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https://www.readbyqxmd.com/read/29323105/enterovirus-d68-virus-like-particles-expressed-in-pichia-pastoris-potently-induce-neutralizing-antibody-responses-and-confer-protection-against-lethal-viral-infection-in-mice
#1
Chao Zhang, Xueyang Zhang, Wei Zhang, Wenlong Dai, Jing Xie, Liping Ye, Hongli Wang, Huan Chen, Qingwei Liu, Sitang Gong, Lanlan Geng, Zhong Huang
Enterovirus D68 (EV-D68) has been increasingly associated with severe respiratory illness and neurological complications in children worldwide. However, no vaccine is currently available to prevent EV-D68 infection. In the present study, we investigated the possibility of developing a virus-like particle (VLP)-based EV-D68 vaccine. We found that co-expression of the P1 precursor and 3CD protease of EV-D68 in Pichia pastoris yeast resulted in the generation of EV-D68 VLPs, which were composed of processed VP0, VP1, and VP3 capsid proteins and were visualized as ~30 nm spherical particles...
January 10, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29295756/a-virus-like-particle-vaccine-confers-protection-against-enterovirus-d68-lethal-challenge-in-mice
#2
Wenlong Dai, Chao Zhang, Xueyang Zhang, Pei Xiong, Qingwei Liu, Sitang Gong, Lanlan Geng, Dongming Zhou, Zhong Huang
Enterovirus D68 (EV-D68) is increasingly associated with severe acute respiratory infection and acute flaccid myelitis (AFM) in children around the world. However, neither vaccines nor therapeutic drugs are available for EV-D68. Here we report the development of a virus-like particle (VLP) based experimental EV-D68 vaccine. We found that EV-D68 VLPs could be successfully generated in insect cells infected with a recombinant baculovirus co-expressing the P1 precursor and 3CD protease of EV-D68. Biochemical and electron microscopic analyses revealed that EV-D68 VLPs were composed of VP0, VP1, and VP3 capsid proteins derived from precursor P1 and were visualized as spherical particles of ∼30 nm in diameter...
December 30, 2017: Vaccine
https://www.readbyqxmd.com/read/29290098/rotavirus-infection-as-a-frequent-cause-of-neonatal-fever
#3
Ha-Na Kang, Hyun Kyung Park, Hyun-Ju Lee, Jin-Hwa Moon, Jae Won Oh, Chang-Ryul Kim
BACKGROUND: Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus(RV) infection in our previous study. We investigated if RV infection is a major cause of neonatal fever and we compared the clinical characteristics of bacterial infections, viral infections and unknown causes of neonatal fever. METHOD: We reviewed the electronic medical records of 48 newborns of ≤ 28 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (≥ 38°C) from 2005 to 2009...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29282065/pulmonary-edema-following-central-nervous-system-lesions-induced-by-a-non-mouse-adapted-ev71-strain-in-neonatal-balb-c-mice
#4
Yuefei Jin, Chao Zhang, Rongguang Zhang, Jingchao Ren, Shuaiyin Chen, Meili Sui, Guangyuan Zhou, Dejian Dang, Jiehui Zhu, Huifen Feng, Yuanlin Xi, Haiyan Yang, Guangcai Duan
BACKGROUND: Enterovirus (EV) infection has been a serious health issue in Asia-Pacific region. It has been indicated that the occurrence of fatal hand foot and mouth disease (HFMD) cases following EV71 infection is mainly attributed to pulmonary edema. However, the development of pulmonary disorders after EV71 infection remains largely unknown. To establish an EV71-infected animal model and further explore the underlying association of central nervous system (CNS) invasion with pulmonary edema, we isolated a clinical source EV71 strain (ZZ1350) from a severe case in Henan Province...
