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Pneumonia childhood

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https://www.readbyqxmd.com/read/29785832/lectin-microarray-combined-with-mass-spectrometry-identifies-haptoglobin-related-protein-hpr-as-a-potential-serologic-biomarker-for-separating-non-bacterial-pneumonia-from-bacterial-pneumonia-in-childhood
#1
Lin Yang, Zhou Yang, Lei Cheng, Juan Cheng, Li Cheng, Yangyang Sun, Wenting Li, Kai Song, Weichun Huang, Yong Yin, Shengce Tao, Qinghua Zhang
PURPOSE: Etiological diagnosis of pediatric patients with community-acquired pneumonia is difficult. For therapy, one of the major problems is the difficulty in separating bacterial pneumonia which would benefit from antibiotics from non-bacterial pneumonia. Therefore, we sought to identify potential biomarkers for distinguishing non-bacterial pneumonia from bacterial pneumonia. EXPERIMENTAL DESIGN: Lectin microarray containing 91 lectins was used to screen serums from pediatric patients with pneumonia...
May 22, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29785130/human-herpesvirus-6-pneumonitis-in-a-patient-with-follicular-lymphoma-following-immunochemotherapy-with-rituximab
#2
Saeko Kuwahara-Ota, Yoshiaki Chinen, Yoshimi Mizuno, Tomoko Takimoto-Shimomura, Yayoi Matsumura-Kimoto, Kazuna Tanba, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Junya Kuroda
Primary infection with human herpesvirus-6 (HHV-6) commonly occurs at an early age in children, most often at 3 years of age, and is associated with childhood diseases, such as exanthema subitum, hepatitis, febrile convulsions, or encephalitis. However, the virus occasionally reactivates from its latent state in immunosuppressed adults, especially post-transplant, resulting in serious disseminated, sometimes life-threatening end-organ complications. Herein, we report a case of a 68-year-old man with relapsed follicular lymphoma who developed HHV-6 pneumonitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#3
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29751582/whole-exome-sequencing-identifies-new-host-genomic-susceptibility-factors-in-empyema-caused-by-streptococcus-pneumoniae-in-children-a-pilot-study
#4
Antonio Salas, Jacobo Pardo-Seco, Ruth Barral-Arca, Miriam Cebey-López, Alberto Gómez-Carballa, Irene Rivero-Calle, Sara Pischedda, María-José Currás-Tuala, Jorge Amigo, José Gómez-Rial, Federico Martinón-Torres
Pneumonia is the leading cause of death amongst infectious diseases. Streptococcus pneumoniae is responsible for about 25% of pneumonia cases worldwide, and it is a major cause of childhood mortality. We carried out a whole exome sequencing (WES) study in eight patients with complicated cases of pneumococcal pneumonia (empyema). An initial assessment of statistical association of WES variation with pneumonia was carried out using data from the 1000 Genomes Project (1000G) for the Iberian Peninsula (IBS) as reference controls...
May 3, 2018: Genes
https://www.readbyqxmd.com/read/29749357/-mycoplasma-pneumoniae-a-significant-but-underrated-pathogen-in-paediatric-community-acquired-lower-respiratory-tract-infections
#5
REVIEW
Surinder Kumar
Lower respiratory tract infections are considered a common cause responsible for morbidity and mortality among children, and Mycoplasma pneumoniae is identified to be responsible for up to 40 per cent of community-acquired pneumonia in children greater than five years of age. Extrapulmonary manifestations have been reported either due to spread of infection or autoimmune mechanisms. Infection by M. pneumoniae has high incidence and clinical importance but is still an underrated disease. Most widely used serologic methods are enzyme immunoassays for detection of immunoglobulin M (IgM), IgG and IgA antibodies to M...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29746496/pharyngeal-colonization-and-drug-resistance-profiles-of-morraxella-catarrrhalis-streptococcus-pneumoniae-staphylococcus-aureus-and-haemophilus-influenzae-among-hiv-infected-children-attending-art-clinic-of-felegehiwot-referral-hospital-ethiopia
#6
Wondemagegn Mulu, Endalew Yizengaw, Megbaru Alemu, Daniel Mekonnen, Derese Hailu, Kassaw Ketemaw, Bayeh Abera, Mulugeta Kibret
BACKGROUND: Asymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29746377/risk-factors-for-severe-community-acquired-pneumonia-among-children-hospitalized-with-cap-younger-than-5-years-of-age
#7
Wei Shan, Ting Shi, Kaile Chen, Jian Xue, Yin Wang, Jia Yu, Genming Zhao, Jianmei Tian, Tao Zhang
BACKGROUND: CAP causes great morbidity and mortality as well as enormous economic burden worldwide. This study intended to describe the clinical characteristics of CAP and explore the risk factors of severe CAP among children in downtown Suzhou, China. METHODS: This was a retrospective study of childhood hospitalizations in Soochow University Affiliated Children's Hospital (SCH) from January 1, 2010 to December 31, 2014. Children who were residents of downtown Suzhou, 29 days to <5 years of age, with discharge diagnosis codes (ICD-10) J09 to J18 and J20 to J22 were included...
