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Alkiviades F Pappas, Dimitrios K Christodoulou
BACKGROUND: Various surgical techniques are available for the management of pilonidal sinus, but there is still controversy concerning the optimal surgical approach. The aim of our study was to evaluate the safety, efficacy and clinical outcome of the laser procedure for the treatment of pilonidal sinus. PATIENTS - METHODS: Patients suffering from pilonidal sinus were operated with Sinus Laser Therapy (SiLaT) in our Institute. SiLaT was applied under local anaesthesia after a small skin incision of 0...
June 7, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Ling Li, Shuang Fang Lim, Alexander Puretzky, Robert Riehn, Hans D Hallen
We show that DNA carrying 5-methylcytosine modifications or methylated DNA (m-DNA) can be distinguished from DNA with unmodified cytosine by Raman spectroscopy enhanced by both a bowtie nanoantenna and excitation resonance. In particular, m-DNA can be identified by a peak near 1000 cm-1 and changes in the Raman peaks in the 1200-1700 cm-1 band that are enhanced by the ring-absorption resonance. The identification is robust to the use of resonance Raman and nanoantenna excitation used to obtain significant signal improvement...
June 5, 2018: Biophysical Journal
Holger J Sørensen, Jean-Christophe Debost, Esben Agerbo, Michael E Benros, John J McGrath, Preben Bo Mortensen, Anne Ranning, Carsten Hjorthøj, Ole Mors, Merete Nordentoft, Liselotte Petersen
BACKGROUND: Studies have suggested that poor school achievement is associated with increased risk of schizophrenia; however, the possible genetic contribution to this association is unknown. We investigated the possible effect of the polygenic risk score (PRS) for schizophrenia (PRSSCZ ) and for educational attainment (PRSEDU ) on the association between school performance and later schizophrenia. METHODS: We conducted a case-cohort study on a Danish population-based sample born from 1987 to 1995 comprising 1470 individuals with schizophrenia and 7318 subcohort noncases...
May 3, 2018: Biological Psychiatry
Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen, Lihua Sun
BACKGROUND: Oral progestin has recently been used to prevent premature LH surges in ovarian stimulation, and this progestin-primed ovarian stimulation (PPOS) is effective and safe in patients with different ovarian reserves. The current data are lacking regarding how to individualize the gonadotropin dose and regimen for women with polycystic ovarian syndrome (PCOS). A retrospective cohort trial was performed to evaluate the efficacy of progestin-primed milder stimulation with clomiphene citrate (CC) compared to the standard progestin-primed ovarian stimulation (PPOS) protocol for infertile women with PCOS...
May 28, 2018: Reproductive Biology and Endocrinology: RB&E
Walter Junior Boim de Araujo, Jorge Rufino Ribas Timi, Luiz Roberto Kotze, Cleber Rafael Vieira da Costa
Objectives To evaluate histological and immunohistochemical changes in the great saphenous vein after endovenous laser ablation at two different wavelengths (1470 vs. 1940 nm) and linear endovenous energy density values (50 vs. 100 J/cm). Method Segments were obtained from the conventional eversion removal of great saphenous vein and divided into a control group and four groups for ex vivo irradiation (control group; A: 1470 nm, 50 J/cm; B: 1470 nm, 100 J/cm; C: 1940 nm, 50 J/cm; D: 1940 nm, 100 J/cm)...
January 1, 2018: Phlebology
Wei Xu, Yu-Lin Chen, Ying Zhao, Li-Jie Wang, Jiu-Jun Li, Chun-Feng Liu
Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000 mg (800-5,000). Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents...
2018: BioMed Research International
Ariana Lott, Jack Haglin, Hesham Saleh, Jordan Hall, Kenneth A Egol, Sanjit R Konda
OBJECTIVES: 1) Demonstrate that a validated trauma triage score for middle-aged and geriatric patients could identify those at high risk for mortality within the first two days of hospitalization and 2) determine the cost of care for this cohort of patients DESIGN:: Prospective cohort study SETTING:: Single Level 1 Trauma Center PATIENTS:: Patients 55 years and older who were evaluated in the emergency department setting by Orthopaedics or who met American College of Surgeons Tier 1-3 criteria INTERVENTION:: Calculation of validated trauma triage score, Score for Trauma Triage in Geriatric and Middle Aged (STTGMA), using patient's demographic, injury severity, and functional statusMain Outcome Measurements: length of stay, inpatient mortality, time between presentation and time of death, and direct variable costs of hospitalization RESULTS:: A total of 1470 consecutive patients (mean age of 72...
