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Oropharyngeal cancer

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https://www.readbyqxmd.com/read/28643737/changes-in-pharyngeal-constrictor-volumes-during-head-and-neck-radiation-therapy-implications-for-dose-delivery
#1
Akila Kumarasiri, Chang Liu, Mona Kamal, Correen Fraser, Stephen Brown, Indrin J Chetty, Jinkoo Kim, Farzan Siddiqui
OBJECTIVE: The objective of this study was to evaluate the anatomical changes and associated dosimetric consequences to pharyngeal constrictor muscles (PCMs) that occur during head and neck (H and N) radiotherapy (RT). MATERIALS AND METHODS: A cohort of 13 oropharyngeal cancer patients with daily cone beam computed tomography (CBCT) was retrospectively studied. On every 5th CBCT image, PCM was manually delineated by a radiation oncologist. The anterior-posterior PCM thickness was measured at the midline level of C3 vertebral body...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28640546/treatment-at-high-volume-facilities-and-academic-centers-is-independently-associated-with-improved-survival-in-patients-with-locally-advanced-head-and-neck-cancer
#2
John M David, Allen S Ho, Michael Luu, Emi J Yoshida, Sungjin Kim, Alain C Mita, Kevin S Scher, Stephen L Shiao, Mourad Tighiouart, Zachary S Zumsteg
BACKGROUND: The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes. METHODS: The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive squamous cell carcinomas of the oropharynx, larynx, and hypopharynx and were undergoing definitive radiotherapy...
June 22, 2017: Cancer
https://www.readbyqxmd.com/read/28638410/low-survival-rates-of-oral-and-oropharyngeal-squamous-cell-carcinoma
#3
Anna Carolina Omena Vasconcellos Le Campion, Camila Maria Beder Ribeiro, Ronir Raggio Luiz, Francisco Feliciano da Silva Júnior, Herbert Charles Silva Barros, Karine de Cássia Batista Dos Santos, Stefania Jeronimo Ferreira, Lucio Souza Gonçalves, Sonia Maria Soares Ferreira
AIM: To assess the epidemiological and clinical factors that influence the prognosis of oral and oropharyngeal squamous cell carcinoma (SCC). METHODS: One hundred and twenty-one cases of oral and oropharyngeal SCC were selected. The survival curves for each variable were estimated using the Kaplan-Meier method. The Cox regression model was applied to assess the effect of the variables on survival. RESULTS: Cancers at an advanced stage were observed in 103 patients (85...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28633362/human-papillomavirus-related-oropharyngeal-cancer
#4
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía
High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28633075/elective-unilateral-nodal-irradiation-in-head-and-neck-squamous-cell-carcinoma-a-paradigm-shift
#5
A Al-Mamgani, M Verheij, M W M van den Brekel
There is a long-standing convention to irradiate the great majority of head and neck squamous cell carcinoma (HNSCC) electively to both sides of the neck, to reduce the theoretically increased risk of contralateral regional failure (cRF). With the currently available diagnostic imaging techniques this treatment paradigm means, in our opinion, an overtreatment in considerable proportion of these patients. From all the published studies (n = 11, with 1116 patients treated in total), the incidence of cRF in patients with oropharyngeal cancer treated to one side of the neck is 2...
June 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28632936/peritumoral-cuffing-by-t-cell-tumor-infiltrating-lymphocytes-distinguishes-hpv-related-oropharyngeal-squamous-cell-carcinoma-from-oral-cavity-squamous-cell-carcinoma
#6
Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant
BACKGROUND: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors. METHODS: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative)...
June 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28627802/the-length-of-patient-and-primary-care-time-interval-in-the-pathways-to-treatment-in-symptomatic-oral-cancer-a-quantitative-systematic-review
#7
P Varela-Centelles, J Seoane, J L Lopez-Cedrun, J Fernandez-Sanroman, J M García-Martin, B Takkouche, P Alvarez-Novoa, J M Seoane-Romero
BACKGROUND: Only a 5% improvement in overall survival to oral cancer has been achieved in the last 20 years. Almost half of all oral carcinomas are diagnosed at advanced stages essentially due to delay in the diagnosis. Objective of the review: to examine the relative length of the patient and primary care intervals in symptomatic oral cancer. TYPE OF REVIEW: Quantitative systematic review. SEARCH STRATEGY: ((oral cancer OR oral squamous cell carcinoma OR oropharyngeal cancer) AND (time interval OR diagnostic delay))...
