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https://www.readbyqxmd.com/read/28087133/secukinumab-sustains-early-patient-reported-outcome-benefits-through-1%C3%A2-year-results-from-2-phase-iii-randomized-placebo-controlled-clinical-trials-comparing-secukinumab-with-etanercept
#1
Bruce Strober, Alice B Gottlieb, Bintu Sherif, Patrick Mollon, Isabelle Gilloteau, Lori McLeod, Todd Fox, Margaret Mordin, Ari Gnanasakthy, Charis Papavassilis, Mark G Lebwohl
BACKGROUND: Psoriasis is a chronic condition with negative impact on patients' quality of life that most often requires lifelong effective and safe treatment. OBJECTIVE: This analysis focused on the effect of secukinumab treatment on patient-reported health-related quality of life as assessed by the Dermatology Life Quality Index (DLQI) in patients with moderate to severe psoriasis. METHODS: The proportion of subjects achieving DLQI score 0/1 response at week 24, time to DLQI score 0/1 response, and sustained DLQI score 0/1 response up to week 52 were compared between secukinumab and etanercept...
January 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28027669/the-vertebroplacental-ratio-as-an-alternative-to-the-cerebroplacental-ratio-in-the-evaluation-of-the-fetus-at-the-end-of-pregnancy
#2
José Morales-Roselló, Asma Khalil, Victoria Fornes Ferrer, David Hervas-Marín, Nuria Peralta Llorens, Juan Rubio Moll, Alfredo Perales-Marín
OBJECTIVE: Low cerebroplacental ratio (CPR) near term has emerged as a marker of fetal adverse outcome. The aim of this study was to evaluate the predictive accuracy of an alternative ratio using the vertebral artery (vertebroplacental ratio or VPR) for acid-base status at birth. METHODS: This was a prospective cohort study of 1470 pregnancies undergoing an ultrasound assessment of the umbilical artery, middle cerebral artery and vertebral artery Doppler beyond 34 weeks' gestation within 14 days of delivery...
December 27, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28018497/morphological-comparison-of-blood-vessels-that-were-heated-with-a-radiofrequency-device-or-a-1470-nm-laser-and-a-radial-2ring-fiber
#3
Takashi Yamamoto, Masahiro Sakata
Introduction: Radio waves and lasers can be used as heat sources during endovenous thermal ablation (EVTA) for saphenous vein insufficiency. A morphological comparison of veins that had been treated with EVTA was performed between those treated with an endovenous closure system (a radiofrequency [RF] system) and those treated with a Radial 2Ring fiber connected to a 1470-nm laser generator (2R). Methods: The experiment was conducted in a system that reproduces the physiological conditions found in the saphenous veins during EVTA...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/28018495/postoperative-venous-thromboembolism-in-patients-undergoing-endovenous-laser-and-radiofrequency-ablation-of-the-saphenous-vein
#4
Nobuhisa Kurihara, Masayuki Hirokawa, Takashi Yamamoto
Objective: Endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) are safe and effective treatments for varicose veins caused by saphenous reflux. Deep venous thrombosis (DVT) and endovenous heat-induced thrombosis (EHIT) are known complications of these procedures. The purpose of this article is to investigate the incidence of postoperative DVT and EHIT in patients undergoing EVLA and RFA. Methods: The patients were assessed by clinical examination and venous duplex ultrasonography before operation and at 24-72 hours, 1 month, and 1 year follow-up after operation...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27990230/in-vivo-photonic-stimulation-of-sciatic-nerve-with-a-1470-nm-laser
#5
Marie Dautrebande, Pascal Doguet, Simon-Pierre Gorza, Jean Delbeke, Yohan Botquin, Antoine Nonclercq
Photonic stimulation is a new modality of nerve stimulation, which could overcome some of the electrical stimulation limitations. In this paper, we present the results of photonic stimulation of rodent sciatic nerve with a 1470 nm laser. Muscle activation was observed with radiant exposure of 0.084 J/cm².
