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https://www.readbyqxmd.com/read/28937221/in-vivo-dissolution-and-systemic-absorption-of-immediate-release-ibuprofen-in-human-gastrointestinal-tract-under-fed-and-fasted-conditions
#1
Duxin Sun, Jason R Baker, Bo Wen, Ann Frances, Huixia Zhang, Alex Yu, Ting Zhao, Yasuhiro Tsume, Manjunath Pai, Barry Bleske, Xinyuan Zhang, R Lionberger, Allen Lee, Gordon Amidon, William L Hasler, Mark Koenigsknecht
PURPOSE: In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. METHODS: A multi-lumen GI catheter was orally inserted into the GI tract of healthy human subjects...
September 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28936092/multifocal-balo-s-concentric-sclerosis-in-children-report-of-a-case-and-review-of-literature
#2
Sanjeev Kumar Bhoi, Suprava Naik, Jayantee Kalita, U K Misra
Balo's concentric sclerosis (BCS) is a rare demyelinating lesion considered to be a variant of multiple sclerosis (MS). On magnetic resonance imaging (MRI) Balo's concentric sclerosis shows the typical concentric pattern. We report a case of 10 year old child with BCS who presented as post infectious acute disseminated encephalomyelitis (ADEM). He is asymptomatic and had no relapse after 6 years of follow-up.
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935407/insights-into-the-attenuated-sorption-of-organic-compounds-on-black-carbon-aged-in-soil
#3
Lei Luo, Jitao Lv, Zien Chen, Rixiang Huang, Shuzhen Zhang
Sorption of organic compounds on fresh black carbons (BCs) can be greatly attenuated in soil over time. We examined herein the changes in surface properties of maize straw-derived BCs (biochars) after aged in a black soil and their effects on the sorptive behaviors of naphthalene, phenanthrene and 1,3-dinitrobenzene. Dissolved fulvic and humic acids extracted from the soil were used to explore the role of dissolved organic carbon (DOC) in the aging of biochars. Chromatography analysis indicated that DOC molecules with relatively large molecular weight were preferentially adsorbed on the biochars during the aging processes...
September 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28935174/timp-3-mrna-expression-levels-positively-correlates-with-levels-of-mir-21-in-in-situ-bc-and-negatively-in-pr-positive-invasive-bc
#4
Nina Petrovic, Ahmad Sami, Jelena Martinovic, Marina Zaric, Irina Nakashidze, Silvana Lukic, Snezana Jovanovic-Cupic
BACKGROUND: Breast carcinomas (BC) belong to a heterogeneous group of malignant diseases. Correct categorization of BC based on molecular biomarkers has a very important role in deciding the proper course of therapy for each patient. It has been already shown that the decrease of TIMP metalloproteinase inhibitor 3 (TIMP-3) together with overexpression of microRNA-21 (miR-21) might be involved in the process of BC invasion. This is the first study that examined relationship among miR-21, TIMP-3 mRNA and TIPM-3 protein levels in BC groups formed according to invasiveness...
September 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28932502/ultrasound-guided-direct-intrahepatic-portosystemic-shunt-in-patients-with-budd-chiari-syndrome-short-and-long-term-results
#5
Adam Hatzidakis, Nikolaos Galanakis, Elias Kehagias, Dimitrios Samonakis, Mairi Koulentaki, Erminia Matrella, Dimitrios Tsetis
BACKGROUND AND AIMS: Budd-Chiari syndrome (BCS) is treated with anticoagulation therapy, transjugular intrahepatic portosystemic shunt (TIPS), angioplasty, and liver transplantation. TIPS is not always technically feasible, due to the complete hepatic venous thrombosis. Direct intrahepatic portosystemic shunt (DIPS) is an alternative method for decompression of portal hypertension. This is a retrospective, single-center study aiming to evaluate the outcome of ultrasound (US)-guided DIPS in patients with BCS...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28929821/effects-of-a-translational-community-based-multimodal-exercise-program-on-quality-of-life-and-the-influence-of-start-delay-on-physical-function-and-quality-of-life-in-breast-cancer-survivors-a-pilot-study
#6
Michael Paul Foley, Scott Michael Hasson, Eydie Kendall
The purpose of this investigation was 2-fold: (1) to investigate the effects of a translational 12-week community-based multimodal exercise program on quality of life (QoL) in breast cancer survivors (BCS) and (2) to examine the influence of a start delay on physical function and QoL in BCS. Fifty-two female BCS completed a 12-week program consisting of 90-minute supervised exercise sessions at a frequency of 2 supervised sessions per week. Exercise sessions consisted of three 30-minute components: (1) aerobic conditioning, (2) resistance exercise training, and (3) balance and flexibility training...
