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https://www.readbyqxmd.com/read/28317556/skull-5-from-dmanisi-descriptive-anatomy-comparative-studies-and-evolutionary-significance
#1
G Philip Rightmire, Marcia S Ponce de León, David Lordkipanidze, Ann Margvelashvili, Christoph P E Zollikofer
A fifth hominin skull (cranium D4500 and mandible D2600) from Dmanisi is massively constructed, with a large face and a very small brain. Traits documented for the first time in a basal member of the Homo clade include the uniquely low ratio of endocranial volume to basicranial width, reduced vertex height, angular vault profile, smooth nasal sill coupled with a long and sloping maxillary clivus, elongated palate, and tall mandibular corpus. The convex clivus and receding symphysis of skull 5 produce a muzzle-like form similar to that of Australopithecus afarensis...
March 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28299832/secular-and-longitudinal-physical-activity-changes-in-population-based-samples-of-children-and-adolescents
#2
Knut Eirik Dalene, Sigmund A Anderssen, Lars Bo Andersen, Jostein Steene-Johannessen, Ulf Ekelund, Bjørge H Hansen, Elin Kolle
PURPOSE: 1) To investigate if physical activity (PA) and sedentary time (ST) in 9- and 15-year-olds differed between 2005-06 and 2011-12 (secular change) and: 2) to investigate changes in PA and ST from age 9 to 15 (longitudinal change). METHODS: In 2005-06, we invited nationally representative samples of Norwegian 9- (n=1470) and 15-year-olds (n=1348) to participate. In 2011-12, we invited a new nationally representative sample of 9-year-olds (n=1945), whereas 15-year-olds (n=1759) were invited to participate either based on previous participation in 2005-06 or from a random sample of schools...
March 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28274930/nitric-oxide-reduces-paracellular-resistance-in-rat-thick-ascending-limbs-by-increasing-na-and-cl-permeabilities
#3
Casandra Margarita Monzon, Rossana Occhipinti, Omar Pedro Pignataro, Jeffrey L Garvin
About 50% of the Na+ reabsorbed in thick ascending limbs traverses the paracellular pathway. Nitric oxide (NO) reduces the permselectivity of this pathway via cGMP, but its effects on absolute Na(+) (PNa(+)) and Cl(-) (PCl(-)) permeabilities are unknown. To address this, we measured the effect L-arginine (0.5mmol/L; NO synthase substrate) and cGMP (0.5mmol/L) on PNa(+) and PCl(-) calculated from transepithelial resistance (Rt) and PNa(+)/PCl(-) Rt was 7722±1554 ohm-cm in the control period and 6318±1757 ohm-cm after L-arginine treatment (p<0...
March 8, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28267226/analyzing-symptom-data-in-indoor-air-questionnaires-for-primary-schools
#4
Sari Ung-Lanki, Jussi Lampi, Juha Pekkanen
Questionnaires on symptoms and perceived quality of indoor environment are used to assess indoor environment problems, but mainly among adults. The aim of this article is to explore best ways to analyze and report such symptom data, as part of a project to develop a parent-administered indoor air questionnaire for primary school pupils. Indoor air questionnaire with 25 questions on child's symptoms in the last 4 weeks was sent to parents in 5 primary schools with indoor air problems and in 5 control schools...
March 7, 2017: Indoor Air
https://www.readbyqxmd.com/read/28258659/genome-wide-survey-of-nuclear-protein-coding-markers-for-beetle-phylogenetics-and-their-application-in-resolving-both-deep-and-shallow-level-divergences
#5
Li-Heng Che, Shao-Qian Zhang, Yun Li, Dan Liang, Hong Pang, Adam Ślipiński, Peng Zhang
Beetles (Coleoptera) are the most diverse and species-rich insect group, representing an impressive explosive radiation in the evolutionary history of insects, and their evolutionary relationships are often difficult to resolve. The amount of "traditional markers" (e.g., mitochondrial genes and nuclear rDNAs) for beetle phylogenetics is small and these markers often lack sufficient signals in resolving relationships for such a rapidly radiating lineage. Here, based on the available genome data of beetles and other related insect species, we performed a genome-wide survey to search nuclear protein-coding (NPC) genes suitable for research on beetle phylogenetics...
