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Van der kolk, b

Esther H Lips, Rashmie Debipersad, Caroline E Scheerman, Lennart Mulder, Gabe S Sonke, Lizet E van der Kolk, Jelle Wesseling, Frans B L Hogervorst, Petra M Nederlof
Purpose As estrogen receptor (ER)-positive breast cancer in BRCA1 mutation carriers arises at an older age with less aggressive tumor characteristics than ER negative BRCA1 mutated breast cancer, it has been suggested that these tumors are 'sporadic' and not BRCA1-driven. With the introduction of targeted treatments specific for tumors with a non-functioning BRCA1 or BRCA2 gene, the question whether the BRCA genes are impaired in the tumor, is highly relevant. Therefore, we performed genomic profiling of BRCA1-mutated ER+ tumors...
September 12, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Marjanka K Schmidt, Frans Hogervorst, Richard van Hien, Sten Cornelissen, Annegien Broeks, Muriel A Adank, Hanne Meijers, Quinten Waisfisz, Antoinette Hollestelle, Mieke Schutte, Ans van den Ouweland, Maartje Hooning, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Antonis C Antoniou, Volker Arndt, Marina Bermisheva, Natalia V Bogdanova, Manjeet K Bolla, Hiltrud Brauch, Hermann Brenner, Thomas Brüning, Barbara Burwinkel, Jenny Chang-Claude, Georgia Chenevix-Trench, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Alison M Dunning, Peter A Fasching, Jonine Figueroa, Olivia Fletcher, Henrik Flyger, Eva Galle, Montserrat García-Closas, Graham G Giles, Lothar Haeberle, Per Hall, Peter Hillemanns, John L Hopper, Anna Jakubowska, Esther M John, Michael Jones, Elza Khusnutdinova, Julia A Knight, Veli-Matti Kosma, Vessela Kristensen, Andrew Lee, Annika Lindblom, Jan Lubinski, Arto Mannermaa, Sara Margolin, Alfons Meindl, Roger L Milne, Taru A Muranen, Polly A Newcomb, Kenneth Offit, Tjoung-Won Park-Simon, Julian Peto, Paul D P Pharoah, Mark Robson, Anja Rudolph, Elinor J Sawyer, Rita K Schmutzler, Caroline Seynaeve, Julie Soens, Melissa C Southey, Amanda B Spurdle, Harald Surowy, Anthony Swerdlow, Rob A E M Tollenaar, Ian Tomlinson, Amy Trentham-Dietz, Celine Vachon, Qin Wang, Alice S Whittemore, Argyrios Ziogas, Lizet van der Kolk, Heli Nevanlinna, Thilo Dörk, Stig Bojesen, Douglas F Easton
PURPOSE: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Eva Versteijne, Casper H J van Eijck, Cornelis J A Punt, Mustafa Suker, Aeilko H Zwinderman, Miriam A C Dohmen, Karin B C Groothuis, Oliver R C Busch, Marc G H Besselink, Ignace H J T de Hingh, Albert J Ten Tije, Gijs A Patijn, Bert A Bonsing, Judith de Vos-Geelen, Joost M Klaase, Sebastiaan Festen, Djamila Boerma, Joris I Erdmann, I Quintus Molenaar, Erwin van der Harst, Marion B van der Kolk, Coen R N Rasch, Geertjan van Tienhoven
BACKGROUND: Pancreatic cancer is the fourth largest cause of cancer death in the United States and Europe with over 100,000 deaths per year in Europe alone. The overall 5-year survival ranges from 2-7 % and has hardly improved over the last two decades. Approximately 15 % of all patients have resectable disease at diagnosis, and of those, only a subgroup has a resectable tumour at surgical exploration. Data from cohort studies have suggested that outcome can be improved by preoperative radiochemotherapy, but data from well-designed randomized studies are lacking...
2016: Trials
L C Hardeman, B R van der Meij, W Back, J H van der Kolk, I D Wijnberg
BACKGROUND: In equine laminitis, the deep digital flexor muscle (DDFM) appears to have increased muscle force, but evidence-based confirmation is lacking. OBJECTIVES: The purpose of this study was to test if the DDFM of laminitic equines has an increased muscle force detectable by needle electromyography interference pattern analysis (IPA). ANIMALS AND METHODS: The control group included six Royal Dutch Sport horses, three Shetland ponies and one Welsh pony [10 healthy, sound adults weighing 411 ± 217 kg (mean ± SD) and aged 10 ± 5 years]...
2016: Veterinary Quarterly
M Achten-Weiler, E J B Veldhuis Kroeze, S Boerma, J H van der Kolk
No abstract text is available yet for this article.