September 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28925888/a-self-nanoemulsifying-drug-delivery-system-for-poorly-water-soluble-tolbutamide-development-optimization-and-pharmacodynamic-studies
#7
Deepti Pandita, Neelam Kumari, Viney Lather
The current investigation involves the development of a thermodynamically stable and dilutable self-nanoemulsifying drug delivery system (SNEDDS) for tolbutamide, a poorly water soluble hypoglycemic drug, in order to achieve higher water solubility and enhanced dissolution rate which in turn improves its oral bioavailability. Pseudo-ternary phase diagrams suggested the suitability of oleic acid (lipid), Tween 20 (surfactant) and PEG 400 (co-surfactant) for developing the SNEEDS formulations. The optimal SNEDDS formulation having mean globule diameter, viscosity, polydispersity value of 58...
September 15, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28924730/effects-of-the-preparation-process-on-the-properties-of-amorphous-solid-dispersions
#8
Siyuan Huang, Robert O Williams
The use of amorphous solid dispersions to improve the bioavailability of active ingredients from the BCS II and IV classifications continues to gain interest in the pharmaceutical industry. Over the last decade, methods for generating amorphous solid dispersions have been well established in commercially available products and in the literature. However, the amorphous solid dispersions manufactured by different technologies differ in many aspects, primarily chemical stability, physical stability, and performance, both in vitro and in vivo...
September 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28923766/development-of-stability-enhanced-ternary-solid-dispersions-via-combinations-of-hpmcp-and-soluplus-%C3%A2-processed-by-hot-melt-extrusion
#9
Ahmad B Albadarin, Catherine B Potter, Mark Davis, Javed Iqbal, Sachin Korde, Sudhir Pagire, Anant Paradkar, Gavin Walker
The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus(®) polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was achieved using hot melt extrusion (HME) to convert the crystalline active pharmaceutical ingredient (API) into a more soluble amorphous form within the ternary systems. Itraconazole (ITZ), a Biopharmaceutics Classification System class II (BCS II) API, was utilized as the model drug...
September 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28923635/living-donor-liver-transplantation-for-budd-chiari-syndrome-case%C3%A2-series
#10
C Karaca, C Yilmaz, R Ferecov, Z Iakobadze, K Kilic, L Caglayan, S Aydogdu, M Kilic
BACKGROUND: Venous reconstruction in living-donor liver transplantation for Budd-Chiari syndrome (BCS) has challenges because the grafts from living donors lack vena cava, and hepatic venous anastomosis must be performed on an already-thrombosed and/or stenosed inferior vena cava. Several techniques are described to overcome this problem, and we represent our experience with 22 patients. METHODS: Medical recordings of 22 patients were retrospectively collected, and disease-specific data as well as recordings about surgical technique were analyzed...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28922103/budd-chiari-syndrome
#11
Tomáš Grus, Lukáš Lambert, Gabriela Grusová, Rohan Banerjee, Andrea Burgetová
Budd-Chiari syndrome (BCS) is a rare disease with an incidence of 0.1 to 10 per million inhabitants a year caused by impaired venous outflow from the liver mostly at the level of hepatic veins and inferior vena cava. Etiological factors include hypercoagulable conditions, myeloprolipherative diseases, anatomical variability of the inferior vena cava, and environmental conditions. Survival rates in treated patients range from 42 to 100% depending on the etiology and the presence of risk factors including parameters of Child-Pugh score, sodium and creatinine plasma levels, and the choice of treatment...