May 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29738266/early-treatment-was-life-saving-in-varicella-pneumonia-of-an-immunocompetent-adult
#8
Neslihan Çelik, Onur Çelik, Onur Ünal
Chickenpox, an infection of childhood with vesicular skin rash, is caused by varicella-zoster virus (VZV). Although the infection is rare in adults, it can cause serious complications Varicella pneumonia is the most encountered complication. In this report, a VZV pneumonia case in a previously healthy adult is presented. The patient was treated with early intravenous acyclovir and both clinical and radiographic recovery has been observed.
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29720526/-pseudomonas-aeruginosa-protease-iv-exacerbates-pneumococcal-pneumonia-and-systemic-disease
#9
Jessica L Bradshaw, Armando R Caballero, Michael A Bierdeman, Kristen V Adams, Haley R Pipkins, Aihua Tang, Richard J O'Callaghan, Larry S McDaniel
Pneumonia is a pulmonary disease affecting people of all ages and is consistently a leading cause of childhood mortality and adult hospitalizations. Streptococcus pneumoniae and Pseudomonas aeruginosa are major lung pathogens commonly associated with community-acquired and nosocomial pneumonia. Additionally, mixed lung infections involving these bacterial pathogens are increasing in prevalence and are frequently more severe than single infections. The cooperative interactions of these two pathogens that impact pulmonary disease severity are understudied...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29720076/paediatric-active-enhanced-disease-surveillance-paeds-annual-report-2015-prospective-hospital-based-surveillance-for-serious-paediatric-conditions
#10
Jocelynne E McRae, Helen E Quinn, Kristine Macartney
Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29710526/xianyu-decoction-attenuates-the-inflammatory-response-of-human-lung-bronchial-epithelial-cell
#11
Chenyi Yu, Qiangwei Xiang, Hailin Zhang
BACKGROUND: Xianyu decoction (XD), a Chinese experience recipe, shows inhibitory effects on lung cancer. However, the potential functions of XD on pneumonia were unknown. This study aimed to investigate the effect of XD on inflammatory response of childhood pneumonia. METHODS: Human lung bronchial epithelial cell line BEAS-2B was cultured in different doses of LPS with or without XD treatment. The expression of miR-15a and IKBKB were altered by transfection assay...
April 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29683419/haemagglutinin-neuraminidase-from-hpiv3-mediates-human-nk-regulation-of-t-cell-proliferation-via-nkp44-and-nkp46
#12
Samantha McQuaid, Sinead Loughran, Patrick Power, Paula Maguire, Dermot Walls, Maria Grazia Cusi, Claes Orvell, Patricia Johnson
HPIV3 is a respiratory virus causing airway diseases, including pneumonia, croup, and bronchiolitis, during infancy and childhood. Currently there is no effective vaccine or anti-viral therapy for this virus. Studies have suggested that poor T cell proliferation following HPIV3 infection is responsible for impaired immunological memory associated with this virus. We have previously demonstrated that NK cells mediate regulation of T cell proliferation during HPIV3 infection. Here we add to these studies by demonstrating that the regulation of T cell proliferation during HPIV3 infection is mediated via NK receptors NKp44 and NKp46 and involves the surface glycoprotein haemagglutinin-neuraminidase but not the fusion protein of the virus...
April 23, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29672858/neonates-colonized-with-pathogenic-bacteria-in-the-airways-have-a-low-grade-systemic-inflammation
#13
Nadia Rahman Fink, Bo Lund Chawes, Jonathan Thorsen, Jakob Stokholm, Karen Krogfelt, Susanne Schjørring, Marie Kragh, Klaus Bønnelykke, Susanne Brix, Hans Bisgaard
BACKGROUND AND OBJECTIVES: The development of childhood asthma is associated with neonatal colonization with pathogenic bacteria in hypopharynx. Furthermore, established asthma is associated with systemic low-grade inflammation. We here report on the association between neonatal colonization with pathogenic bacteria in hypopharynx and the development of systemic low-grade inflammation. METHODS: Bacterial colonization of the hypopharynx with M. catharralis, H. influenzae and/or S...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29670774/emergent-presentation-of-an-adult-with-undiagnosed-coarctation-of-the-aorta
#14
Shannon Armistead, David Mullins, Stephen Sherick, John Ashurst
Coarctation of the aorta is typically thought to be a childhood disease. However, emergency physicians must keep a broad differential diagnosis when faced with a young patient with signs and symptoms of acute congestive heart failure. The authors present a case of newly diagnosed coarctation of the aorta in a 26-year-old male who was first misdiagnosed with pneumonia.
