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https://www.readbyqxmd.com/read/29150730/racial-differences-in-symptom-management-experiences-during-breast-cancer-treatment
#1
Cleo A Samuel, Jennifer Schaal, Linda Robertson, Jemeia Kollie, Stephanie Baker, Kristin Black, Olive Mbah, Crystal Dixon, Katrina Ellis, Eugenia Eng, Fatima Guerrab, Nora Jones, Amanda Kotey, Claire Morse, Jessica Taylor, Vickie Whitt, Samuel Cykert
PURPOSE: Racial disparities in cancer treatment-related symptom burden are well documented and linked to worse treatment outcomes. Yet, little is known about racial differences in patients' treatment-related symptom management experiences. Such understanding can help identify modifiable drivers of symptom burden inequities. As part of the Cancer Health Accountability for Managing Pain and Symptoms (CHAMPS) study, we examined racial differences in symptom management experiences among Black and White breast cancer survivors (BCS)...
November 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29150657/specific-heat-electrical-resistivity-and-electronic-band-structure-properties-of-noncentrosymmetric-th7fe3-superconductor
#2
V H Tran, M Sahakyan
Noncentrosymmetric superconductor Th7Fe3 has been investigated by means of specific heat, electrical resisitivity measurements and electronic properties calculations. Sudden drop in the resistivity at 2.05 ± 0.15 K and specific heat jump at 1.98 ± 0.02 K are observed, rendering the superconducting transition. A model of two BCS-type gaps appears to describe the zero-magnetic-field specific heat better than those based on the isotropic BCS theory or anisotropic functions. A positive curvature of the upper critical field H c2(T c) and nonlinear field dependence of the Sommerfeld coefficient at 0...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29147896/genetic-diagnosis-before-surgery-has-an-impact-on-surgical-decision-in-brca-mutation-carriers-with-breast-cancer
#3
Sungmin Park, Jeong Eon Lee, Jai Min Ryu, Issac Kim, Soo Youn Bae, Se Kyung Lee, Jonghan Yu, Seok Won Kim, Seok Jin Nam
BACKGROUND: The first aim of our study was to evaluate surgical decision-making by BRCA mutation carriers with breast cancer based on the timing of knowledge of their BRCA mutation status. The second aim was to evaluate breast cancer outcome following surgical treatment. METHODS: This was a retrospective study of 164 patients diagnosed with invasive breast cancer, tested for BRCA mutation, and treated with primary surgery between 2004 and 2015 at Samsung Medical Center in Seoul, Korea...
November 16, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29147887/a-preliminary-prediction-model-for-potentially-guiding-patient-choices-between-breast-conserving-surgery-and-mastectomy-in-early-breast-cancer-patients-a-dutch-experience
#4
Elvira Vos, Linetta Koppert, Winnifred van Lankeren, Cornelis Verhoef, Bas Groot Koerkamp, Myriam Hunink
PURPOSE: To guide early stage breast cancer patients to choose between breast conserving surgery (BCS) and mastectomy (MST) considering the predicted cosmetic result and quality of life (QoL). METHODS: A decision model was built to compare QoL after BCS and MST. Treatment could result in BCS with good cosmesis, BCS with poor cosmesis, MST only, and MST with breast reconstruction. QoL for these treatment outcomes were obtained from a previous study and the literature and translated into EuroQoL-5D derived utilities...
November 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29146885/mammary-phyllodes-tumour-a-15-year-multicentre-clinical-review
#5
Michael Co, Clement Chen, Julia Y Tsang, Gary Tse, Ava Kwong
AIMS: Phyllodes tumour (PT) is an uncommon fibroepithelial tumour of the breast. It has a spectrum of aggressiveness in biological behaviour with chance of local recurrence and, occasionally, metastasis. METHODS: A 15-year retrospective review from a multicentre database in Hong Kong was performed. RESULTS: Clinical and pathological records of 465 patients with 469 PTs between 1998 and 2014 were reviewed. Median age of occurrence was 44 years (range 12-86 years)...