June 2016: Veterinary Quarterly
L C Hardeman, B R van der Meij, W Back, J H van der Kolk, I D Wijnberg
REASONS FOR PERFORMING STUDY: In cases of laminitis, an increased muscle force or contracture of the deep digital flexor muscle (DDFM) is suggested, but evidence-based research is lacking. OBJECTIVES: To test if the DDFM of laminitic equines shows an increased muscle force detectable by needle-EMG including Interference Pattern Analysis (IPA). STUDY DESIGN: Cross-sectional study. METHODS: Three groups consisted of Group 0 (control): 6 Royal Dutch Sport horses, 3 Shetland ponies and one Welsh pony (healthy, sound adults, mean ± s...
September 2015: Equine Veterinary Journal
Rachel S van der Post, Ingrid P Vogelaar, Peggy Manders, Lizet E van der Kolk, Annemieke Cats, Liselotte P van Hest, Rolf Sijmons, Cora M Aalfs, Margreet G E M Ausems, Encarna B Gómez García, Anja Wagner, Frederik J Hes, Neeltje Arts, Arjen R Mensenkamp, J Han van Krieken, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg
BACKGROUND & AIMS: Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1) cause a predisposition to gastric cancer. We evaluated the ability of the internationally accepted hereditary diffuse gastric cancer (HDGC) criteria to identify individuals with pathogenic mutations in CDH1, and assessed their outcomes. The criteria were as follows: families with 2 or more cases of gastric cancer, with at least 1 patient diagnosed with diffuse gastric cancer (DGC) before age 50; families with 3 or more cases of DGC; families with 1 DGC before the age of 40; and families with a history of DGC and lobular breast cancer, with 1 diagnosis before the age of 50...
October 2015: Gastroenterology
Alexandra A J de Rotte, Martine T B Truijman, Anouk C van Dijk, Madieke I Liem, Floris H B M Schreuder, Anja G van der Kolk, Jelle R de Kruijk, Matt J A P Daemen, Anton F W van der Steen, Gert Jan de Borst, Peter R Luijten, Paul J Nederkoorn, Marianne Eline Kooi, Aad van der Lugt, Jeroen Hendrikse
BACKGROUND AND PURPOSE: Carotid plaque composition is a major determinant of cerebrovascular events. In the present analysis, we evaluated the relationship between intraplaque hemorrhage (IPH) and a thin/ruptured fibrous cap (TRFC) in moderately stenosed carotid arteries and cerebral infarcts on MRI in the ipsilateral hemisphere. METHODS: A total of 101 patients with a symptomatic 30% to 69% carotid artery stenosis underwent MRI of the carotid arteries and the brain, within a median time of 45 days from onset of symptoms...
February 2015: Stroke; a Journal of Cerebral Circulation
L C Hardeman, B R van der Meij, A A H Lamers, J H van der Kolk, W Back, I D Wijnberg
In equine medicine the use of Botox® is experimental. Dosages are determined from human treatment-protocols and limited numbers of equine studies. Determination of target-muscle volume can be helpful to extrapolate human dosages. The aim of the study was to calculate a formula enabling the estimation of the deep digital flexor muscle (DDFM) volume based on distances between anatomical landmarks. Nineteen cadaveric limbs were collected and distance A (top of olecranon to Os carpi accessorium) and B (circumference of limb) were measured...
October 2014: Research in Veterinary Science