December 28, 2017: Virology Journal
https://www.readbyqxmd.com/read/29205682/sibling-visitations-and-viral-infections-in-the-neonatal-intensive-care-unit
#5
Yuho Horikoshi, Kaoru Okazaki, Shigeko Miyokawa, Kazue Kinoshita, Hiroshi Higuchi, Junichi Suwa, Yuta Aizawa, Kahoru Fukuoka
BACKGROUND: Sibling visitations to the neonatal intensive care unit (NICU) are a part of family-centered care, which is now being increasingly endorsed as a positive development in patient care. However, sibling visitations pose a risk of viral infections such that many NICUs in Japan impose strict limits on the practice. The aim of our study was to assess whether sibling visitations to the NICU are related to an increase in the nosocomial viral infection rate. METHODS: This retrospective study was conducted between April 2012 and March 2017 at Tokyo Metropolitan Children's Medical Center in Japan...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29203935/viral-enteritis-in-calves
#6
REVIEW
Diego E Gomez, J Scott Weese
A complex community of bacteria, viruses, fungi, protists, and other microorganisms inhabit the gastrointestinal tract of calves and play important roles in gut health and disease. The viral component of the microbiome (the virome) is receiving increasing attention for its role in neonatal calf diarrhea (NCD). Rotavirus and coronavirus have for a long time been associated with NCD and commercial vaccines have been produced against these agents. Recently, several other viruses which may play a role in diarrhea have been discovered in calf fecal samples, mostly by sequence-based methods...
December 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29129453/hepatitis-b-virus-core-particles-containing-multiple-epitopes-confer-protection-against-enterovirus-71-and-coxsackievirus-a16-infection-in-mice
#7
Chunling Huo, Jie Yang, Lei Lei, Lei Qiao, Jiantao Xin, Zishu Pan
Human enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are the two major causative agents of hand-foot-and-mouth disease (HFMD). To investigate novel combined vaccines to prevent EV71 and CA16 infection, we constructed chimeric virus-like particles (tHBc/SPA or tHBc/SP VLPs) displaying conserved epitopes of EV71 (aa 208-222 of VP1 and aa 248-263 of VP2) and CA16 (aa271-285 of VP1) using a truncated hepatitis B virus core carrier (tHBc). Immunization with the chimeric VLPs induced epitope- or virus-specific IgG and neutralization antibodies against EV71 and CA16 in the mice...
December 19, 2017: Vaccine
https://www.readbyqxmd.com/read/29115952/no-evidence-of-enteric-viral-involvement-in-the-new-neonatal-porcine-diarrhoea-syndrome-in-danish-pigs
#8
N B Goecke, C K Hjulsager, H Kongsted, M Boye, S Rasmussen, F Granberg, T K Fischer, S E Midgley, L D Rasmussen, Ø Angen, J P Nielsen, S E Jorsal, L E Larsen
BACKGROUND: The aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral aetiology. Four well-managed herds experiencing neonatal diarrhoea and suspected to be affected by NNPDS were included in a case-control set up. A total of 989 piglets were clinically examined on a daily basis. Samples from diarrhoeic and non-diarrhoeic piglets at the age of three to seven days were selected for extensive virological examination using specific real time polymerase chain reactions (qPCRs) and general virus detection methods...
November 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29049234/case-report-features-of-hand-foot-and-mouth-disease-in-neonates
#9
Wen-Wen Chen, Zhao-Bin Yang, Lian-Shu Lian, Li-Ping Xu
RATIONALE: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions. PATIENT CONCERNS: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Blood, oropharyngeal fluid, urine, and cerebrospinal fluid (CSF) samples were collected and detected for further diagnoses with the consent of the infants' parents. Some of them suffered aseptic meningitis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28970319/extracorporeal-membrane-oxygenation-for-neonatal-collapse-caused-by-enterovirus-myocarditis
#10
Gerard Cortina, Derek Best, Markus Deisenberg, Roberto Chiletti, Warwick Butt
OBJECTIVE: To describe the effect of extracorporeal membrane oxygenation (ECMO) on survival and cardiac outcome of neonates with myocardial failure secondary to severe enterovirus (EV) myocarditis. DESIGN: Retrospective case series. SETTING: A 15-bed cardiac paediatric intensive care unit (ICU). PATIENTS: We describe the clinical presentations, cardiac findings, ECMO characteristics and outcome of seven neonates with severe EV myocarditis...