2018: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/29662688/distribution-and-determinants-of-pneumonia-diagnosis-using-integrated-management-of-childhood-illness-guidelines-a-nationally-representative-study-in-malawi
#15
Omolara T Uwemedimo, Todd P Lewis, Elsie A Essien, Grace J Chan, Humphreys Nsona, Margaret E Kruk, Hannah H Leslie
Background: Pneumonia remains the leading cause of child mortality in sub-Saharan Africa. The Integrated Management of Childhood Illness (IMCI) strategy was developed to standardise care in low-income and middle-income countries for major childhood illnesses and can effectively improve healthcare worker performance. Suboptimal clinical evaluation can result in missed diagnoses and excess morbidity and mortality. We estimate the sensitivity of pneumonia diagnosis and investigate its determinants among children in Malawi...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29642833/-management-and-treatment-difficulties-of-multi-drug-resistant-pulmonary-tuberculosis-in-a-pediatric-case
#16
Selda Hançerli Törün, Emine Manolya Acar, Ayper Somer, Gonca Erköse, Dilek Şatana, Zuhal Bayramoğlu, Emine Çalışkan, Zeki Kılıçaslan
Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29628376/childhood-predictors-of-lung-function-trajectories-and-future-copd-risk-a-prospective-cohort-study-from-the-first-to-the-sixth-decade-of-life
#17
Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters, Melanie C Matheson, Shyamali C Dharmage
BACKGROUND: Lifetime lung function is related to quality of life and longevity. Over the lifespan, individuals follow different lung function trajectories. Identification of these trajectories, their determinants, and outcomes is important, but no study has done this beyond the fourth decade. METHODS: We used six waves of the Tasmanian Longitudinal Health Study (TAHS) to model lung function trajectories measured at 7, 13, 18, 45, 50, and 53 years. We analysed pre-bronchodilator FEV1 z-scores at the six timepoints using group-based trajectory modelling to identify distinct subgroups of individuals whose measurements followed a similar pattern over time...
April 5, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29606535/immunochromatography-in-csf-improves-data-on-surveillance-of-s-pneumoniae-meningitis-in-india
#18
Yuvaraj Jayaraman, Sanjay Mehendale, Ranjith Jayaraman, Rosemol Varghese, C P Girish Kumar, Prabu Rajkumar, Bharathy Sukumar, Rajamohanan K, Girija Mohan, Devasena N, Sujatha Sridharan, Narayan Babu, G Mathevan, P Sugandhi Rao, S K Kar, Vikas Manchanda, Anil Kanga, Valsan Philip Verghese, Balaji Veeraraghavan
INTRODUCTION: Streptococcus pneumoniae is a significant cause of childhood bacterial meningitis in India. The United States Food and Drug Administration has licensed an immunochromatographic (ICT) test, Binax® NOW™, to detect the C polysaccharide antigen of S. pneumoniae in cerebrospinal fluids (CSF). Accurate etiological diagnosis of bacterial meningitis in India is essential for effective treatment strategies and preventive interventions. MATERIALS AND METHODS: CSF samples from 2081 children admitted, with clinically suspected bacterial meningitis at 11 sentinel sites of hospital based sentinel surveillance network for bacterial meningitis in India between September 2009 and December 2016 were tested with ICT...
March 29, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29605214/burden-of-pneumococcal-community-acquired-pneumonia-in-adults-across-europe-a-literature-review
#19
REVIEW
Antoni Torres, Catia Cillóniz, Francesco Blasi, James D Chalmers, Jacques Gaillat, Nathalie Dartois, Heinz-Josef Schmitt, Tobias Welte
BACKGROUND: The burden of community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae (pneumococcus) among adults in Europe is poorly defined. METHODS: Structured searches of PubMed were conducted to identify the incidence of pneumococcal CAP among adults across Europe. RESULTS: The overall incidence rates for CAP was 68-7000 per 100,000 and the incidence in hospitalised CAP cases of all causes was 16-3581 per 100,000. In general the incidence of CAP increased consistently with age...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29605210/a-review-of-the-etiology-and-clinical-presentation-of-non-cystic-fibrosis-bronchiectasis-a-tertiary-care-experience
#20
Ozlem Satırer, Ayse Mete Yesil, Nagehan Emiralioglu, Gökcen Dilsa Tugcu, Ebru Yalcın, Deniz Dogru, Nural Kiper, Ugur Ozcelik
INTRODUCTION: Non-cystic fibrosis(CF) bronchiectasis has been recognized in children for the past 200 years. Early childhood pneumonia and underlying conditions such as immunodeficiency, primary ciliary dyskinesia(PCD), and congenital lung pathology should be considered in the etiology. The aim of our study was to describe the clinical characteristics, laboratory, and radiological findings of a large population of patients with non-CF bronchiectasis at a tertiary center. METHODS: We analyzed the clinical findings of 187 patients diagnosed with non-CF bronchiectasis over a period of 10 years (January 2005-December 2015) at the Hacettepe University Faculty of Medicine Department of Pediatric Pulmonology...
April 2018: Respiratory Medicine
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