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https://www.readbyqxmd.com/read/29150217/idiopathic-macular-telangiectasia-type-2-prevalence-and-a-morphometric-and-phenotypic-study
#1
R M Bayón-Porras, I Pascual-Camps, C Plaza-Laguardia, R Gallego-Pinazo
OBJECTIVE: Type 2 idiopathic macular telangiectasia (MacTel2) is a rare retinal disease that has still not been well-defined. The aim of the present manuscript is to describe the clinical features by multimodal retinal imaging, to present the functional characteristics, and to estimate the prevalence of the disease. METHODS: A retrospective study was conducted on the 12 eyes of 6 patients with MacTel2. Fundus colour photographs, fundus autofluorescence, fluorescein angiography, optical coherence tomography (OCT), and OCT-angiography were performed and subsequently analysed...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29109897/optic-coherence-angiography-findings-in-type-2-macular-telangiectasia
#2
Hilal Nalcı, Figen Şermet, Sibel Demirel, Emin Özmert
Objectives: To evaluate the vascular changes of idiopathic macular telangiectasia type 2 (MacTel 2) patients with optical coherence tomography angiography (OCTA) and correlate these changes with the findings of spectral domain optical coherence tomography (SD-OCT). Materials and Methods: Simultaneous SD-OCT and OCTA images of 10 eyes of 6 patients who were diagnosed as MacTel 2 in Ankara University Faculty of Medicine, Department of Ophthalmology were obtained and graded according to the OCTA grading system for MacTel 2...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29095354/characteristics-of-pigmented-lesions-in-type-2-idiopathic-macular-telangiectasia
#3
Irene Leung, Ferenc B Sallo, Roberto Bonelli, Traci E Clemons, Daniel Pauleikhoff, Emily Y Chew, Alan C Bird, Tunde Peto
PURPOSE: Pigment in the midretina is a characteristic sign in Type 2 idiopathic macular telangiectasia (MacTel) and is considered to characterize the late stage of the disease. Our aim was to investigate its incidence, and relationship with risk factors for MacTel, including outer retinal vascularization and subretinal neovascular proliferation (SRNV). METHODS: Pigment extent was measured in fundus autofluorescence images of 150 eyes of 75 MacTel probands, using the Region Finder tool of Heidelberg Eye Explorer...
October 31, 2017: Retina
https://www.readbyqxmd.com/read/29045321/fundus-wide-subretinal-and-pigment-epithelial-abnormalities-in-macular-telangiectasia-type-2
#4
Michael B Powner, Sasha M Woods, Meidong Zhu, Mark C Gillies, Paul S Bernstein, Gregory S Hageman, Grant M Comer, Catherine Egan, Marcus Fruttiger
PURPOSE: Macular telangiectasia Type 2 (MacTel) causes glial and photoreceptor cell death in a small, oval patch in the central retina. Beyond this oval area, no disease manifestations have been described so far. Here, we describe a novel pathological aspect of MacTel in the retinal pigment epithelium (RPE) that is not restricted to the clinically affected area but covers the entire retina. METHODS: We have studied postmortem eyes from four patients with MacTel by immunohistochemistry and electron microscopy...
October 17, 2017: Retina
https://www.readbyqxmd.com/read/29016451/concurrent-idiopathic-macular-telangiectasia-type-2-and-central-serous-chorioretinopathy
#5
Alexandre Matet, Suzanne Yzer, Emily Y Chew, Alejandra Daruich, Francine Behar-Cohen, Richard F Spaide
PURPOSE: To describe cases presenting with features of idiopathic macular telangiectasia (MacTel) Type 2 and central serous chorioretinopathy (CSC). METHODS: Databases from four tertiary retina centers were searched for cases copresenting CSC and MacTel Type 2. RESULTS: Five cases were identified (4 men, 1 woman; mean age: 67.2 years). Four patients were referred for chronic or nonresolving CSC, and the diagnosis of MacTel Type 2 was made based on multimodal imaging findings...
