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https://www.readbyqxmd.com/read/29664916/is-periodontitis-a-risk-indicator-for-cancer-a-meta-analysis
#1
Stefano Corbella, Paolo Veronesi, Viviana Galimberti, Roberto Weinstein, Massimo Del Fabbro, Luca Francetti
BACKGROUND: The aim of the present systematic review was to evaluate the hypothesis of an association between periodontitis and the development of cancer. METHODS: Two reviewers independently screened electronic and manual sources for pertinent articles. Primary outcome measures were the occurrence of neoplasm diagnosis in exposed and non-exposed groups, reported to evaluate association between cancer and periodontitis. RESULTS: Of the 490 initially retrieved papers 10 were included in the qualitative synthesis and eight in the quantitative synthesis; the eight papers covered six studies...
2018: PloS One
https://www.readbyqxmd.com/read/29664911/hpv-relatedness-definitions-for-classifying-hpv-related-oropharyngeal-cancer-patient-do-impact-on-tnm-classification-and-patients-survival
#2
Miren Taberna, Marisa Mena, Sara Tous, Miquel Angel Pavón, Marc Oliva, Xavier León, Jacinto Garcia, Marta Guix, Rafael Hijano, Teresa Bonfill, Antón Aguilà, Laia Alemany, Ricard Mesía
BACKGROUND: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted for the 8th edition AJCC TNM (ICON-S model). However, it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. MATERIAL AND METHODS: The aim of this study was to compare different staging system models proposed for HPV-related OPC patients: 7th edition AJCC TNM, RPA stage with non-anatomic factors (Princess Margaret), RPA with N categories for nasopharyngeal cancer (MD-Anderson) and AHR-new (ICON-S), according to different HPV-relatedness definitions: HPV-DNA detection plus an additional positive marker (p16INK4a or HPV-mRNA), p16INK4a positivity alone or the combination of HPV-DNA/p16INK4a positivity as diagnostic tests...
2018: PloS One
https://www.readbyqxmd.com/read/29663357/hpv16-increases-the-number-of-migratory-cancer-stem-cells-and-modulates-their-mirna-expression-profile-in-oropharyngeal-cancer
#3
Martin Hufbauer, Margaret Maltseva, Jeannine Meinrath, Axel Lechner, Dirk Beutner, Christian U Huebbers, Baki Akgül
Human papillomavirus type 16 (HPV16) is a major risk for development of oropharyngeal squamous-cell-carcinoma (OPSCC). Although HPV+ OPSCC metastasize faster than HPV- tumors, they have a better prognosis. The molecular and cellular alterations underlying this pathobiology of HPV+ OPSCC remain elusive. In this study we examined whether expression of HPV16-E6E7 targets the number of migratory and stationary cancer-stem-cells (CSC). Furthermore, we wanted to elucidate if aberrantly expressed miRNAs in migratory CSC may be responsible for progression of OPSCCs and whether they may serve as potential novel biomarkers for increased potential of metastasis...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29663347/a-tgf-%C3%AE-1-genetic-variant-at-the-mirna187-binding-site-significantly-modifies-risk-of-hpv16-associated-oropharyngeal-cancer
#4
Ye Tao, Erich M Sturgis, Zhigang Huang, Yan Sun, Kristina R Dahlstrom, Qingyi Wei, Guojun Li
TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that TGF-β1rs1982073 polymorphism at the miRNA-187 binding site combined with HPV16 L1 seropositivity may have a joint effect on OSCC susceptibility...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29659751/a-randomized-placebo-controlled-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-adults-age-27-years-or-older-aids-clinical-trials-group-protocol-a5298
#5
Timothy J Wilkin, Huichao Chen, Michelle S Cespedes, Jorge T Leon-Cruz, Catherine Godfrey, Elizabeth Y Chiao, Barbara Bastow, Jennifer Webster-Cyriaque, Qinghua Feng, Joan Dragavon, Robert W Coombs, Rachel M Presti, Alfred Saah, Ross D Cranston
Background: Adults living with HIV are at increased risk for anal and oropharyngeal cancer caused by human papillomavirus (HPV). The efficacy of HPV vaccines in this population is unknown. Methods: Phase 3, double-blind, randomized controlled trial. We assigned HIV-infected adults age 27 or older to the quadrivalent HPV (Types 6, 11, 16, 18) vaccine or placebo (1:1) stratified by sex and presence of anal high-grade squamous intraepithelial lesions on biopsy (bHSIL)...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29650896/-the-combination-of-molecular-targeted-agents-with-radiotherapy-in-head-and-neck-cancer
#6
Mitsuhiro Furuta, Tomoya Yokota
