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https://www.readbyqxmd.com/read/28812768/chemical-nutritive-composition-and-a-wide-range-of-bioactive-properties-of-honey-mushroom-armillaria-mellea-vahl-fr-kummer
#1
Marina Kostić, Marija Smiljković, Jovana Petrović, Jasmina Glamočlija, Lillian Barros, Isabel C F R Ferreira, Ana Ćirić, Marina Soković
A. mellea fruiting bodies collected from nature were chemically characterized and shown to be rich in carbohydrates (81.25 g per 100 g dw), ash, fat and proteins (8.84 g per 100 g dw, 1.97 g per 100 g dw and 1.81 g per 100 g dw, respectively). Mannitol was the main free sugar while malic acid was the most abundant organic acid. δ-Tocopherol was the dominant form of tocopherols with 42.41 μg per 100 g dw. Polyunsaturated fatty acids were predominant, followed by saturated and monounsaturated fatty acids. A methanolic extract prepared from these samples was tested for antioxidant, quorum sensing and antimicrobial assays, as well as for its cytotoxicity effects...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28800779/proinflammatory-mg-63-cells-response-infection-with-enterococcus-faecalis-cps2-evaluated-by-the-expression-of-tlr-2-il-1%C3%AE-and-inos-mrna
#2
Boy M Bachtiar, Endang W Bachtiar
OBJECTIVE: We have previously demonstrated that unencapsulated Enterococcus faecalis cps2 inhibits biofilm formation of Candida albicans, a fungus commonly found with E. faecalis in periapical lesion. In this study, we compared encapsulated and unencapsulated E. faecalis cps2 strains relationship with osteoblastic (MG-63) cells, whereas E. faecalis ATCC 29212 were used as a reference strain. RESULTS: The binding capacity of E. faecalis to MG-63 cells as shown by each tested strain was comparable, but the unencapsulated strain was less invasive compared to the encapsulated and the reference strains...
August 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28797969/bioactive-mesoporous-silica-nanostructures-with-anti-microbial-and-anti-biofilm-properties
#3
Paul Cătălin Balaure, Bianca Boarca, Roxana Cristina Popescu, Diana Savu, Roxana Trusca, Bogdan Ștefan Vasile, Alexandru Mihai Grumezescu, Alina Maria Holban, Alexandra Bolocan, Ecaterina Andronescu
The increasing rate of antibiotic resistant bacteria associated with nosocomial infections in severely ill patients has urged the need for new antibacterial therapies. Nanostructured materials represent emerging innovative approaches to controlled delivery of different antimicrobial drugs. Delivery systems encapsulating natural compounds with antibacterial effects, such as essential oils have shown a great potential. Herein we report the development of SiO2 mesoporous nanosystems loaded with eucalyptus (EUC), orange (ORA), and cinnamon (CIN) essential oils...
August 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28793308/genetic-analysis-of-the-candida-albicans-biofilm-transcription-factor-network-using-simple-and-complex-haploinsufficiency
#4
Virginia E Glazier, Thomas Murante, Daniel Murante, Kristy Koselny, Yuan Liu, Dongyeop Kim, Hyun Koo, Damian J Krysan
Biofilm formation by Candida albicans is a key aspect of its pathobiology and is regulated by an integrated network of transcription factors (Bcr1, Brg1, Efg1, Ndt80, Rob1, and Tec1). To understand the details of how the transcription factors function together to regulate biofilm formation, we used a systematic genetic interaction approach based on generating all possible double heterozygous mutants of the network genes and quantitatively analyzing the genetic interactions between them. Overall, the network is highly susceptible to genetic perturbation with the six network heterozygous mutants all showing alterations in biofilm formation (haploinsufficiency)...