B Abelev, J Adam, D Adamová, A M Adare, M M Aggarwal, G Aglieri Rinella, A G Agocs, A Agostinelli, S Aguilar Salazar, Z Ahammed, A Ahmad Masoodi, N Ahmad, S A Ahn, S U Ahn, A Akindinov, D Aleksandrov, B Alessandro, R Alfaro Molina, A Alici, A Alkin, E Almaráz Aviña, J Alme, T Alt, V Altini, S Altinpinar, I Altsybeev, C Andrei, A Andronic, V Anguelov, J Anielski, C Anson, T Antičić, F Antinori, P Antonioli, L Aphecetche, H Appelshäuser, N Arbor, S Arcelli, A Arend, N Armesto, R Arnaldi, T Aronsson, I C Arsene, M Arslandok, A Asryan, A Augustinus, R Averbeck, T C Awes, J Äystö, M D Azmi, M Bach, A Badalà, Y W Baek, R Bailhache, R Bala, R Baldini Ferroli, A Baldisseri, A Baldit, F Baltasar Dos Santos Pedrosa, J Bán, R C Baral, R Barbera, F Barile, G G Barnaföldi, L S Barnby, V Barret, J Bartke, M Basile, N Bastid, S Basu, B Bathen, G Batigne, B Batyunya, C Baumann, I G Bearden, H Beck, N K Behera, I Belikov, F Bellini, R Bellwied, E Belmont-Moreno, G Bencedi, S Beole, I Berceanu, A Bercuci, Y Berdnikov, D Berenyi, A A E Bergognon, D Berzano, L Betev, A Bhasin, A K Bhati, J Bhom, L Bianchi, N Bianchi, C Bianchin, J Bielčík, J Bielčíková, A Bilandzic, S Bjelogrlic, F Blanco, F Blanco, D Blau, C Blume, M Boccioli, N Bock, S Böttger, A Bogdanov, H Bøggild, M Bogolyubsky, L Boldizsár, M Bombara, J Book, H Borel, A Borissov, S Bose, F Bossú, M Botje, B Boyer, E Braidot, P Braun-Munzinger, M Bregant, T Breitner, T A Browning, M Broz, R Brun, E Bruna, G E Bruno, D Budnikov, H Buesching, S Bufalino, K Bugaiev, O Busch, Z Buthelezi, D Caballero Orduna, D Caffarri, X Cai, H Caines, E Calvo Villar, P Camerini, V Canoa Roman, G Cara Romeo, F Carena, W Carena, N Carlin Filho, F Carminati, C A Carrillo Montoya, A Casanova Díaz, J Castillo Castellanos, J F Castillo Hernandez, E A R Casula, V Catanescu, C Cavicchioli, C Ceballos Sanchez, J Cepila, P Cerello, B Chang, S Chapeland, J L Charvet, S Chattopadhyay, S Chattopadhyay, I Chawla, M Cherney, C Cheshkov, B Cheynis, V Chibante Barroso, D D Chinellato, P Chochula, M Chojnacki, S Choudhury, P Christakoglou, C H Christensen, P Christiansen, T Chujo, S U Chung, C Cicalo, L Cifarelli, F Cindolo, J Cleymans, F Coccetti, F Colamaria, D Colella, G Conesa Balbastre, Z Conesa del Valle, P Constantin, G Contin, J G Contreras, T M Cormier, Y Corrales Morales, P Cortese, I Cortés Maldonado, M R Cosentino, F Costa, M E Cotallo, E Crescio, P Crochet, E Cruz Alaniz, E Cuautle, L Cunqueiro, A Dainese, H H Dalsgaard, A Danu, D Das, I Das, K Das, S Dash, A Dash, S De, G O V de Barros, A De Caro, G de Cataldo, J de Cuveland, A De Falco, D De Gruttola, H Delagrange, A Deloff, V Demanov, N De Marco, E Dénes, S De Pasquale, A Deppman, G D Erasmo, R de Rooij, M A Diaz Corchero, D Di Bari, T Dietel, S Di Liberto, A Di Mauro, P Di Nezza, R Divià, Ø Djuvsland, A Dobrin, T Dobrowolski, I Domínguez, B Dönigus, O Dordic, O Driga, A K Dubey, L Ducroux, P Dupieux, M R Dutta Majumdar, A K Dutta Majumdar, D Elia, D Emschermann, H Engel, H A Erdal, B Espagnon, M Estienne, S Esumi, D Evans, G Eyyubova, D Fabris, J Faivre, D Falchieri, A Fantoni, M Fasel, R Fearick, A Fedunov, D Fehlker, L Feldkamp, D Felea, B Fenton-Olsen, G Feofilov, A Fernández Téllez, A Ferretti, R Ferretti, J Figiel, M A S Figueredo, S Filchagin, D Finogeev, F M Fionda, E M Fiore, M Floris, S Foertsch, P Foka, S Fokin, E Fragiacomo, U Frankenfeld, U Fuchs, C Furget, M Fusco Girard, J J Gaardhøje, M Gagliardi, A Gago, M Gallio, D R Gangadharan, P Ganoti, C Garabatos, E Garcia-Solis, I Garishvili, J Gerhard, M Germain, C Geuna, A Gheata, M Gheata, B Ghidini, P