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https://www.readbyqxmd.com/read/27932240/surgery-versus-5-imiquimod-for-nodular%C3%A2-and-superficial-basal-cell-carcinoma-5-year-results-of-the-sins%C3%A2-randomized-controlled-trial
#1
Hywel C Williams, Fiona Bath-Hextall, Mara Ozolins, Sarah J Armstrong, Graham B Colver, William Perkins, Paul S J Miller
We previously reported modest clinical 3-year benefit for topical imiquimod compared with surgery for superficial or nodular basal cell carcinoma at low-risk sites in our noninferiority randomized controlled SINS trial. Here we report 5-year data. Participants were randomized to imiquimod 5% cream once daily (superficial basal cell carcinoma, 6 weeks; nodular basal cell carcinoma, 12 weeks) or excisional surgery (4-mm margin). The primary outcome was clinical absence of initial failure or signs of recurrence at the 3-year dermatology review...
November 23, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27932218/bisphenol-a-bpa-in-the-serum-of-pet-dogs-following-short-term-consumption-of-canned-dog-food-and-potential-health-consequences-of-exposure-to-bpa
#2
Zoe L Koestel, Robert C Backus, Kaoru Tsuruta, William G Spollen, Sarah A Johnson, Angela B Javurek, Mark R Ellersieck, Charles E Wiedmeyer, Kurunthachalam Kannan, Jingchuan Xue, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld
Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. Moreover, this chemical can bioaccumulate in various terrestrial and aquatic sources; thereby ensuring continual exposure of animals and humans. For most species, including humans, diet is considered the primary route of exposure. However, there has been little investigation whether commercial-brands of dog foods contain BPA and potential health ramifications of BPA-dietary exposure in dogs. We sought to determine BPA content within dog food, whether short-term consumption of these diets increases serum concentrations of BPA, and potential health consequences, as assessed by potential hematological, serum chemistry, cortisol, DNA methylation, and gut microbiome changes, in dogs associated with short-term dietary exposure to BPA...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27932216/arsenic-contamination-of-drinking-water-in-ireland-a-spatial-analysis-of-occurrence-and-potential-risk
#3
Ellen R McGrory, Colin Brown, Norma Bargary, Natalya Hunter Williams, Anthony Mannix, Chaosheng Zhang, Tiernan Henry, Eve Daly, Sarah Nicholas, Barbara M Petrunic, Monica Lee, Liam Morrison
The presence of arsenic in groundwater has become a global concern due to the health risks from drinking water with elevated concentrations. The Water Framework Directive (WFD) of the European Union calls for drinking water risk assessment for member states. The present study amalgamates readily available national and sub-national scale datasets on arsenic in groundwater in the Republic of Ireland. However, due to the presence of high levels of left censoring (i.e. arsenic values below an analytical detection limit) and changes in detection limits over time, the application of conventional statistical methods would inhibit the generation of meaningful results...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27927711/paget-schroetter-syndrome-imaged-in-multiple-modalities-and-successfully-treated-with-pharmacomechanical-thrombectomy
#4
James William Ryan, Alexandra Murphy, Sarah Wrafter, Vinny Ramiah
No abstract text is available yet for this article.
December 7, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27924031/ubiquitylation-dependent-regulation-of-neil1-by-mule-and-trim26-is-required-for-the-cellular-dna-damage-response
#5
Matthew J Edmonds, Rachel J Carter, Catherine M Nickson, Sarah C Williams, Jason L Parsons
Endonuclease VIII-like protein 1 (NEIL1) is a DNA glycosylase involved in initiating the base excision repair pathway, the major cellular mechanism for repairing DNA base damage. Here, we have purified the major E3 ubiquitin ligases from human cells responsible for regulation of NEIL1 by ubiquitylation. Interestingly, we have identified two enzymes that catalyse NEIL1 polyubiquitylation, Mcl-1 ubiquitin ligase E3 (Mule) and tripartite motif 26 (TRIM26). We demonstrate that these enzymes are capable of polyubiquitylating NEIL1 in vitro, and that both catalyse ubiquitylation of NEIL1 within the same C-terminal lysine residues...