Concurrent cisplatin based chemoradiotherapy(CRT)is the standard of care for patients with locoregionally advanced squamous cell carcinoma of the head and neck(LA-SCCHN). Based on the Bonner trial showing the superiority of cetuximab plus radiotherapy to radiotherapy alone, cetuximab based bioradiotherapy(BRT)is considered as an alternative for patients with LA-SCCHN. However, the non-inferiority of BRT compared to CRT has not yet been demonstrated. Furthermore, severe mucositis and dermatitis induced by BRT cannot be neglected...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650421/financial-outcomes-of-transoral-robotic-surgery-a-narrative-review
#7
REVIEW
Sammy Othman, Brian J McKinnon
OBJECTIVE: To determine the current cost impact and financial outcomes of transoral robotic surgery in Otolaryngology. DATA SOURCES: A narrative review of the literature with a defined search strategy using Pubmed, MEDLINE, CINAHL, and Web of Science. REVIEW METHODS: Using keywords ENT or otolaryngology, cost or economic, transoral robotic surgery or TORs, searches were performed in Pubmed, MEDLINE, CINAHL, and Web of Science and reviewed by the authors for inclusion and analysis...
April 3, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29645080/risk-of-oral-tongue-cancer-among-immunocompromised-transplant-recipients-and-human-immunodeficiency-virus-infected-individuals-in-the-united-states
#8
Joseph E Tota, Eric A Engels, Margaret M Madeleine, Christina A Clarke, Charles F Lynch, Ana P Ortiz, Brenda Y Hernandez, Anil K Chaturvedi
BACKGROUND: Oral tongue cancer incidence has increased among whites in the United States; however, the cause remains unknown. If an infectious agent is implicated, then elevated risk would be expected among immunosuppressed individuals. METHODS: By using population-based registry linkage information from the US Transplant Cancer Match and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) Cancer Match studies, the authors examined the risk of oral tongue squamous cell carcinoma (SCC) among immunocompromised transplantation recipients and HIV-infected individuals...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29624559/risk-factors-for-oral-hpv-infection-among-young-men-who-have-sex-with-men-2-cities-united-states-2012-2014
#9
Sara E Oliver, Pamina Gorbach, Beau Gratzer, Martin Steinau, Tom Collins, Adam Parrish, Peter R Kerndt, Richard Crosby, Elizabeth R Unger, Lauri E Markowitz, Elissa Meites
BACKGROUND: Men who have sex with men (MSM) are at risk for cancers attributable to human papillomavirus (HPV), including oropharyngeal cancer. HPV vaccination is recommended for U.S. MSM through age 26 years. Oral HPV infection is associated with oropharyngeal cancer. We determined oral HPV prevalence and risk factors among young MSM. METHODS: The Young Men's HPV study enrolled MSM aged 18-26 years from clinics in Chicago and Los Angeles during 2012-2014. Participants self-reported demographics, sexual behaviors, vaccination and HIV status...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29623202/role-of-high-risk-human-papillomavirus-in-the-etiology-of-oral-and-oropharyngeal-cancers-in-thailand-a-case-control-study
#10
Adit Chotipanich, Surattaya Siriarechakul, On-Ong Mungkung
Background: Among developing countries, Thailand shows no increase in the incidence of human papillomavirus-driven oropharyngeal cancer. The causal role of human papillomavirus infection in this pathology has not been researched thoroughly. Methods: A hospital-based, case-control study was performed which included 104 patients with newly diagnosed oral and oropharyngeal squamous cell carcinomas and 104 individuals without cancer. The Cervista high-risk human papillomavirus and 16/18 assays were used to detect human papillomavirus...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29610959/poor-oral-intake-causes-enteral-nutrition-dependency-after-concomitant-chemoradiotherapy-for-pharyngeal-cancers
#11
Ryo Ishii, Kengo Kato, Takenori Ogawa, Takeshi Sato, Ayako Nakanome, Akira Ohkoshi, Ai Kawamoto-Hirano, Masayuki Shirakura, Hiroshi Hidaka, Yukio Katori
PURPOSE: To identify precipitating factors responsible for enteral nutrition (EN) dependency after concomitant chemoradiotherapy (CCRT) of head and neck cancers and to examine their statistical correlations. METHODS: Factors related to feeding condition, nutritional status, disease, and treatment of 26 oropharyngeal and hypopharyngeal cancer patients who received definitive CCRT were retrospectively investigated by examining their medical records. The days of no oral intake (NOI) during hospitalization and the months using enteral nutrition after CCRT were counted as representing the feeding condition, and the changes in body weight (BW) were examined as reflecting nutritional status...