August 9, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28792381/effects-of-tea-extracts-on-the-colonization-behaviour-of-candida-species-attachment-inhibition-and-biofilm-enhancement
#5
Yi Wang, H M H N Bandara, Deirdre Mikkelsen, Lakshman P Samaranayake
PURPOSE: We assessed the effects of four different types of tea extracts (green, oolong, black and pu-erh tea) on cellular surface properties (hydrophobicity and auto-aggregation) and the colonization attributes (attachment and biofilm formation) of four strains of Candida albicans and three strains of Candida krusei. METHODOLOGY: The cellular surface properties were determined using spectrophotometry. The colonization activities were quantified using colorimetric viability assays and visualized using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM)...
August 10, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28774698/the-global-problem-of-antifungal-resistance-prevalence-mechanisms-and-management
#6
REVIEW
David S Perlin, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo
All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance greatly hampers patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. The spread of agriculturally derived azole-resistant Aspergillus fumigatus and emerging threats such as multidrug resistant Candida auris are also alarming...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28772791/heat-polymerized-resin-containing-dimethylaminododecyl-methacrylate-inhibits-candida-albicans-biofilm
#7
Hui Chen, Qi Han, Xuedong Zhou, Keke Zhang, Suping Wang, Hockin H K Xu, Michael D Weir, Mingye Feng, Mingyun Li, Xian Peng, Biao Ren, Lei Cheng
The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Flexure strength, bond quality, surface charge density, and surface roughness were measured to evaluate the physical properties of resin...
April 20, 2017: Materials
https://www.readbyqxmd.com/read/28752078/transcriptional-profiling-of-c-albicans-in-a-two-species-biofilm-with-rothia-dentocariosa
#8
Priya Uppuluri, Henk J Busscher, Jaideep Chakladar, Henny C van der Mei, W LaJean Chaffin
Biofilms on silicone rubber voice prostheses are the major cause for frequent failure and replacement of these devices. The presence of both bacterial and yeast strains has been suggested to be crucial for the development of voice prosthetic biofilms. Polymicrobial biofilms that include Candida albicans and Rothia dentocariosa are the leading cause of voice prosthesis failure. An in vitro biofilm comprising these two organisms was developed on silicone rubber, a material used for Groningen button voice prosthesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28747370/survival-persistence-and-isolation-of-the-emerging-multidrug-resistant-pathogenic-yeast-candida-auris-on-a-plastic-healthcare-surface
#9
Rory M Welsh, Meghan L Bentz, Alicia Shams, Hollis Houston, Amanda Lyons, Laura J Rose, Anastasia P Litvintseva
The emerging multidrug-resistant pathogenic yeast Candida auris represents a serious threat to global health. Unlike most other Candida species, this organism appears to be commonly transmitted within healthcare facilities and is capable of causing healthcare-associated outbreaks. To better understand the epidemiology of this emerging pathogen we investigated the ability of C. auris to persist on plastic surfaces common in healthcare settings and compared with that of Candida parapsilosis, a species known to colonize the skin and plastics...
July 26, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28745020/distinct-roles-of-the-7-transmembrane-receptor-protein-rta3-in-regulating-the-asymmetric-distribution-of-phosphatidylcholine-across-the-plasma-membrane-and-biofilm-formation-in-candida-albicans
#10
Archita Srivastava, Shabnam Sircaik, Farha Husain, Edwina Thomas, Shivani Ror, Sumit Rastogi, Darakshan Alim, Priyanka Bapat, David R Andes, Clarissa J Nobile, Sneh L Panwar
Fungal pathogens like Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonize host tissues. Rta3, a member of the Rta1-like family of lipid-translocating exporters has a 7-transmembrane domain (7TMD) topology, similar to the G-protein-coupled receptors (GPCR) and is unique to the fungal kingdom. Our findings point towards a role for the plasma membrane localized Rta3 in providing tolerance to miltefosine, an analog of alkylphosphocholine, by maintaining mitochondrial energetics...
