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https://www.readbyqxmd.com/read/28823142/oncogenes-mitochondrial-metabolism-and-quality-control-in-differentiated-thyroid-cancer
#1
Hyon-Seung Yi, Joon Young Chang, Koon Soon Kim, Minho Shong
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a good prognosis with surgical removal and radioiodine treatment. However, a small proportion of patients present with advanced thyroid cancer and are unusually resistant to current drug treatment modalities. Thyroid tumorigenesis is a complex process that is regulated by the activation of oncogenes, inactivation of tumor suppressors, and alterations in programmed cell death...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823140/pre-existing-arterial-pathologic-changes-affecting-arteriovenous-fistula-patency-and-cardiovascular-mortality-in-hemodialysis-patients
#2
Ja Young Lee, Young Ok Kim
The radiocephalic arteriovenous fistula (AVF) provides optimal vascular access for hemodialysis; it has a higher long-term patency rate and fewer complications than other vascular access methods. However, the AVF has a high primary failure rate. The presence of small-diameter vessels at anastomosis sites is an important risk factor for AVF failure. However, in a recent study, despite selecting an adequate artery and vein for creating an AVF by routine preoperative vascular mapping, AVF maturation and primary failure occurred...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823105/understanding-peripartum-depression-through-neuroimaging-a-review-of-structural-and-functional-connectivity-and-molecular-imaging-research
#3
REVIEW
Christy Duan, Jessica Cosgrove, Kristina M Deligiannidis
PURPOSE OF REVIEW: Imaging research has sought to uncover brain structure, function, and metabolism in women with postpartum depression (PPD) as little is known about its underlying pathophysiology. This review discusses the imaging modalities used to date to evaluate postpartum depression and highlights recent findings. RECENT FINDINGS: Altered functional connectivity and activity changes in brain areas implicated in executive functioning and emotion and reward processing have been identified in PPD...
August 19, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28823102/the-etiology-of-primary-hyperhidrosis-a-systematic-review
#4
REVIEW
Moshe Hashmonai, Alan E P Cameron, Cliff P Connery, Noel Perin, Peter B Licht
PURPOSE: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. METHODS: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed...
August 19, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28823101/predictors-of-disordered-eating-in-young-males
#5
R Doumit, J Abi Kharma, M J Sanchez-Ruiz, N Zeeni
Recent findings suggest that disordered eating (DE) symptomatology may be underestimated in the male population. The present study examined depressive symptomatology as a potential mediator of the relationships between body image dissatisfaction, strategies to change body weight and muscles, media pressure, and DE (emotional, restrained and emotional eating) in 260 male undergraduates who completed a self-reported questionnaire. Path analyses indicated that media influence and strategies to decrease body weight had direct positive effects on depressive symptomatology, which in turn predicted emotional eating...
August 19, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28823097/epitope-mapping-of-histo-blood-group-antigens-bound-to-norovirus-vlps-using-std-nmr-experiments-reveals-fine-details-of-molecular-recognition
#6
Brigitte Fiege, Mila Leuthold, Francisco Parra, Kevin P Dalton, Peter J Meloncelli, Todd L Lowary, Thomas Peters
Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be critical for the infection process. Therefore, we have determined binding epitopes of synthetic type 1 to 6 blood group A- and B-tetrasaccharides binding to GII.4 human Norovirus virus like particles (VLPs) using STD NMR experiments. So far, little information is available from crystal structure analysis studies on the interactions of the reducing-end sugars with the protruding domain (P-domain) of the viral coat protein VP1...
August 19, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28823091/trauma-ptsd-and-the-developing-brain
#7
REVIEW
Ryan J Herringa
PURPOSE OF REVIEW: PTSD in youth is common and debilitating. In contrast to adult PTSD, relatively little is known about the neurobiology of pediatric PTSD, nor how neurodevelopment may be altered. This review summarizes recent neuroimaging studies in pediatric PTSD and discusses implications for future study. RECENT FINDINGS: Pediatric PTSD is characterized by abnormal structure and function in neural circuitry supporting threat processing and emotion regulation...
August 19, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28823071/accelerating-the-integration-of-distributed-water-solutions-a-conceptual-financing-model-from-the-electricity-sector
#8
Kimberly J Quesnel, Newsha K Ajami, Noemi Wyss
Modern challenges require new approaches to urban water management. One solution in the portfolio of potential strategies is the integration of distributed water infrastructure, practices, and technologies into existing systems. However, many practical barriers have prevented the widespread adoption of these systems in the US. The objective of this paper is to address these challenges by developing a conceptual model encompassing regulatory, financial, and governance components that can be used to incorporate new distributed water solutions into our current network...
