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https://www.readbyqxmd.com/read/29777844/angioplasty-for-budd-chiari-syndrome-in-a-child-with-26-year-follow-up
#1
Xixiang Gao, Zhu Tong, Lianrui Guo, Jianxin Li, Jian Zhang, Yongquan Gu
Budd-Chiari syndrome (BCS) is a rare but life-threatening disease. If not treated promptly, it is almost always lethal of progressive liver failure, severe nutritional depletion, and renal failure at the late stage. We report the successful treatment of a 5-year-old boy with BCS due to a stenosis of the IVC with a 26-year follow-up. We performed percutaneous transluminal angioplasty (PTA), which resulted in a great improvement of BCS, and the disappearance of ascites. Restenosis occurred at 25 years after the initial angioplasty, for which balloon angioplasty was repeatedly performed...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772881/geographic-access-to-radiation-therapy-facilities-and-disparities-of-early-stage-breast-cancer-treatment
#2
Yan Lin, Michael C Wimberly, Patricia Da Rosa, Joseph Hoover, William F Athas
Few studies of breast cancer treatment have focused on the Northern Plains of the United States, an area with a high mastectomy rate. This study examined the association between geographic access to radiation therapy facilities and receipt of breast cancer treatments among early-stage breast cancer patients in South Dakota. Based on 4,209 early-stage breast cancer patients diagnosed between 2001 and 2012 in South Dakota, the study measured geographic proximity to radiation therapy facilities using the shortest travel time for patients to the closest radiation therapy facility...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29771426/the-relationship-between-the-levels-and-function-of-endothelial-progenitor-cells-and-factor-v-leiden-and-protein-c-deficiency-in-patients-with-primary-budd-chiari-syndrome
#3
Z-Y Guan, C-W Yu, T Song, Y Gao
OBJECTIVE: Budd-Chiari syndrome (BCS) is a life-threatening hepatic disease characterized by hepatic venous obstruction at the level of hepatic vein, hepatic venules, or inferior vena cava. No evidence reported the relationship between the endothelial progenitor cells and the deficiency of factor V Leiden and protein C in patients with primary Budd-Chiari syndrome. PATIENTS AND METHODS: We recruited participants between June 2014 and July 2015. For primary BCS group, 28 patients were collected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29768251/balo-s-concentric-sclerosis-an-update-and-comprehensive-literature-review
#4
Ali Amini Harandi, Akram Esfandani, Hossein Pakdaman, Mehdi Abbasi, Mohammad Ali Sahraian
Balo's concentric sclerosis (BCS) is considered a variant of multiple sclerosis characterized by concentric lamella of alternating demyelinated and partially myelinated tissues. It is a rare and a relatively acute condition. Attacks may proceed rapidly over weeks or months, typically without remission, like Marburg's variant, resulting in death or severe disability. However, the majority of cases have a more benign, self-limiting course with spontaneous remission. Magnetic resonance imaging is a primary imaging modality in the diagnosis of BCS...
May 16, 2018: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/29763688/combined-effects-of-the-drug-distribution-and-mucus-diffusion-properties-of-self-microemulsifying-drug-delivery-systems-on-the-oral-absorption-of-fenofibrate
#5
Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Yusuke Tanaka, Kunikazu Moribe
We present the absorption improvement mechanism of fenofibrate (FFB), a Biopharmaceutics Classification System (BCS) class II drug, from self-microemulsifying drug delivery systems (SMEDDS), centered on improving the diffusion of FFB through the unstirred water layer (UWL). Four SMEDDS formulations containing LabrafacTM lipophile WL 1349 (WL1349) or Labrafil® M 1944CS (M1944) oils and NIKKOL HCO-40 (HCO40) or NIKKOL HCO-60 (HCO60) surfactants were prepared. Every SMEDDS formulation formed microemulsion droplets of approximately 30 nm...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29762040/orally-bioavailable-and-effective-buparvaquone-lipid-based-nanomedicines-for-visceral-leishmaniasis
#6
Lindsay A Smith, Dolores Remedios Serrano, Marion Mauger, Francisco Bolás-Fernández, Maria Auxiliadora Dea-Ayuela, Aikaterini Lalatsa
Nano-enabled lipid based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need for further toxicological studies, while they remain affordable and amenable to scale-up. Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug)...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29760076/high-temperature-superconductivity-using-a-model-of-hydrogen-bonds
#7
Daniel Kaplan, Yoseph Imry
Recently, there has been much interest in high-temperature superconductors and more recently in hydrogen-based superconductors. This work offers a simple model that explains the behavior of the superconducting gap based on naive BCS (Bardeen-Cooper-Schrieffer) theory and reproduces most effects seen in experiments, including the isotope effect and [Formula: see text] enhancement as a function of pressure. We show that this is due to a combination of the factors appearing in the gap equation: the matrix element between the proton states and the level splitting of the proton...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759914/symptom-cluster-of-emotional-distress-fatigue-and-cognitive-difficulties-among-young-and-older-breast-cancer-survivors-the-mediating-role-of-subjective-stress
#8
Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta Fried