June 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28626736/enterococcus-spp-and-s-aureus-colonization-in-neutropenic-febrile-children-with-cancer
#8
Julia R Spinardi, Rodrigo Berea, Patricia A Orioli, Marina M Gabriele, Alessandra Navarini, Marina T Marques, Milton N Neto, Marcelo J Mimica
INTRODUCTION: Febrile neutropenia is one of the most serious treatment-related complications in cancer patients. Susceptible to rapidly progressing infections, which result in prolonged hospitalization and use of broad-spectrum antibiotics, neutropenic patients are subject to colonization by multiresistant agents, which enhances the risk of infections. METHODS: In this study we included samples collected with nasal, oropharyngeal and anal swabs from hospitalized children with febrile neutropenia following chemotherapy, between March 2014 and 2015, aiming to elucidate colonization by S...
June 2017: Germs
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#9
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28619685/molecular-mechanisms-of-human-papillomavirus-related-carcinogenesis-in-head-and-neck-cancer
#10
REVIEW
Farhoud Faraji, Munfarid Zaidi, Carole Fakhry, Daria A Gaykalova
This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.
June 12, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28618252/epidemiological-trends-of-head-and-neck-cancer-in-the-united-states-a%C3%A2-seer-population-study
#11
Moustafa Mourad, Thomas Jetmore, Ameya A Jategaonkar, Sami Moubayed, Erin Moshier, Mark L Urken
PURPOSE: This study represents the most recent epidemiologic trends of head and neck cancer (HNC) in the United States. It provides an important discussion on oropharyngeal cancer and cancers related to the human papillomavirus. The objective was to identify trends in HNC (2002 to 2012) within the United States. MATERIALS AND METHODS: This study is a retrospective analysis of the US National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) submission...
May 22, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28611308/an-oral-keratinocyte-life-cycle-model-identifies-novel-host-genome-regulation-by-human-papillomavirus-16-relevant-to-hpv-positive-head-and-neck-cancer
#12
Michael R Evans, Claire D James, Oonagh Loughran, Tara J Nulton, Xu Wang, Molly L Bristol, Brad Windle, Iain M Morgan
Many aspects of the HPV life cycle have been characterized in cervical cell lines (W12, CIN612) and in HPV immortalized primary foreskin keratinocytes. There is now an epidemic of HPV positive oropharyngeal cancers (HPV16 is responsible for 80-90% of these); therefore increased understanding of the HPV16 life cycle in oral keratinocytes is a priority. To date there have been limited reports characterizing the HPV16 life cycle in oral keratinocytes. Using TERT immortalized "normal" oral keratinocytes (NOKs) we generated clonal cell lines maintaining the HPV16 genome as an episome, NOKs+HPV16...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608925/osteoradionecrosis-of-the-mandible-in-patients-with-oropharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#13
Francesca Caparrotti, Shao Hui Huang, Lin Lu, Scott V Bratman, Jolie Ringash, Andrew Bayley, John Cho, Meredith Giuliani, John Kim, John Waldron, Aaron Hansen, Li Tong, Wei Xu, Brian O'Sullivan, Robert Wood, David Goldstein, Andrew Hope
BACKGROUND: Osteoradionecrosis (ORN) of the mandible is a late toxicity affecting patients treated with radiotherapy for head and neck malignancies. To the authors' knowledge, ORN has no standardized grading system and its reporting is based on retrospective findings in heterogeneous patient populations. The rate of ORN in the era of intensity-modulated radiotherapy (IMRT) still is unknown. METHODS: The authors report the incidence of ORN from prospectively collected data regarding 1196 patients who were diagnosed with squamous cell carcinoma of the oropharynx and treated with curative-intent IMRT, with or without concomitant systemic treatment, from January 2005 to December 2014...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28608796/the-natural-history-of-oral-human-papillomavirus-in-young-costa-rican-women
#14
Daniel C Beachler, Krystle A Lang Kuhs, Linda Struijk, John Schussler, Rolando Herrero, Carolina Porras, Allan Hildesheim, Bernal Cortes, Joshua Sampson, Wim Quint, Paula Gonzalez, Aimée R Kreimer
BACKGROUND: Oral human papillomavirus (HPV) infection and related oropharyngeal cancer are uncommon in lower-income countries, particularly compared to HPV-associated cervical cancer. However, little is known about the natural history of oral HPV in less-developed settings and how it compares to the natural history of cervical HPV. METHODS: Three hundred fifty women aged 22 to 33 years from the Costa Rica Vaccine Trial provided exfoliated cells from the cervical and oral regions at 2 visits 2 years apart...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28607924/hipk2-overexpression-and-its-prognostic-role-in-human-papillomavirus-positive-tonsillar-squamous-cell-carcinoma
