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https://www.readbyqxmd.com/read/29471586/inflammatory-back-pain-and-axial-spondyloarthritis-lessons-for-clinical-practice-and-epidemiological-research
#1
EDITORIAL
Maureen Dubreuil, Joachim Sieper
The delay between symptom onset and diagnosis in axial spondyloarthritis (axSpA) remains unacceptably long; recently estimated to still be more than 6 years.1 Accumulating data demonstrates that early treatment with TNF-inhibitors reduces both disease activity and radiographic progression in ankylosing spondylitis, the prototypic form of axSpA.2 3 To encourage timely and correct diagnosis and enable early treatment, strategies to better identify patients with axSpA have been studied in several populations.4 This article is protected by copyright...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471580/prevalence-of-early-and-late-prematurity-is-similar-among-pediatric-type-1-diabetes-mellitus-patients-and-the-general-population
#2
Adi Adar, Shlomit Shalitin, Ori Eyal, Neta Loewenthal, Orit Pinhas-Hamiel, Milana Levy, Orna Dally-Gottfried, Zohar Landau, Amnon Zung, Floris Levy-Khademi, David Zangen, Yardena Tenenbaum-Rakover, Marianna Rachmiel
BACKGROUND: The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children. METHODS: A nationwide cross-sectional study was conducted, with linkage of data from 13 pediatric diabetes centers and Israeli National Registries, including T1DM patients and general non-T1DM population, born during 2000-2013...
February 22, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29471546/longitudinal-analyses-of-blood-transcriptome-during-conversion-to-psychosis
#3
Boris Chaumette, Oussama Kebir, Juliette Pouch, Bertrand Ducos, Fekrije Selimi, Raphael Gaillard, Marie-Odile Krebs
The biological processes associated with the onset of schizophrenia remain largely unknown. Current hypotheses favor gene × environment interactions as supported by our recent report about DNA methylation changes during the onset of psychosis. Here, we conducted the first longitudinal transcriptomic analysis of blood samples from 31 at-risk individuals who later converted to psychosis and 63 at-risk individuals who did not. Individuals were followed for a maximum of 1 year. Blood samples were collected at baseline and at the end of follow-up and individuals served as their own controls...
February 17, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471488/morphological-responses-of-plant-roots-to-mechanical-stress
#4
Izabela Potocka, Joanna Szymanowska-Pulka
Background: Roots are continuously exposed to mechanical pressure and this often results in their morphological modification. Most obvious are changes in the overall form of the root system as well as in the shapes of particular roots. These changes are often accompanied by modifications of the cell pattern and cell morphology. Scope: This review focuses on the morphological responses of roots to mechanical stress. Results of early and recent experiments in which roots have been exposed to mechanical pressure are assembled, analysed and discussed...
February 17, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29471425/foxl2c134w-induced-cyp19-expression-via-cooperation-with-smad3-in-hgrc1-cells
#5
Martina Belli, Nahoko Iwata, Tomoko Nakamura, Akira Iwase, Dwayne Stupack, Shunichi Shimasaki
Germline knockout studies in female mice demonstrated an essential role for FOXL2 in early follicle development, while an inducible granulosa cell (GC) specific deletion of Foxl2 in adults has shown ovary-to-testis somatic sex reprogramming. In women, over 120 different germline mutations in the FOXL2 gene have been shown to cause blepharophimosis/ptosis/epicantus inversus syndrome associated with or without primary ovarian insufficiency. By contrast, a single somatic mutation (FOXL2C134W) accounts for almost all adult-type GC tumors (aGCTs)...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29471391/comparative-efficacy-of-enrofloxacin-to-that-of-tulathromycin-for-the-control-of-bovine-respiratory-disease-and-prevalence-of-antimicrobial-resistance-in-mannheimia-haemolytica-in-calves-at-high-risk-of-developing-bovine-respiratory-disease
#6
S Crosby, B Credille, S Giguère, R Berghaus
Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. Mannheimia haemolytica (Mh) is the bacterial pathogen most often isolated from cattle with BRD and the prevalence of antimicrobial resistance (AMR) in this organism has increased in recent years. Antimicrobials are commonly used to prevent BRD in cattle at high-risk of developing BRD, however, recent work would suggest that this practice might be one factor contributing to the increased prevalence of AMR in Mh...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471379/do-women-and-men-have-the-same-patterns-of-multiple-occupational-carcinogenic-exposures-results-from-a-cohort-of-cancer-patients
#7
Mélanie Bertin, Annie Thébaud-Mony, Emilie Counil
Complex exposure situations are frequent at the workplace, but few studies have characterized multiple occupational carcinogenic exposures (MOCE) and their gendered differences across jobs' characteristics. We assessed MOCE separately in male and female jobs and identified patterns of MOCE at job level. Participants (834 men and 183 women) were cancer patients recruited between March 2002 and December 2010 in the ongoing SCOP93 cohort study, Seine-Saint-Denis department, France. Job histories were collected through personal interviews, and carcinogenic exposures were assessed by a multidisciplinary expert committee using a list of 53 carcinogens...