October 9, 2017: Retina
https://www.readbyqxmd.com/read/28973315/correlation-between-macular-integrity-assessment-and-optical-coherence-tomography-imaging-of-ellipsoid-zone-in-macular-telangiectasia-type-2
#6
RANDOMIZED CONTROLLED TRIAL
Dibyendu Mukherjee, Eleonora M Lad, Ryan R Vann, Stephanie J Jaffe, Traci E Clemons, Martin Friedlander, Emily Y Chew, Glenn J Jaffe, Sina Farsiu
Purpose: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). Methods: Macular SD-OCT volumes and microperimetry maps were obtained during the international, multicenter, randomized phase 2 trial of ciliary neurotrophic factor for type 2 MacTel on two visits within 5 days of one another. Software was developed to register SD-OCT to MAIA scanning laser ophthalmoscopy images and to overlay EZ defect areas on the microperimetry maps generated from microperimetry sensitivity values at specific points and from interpolated sensitivity values...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28905826/risk-factors-in-patients-with-macular-telangiectasia-2a-in-an-asian-population-a-case-control-study
#7
Anna Elias, Mahesh Gopalakrishnan, Giridhar Anantharaman
PURPOSE: The aim of this study was to evaluate risk factors in patients with macular telangiectasia (MacTel) 2A in an Asian population. This was a hospital-based case-control study. METHODS: We reviewed the case records of patients in our hospital, diagnosed as MacTel 2A over a 3-year period from April 2011 to March 2014. Controls were selected from patients seen in the hospital at the same time for visual defects after matching for age and sex. A multivariate logistic regression model was constructed using the variables that showed a statistically significant association (P < 0...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28903123/potential-effects-of-hormone-therapy-in-type-2-idiopathic-macular-telangiectasia
#8
Ute E K Wolf-Schnurrbusch, Irene Leung, Ferenc B Sallo, Traci E Clemons, Emily Y Chew, Alan C Bird, Tunde Peto
PURPOSE: To investigate the influence of hormone therapy with tamoxifen or estrogens on morphological changes in macular telangiectasia (MacTel) type 2 patients as revealed clinically in multiple imaging modalities. METHODS: Patients with a history of tamoxifen or estrogen use were selected from the cohort of the MacTel Study. A race-, age- and best-corrected visual acuity-matched group of MacTel participants not under hormone therapy served as the comparison group...
September 13, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28834952/macular-telangiectasia-type-2-quantitative-analysis-of-a-novel-phenotype-and-implications-for-the-pathobiology-of-the-disease
#9
Mali Okada, Catherine A Egan, Tjebo F C Heeren, Adnan Tufail, Marcus Fruttiger, Peter M Maloca
PURPOSE: To investigate retinal microcystoid spaces in macular telangiectasia type 2 with spectral domain optical coherence tomography. METHODS: Retrospective review of 135 patients enrolled in the MacTel Natural History Observation and Registry Study at Moorfields Eye Hospital, United Kingdom. One hundred seventy-two eyes from 86 patients who had a comparable scan protocol of at least 30 μm interval were included for analysis. Retinal microcystoid spaces were identified and segmented and metrics analyzed...
August 22, 2017: Retina
https://www.readbyqxmd.com/read/28803666/-inefficacy-of-aflibercept-in-the-treatment-of-idiopathic-macular-telangiectasia-type-2%C3%A2-without-neovascularization
#10
J Bénichou, V Soler, D Denis, F Matonti
Idiopathic macular telangectasia type 2 is a rare disease consisting primarily of bilateral macular capillary telangiectasia, alterations of the ellipsoid zone and intraretinal cysts that may appear as cystoid macular edema in the absence of neovascularization. Our goal was to study the efficacy of aflibercept in the treatment of these cysts. Thus, we performed a series of three intravitreal injections of aflibercept in the right eye of a woman with a typical presentation of macular telangectasia type 2 complicated by cystoid macular edema without neovascularization...