Ghosh, C Di Giglio, P Gianotti, M R Girard, P Giubellino, E Gladysz-Dziadus, P Glässel, R Gomez, A Gonschior, E G Ferreiro, L H González-Trueba, P González-Zamora, S Gorbunov, A Goswami, S Gotovac, V Grabski, L K Graczykowski, R Grajcarek, A Grelli, C Grigoras, A Grigoras, V Grigoriev, A Grigoryan, S Grigoryan, B Grinyov, N Grion, P Gros, J F Grosse-Oetringhaus, J-Y Grossiord, R Grosso, F Guber, R Guernane, C Guerra Gutierrez, B Guerzoni, M Guilbaud, K Gulbrandsen, T Gunji, A Gupta, R Gupta, H Gutbrod, Ø Haaland, C Hadjidakis, M Haiduc, H Hamagaki, G Hamar, B H Han, L D Hanratty, A Hansen, Z Harmanova, J W Harris, M Hartig, D Hasegan, D Hatzifotiadou, A Hayrapetyan, S T Heckel, M Heide, H Helstrup, A Herghelegiu, G Herrera Corral, N Herrmann, B A Hess, K F Hetland, B Hicks, P T Hille, B Hippolyte, T Horaguchi, Y Hori, P Hristov, I Hřivnáčová, M Huang, T J Humanic, D S Hwang, R Ichou, R Ilkaev, I Ilkiv, M Inaba, E Incani, G M Innocenti, P G Innocenti, M Ippolitov, M Irfan, C Ivan, V Ivanov, M Ivanov, A Ivanov, O Ivanytskyi, A Jachołkowski, P M Jacobs, H J Jang, S Jangal, M A Janik, R Janik, P H S Y Jayarathna, S Jena, D M Jha, R T Jimenez Bustamante, L Jirden, P G Jones, H Jung, A Jusko, A B Kaidalov, V Kakoyan, S Kalcher, P Kaliňák, T Kalliokoski, A Kalweit, K Kanaki, J H Kang, V Kaplin, A Karasu Uysal, O Karavichev, T Karavicheva, E Karpechev, A Kazantsev, U Kebschull, R Keidel, P Khan, M M Khan, S A Khan, A Khanzadeev, Y Kharlov, B Kileng, D W Kim, M Kim, M Kim, S H Kim, D J Kim, S Kim, J H Kim, J S Kim, B Kim, T Kim, S Kirsch, I Kisel, S Kiselev, A Kisiel, J L Klay, J Klein, C Klein-Bösing, M Kliemant, A Kluge, M L Knichel, A G Knospe, K Koch, M K Köhler, A Kolojvari, V Kondratiev, N Kondratyeva, A Konevskikh, A Korneev, R Kour, M Kowalski, S Kox, G Koyithatta Meethaleveedu, J Kral, I Králik, F Kramer, I Kraus, T Krawutschke, M Krelina, M Kretz, M Krivda, F Krizek, M Krus, E Kryshen, M Krzewicki, Y Kucheriaev, C Kuhn, P G Kuijer, I Kulakov, J Kumar, P Kurashvili, A B Kurepin, A Kurepin, A Kuryakin, V Kushpil, S Kushpil, H Kvaerno, M J Kweon, Y Kwon, P Ladrón de Guevara, I Lakomov, R Langoy, S L La Pointe, C Lara, A Lardeux, P La Rocca, C Lazzeroni, R Lea, Y Le Bornec, M Lechman, S C Lee, K S Lee, G R Lee, F Lefèvre, J Lehnert, L Leistam, M Lenhardt, V Lenti, H León, M Leoncino, I León Monzón, H León Vargas, P Lévai, J Lien, R Lietava, S Lindal, V Lindenstruth, C Lippmann, M A Lisa, L Liu, P I Loenne, V R Loggins, V Loginov, S Lohn, D Lohner, C Loizides, K K Loo, X Lopez, E López Torres, G Løvhøiden, X-G Lu, P Luettig, M Lunardon, J Luo, G Luparello, L Luquin, C Luzzi, R Ma, K Ma, D M Madagodahettige-Don, A Maevskaya, M Mager, D P Mahapatra, A Maire, M Malaev, I Maldonado Cervantes, L Malinina, D Mal'Kevich, P Malzacher, A Mamonov, L Manceau, L Mangotra, V Manko, F Manso, V Manzari, Y Mao, M Marchisone, J Mareš, G V Margagliotti, A Margotti, A Marín, C A Marin Tobon, C Markert, I Martashvili, P Martinengo, M I Martínez, A Martínez Davalos, G Martínez García, Y Martynov, A Mas, S Masciocchi, M Masera, A Masoni, L Massacrier, M Mastromarco, A Mastroserio, Z L Matthews, A Matyja, D Mayani, C Mayer, J Mazer, M A Mazzoni, F Meddi, A Menchaca-Rocha, J Mercado Pérez, M Meres, Y Miake, L Milano, J Milosevic, A Mischke, A N Mishra, D Miśkowiec, C Mitu, J Mlynarz, B Mohanty, A K Mohanty, L Molnar, L Montaño Zetina, M Monteno, E Montes, T Moon, M Morando, D A Moreira De Godoy, S