OBJECTIVES: To examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster. MATERIALS AND METHODS: Participants were 170 BCS, stages I-III, 1-12 months post-chemotherapy, filled-out the Fatigue, Emotional Control, Meaning-focused Coping, Emotional Distress and the Cognitive Difficulties Questionnaires...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29759139/identifying-cytokine-predictors-of-cognitive-functioning-in-breast-cancer-survivors-up-to-10-years-post-chemotherapy-using-machine-learning
#9
Ashley M Henneghan, Oxana Palesh, Michelle Harrison, Shelli R Kesler
INTRODUCTION: The purpose of this study is to explore 13 cytokine predictors of chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCS) 6 months to 10 years after chemotherapy completion using a multivariate, non-parametric approach. METHODS: Cross sectional data collection included completion of a survey, cognitive testing, and non-fasting blood from 66 participants. Data were analyzed using random forest regression to identify the most significant predictors for each of the cognitive test scores...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29758532/evaluation-of-the-nova-vet-meter-for-sheep-side-monitoring-of-%C3%AE-hydroxybutyric-acid-bhba-and-description-of-ewe-bhba-during-late-gestation-in-three-flocks-from-the-northeastern-u-s
#10
Amanda K Jones, Rachael E Gately, Tasia D Kellogg, Steven A Zinn, Kristen E Govoni, Sarah A Reed
Prevention of metabolic diseases in small ruminants may improve production efficiency and profitability, yet ewes carrying multiples or who are in poor body condition are at increased susceptibility to develop ketosis. This study evaluated the hand-held Nova Vet Meter to accurately detect β-hydroxybutyric acid (BHBA) concentrations in ewes and determined the percentage of ewes at moderate (0.8 to 1.5 mmol/L BHBA) and greatest (≥1.6 mmol/L BHBA) risk to develop ketosis during late gestation. To validate the Nova Vet Meter, BHBA concentrations of 104 paired blood samples were measured using the Nova Vet Meter and gold-standard laboratory analysis...
May 7, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29756819/evidence-from-quantum-monte-carlo-simulations-of-large-gap-superfluidity-and-bcs-bec-crossover-in-double-electron-hole-layers
#11
Pablo López Ríos, Andrea Perali, Richard J Needs, David Neilson
We report quantum Monte Carlo evidence of the existence of large gap superfluidity in electron-hole double layers over wide density ranges. The superfluid parameters evolve from normal state to BEC with decreasing density, with the BCS state restricted to a tiny range of densities due to the strong screening of Coulomb interactions, which causes the gap to rapidly become large near the onset of superfluidity. The superfluid properties exhibit similarities to ultracold fermions and iron-based superconductors, suggesting an underlying universal behavior of BCS-BEC crossovers in pairing systems...
April 27, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29755191/26s-proteasome-and-insulin-like-growth-factor-1-in-serum-of-dogs-suffering-from-malignant-tumors
#12
Ingrid Gerke, Franz-Josef Kaup, Stephan Neumann
Studies in humans have shown that the ubiquitin-proteasome pathway and the insulin-like growth factor axis are involved in carcinogenesis, thus, components of these systems might be useful as prognostic markers and constitute potential therapeutic targets. In veterinary medicine, only a few studies exist on this topic. Here, serum concentrations of 26S proteasome (26SP) and insulin-like growth factor-1 (IGF-1) were measured by canine enzyme-linked immunosorbent assay (ELISA) in 43 dogs suffering from malignant tumors and 21 clinically normal dogs (control group)...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29751280/evaluation-of-serum-insulin-like-growth-factor-1-and-26s-proteasome-concentrations-in-healthy-dogs-and-dogs-with-chronic-diseases-depending-on-body-condition-score
#13
Ingrid Gerke, Franz-Josef Kaup, Stephan Neumann
In patients suffering from chronic diseases, the objective assessment of metabolic states could be of interest for disease prognosis and therapeutic options. Therefore, the aim of this study was to assess insulin-like growth factor-1 (IGF-1) and 26S proteasome (26SP) in healthy dogs and dogs suffering from chronic diseases depending on their body condition score (BCS) and to examine their potential for objective assessment of anabolic and catabolic states. Serum concentrations of IGF-1, an anabolic hormone, and 26SP, a multiprotein complex which is part of the ubiquitin-proteasome pathway, by which the majority of endogenous proteins including the muscle proteins are degraded, were measured in 21 healthy dogs and 20 dogs with chronic diseases by canine ELISA...
April 26, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29747486/omitting-adjuvant-radiotherapy-for-hormone-receptor%C3%A2-positive-early-stage-breast-cancer-in-old-age-a-propensity-score-matched-seer-analysis
#14
Yi-Jun Kim, Kyung Hwan Shin, Kyubo Kim
Purpose: The purpose of this study was to investigate the non-inferiority of omitting radiotherapy (RT) after breast-conserving surgery (BCS) for hormone receptor (HR)‒positive T1N0 breast cancer in elderly women. Materials and Methods: From 2004 to 2014, HR-positive T1N0 breast cancer patients aged 50 years or older and receiving BCS were retrieved from the Surveillance, Epidemiology, and End. Results: 18 database. After propensity score matching between the no-RT and RT groups, univariate and multivariate analyses were performed...
