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Lisa Toto, Luca Di Antonio, Rodolfo Mastropasqua, Peter A Mattei, Paolo Carpineto, Enrico Borrelli, Marco Rispoli, Bruno Lumbroso, Leonardo Mastropasqua
PURPOSE: To report morphologic features of idiopathic macular telangiectasia (MacTel) type 2 by means of optical coherence tomography angiography (OCTA) and to compare these findings to fundus fluorescein angiography (FFA), fundus autofluorescence (FAF), confocal blue reflectance (CBR), and spectral-domain OCT (SD-OCT). In addition, foveal vessel density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness (PFRT) were compared between MacTel 2 patients and normal aged-matched controls...
July 1, 2016: Investigative Ophthalmology & Visual Science
Jaclyn L Kovach, Harald Hess, Philip J Rosenfeld
A 60-year-old man diagnosed with macular telangiectasia type 1 (MacTel 1) was treated for 3 years with monthly aflibercept (Eylea; Regeneron, Tarrytown, NY) and serially imaged with spectral-domain optical coherence tomography. When administered monthly, aflibercept appeared to have a beneficial effect on macular edema secondary to MacTel 1. Visual acuity preservation despite minimal chronic macular edema could be attributed to the lack of significant photoreceptor disruption. [Ophthalmic Surg Lasers Imaging Retina...
June 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Anna C S Tan, Chandrakumar Balaratnasingam, Lawrence A Yannuzzi
BACKGROUND AND OBJECTIVE: To assess the outcomes of patients with macular telangiectasia type 2 (MacTel 2) in response to lutein (L), meso-zeaxanthin (M), and zeaxanthin (Z) supplements (LMZ3). PATIENTS AND METHODS: Thirteen patients diagnosed with MacTel 2 were started on lutein 10 mg, meso-zeaxanthin 10 mg, and zeaxanthin 2 mg and were followed-up for a mean period of 15.7 months ± 4.85 months. RESULTS: Visual acuity improved in three patients (13%), and there was a reduction in the percentage of patients who had worsening vision (25% to 4%; P < ...
June 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Okan Toygar, Matthew G Guess, David S Youssef, Daniel M Miller
PURPOSE: To assess the long-term visual acuity results for intravitreal bevacizumab therapy in the treatment of subretinal neovascular membrane (SRNVM) secondary to idiopathic macular telangiectasia (Mactel) Type 2. METHODS: This retrospective review of a consecutive, interventional case series includes patients with SRNVM secondary to Mactel Type 2 who were seen at Cincinnati Eye Institute from February 2006 to December 2014. Best-corrected visual acuity, fluorescein angiography, and optical coherence tomography measurements were performed...
June 2, 2016: Retina
Daniel Lavinsky, Jenny Wang, Philip Huie, Roopa Dalal, Seung Jun Lee, Dae Yeong Lee, Daniel Palanker
PURPOSE: Retinal photocoagulation and nondamaging laser therapy are used for treatment of macular disorders, without understanding of the response mechanism and with no rationale for dosimetry. To establish a proper titration algorithm, we measured the range of tissue response and damage threshold. We then evaluated safety and efficacy of nondamaging retinal therapy (NRT) based on this algorithm for chronic central serous chorioretinopathy (CSCR) and macular telangiectasia (MacTel). METHODS: Retinal response to laser treatment below damage threshold was assessed in pigmented rabbits by expression of the heat shock protein HSP70 and glial fibrillary acidic protein (GFAP)...
May 1, 2016: Investigative Ophthalmology & Visual Science
Irini P Chatziralli, Poonam K Sharma, Sobha Sivaprasad
PURPOSE: The purpose of this systematic review was to stratify the literature on the therapeutic approaches for macular telangiectasia (Mactel type 1 and 2) to provide evidenced-based practical guidelines for the optimal standard care of these conditions. METHODS: A comprehensive search of PubMed was performed using a specific search algorithm. All articles retrieved were carefully screened and their references were manually reviewed for additional relevant data...
April 14, 2016: Seminars in Ophthalmology
Lavanya Chidambara, Santosh G K Gadde, Naresh Kumar Yadav, Chaitra Jayadev, Devanshi Bhanushali, Abhishek M Appaji, Mukunda Akkali, Aruj Khurana, Rohit Shetty
BACKGROUND: Macular telangiectasia type 2 (MacTel 2) is a bilateral idiopathic, rare neurodegenerative disease with alterations in the macular capillary network leading to vision loss and is the most common of three subtypes. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality which helps understand the complex pathological changes, and images the blood vessels across different layers based on their flow characteristics. METHODS: A cross-sectional study was conducted on 56 eyes of Asian Indian eyes of 28 consecutive patients with MacTel 2 studied during a 3-month period in a tertiary eye care hospital of South India...