Moretto, A Morsch, V Muccifora, E Mudnic, S Muhuri, M Mukherjee, H Müller, M G Munhoz, L Musa, A Musso, B K Nandi, R Nania, E Nappi, C Nattrass, N P Naumov, S Navin, T K Nayak, S Nazarenko, G Nazarov, A Nedosekin, M Nicassio, M Niculescu, B S Nielsen, T Niida, S Nikolaev, V Nikolic, S Nikulin, V Nikulin, B S Nilsen, M S Nilsson, F Noferini, P Nomokonov, G Nooren, N Novitzky, A Nyanin, A Nyatha, C Nygaard, J Nystrand, A Ochirov, H Oeschler, S Oh, S K Oh, J Oleniacz, C Oppedisano, A Ortiz Velasquez, G Ortona, A Oskarsson, P Ostrowski, J Otwinowski, K Oyama, K Ozawa, Y Pachmayer, M Pachr, F Padilla, P Pagano, G Paić, F Painke, C Pajares, S Pal, S K Pal, A Palaha, A Palmeri, V Papikyan, G S Pappalardo, W J Park, A Passfeld, B Pastirčák, D I Patalakha, V Paticchio, A Pavlinov, T Pawlak, T Peitzmann, H Pereira Da Costa, E Pereira De Oliveira Filho, D Peresunko, C E Pérez Lara, E Perez Lezama, D Perini, D Perrino, W Peryt, A Pesci, V Peskov, Y Pestov, V Petráček, M Petran, M Petris, P Petrov, M Petrovici, C Petta, S Piano, A Piccotti, M Pikna, P Pillot, O Pinazza, L Pinsky, N Pitz, D B Piyarathna, M Płoskoń, J Pluta, T Pocheptsov, S Pochybova, P L M Podesta-Lerma, M G Poghosyan, K Polák, B Polichtchouk, A Pop, S Porteboeuf-Houssais, V Pospíšil, B Potukuchi, S K Prasad, R Preghenella, F Prino, C A Pruneau, I Pshenichnov, S Puchagin, G Puddu, J Pujol Teixido, A Pulvirenti, V Punin, M Putiš, J Putschke, E Quercigh, H Qvigstad, A Rachevski, A Rademakers, S Radomski, T S Räihä, J Rak, A Rakotozafindrabe, L Ramello, A Ramírez Reyes, S Raniwala, R Raniwala, S S Räsänen, B T Rascanu, D Rathee, K F Read, J S Real, K Redlich, P Reichelt, M Reicher, R Renfordt, A R Reolon, A Reshetin, F Rettig, J-P Revol, K Reygers, L Riccati, R A Ricci, T Richert, M Richter, P Riedler, W Riegler, F Riggi, B Rodrigues Fernandes Rabacal, M Rodríguez Cahuantzi, A Rodriguez Manso, K Røed, D Rohr, D Röhrich, R Romita, F Ronchetti, P Rosnet, S Rossegger, A Rossi, C Roy, P Roy, A J Rubio Montero, R Rui, E Ryabinkin, A Rybicki, S Sadovsky, K Šafařík, R Sahoo, P K Sahu, J Saini, H Sakaguchi, S Sakai, D Sakata, C A Salgado, J Salzwedel, S Sambyal, V Samsonov, X Sanchez Castro, L Šándor, A Sandoval, S Sano, M Sano, R Santo, R Santoro, J Sarkamo, E Scapparone, F Scarlassara, R P Scharenberg, C Schiaua, R Schicker, C Schmidt, H R Schmidt, S Schreiner, S Schuchmann, J Schukraft, Y Schutz, K Schwarz, K Schweda, G Scioli, E Scomparin, R Scott, P A Scott, G Segato, I Selyuzhenkov, S Senyukov, J Seo, S Serci, E Serradilla, A Sevcenco, A Shabetai, G Shabratova, R Shahoyan, N Sharma, S Sharma, S Rohni, K Shigaki, M Shimomura, K Shtejer, Y Sibiriak, M Siciliano, E Sicking, S Siddhanta, T Siemiarczuk, D Silvermyr, C Silvestre, G Simatovic, G Simonetti, R Singaraju, R Singh, S Singha, V Singhal, T Sinha, B C Sinha, B Sitar, M Sitta, T B Skaali, K Skjerdal, R Smakal, N Smirnov, R J M Snellings, C Søgaard, R Soltz, H Son, M Song, J Song, C Soos, F Soramel, I Sputowska, M Spyropoulou-Stassinaki, B K Srivastava, J Stachel, I Stan, I Stan, G Stefanek, T Steinbeck, M Steinpreis, E Stenlund, G Steyn, J H Stiller, D Stocco, M Stolpovskiy, K Strabykin, P Strmen, A A P Suaide, M A Subieta Vásquez, T Sugitate, C Suire, M Sukhorukov, R Sultanov, M Šumbera, T Susa, A Szanto de Toledo, I Szarka, A Szczepankiewicz, A Szostak, M Szymanski, J Takahashi, J D Tapia Takaki, A Tauro, G Tejeda Muñoz, A Telesca, C Terrevoli, J Thäder, D Thomas, R