April 2, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29607447/oropharyngeal-dysphagia-evaluation-tools-in-adults-with-solid-malignancies-outside-the-head-and-neck-and-upper-gi-tract-a-systematic-review
#12
REVIEW
Ciarán Kenny, Órla Gilheaney, Declan Walsh, Julie Regan
Dysphagia is often associated with head and neck and upper gastrointestinal (GI) tract cancers. Evidence suggests that those with solid malignancies in other primary sites may also have swallowing difficulties. Timely and accurate identification of dysphagia is important given the impact it has on hydration, medical treatment, nutrition, prognosis, and quality of life. A systematic review was conducted to identify swallow screening, evaluation, and quality of life tools for those with solid malignancies outside the head and neck and upper GI tract...
April 2, 2018: Dysphagia
https://www.readbyqxmd.com/read/29603728/distinct-profiles-of-tert-promoter-mutations-and-telomerase-expression-in-head-and-neck-cancer-and-cervical-carcinoma
#13
Clorinda Annunziata, Francesca Pezzuto, Stefano Greggi, Franco Ionna, Simona Losito, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
Two recurrent mutations (-124 G>A and -146 G>A) in the core promoter region of the human telomerase reverse transcriptase (TERT) gene create consensus binding sites for ETS transcription factors and cause increased TERT expression in several tumour types. We analyzed TERT promoter mutations and TERT mRNA levels in head and neck cancer, cervical carcinoma and cervical intraepithelial neoplasia (CIN) as well as in C-4I, CaSki, HeLa and SiHa cervical cell lines. Nucleotide sequence analysis of TERT promoter region showed that 33...
March 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29602860/protocol-for-the-trismus-trial-therabite-versus-wooden-spatula-in-the-amelioration-of-trismus-in-patients-with-head-and-neck-cancer-randomised-pilot-study
#14
Rana Lee, Alex Molassiotis, Simon N Rogers, Rhiannon Tudor Edwards, David Ryder, Nick Slevin
INTRODUCTION: Patients can develop trismus from their head and neck cancer or as a result of treatment. Trismus affects the jaw muscles and makes mouth opening difficult. To potentially combat trismus, patients could undertake proactive jaw stretching exercises prior to, during and after radiotherapy, although currently these are not the standard of care. METHODS AND ANALYSIS: This is a randomised, open-label, controlled, two-centre feasibility study, to assess the objective and subjective effectiveness and cost-effectiveness of therabite use compared with wooden spatula in ameliorating trismus in patients treated for stage 3 and 4 oral and oropharyngeal cancer, managed either by primary surgery followed by (chemo)radiotherapy or primary (chemo)radiotherapy...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29602636/oropharyngeal-candidiasis-in-head-and-neck-cancer-patients-in-iran-species-identification-antifungal-susceptibility-and-pathogenic-characterization
#15
Z Jahanshiri, S Manifar, H Moosa, F Asghari-Paskiabi, H Mahmoodzadeh, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
OBJECTIVE: Oropharyngeal candidiasis (OPC) is the most frequent opportunistic fungal infection in head and neck cancer patients. This study was done to identify the Candida species, which cause OPC, and to evaluate their antifungal susceptibility pattern and pathogenic characteristics in Iranian head and neck cancer patients treated by radiotherapy. MATERIAL AND METHODS: The oral clinical samples were determined by culturing on CHROMagar, carbohydrate assimilation and ITS sequencing methods...