2017: Prague Medical Report
https://www.readbyqxmd.com/read/28919384/the-combination-of-gis-and-biphasic-to-better-predict-in-vivo-dissolution-of-bcs-class-iib-drugs-ketoconazole-and-raloxifene
#12
Yasuhiro Tsume, Naoto Igawa, Adam J Drelich, Gregory E Amidon, Gordon L Amidon
The formulation developments and the in vivo assessment of Biopharmaceutical Classification System (BCS) class II drugs are challenging due to their low solubility and high permeability in the human gastrointestinal (GI) tract. Since the GI environment influences the drug dissolution of BCS class II drugs, the human GI characteristics should be incorporated into the in vitro dissolution system to predict bioperformance of BCS class II drugs. An absorptive compartment may be important in dissolution apparatus for BCS class II drugs, especially for bases (BCS IIb) because of high permeability, precipitation and supersaturation...
September 14, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28919028/resumption-of-ovarian-function-the-metabolic-profile-and-body-condition-in-brahman-cows-bos-indicus-is-not-affected-by-the-combination-of-calf-separation-and-progestogen-treatment
#13
Ramiro Díaz, Carlos S Galina, Ivette Rubio, Manuel Corro, José Luis Pablos, Ana Rodríguez, Agustín Orihuela
To evaluate the effect of different calf separation procedures after a progestogen treatment on the resumption of ovarian function, body condition and metabolic profile, 59 multiparous Brahman cows grazing on a mixed grass pasture were studied. No supplementation was given at any time. Body condition score (BCS), fat thickness (FAT) and blood metabolites were measured fortnightly from the beginning of the last trimester of gestation until 96days postpartum. At 30days postpartum all animals received a progesterone (P4)-releasing device (CIDR) which was withdrawn 9days later when prostaglandin F2α was applied...
September 1, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28917445/margin-width-and-local-recurrence-after-breast-conserving-surgery-for-ductal-carcinoma-in-situ
#14
Gregory E Ekatah, Arran K Turnbull, Laura M Arthur, Jeremy Thomas, Christine Dodds, J Michael Dixon
INTRODUCTION: Ductal Carcinoma in situ (DCIS) represents 5% of symptomatic and 20-30% of screen detected cancers. Breast conserving surgery (BCS) ± radiotherapy is performed in over 70% of women with DCIS. What constitutes an adequate margin for BCS remains unclear. METHODS: A single institution follow up study has been conducted of 466 patients with pure DCIS treated by BCS between 2000 and 2010 of whom 292 received whole breast radiotherapy and 167 did not...
September 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28914464/expression-of-caveolin-1-in-the-interfollicular-but-not-the-follicle-associated-epithelial-cells-in-the-bursa-of-fabricius-of-chickens
#15
Ildikó Bódi, Krisztina Minkó, Orsolya Fölker, Zsófia Benyeda, Balázs Felföldi, Attila Magyar, Anna Kiss, Vilmos Palya, Imre Oláh
The surface epithelium of the bursa of Fabricius consists of interfollicular (IFE) and follicle-associated epithelium (FAE). The IFE comprises (i) cylindrical-shaped secretory cells (SC) and (ii) cuboidal basal cells (BCs). The FAE provides histological and two-way functional connections between the bursal lumen and medulla of the follicle. We used a carbon solution and anti-caveolin-1 (Cav-1) to study the endocytic activity of FAE. Carbon particles entered the intercellular space of FAE, but the carbon particles were not internalized by the FAE cells...