September 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28728169/correlations-between-macular-skin-and-serum-carotenoids
#11
Christopher D Conrady, James P Bell, Brian M Besch, Aruna Gorusupudi, Kelliann Farnsworth, Igor Ermakov, Mohsen Sharifzadeh, Maia Ermakova, Werner Gellermann, Paul S Bernstein
Purpose: Ocular and systemic measurement and imaging of the macular carotenoids lutein and zeaxanthin have been employed extensively as potential biomarkers of AMD risk. In this study, we systematically compare dual wavelength retinal autofluorescence imaging (AFI) of macular pigment with skin resonance Raman spectroscopy (RRS) and serum carotenoid levels in a clinic-based population. Methods: Eighty-eight patients were recruited from retina and general ophthalmology practices from a tertiary referral center and excluded only if they did not have all three modalities tested, had a diagnosis of macular telangiectasia (MacTel) or Stargardt disease, or had poor AFI image quality...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727884/oct-angiography-and-ellipsoid-zone-mapping-of-macular-telangiectasia-type-2-from-the-avatar-study
#12
Anne P Runkle, Peter K Kaiser, Sunil K Srivastava, Andrew P Schachat, Jamie L Reese, Justis P Ehlers
Purpose: To evaluate alterations on optical coherence tomography angiography (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes with macular telangiectasia type 2 (MacTel type 2). Methods: The Observational Assessment of Visualizing and Analyzing Vessels With Optical Coherence Tomography Angiography in Retinal Diseases study is an institutional review board-approved prospective, observational study investigating OCT-A in macular disease...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28654457/effect-of-dark-adaptation-and-bleaching-on-blue-light-reflectance-imaging-in-macular-telangiectasia-type-2
#13
Mali Okada, Tjebo F C Heeren, Catherine A Egan, Vincent Rocco, Roberto Bonelli, Marcus Fruttiger
PURPOSE: In patients with macular telangiectasia Type 2, blue light reflectance imaging reveals an oval, parafoveal area in the macula that has increased reflectance compared with its surrounding. Here, we examine how dark adaptation and photobleaching can affect the blue light reflectance imaging pattern. METHODS: Prospective study of patients with macular telangiectasia enrolled in the MacTel Natural History Observation Study. After dark adaptation, a sequence of images was obtained with a confocal scanning laser ophthalmoscope at 488 nm...
June 26, 2017: Retina
https://www.readbyqxmd.com/read/28644304/abnormal-retinal-reflectivity-to-short-wavelength-light-in-type-2-idiopathic-macular-telangiectasia
#14
Ferenc B Sallo, Irene Leung, Meike Zeimer, Traci E Clemons, Adam M Dubis, Marcus Fruttiger, Daniel Pauleikhoff, Emily Y Chew, Catherine Egan, Tunde Peto, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was to investigate the relationship of this sign with other signs of macular telangiectasia Type 2 in multiple imaging modalities. METHODS: Participants were selected from the MacTel Type 2 study, based on a confirmed diagnosis and the availability of images...
June 21, 2017: Retina
https://www.readbyqxmd.com/read/28609329/scotoma-characteristics-in-macular-telangiectasia-type-2-mactel-project-report-no-7-the-mactel-research-group
#15
Stela Vujosevic, Tjebo F C Heeren, Daniela Florea, Irene Leung, Daniel Pauleikhoff, Ferenc Sallo, Alan Bird, Tunde Peto
PURPOSE: To characterize scotomas in macular telangiectasia Type 2 (MacTel). METHODS: Five of the 27 centers performed microperimetry as part of the MacTel Natural History Observation Study. Data were analyzed in the Moorfields Eye Hospital Reading Centre. The number of stimuli under a threshold of 12, 10, 8, and <0 dB were counted (thresholding) and compared with one another. RESULTS: A total of 565 examinations were gradable, received from 632 eyes of 322 participants (age 61...