May 3, 2018: Journal of Orthopaedic Trauma
Tiantian Shi, Duo Pan, Pengyuan Chang, Haosen Shang, Jingbiao Chen
Without exploiting any frequency selective elements, we have realized a highly integrated, single-mode, narrow-linewidth Nd:YAG 1064 nm laser, which is end-pumped by the 808.6 nm diode laser in an integrated invar cavity. It turns out that each 1064 nm laser achieves a most probable linewidth of 8.5 kHz by beating between two identical laser systems. The output power of the 1064 nm laser increases steadily as the 808.6 nm pump power is raised, which can be up to 350 mW. Moreover, the resonant wavelength of cavity grows continuously in a certain crystal temperature range...
April 2018: Review of Scientific Instruments
Duo Pan, Tiantian Shi, Bin Luo, Jingbiao Chen, Hong Guo
Taking advantages of ultra-narrow bandwidth and high noise rejection performance of the Faraday anomalous dispersion optical filter (FADOF), simultaneously with the coherent amplification of atomic stimulated emission, we propose a stimulated amplified Faraday anomalous dispersion optical filter (SAFADOF) at cesium 1470 nm. The SAFADOF is able to significantly amplify very weak laser signals and reject noise in order to obtain clean signals in strong background. We show that for a weak signal of 50 pW, the gain factor can be larger than 25000 (44 dB) within a bandwidth as narrow as 13 MHz...
April 26, 2018: Scientific Reports
Nikolai Yunakov, Vitalij Nazarenko, Rostislav Filimonov, Semyon Volovnik
The fauna of weevils Curculionoidea of Ukraine numbers 1453 species equivalent to 25.3% of European fauna. They belong to 10 families and 364 genera. A total of 51 species are recorded from Ukraine for the first time. Assessment of inventory completeness indicates that 62% of the area of Ukraine are covered by samples. Spatial join analysis has reveals strong collecting biases and shows maximal richness in cells which fall into well-sampled provinces. A total of 22 out of 33 studied model sites are well-sampled (C>0...
April 5, 2018: Zootaxa
Xing Zhang, Xin Wang, Cheng Gao, Jinbao Qin, Haiguang Zhao, Weimin Li, Xinwu Lu
Day surgery is being more and more adopted by clinicians. Higher wavelength lasers give patients better experience than lower wavelength lasers, which makes it more suitable for day surgery. This study compares the short- and mid-term efficacy, postoperative morbidity, and patient satisfaction of "1470-nm endovenous laser ablation (EVLA) combining foam sclerotherapy in day surgery" with "810-nm EVLA with high ligation combining foam sclerotherapy in hospital surgery" on great saphenous vein (GSV) insufficiency postoperatively...
April 23, 2018: Lasers in Medical Science
Aynslie M Hinds, Tolulope T Sajobi, Véronique Sebille, Richard Sawatzky, Lisa M Lix
PURPOSE: This study describes the characteristics and quality of reporting for published computer simulation studies about statistical methods to analyze complex longitudinal (i.e., repeated measures) patient-reported outcomes (PROs); we included methods for longitudinal latent variable measurement and growth models and response shift. METHODS: Scopus, PsycINFO, PubMed, EMBASE, and Social Science Citation Index were searched for English-language studies published between 1999 and 2016 using selected keywords...
April 20, 2018: Quality of Life Research
Adrián Nieto-Montes de Oca, Helder Sánchez-Vega, Itzel Durán-Fuentes
A new species of Xenosaurus in the X. tzacualtipantecus clade is described from the Sierra Madre Oriental of northern Puebla, Mexico. The new species differs from all of its congeners in possessing a unique combination of characters. The new species appears to be allopatric and fills in the geographic gap between the geographic distributions of X. tzacualtipantecus and the species in the newmanorum clade to the north and northwest and those of the species in the grandis and rackhami clades to the south and southeast...
2018: ZooKeys
Volker Scheer, Katharina Ramme, Claus Reinsberger, Hans-Christian Heitkamp
Trail running places specific physiological demands on the human body due to its uphill and downhill running sections. We developed and investigated a more sport-specific trail exercise test protocol (inclination and speed incremental protocol), and compared it to two standard exercise test protocols (horizontal step and ramp protocol) in thirteen highly trained trail runners (age 31±6 years, height 179±6.4 cm, weight 69.2±7.9 kg, BMI 21.6±2.1 kg/m2 ). The maximum oxygen uptake (VO2 max) measured during the trail test (62...