February 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29471377/tnf-inhibitor-treatment-is-associated-with-a-lower-risk-of-hand-osteoarthritis-progression-in-rheumatoid-arthritis-patients-after-10-years
#8
Marieke Loef, Féline P B Kroon, Sytske Anne Bergstra, Joy A van der Pol, Willem F Lems, Pit J S M Kerstens, Cornelia F Allaart, Margreet Kloppenburg
Objective: To investigate the effect of TNF inhibitors (TNFis) on incidental and progressive hand OA in recent-onset RA patients after a 10 year follow-up. Methods: Radiographs of 262 RA patients (mean age 52 years, 66% women) from the BeSt study were scored for osteophytes in DIP/PIP joints using the Osteoarthritis Research Society International atlas (0-3; summed score 0-54) and according to the Kellgren-Lawrence (KL) score (0-4; summed score 0-72) at baseline and 10 year follow-up...
February 19, 2018: Rheumatology
https://www.readbyqxmd.com/read/29471370/competitive-ability-of-capsella-species-with-different-mating-systems-and-ploidy-levels
#9
Sandra Petrone Mendoza, Martin Lascoux, Sylvain Glémin
Background and Aims: Capsella is a model genus for studying the transition from outcrossing to selfing, with or without change in ploidy levels. The genomic consequences and changes in reproductive traits (selfing syndrome) associated with these shifts have been studied in depth. However, potential ecological divergence among species of the genus has not been determined. Among ecological traits, competitive ability could be relevant for selfing evolution, as selfing has been shown to be statistically associated with reduced competitiveness in a recent meta-analysis...
February 17, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29471346/refocusing-vector-assessment-towards-the-elimination-of-onchocerciasis-from-africa-a-review-of-the-current-status-in-selected-countries
#10
Daniel Boakye, Jamie Tallant, Aime Adjami, Samfo Moussa, Afework Tekle, Magda Robalo, Maria Rebollo, Pauline Mwinza, Laston Sitima, Paul Cantey, Charles Mackenzie
Measures to control onchocerciasis have been in place for well over 30 years. Recently, programs have turned from disease control towards transmission elimination. The absence of infective larvae in the black fly Simulium sp. vector is central to defining elimination, and assessments of infectivity by O150 polymerase chain reaction in the vector not only provide valuable information to programs, but are also required for verification of elimination. The status of transmission in black flies was assessed in five countries in the African region during 2014 and 2015...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29471331/cross-cultural-validation-and-extension-of-the-clinical-assessment-interview-for-negative-symptoms-cains-in-the-chinese-context-evidence-from-a-spectrum-perspective
#11
Dong-Jie Xie, Hai-Song Shi, Simon S Y Lui, Chuan Shi, Ying Li, Karen K Y Ho, Karen S Y Hung, Wen-Xiu Li, Zheng-Hui Yi, Eric F C Cheung, Ann M Kring, Raymond C K Chan
The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed in accordance with the recent theory and research in social affective neuroscience and to address the psychometric and conceptual limitations of other instruments assessing negative symptoms. The present study aimed to provide a large-scale validation of the CAINS in China and examine its applicability and validity evidence across the schizophrenia spectrum. Using confirmatory factor analysis, our results replicated the original findings in the US development samples that the CAINS possesses a stable 2-factor structure, namely "motivation/pleasure" and "expression"...
February 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471293/neonatal-stress-has-a-long-lasting-sex-dependent-effect-on-anxiety-like-behavior-and-neuronal-morphology-in-the-prefrontal-cortex-and-hippocampus
#12
Silvana Regina de Melo, Caren Tatiane de David Antoniazzi, Shakhawat Hossain, Bryan Kolb
The long-lasting effects of early stress on brain development have been well studied. Recent evidence indicates that males and females respond differently to the same stressor. We examined the chronic effects of daily maternal separation (MS) on behavior and cerebral morphology in both male and female rats. Cognitive and anxiety-like behaviors were evaluated, and neuroplastic changes in 2 subregions of the prefrontal cortex (dorsal agranular insular cortex [AID] and cingulate cortex [Cg3]) and hippocampus (CA1 and dentate gyrus) were measured in adult male and female rats...
February 22, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29471269/how-to-build-a-phagosome-new-concepts-for-an-old-process
#13
REVIEW
Florence Niedergang, Sergio Grinstein
Phagocytosis is a complex and elegant mechanism requiring finely coordinated deformation and restructuring of the membrane and the underlying cytoskeleton. Here we discuss the early events of receptor clustering and engagement required for signal transduction and actin remodeling. In addition, we summarize recent studies of the mechanisms whereby the nascent phagosome seals and evolves into a degradative phagolysosome by a process that seemingly involves the autophagic machinery. These studies provided new insights of the molecular basis of this long-appreciated, essential homeostatic process...
February 19, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29471259/functional-genomics-and-assays-of-regulatory-activity-detect-mechanisms-at-loci-for-lipid-traits-and-coronary-artery-disease
#14
REVIEW
Tamara S Roman, Karen L Mohlke
Many genome-wide association studies (GWAS) have identified signals located in non-coding regions, and an increasing number of functional genomics annotations of regulatory elements and assays of regulatory activity have been used to investigate mechanisms. Genome-wide datasets that characterize chromatin structure help detect potential regulatory elements. Assays to experimentally assess candidate variants include transcriptional reporter assays, and recently, massively parallel reporter assays (MPRAs). Additionally, the effect of candidate regulatory elements and variants on gene expression and function can be evaluated using genomic editing with the CRISPR-Cas9 technology...