Tieulent, A R Timmins, D Tlusty, A Toia, H Torii, L Toscano, D Truesdale, W H Trzaska, T Tsuji, A Tumkin, R Turrisi, T S Tveter, J Ulery, K Ullaland, J Ulrich, A Uras, J Urbán, G M Urciuoli, G L Usai, M Vajzer, M Vala, L Valencia Palomo, S Vallero, N van der Kolk, P Vande Vyvre, M van Leeuwen, L Vannucci, A Vargas, R Varma, M Vasileiou, A Vasiliev, V Vechernin, M Veldhoen, M Venaruzzo, E Vercellin, S Vergara, R Vernet, M Verweij, L Vickovic, G Viesti, O Vikhlyantsev, Z Vilakazi, O Villalobos Baillie, A Vinogradov, L Vinogradov, Y Vinogradov, T Virgili, Y P Viyogi, A Vodopyanov, K Voloshin, S Voloshin, G Volpe, B von Haller, D Vranic, G Øvrebekk, J Vrláková, B Vulpescu, A Vyushin, V Wagner, B Wagner, R Wan, M Wang, D Wang, Y Wang, Y Wang, K Watanabe, M Weber, J P Wessels, U Westerhoff, J Wiechula, J Wikne, M Wilde, G Wilk, A Wilk, M C S Williams, B Windelband, L Xaplanteris Karampatsos, C G Yaldo, Y Yamaguchi, H Yang, S Yang, S Yasnopolskiy, J Yi, Z Yin, I-K Yoo, J Yoon, W Yu, X Yuan, I Yushmanov, C Zach, C Zampolli, S Zaporozhets, A Zarochentsev, P Závada, N Zaviyalov, H Zbroszczyk, P Zelnicek, I S Zgura, M Zhalov, X Zhang, H Zhang, F Zhou, D Zhou, Y Zhou, J Zhu, J Zhu, X Zhu, A Zichichi, A Zimmermann, G Zinovjev, Y Zoccarato, M Zynovyev, M Zyzak
We report the first measurement of the net-charge fluctuations in Pb-Pb collisions at sqrt[sNN]=2.76  TeV, measured with the ALICE detector at the CERN Large Hadron Collider. The dynamical fluctuations per unit entropy are observed to decrease when going from peripheral to central collisions. An additional reduction in the amount of fluctuations is seen in comparison to the results from lower energies. We examine the dependence of fluctuations on the pseudorapidity interval, which may account for the dilution of fluctuations during the evolution of the system...
April 12, 2013: Physical Review Letters
Ellen Y M Ma, Frendi W S Li
The present study examined the relevance of the developmental trauma disorder (DTD) framework (van der Kolk, ) in Hong Kong Chinese children with repeated familial physical and/or sexual abuse. Self-reports of (a) key dimensions of DTD including emotion regulation, attribution and perceptions in self and relationships, belief in future victimization, behavioral difficulties, and self-esteem; and (b) attachment styles and posttraumatic stress disorder (PTSD) reactions were obtained from children aged 9-15 years in clinical and school settings...
August 2014: Journal of Traumatic Stress
Janet R Vos, Natalia Teixeira, Dorina M van der Kolk, Marian J E Mourits, Matti A Rookus, Flora E van Leeuwen, Margriet Collée, Christi J van Asperen, Arjen R Mensenkamp, Margreet G E M Ausems, Theo A M van Os, Hanne E J Meijers-Heijboer, Encarna B Gómez-Garcia, Hans F Vasen, Richard M Brohet, Annemarie H van der Hout, Liesbeth Jansen, Jan C Oosterwijk, Geertruida H de Bock
BACKGROUND: We aimed to quantify previously observed relatively high cancer risks in BRCA2 mutation carriers (BRCA2 carriers) older than 60 in the Northern Netherlands, and to analyze whether these could be explained by mutation spectrum or population background risk. METHODS: This consecutive cohort study included all known pathogenic BRCA1/2 carriers in the Northern Netherlands (N = 1,050). Carrier and general reference populations were: BRCA1/2 carriers in the rest of the Netherlands (N = 2,013) and the general population in both regions...
