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Oropharyngeal cancer

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https://www.readbyqxmd.com/read/29452716/dental-pulp-status-of-posterior-teeth-in-patients-with-oral-and-oropharyngeal-cancer-treated-with-radiotherapy-1-year-follow-up
#1
Nishtha Gupta, Mandeep S Grewal, Munish Gairola, Stutee Grewal, Parveen Ahlawat
INTRODUCTION: Teeth may react negatively to pulp sensitivity testing in patients who have undergone radiotherapy. The aim of the current investigation was to evaluate the pulp sensibility of posterior teeth at 4, 6, and 12 months in patients who have undergone radiotherapy for oral and oropharyngeal malignancies. METHODS: Seventy-nine patients diagnosed with malignant oral and oropharyngeal cancer undergoing radiotherapy underwent cold thermal pulp sensitivity testing and electric pulp testing of 4 teeth, 1 from each quadrant...
February 13, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29451891/association-of-an-intact-e2-gene-with-higher-hpv-viral-load-higher-viral-oncogene-expression-and-improved-clinical-outcome-in-hpv16-positive-head-and-neck-squamous-cell-carcinoma
#2
Nicole V Anayannis, Nicolas F Schlecht, Miriam Ben-Dayan, Richard V Smith, Thomas J Belbin, Thomas J Ow, Duk M Blakaj, Robert D Burk, Sarah M Leonard, Ciaran B Woodman, Joanna L Parish, Michael B Prystowsky
To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. Expression of HPV16 E6, E7 and E2 transcripts, along with cellular ARF and INK4A, were also assessed by RT-qPCR. Associations between E2 disruption, E2/E6/E7 expression, and clinical outcome were evaluated by Kaplan-Meier analysis for loco-regional recurrence and disease-specific survival...
2018: PloS One
https://www.readbyqxmd.com/read/29451617/trends-in-social-security-benefits-for-oral-and-oropharyngeal-cancer-from-2006-to-2013-in-brazil
#3
Rafael Aiello Bomfim, Andreia Morales Cascaes
OBJECTIVE: to analyze the trends in the concession of social security sick pay for oral and oropharyngeal cancer, from 2006 to 2013, in Brazil. METHODS: time series study using data of workers insured by the Brazilian National Institute of Social Security (INSS); Prais-Winsten generalized linear regressions were used to calculate the annual percentage change (APC). RESULTS: social security benefits for oral and oropharyngeal cancer presented significant increase (APC=9...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29451412/development-and-validation-of-a-radiomic-signature-to-predict-hpv-p16-status-from-standard-ct-imaging-a-multicenter-study
#4
Leijenaar Rth, Bogowicz M, Jochems A, Hoebers Fjp, Frederik Fwr, Huang Sh, Chan B, Waldron Jn, O'Sullivan B, Rietveld D, Leemans Cr, Brakenhoff Rh, Riesterer O, Tanadini-Lang S, Guckenberger M, Ikenberg K, Lambin P
OBJECTIVES: HPV positive oropharyngeal cancer (OPSCC) is biologically and clinically different from HPV negative OPSCC. Here, we evaluate the use of a radiomic approach to identify the HPV status of OPSCC. METHODS: Four independent cohorts, totaling 778 OPSCC patients with HPV determined by p16 were collected. We randomly assigned 80% of all data for model training (N=628) and 20% for validation (N=150). On the pre-treatment CT images, 902 radiomic features were calculated from the gross tumor volume (GTV)...