March 3, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28254720/organic-contaminants-and-heavy-metals-in-indoor-dust-from-e-waste-recycling-rural-and-urban-areas-in-south-china-spatial-characteristics-and-implications-for-human-exposure
#6
Chun-Tao He, Xiao-Bo Zheng, Xiao Yan, Jing Zheng, Mei-Huan Wang, Xiao Tan, Lin Qiao, She-Jun Chen, Zhong-Yi Yang, Bi-Xian Mai
The concentrations of several organic contaminants (OCs) and heavy metals were measured in indoor dust from e-waste recycling, rural, and urban areas in South China to illustrate the spatial characteristics of these pollutants and to further evaluate human exposure risks. The median concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), decabromodiphenyl ethane (DBDPE), and dechlorane plus (DPs) were 38.6-3560, 2360-30,100, 665-2720, and 19.5-1860ng/g, while the median concentrations of Cd, Pb, Cu, Cr, and Zn were 2...
February 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28251619/narcolepsy-patients-blood-based-mirna-expression-profiling-mirna-expression-differences%C3%A2-with-pandemrix-vaccination
#7
N Mosakhani, V Sarhadi, P Panula, M Partinen, S Knuutila
OBJECTIVES: Narcolepsy is a neurological sleep disorder characterized by excessive daytime sleepiness and nighttime sleep disturbance. Among children and adolescents vaccinated with Pandemrix vaccine in Finland and Sweden, the number of narcolepsy cases increased. Our aim was to identify miRNAs involved in narcolepsy and their association with Pandemrix vaccination. MATERIALS AND METHODS: We performed global miRNA proofing by miRNA microarrays followed by RT-PCR verification on 20 narcolepsy patients (Pandemrix-associated and Pandemrix-non-associated) and 17 controls (vaccinated and non-vaccinated)...
March 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28239223/exercise-reduces-depressive-symptoms-in-adults-with-arthritis-evidential-value
#8
George A Kelley, Kristi S Kelley
PURPOSE: Determine whether evidential value exists that exercise reduces depressive symptoms in adults with arthritis and other rheumatic diseases. METHODS: Using data from a previous meta-analysis of 29 published studies that included 2449 participants (1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a novel, recently developed method, p-curve, was used to assess for evidential value and rule out selective reporting of statistically significant findings regarding exercise and depressive symptoms in adults with arthritis and other rheumatic diseases...
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28238947/identification-of-novel-mrp3-inhibitors-based-on-computational-models-and-validation-using-an-in-vitro-membrane-vesicle-assay
#9
Izna Ali, Matthew A Welch, Yang Lu, Peter W Swaan, Kim L R Brouwer
INTRODUCTION: Multidrug resistance-associated protein 3 (MRP3), an efflux transporter on the hepatic basolateral membrane, may function as a compensatory mechanism to prevent the accumulation of anionic substrates (e.g., bile acids) in hepatocytes. Inhibition of MRP3 may disrupt bile acid homeostasis and is one hypothesized risk factor for the development of drug-induced liver injury (DILI). Therefore, identifying potential MRP3 inhibitors could help mitigate the occurrence of DILI. METHODS: Bayesian models were developed using MRP3 transporter inhibition data for 86 structurally diverse drugs...
February 24, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28228566/reduced-cognitive-function-in-patients-with-parkinson-disease-and-obstructive-sleep-apnea
#10
Victoria P Mery, Priti Gros, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, R John Kimoff, Marta Kaminska
OBJECTIVE: To assess the association between obstructive sleep apnea (OSA) and nonmotor symptoms (NMS), including cognitive dysfunction, in patients with Parkinson disease (PD). METHODS: Patients with idiopathic PD, recruited from a movement disorder clinic, underwent overnight polysomnography. OSA was defined as an apnea-hypopnea index (AHI) ≥15/h. PD severity was assessed using the Hoehn & Yahr (H&Y) scale and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS)...