September 29, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28968718/evaluating-treatment-efficacy-in-a-mouse-model-of-enterovirus-d68-paralytic-myelitis
#11
Alison M Hixon, Penny Clarke, Kenneth L Tyler
Background: Enterovirus D68 (EV-D68) associated acute flaccid myelitis (AFM) is a devastating neurological disease for which there are no treatments of proven efficacy. The unpredictable temporal and geographic distribution of cases, and the rarity of the disease, make it unlikely that data from randomized controlled trials will be available to guide therapeutic decisions. We evaluated three widely used empiric therapies: (1) human intravenous immunoglobulin (hIVIG), (2) fluoxetine, and (3) dexamethasone, for the ability to reduce the severity of paralysis in a mouse model of EV-D68 infection...
September 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28944227/neonatal-enterovirus-myocarditis-with-severe-dystrophic-calcification-novel-treatment-with-pocapavir
#12
Samuel G Wittekind, Catherine C Allen, John L Jefferies, Mantosh S Rattan, Peace C Madueme, BreAnn N Taylor, Ryan A Moore
Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28822736/-rhinovirus-underestimated-pathogens-in-patients-during-the-neonatal-period
#13
S Zacharie, A Vabret, B Guillois, C Dupont, J Brouard
INTRODUCTION: In recent years, developments in virological tools have led to the easy detection of rhinoviruses and enteroviruses (E/RV). Their detection is very frequent in cases of airway involvement in children and their demonstrated causality. But the morbidity of E/RV in the neonatal period is unknown due to lack of epidemiological data. The objective of this study was to evaluate the incidence and clinical characteristics of these infections in hospitalized neonates. MATERIALS AND METHODS: We retrospectively analyzed the virology specimens of all neonates hospitalized at the Caen University Hospital between 2006 and 2011...
September 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28625478/a-neonatal-mouse-model-of-coxsackievirus-a10-infection-for-anti-viral-evaluation
#14
Shuxuan Li, Huan Zhao, Lisheng Yang, Wangheng Hou, Longfa Xu, Yangtao Wu, Wei Wang, Chunye Chen, Junkai Wan, Xiangzhong Ye, Zhenglun Liang, Qunying Mao, Tong Cheng, Ningshao Xia
Epidemiological data indicate that coxsackievirus A10 (CVA10) has become one of the main causative agents of hand, foot and mouth disease (HFMD) and in recent years has often been found to co-circulate with other enteroviruses, which poses a challenge for the prevention and control of HFMD. Although most CVA10-associated HFMD cases present mild symptoms, severe manifestations and even death can also occur. However, the study of the pathogenesis and the development of drugs and vaccines for CVA10 infection are still far from complete...
June 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28588119/high-flow-nasal-cannula-utilization-in-pediatric-critical-care
#15
Kristen D Coletti, Dayanand N Bagdure, Linda K Walker, Kenneth E Remy, Jason W Custer
BACKGROUND: High-flow nasal cannula (HFNC) is increasingly utilized in pediatrics, delivering humidified air and oxygen for respiratory conditions causing hypoxia and distress. In the neonatal ICU, it has been associated with better tolerance, lower complications, and lower cost. Few data exist regarding indications for use and the epidemiology of disease/pathology that warrants HFNC in the pediatric ICU. METHODS: This study is a retrospective cohort study of patients admitted to a tertiary children's hospital pediatric ICU and placed on HFNC from October 1, 2011 to October 31, 2013...