May 10, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29744672/efficacy-and-safety-of-neoadjuvant-treatment-with-bevacizumab-liposomal-doxorubicin-cyclophosphamide-and-paclitaxel-combination-in-locally-regionally-advanced-her2-negative-grade-iii-at-premenopausal-status-breast-cancer-a-phase-ii-study
#15
Ekaterini C Tampaki, Athanasios Tampakis, Constantinos E Alifieris, Dimitrios Krikelis, Anastasia Pazaiti, Michalis Kontos, Dimitrios T Trafalis
BACKGROUND: In the era of personalized therapy, targeted treatment in specific patient populations is mandated. OBJECTIVE: We evaluated the efficacy and safety of neoadjuvant treatment on locally advanced breast cancer (LABC) with a monoclonal agent against vascular endothelial growth factor (VEGF), bevacizumab plus chemotherapy combination of liposomal doxorubicin, cyclophosphamide and paclitaxel (PLAC-B). METHODS: Patients enrolled were at premenopausal status and characterized by human epidermal growth factor receptor 2 (HER2)-negative, hormone-receptor positive (estrogen receptor/progesterone receptor-positive [ER/PR+]) or triple-negative (TNBC), LABC (T > 3 cm), with high-grade ductal carcinoma...
May 9, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29743653/long-term-outcome-of-recoverable-stents-for-budd-chiari-syndrome-complicated-with-inferior-vena-cava-thrombosis
#16
Yonghua Bi, Hongmei Chen, Penxu Ding, Jianzhuang Ren, Xinwei Han
This study aimed to present long-term results of a 12-year patient follow-up of recoverable stents for BCS complicated by inferior vena cava (IVC) thrombosis. Forty consecutive patients with BCS complicated by IVC thrombosis were treated with recoverable stents. The median duration of symptoms was 24 months. Recoverable stents was placed after predilation of the obstructed IVC, and then agitation thrombolysis or catheter-directed thrombolysis of IVC was performed. The recoverable stents was removed eventually after thrombus disappeared...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740914/effects-of-physical-activity-on-psychological-well-being-outcomes-in-breast-cancer-survivors-from-pre-diagnosis-to-post-treatment-survivorship
#17
Susan Aguiñaga, Diane K Ehlers, Josh Cosman, Joan Severson, Arthur F Kramer, Edward McAuley
OBJECTIVE: The purpose of this study was to examine the effects of physical activity from pre-diagnosis to post-treatment survivorship on the psychological well-being (PWB) outcomes of fatigue, depression, anxiety, and quality of life (QoL) in breast cancer survivors (BCS). METHODS: Participants (N=387) completed a questionnaire battery using an iPad-based platform. Measures included self-reported PA (before diagnosis and currently), and perceptions of fatigue, depression, anxiety, and QoL...
May 8, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29740104/setup-errors-and-effectiveness-of-optical-laser-3d-surface-imaging-system-sentinel-in-postoperative-radiotherapy-of-breast-cancer
#18
Xiaobo Wei, Mengjiao Liu, Yun Ding, Qilin Li, Changhai Cheng, Xian Zong, Wenming Yin, Jie Chen, Wendong Gu
Breast-conserving surgery (BCS) plus postoperative radiotherapy has become the standard treatment for early-stage breast cancer. The aim of this study was to compare the setup accuracy of optical surface imaging by the Sentinel system with cone-beam computerized tomography (CBCT) imaging currently used in our clinic for patients received BCS. Two optical surface scans were acquired before and immediately after couch movement correction. The correlation between the setup errors as determined by the initial optical surface scan and CBCT was analyzed...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738787/experimental-challenges-regarding-the-in-vitro-investigation-of-the-nanoparticle-biocorona-in-disease-states
#19
Sherleen Xue-Fu Adamson, Zhoumeng Lin, Ran Chen, Lisa Kobos, Jonathan Shannahan
Toxicological evaluation of nanoparticles (NPs) requires the utilization of in vitro techniques due to their number and diverse properties. Cell culture systems are often lacking in their ability to perform comparative toxicity assessment due to dosimetry issues and capacity to simulate in vivo environments. Upon encountering a physiological environment, NPs become coated with biomolecules forming a biocorona (BC), influencing function, biodistribution, and toxicity. Disease-induced alterations in the biological milieu can alter BC formation...
May 5, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29737554/canine-recommended-breed-weight-ranges-are-not-a-good-predictor-of-an-ideal-body-condition-score
#20
E G Smith, K Davis, L Sulsh, S C Harvey, K E Fowler
Breed-specific ideal bodyweight range information is widely used by dog owners and breeders as a guideline to ensure animals are within a healthy weight range. Body Condition Scoring, a method used by veterinarians to assess an animal's overall shape with regard to weight is considered to be an excellent method to determine an animal's overall body condition; these values, however, do not always correspond to published weight ranges. Here, the weight, neuter status, age and a nine-point Body Condition Score of a population of 140 purebred dogs were recorded and subsequently analysed to determine whether bodyweight was an effective predictor for Body Condition Scores...
May 8, 2018: Journal of Animal Physiology and Animal Nutrition
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