May 22, 2017: Retina
https://www.readbyqxmd.com/read/28541963/correlation-of-structural-and-functional-outcome-measures-in-a-phase-one-trial-of-ciliary-neurotrophic-factor-in-type-2-idiopathic-macular-telangiectasia
#16
Ferenc B Sallo, Irene Leung, Traci E Clemons, Tunde Peto, Emily Y Chew, Daniel Pauleikhoff, Alan C Bird
PURPOSE: Macular telangiectasia Type 2 is a bilateral, progressive, potentially blinding retinal disease characterized by both vascular and neurodegenerative signs. Both the area of the break in the ellipsoid zone seen in "en face" optical coherence tomographic (OCT) images and microperimetric focal retinal sensitivity loss have been proposed as potential measures of progression in macular telangiectasia. The authors aimed to assess the characteristics and interrelationship of these structural and functional disease markers from the data collected in a phase one clinical trial of ciliary neurotrophic factor in macular telangiectasia...
May 23, 2017: Retina
https://www.readbyqxmd.com/read/28541959/longitudinal-correlation-of-ellipsoid-zone-loss-and-functional-loss-in-macular-telangiectasia-type-2
#17
Tjebo F C Heeren, Diána Kitka, Daniela Florea, Traci E Clemons, Emily Y Chew, Alan C Bird, Daniel Pauleikhoff, Peter Charbel Issa, Frank G Holz, Tunde Peto
PURPOSE: To compare ellipsoid zone (EZ) loss and functional loss in macular telangiectasia (MacTel) type 2 longitudinally. METHODS: Prospective natural history study. Ellipsoid zone loss was measured in en-face images created from spectral domain optical coherence tomography. Functional loss was assessed by best-corrected visual acuity and microperimetry, counting the number of test points with impaired function. RESULTS: A total of 56 eyes of 31 participants were followed for 4...
May 24, 2017: Retina
https://www.readbyqxmd.com/read/28505012/correlation-of-clinical-and-structural-progression-with-visual-acuity-loss-in-macular-telangiectasia-type-2-mactel-project-report-no-6-the-mactel-research-group
#18
Tunde Peto, Tjebo F C Heeren, Traci E Clemons, Ferenc B Sallo, Irene Leung, Emily Y Chew, Alan C Bird
PURPOSE: To evaluate progression of macular telangiectasia Type 2 lesions and their correlation with visual acuity. METHODS: An international multicenter prospective study with annual examinations including best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography, and optical coherence tomography images graded centrally. Mixed models were used to estimate progression rates, and a generalized linear model to compute the relative risk of BCVA loss, loss of ellipsoid zone (EZ) reflectivity, development of pigment plaques, or neovascularization...
May 11, 2017: Retina
https://www.readbyqxmd.com/read/28250457/genome-wide-analyses-identify-common-variants-associated-with-macular-telangiectasia-type-2
#19
Thomas S Scerri, Anna Quaglieri, Carolyn Cai, Jana Zernant, Nori Matsunami, Lisa Baird, Lea Scheppke, Roberto Bonelli, Lawrence A Yannuzzi, Martin Friedlander, Catherine A Egan, Marcus Fruttiger, Mark Leppert, Rando Allikmets, Melanie Bahlo
Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS) with 476 cases and 1,733 controls of European ancestry. Genome-wide significant associations (P < 5 × 10(-8)) were identified at three independent loci (rs73171800 at 5q14.3, P = 7.74 × 10(-17); rs715 at 2q34, P = 9.97 × 10(-14); rs477992 at 1p12, P = 2.60 × 10(-12)) and then replicated (P < 0...
April 2017: Nature Genetics
https://www.readbyqxmd.com/read/28195982/identification-of-increased-blue-light-reflectivity-in-macular-telangiectasia-type-2-using-scanning-laser-ophthalmoscopy-versus-red-free-fundus-photography
#20
Talha Soorma, Tjebo Heeren, Daniela Florea, Irene Leung, Tunde Peto
PURPOSE: To compare two modalities used for detection of the characteristic parafoveal hyperreflective area seen in macular telangiectasia Type 2. METHODS: Scanning laser ophthalmoscope blue light reflectance was compared with red-free fundus photography imaging. Images were obtained as part of the international Natural History Study of Macular Telangiectasia (MacTel Study). RESULTS: The hyperreflective area can more frequently be seen with scanning laser ophthalmoscope blue light reflectance than with red-free imaging...
February 10, 2017: Retinal Cases & Brief Reports
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