#15
Mi Jung Kwon, So Young Kang, Eun Sook Nam, Seong Jin Cho, Young-Soo Rho
Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is involved in HPV-associated uterine cervical and cutaneous carcinogenesis through its binding of HPV E6, thereby preventing apoptosis and contributing to tumor progression. However, its clinical and prognostic significance in TSCC remains unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28607383/isolation-detection-and-quantification-of-cancer-biomarkers-in-hpv-associated-malignancies
#16
Hakan Inan, Shuqi Wang, Fatih Inci, Murat Baday, Richard Zangar, Sailaja Kesiraju, Karen S Anderson, Brian T Cunningham, Utkan Demirci
Human Papillomavirus (HPV) infection has been recognized as the main etiologic factor in the development of various cancers including penile, vulva, oropharyngeal and cervical cancers. In the development of cancer, persistent HPV infections induce E6 and E7 oncoproteins, which promote cell proliferation and carcinogenesis resulting elevated levels of host antibodies (e.g., anti-HPV16 E7 antibody). Currently, these cancers are clinically diagnosed using invasive biopsy-based tests, which are performed only in centralized labs by experienced clinical staff using time-consuming and expensive tools and technologies...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606831/relationship-between-dental-status-and-development-of-osteoradionecrosis-of-the-jaw-a-multicenter-retrospective-study
#17
Yuka Kojima, Souichi Yanamoto, Masahiro Umeda, Yumiko Kawashita, Izumi Saito, Takumi Hasegawa, Takahide Komori, Nobuhiro Ueda, Tadaaki Kirita, Shin-Ichi Yamada, Hiroshi Kurita, Yasuko Senga, Yasuyuki Shibuya, Hiroshi Iwai
OBJECTIVE: Osteoradionecrosis of the jaw is a serious late adverse event in patients with head and neck cancer undergoing radiotherapy. The aim of this study is to investigate the relationship between dental status and development of osteoradionecrosis. STUDY DESIGN: Multicenter, retrospective observational study. A total of 392 patients with head and neck cancer who underwent radiotherapy were investigated for correlations between the development of osteoradionecrosis and various factors...
May 4, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28604441/increasing-human-papillomavirus-vaccine-coverage-among-men-who-have-sex-with-men-national-hiv-behavioral-surveillance-united-states-2014
#18
Sara E Oliver, Brooke E Hoots, Gabriela Paz-Bailey, Lauri E Markowitz, Elissa Meites
BACKGROUND: Human papillomavirus (HPV) can cause oropharyngeal and anogenital cancers among men who have sex with men (MSM). In 2011, the Advisory Committee on Immunization Practices (ACIP) extended HPV vaccine recommendations to males through age 21 and MSM through age 26. Because of this distinction, vaccination for some MSM might rely on sexual behavior disclosure to health care providers. Receipt of ≥1 HPV vaccination among MSM aged 18-26 in National HIV Behavioral Surveillance (NHBS) was 4...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604368/predictive-modeling-of-outcomes-following-definitive-chemoradiotherapy-for-oropharyngeal-cancer-based-on-fdg-pet-image-characteristics
#19
Michael R Folkert, Jeremy Setton, Aditya P Apte, Milan Grkovski, Robert J Young, Heiko Schöder, Wade L Thorstad, Nancy Y Lee, Joseph O Deasy, Jung Hun Oh
In this study, we investigate the use of imaging feature-based outcomes research ('radiomics') combined with machine learning techniques to develop robust predictive models for the risk of all-cause mortality (ACM), local failure (LF), and distant metastasis (DM) following definitive chemoradiation therapy (CRT). One hundred seventy four patients with stage III-IV oropharyngeal cancer (OC) treated at our institution with CRT with retrievable pre- and post-treatment 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans were identified...
July 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28601094/prognostic-factors-for-head-and-neck-cancer-of-unknown-primary-including-the-impact-of-human-papilloma-virus-infection
#20
Lars Axelsson, Jan Nyman, Hedda Haugen-Cange, Mogens Bove, Leif Johansson, Shahin De Lara, Anikó Kovács, Eva Hammerlid
BACKGROUND: Head and neck cancer of unknown primary (HNCUP) is rare and prospective studies are lacking. The impact of different prognostic factors such as age and N stage is not completely known, the optimal treatment is not yet established, and the reported survival rates vary. In the last decade, human papilloma virus (HPV) has been identified as a common cause of and important prognostic factor in oropharyngeal cancer, and there is now growing interest in the importance of HPV for HNCUP...
June 10, 2017: Journal of Otolaryngology—Head & Neck Surgery
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