February 19, 2018: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29471200/a-review-on-recent-progress-in-the-detection-methods-and-prevalence-of-human-enteric-viruses-in-water
#15
REVIEW
Eiji Haramoto, Masaaki Kitajima, Akihiko Hata, Jason R Torrey, Yoshifumi Masago, Daisuke Sano, Hiroyuki Katayama
Waterborne human enteric viruses, such as noroviruses and adenoviruses, are excreted in the feces of infected individuals and transmitted via the fecal-oral route including contaminated food and water. Since viruses are normally present at low concentrations in aquatic environments, they should be concentrated into smaller volumes prior to downstream molecular biological applications, such as quantitative polymerase chain reaction (qPCR). This review describes recent progress made in the development of concentration and detection methods of human enteric viruses in water, and discusses their applications for providing a better understanding of the prevalence of the viruses in various types of water worldwide...
February 8, 2018: Water Research
https://www.readbyqxmd.com/read/29471166/neurobehavioral-effects-of-two-metabolites-of-bde-47-6-oh-bde-47-and-6-meo-bde-47-on-zebrafish-larvae
#16
Bin Zhang, Ting Xu, Gaofeng Huang, Daqiang Yin, Qing Zhang, Xinyue Yang
Two metabolites, OH-BDEs and MeO-BDEs, of polybrominated diphenyl ethers (PBDEs) were ubiquitously detected in animal tissues and environmental samples, drawing a widely public concern to their toxicity. The comparison of toxicity between PBDEs and their metabolites has been a focus in recent years, however, comparisons seldom involve neurobehavioral toxicity of PBDEs metabolites in published works. In this study, zebrafish larvae were exposed to 6-OH-BDE-47 and 6-MeO-BDE-47 and their neurobehavioral traits (including locomotion, path angle, and social activity) were recorded using the instrument Zebrabox; meanwhile, light illumination was used as stimuli in the test duration...
February 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29471148/photonic-technology-for-the-treatments-of-the-venous-and-arterial-ulcers-case-report
#17
Fernanda Mansano Carbinatto, Antonio Eduardo de Aquino, Vitória Helena Maciel Coelho, Vanderlei S Bagnato
In this report, we recent a case study on a 50-year-old male patient with different chronic wounds, such as venous ulcer and arterial ulcer in both legs. These wounds have persisted for more than 10 years, despite the different treatments applied, between safenectomy, different dressings, hyperbaric camera, as well as the used of several medicines of oral and topical application. The case is addressed with the aim to evaluate if treatment that uses combined techniques such as low level laser therapy (LLLT), photodynamic therapy and cellulose membrane is able to improve healing and reduction of time of treatment in those types of chronic wounds...
February 19, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29471141/the-morphological-and-molecular-mechanisms-of-epithelial-endothelial-to-mesenchymal-transition-and-its-involvement-in-atherosclerosis
#18
REVIEW
M Wesseling, T R Sakkers, S C A de Jager, G Pasterkamp, M J Goumans
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a pathologic feature in the progression of disease or as a response to injury. Endothelial-to-Mesenchymal Transition (EndMT) is a process that is classified as a specialized form of Epithelial-to-Mesenchymal Transition (EMT), in which epithelial cells lose their epithelial characteristics and gain a mesenchymal phenotype. During transdifferentiation, cells lose both cell-cell contacts and their attachment to the basement membrane...
February 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29471116/genetic-populations-and-virulence-factors-of-helicobacter-pylori
#19
REVIEW
Evariste Tshibangu Kabamba, Vo Phuoc Tuan, Yoshio Yamaoka
Helicobacter pylori is a bacterium that has infected more than half of the human population worldwide. This bacterium is closely associated with serious human diseases, such as gastric cancer, and identifying and understanding factors that predict bacterial virulence is a priority. In addition, this pathogen shows high genetic diversity and co-evolution with human hosts. H. pylori population genetics, therefore, has emerged as a tool to track human demographic history. As the number of genome sequences available is increasing, studies on the evolution and virulence of H...
February 19, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29471092/purification-and-functional-characterization-of-recombinant-balsamin-a-ribosome-inactivating-protein-from-momordica-balsamina
#20
Parminder K Ajji, Shailendra P Sonkar, Ken Walder, Munish Puri
Balsamin, a type I ribosome-inactivating protein (RIP), has been shown to inhibit HIV-1 replication at the translation step. Our recent studies have shown that balsamin also possess anti-tumor, antibacterial and DNase-like activity, however, the amount of natural balsamin in Momordica balsamina seeds is limited and preclinical studies require large quantities of pure, bioactive balsamin. Therefore, in this study, we cloned the balsamin gene, expressed it in E. coli BL21(DE3) strain and purified it by nickel affinity chromatography...
February 19, 2018: International Journal of Biological Macromolecules
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