October 18, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923089/correlations-between-ratings-on-the-resident-annual-evaluation-summary-and-the-internal-medicine-milestones-and-association-with-abim-certification-examination-scores-among-us-internal-medicine-residents-2013-2014
#6
Karen E Hauer, Jonathan Vandergrift, Brian Hess, Rebecca S Lipner, Eric S Holmboe, Sarah Hood, William Iobst, Stanley J Hamstra, Furman S McDonald
Importance: US internal medicine residency programs are now required to rate residents using milestones. Evidence of validity of milestone ratings is needed. Objective: To compare ratings of internal medicine residents using the pre-2015 resident annual evaluation summary (RAES), a nondevelopmental rating scale, with developmental milestone ratings. Design, Setting, and Participants: Cross-sectional study of US internal medicine residency programs in the 2013-2014 academic year, including 21 284 internal medicine residents (7048 postgraduate-year 1 [PGY-1], 7233 PGY-2, and 7003 PGY-3)...
December 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27919261/caf%C3%A3-a-multicomponent-audit-and-feedback-intervention-to-improve-implementation-of-healthy-food-policy-in-primary-school-canteens-a-randomised-controlled-trial
#7
Sze Lin Yoong, Nicole Nathan, Luke Wolfenden, John Wiggers, Kathryn Reilly, Christopher Oldmeadow, Rebecca Wyse, Rachel Sutherland, Tessa Delaney, Peter Butler, Lisa Janssen, Sarah Preece, Christopher M Williams
BACKGROUND: The implementation of nutrition policies in schools has been recommended as a strategy to improve child dietary intake. Internationally, research suggests that the majority of schools do not implement these policies. In New South Wales (NSW), Australia, the NSW Healthy School Canteen Policy requires that school canteens prohibit the sale of 'red' foods (i.e. foods that are typically nutrient poor and high in energy, such as confectionary and deep-fried foods) and 'banned'drinks (i...
December 5, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27919027/phosphorylation-of-janus-kinase-1-jak1-by-amp-activated-protein-kinase-ampk-links-energy-sensing-to-anti-inflammatory-signaling
#8
Claire Rutherford, Claire Speirs, Jamie J L Williams, Marie-Ann Ewart, Sarah J Mancini, Simon A Hawley, Christian Delles, Benoit Viollet, Ana P Costa-Pereira, George S Baillie, Ian P Salt, Timothy M Palmer
Adenosine 5'-monophosphate-activated protein kinase (AMPK) is a pivotal regulator of metabolism at cellular and organismal levels. AMPK also suppresses inflammation. We found that pharmacological activation of AMPK rapidly inhibited the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in various cells. In vitro kinase assays revealed that AMPK directly phosphorylated two residues (Ser(515) and Ser(518)) within the Src homology 2 domain of JAK1. Activation of AMPK enhanced the interaction between JAK1 and 14-3-3 proteins in cultured vascular endothelial cells and fibroblasts, an effect that required the presence of Ser(515) and Ser(518) and was abolished in cells lacking AMPK catalytic subunits...
November 8, 2016: Science Signaling
https://www.readbyqxmd.com/read/27916269/optimizing-the-treatment-of-ovarian-cancer-neoadjuvant-chemotherapy-and-interval-debulking-versus-primary-debulking-surgery-for-epithelial-ovarian-cancers-likely-to-have-suboptimal-resection
#9
Sarah E Gill, Michaela E McGree, Amy L Weaver, William A Cliby, Carrie L Langstraat
OBJECTIVE: To: a) identify prognostic factors in patients with epithelial ovarian cancer treated with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS), and b) compare post-surgical survival between patients treated with NACT/IDS for presumed unresectable disease and stage IIIC/IV patients who underwent suboptimal primary debulking surgery (PDS). METHODS: This was a retrospective study of consecutive stage IIIC or IV patients undergoing IDS after NACT at Mayo Clinic from January 2007 to December 2013...