February 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29447088/increasing-incidence-and-survival-of-head-and-neck-cancers-in-denmark-a-nation-wide-study-from-1980-to-2014
#5
Kathrine Kronberg Jakobsen, Christian Grønhøj, David Hebbelstrup Jensen, Kirstine Kim Schmidt Karnov, Tina Klitmøller Agander, Lena Specht, Christian von Buchwald
BACKGROUND: The purpose of the study was to determine trends in age-adjusted incidence rates (AAIR) and survival probability in head and neck cancers (HNCs) in the Danish population from 1980 to 2014. MATERIAL AND METHODS: All patients registered with HNC in the nationwide Danish Cancer Registry from 1980 to 2014 were included. We evaluated the AAIR per 100,000 and the average annual percent change (AAPC). The relative survival probability at 5 years was calculated in relation to gender, anatomical location and histology, and we constructed age-period-cohort models of incidence...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29446476/the-role-of-human-papillomavirus-in-laryngeal-cancer-in-southern-china
#6
Eddy Wh Lam, Michael Mh Chan, Cynthia Kc Wai, Chi Man Ngai, Zigui Chen, Martin Cs Wong, Apple Cm Yeung, Joanna Hm Tong, Amy Bw Chan, K F To, Paul Ks Chan
Objective Delineate the role of human papillomavirus (HPV) in laryngeal cancer in Southern Chinese. Study Design A retrospective cross-sectional study. Setting A major otorhinolaryngology referral center in Hong Kong. Subjects and Methods Eighty-five Chinese patients with histology-confirmed laryngeal squamous cell carcinoma (LSCC) diagnosed between 2005 and 2010 were examined for the status of HPV by PCR, and the expression of p16 and p53 by immunohistochemistry. The HPV, p16 and p53 findings were correlated with clinicopathological features, recurrence and 5-year survival...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29443623/calprotectin-and-the-initiation-and-progression-of-head-and-neck-cancer
#7
P P Argyris, Z M Slama, K F Ross, A Khammanivong, M C Herzberg
Calprotectin (S100A8/A9), a heterodimeric complex of calcium-binding proteins S100A8 and S100A9, is encoded by genes mapping to the chromosomal locus 1q21.3 of the epidermal differentiation complex. Whereas extracellular calprotectin shows proinflammatory and antimicrobial properties by signaling through RAGE and TLR4, intracytoplasmic S100A8/A9 appears to be important for cellular development, maintenance, and survival. S100A8/A9 is constitutively expressed in myeloid cells and the stratified mucosal epithelia lining the oropharyngeal and genitourinary mucosae...
February 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29441569/epidemiologic-associations-of-hpv-positive-oropharyngeal-cancer-and-pre-cancerous-cervical-lesions
#8
M M Rietbergen, A A J D van Bokhoven, B I Lissenberg-Witte, D A M Heideman, C R Leemans, R H Brakenhoff, E Bloemena
PURPOSE: Human papillomavirus (HPV)- induced oropharyngeal squamous cell carcinoma (OPSCC) is still increasing worldwide. We aimed to investigate if the HPV-prevalence of OPSCC in the Netherlands is rising as well, especially in female patients. In addition, we evaluated the association between HPV-positive OPSCC and suspicious Pap results of the cervix in these female patients. PATIENTS AND METHODS: Patients with OPSCC treated in the period 2000-2015 at the VU University Medical Center Amsterdam, were included (n=926)...
February 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29434933/pd-l1-expression-is-associated-with-p16-ink4a-expression-in-non-oropharyngeal-head-and-neck-squamous-cell-carcinoma
#9
San-Chi Chen, Peter Mu-Hsin Chang, Hsiao-Jung Wang, Shyh-Kuan Tai, Pen-Yuan Chu, Muh-Hwa Yang
PD-L1 expression is critical in helping tumor cells evade the immune system. However, the level of PD-L1 expression in non-oropharyngeal head and neck squamous cell carcinoma (non-OPHNSCC) and its association with patient prognosis remains unclear. A retrospective clinicopathological analysis was performed on 106 patients with non-OPHNSCC diagnosed between 2007 and 2014. In the current study, tissue arrays from paraffin-embedded non-OPHNSCC samples obtained from patients were constructed, and PD-L1 and p16 INK4A expression were determined using immunohistochemistry...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29428959/feasibility-of-salvage-selective-neck-dissection-after-primary-irradiation-of-pharyngeal-and-laryngeal-carcinoma
#10
Norhafiza Mat Lazim, Kahairi Abdullah, Baris Karakullukcu, Ing Bing Tan
INTRODUCTION: The concept of neck dissection (ND) in the management armamentarium of head and neck squamous cell carcinoma has evolved throughout the years. Nowadays, ND becomes more functional. METHODOLOGY: A retrospective study of 865 patients was performed at Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital to investigate the feasibility of selective ND (SND). All patients with squamous cell carcinoma of the pharynx and larynx who received primary radiation and underwent salvage ND were included in the study...
