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https://www.readbyqxmd.com/read/29679367/a-systematic-review-of-the-quality-of-reporting-of-simulation-studies-about-methods-for-the-analysis-of-complex-longitudinal-patient-reported-outcomes-data
#1
REVIEW
Aynslie M Hinds, Tolulope T Sajobi, Véronique Sebille, Richard Sawatzky, Lisa M Lix
PURPOSE: This study describes the characteristics and quality of reporting for published computer simulation studies about statistical methods to analyze complex longitudinal (i.e., repeated measures) patient-reported outcomes (PROs); we included methods for longitudinal latent variable measurement and growth models and response shift. METHODS: Scopus, PsycINFO, PubMed, EMBASE, and Social Science Citation Index were searched for English-language studies published between 1999 and 2016 using selected keywords...
April 20, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29674877/a-new-species-of-knob-scaled-lizard-xenosauridae-xenosaurus-from-the-sierra-madre-oriental-of-puebla-mexico
#2
Adrián Nieto-Montes de Oca, Helder Sánchez-Vega, Itzel Durán-Fuentes
A new species of Xenosaurus in the X. tzacualtipantecus clade is described from the Sierra Madre Oriental of northern Puebla, Mexico. The new species differs from all of its congeners in possessing a unique combination of characters. The new species appears to be allopatric and fills in the geographic gap between the geographic distributions of X. tzacualtipantecus and the species in the newmanorum clade to the north and northwest and those of the species in the grandis and rackhami clades to the south and southeast...
2018: ZooKeys
https://www.readbyqxmd.com/read/29665614/vo2max-testing-in-trail-runners-is-there-a-specific-exercise-test-protocol
#3
Volker Scheer, Katharina Ramme, Claus Reinsberger, Hans-Christian Heitkamp
Trail running places specific physiological demands on the human body due to its uphill and downhill running sections. We developed and investigated a more sport-specific trail exercise test protocol (inclination and speed incremental protocol), and compared it to two standard exercise test protocols (horizontal step and ramp protocol) in thirteen highly trained trail runners (age 31±6 years, height 179±6.4 cm, weight 69.2±7.9 kg, BMI 21.6±2.1 kg/m2 ). The maximum oxygen uptake (VO2 max) measured during the trail test (62...
April 17, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29665386/enzymatically-crosslinked-and-mechanically-tunable-silk-fibroin-pullulan-hydrogels-for-mesenchymal-stem-cells-delivery
#4
Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu, Li Sun, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang, Cheng Chen
Hydrogels with good biocompatibility, proper degradation rates, and tissue-matched elasticity are widely used in tissue engineering, regenerative medicine, and drug delivery. In this study, enzymatically crosslinked biocompatible hydrogels were successfully developed using silk fibroin (SF) and pullulan (PL) under physiological conditions in the presence of both horseradish peroxidase (HRP) and hydrogen peroxide (H2 O2 ). A series of properties of the hydrogels including gelation time, equilibrium swelling, enzyme degradation, morphology, rheological property, and compression modulus of SF/PL hydrogels were studied by varying the concentration of PL...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29596347/health-impacts-and-economic-costs-of-air-pollution-in-the-metropolitan-area-of-skopje
#5
Gerardo Sanchez Martinez, Joseph V Spadaro, Dimitris Chapizanis, Vladimir Kendrovski, Mihail Kochubovski, Pierpaolo Mudu
BACKGROUND: Urban outdoor air pollution, especially particulate matter, remains a major environmental health problem in Skopje, the capital of the former Yugoslav Republic of Macedonia. Despite the documented high levels of pollution in the city, the published evidence on its health impacts is as yet scarce. METHODS: we obtained, cleaned, and validated Particulate Matter (PM) concentration data from five air quality monitoring stations in the Skopje metropolitan area, applied relevant concentration-response functions, and evaluated health impacts against two theoretical policy scenarios...