June 13, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/27986373/school-experiences-of-siblings-of-children-with-chronic-illness-a-systematic-literature-review
#6
REVIEW
Lucy L Gan, Alistair Lum, Claire E Wakefield, Beeshman Nandakumar, Joanna E Fardell
PROBLEM: Siblings of children with chronic illness have unique experiences that can affect their school functioning, such that they may miss ongoing periods of school, experience difficulties with schoolwork or experience changes in their peer and teacher interactions. This review provides an overview of these siblings' school experiences. ELIGIBILITY CRITERIA: Six databases (Medline, PsychINFO, CINAHL, ERIC, Embase and The Cochrane Library) were systematically searched for studies examining the school experiences and peer relationships of siblings of children with chronic illness, as well as school-based interventions for these siblings...
December 13, 2016: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/27893064/effect-of-increased-enteral-protein-intake-on-growth-in-human-milk-fed-preterm-infants-a-randomized-clinical-trial
#7
Christoph Maas, Michaela Mathes, Christine Bleeker, Julia Vek, Wolfgang Bernhard, Cornelia Wiechers, Andreas Peter, Christian F Poets, Axel R Franz
Importance: Protein, supplied in currently available commercial fortifiers, may be inadequate to meet the requirements of very preterm infants; in addition, intraindividual and interindividual variability of human milk protein and energy content potentially contribute to unsatisfactory early postnatal growth. Objective: To determine effects on growth of different levels of enteral protein supplementation in predominantly human milk-fed preterm infants. Design, Setting, and Participants: This randomized clinical and partially blinded single-center trial was conducted in a neonatal tertiary referral center in Germany...
January 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27890717/ecdysone-receptor-ecr-and-ultraspiracle-usp-genes-from-the-cyclopoid-copepod-paracyclopina-nana-identification-and-expression-in-response-to-water-accommodated-fractions-wafs
#8
Jayesh Puthumana, Min-Chul Lee, Jeonghoon Han, Hui-Su Kim, Dae-Sik Hwang, Jae-Seong Lee
Ecdysteroid hormones are pivotal in the development, growth, and molting of arthropods, and the hormone pathway is triggered by binding ecdysteroid to a heterodimer of the two nuclear receptors; ecdysone receptors (EcR) and ultraspiracle (USP). We have characterized EcR and USP genes, and their 5'-untranslated region (5'-UTR) from the copepod Paracyclopina nana, and studied mRNA transcription levels in post-embryonic stages and in response to water accommodated fractions (WAFs) of crude oil. The open reading frames (ORF) of EcR and USP were 1470 and 1287bp that encoded 490 and 429 amino acids with molecular weight of 121...
February 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27853341/effect-of-the-wide-spread-use-of-endovenous-laser-ablation-on-the-treatment-of-varicose-veins-in-japan-a-large-scale-single-institute-study
#9
Masatoshi Jibiki, Tetsuro Miyata, Sachiko Futatsugi, Mitsumasa Iso, Yasutaka Sakanushi
Background and aims: In Japan, stripping under general anesthesia, lumbar anesthesia and tumescent local anesthesia has been used in the treatment of primary varicose veins due to saphenous vein insufficiency. However endovenous laser ablation (EVLA) using a 980 nm diode laser has received National Health Insurance (NHI) coverage in 2011, while EVLA using a 1470 nm diode laser with a radial 2-ring fiber has received coverage in 2014. As a result, the use of EVLA has become widespread in Japan. We herein report on the results of varicose veins treatment at our hospital...