August 2017: Respiratory Care
https://www.readbyqxmd.com/read/28540257/dynamic-interaction-of-enterovirus-71-and-dendritic-cells-in-infected-neonatal-rhesus-macaques
#16
Ting Zhao, Zhixiao Zhang, Ying Zhang, Min Feng, Shengtao Fan, Lichun Wang, Longding Liu, Xi Wang, Qinglin Wang, Xiaolong Zhang, Jingjing Wang, Yun Liao, Zhanlong He, Shuaiyao Lu, Huai Yang, Qihan Li
Enterovirus 71 (EV71) is one of the main pathogens responsible for hand, foot, and mouth disease (HFMD). Infection with EV71 can lead to severe clinical disease via extensive infections of either the respiratory or alimentary tracts in children. Based on the previous pathological study of EV71 infections in neonatal rhesus macaques, our work using this animal model and an EV71 chimera that expresses enhanced green fluorescent protein (EGFP-EV71) primarily explored where EV71 localizes and proliferates, and the subsequent initiation of the pathological process...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28511987/human-parechovirus-type-3-infection-an-emerging-infection-in-neonates-and-young-infants
#17
REVIEW
Yuta Aizawa, Ryohei Izumita, Akihiko Saitoh
Human parechoviruses (HPeVs) are RNA viruses that have characteristics similar to those of enteroviruses and usually cause mild respiratory or gastrointestinal symptoms. Human parechovirus type 3 (HPeV3), first reported in 2004, is exceptional because it can provoke sepsis and meningoencephalitis leading to neurological sequelae, and even death, in neonates and young infants. Pediatricians and researchers are increasingly aware that HPeV3 is responsible for serious disease in neonates and young infants. Retrospective studies and several reports of epidemics of HPeV3 infection have provided data on epidemiology, clinical symptoms and signs, laboratory findings, and outcomes...
July 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28490584/a-naturally-occurring-recombinant-enterovirus-expresses-a-torovirus-deubiquitinase
#18
Pengcheng Shang, Saurav Misra, Ben Hause, Ying Fang
Enteroviruses (EVs) are implicated in a wide range of diseases in humans and animals. In this study, a novel enterovirus (enterovirus species G [EVG]) (EVG 08/NC_USA/2015) was isolated from a diagnostic sample from a neonatal pig diarrhea case and identified by using metagenomics and complete genome sequencing. The viral genome shares 75.4% nucleotide identity with a prototypic EVG strain (PEV9 UKG/410/73). Remarkably, a 582-nucleotide insertion, flanked by 3C(pro) cleavage sites at the 5' and 3' ends, was found in the 2C/3A junction region of the viral genome...
July 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28408118/a-novel-combined-vaccine-based-on-monochimeric-vlp-co-displaying-multiple-conserved-epitopes-against-enterovirus-71-and-varicella-zoster-virus
#19
Yangtao Wu, Rui Zhu, Longfa Xu, Yongchao Li, Shuxuan Li, Hai Yu, Shaowei Li, Hua Zhu, Tong Cheng, Ningshao Xia
Chicken pox and hand, foot and mouth disease (HFMD) are two major infectious diseases that mainly affect infants and children, causing significant morbidity annually. Varicella-zoster virus (VZV) and enterovirus 71 (EV71), respectively, are the principal epidemic pathogens causing these two diseases. To investigate the possibility of developing a novel combined vaccine to prevent chicken pox and HFMD, we constructed three chimeric virus-like particles (VLPs) (termed HBc-V/1/2, HBc-2/V/1 and HBc-1/2/V) based on the hepatitis B core antigen (HBc) carrier that display epitopes derived from VZV-gE, EV71-VP1, and EV71-VP2 in a varied tandem manner...
May 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28373042/-enterovirus-infection-during-pregnancy-underestimated-cause-of-fetal-and-neonatal-complications
#20
J Méreaux, O Picone, C Vauloup-Fellous, Z Khediri, A Benachi, L Mandelbrot, J-M Ayoubi
Enteroviruses are responsible for about one billion infections every year in the world. The clinical expression is in the vast majority asymptomatic cases (90%). Its consequences during pregnancy are rarely described. From the Medline database, we selected and analyzed 34 articles ranging from 1965 to 2015, to analyse the current knowledge of enterovirus infection consequences during pregnancy. We found that enterovirus infections may be the cause of fetal loss. The enterovirus infections during the 2nd and 3rd trimester may also lead to in utero fetal anomalies and death, but also to severe neonatal infections...
March 31, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
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