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https://www.readbyqxmd.com/read/28737019/clinical-outcomes-for-patients-presenting-with-n3-head-and-neck-squamous-cell-carcinoma-analysis-of-the-national-cancer-database
#1
Huaising C Ko, Shuai Chen, Aaron M Wieland, Menggang Yu, Andrew M Baschnagel, Gregory K Hartig, Paul M Harari, Matthew E Witek
BACKGROUND: There is a paucity of data regarding head and neck squamous cell carcinomas (HNSCCs) and N3 nodal disease. METHODS: Retrospective analysis of patients with N3 HNSCC identified in the National Cancer Database (NCDB) was performed. RESULTS: We identified 4867 patients with N3 HNSCC treated with primary surgery or chemoradiotherapy (CRT). Propensity-adjusted median survival was 54.2 and 44.8 months for surgery and CRT, respectively (P = ...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28734109/the-cost-of-oropharyngeal-cancer-in-england-a-retrospective-hospital-data-analysis
#2
Sam T Keeping, Michael J Tempest, Stephanie J Stephens, Stuart M Carroll, Richard Simcock, Terence M Jones, Richard Shaw
OBJECTIVES: To estimate the total costs of treating head and neck cancers, specifically oropharyngeal, laryngeal and oral cavity cancer, in secondary care facilities in England during the period 2006/2007 to 2010/2011. DESIGN: Patient records were extracted from an English hospital database to estimate the number of patients treated for oropharyngeal, laryngeal and oral cavity cancer in England. Identified resource use was linked to published United Kingdom cost estimates to quantify the reimbursement of treatment through the Payment by Results system...
July 22, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28733453/a-novel-functional-splice-variant-of-akt3-defined-by-analysis-of-alternative-splice-expression-in-hpv-positive-oropharyngeal-cancers
#3
Theresa Guo, Akihiro Sakai, Bahman Afsari, Michael Considine, Ludmila Danilova, Alexander V Favorov, Srinivasan Yegnasubramanian, Dylan Z Kelley, Emily Flam, Patrick K Ha, Zubair Khan, Sarah J Wheelan, J Silvio Gutkind, Elana J Fertig, Daria A Gaykalova, Joseph Califano
The incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) has increased more than 200% in the past 20 years. Recent genetic sequencing efforts have elucidated relevant genes in head and neck cancer, but HPV-related tumors have consistently shown few DNA mutations. In this study, we sought to analyze alternative splicing events (ASE) that could alter gene function independent of mutations. To identify ASE unique to HPV-related tumors, RNA sequencing was performed on 46 HPV-positive OPSCC and 25 normal tissue samples...
July 21, 2017: Cancer Research
https://www.readbyqxmd.com/read/28733053/dose-volume-correlates-of-mandibular-osteoradionecrosis-in-oropharynx-cancer-patients-receiving-intensity-modulated-radiotherapy-results-from-a-case-matched-comparison
#4
(no author information available yet)
PURPOSE: To determine dosimetric parameters associated with osteoradionecrosis (ORN) in oropharyngeal cancer (OPC) patients in the IMRT era. MATERIAL AND METHODS: Subsequent to institutional review board approval, we identified ORN in OPC patients treated with IMRT from 2002 to 2013. 1:2 case-control matching was implemented. Mandibular dose-volume histograms (DVH) were extracted. Dosimetric parameters were compared using non-parametric stats. Recursive partitioning analysis (RPA) was done to identify DVH correlates of ORN...
July 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28732044/the-prognostic-impact-of-human-papillomavirus-status-following-treatment-failure-in-oropharyngeal-cancer
#5
Eesha Dave, Umut Ozbek, Vishal Gupta, Eric Genden, Brett Miles, Marita Teng, Marshall Posner, Krzysztof Misiukiewicz, Richard L Bakst
INTRODUCTION: Despite the human papillomavirus conferring a better prognosis in the primary treatment setting, the prognostic impact of viral status after treatment failure in oropharyngeal squamous cell carcinoma patients is poorly understood. METHODS: We retrospectively identified 33 oropharyngeal squamous cell carcinoma (OPC) patients with local and/or distant disease recurrence post-treatment, and looked at metastatic patterns, time to failure and survival patterns by HPV status...