October 1, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27851106/1470-antibiotics-prescription-is-not-associated-with-prognosis-in-sepsis-a-prospective-cohort-study
#10
Fabian Jaimes, Pablo Castaño, Maribel Plaza, Fernando Molina, Carolina Hincapie, Wilmar Maya, Juan Cataño, Alba Leon
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27806696/large-scale-gene-co-expression-network-as-a-source-of-functional-annotation-for-cattle-genes
#11
Hamid Beiki, Ardeshir Nejati-Javaremi, Abbas Pakdel, Ali Masoudi-Nejad, Zhi-Liang Hu, James M Reecy
BACKGROUND: Genome sequencing and subsequent gene annotation of genomes has led to the elucidation of many genes, but in vertebrates the actual number of protein coding genes are very consistent across species (~20,000). Seven years after sequencing the cattle genome, there are still genes that have limited annotation and the function of many genes are still not understood, or partly understood at best. Based on the assumption that genes with similar patterns of expression across a vast array of tissues and experimental conditions are likely to encode proteins with related functions or participate within a given pathway, we constructed a genome-wide Cattle Gene Co-expression Network (CGCN) using 72 microarray datasets that contained a total of 1470 Affymetrix Genechip Bovine Genome Arrays that were retrieved from either NCBI GEO or EBI ArrayExpress...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27779766/investigating-economic-specialization-on-the-central-peruvian-coast-a-reconstruction-of-late-intermediate-period-ychsma-diet-using-stable-isotopes
#12
Sara J Marsteller, Natalya Zolotova, Kelly J Knudson
OBJECTIVES: Hypothetical models of socioeconomic organization in pre-Columbian societies generated from the rich ethnohistoric record in the New World require testing against the archaeological and bioarchaeological record. Here, we test ethnohistorian Maria Rostworowski's horizontality model of socioeconomic specialization for the Central Andean coast by reconstructing dietary practices in the Late Intermediate Period (c. AD 900-1470) Ychsma polity to evaluate complexities in social behaviors prior to Inka imperial influence...
October 25, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27763717/additive-effects-of-the-rho-kinase-inhibitor-y-27632-and-vardenafil-on-relaxation-of-the-corpus-cavernosum-tissue-of-patients-with-erectile-dysfunction-and-clinical-phosphodiesterase-type-5-inhibitor-failure
#13
Pieter Uvin, Maarten Albersen, Ine Bollen, Maarten Falter, Emmanuel Weyne, Loes Linsen, Hanna Tinel, Peter Sandner, Trinity J Bivalacqua, Dirk J M K De Ridder, Frank Van der Aa, Bert Brône, Koenraad Van Renterghem
OBJECTIVES: To evaluate the expression of the Rho/Rho-associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to test the functional effects of two Rho kinase inhibitors (RKIs) on erectile tissue of patients with severe ED, which did not respond to phosphodiesterase type 5 inhibitors (PDE5Is). PATIENTS AND METHODS: Human corpus cavernosum samples were obtained after consent from men undergoing penile prosthesis implantation (n = 7 for organ bath experiments, n = 17 for quantitative PCR [qPCR])...
October 20, 2016: BJU International
https://www.readbyqxmd.com/read/27731620/magnetic-nanospheres-encapsulated-by-mesoporous-copper-oxide-shell-for-selective-isolation-of-hemoglobin
#14
Zhiyong Guo, Yue Zhang, Dan-Dan Zhang, Yang Shu, Xu-Wei Chen, Jian-Hua Wang
A novel strategy for the preparation of magnetic nanospheres encapsulated by mesoporous copper oxide shell, shortly termed as Fe3O4@mCuO, is reported via the calcination of Cu(NH3)4(NO3)2 into continuous mesoporous CuO shell onto the surface of Fe3O4 nanoparticles. The magnetic nanospheres are characterized to possess stable core-shell structure with a crystalline mesoporous CuO layer, exhibiting a CuO loading content of 25.2±1.1% along with a favorable magnetic susceptibility. Fe3O4@mCuO nanospheres exhibit favorable selectivity on the adsorption of hemoglobin with a high adsorption capacity of up to 1470...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27721562/four-different-diode-lasers-comparison-on-soft-tissues-surgery-a-preliminary-ex-vivo-study
#15
Carlo Fornaini, Elisabetta Merigo, Michele Sozzi, Jean-Paul Rocca, Federica Poli, Stefano Selleri, Annamaria Cucinotta
Objectives: The introduction of diode lasers in dentistry had several advantages, principally consisting on the reduced size, reduced cost and possibility to beam delivering by optical fibbers. Up today only the wavelengths around 810 and 980 nm were the most utilized in oral surgery but recently more different lasers had been proposed. The aim of this study was to compare the efficacy of four diode laser wavelengths (810, 980, 1470 and 1950 nm) for the ablation of soft tissues. Material and methods: Specimens were surgically collected from the dorsal surface of four bovine tongues and irradiated by four different diode wavelengths...
