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Michael G Tecce, Marten N Basta, Valeriy Shubinets, Michael A Lanni, Michael N Mirzabeigi, Laura Cooney, Suneeta Senapati, Ashley F Haggerty, Jason M Weissler, J Andres Hernandez, John P Fischer
BACKGROUND: Incisional hernia (IH) is a complication following open abdominal hysterectomy. This study addresses the incidence and health care cost of IH repair after open hysterectomy, and identify perioperative risk factors to create predictive risk models. METHODS: We conduct a retrospective review of patients who underwent open hysterectomy between 2005 and 2013 at the University of Pennsylvania. The primary outcome was post-hysterectomy IH. Univariate/multivariate cox proportional hazard analyses identified perioperative risk factors...
October 11, 2016: American Journal of Surgery
Andre Pennardt, Rich Kamin, Craig Llewellyn, Geoff Shapiro, Philip A Carmona, Richard B Schwartz
Tactical emergency medical support (TEMS) is a critical component of the out-of-hospital response to domestic high-threat incidents such as hostage scenarios, warrant service, active shooter or violent incidents, terrorist attacks, and other intentional mass casualty-producing acts. From its grass-roots inception in the form of medical support of select law enforcement special weapons and tactics (SWAT) units in the 1980s, the TEMS subspecialty of prehospital care has rapidly grown and evolved over the past 40 years...
2016: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Elissavet N Rousanoglou, Konstantinos Noutsos, Achilleas Pappas, Gregory Bogdanis, Georgios Vagenas, Ioannis A Bayios, Konstantinos D Boudolos
The fatiguing effect of long-distance running has been examined in the context of a variety of parameters. However, there is scarcity of data regarding its effect on the vertical jump mechanics. The purpose of this study was to investigate the alterations of countermovement jump (CMJ) mechanics after a half-marathon mountain race. Twenty-seven runners performed CMJs before the race (Pre), immediately after the race (Post 1) and five minutes after Post 1 (Post 2). Instantaneous and ensemble-average analysis focused on jump height and, the maximum peaks and time-to-maximum peaks of: Displacement, vertical force (Fz), anterior-posterior force (Fx), Velocity and Power, in the eccentric (tECC) and concentric (tCON) phase of the jump, respectively...
June 2016: Journal of Sports Science & Medicine
Venkateshwar Mutyam, Ming Du, Xiaojiao Xue, Kim M Keeling, E Lucile White, J Robert Bostwick, Lynn Rasmussen, Bo Liu, Marina Mazur, Jeong S Hong, Emily Falk Libby, Feng Liang, Haibo Shang, Martin Mense, Mark J Suto, David M Bedwell, Steven M Rowe
RATIONALE: Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis. A number of agents are known to suppress PTCs, but are poorly efficacious or toxic. OBJECTIVES: To determine whether there are clinically available agents that elicit translational readthrough and improve CFTR function sufficient to confer therapeutic benefit to CF patients with PTCs. METHODS: Two independent screens, firefly luciferase and CFTR-mediated transepithelial chloride conductance assay (TECC), were performed on a library of 1600 clinically approved compounds using fisher rat thyroid (FRT) cells stably transfected with stop codons...
April 22, 2016: American Journal of Respiratory and Critical Care Medicine
Aldo Giudice, Giovanni D'Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D'Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella
MicroRNAs are short (21-23 nucleotides), noncoding RNAs that typically silence posttranscriptional gene expression through interaction with target messenger RNAs. Currently, miRNAs have been identified in almost all studied multicellular eukaryotes in the plant and animal kingdoms. Additionally, recent studies reported that miRNAs can also be encoded by certain single-cell eukaryotes and by viruses. The vast majority of viral miRNAs are encoded by the herpesviruses family. These DNA viruses including Epstein-Barr virus encode their own miRNAs and/or manipulate the expression of cellular miRNAs to facilitate respective infection cycles...
2016: Oxidative Medicine and Cellular Longevity
Maurizio Montella, Giovanni D'Arena, Anna Crispo, Mario Capunzo, Flavia Nocerino, Maria Grimaldi, Antonio Barbieri, Anna Maria D'Ursi, Mario Felice Tecce, Alfonso Amore, Massimiliano Galdiero, Gennaro Ciliberto, Aldo Giudice
Infection with hepatitis B virus (HBV) is a major risk factor for hepatocellular carcinoma (HCC) in developed countries. Epidemiological reports indicate that the incidence of HBV-related HCC is higher in males and postmenopausal females than other females. Increasing evidence suggests that sex hormones such as androgens and estrogens play an important role in the progression of an HBV infection and in the development of HBV-related HCC. While androgen is supposed to stimulate the androgen signaling pathway and cooperate to the increased transcription and replication of HBV genes, estrogen may play a protecting role against the progression of HBV infections and in the development of HBV-related HCC through decreasing HBV RNA transcription and inflammatory cytokines levels...