February 9, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29427129/trends-in-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-incidence-vermont-1999-2013
#11
Adepitan A Owosho, Rashidah Wiley, Tessie Stansbury, Semiu O Gbadamosi, Jon S Ryder
This study examines trends in age-adjusted incidence rates of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) in comparison to oral cavity proper squamous cell carcinoma (OSCC) in the population of Vermont from 1999 to 2013. Data on cases of oral and pharynx cancers diagnosed in Vermont between 1999 and 2013 were obtained from the Vermont cancer registry. The age-adjusted incidence rates and annual percentage change of HPV-related OPSCC and OSCC were calculated using Joinpoint trend analysis...
February 9, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29422018/assessing-the-performance-of-a-loop-mediated-isothermal-amplification-lamp-assay-for-the-detection-and-subtyping-of-high-risk-suptypes-of-human-papilloma-virus-hpv-for-oropharyngeal-squamous-cell-carcinoma-opscc-without-dna-purification
#12
Mitchell G Rohatensky, Devon M Livingstone, Paul Mintchev, Heather K Barnes, Steven C Nakoneshny, Douglas J Demetrick, Joseph C Dort, Guido van Marle
BACKGROUND: Oropharyngeal Squamous Cell Carcinoma (OPSCC) is increasing in incidence despite a decline in traditional risk factors. Human Papilloma Virus (HPV), specifically subtypes 16, 18, 31 and 35, has been implicated as the high-risk etiologic agent. HPV positive cancers have a significantly better prognosis than HPV negative cancers of comparable stage, and may benefit from different treatment regimens. Currently, HPV related carcinogenesis is established indirectly through Immunohistochemistry (IHC) staining for p16, a tumour suppressor gene, or polymerase chain reaction (PCR) that directly tests for HPV DNA in biopsied tissue...
February 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29419940/development-and-evaluation-of-a-holistic-surgical-head-and-neck-cancer-post-treatment-follow-up-clinic-using-touchscreen-technology-feasibility-study
#13
C J Semple, D Lannon, E Qudairat, E McCaughan, R McCormac
The efficacy of traditional follow-up care is being challenged, as cancer survivors' supportive and psychological needs are often neither identified, nor addressed. This study's aim was to develop a holistic surgical follow-up clinic for oral and oropharyngeal cancer patients were participants completed a disease-specific health-related quality of life tool (UWQOLv4) and item prompt list (Patient Concern Inventory) on a touchscreen computer. Information generated was used to focus the consultation on patient's identified needs and concerns...
February 8, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29416610/altered-toll-like-receptor-expression-and-function-in-hpv-associated-oropharyngeal-carcinoma
#14
Priscila Lie Tobouti, Robert Bolt, Raghu Radhakrishnan, Suzana Cantanhede Orsini Machado de Sousa, Keith D Hunter
Toll-like receptors (TLRs) have been widely investigated due to their importance in the inflammatory response and possible links to tumor promotion/regression and prognosis. In cancers with an infective etiology, such as human papillomavirus (HPV)-associated Oropharyngeal Squamous Cell Carcinoma (OPSCC), TLR responses may be activated and play a role in tumorigenesis. Our aim was to assess the expression of all TLRs in OPSCC cell lines (both HPV+ and HPV-) by qPCR, Western Blot and flow cytometry and assess their response to TLR ligands lipopolysaccharide (LPS), LPS ultra-pure (LPS-UP) and peptidoglycan (PGN) by analyzing IL-8 and IL-6 production...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29411154/modified-biweekly-cisplatin-docetaxel-plus-cetuximab-tpex-as-first-line-treatment-for-patients-with-recurrent-metastatic-head-and-neck-cancer
#15
Hannah Fuchs, Johannes Pammer, Christoph Minichsdorfer, Doris Posch, Gabriela Kornek, Marie-Bernadette Aretin, Thorsten Fuereder
Three weekly high-dose chemotherapy regimens in combination with weekly cetuximab are the treatment of choice for patients with recurrent/metastatic (R/M) head and neck squamous cell carcinoma (SCCHN), although the majority of patients suffer from severe side effects. Thus, we investigated the efficacy and safety of an alternative, more convenient and less toxic biweekly modified cisplatin, docetaxel plus cetuximab (TPEx) regimen in this retrospective analysis. Thirty-eight patients receiving off-protocol cisplatin (50 mg/m2) in combination with docetaxel (50 mg/m2) plus cetuximab (500 mg/m2) every other week were included...