November 2014: Cancer Epidemiology, Biomarkers & Prevention
Bessel A van der Kolk, Laura Stone, Jennifer West, Alison Rhodes, David Emerson, Michael Suvak, Joseph Spinazzola
BACKGROUND: More than a third of the approximately 10 million women with histories of interpersonal violence in the United States develop posttraumatic stress disorder (PTSD). Currently available treatments for this population have a high rate of incomplete response, in part because problems in affect and impulse regulation are major obstacles to resolving PTSD. This study explored the efficacy of yoga to increase affect tolerance and to decrease PTSD symptomatology. METHOD: Sixty-four women with chronic, treatment-resistant PTSD were randomly assigned to either trauma-informed yoga or supportive women's health education, each as a weekly 1-hour class for 10 weeks...
June 2014: Journal of Clinical Psychiatry
Ana Osorio, Roger L Milne, Karoline Kuchenbaecker, Tereza Vaclová, Guillermo Pita, Rosario Alonso, Paolo Peterlongo, Ignacio Blanco, Miguel de la Hoya, Mercedes Duran, Orland Díez, Teresa Ramón Y Cajal, Irene Konstantopoulou, Cristina Martínez-Bouzas, Raquel Andrés Conejero, Penny Soucy, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Swe-Brca, Brita Arver, Johanna Rantala, Niklas Loman, Hans Ehrencrona, Olufunmilayo I Olopade, Mary S Beattie, Susan M Domchek, Katherine Nathanson, Timothy R Rebbeck, Banu K Arun, Beth Y Karlan, Christine Walsh, Jenny Lester, Esther M John, Alice S Whittemore, Mary B Daly, Melissa Southey, John Hopper, Mary B Terry, Saundra S Buys, Ramunas Janavicius, Cecilia M Dorfling, Elizabeth J van Rensburg, Linda Steele, Susan L Neuhausen, Yuan Chun Ding, Thomas V O Hansen, Lars Jønson, Bent Ejlertsen, Anne-Marie Gerdes, Mar Infante, Belén Herráez, Leticia Thais Moreno, Jeffrey N Weitzel, Josef Herzog, Kisa Weeman, Siranoush Manoukian, Bernard Peissel, Daniela Zaffaroni, Giulietta Scuvera, Bernardo Bonanni, Frederique Mariette, Sara Volorio, Alessandra Viel, Liliana Varesco, Laura Papi, Laura Ottini, Maria Grazia Tibiletti, Paolo Radice, Drakoulis Yannoukakos, Judy Garber, Steve Ellis, Debra Frost, Radka Platte, Elena Fineberg, Gareth Evans, Fiona Lalloo, Louise Izatt, Ros Eeles, Julian Adlard, Rosemarie Davidson, Trevor Cole, Diana Eccles, Jackie Cook, Shirley Hodgson, Carole Brewer, Marc Tischkowitz, Fiona Douglas, Mary Porteous, Lucy Side, Lisa Walker, Patrick Morrison, Alan Donaldson, John Kennedy, Claire Foo, Andrew K Godwin, Rita Katharina Schmutzler, Barbara Wappenschmidt, Kerstin Rhiem, Christoph Engel, Alfons Meindl, Nina Ditsch, Norbert Arnold, Hans Jörg Plendl, Dieter Niederacher, Christian Sutter, Shan Wang-Gohrke, Doris Steinemann, Sabine Preisler-Adams, Karin Kast, Raymonda Varon-Mateeva, Andrea Gehrig, Dominique Stoppa-Lyonnet, Olga M Sinilnikova, Sylvie Mazoyer, Francesca Damiola, Bruce Poppe, Kathleen Claes, Marion Piedmonte, Kathy Tucker, Floor Backes, Gustavo Rodríguez, Wendy Brewster, Katie Wakeley, Thomas Rutherford, Trinidad Caldés, Heli Nevanlinna, Kristiina Aittomäki, Matti A Rookus, Theo A M van Os, Lizet van der Kolk, J L de Lange, Hanne E J Meijers-Heijboer, A H van der Hout, Christi J van Asperen, Encarna B Gómez Garcia, Nicoline Hoogerbrugge, J Margriet Collée, Carolien H M van Deurzen, Rob B van der Luijt, Peter Devilee, Hebon, Edith Olah, Conxi Lázaro, Alex Teulé, Mireia Menéndez, Anna Jakubowska, Cezary Cybulski, Jacek Gronwald, Jan Lubinski, Katarzyna Durda, Katarzyna Jaworska-Bieniek, Oskar Th Johannsson, Christine Maugard, Marco Montagna, Silvia Tognazzo, Manuel R Teixeira, Sue Healey, Kconfab Investigators, Curtis Olswold, Lucia Guidugli, Noralane Lindor, Susan Slager, Csilla I Szabo, Joseph Vijai, Mark Robson, Noah Kauff, Liying Zhang, Rohini Rau-Murthy, Anneliese Fink-Retter, Christian F Singer, Christine Rappaport, Daphne Geschwantler Kaulich, Georg Pfeiler, Muy-Kheng Tea, Andreas Berger, Catherine M Phelan, Mark H Greene, Phuong L Mai, Flavio Lejbkowicz, Irene Andrulis, Anna Marie Mulligan, Gord Glendon, Amanda Ewart Toland, Anders Bojesen, Inge Sokilde Pedersen, Lone Sunde, Mads Thomassen, Torben A Kruse, Uffe Birk Jensen, Eitan Friedman, Yael Laitman, Shani Paluch Shimon, Jacques Simard, Douglas F Easton, Kenneth Offit, Fergus J Couch, Georgia Chenevix-Trench, Antonis C Antoniou, Javier Benitez
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers...