March 29, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29565272/nanosized-coo-loaded-on-copper-foam-for-high-performance-binder-free-lithium-ion-batteries
#6
Mingna Liao, Qilun Zhang, Fengling Tang, Zhiwei Xu, Xin Zhou, Youpeng Li, Yali Zhang, Chenghao Yang, Qiang Ru, Lingzhi Zhao
The synthesis of nanosized CoO anodes with unique morphologies via a hydrothermal method is investigated. By adjusting the pH values of reaction solutions, nanoflakes (CoO-NFs) and nanoflowers (CoO-FLs) are successfully located on copper foam. Compared with CoO-FLs, CoO-NFs as anodes for lithium ion batteries present ameliorated lithium storage properties, such as good rate capability, excellent cycling stability, and large CoO nanoflakes; CoO nanoflowers; anodes; binder free; lithium ion batteriesreversible capacity...
March 22, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29564926/acid-suppression-in-patients-treated-with-endoscopic-therapy-for-the-management-of-gastroesophageal-varices-a-systematic-review-and-meta-analysis
#7
Jia Zhu, Xingshun Qi, Haonan Yu, Chunping Su, Xiaozhong Guo
BACKGROUND AND AIM: Endoscopic therapy is the cornerstone choice for the management of varices and variceal hemorrhage. The aim of the present systematic review and meta-analysis was to evaluate the efficacy of acid suppression in patients treated with endoscopic therapy for gastroesophageal varices. METHODS: All eligible studies were searched via the PubMed, EMBASE, and Cochrane Library databases. Incidence of bleeding, mortality, ulcers, chest pain, and dysphagia after endoscopic therapy and length of stay were analyzed...
March 22, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29564214/use-of-ketamine-sedation-for-the-management-of-displaced-paediatric-forearm-fractures
#8
Anatole Vilhelm Wiik, Poonam Patel, Joanna Bovis, Adele Cowper, Philip Socrates Pastides, Alison Hulme, Stuart Evans, Charles Stewart
AIM: To determine if ketamine sedation is a safe and cost effective way of treating displaced paediatric radial and ulna fractures in the emergency department. METHODS: Following an agreed interdepartmental protocol, fractures of the radius and ulna (moderately to severely displaced) in children between the age of 2 and 16 years old, presenting within a specified 4 mo period, were manipulated in our paediatric emergency department. Verbal and written consent was obtained prior to procedural sedation to ensure parents were informed and satisfied to have ketamine...
March 18, 2018: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29550427/large-scale-preparation-of-sulfated-polysaccharides-with-anti-angionenic-and-anti-inflammatory-properties-from-antrodia-cinnamomia
#9
Jing-Jy Cheng, Chi-Hsein Chao, Mei-Kuang Lu
Sulfated polysaccharides (SPSs) were isolated from 0.5 mM potassium-sulfate fed Antrodia cinnamomea. We investigated the chemical properties and bio-activities of the five different fractions (SPS-K1, SPS-K2, SPS-K3, SPS-K4, and SPS-K5) with molecular weights ranging from 0.51 to 523.48 kDa. SPS-K3 was consisted mainly of glucose, galactose and sulfate in a molar ratio of 15:1:30 with Mn value of 6.82 kDa. It showed maximal inhibition of the tumor necrosis factor (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) on bacterial LPS-induced inflammation in RAW264...
March 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29541564/comparison-of-hospital-wide-code-rates-and-mortality-before-and-after-the-implementation-of-a-rapid-response-team
#10
Muhammad Yousaf, Sheher Bano, Muhammad Attaur-Rehman, Chaudhary Muhammad Junaid Nazar, Aayesha Qadeer, Salma Khudaidad, Syed Waqar Hussain
Objective To compare hospital-wide code rates and mortality before and after the implementation of a rapid response team (RRT). Study design A prospective cohort design with historical controls. Place of study This study was conducted at Shifa International Hospital, Islamabad, from January 21, 2016, to January 20, 2017. Materials and methods The triggers for the rapid response team (RRT) were displayed on each floor. The in-house staff was trained on when and how to activate the rapid response team (RRT). Data were collected on a specified data collection form...