June 29, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27696274/early-rehabilitation-benefits-in-patients-with-severe-acquired-brain-injury
#16
Rita Formisano, Eva Azicnuda, Maryam Khan Sefid, Mauro Zampolini, Federico Scarponi, Renato Avesani
Establish the best time to start rehabilitation by means of scientific evidence. Observational study in patients with a diagnosis of Severe Brain Injury who received intensive inpatient rehabilitation after acute care. 1470 subjects enrolled: 651 with Traumatic Brain Injury (TBI) and 819 with Non-TBI. Male gender was prevalent in the population study, but sex distribution was not different among groups, with a prevalence of male gender in both populations. This project involved 29 rehabilitation facilities for Severe ABI...
October 1, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27627862/exploring-imperial-expansion-using-an-isotopic-analysis-of-paleodietary-and-paleomobility-indicators-in-chachapoyas-peru
#17
J Marla Toyne, Warren B Church, Jose Luis Coronado Tello, Ricardo Morales Gamarra
OBJECTIVES: Inca imperial strategies of political and territorial expansion varied across conquered regions depending on local ecology and cultural resistance, and Chachapoya peoples in Peru's forested northeastern Andes were renowned for their rebellions against the invaders. The cliff tombs of Los Pinchudos (AD 1470-1535) present opportunities to use stable isotopes to: (1) explore dietary and mobility patterns from a mortuary community interred at a site attributed to the poorly-known Chachapoya culture during the period of Inca domination, and (2) explore the origins of the individuals as either local or foreign (Inca)...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27614260/lower-rates-of-consistent-urine-drug-tests-for-prescribed-psychotropic-medications-among-patients-on-opioid-replacement-therapy
#18
Ahmed N Hassan
BACKGROUND: Patients on opioid replacement therapy (ORT) to treat opioid use disorder are frequently monitored for these medications, but it is not known if they are also adhering to their psychotropic medications. This is an analysis of measure of potential adherence to psychotropic medications by patients on ORT. METHODS: This is a retrospective cohort study of patients (n=1470) on antidepressants and/or antipsychotics and tested by the Millennium Health laboratory...
November 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27598344/effects-of-varieties-producing-areas-ears-and-ear-positions-of-single-maize-kernels-on-near-infrared-spectra-for-identification-and-traceability
#19
Dong An, Yongjin Cui, Xu Liu, Shiqiang Jia, Shuyun Zheng, Xiaoping Che, Zhe Liu, Xiaodong Zhang, Dehai Zhu, Shaoming Li
The effects of varieties, producing areas, ears, and ear positions of maize on near-infrared (NIR) spectra were investigated to determine the factors causing the differences in NIR fingerprints of maize varieties. A total of 130 inbred lines were grown in two regions in China, and 12,350 kernel samples were analyzed through NIR spectroscopy. Spectral differences among varieties, producing areas, ears, and ear positions were determined and compared on the basis of pretreated spectra. The bands at 1300-1470, 1768-1949, 2010-2064, and 2235-2311 nm were mainly affected by the producing area...
2016: PloS One
https://www.readbyqxmd.com/read/27586096/changing-threshold-for-ais-scores-of-thoracolumbar-compression-fractures
#20
Hesham M Soliman, Ha Son Nguyen, Anjishnu Banerjee, Frank Pintar, Narayan Yoganandan, Shekar Kurpad, Dennis Maiman
BACKGROUND: The Abbreviated Injury Scale (AIS) is an anatomical-based coding system created by the Association for the Advancement of Automotive Medicine, utilized to classify and code injuries resulting from trauma, in order of severity. According to the latest version, all Thoraco-Lumbar Compression Fractures (TLCF), even without injury to other spine components and with >20% loss of height, were branded AIS 3 injuries, reflecting a serious threat to life or permanent disability...
September 2016: Traffic Injury Prevention
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