December 1, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27915378/mother-infant-interactions-and-regional-brain-volumes-in-infancy-an-mri-study
#10
Vaheshta Sethna, Inês Pote, Siying Wang, Maria Gudbrandsen, Anna Blasi, Caroline McCusker, Eileen Daly, Emily Perry, Kerrie P H Adams, Maria Kuklisova-Murgasova, Paula Busuulwa, Sarah Lloyd-Fox, Lynne Murray, Mark H Johnson, Steven C R Williams, Declan G M Murphy, Michael C Craig, Grainne M McAlonan
It is generally agreed that the human brain is responsive to environmental influences, and that the male brain may be particularly sensitive to early adversity. However, this is largely based on retrospective studies of older children and adolescents exposed to extreme environments in childhood. Less is understood about how normative variations in parent-child interactions are associated with the development of the infant brain in typical settings. To address this, we used magnetic resonance imaging to investigate the relationship between observational measures of mother-infant interactions and regional brain volumes in a community sample of 3- to 6-month-old infants (N = 39)...
December 3, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27913673/structural-insights-into-functional-amyloid-inhibition-in-gram-ve-bacteria
#11
REVIEW
William Hawthorne, Sarah Rouse, Lee Sewell, Stephen J Matthews
Amyloids are proteinaceous aggregates known for their role in debilitating degenerative diseases involving protein dysfunction. Many forms of functional amyloid are also produced in nature and often these systems require careful control of their assembly to avoid the potentially toxic effects. The best-characterised functional amyloid system is the bacterial curli system. Three natural inhibitors of bacterial curli amyloid have been identified and recently characterised structurally. Here, we compare common structural features of CsgC, CsgE and CsgH and discuss the potential implications for general inhibition of amyloid...
December 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27913200/pharyngeal-swallowing-mechanics-secondary-to-hemispheric-stroke
#12
Nelson H May, Jessica M Pisegna, Sarah Marchina, Susan E Langmore, Sandeep Kumar, William G Pearson
BACKGROUND: Computational analysis of swallowing mechanics (CASM) is a method that utilizes multivariate shape change analysis to uncover covariant elements of pharyngeal swallowing mechanics associated with impairment using videofluoroscopic swallowing studies. The goals of this preliminary study were to (1) characterize swallowing mechanics underlying stroke-related dysphagia, (2) decipher the impact of left and right hemispheric strokes on pharyngeal swallowing mechanics, and (3) determine pharyngeal swallowing mechanics associated with penetration-aspiration status...
November 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27912931/consensus-statement-surgical-stabilization-of-rib-fractures-rib-fracture-colloquium-clinical-practice-guidelines
#13
Fredric M Pieracci, Sarah Majercik, Francis Ali-Osman, Darwin Ang, Andrew Doben, John G Edwards, Bruce French, Mario Gasparri, Silvana Marasco, Christian Minshall, Babak Sarani, William Tisol, Don H VanBoerum, Thomas W White
No abstract text is available yet for this article.
November 27, 2016: Injury
https://www.readbyqxmd.com/read/27911566/pedometer-step-count-targets-during-pulmonary-rehabilitation-in-copd-a-randomized-controlled-trial
#14
Claire M Nolan, Matthew Maddocks, Jane L Canavan, Sarah E Jones, Veronica Delogu, Djeya Kaliaraju, Winston Banya, Samantha S C Kon, Michael I Polkey, William D-C Man
RATIONALE: Increasing physical activity is a key therapeutic aim in COPD. Pulmonary rehabilitation (PR) improves exercise capacity, but there is conflicting evidence regarding its ability to improve physical activity levels. OBJECTIVE: To determine whether using pedometers as an adjunct to PR can enhance time spent in at least moderate intensity physical activity (time ≥ 3METs) in people with COPD. METHODS: In this single-blinded randomized controlled trial, participants were assigned 1:1 to receive control (PR comprising 8 weeks, two supervised sessions/week) or intervention (PR plus pedometer-directed step targets, reviewed weekly for 8 weeks)...