March 27, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29601503/the-immunomodulatory-capacity-of-an-epstein-barr-virus-abortive-lytic-cycle-potential-contribution-to-viral-tumorigenesis
#16
REVIEW
Abigail Morales-Sánchez, Ezequiel M Fuentes-Panana
Epstein-Barr virus (EBV) is characterized by a bipartite life cycle in which latent and lytic stages are alternated. Latency is compatible with long-lasting persistency within the infected host, while lytic expression, preferentially found in oropharyngeal epithelial tissue, is thought to favor host-to-host viral dissemination. The clinical importance of EBV relates to its association with cancer, which we think is mainly a consequence of the latency/persistency mechanisms. However, studies in murine models of tumorigenesis/lymphomagenesis indicate that the lytic cycle also contributes to cancer formation...
March 30, 2018: Cancers
https://www.readbyqxmd.com/read/29599172/submandibular-gland-transfer-a-potential-imaging-pitfall
#17
X Wu, S S Yom, P K Ha, C M Heaton, C M Glastonbury
BACKGROUND AND PURPOSE: The Seikaly and Jha submandibular gland transfer surgery is performed to facilitate gland shielding during radiation therapy for head and neck tumors to circumvent radiation-induced xerostomia. It results in an asymmetric postsurgical appearance of the submandibular and submental spaces. Our purpose was to characterize the morphologic and enhancement characteristics of the transferred submandibular gland and identify potential pitfalls in postoperative radiologic interpretation...
March 29, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29598954/clinical-outcomes-and-prognostic-factors-in-cisplatin-versus-cetuximab-chemoradiation-for-locally-advanced-p16-positive-oropharyngeal-carcinoma
#18
Christian L Barney, Steve Walston, Pedro Zamora, Erin H Healy, Nicole Nolan, Virginia M Diavolitsis, Anterpreet Neki, Robert Rupert, Panos Savvides, Amit Agrawal, Matthew Old, Enver Ozer, Ricardo Carrau, Stephen Kang, James Rocco, Theodoros Teknos, John C Grecula, Jessica Wobb, Darrion Mitchell, Dukagjin Blakaj, Aashish D Bhatt
OBJECTIVES: Randomized trials evaluating cisplatin versus cetuximab chemoradiation (CRT) for p16+ oropharyngeal cancer (OPC) have yet to report preliminary data. Meanwhile, as a preemptive step toward morbidity reduction, the off-trial use of cetuximab in p16+ patients is increasing, even in those who could potentially tolerate cisplatin. The purpose of this study was to compare the efficacy of cisplatin versus cetuximab CRT in the treatment of p16+ OPC and to identify prognostic factors and predictors of tumor response...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29598952/upfront-surgery-versus-definitive-chemoradiotherapy-in-patients-with-human-papillomavirus-associated-oropharyngeal-squamous-cell-cancer
#19
Jacqueline R Kelly, Henry S Park, Yi An, Wendell G Yarbrough, Joseph N Contessa, Roy Decker, Saral Mehra, Benjamin L Judson, Barbara Burtness, Zain Husain
OBJECTIVES: Currently, human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-A OPC) is managed with either primary surgery or definitive chemoradiotherapy (CRT), despite the lack of supporting randomized prospective data. We therefore assessed the outcomes of each treatment strategy using the National Cancer Database (NCDB). METHODS: The NCDB was used to identify patients diagnosed with cT1 N2a-2b or cT2 N1-2b HPV-A OPC from 2010 to 2013 who underwent treatment with primary surgery or CRT...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594246/surgery-vs-primary-radiotherapy-in-early-stage-oropharyngeal-cancer
#20
Catia Pedro, Beatriz Mira, Pedro Silva, Eduardo Netto, Rute Pocinho, António Mota, Miguel Labareda, Miguel Magalhães, Susana Esteves, Filomena Santos
Background: Early-stage oropharyngeal squamous cell carcinoma (OPSCC) can currently be treated by surgical resection or definitive radiotherapy (RT). The aim of this study is to review the outcomes of early-stage OPSCC submitted to surgery or primary RT. Preliminary results have shown similar overall survival (OS) and locoregional recurrence-free survival (LRFS). Material/Methods: Retrospective study of patients with cT1-T2 cN0-N1 OPSCC, diagnosed between January 2009 and December 2014, treated with surgery or primary RT...
February 2018: Clinical and Translational Radiation Oncology
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