June 2018: International Journal of Sports Medicine
Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu, Li Sun, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang, Cheng Chen
Hydrogels with good biocompatibility, proper degradation rates, and tissue-matched elasticity are widely used in tissue engineering, regenerative medicine, and drug delivery. In this study, enzymatically crosslinked biocompatible hydrogels were successfully developed using silk fibroin (SF) and pullulan (PL) under physiological conditions in the presence of both horseradish peroxidase and hydrogen peroxide. A series of properties of the hydrogels including gelation time, equilibrium swelling, enzyme degradation, morphology, rheological property, and compression modulus of SF/PL hydrogels were studied by varying the concentration of PL...
April 14, 2018: International Journal of Biological Macromolecules
Gerardo Sanchez Martinez, Joseph V Spadaro, Dimitris Chapizanis, Vladimir Kendrovski, Mihail Kochubovski, Pierpaolo Mudu
BACKGROUND: Urban outdoor air pollution, especially particulate matter, remains a major environmental health problem in Skopje, the capital of the former Yugoslav Republic of Macedonia. Despite the documented high levels of pollution in the city, the published evidence on its health impacts is as yet scarce. METHODS: we obtained, cleaned, and validated Particulate Matter (PM) concentration data from five air quality monitoring stations in the Skopje metropolitan area, applied relevant concentration-response functions, and evaluated health impacts against two theoretical policy scenarios...
March 29, 2018: International Journal of Environmental Research and Public Health
Mingna Liao, Qilun Zhang, Fengling Tang, Zhiwei Xu, Xin Zhou, Youpeng Li, Yali Zhang, Chenghao Yang, Qiang Ru, Lingzhi Zhao
The synthesis of nanosized CoO anodes with unique morphologies via a hydrothermal method is investigated. By adjusting the pH values of reaction solutions, nanoflakes (CoO-NFs) and nanoflowers (CoO-FLs) are successfully located on copper foam. Compared with CoO-FLs, CoO-NFs as anodes for lithium ion batteries present ameliorated lithium storage properties, such as good rate capability, excellent cycling stability, and large CoO nanoflakes; CoO nanoflowers; anodes; binder free; lithium ion batteriesreversible capacity...
March 22, 2018: Nanomaterials
Jia Zhu, Xingshun Qi, Haonan Yu, Chunping Su, Xiaozhong Guo
BACKGROUND AND AIM: Endoscopic therapy is the cornerstone choice for the management of varices and variceal hemorrhage. The aim of the present systematic review and meta-analysis was to evaluate the efficacy of acid suppression in patients treated with endoscopic therapy for gastroesophageal varices. METHODS: All eligible studies were searched via the PubMed, EMBASE, and Cochrane Library databases. Incidence of bleeding, mortality, ulcers, chest pain, and dysphagia after endoscopic therapy and length of stay were analyzed...
April 4, 2018: Expert Review of Gastroenterology & Hepatology
Anatole Vilhelm Wiik, Poonam Patel, Joanna Bovis, Adele Cowper, Philip Socrates Pastides, Alison Hulme, Stuart Evans, Charles Stewart
AIM: To determine if ketamine sedation is a safe and cost effective way of treating displaced paediatric radial and ulna fractures in the emergency department. METHODS: Following an agreed interdepartmental protocol, fractures of the radius and ulna (moderately to severely displaced) in children between the age of 2 and 16 years old, presenting within a specified 4 mo period, were manipulated in our paediatric emergency department. Verbal and written consent was obtained prior to procedural sedation to ensure parents were informed and satisfied to have ketamine...
March 18, 2018: World Journal of Orthopedics
Jing-Jy Cheng, Chi-Hsein Chao, Mei-Kuang Lu
Sulfated polysaccharides (SPSs) were isolated from 0.5mM potassium-sulfate fed Antrodia cinnamomea. We investigated the chemical properties and bio-activities of the five different fractions (SPS-K1, SPS-K2, SPS-K3, SPS-K4, and SPS-K5) with molecular weights ranging from 0.51 to 523.48kDa. SPS-K3 was consisted mainly of glucose, galactose and sulfate in a molar ratio of 15:1:30 with Mn value of 6.82kDa. It showed maximal inhibition of the tumor necrosis factor (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6) on bacterial LPS-induced inflammation in RAW264...
July 1, 2018: International Journal of Biological Macromolecules
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