December 2, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27907243/an-optimized-centrifugal-method-for-separation-of-semen-from-superabsorbent-polymers-for-forensic-analysis
#15
Lucy R Camarena, Bailey K Glasscock, Demi Daniels, Nicolle Ackley, Marybeth Sciarretta, Sarah J Seashols-Williams
Connection of a perpetrator to a sexual assault is best performed through the confirmed presence of semen, thereby proving sexual contact. Evidentiary items can include sanitary napkins or diapers containing superabsorbent polymers (SAPs), complicating spermatozoa visualization and DNA analysis. In this report, we evaluated the impact of SAPS on the current forensic DNA workflow, developing an efficient centrifugal protocol for separating spermatozoa from SAP material. The optimized filtration method was compared to common practices of excising the top layer only, resulting in significantly higher sperm yields when a core sample of the substrate was taken...
December 1, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27903732/parkin-deficiency-reduces-hippocampal-glutamatergic-neurotransmission-by-impairing-ampa-receptor-endocytosis
#16
Giuseppe P Cortese, Mei Zhu, Damian Williams, Sarah Heath, Clarissa L Waites
: Mutations in the gene encoding Parkin, an E3 ubiquitin ligase, lead to juvenile-onset Parkinson's disease by inducing the selective death of midbrain dopaminergic neurons. Accumulating evidence indicates that Parkin also has an important role in excitatory glutamatergic neurotransmission, although its precise mechanism of action remains unclear. Here, we investigate Parkin's role at glutamatergic synapses of rat hippocampal neurons. We find that Parkin-deficient neurons exhibit significantly reduced AMPA receptor (AMPAR)-mediated currents and cell-surface expression, and that these phenotypes result from decreased postsynaptic expression of the adaptor protein Homer1, which is necessary for coupling AMPAR endocytic zones with the postsynaptic density...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27900673/expansion-of-the-phenotypic-spectrum-of-propionic-acidemia-with-isolated-elevated-propionylcarnitine
#17
Gerarda Cappuccio, Paldeep S Atwal, Taraka R Donti, Kiki Ugarte, Nadia Merchant, William J Craigen, V Reid Sutton, Sarah H Elsea
We report three patients with elevations of propionylcarnitine (C3), one without elevations of 2-methylcitrate and 3-hydroxypropionate in urine organic acid analysis, and the other two showing only mild elevations, all of whom were subsequently confirmed to have propionic acidemia by molecular analysis of PCCA and PCCB genes. To date, they have had a mild clinical course. These cases illustrate the importance of considering high C3 as the only biochemical abnormality in a diagnosis of propionic acidemia. Since mild C3 elevations may be overlooked and considered non-diagnostic in isolation, we advise considering a diagnosis of propionic acidemia even in the absence of significant elevations 2-methylcitrate or 3-hydroxypropionate in urine organic acid analysis...
November 30, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27900425/erratum-to-aryl-hydrocarbon-receptor-signaling-modifies-toll-like-receptor-regulated-responses-in-human-dendritic-cells
#18
Sarah Kado, W L William Chang, Aimy Nguyen Chi, Monika Wolny, David M Shepherd, Christoph F A Vogel
No abstract text is available yet for this article.