February 22, 2017: Neurology
https://www.readbyqxmd.com/read/28226187/systematic-review-of-treatments-for-diabetic-peripheral-neuropathy-lost-in-translation
#11
I A Volchegorskii
We read with great interest the systematic review by Çakici et al. [1] on treatments for diabetic peripheral neuropathy. Unfortunately, on careful reading, we found a number of inaccuracies and factual errors. First, we were rather surprised that there was almost no mention of mexidol, although a conclusion about its effectiveness in treating diabetic peripheral neuropathy is in the 'What's new?' section, as well as in the final sentence of the main text under the 'Strengths and limitations' section and in the abstract...
February 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28225639/cost-effectiveness-comparison-of-imaging-guided-prostate-biopsy-techniques-systematic-transrectal-ultrasound-direct-in-bore-mri-and-image-fusion
#12
Wulphert Venderink, Tim M Govers, Maarten de Rooij, Jurgen J Fütterer, J P Michiel Sedelaar
OBJECTIVE: Three commonly used prostate biopsy approaches are systematic transrectal ultrasound guided, direct in-bore MRI guided, and image fusion guided. The aim of this study was to calculate which strategy is most cost-effective. MATERIALS AND METHODS: A decision tree and Markov model were developed to compare cost-effectiveness. Literature review and expert opinion were used as input. A strategy was deemed cost-effective if the costs of gaining one quality-adjusted life year (incremental cost-effectiveness ratio) did not exceed the willingness-to-pay threshold of €80,000 (≈$85,000 in January 2017)...
February 22, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28184992/association-study-between-the-tp53-rs1042522g-c-polymorphism-and-susceptibility-to-systemic-lupus-erythematosus-in-a-chinese-han-population
#13
Jie Yang, Ji-Min Zhu, Song Wu, Jing Li, Ming-Rui Wang, Ting-Ting Wang, Yu-Wei Lu
Tumour suppressor protein 53 (p53) plays a central role in apoptosis, cell proliferation and death. Previously studies found contribution of functional p53 Arg72Pro polymorphism (TP53 rs1042522G/C polymorphism) in the development of systemic lupus erythematosus (SLE) remains controversial. In this study, for the first time, we evaluated its association with SLE in a Chinese Han population. This case-control study enrolled 1470 SLE patients and 2283 healthy controls. The genotyping of TP53 rs1042522 polymorphism was determined by Sequenom Mass ARRAY technology...
February 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28160334/influence-of-sumac-rhus-coriaria-l-and-ginger-zingiber-officinale-on-egg-yolk-fatty-acid-cholesterol-and-blood-parameters-in-laying-hens
#14
Y Gurbuz, Y G Salih
The aim of the study was to evaluate the potential effect of different levels of sumac (Rhus coriaria L.) seed powder and ginger (Zingiber officinale) root powder on egg yolk fatty acid composition, blood/yolk cholesterol in laying hen. A total of 63 (ATAK-S: Domestic Turkish Laying Hens) laying hens (average weight: 1470 g each hen, 25-weeks of age) were assigned to seven treatment diets including sumac seed (S) and ginger root powder (G) at 0 g/kg (control), 10 g/kg (S1), 20 g/kg (S2), and 30 g/kg (S3); 10 g/kg (G1), 20 g/kg (G2), or 30 g/kg in rations respectively, for 8 weeks...
February 4, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28134021/endovenous-laser-treatment-of-groin-and-popliteal-varicose-veins-recurrence
#15
Alvise Cavallini, Daniela Marcer, Salvatore Ferrari Ruffino
Objectives Recurrent varicose veins following surgery is a common, complex and costly problem in vascular surgery. Treatment for RVV is technically more difficult to perform and patient satisfaction is poorer than after primary interventions. Nevertheless, traditional vein surgery has largely been replaced by percutaneous office-based procedures, and the patients with recurrent varicose veins have not benefited from the same advantages. In this paper, we propose an endovascular laser treatment that allows reducing the invasiveness and complications in case of SFJ and SPJ reflux after ligation and stripping of the great and small saphenous vein...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28121192/integrating-patients-perceptions-into-clinical-practice-guidelines-for-the-management-of-rheumatoid-arthritis-in-japan
#16
Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka
OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified...