July 25, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28744261/antifungal-potential-of-copper-ii-manganese-ii-and-silver-i-1-10-phenanthroline-chelates-against-multidrug-resistant-fungal-species-forming-the-candida-haemulonii-complex-impact-on-the-planktonic-and-biofilm-lifestyles
#11
Rafael M Gandra, Pauraic Mc Carron, Mariana F Fernandes, Lívia S Ramos, Thaís P Mello, Ana Carolina Aor, Marta H Branquinha, Malachy McCann, Michael Devereux, André L S Santos
Candida haemulonii, Candida haemulonii var. vulnera and Candida duobushaemulonii, which form the C. haemulonii complex, are emerging etiologic agents of fungal infections known to be resistant to the most commonly used antifungals. The well-established anti-Candida potential of metal complexes containing 1,10-phenanthroline (phen) ligands encouraged us to evaluate different copper(II), manganese(II), and silver(I) phen chelates for their ability to inhibit planktonic growth and biofilm of C. haemulonii species complex...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28743811/structural-and-in-vivo-studies-on-trehalose-6-phosphate-synthase-from-pathogenic-fungi-provide-insights-into-its-catalytic-mechanism-biological-necessity-and-potential-for-novel-antifungal-drug-design
#12
Yi Miao, Jennifer L Tenor, Dena L Toffaletti, Stacey A Maskarinec, Jiuyu Liu, Richard E Lee, John R Perfect, Richard G Brennan
The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate analogues. The overall structures of Tps1 from Candida albicans and Aspergillus fumigatus are essentially identical and reveal N- and C-terminal Rossmann fold domains that form the glucose-6-phosphate and UDP-glucose substrate binding sites, respectively...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28730269/emergence-of-candida-glabrata-in-vulvovaginal-candidiasis-should-be-attributed-to-selective-pressure-or-virulence-ability
#13
Sandra Sayuri Nakamura-Vasconcelos, Adriana Fiorini, Pamela Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Janine Ribeiro Godoy, Adriana Araújo Almeida-Apolonio, Marcia Edilaine Lopes Consolaro, Terezinha Inez Estivalet Svidzinski
PURPOSE: Vulvovaginal candidiasis (VVC) is one of the most frequent female genital disorders and Candida glabrata is the second most common agent. Current study was aimed to study the susceptibility to antifungal agents of C. glabrata isolated from vaginal samples and some virulence attributes in order to better understand why this species is emerging as the main VVC agents. METHODS: A total of 60 C. glabrata vaginal isolates were included in this study. Firstly they were screened by susceptibility tests to antifungal agents...
July 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28723923/on-the-mechanism-of-candida-tropicalis-biofilm-reduction-by-the-combined-action-of-naturally-occurring-anthraquinones-and-blue-light
#14
Juliana Marioni, Roger Bresolí-Obach, Montserrat Agut, Laura R Comini, José L Cabrera, María G Paraje, Santi Nonell, Susana C Núñez Montoya
The photoprocesses involved in the photo-induced Candida tropicalis biofilm reduction by two natural anthraquinones (AQs), rubiadin (1) and rubiadin-1-methyl ether (2), were examined. Production of singlet oxygen (1O2) and of superoxide radical anion (O2•-) was studied. Although it was not possible to detect the triplet state absorption of any AQs in biofilms, observation of 1O2 phosphorescence incubated with deuterated Phosphate Buffer Solution, indicated that this species is actually formed in biofilms...
2017: PloS One
https://www.readbyqxmd.com/read/28704490/the-synthetic-killer-peptide-kp-impairs-candida-albicans-biofilm-in-vitro
#15
Simona Paulone, Andrea Ardizzoni, Arianna Tavanti, Serena Piccinelli, Cosmeri Rizzato, Antonella Lupetti, Bruna Colombari, Eva Pericolini, Luciano Polonelli, Walter Magliani, Stefania Conti, Brunella Posteraro, Claudio Cermelli, Elisabetta Blasi, Samuele Peppoloni
Candida albicans is a commensal organism, commonly inhabiting mucosal surfaces of healthy individuals, as a part of the resident microbiota. However, in susceptible hosts, especially hospitalized and/or immunocompromised patients, it may cause a wide range of infections. The presence of abiotic substrates, such as central venous or urinary catheters, provides an additional niche for Candida attachment and persistence, particularly via biofilm development. Furthermore, Candida biofilm is poorly susceptible to most antifungals, including azoles...