November 29, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27899575/ensembl-2017
#19
Bronwen L Aken, Premanand Achuthan, Wasiu Akanni, M Ridwan Amode, Friederike Bernsdorff, Jyothish Bhai, Konstantinos Billis, Denise Carvalho-Silva, Carla Cummins, Peter Clapham, Laurent Gil, Carlos García Girón, Leo Gordon, Thibaut Hourlier, Sarah E Hunt, Sophie H Janacek, Thomas Juettemann, Stephen Keenan, Matthew R Laird, Ilias Lavidas, Thomas Maurel, William McLaren, Benjamin Moore, Daniel N Murphy, Rishi Nag, Victoria Newman, Michael Nuhn, Chuang Kee Ong, Anne Parker, Mateus Patricio, Harpreet Singh Riat, Daniel Sheppard, Helen Sparrow, Kieron Taylor, Anja Thormann, Alessandro Vullo, Brandon Walts, Steven P Wilder, Amonida Zadissa, Myrto Kostadima, Fergal J Martin, Matthieu Muffato, Emily Perry, Magali Ruffier, Daniel M Staines, Stephen J Trevanion, Fiona Cunningham, Andrew Yates, Daniel R Zerbino, Paul Flicek
Ensembl (www.ensembl.org) is a database and genome browser for enabling research on vertebrate genomes. We import, analyse, curate and integrate a diverse collection of large-scale reference data to create a more comprehensive view of genome biology than would be possible from any individual dataset. Our extensive data resources include evidence-based gene and regulatory region annotation, genome variation and gene trees. An accompanying suite of tools, infrastructure and programmatic access methods ensure uniform data analysis and distribution for all supported species...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27899403/meta-analysis-of-genome-wide-association-studies-for-abdominal-aortic-aneurysm-identifies-four-new-disease-specific-risk-loci
#20
Gregory T Jones, Gerard Tromp, Helena Kuivaniemi, Solveig Gretarsdottir, Annette F Baas, Betti Giusti, Ewa Strauss, Femke N van 't Hof, Thomas Webb, Robert Erdman, Marylyn D Ritchie, James R Elmore, Anurag Verma, Sarah Pendergrass, Iftikhar J Kullo, Zi Ye, Peggy L Peissig, Omri Gottesman, Shefali S Verma, Jennifer Malinowski, Laura J Rasmussen-Torvik, Kenneth Borthwick, Diane T Smelser, David R Crosslin, Mariza de Andrade, Evan J Ryer, Catherine A McCarty, Erwin P Bottinger, Jennifer A Pacheco, Dana C Crawford, David S Carrell, Glenn S Gerhard, David P Franklin, David J Carey, Victoria L Phillips, Michael J Williams, Wenhua Wei, Ross Blair, Andrew A Hill, Thodur M Vasudevan, David R Lewis, Ian A Thomson, Jo Krysa, Geraldine B Hill, Justin Roake, Tony R Merriman, Grzegorz Oszkinis, Silvia Galora, Claudia Saracini, Rosanna Abbate, Raffaele Pulli, Carlo Pratesi, Athanasios Saratzis, Anna Verissimo, Suzannah J Bumpstead, Stephen A Badger, Rachel E Clough, Gillian W Cockerill, Hany Hafez, D J Scott, T S Futers, Simon P Romaine, Katherine Bridge, Kathryn J Griffin, Marc A Bailey, Alberto Smith, Matt M Thompson, Frank van Bockxmeer, Stefan E Matthiasson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jan D Blankensteijn, Joep A Teijink, Cisca Wijmenga, Jacqueline de Graaf, Lambertus A Kiemeney, Jes S Lindholt, Anne E Hughes, Declan T Bradley, Kathleen Stirrups, Jonathan Golledge, Paul E Norman, Janet T Powell, Steve E Humphries, Stephen E Hamby, Alison H Goodall, Christopher P Nelson, Natzi Sakalihasan, Audrey Courtois, Robert E Ferrell, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, John D Eicher, Andrew D Johnson, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric Schadt, Johan L Björkegren, Leonard Lipovich, Anne M Drolet, Eric Verhoeven, Clark J Zeebregts, Robert H Geelkerken, Marc R van Sambeek, Steven M van Sterkenburg, Jean-Paul P de Vries, Kari Stefansson, John R Thompson, Paul I de Bakker, Panos Deloukas, Robert D Sayers, Seamus Harrison, Andre M van Rij, Nilesh J Samani, Matthew J Bown
RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE: To identify additional AAA risk loci using data from all available genome-wide association studies (GWAS). METHODS AND RESULTS: Through a meta-analysis of 6 GWAS datasets and a validation study totalling 10,204 cases and 107,766 controls we identified 4 new AAA risk loci: 1q32...
November 29, 2016: Circulation Research
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