Kumari Binita Chandra, Vikrant Kumar, Swati Ranjan, Abhinav Saini, Anil Kumar Tomar, Jai Bhagwan Sharma, Sandeep R Mathur, Savita Yadav
The asymptomatic nature, high rate of disease recurrence, and resistance to platinum-based chemotherapy highlight the need to identify and characterize novel target molecules for ovarian cancer. Fibroblast growth factor 8 (FGF8) aids in the development and metastasis of ovarian cancer; however, its definite role is not clear. We employed ELISA and IHC to examine the expression of FGF8 in the saliva and tissue samples of epithelial ovarian cancer (EOC) patients and controls. Furthermore, various cell assays were conducted to determine how FGF8 silencing influences ovarian cancer cell survival, adhesion, migration, and invasion to learn more about the functions of FGF8...
September 18, 2023: International Journal of Molecular Sciences