January 28, 2016: British Journal of Ophthalmology
Qinqin Zhang, Ruikang K Wang, Chieh-Li Chen, Andrew D Legarreta, Mary K Durbin, Lin An, Utkarsh Sharma, Paul F Stetson, John E Legarreta, Luiz Roisman, Giovanni Gregori, Philip J Rosenfeld
BACKGROUND/PURPOSE: To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). METHODS: Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1,050 nm swept-source OCT prototype system. The OMAG algorithm generated en face flow images from three retinal layers, and the region bounded by the outer retina and Bruch membrane, the choriocapillaris, and the remaining choroidal vasculature...
November 2015: Retina
Julie Jacob, Valérie Krivosic, Michel Paques, Ramin Tadayoni, Alain Gaudric
PURPOSE: To determine whether cone photoreceptors are impaired early in macular telangiectasia type 2 (MacTel 2) progression. METHODS: Eight patients with MacTel 2 lacking intraretinal cavitation underwent multimodal retinal imaging including adaptive optics. Cone packing metrics were determined in 5 sampling windows at different eccentricities from the fovea. Results were compared with a previously established normative database. RESULTS: In MacTel 2 eyes, cone density was significantly lower than normal at all eccentricities (P < 0...
March 2016: Retina
D Pauleikhoff, B Heimes, G Spital, M Gutfleisch, M Ziegler, B Book, M-L Farecki, A P Lommatzsch
Recent developements in OCT technology using high speed acquisition and calculation of consecutive scans (SSADA = split spectrum amplitude decorrelation algorithm) have resulted in the possibility to demonstrate retinal and choroidal vessels in the macula. This new technology of "OCT angiography" thus allows the non-invasive and rapid (within seconds) reconstruction of the three-dimensional structure of the retinal and choroidal vascularisation. There are still limitations caused by movement artefacts, superposition of superficial retinal vessels at the RPE level or insufficient three-dimensional imaging, but the first experience with this new method and especially the correlations with the current standard diagnostic procedure fluorescein angiography shows that especially for vascular changes which are predominantly in one retinal layer (e...
September 2015: Klinische Monatsblätter Für Augenheilkunde
Tjebo F C Heeren, Traci Clemons, Hendrik P N Scholl, Alan C Bird, Frank G Holz, Peter Charbel Issa
PURPOSE: To investigate progressive vision loss in patients with macular telangiectasia (MacTel) type 2 and to compare the ability to detect functional decline between microperimetry and visual acuity testing. METHODS: Change of cumulative defect size (number of test points with absolute scotoma) on microperimetry testing and change in distance best-corrected visual acuity (BCVA) were evaluated in a prospective longitudinal observational study. RESULTS: The mean review period was 55...
June 2015: Investigative Ophthalmology & Visual Science
Sung Hyun Kim, Jaeryung Oh, Soh-Eun Ahn, Choul Yong Park, Jong-Hyun Oh
PURPOSE: To investigate the clinical and demographic features of idiopathic macular telangiectasia (MacTel) in Korean patients since the introduction of spectral domain optical coherence tomography (SD-OCT). METHODS: We reviewed medical records of patients who were diagnosed with MacTel from 2009 to 2013. All patients underwent fluorescein angiography and SD-OCT and were classified as type 1 or type 2 according to the classification system proposed by Yannuzzi. RESULTS: Over a period of 5 years, 4 (18...
June 2015: Korean Journal of Ophthalmology: KJO
Min Zhao, Charlotte Andrieu-Soler, Laura Kowalczuk, María Paz Cortés, Marianne Berdugo, Marilyn Dernigoghossian, Francisco Halili, Jean-Claude Jeanny, Brigitte Goldenberg, Michèle Savoldelli, Mohamed El Sanharawi, Marie-Christine Naud, Wilfred van Ijcken, Rosanna Pescini-Gobert, Danielle Martinet, Alejandro Maass, Jan Wijnholds, Patricia Crisanti, Carlo Rivolta, Francine Behar-Cohen
We have identified and characterized a spontaneous Brown Norway from Janvier rat strain (BN-J) presenting a progressive retinal degeneration associated with early retinal telangiectasia, neuronal alterations, and loss of retinal Müller glial cells resembling human macular telangiectasia type 2 (MacTel 2), which is a retinal disease of unknown cause. Genetic analyses showed that the BN-J phenotype results from an autosomal recessive indel novel mutation in the Crb1 gene, causing dislocalization of the protein from the retinal Müller glia (RMG)/photoreceptor cell junction...