2017: PloS One
https://www.readbyqxmd.com/read/28700974/mechanism-of-berberine-mediated-fluconazole-susceptibility-enhancement-in-clinical-fluconazole-resistant-candida-tropicalis-isolates
#16
GaoXiang Shi, Jing Shao, TianMing Wang, DaQiang Wu, ChangZhong Wang
BACKGROUND: Candida tropicalis was one of the most common non-albicans Candida (NACA) species creating relatively high morbidity and mortality. We previously demonstrated that the antifungal effect of BBR in combination with FLC might be attributed to reactive oxygen species production, ergosterol content and efflux pump levels in a clinical C. tropicalis isolate. METHODS: we employed thirteen clinical C. tropicalis isolates as well as four standard reference strains to evaluate the antifungal activity of BBR in combination with FLC under planktonic and biofilm states by analyzing the mRNA expressions of ERG11, CDR1 and MDR1 by qRT-PCR...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28700692/gallic-acid-hydroxypropyl-%C3%AE-cyclodextrin-complex-improving-solubility-for-application-on-in-vitro-in-vivo-candida-albicans-biofilms
#17
Guilherme Rodrigues Teodoro, Aline Vidal Lacerda Gontijo, Aline Chiodi Borges, Márcia Hiromi Tanaka, Gabriela de Morais Gouvêa Lima, Marcos José Salvador, Cristiane Yumi Koga-Ito
The aim of this study was to increase the solubility of gallic acid (GA) for the treatment of Candida albicans biofilm, which is very difficult to treat and requires high drug concentrations. Cyclodextrins (CDs) were used for this purpose. Complexes were evaluated by phase-solubility studies, prepared by spray drying and characterized by drug loading, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The complexes were tested on C. albicans biofilm using in vitro and in vivo models...
2017: PloS One
https://www.readbyqxmd.com/read/28700262/the-sixth-sensor-a-candida-albicans-biofilm-master-regulator-that-responds-to-inter-kingdom-interactions
#18
Nicholas S Jakubovics
No abstract text is available yet for this article.
July 12, 2017: Virulence
https://www.readbyqxmd.com/read/28696240/biofilms-formed-by-isolates-from-recurrent-vulvovaginal-candidiasis-patients-are-heterogeneous-and-insensitive-to-fluconazole
#19
Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E O'Donnell, Rebecca Metcalfe, Brian L Jones, Gordon Ramage
Vulvovaginal candidiasis (VVC) is a global health problem affecting ∼75% of women at least once in their lifetime. Here we examined the epidemiology of VVC from a patient cohort to identify the causative organisms associated with VVC. Biofilm forming capacity and antifungal sensitivity profiles were also assessed. We report a shifting prevalence of Candida species with heterogeneous biofilm forming capacity, both of which are associated with altered antifungal drug sensitivity.
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28695189/risk-of-fungal-infection-to-dental-patients
#20
Jaqueline Lopes Damasceno, Rafael Aparecido Dos Santos, Amir Horiquini Barbosa, Luciana Assirati Casemiro, Regina Helena Pires, Carlos Henrique Gomes Martins
Fungi can cause various diseases, and some pathogenic fungi have been detected in the water of dental equipment. This environment offers suitable conditions for fungal biofilms to emerge, which can facilitate mycological contamination. This study verified whether the water employed in the dental units of two dental clinics at the University of Franca was contaminated with fungi. This study also evaluated the ability of the detected fungi to form biofilms. The high-revving engine contained the largest average amount of fungi, 14...
2017: TheScientificWorldJournal
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