January 9, 2018: Curēus
https://www.readbyqxmd.com/read/29534037/molecular-cloning-and-characterization-of-carbonic-anhydrase-xii-from-pufferfish-takifugu-rubripes
#11
Kanij Rukshana Sumi, Soo Cheol Kim, Jewel Howlader, Won Kyo Lee, Kap Seong Choi, Hoy-Taek Kim, Jong-In Park, Ill-Sup Nou, Kang Hee Kho
In this study, an 1888-bp carbonic anhydrase XII (CA XII) sequence was cloned from the brain of the pufferfish, Takifugu rubripes . The cloned sequence contained a coding region of 1470-bp, which was predicted to translate into a protein of 490 amino acid residues. The predicted protein showed between 68-56% identity with the large yellow croaker ( Larimichthys crocea ), tilapia ( Oreochromis niloticus ), and Asian arowana ( Scleropages formosus ) CA XII proteins. It also exhibited 36% and 53% identity with human CA II and CA XII, respectively...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29528908/closing-perianal-fistulas-using-a-laser-long-term-results-in-103-patients
#12
Mustafa Cem Terzi, Cihan Agalar, Sari Habip, Aras Emre Canda, Naciye Cigdem Arslan, Funda Obuz
BACKGROUND: Primary closure of the fistula tract using energy emitted by a radial fiber connected to a diode laser is a novel procedure for treating perianal fistulas. OBJECTIVE: The aim of this study was to determine the long-term effectiveness of this new technique. DESIGN: The surgical objective was to seal the fistula tract using laser energy. SETTINGS: The study was conducted at a single day-case surgery center...
March 8, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29487049/clinical-course-of-untreated-cervical-intraepithelial-neoplasia-grade-2-under-active-surveillance-systematic-review-and-meta-analysis
#13
REVIEW
Karoliina Tainio, Antonios Athanasiou, Kari A O Tikkinen, Riikka Aaltonen, Jovita Cárdenas, Hernándes, Sivan Glazer-Livson, Maija Jakobsson, Kirsi Joronen, Mari Kiviharju, Karolina Louvanto, Sanna Oksjoki, Riikka Tähtinen, Seppo Virtanen, Pekka Nieminen, Maria Kyrgiou, Ilkka Kalliala
OBJECTIVE: To estimate the regression, persistence, and progression of untreated cervical intraepithelial neoplasia grade 2 (CIN2) lesions managed conservatively as well as compliance with follow-up protocols. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) from 1 January 1973 to 20 August 2016. ELIGIBILITY CRITERIA: Studies reporting on outcomes of histologically confirmed CIN2 in non-pregnant women, managed conservatively for three or more months...
February 27, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29481423/diabetes-and-blood-glucose-disorders-under-anti-pd1
#14
Quentin Magis, Caroline Gaudy-Marqueste, Agnes Basire, Anderson Loundou, Nausicaa Malissen, Laura Troin, Sandrine Monestier, Stéphanie Mallet, Sylvie Hesse, Marie-Aleth Richard, René Valéro, Sophie Beliard, Jean-Jacques Grob
Acute type 1 diabetes (AD1) is a rare but definitive immune-related adverse event associated with anti-PD1. Most of the reported cases are close to what has been described as "fulminant type 1 diabetes." We sought to determine whether anti-PD1 could impair glycoregulation and whether occurrence of AD1 could be anticipated by prior glycemic changes. Fasting glycemia collected before, under, and after treatment in melanoma patients treated with anti-PD1 over a period of 36 months were retrospectively analyzed...
February 23, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29463125/salbutamol-in-acute-organophosphorus-insecticide-poisoning-a-pilotdose-response-phase-ii-study
#15
Fazle Rabbi Chowdhury, Md Mustafezur Rahman, Parash Ullah, Abdul Mumith Ruhan, Md Shafiqul Bari, M M Jahangir Alam, Md Moyeen Uddin, Shomik Maruf, Md Ismail Patwary, Michael Eddleston
BACKGROUND: Treatment of acute organophosphorus (OP) insecticide poisoning is difficult, with many patients dying despite best care. Pre-clinical studies have shown benefit from salbutamol, possibly due speeding alveolar fluid clearance or reducing bronchoconstriction. In this small pilot dose-response study, we aimed to explore whether addition of nebulized salbutamol to standard care might improve resuscitation. METHODS: We performed a single-blind phase II study comparing the effect of two different doses of nebulized salbutamol versus saline placebo, in addition to standard treatment...