2017: PloS One
https://www.readbyqxmd.com/read/28731497/the-effect-of-frailty-on-short-term-outcomes-after-head-and-neck-cancer-surgery
#6
Carrie L Nieman, Karen T Pitman, Anthony P Tufaro, David W Eisele, Kevin D Frick, Christine G Gourin
OBJECTIVE: To determine the relationship between frailty and comorbidity, in-hospital mortality, postoperative complications, length of hospital stay (LOS), and costs in head and neck cancer (HNCA) surgery. STUDY DESIGN: Cross-sectional analysis. METHODS: Discharge data from the Nationwide Inpatient Sample for 159,301 patients who underwent ablative surgery for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2001 to 2010 was analyzed using cross-tabulations and multivariate regression modeling...
July 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28722666/tumor-pd-l1-status-and-cd8-tumor-infiltrating-t-cells-markers-of-improved-prognosis-in-oropharyngeal-cancer
#7
Astrid De Meulenaere, Tijl Vermassen, Sandrine Aspeslagh, Philippe Deron, Fréderic Duprez, Debby Laukens, Jo Van Dorpe, Liesbeth Ferdinande, Sylvie Rottey
INTRODUCTION: The aim of this study was to evaluate the expression of PD-L1 in oropharyngeal squamous cell carcinoma. Its relation with clinicopathological variables such as amount and type of tumor infiltrating lymphocytes, HPV status and survival was also determined. RESULTS: Positive PD-L1 status for the SP142 clone related with improved overall survival in oropharyngeal squamous cell carcinoma. Tumors heavily infiltrated by tumor infiltrating lymphocytes were also linked with better outcome, and this as well for the total number of tumor infiltrating lymphocytes as for the CD3+ and CD8+ T cell count...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721037/future-trends-and-emerging-issues-for-nanodelivery-systems-in-oral-and-oropharyngeal-cancer
#8
REVIEW
Alexandra Iulia Irimie, Laura Sonea, Ancuta Jurj, Nikolay Mehterov, Alina Andreea Zimta, Liviuta Budisan, Cornelia Braicu, Ioana Berindan-Neagoe
Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28720154/human-papillomavirus-tumour-status-is-not-associated-with-a-positive-depression-screen-for-patients-with-oropharyngeal-cancer
#9
J R Qualliotine, J A Califano, R J Li, D Gold, B Messing, G Lee, P Ha, C Fakhry
BACKGROUND: Several risk factors for depression in patients with oropharyngeal cancer have been determined. However, it is unknown whether human papillomavirus associated oropharyngeal cancer, which has a distinct clinico-demographic profile, modulates this risk. METHODS: A retrospective analysis was conducted of patients with oropharyngeal cancer. These patients had completed a 10-item depression screening questionnaire before receiving treatment for their disease from 2011 to 2014...