August 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28823009/proton-pump-inhibitors-as-risk-factor-for-metabolic-syndrome-and-hepatic-steatosis-in-coeliac-disease-patients-on-gluten-free-diet
#9
Nicola Imperatore, Raffaella Tortora, Testa Anna, Nicolò Gerbino, Nicola Caporaso, Antonio Rispo
BACKGROUND: Recent research has shown that patients with coeliac disease (CD) are at risk of developing metabolic syndrome (MS) and hepatic steatosis (HS) after commencing a gluten-free diet (GFD). This study aimed to evaluate the predictive factors for MS and HS in CD after 1 year of GFD. METHODS: All consecutive newly diagnosed CD patients were enrolled. We prospectively collected data about BMI; waist circumference; blood pressure; cholesterol; triglycerides, glucose and insulin blood levels; insulin resistance (through the homeostatic model assessment HOMA-IR) and treatment with proton pump inhibitors (PPI)...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28823005/normocalcaemic-primary-hyperparathyroidism-a-diagnostic-and-therapeutic-algorithm
#10
Joaquín Gómez-Ramírez, Radu Mihai
In recent years, there has been increasing interest in understanding the implications of diagnosing normocalcaemic primary hyperparathyroidism (nPHPT). Many patients hope that nPHPT might explain some of their symptoms, but surgeons hesitate to offer treatment to patients whose calcium levels are normal but whose parathyroid hormone (PTH) levels are elevated in the absence of secondary causes of hyperparathyroidism. This potential new diagnosis is not well understood and may lead to inappropriate investigation and possible unnecessary operations...
August 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28822994/glucagon-like-peptide-1-receptor-agonist-stimulates-mitochondrial-bioenergetics-in-human-adipocytes
#11
Joanna Góralska, Agnieszka Śliwa, Anna Gruca, Urszula Raźny, Monika Chojnacka, Anna Polus, Bogdan Solnica, Małgorzata Malczewska-Malec
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are relatively new pharmacological agents used to normalize glucose level in type 2 diabetes. Recently, GLP-1RAs have been approved for the treatment of obesity to reduce body weight in non-diabetic patients. The extra-pancre-atic effects of GLP-1RAs, as well as their molecular mechanism of action, are still poorly understood. Thus this study was aimed to verify the hypothesis that the mechanism of action of the GLP-1RAs involves mitochondria and that GLP-1RAs administration can improve mitochondrial functions...
August 19, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28822984/tbk1-mutations-in-italian-patients-with-amyotrophic-lateral-sclerosis-genetic-and-functional-characterisation
#12
Laura Pozzi, Fabiola Valenza, Lorena Mosca, Andrea Dal Mas, Teuta Domi, Alessandro Romano, Claudia Tarlarini, Yuri Matteo Falzone, Lucio Tremolizzo, Gianni Sorarù, Federica Cerri, Pilar M Ferraro, Silvia Basaia, Federica Agosta, Raffaella Fazio, Mauro Comola, Giancarlo Comi, Maurizio Ferrari, Angelo Quattrini, Christian Lunetta, Silvana Penco, Dario Bonanomi, Paola Carrera, Nilo Riva
BACKGROUND: TANK-binding kinase 1 (TBK1) gene has been recently identified as a causative gene of amyotrophic lateral sclerosis (ALS). METHODS: We sequenced the TBK1 gene in a cohort of 154 Italian patients with ALS with unclear genetic aetiology. We subsequently assessed the pathogenic potential of novel identified TBK1 variants using functional in vitro studies: expression, targeting and activity were evaluated in patient-derived fibroblasts and in cells transfected with mutated-TBK1 plasmids...
August 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28822983/impulsivity-in-parkinson-s-disease-is-associated-with-altered-subthalamic-but-not-globus-pallidus-internus-activity
#13
Peter Justin Rossi, Jonathan B Shute, Enrico Opri, Rene Molina, Corinna Peden, Oscar Castellanos, Kelly D Foote, Aysegul Gunduz, Michael S Okun
BACKGROUND: A significant subset of patients with Parkinson's disease (PD) suffer from impulse control disorders (ICDs). A hallmark feature of many ICDs is the pursuit of rewarding behaviours despite negative consequences. Recent evidence implicates the subthalamic nucleus (STN) and globus pallidus internus (GPi) in reward and punishment processing, and deep brain stimulation (DBS) of these structures has been associated with changes in ICD symptoms. METHODS: We tested the hypothesis that in patients with PD diagnosed with ICD, neurons in the STN and GPi would be more responsive to reward-related stimuli and less responsive to loss-related stimuli...