November 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29146240/channelled-tablets-an-innovative-approach-to-accelerating-drug-release-from-3d-printed-tablets
#6
Muzna Sadia, Basel Arafat, Waqar Ahmed, Robert E Forbes, Mohamed A Alhnan
Conventional immediate release dosage forms involve compressing the powder with a disintegrating agent that enables rapid disintegration and dissolution upon oral ingestion. Among 3D printing technologies, the fused deposition modelling (FDM) 3D printing technique has considerable potential for patient-specific dosage form. However, the use of FDM 3D printing in tablet manufacturing requires large portion of polymer, which slows down drug release through erosion and diffusion mechanisms. In this study, we demonstrate for the first time the use of a novel design approach of caplets with perforating channels to accelerate drug release from 3D printed tablets...
November 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29143568/the-inter-rater-reliability-and-prognostic-value-of-coma-scales-in-nepali-children-with-acute-encephalitis-syndrome
#7
Stephen Ray, Ajit Rayamajhi, Laura J Bonnett, Tom Solomon, Rachel Kneen, Michael J Griffiths
Background Acute encephalitis syndrome (AES) is a common cause of coma in Nepali children. The Glasgow coma scale (GCS) is used to assess the level of coma in these patients and predict outcome. Alternative coma scales may have better inter-rater reliability and prognostic value in encephalitis in Nepali children, but this has not been studied. The Adelaide coma scale (ACS), Blantyre coma scale (BCS) and the Alert, Verbal, Pain, Unresponsive scale (AVPU) are alternatives to the GCS which can be used. Methods Children aged 1-14 years who presented to Kanti Children's Hospital, Kathmandu with AES between September 2010 and November 2011 were recruited...
November 16, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29137911/effect-of-supplementing-a-diet-with-monensin-sodium-and-saccharomyces-cerevisiae-on-reproductive-performance-of-ghezel-ewes
#8
Leila Ahmadzadeh, Ali Hosseinkhani, Hossein Daghighkia
Effect of supplementing a diet, in an attempt to enhance reproduction, with monensin sodium and Saccharomyces cerevisiae yeast on reproductive performance was investigated during the breeding season using 44 Ghezel ewes (body weight 56.97±7.47kg, age 2-5 years and body condition score (BCS) 2.5) which were allocated randomly in equal numbers to the four dietary treatments as follows: 1) Basal diet plus supplemental feed (450g/ewe/d) plus monensin sodium (30mg/ewe/d) (MS); 2) Basal diet plus supplemental feed (450 g/ewe/d) plusSaccharomyces cerevisiae yeast (4×10(9)CFU/ewe/d) (SC); 3) Basal diet plus supplemental feed (450g/ewe/d) (FG); 4) Basal diet (only grazing on pasture, Control; G)...
November 11, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29137746/ultrasonically-tailored-chemically-engineered-and-qbd-enabled-fabrication-of-agomelatine-nanoemulsion-optimization-characterization-ex-vivo-permeation-and-stability-study
#9
Shakeeb Ahmed, Azka Gull, Mahtab Alam, Mohd Aqil, Yasmin Sultana
The objective of present study was to develop a nanoemulsion formulation of agomelatine (BCS class II drug) for the solubility enhancement. Capmul MCM, Tween 80 and PEG-400 were selected as oil, surfactant and co-surfactant respectively. The high energy ultrasonication method was used for the preparation of nanoemulsion. Three-factor three-level central composite design was employed to get the best formulation. The independent variables selected for the optimization were % oil, %Smix and sonication time (second)...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137724/simplified-boundary-conditions-alter-cortical-trabecular-load-sharing-at-the-distal-radius-a-multiscale-finite-element-analysis
#10
Joshua E Johnson, Karen L Troy
High-resolution peripheral quantitative computed tomography (HR-pQCT) derived micro-finite element (FE) modeling is used to evaluate mechanical behavior at the distal radius microstructure. However, these analyses typically simulate non-physiologic simplified platen-compression boundary conditions on a small section of the distal radius. Cortical and trabecular regions contribute uniquely to distal radius mechanical behavior, and various factors affect these regions distinctly. Generalized strength predictions from standardized platen-compression analyses may not adequately capture region specific responses in bone...