July 19, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28718590/-novelties-in-ent-2016
#10
Francis Marchal
These novelties in ENT were selected among more than 15'000 abstracts in the 2016 literature, and dedicated to the practioner Guidelines of the American Academy of ORL will resume the attitude towards chronic otitis media, and reviews of hearing impairment and tinnitus are presented, as well as impact of the pneumoccal vaccine on otitis media. In rhinology, the flora of chronic rhinosinusitis and its non surgical treatments will be discussed, as well as epistaxis and malignant tumor series. 17 Diseases dignanosed only with exhaled air will be also reported...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28718033/a-new-clinical-trial-of-neoadjuvant-chemotherapy-combined-with-transoral-robotic-surgery-and-customized-adjuvant-therapy-for-patients-with-t3-or-t4-oropharyngeal-cancer
#11
Young Min Park, Chan Min Jung, Dongchul Cha, Da Hee Kim, Hye Ryun Kim, Ki Chang Keum, Nam Hoon Cho, Se-Heon Kim
BACKGROUND: A prospective clinical trial of combination neoadjuvant chemotherapy, transoral robotic surgery (TORS), and customized adjuvant therapy for patients with locally advanced oropharyngeal cancer was conducted. METHODS: Between July 2009 and October 2016, 31 patients were enrolled in this clinical trial. RESULTS: The primary lesions were located in the tonsils of 27 patients and in the base of the tongue of 4 patients. Of the 31 patients, 16 (51...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28717958/-the-8th-edition-of-the-ajcc-cancer-staging-manual-updates-in-otorhinolaryngology-head-and-neck-surgery
#12
REVIEW
J Doescher, J A Veit, T K Hoffmann
BACKGROUND: The TNM system is an established tool for classification of solid tumors by means of tumor size and extent, the involvement of local lymph nodes, and the presence of distant metastases. The classification was established in order to visualize prognostic implications and to allow establishment of systematic therapeutic algorithms. Since the beginning of 2017 a revised version of the classification has applied. Particularly the classification of otorhinolaryngologic tumors has been thoroughly revised in the 8th edition, partly on the basis of new prognostically relevant parameters, such as infection with oncogenic human papillomavirus (HPV) subtypes...
July 17, 2017: HNO
https://www.readbyqxmd.com/read/28712533/dose-volume-toxicity-modeling-for-de-intensified-chemo-radiation-therapy-for-hpv-positive-oropharynx-cancer
#13
Panayiotis Mavroidis, Alex Price, David Fried, Mark Kostich, Robert Amdur, William Mendenhall, Chihray Liu, Shiva Das, Lawrence B Marks, Bhishamjit Chera
BACKGROUND AND PURPOSE: The aim is to determine the radiobiological parameters of four popular normal tissue complication probability (NTCP) models that describe the dose-response relations of salivary glands and pharyngeal constrictors to the severity of patient reported xerostomia and dysphagia, respectively 6 and 12months post chemo-radiotherapy, furthermore, to evaluate the goodness-of-fit of the NTCP models for different combinations of glands and constrictors. MATERIAL AND METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study (ClinicalTrials...
July 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28711976/assessment-of-indomethacin-oral-spray-for-the-treatment-of-oropharyngeal-mucositis-induced-pain-during-anticancer-therapy
#14
Kenji Momo, Hiroka Nagaoka, Yoshiyuki Kizawa, Hiroki Bukawa, Shigeru Chiba, Yukinao Kohda, Masato Homma
PURPOSE: The efficacy and safety of indomethacin (IM) oral spray (OS) as a pain control therapy for oropharyngeal mucositis due to anticancer chemo- and radiotherapy were assessed in patients with head and neck carcinomas and haematological tumours. METHOD: We observed 35 patients (male/female, 20/15; 53 ± 17 years) with oropharyngeal mucositis who were treated with IM-OS preparation for pain relief at University of Tsukuba Hospital, Japan. Analgesic effects were assessed using the six-grade face scale for pain in 28 patients at the start of IM oral spray treatment...
July 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28703163/oral-and-oropharyngeal-cancer-and-the-role-of-sexual-behaviour-a-systematic-review
#15
(no author information available yet)
Limited and inconsistent evidence that sexual behaviours are a risk factor for orophangeal cancer.