August 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28822966/inhibitory-actions-of-the-nrg-1-erbb4-pathway-in-macrophages-during-tissue-fibrosis-in-heart-skin-and-lung
#14
Zarha Vermeulen, Anne-Sophie Hervent, Lindsey Dugaucquier, Leni Vandekerckhove, Miche Rombouts, Matthias Beyens, Dorien M Schrijvers, Guido R Y De Meyer, Stuart Maudsley, Gilles W De Keulenaer, Vincent Fm Segers
The neuregulin-1 (NRG-1)/ErbB system is an endothelium-controlled paracrine system modulating cardiac performance and adaptation. Recent studies indicate that NRG-1 has anti-fibrotic effects in the left ventricle (LV), which were explained by direct actions on cardiac fibroblasts. However, the NRG-1/ErbB system also regulates the function of macrophages. In this study, we hypothesized that the anti-fibrotic effect of NRG-1 in the heart is at least partially mediated through inhibitory effects on macrophages...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822963/%C3%AE-1a-subtype-adrenergic-agonist-therapy-for-failing-right-ventricle
#15
Patrick M Cowley, Guan-Ying Wang, Sunil K Joshi, Philip M Swigart, David H Lovett, Paul C Simpson, Anthony J Baker
Failure of the right ventricle (RV) is a serious disease with a poor prognosis and limited treatment options. Signaling by α1-adrenergic receptors (α1-ARs), in particular the α1A-subtype, mediate cardioprotective effects in multiple heart failure models. Recent studies show that chronic treatment with the α1A-subtype agonist A61603 improves function and survival in a model of LV failure. The goal of this study was to determine if chronic A61603 treatment is beneficial in a RV failure model. We used tracheal instillation of the fibrogenic antibiotic bleomycin in mice to induce pulmonary fibrosis, pulmonary hypertension, and RV failure within 2 wk...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28822936/influence-of-coupled-ocean-atmosphere-phenomena-on-the-greater-horn-of-africa-droughts-and-their-implications
#16
Freddie Mpelasoka, Joseph L Awange, Ayalsew Zerihun
Drought-like humanitarian crises in the Greater Horn of Africa (GHA) are increasing despite recent progress in drought monitoring and prediction efforts. Notwithstanding these efforts, there remain challenges stemming from uncertainty in drought prediction, and the inflexibility and limited buffering capacity of the recurrent impacted systems. The complexity of the interactions of ENSO, IOD, IPO and NAO, arguably remains the main source of uncertainty in drought prediction. To develop practical drought risk parameters that potentially can guide investment strategies and risk-informed planning, this study quantifies, drought characteristics that underpin drought impacts management...
August 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28822922/prevalence-and-socio-demographic-characteristics-of-disability-in-older-adults-in-china-findings-from-china-comprehensive-geriatric-assessment-study
#17
Lina Ma, Zhenzhen Li, Zhe Tang, Fei Sun, Lijun Diao, Jian Li, Yao He, Birong Dong, Yun Li
OBJECTIVE: Disability affects older adults' quality of life. This study aimed to examine the socio-demographic characteristics of disability in older adults in China. METHOD: Data was obtained from the China Comprehensive Geriatric Assessment Study (CCGAS). The sample comprised 6864 people aged 60 years and above from seven provinces in China. A door-to-door survey was conducted by formally trained interviewers using a unified questionnaire. Disability was assessed with physical health assessment comprising activities of daily living (ADL), and independent activities of daily living (IADL)...
August 3, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28822896/giving-what-one-should-explanations-for-the-knowledge-behavior-gap-for-altruistic-giving
#18
REVIEW
Peter R Blake
Several studies have shown that children struggle to give what they believe that they should: the so-called knowledge-behavior gap. Over a dozen recent Dictator Game studies find that, although young children believe that they should give half of a set of resources to a peer, they typically give less and often keep all of the resources for themselves. This article reviews recent evidence for five potential explanations for the gap and how children close it with age: self-regulation, social distance, theory of mind, moral knowledge and social learning...
August 7, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28822847/intestinal-adaptations-following-bariatric-surgery-towards-the-identification-of-new-pharmacological-targets-for-obesity-related-metabolic-diseases
#19
REVIEW
Lara Ribeiro-Parenti, Jean-Baptiste Cavin, Maude Le Gall
Although the gastrointestinal tract is the primary target of bariatric surgery, its contributions to the metabolic changes observed after surgery are still underestimated. Changes in the number of incretin-producing cells could result in the modified hormonal response seen after surgery. Additionally, the rate of absorption and consumption of glucose could contribute to the ameliorated glycaemia. Moreover, decreased intestinal permeability could prevent endotoxemia. Recently, numerous studies have focused on intestinal adaptation following bariatric surgeries...
August 17, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28822787/global-regional-and-national-deaths-prevalence-disability-adjusted-life-years-and-years-lived-with-disability-for-chronic-obstructive-pulmonary-disease-and-asthma-1990-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#20
(no author information available yet)
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year...
August 16, 2017: Lancet Respiratory Medicine
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