November 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29134946/prediction-of-phonon-mediated-superconductivity-in-hole-doped-black-phosphorus
#11
Yanqing Feng, Hong Xi Sun, Junhui Sun, Zhibin Lu, Yong You
We study the conventional electron--phonon mediated superconducting properties of hole-doped Black Phosphorus by density functional calculations and get a quite large electron--phonon coupling (EPC) constant λ ~ 1.0 with transition temperature TC ~ 10 K, which is comparable to MgB2 when holes are doped into degenerate and nearly flat energy bands around the Fermi level. We predict that the softening of low-frequency B3g1 optical mode and its phonon displacement which breaks the lattice nonsymmorphic symmetry of gliding plane and lifts the band double degeneracy, lead to a large EPC...
November 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29134938/short-term-incubation-of-positive-blood-cultures-in-brain-heart-infusion-broth-accelerates-identification-of-bacteria-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#12
Ignacio Torres, Estela Gimenez, Tania Pascual, Felipe Bueno, Dixie Huntley, Mireia Martínez, David Navarro
PURPOSE: Fast identification of bacteria directly from positive blood cultures (BCs) by matrix-assisted laser desorption/ionization time-of-flight mass-spectrometry (MALDI-TOF MS) can be achieved either using the MALDI Sepsityper kit (protein extraction method) or after a short-term pre-cultivation step on solid medium. We developed a new method that involves short-term enrichment of positive BCs in brain-heart infusion broth (BHI) prior to MALDI-TOF MS analysis. METHODOLOGY: Eighty-four BCs flagged as positive were included in this study; these were processed in parallel either directly using the MALDI Sepsityper kit or following a short-term culture either in BHI or on Columbia blood agar with 5 % sheep blood (CBA)...
November 14, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29134937/-candidatus-phytoplasma-noviguineense-a-novel-taxon-associated-with-bogia-coconut-syndrome-and-banana-wilt-disease-on-the-island-of-new-guinea
#13
Akio Miyazaki, Toshiro Shigaki, Hiroaki Koinuma, Nozomu Iwabuchi, Gou Bue Rauka, Alfred Kembu, Josephine Saul, Kiyoto Watanabe, Takamichi Nijo, Kensaku Maejima, Yasuyuki Yamaji, Shigetou Namba
Bogia coconut syndrome (BCS) is one of the lethal yellowing (LY)-type diseases associated with phytoplasma presence that are seriously threatening coconut cultivation worldwide. It has recently emerged, and is rapidly spreading in northern parts of the island of New Guinea. BCS-associated phytoplasmas collected in different regions were compared in terms of 16S rRNA gene sequences, revealing high identity among them represented by strain BCS-Bo(R). Comparative analysis of the 16S rRNA gene sequences revealed that BCS-Bo(R) shared less than a 97...
November 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29134472/real-time-wireless-tumor-tracking-during-breast-conserving-surgery
#14
Natasja Janssen, Roeland Eppenga, Marie-Jeanne Vrancken Peeters, Frederieke van Duijnhoven, Hester Oldenburg, Jos van der Hage, Emiel Rutgers, Jan-Jakob Sonke, Koert Kuhlmann, Theo Ruers, Jasper Nijkamp
PURPOSE: To evaluate a novel surgical navigation system for breast conserving surgery (BCS), based on real-time tumor tracking using the Calypso[Formula: see text] 4D Localization System (Varian Medical Systems Inc., USA). Navigation-guided breast conserving surgery (Nav-BCS) was compared to conventional iodine seed-guided BCS ([Formula: see text]I-BCS). METHODS: Two breast phantom types were produced, containing spherical and complex tumors in which wireless transponders (Nav-BCS) or a iodine seed ([Formula: see text]I-BCS) were implanted...