2015: International Journal of Endocrinology
Tania Rescigno, Anna Capasso, Mario Felice Tecce
n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), abundant in fish, have been shown to affect development and progression of some types of cancer, including breast cancer. The aim of our study was to further analyze and clarify the effects of these nutrients on the molecular mechanisms underlying breast cancer. Following treatments with DHA we examined cell viability, death, cell cycle, and some molecular effects in breast cell lines with different transformation, phenotypic, and biochemical characteristics (MCF-10A, MCF-7, SK-BR-3, ZR-75-1)...
June 2016: Journal of Cellular Physiology
Andrew D Fisher, David W Callaway, Josh N Robertson, Shane A Hardwick, Joshua P Bobko, Russ S Kotwal
Active violent incidents are dynamic and challenging situations that can produce a significant amount of preventable deaths. Lessons learned from the military?s experience in Afghanistan and Iraq through the Committee on Tactical Combat Casualty Care and the 75th Ranger Regiment?s Ranger First Responder Program have helped create the Committee for Tactical Emergency Casualty Care (C-TECC) to address the uniqueness of similar wounding patterns and to end preventable deaths. We propose a whole-community approach to active violent incidents, using the C-TECC Trauma Chain of Survival and a tiered approach for training and responsibilities: the first care provider, nonmedical professional first responders, medical first responders, and physicians and trauma surgeons...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Lee E Palmer, Richard Maricle, Jo-Anne Brenner
BACKGROUND: Approximately 20% to 25% of trauma-related, prehospital fatalities in humans are due to preventable deaths. Data are lacking, however, on the nature and the prevalence of operational canine (OC) prehospital deaths. It is plausible that OCs engaged in high-threat operations are also at risk for suffering some type of preventable death. Tactical Combat Casualty Care has significantly reduced human fatality rates on the battlefield. Standardized guidelines specifically for prehospital trauma care have not been developed for the OC caregiver...
2015: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Sanja Mancevska, Jasmina Plincevic Pluncevic, Lidija Todorovska, Beti Dejanova, Joseph Tecce
No abstract text is available yet for this article.
October 2014: Iranian Journal of Public Health
Asa M Margolis, Nelson Tang, Matthew J Levy, David W Callaway
The 2014 midyear, full meeting of the Committee for Tactical Emergency Combat Care (C-TECC) was hosted by the Johns Hopkins University Center for Law Enforcement Medicine on June 9 and 10 in Baltimore, Maryland. As the C-TECC guidelines are increasingly recognized as the best-practice recommendations for civilian, high-threat, prehospital trauma response, a focused guidelines discussion occurred to develop best-practice recommendations for the management of open chest wounds, specifically regarding the application of vented and nonvented chest seals...
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
David W Callaway, Reed Smith, Geoff Shapiro, Sean McKay
No abstract text is available yet for this article.
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Mariella Caputo, Maria Caterina De Rosa, Tania Rescigno, Hylde Zirpoli, Antonio Vassallo, Nunziatina De Tommasi, Gaetano Torino, Mario Felice Tecce
Stearoyl-CoA desaturase 1 (SCD1) is the rate limiting enzyme in unsaturated fatty acid biosynthesis. This enzyme has an important role in the regulation of hepatic lipogenesis and lipid oxidation, and alterations in these pathways may lead to several diseases. We examined, in HepG2 cell cultures, the mechanism of SCD1 regulation considering the involvement of two transcription factors: liver X receptor alpha (LXRα) and sterol regulatory element-binding protein-1 (SREBP-1), also investigating the effect of dietary polyunsaturated fatty acids (PUFAs) on this process...
