Maíra Terra Garcia, Paulo Henrique Fonseca do Carmo, Lívia Mara Alves Figueiredo-Godoi, Natália Inês Gonçalves, Patrícia Michelle Nagai de Lima, Lucas de Paula Ramos, Luciane Dias de Oliveira, Alexandre Luiz Souto Borges, Anita Shukla, Juliana Campos Junqueira
Candida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively. First, we observed that different GG formulations (0.6 to 1.0% wt/vol) were able to incorporate and release CAPE, reaching a controlled and prolonged release over 180 min at 1...
February 20, 2024: Pharmaceutics