February 7, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29406335/fish-shellfish-intake-and-the-risk-of-head-and-neck-cancer
#16
Kathleen M McClain, Patrick T Bradshaw, Nikhil K Khankari, Marilie D Gammon, Andrew F Olshan
Fish intake and other dietary sources of omega-3 fatty acids have been shown to be associated with a reduced risk for some cancers. Although previous studies of head and neck cancer have reported associations with different dietary factors, including reduced risks for fruits and vegetables and putatively healthy dietary patterns, associations specific to fish intake are unclear. This study investigated the association between fish/shellfish intake and risk of squamous cell carcinoma of the head and neck (SCCHN) using data from the Carolina Head and Neck Cancer Epidemiology Study, a population-based case-control study conducted in 46 North Carolina counties with cases recruited from 2002 through 2006...
February 5, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29397249/comparison-of-xerostomia-incidence-after-three-dimensional-conformal-radiation-therapy-and-contralateral-superficial-lobe-parotid-sparing-intensity-modulated-radiotherapy-for-oropharyngeal-and-hypopharyngeal-cancer
#17
Terufumi Kawamoto, Keiji Nihei, Yujiro Nakajima, Satoshi Kito, Keisuke Sasai, Katsuyuki Karasawa
OBJECTIVE: In the treatment of head-neck cancer, parotid-sparing intensity-modulated radiotherapy (IMRT) could reduce the incidence of xerostomia. When the parotid glands cannot be sufficiently spared because of the widespread tumor, contralateral superficial lobe parotid-sparing (CSLPS)-IMRT could be used to reduce marginal recurrence, however the success of this approach remains to be determined. The primary purpose of this study was to compare the incidence of xerostomia between three-dimensional conformal radiotherapy (3D-CRT) and CSLPS-IMRT for oropharyngeal and hypopharyngeal cancer...
January 31, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29395630/failure-of-further-validation-for-survival-nomograms-in-oropharyngeal-cancer-issues-and-challenges
#18
Paolo Bossi, Rosalba Miceli, Roberta Granata, Simona Naimo, Gabriele Infante, Laura Deborah Locati, Nicola Alessandro Iacovelli, Carlo Fallai, Lisa Licitra, Ester Orlandi
PURPOSE: To retrospectively test 2 nomograms recently validated as prognostic tools for patients with oropharyngeal cancer treated with curative radiation-based therapy, in 184 consecutive subjects treated from April 2004 to January 2016. PATIENT AND METHODS: Complete information regarding disease, survival status, and nomogram covariates was retrieved for 174 patients, with a median follow-up of 51 months. Calibration of the nomograms was obtained by evaluating the ability to accurately predict the absolute risk level; discriminative ability estimated by the Harrell C statistic was tested by assessing the ability of the nomograms to rank the patients from low risk to high risk...
December 28, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29394646/-two-cases-of-non-occlusive-mesenteric-ischemia-that-developed-after-chemotherapy
#19
Takahiro Wada, Kenji Katsumata, Hiroshi Kuwahara, Takaaki Matsudo, Yusuke Murakoshi, Masatoshi Shigoka, Masanobu Enomoto, Tetsuo Ishizaki, Kazuhiko Kasuya, Akihiko Tsuchida
Non-occlusive mesenteric ischemia(NOMI)causes intestinal necrosis due to irreversible ischemia of the intestinal tract despite the absence of organic obstruction in the mesenteric blood vessels. The disease has extremely poor prognosis. We encountered 2 cases of NOMI hypothesized to have developed after chemotherapy; thus, we report these cases considering the available literature. Case 1: A7 9-year-old man. The patient complained of abdominal pain during the first week after introducing docetaxel for local recurrence of prostate cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394609/-a-contrivance-for-closure-and-dressing-of-orocutaneous-fistula-developed-in-advanced-oral-cancer
#20
Yoshiki Nariai, Junichi Akutsu, Satoe Okuma, Sho Odawara, Takahiro Kanno, Joji Sekine
Orocutaneous fistula sometimes occurs in locallyadvanced unresectable or recurrent oral squamous cell carcinoma. The developed orocutaneous fistula results in constant leakage of saliva, ingested foods and liquids and decline in patients' quality of life(QOL). A 47-year-old Japanese man had received treatment for tongue carcinoma. At the routine follow-up, a cystic lesion in the right submandibular region was detected. Biopsyof the specimen of the cystic lesion revealed squamous cell carcinoma. After chemotherapy, an orocutaneous fistula between the right oropharyngeal and the right submandibular region developed and graduallyincreased...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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