December 2014: Cell Biochemistry and Function
Richard Schwartz, Brooke Lerner, Craig Llwewllyn, Andre Pennardt, Ian Wedmore, David Callaway, John Wightman, Raymond Casillas, Alex Eastman, Kevin Gerold, Stephen Giebner, Robert Davidson, Richard Kamin, Gina Piazza, Glenn Bollard, Phillip Carmona, Ben Sonstrom, William Seifarth, Barbara Nicely, John Croushorn, Richard Carmona
INTRODUCTION: Tactical teams are at high risk of sustaining injuries. Caring for these casualties in the field involves unique requirements beyond what is provided by traditional civilian emergency medical services (EMS) systems. Despite this need, the training objectives and competencies are not uniformly agreed to or taught. METHODS: An expert panel was convened that included members from the Departments of Defense, Homeland Security, Justice, and Health and Human Services, as well as federal, state, and local law-enforcement officers who were recruited through requests to stakeholder agencies and open invitations to individuals involved in Tactical Emergency Medical Services (TEMS) or its oversight...
2014: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Aldo Giudice, Anna Crispo, Galdiero Massimiliano, Giovanni D'Arena, Mario Felice Tecce, Maria Grimaldi, Alfonso Amore, Emanuela Esposito, Maurizio Montella
The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the incidence and mortality of other common cancers have been declining. Risk factors for this malignant disease include cigarette smoking, family history of chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption and possibly Helicobacter pylori and hepatitis B virus infections. Metabolic diseases have become the leading cause of death in many countries...
March 2014: Journal of Gastrointestinal and Liver Diseases: JGLD
Raymond B Flannery, Grace Wyshak, Joseph J Tecce, Georgina J Flannery
Previous reviews of the literature from 1976 to 2000 documented two categories of assaultive psychiatric patients: (1) male patients with schizophrenic illness and histories of violence toward others and substance use disorder and (2) male/female patients with personality disorders and histories of violence toward others, personal victimization, and substance use. The present study reviewed the published findings on American assaultive patients from 2000 to 2012. The present findings partially supported the earlier findings in that patients with schizophrenic illness continued to present the greatest risk for assault...
September 2014: Psychiatric Quarterly
Raymond B Flannery, Grace Wyshak, Joseph J Tecce, Georgina J Flannery
In international reviews of psychiatric inpatient violence, one study of all types of patient violence found hostility, involuntary admission, and longer hospital stays associated with violence. A second study of comparison-group papers of patient assaults found younger males with schizophrenia, past violence, and substance abuse assaultive. The present review of raw assault data studies assessed characteristics of assaultive patients worldwide. It was hypothesized that patients with schizophrenia would present greatest assault risk...
September 2014: Psychiatric Quarterly
Joshua Bobko, Tristan T Lai, E Reed Smith, Geoffrey L Shapiro, R Todd Baldridge, David W Callaway
BACKGROUND: Active shooter events and active violent incidents are increasingly targeting civilians, placing children at heightened risk for complex and devastating trauma. The U.S. Department of Homeland Security has identified as a priority preparing domestic first responders to manage complex mass casualty incidents as a primary step in strengthening our medical system. Existing literature suggests that many prehospital providers are uncomfortable treating critically ill or injured pediatric patients and that there is a gap in the consistent provision of high-quality trauma care to these patients...
2013: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Mariella Caputo, Hylde Zirpoli, Maria Caterina De Rosa, Tania Rescigno, Francesco Chiadini, Antonio Scaglione, Claudia Stellato, Giorgio Giurato, Alessandro Weisz, Mario Felice Tecce, Bruno Bisceglia
We evaluated the effects, on cultured human SaOS-2 cells, of exposures to the low frequency (LF) electric signal (60 kHz sinusoidal wave, 24.5 V peak-to-peak voltage, amplitude modulated by a 12.5 Hz square wave, 50% duty cycle) from an apparatus of current clinical use in bone diseases requiring regenerating processes. Cells in flasks were exposed to a capacitively coupled electric field giving electric current density in the sample of 4 µA/cm(2). The whole expressed cellular mRNAs were systematically analyzed by "DNA microchips" technology to identify all individual species quantitatively affected by field exposure...
December 2014: Electromagnetic Biology and Medicine
Sameer Ahmed, Pamela Tecce Johnson, Elliot K Fishman, Stefan Loy Zimmerman
The population of adults with repaired tetralogy of Fallot (TOF) is growing, thanks to improvements in the surgical and medical management of this condition. Accordingly, late postrepair complications are important medical concerns in these individuals. Initial surgical repair of TOF typically occurs in infancy, consisting of patch repair of the ventricular septal defect (VSD) and relief of right ventricular outflow tract (RVOT) obstruction. Although patients may remain asymptomatic for several decades, the majority will have progressive pulmonic regurgitation that leads to right ventricular (RV) dilatation and functional deterioration...
July 2013: Radiographics: a Review Publication of the Radiological Society of North America, Inc
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