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https://www.readbyqxmd.com/read/28820495/human-papillomavirus-and-the-dna-damage-response-exploiting-host-repair-pathways-for-viral-replication
#1
REVIEW
Chelsey C Spriggs, Laimonis A Laimins
High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other genital cancers. In addition, HPV infections are associated with the development of many oropharyngeal cancers. HPVs activate and repress a number of host cellular pathways to promote their viral life cycles, including those of the DNA damage response. High-risk HPVs activate the ataxia telangiectasia-mutated (ATM) and ATM and Rad3-related (ATR) DNA damage repair pathways, which are essential for viral replication (particularly differentiation-dependent genome amplification)...
August 18, 2017: Viruses
https://www.readbyqxmd.com/read/28816937/effect-of-perioperative-oral-care-on-prevention-of-postoperative-pneumonia-associated-with-esophageal-cancer-surgery-a-multicenter-case-control-study-with-propensity-score-matching-analysis
#2
Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Shin-Ichi Yamada, Hiroshi Kurita, Chika Yamauchi, Yasuyuki Shibuya, Yuka Kojima, Hirokazu Nakahara, Takahiko Oho, Masahiro Umeda
The aim of this study was to investigate the effectiveness of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery.Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery. It is thought to be caused by aspiration of oropharyngeal fluid containing pathogens. However, the relationship between oral health status and postoperative pneumonia has not been well investigated.This study included 539 patients with esophageal cancer undergoing surgery at 1 of 7 university hospitals...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816156/erratum-to-ringash-j-fisher-r-peters-l-et%C3%A2-al-effect-of-p16-status-on-the-quality-of-life-experience-during-chemoradiation-for-locally-advanced-oropharyngeal-cancer-a-substudy-of-randomized-trial-trans-tasman-radiation-oncology-group-trog-%C3%A2-02-02-headstart
#3
https://www.readbyqxmd.com/read/28815861/radiation-and-chemotherapy-with-no-excessive-toxicity-in-a-patient-with-human-papillomavirus-related-tonsillar-cancer-and-porphyria-cutanea-tarda-case-report-and-literature-review
#4
James K Russo, Annie Braseth
BACKGROUND: Porphyria is a condition of cutaneous photosensitivity. It is unclear if radiotherapy (RT) is safe in patients with porphyria. METHODS: We report a patient case with uncontrolled porphyria cutanea tarda treated with chemoradiation for p16-positive oropharyngeal cancer. Given the scarcity of data on this subject, we also conducted a literature review on the topic of radiation in patients with porphyria. RESULTS: The patient in our study did not experience any unusual acute or late toxicity, despite receiving a high dose of cutaneous radiation...
August 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815336/treatment-selection-in-oropharyngeal-cancer-a-surveillance-epidemiology-and-end-results-seer-patterns-of-care-analysis
#5
Nitin A Pagedar, Catherine Chioreso, Jennifer A Schlichting, Charles F Lynch, Mary E Charlton
PURPOSE: Treatment for oropharyngeal cancer (OPC) has changed over the past two decades under multiple influences. We provide a population-based description of the application of radiotherapy, surgery, and chemotherapy to OPC in 1997, 2004, and 2009. METHODS: The National Cancer Institute's Patterns of Care study for OPC included multiple variables not available in the public-use dataset. We identified factors correlating with selection of primary surgery versus radiotherapy with or without chemotherapy (RTC) and analyzed predictors of all-cause mortality...
August 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28812214/the-role-of-human-papillomavirus-on-the-prognosis-and-treatment-of-oropharyngeal-carcinoma
#6
Nicholas Fung, Farhoud Faraji, Hyunseok Kang, Carole Fakhry
Human papillomavirus positive oropharyngeal cancer (HPV-positive OPC) is a distinct subtype of head and neck carcinoma (HNC) distinguished from HPV-negative HNC by its risk factor profile, clinical behavior, and molecular biology. Compared to HPV-negative HNC, HPV-positive OPC exhibits significantly better prognosis and an enhanced response to treatment. Recognition of the survival benefit of HPV-positive tumors has led to therapeutic de-intensification strategies aiming to mitigate treatment-related toxicities while maintaining high response rates...