February 20, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29434428/evaluation-of-endovenous-laser-ablation-for-varicose-veins-using-a-computer-simulation-model-secondary-publication
#16
REVIEW
Hisanao Hazama, Masato Yoshimori, Norihiro Honda, Kunio Awazu
Background and aims: Endovenous laser ablation (EVLA) has been well-reported as a minimally invasive method to deal with varices of the lower extremities. The lasers used fall into two categories: pigment, i.e., hemoglobin-specific lasers in the visible and near-infrared (near-IR) wavebands and longer wavelength mid-infrared lasers where the chromophore is water. The fiber used to deliver the laser energy is also important, and not enough attention has been paid to this element of EVLA...
December 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/29429602/-characteristics-and-health-status-of-homeless-women-born-in-france-and-abroad-results-of-insee-ined-2012-survey
#17
M-E Gomes do Espirito Santo, A-L Perrine, C Bonaldi, I Guseva-Canu
BACKGROUND: French national surveys among the homeless population in 2001 and 2012 provided a general description of the homeless beneficiaries of medical and social aids. However, given the increasing number of women in this population, mostly born abroad and accompanied by their children, a descriptive study of homeless women according to the fact of being born in France or abroad was conducted. METHODS: A probability sample of 1470 French-speaking homeless women was recruited for the Insee-Ined 2012 survey...
February 8, 2018: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29401783/design-of-a-compact-cmos-compatible-photonic-antenna-by-topological-optimization
#18
Julián L Pita, Ivan Aldaya, Paulo Dainese, Hugo E Hernandez-Figueroa, Lucas H Gabrielli
Photonic antennas are critical in applications such as spectroscopy, photovoltaics, optical communications, holography, and sensors. In most of those applications, metallic antennas have been employed due to their reduced sizes. Nevertheless, compact metallic antennas suffer from high dissipative loss, wavelength-dependent radiation pattern, and they are difficult to integrate with CMOS technology. All-dielectric antennas have been proposed to overcome those disadvantages because, in contrast to metallic ones, they are CMOS-compatible, easier to integrate with typical silicon waveguides, and they generally present a broader wavelength range of operation...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29390960/a-high-throughput-screen-for-active-human-transposable-elements
#19
Erika M Kvikstad, Paolo Piazza, Jenny C Taylor, Gerton Lunter
BACKGROUND: Transposable elements (TEs) are mobile genetic sequences that randomly propagate within their host's genome. This mobility has the potential to affect gene transcription and cause disease. However, TEs are technically challenging to identify, which complicates efforts to assess the impact of TE insertions on disease. Here we present a targeted sequencing protocol and computational pipeline to identify polymorphic and novel TE insertions using next-generation sequencing: TE-NGS...
February 1, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29388061/clinical-impact-of-pi3k-braf-mutations-in-ras-wild-metastatic-colorectal-cancer-meta-analysis-results
#20
Amr Mohamed, Brandon Twardy, Nadine AbdAllah, Alaa Akhras, Hibah Ismail, Magdi Zordok, Kelly Schrapp, Taraq Attumi, Anteneh Tesfaye, Bassel El-Rayes
BACKGROUND: Understanding the molecular mechanisms of colorectal cancer has evolved during the last decade ushering the era of personalized medicine. Alteration of BRAF and PI3K is common in colorectal cancer, and can affect several signaling pathways including EGFR (epidermal growth factor receptor). The aim of this meta-analysis is to evaluate the clinical role of PI3K and BRAF mutations in patients with KRAS wild-type metastatic colorectal cancer (MCRC) receiving an EGFR monoclonal antibody (anti-EGFR) inhibitor as first-line therapy...
February 1, 2018: Journal of Gastrointestinal Cancer
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