT), two biochars, a powdered activated carbon (PAC), and a granular activate carbon (GAC) in ultrapure water and in the competition of natural organic matter (NOM). Graphene nanomaterials showed comparable or better adsorption ability than carbon nanotubes (CNTs), biochars (BCs) and activated carbon (ACs) under NOM preloading...
May 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28487146/evaluation-of-a-biphasic-in-vitro-dissolution-test-for-estimating-the-bioavailability-of-carbamazepine-polymorphic-forms
#16
Jia Deng, Sven Staufenbiel, Roland Bodmeier
The purpose of this study was to discriminate three crystal forms of carbamazepine (a BCS II drug) by in vitro dissolution testing and to correlate in vitro data with published in vivo data. A biphasic dissolution system (phosphate buffer pH6.8 and octanol) was used to evaluate the dissolution of the three polymorphic forms and to compare it with conventional single phase dissolution tests performed under sink and non-sink conditions. Similar dissolution profiles of three polymorphic forms were observed in the conventional dissolution test under sink conditions...
May 6, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28484731/bile-cast-syndrome-diagnosis-and-management-a-case-series
#17
Fahad F Mir, Sreenivasa S Jonnalagadda
Background and study aims Bile cast syndrome (BCS) is a complication of orthotopic liver transplantation (OLT). It occurs in 4 % to 18 % of OLT recipients and can present as cholangitis and graft damage or loss. Twenty-two percent of patients with BCS require repeat OLT. The diagnosis and management of BCS can be challenging. Our aim is to share our experience with BCS and to briefly review the diagnosis and management of the condition.
May 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28483602/chitosan-palmitic-acid-based-polymeric-micelles-as-promising-carrier-for-circumventing-pharmacokinetic-and-drug-delivery-concerns-of-tamoxifen
#18
Nagarani Thotakura, Mukesh Dadarwal, Rajendra Kumar, Bhupinder Singh, Gajanand Sharma, Pramod Kumar, Om Prakash Katare, Kaisar Raza
Being a BCS class II drug and a good substrate for microsomal enzymes, tamoxifen (TAM) offers a scope for research owing to poor aqueous solubility and compromised bioavailability. The present study designs a novel copolymer derived from palmitic acid and chitosan, and evaluate the derived TAM-loaded micelles for various delivery attributes. The nanometric micellar carriers not only substantially loaded the drug, but also controlled the rate of release of TAM. The designed nanocarrier significantly enhanced the cytotoxicity of TAM on MCF-7 cancer cells...
May 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28483422/biowaiver-monograph-for-immediate-release-solid-oral-dosage-forms-amoxicillin-trihydrate
#19
REVIEW
Dhanusha Thambavita, Priyadarshani Galappatthy, Uthpali Mannapperuma, R L Jayakody, Rodrigo Cristofoletti, Bertil Abrahamsson, D W Groot, Peter Langguth, Mehul Mehta, Alan Parr, James E Polli, Vinod P Shah, Jennifer Dressman
Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE/bioavailability (BA) studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875mg belong to BCS class I, while 1000 mg belongs to BCS class II and doses above 1000mg belong to BCS class IV...
May 5, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28480068/biliary-cancer-intrahepatic-cholangiocarcinoma-vs-extrahepatic-cholangiocarcinoma-vs-gallbladder-cancers-classification-and-therapeutic-implications
#20
REVIEW
Daniel H Ahn, Tanios Bekaii-Saab
Biliary cancers (BCs) are a diverse group of tumors that arise from the bile duct epithelium and are divided into cholangiocarcinomas of the intrahepatic and extrahepatic cholangiocarcinoma (EHCC) and cancer of the gallbladder. Despite improvements in treatment and diagnosis, BCs are often diagnosed at an advanced stage and associated with poor prognosis and limited treatment options. Recent discoveries have allowed us to have a better understanding of the genomic diversity in BC, and identify genes that are likely contributing to its pathogenesis, proliferation and treatment resistance...
April 2017: Journal of Gastrointestinal Oncology
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