June 9, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28698400/altered-toll-like-receptor-expression-and-function-in-hpv-associated-oropharyngeal-carcinoma
#16
Priscila Lie Tobouti, Robert Bolt, Raghu Radhakrishnan, Suzana Cantanhede Orsini Machado Sousa, Keith D Hunter
Toll-like receptors (TLRs) have been widely investigated due to their importance in the inflammatory response and possible links to tumor promotion/regression and prognosis. In cancers with an infective etiology, such as human papillomavirus (HPV)-associated Oropharyngeal Squamous Cell Carcinoma (OPSCC), TLR responses may be activated and play a role in tumorigenesis. Our aim was to assess the expression of all TLRs in OPSCC cell lines (both HPV+ and HPV-) by qPCR, Western Blot and flow cytometry and assess their response to TLR ligands lipopolysaccharide (LPS), LPS ultra-pure (LPS-UP) and peptidoglycan (PGN) by analyzing IL-8 and IL-6 production...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696004/frequent-loss-of-inositol-polyphosphate-5-phosphatase-in-oropharyngeal-squamous-cell-carcinoma
#17
A B Patel, A R Mangold, C M Costello, T H Nagel, M L Smith, R E Hayden, A Sekulic
There is an incomplete understanding in the pathogenesis of oropharyngeal squamous cell carcinoma (OPSCC) and cancer broadly. It is essential to discover new pathways of normal cell-cycle regulation and oncogenesis. We identified that the loss of inositol polyphosphate-5-phosphatase (INPP5A) may play a role in the development and progression of cutaneous squamous cell carcinoma (SCC).(1) Loss of INPP5A has been previously linked to cancer development and progression.(2) This article is protected by copyright...
July 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28693152/multicenter-research-into-the-quality-of-life-of-patients-with-advanced-oropharyngeal-carcinoma-with-long-term-survival-associated-with-human-papilloma-virus
#18
Giacomo Spinato, Marco Stellin, Giuseppe Azzarello, Deborah Bonazza, Fabrizio Zanconati, Doriano Politi, Salvatore Cocuzza, Paola Di Mauro, Simonetta Ausoni, Giovanni Tonoli, Giulio Costantini, Luigi Maiolino, Roberto Spinato, Maria Cristina Da Mosto, Lorena Baboci, Annarosa Del Mistro, Agostino Serra, Giancarlo Tirelli
The treatment of advanced-stage oropharyngeal squamous cell carcinoma may utilize various modes, including combining surgery with chemoradiotherapy (CTRT), or primary CTRT followed by rescue surgery. In previous literature it has been revealed how patients treated with combined modes report a low quality of life (QoL) and severe consequences following surgery, radiotherapy and chemotherapy, in the short and in the long-term. The decrease in the QoL of patients treated with high-intensity multi-modal strategies highlights the necessity of modifying treatments, particularly for young HPV-positive patients, where an increased survival rate has already been reported...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691358/survival-benefit-of-surgical-approach-for-advanced-oropharyngeal-and-hypopharyngeal-cancer-a-retrospective-analysis
#19
Chih-Tao Cheng, Ching-Yuan Lin, Skye Hung-Chun Cheng, Yi-Ping Lin, Lay-Chin Lim, Nicolas Pennarun, Zhen-Ying Liu, Shyuang-Der Terng
BACKGROUND: Head and neck cancer is increasingly being managed through nonsurgical approaches. Evidence comes from studies that have mainly examined patients with laryngeal cancer. Few studies, with limited sample size, have focused on the comparative outcomes of surgical and nonsurgical approaches in patients with advanced oropharyngeal or hypopharyngeal cancer. METHODS: Using a national cancer database, we identified 1603 and 1512 patients with clinical stage III/IVA oropharyngeal and hypopharyngeal cancer, respectively, treated between 2004 and 2009...
July 10, 2017: Head & Neck
https://www.readbyqxmd.com/read/28691255/impact-of-human-papillomavirus-on-outcome-in-patients-with-oropharyngeal-cancer-treated-with-primary-surgery
#20
Martina A Broglie, Sandro J Stoeckli, Rafael Sauter, Philippe Pasche, Antoine Reinhard, Laurence de Leval, Gerhard F Huber, Thomas F Pezier, Alex Soltermann, Roland Giger, Andreas Arnold, Matthias Dettmer, Andre Arnoux, Martin Müller, Stefan Spreitzer, Florian Lang, Mathieu Lutchmaya, Edouard Stauffer, Vittoria Espeli, Francesco Martucci, Massimo Bongiovanni, Diana Foerbs, Wolfram Jochum
BACKGROUND: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. METHODS: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors...
July 10, 2017: Head & Neck
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