September 15, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28913761/radioactive-seed-localization-versus-wire-guided-localization-for-nonpalpable-breast-cancer-a-cost-and-operating-room-efficiency-analysis
#16
Yimeng Zhang, Jean Seely, Erin Cordeiro, Joshua Hefler, Kednapa Thavorn, Mukta Mahajan, Sue Domina, Jon Aro, Andrea Marie Ibrahim, Angel Arnaout, Denis Gravel, Carolyn Nessim
BACKGROUND: This study aimed to compare the cost and resource use between our first-year experience using breast-conserving surgery (BCS) with radioactive seed localization (RSL) and the previous-year standard practice of BCS with wire-guided localization (WGL) for patients with nonpalpable breast cancer at a large Canadian tertiary center. METHODS: For this retrospective cohort study, data for BCS cases with RSL was collected from 1 April 2015 to 31 March 2016 and for BCS cases with WGL from 1 April 2014 to 31 March 2015...
September 14, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28913697/developing-a-post-treatment-survivorship-care-plan-to-help-breast-cancer-survivors-understand-their-fertility
#17
Jessica R Gorman, Anne K Julian, Samantha A Roberts, Sally A D Romero, Jennifer L Ehren, Michael L Krychman, Sarah G Boles, Jun Mao, H Irene Su
PURPOSE: Reproductive-aged breast cancer survivors (BCS) who have completed initial cancer treatment frequently want to know about their future fertility potential. The purpose of this qualitative study was to assess if the fertility-related content presented in the survivorship care plan prototype met the informational needs of post-treatment BCS and to provide an opportunity for the target audience to review and react to the proposed content and design. METHODS: We conducted and analyzed transcripts from seven focus groups with BCS to evaluate their reactions to the survivorship care plan prototype...
September 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28911854/resumption-of-ovarian-function-the-metabolic-profile-and-body-condition-in-brahman-cows-bos-indicus-is-not-affected-by-the-combination-of-calf-separation-and-progestogen-treatment
#18
Ramiro Díaz, Carlos S Galina, Ivette Rubio, Manuel Corro, José Luis Pablos, Ana Rodríguez, Agustín Orihuela
To evaluate the effect of different calf separation procedures after a progestogen treatment on the resumption of ovarian function, body condition and metabolic profile, 59 multiparous Brahman cows grazing on a mixed grass pasture were studied. No supplementation was given at any time. Body condition score (BCS), fat thickness (FAT) and blood metabolites were measured fortnightly from the beginning of the last trimester of gestation until 96days postpartum. At 30days postpartum all animals received a progesterone (P4)-releasing device (CIDR) which was withdrawn 9days later when prostaglandin F2α was applied...
October 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28910357/the-quality-of-invasive-breast-cancer-care-for-low-reimbursement-rate-patients-a-retrospective-study
#19
Shaofei Su, Han Bao, Xinyu Wang, Zhiqiang Wang, Xi Li, Meiqi Zhang, Jiaying Wang, Hao Jiang, Wenji Wang, Siyang Qu, Meina Liu
Though evidence-based treatments have been recommended for breast cancer, underuse of the treatments was still observed. To certain extent, patients' access to care, which can be enhanced by increasing the coverage of health insurance, could account for the current underuse in recommended care. This study aimed to examine the association between different proportions of reimbursement and quality of recommended breast cancer care, as well as length of hospital stay. In this retrospective study, 3669 patients diagnosed with invasive breast cancer between 1 June, 2011 and 30 June, 2013 were recruited...
2017: PloS One
https://www.readbyqxmd.com/read/28903871/prevalence-and-risk-factors-for-transition-period-diseases-in-grazing-dairy-cows-in-brazil
#20
Rolnei R Daros, Maria J Hötzel, Jose A Bran, Stephen J LeBlanc, Marina A G von Keyserlingk
The aim of this cross-sectional study was to describe the incidence risk of dystocia, retained placenta (RP), pathological recumbence (down cow), the prevalence of metritis and subclinical ketosis (SCK), and the risk factors for SCK, metritis, and RP in grazing dairy herds in Southern Brazil. Fifty-three herds were visited 2-6 times from February to October of 2015. Body condition score (BCS), breed, days in milk (DIM), parity and disease status were recorded for each cow that was between 3 and 21 DIM at the time of the visits...
September 15, 2017: Preventive Veterinary Medicine
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