April 15, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Jay Chhablani, Harsha B Rao, Viquar Unnisa Begum, Ganesh Babu Jonnadulla, Ashwin Goud, Giulio Barteselli
PURPOSE: To analyze the changes in retinal ganglion cells (RGCs) in eyes with nonproliferative macular telangiectasia type 2A (MacTel), by evaluating macular ganglion cell-inner plexiform layer (GCIPL) thickness and macular retinal nerve fiber layer (RNFL) thickness in comparison to age-matched healthy volunteers. METHODS: We performed a retrospective analysis of 99 eyes (53 subjects) with nonproliferative MacTel who underwent fundus fluorescein angiography and spectral domain optical coherence tomography using Cirrus HD-OCT...
February 2015: Investigative Ophthalmology & Visual Science
Qinyun Wang, William S Tuten, Brandon J Lujan, Jennifer Holland, Paul S Bernstein, Steven D Schwartz, Jacque L Duncan, Austin Roorda
PURPOSE: To evaluate visual function and disease progression in the retinal structural abnormalities of three patients from two unrelated families with macular telangiectasia (MacTel) type 2. METHODS: Adaptive optics scanning laser ophthalmoscopy (AOSLO) and AOSLO microperimetry (AOMP) were used to evaluate the structure and function of macular cones in three eyes with MacTel type 2. Cone spacing was estimated using histogram analysis of intercone distances, and registered spectral-domain optical coherence tomography (SD-OCT) scans were used to evaluate retinal anatomy...
February 2015: Investigative Ophthalmology & Visual Science
Emily Y Chew, Traci E Clemons, Tunde Peto, Ferenc B Sallo, Avner Ingerman, Weng Tao, Lawrence Singerman, Steven D Schwartz, Neal S Peachey, Alan C Bird
PURPOSE: To evaluate the safety and tolerability of intraocular delivery of ciliary neurotrophic factor (CNTF) using an encapsulated cell implant for the treatment of macular telangiectasia type 2. DESIGN: An open-label safety trial conducted in 2 centers enrolling 7 participants with macular telangiectasia type 2. METHODS: The participant's more severely affected eye (worse baseline visual acuity) received the high-dose implant of CNTF. Patients were followed for a period of 36 months...
April 2015: American Journal of Ophthalmology
Eric J Sigler, John C Randolph, Jorge I Calzada, Steve Charles
PURPOSE: To report the anatomical and visual outcomes in a series of patients with type 2 idiopathic macular telangiectasia (mactel) and cystic foveal changes treated with pars plana vitrectomy and internal limiting membrane removal. METHODS: Five eyes of 3 patients with mactel were treated with 25-gauge sutureless transconjunctival pars plana vitrectomy and internal limiting membrane peeling. Complete clinical examination, including serial spectral-domain optical coherence tomography, was performed preoperatively and postoperatively...
2013: Retinal Cases & Brief Reports
Richard F Spaide, James M Klancnik, Michael J Cooney
IMPORTANCE: Macular telangiectasia type 2 (MacTel 2) is a rare disease in which abnormalities of the retinal vasculature play a key role. The vascular abnormalities are typically evaluated using fluorescein angiography, a modality with known defects in imaging the deeper layers of the retinal vasculature. Angiography based on optical coherence tomography can image vessels based on flow characteristics without dye injection and may provide improved information concerning the pathophysiology of MacTel 2...
January 2015: JAMA Ophthalmology
Heleen Nicolai, Mieke Wirix, Leigh Spielberg, Anita Leys
We report macular telangiectasia type 2 (MacTel) in a 34-year-old man, the youngest patient so far published with MacTel type 2. The patient presented with metamorphopsia and impaired reading ability. Diagnosis was based on bilateral abnormal macular autofluorescence, perifoveal telangiectasia with fluorescein angiographic hyperfluorescence without cystoid oedema, a small foveal avascular zone, asymmetric configuration of the foveal pit, disruptions in the inner segment/outer segment layer and hyper-reflective haze and spots in the outer nuclear layer...
2014: BMJ Case Reports
P Charbel Issa, D Pauleikhoff, F G Holz
No abstract text is available yet for this article.
September 2014: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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