November 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29133818/searching-for-prostate-cancer-by-fully-automated-magnetic-resonance-imaging-classification-deep-learning-versus-non-deep-learning
#15
Xinggang Wang, Wei Yang, Jeffrey Weinreb, Juan Han, Qiubai Li, Xiangchuang Kong, Yongluan Yan, Zan Ke, Bo Luo, Tao Liu, Liang Wang
Prostate cancer (PCa) is a major cause of death since ancient time documented in Egyptian Ptolemaic mummy imaging. PCa detection is critical to personalized medicine and varies considerably under an MRI scan. 172 patients with 2,602 morphologic images (axial 2D T2-weighted imaging) of the prostate were obtained. A deep learning with deep convolutional neural network (DCNN) and a non-deep learning with SIFT image feature and bag-of-word (BoW), a representative method for image recognition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate benign conditions (BCs) patients with prostatitis or prostate benign hyperplasia (BPH)...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132245/radial-vs-coccygeal-artery-doppler-blood-pressure-measurement-in-conscious-cats
#16
Florian K Zeugswetter, Alexander Tichy, Katharina Weber
Objectives The aims of the study were to compare the results of systolic blood pressure (SBP) measurements at the radial and coccygeal artery by Doppler ultrasonography and to assess the impact of gender, age, body weight, body condition score (BCS) and stress score on disagreements. Methods Eighty cats were included in this prospective, block randomised crossover trial. Blood pressure measurements were performed at home, during hospitalisation or in a local animal shelter by a single trained observer according to the latest ISFM consensus guidelines...
November 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29132037/flunixin-meglumine-improves-pregnancy-rate-in-embryo-recipient-beef-cows-with-an-excitable-temperament
#17
R K Kasimanickam, J B Hall, C T Estill, J P Kastelic, C Joseph, R L Abdel Aziz, D Nak
Objectives were to determine effects of: 1) handling temperament and administration of flunixin meglumine, an inhibitor of prostaglandin F2a (PGF2a) synthesis, given at the time of embryo transfer, on pregnancy rates in beef cattle embryo transfer recipients; 2) handling temperament and flunixin meglumine on peripheral concentrations of progesterone, cortisol, substance-P, prostaglandin F metabolites (PGFM, (13,14-dihydro-15-keto-PGF2a) and isoprostane 8-epi PGF2a; and 3) flunixin meglumine treatment on proportion of non-pregnant recipient cows returning to estrus within an expected interval...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29131903/slow-reading-in-glaucoma-is-it-due-to-the-shrinking-visual-span-in-central-vision
#18
MiYoung Kwon, Rong Liu, Bhavika N Patel, Christopher Girkin
Purpose: Glaucoma is a leading cause of blindness worldwide, characterized by progressive loss of retinal ganglion cells. Patients with bilateral glaucoma read slower than normal cohorts. Here we examined the factors that may underlie slow reading in glaucoma and determined the best predictor of reading speed in glaucoma. Methods: A total of 38 subjects participated in this study: 17 patients with primary open-angle glaucoma (mean age = 64.71 years) and 21 age-similar normal controls (58...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29128423/amorphous-solid-dispersions-and-nanocrystal-technologies-for-poorly-water-soluble-drug-delivery-an-update
#19
Scott V Jermain, Chris Brough, Robert O Williams
Poor water-solubility remains a typical property of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate, and bioavailability of these active ingredients belonging to biopharmaceutical classification system (BCS) II and IV classifications. Since the early 2000s, nanocrystal delivery and amorphous solid dispersions are more established techniques to overcome the limitations of poorly-water soluble drugs in FDA available products...
November 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29127538/the-shifting-paradigm-for-breast-cancer-surgery-in-patients-undergoing-neoadjuvant-chemotherapy
#20
Olga Kantor, Gaurav Ajmani, Chi-Hsiung Wang, Avisek Datta, Katharine Yao
INTRODUCTION: Surgical therapy for newly diagnosed breast cancer has changed over the past decade, but these trends have not been well documented in patients undergoing neoadjuvant therapy (NAC). METHODS: In a retrospective cohort study of the National Cancer Database (NCDB), we selected 285,514 women with clinical stage I-III breast cancer who underwent NAC or adjuvant therapy (AC) from 2006 to 2014. Breast-conserving surgery (BCS), unilateral mastectomy (UM), and bilateral mastectomy (BM) rates were compared between patients undergoing NAC and AC...
November 10, 2017: Annals of Surgical Oncology
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