April 2014: PLoS Genetics
Rachel Wamser-Nanney, Brian R Vandenberg
Complex trauma events have been defined as chronic, interpersonal traumas that begin early in life (Cook, Blaustein, Spinazzola, & van der Kolk, 2003). The complex trauma definition has been examined in adults, as indicated by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) field trial; however, this research was lacking in child populations. The symptom presentations of complexly traumatized children were contrasted with those exposed to other, less severe trauma ecologies that met 1 or 2 features of the complex trauma definition...
December 2013: Journal of Traumatic Stress
Molly K McDonald, Cameo F Borntrager, Whitney Rostad
The current definition of a traumatic event in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5; American Psychiatric Association, 2013) may be too narrow to describe the myriad of difficult childhood experiences. Furthermore, youth may develop a distinct pattern of symptoms in relation to complex or multiple childhood trauma experiences, the proposed developmental trauma disorder (DTD; B. A. van der Kolk, 2005 ) We developed and utilized a new measure, the Potentially Traumatic Experiences Questionnaire (PTEQ), to assess patterns in childhood trauma exposure...
2014: Journal of Trauma & Dissociation
M Oosterlinck, L C Hardeman, B R van der Meij, S Veraa, J H van der Kolk, I D Wijnberg, F Pille, W Back
Empirically, equine distal limb lameness is often linked to hoof imbalance. To objectively quantify dynamic toe-heel and medio-lateral hoof balance of the vertical ground reaction force in sound sport horses, seven Royal Dutch Sport Horses were led at the walk and trot over a dynamically calibrated pressure plate. Forelimb hoof prints were divided into a toe and heel region and a medial and lateral zone. Toe-heel and medio-lateral hoof balance of the vertical ground reaction force were calculated throughout the stance...
December 2013: Veterinary Journal
M T B Truijman, M E Kooi, A C van Dijk, A A J de Rotte, A G van der Kolk, M I Liem, F H B M Schreuder, E Boersma, W H Mess, R J van Oostenbrugge, P J Koudstaal, L J Kappelle, P J Nederkoorn, A J Nederveen, J Hendrikse, A F W van der Steen, M J A P Daemen, A van der Lugt
BACKGROUND: Patients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. AIMS AND HYPOTHESIS: We investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector-row computed tomography angiography, ultrasonography, and transcranial Doppler, either alone or in combination, may improve identification of a subgroup of patients with < 70% carotid artery stenosis with an increased risk of recurrent stroke...
August 2014: International Journal of Stroke: Official Journal of the International Stroke Society
S C Wijers, B Y M van der Kolk, A E Tuinenburg, P A F Doevendans, M A Vos, M Meine
PURPOSE: Based on multiple large clinical trials conducted over the last decades guidelines for implantable cardioverter-defibrillator (ICD) implantations have been evolving. The increase in primary prophylactic ICD implantations challenges us to be critical towards the indications in certain patient populations. METHODS: We retrospectively collected patient characteristics and rates of appropriate and inappropriate ICD therapy, appropriate and inappropriate ICD shock and mortality of all patients who received an ICD in the University Medical Center Utrecht (UMCU) over the years 2006-2011...
June 2013: Netherlands Heart Journal
E H Lips, L Mulder, A Oonk, L E van der Kolk, F B L Hogervorst, A L T Imholz, J Wesseling, S Rodenhuis, P M Nederlof
BACKGROUND: BRCAness is defined as shared tumour characteristics between sporadic and BRCA-mutated cancers. However, how to exactly measure BRCAness and its frequency in breast cancer is not known. Assays to establish BRCAness would be extremely valuable for the clinical management of these tumours. We assessed BRCAness characteristics frequencies in a large cohort of triple-negative breast cancers (TNBCs). METHODS: As a measure of BRCAness, we determined a specific BRCA1-like pattern by array Comparative Genomic Hybridisation (aCGH), and BRCA1 promoter methylation in 377 TNBCs, obtained from 3 different patient cohorts...
May 28, 2013: British Journal of Cancer
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