January 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28116687/larval-outbreaks-in-west-greenland-instant-and-subsequent-effects-on-tundra-ecosystem-productivity-and-co2-exchange
#17
Magnus Lund, Katrine Raundrup, Andreas Westergaard-Nielsen, Efrén López-Blanco, Josephine Nymand, Peter Aastrup
Insect outbreaks can have important consequences for tundra ecosystems. In this study, we synthesise available information on outbreaks of larvae of the noctuid moth Eurois occulta in Greenland. Based on an extensive dataset from a monitoring programme in Kobbefjord, West Greenland, we demonstrate effects of a larval outbreak in 2011 on vegetation productivity and CO2 exchange. We estimate a decreased carbon (C) sink strength in the order of 118-143 g C m(-2), corresponding to 1210-1470 tonnes C at the Kobbefjord catchment scale...
February 2017: Ambio
https://www.readbyqxmd.com/read/28087133/secukinumab-sustains-early-patient-reported-outcome-benefits-through-1%C3%A2-year-results-from-2-phase-iii-randomized-placebo-controlled-clinical-trials-comparing-secukinumab-with-etanercept
#18
Bruce Strober, Alice B Gottlieb, Bintu Sherif, Patrick Mollon, Isabelle Gilloteau, Lori McLeod, Todd Fox, Margaret Mordin, Ari Gnanasakthy, Charis Papavassilis, Mark G Lebwohl
BACKGROUND: Psoriasis is a chronic condition with negative impact on patients' quality of life that most often requires lifelong effective and safe treatment. OBJECTIVE: This analysis focused on the effect of secukinumab treatment on patient-reported health-related quality of life as assessed by the Dermatology Life Quality Index (DLQI) in patients with moderate to severe psoriasis. METHODS: The proportion of subjects achieving DLQI score 0/1 response at week 24, time to DLQI score 0/1 response, and sustained DLQI score 0/1 response up to week 52 were compared between secukinumab and etanercept...
January 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28027669/the-vertebroplacental-ratio-as-an-alternative-to-the-cerebroplacental-ratio-in-the-evaluation-of-the-fetus-at-the-end-of-pregnancy
#19
José Morales-Roselló, Asma Khalil, Victoria Fornés-Ferrer, David Hervas-Marín, Nuria Peralta-Llorens, Juan Rubio-Moll, Alfredo Perales-Marín
OBJECTIVE: Low cerebroplacental ratio (CPR) near term has emerged as a marker of fetal adverse outcome. The aim of this study was to evaluate the predictive accuracy of an alternative ratio using the vertebral artery (VA) (vertebroplacental ratio or VPR) for acid-base status at birth. METHODS: This was a prospective cohort study of 1470 pregnancies undergoing an ultrasound assessment of the umbilical artery, middle cerebral artery and VA Doppler beyond 34 weeks' gestation within 14 days of delivery...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28018497/morphological-comparison-of-blood-vessels-that-were-heated-with-a-radiofrequency-device-or-a-1470-nm-laser-and-a-radial-2ring-fiber
#20
Takashi Yamamoto, Masahiro Sakata
Introduction: Radio waves and lasers can be used as heat sources during endovenous thermal ablation (EVTA) for saphenous vein insufficiency. A morphological comparison of veins that had been treated with EVTA was performed between those treated with an endovenous closure system (a radiofrequency [RF] system) and those treated with a Radial 2Ring fiber connected to a 1470-nm laser generator (2R). Methods: The experiment was conducted in a system that reproduces the physiological conditions found in the saphenous veins during EVTA...
2016: Annals of Vascular Diseases
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