August 15, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28808115/human-papillomavirus-in-oropharyngeal-cancer-in-canada-analysis-of-5-comprehensive-cancer-centres-using-multiple-imputation
#7
MULTICENTER STUDY
Steven Habbous, Karen P Chu, Harold Lau, Melissa Schorr, Mathieos Belayneh, Michael N Ha, Scott Murray, Brian O'Sullivan, Shao Hui Huang, Stephanie Snow, Matthew Parliament, Desiree Hao, Winson Y Cheung, Wei Xu, Geoffrey Liu
BACKGROUND: The incidence of oropharyngeal cancer has risen over the past 2 decades. This rise has been attributed to human papillomavirus (HPV), but information on temporal trends in incidence of HPV-associated cancers across Canada is limited. METHODS: We collected social, clinical and demographic characteristics and p16 protein status (p16-positive or p16-negative, using this immunohistochemistry variable as a surrogate marker of HPV status) for 3643 patients with oropharyngeal cancer diagnosed between 2000 and 2012 at comprehensive cancer centres in British Columbia (6 centres), Edmonton, Calgary, Toronto and Halifax...
August 14, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28799138/treatment-deintensification-for-human-papillomavirus-associated-oropharyngeal-cancer
#8
EDITORIAL
Demetri Arnaoutakis, Baran D Sumer
No abstract text is available yet for this article.
August 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28798073/the-human-papillomavirus-replication-cycle-and-its-links-to-cancer-progression-a-comprehensive-review
#9
REVIEW
Sheila V Graham
HPVs (human papillomaviruses) infect epithelial cells and their replication cycle is intimately linked to epithelial differentiation. There are over 200 different HPV genotypes identified to date and each displays a strict tissue specificity for infection. HPV infection can result in a range of benign lesions, for example verrucas on the feet, common warts on the hands, or genital warts. HPV infects dividing basal epithelial cells where its dsDNA episomal genome enters the nuclei. Upon basal cell division, an infected daughter cell begins the process of keratinocyte differentiation that triggers a tightly orchestrated pattern of viral gene expression to accomplish a productive infection...
September 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28797468/incidence-of-and-risk-factors-for-mandibular-osteoradionecrosis-in-patients-with-oral-cavity-and-oropharynx-cancers
#10
Dominic H Moon, Sung Ho Moon, Kyle Wang, Mark C Weissler, Trevor G Hackman, Adam M Zanation, Brian D Thorp, Samip N Patel, Jose P Zevallos, Lawrence B Marks, Bhishamjit S Chera
OBJECTIVES: To evaluate the incidence of, and risk factors associated with, mandibular osteoradionecrosis (MORN) following radiation therapy (RT) for oral cavity and oropharyngeal cancers. MATERIALS AND METHODS: Patient and treatment records of 252 consecutive patients with oral cavity or oropharynx cancers treated with RT by a single radiation oncologist at a high volume academic institution from August 2009 to December 2015 were retrospectively reviewed. A Cox regression model was used to assess factors associated with the development of MORN...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797454/impact-of-early-prophylactic-feeding-on-long-term-tube-dependency-outcomes-in-patients-with-head-and-neck-cancer
#11
Teresa Brown, Merrilyn Banks, Brett G M Hughes, Charles Lin, Lizbeth M Kenny, Judith D Bauer
OBJECTIVES: Prophylactic gastrostomy tube (PGT) is frequently used in patients with head and neck cancer (HNSCC). There are concerns this leads to tube dependency but this phenomena is not well defined. This study aimed to determine whether early feeding via PGT impacted on longer term tube feeding outcomes. MATERIALS AND METHODS: Patients with HNSCC with PGT were observed monthly post-treatment regarding tube use and time to removal up to twelve months. Patients were from a randomised controlled trial comparing an early feeding intervention via the PGT (n=57) versus usual care which commenced feeding when clinically indicated (n=67)...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797450/tube-feeding-during-treatment-for-head-and-neck-cancer-adherence-and-patient-reported-barriers
#12
Teresa Brown, Merrilyn Banks, Brett G M Hughes, Charles Lin, Lizbeth Kenny, Judith Bauer
OBJECTIVES: The main aim was to investigate the incidence of patient adherence to nutritional tube feeding recommendations in patients with head and neck cancer and to determine patient barriers to meeting tube feeding prescription. MATERIALS AND METHODS: This was an observational study from a randomised controlled trial in patients with head and neck cancer deemed at high nutritional risk with prophylactic gastrostomy (n=125). Patients were randomised to receive early tube feeding prior to treatment (intervention group) or standard care...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797447/evaluation-of-the-xpert%C3%A2-hpv-assay-in-the-detection-of-human-papillomavirus-in-formalin-fixed-paraffin-embedded-oropharyngeal-carcinomas
#13
Maria Gabriella Donà, Francesca Rollo, Barbara Pichi, Giuseppe Spriano, Raul Pellini, Renato Covello, Edoardo Pescarmona, Giulia Fabbri, Manuela Scalfari, Tarik Gheit, Maria Benevolo
OBJECTIVES: The increasing incidence of HPV-related Oropharyngeal Squamous Cell Carcinoma (OPSCC) and the improved survival of HPV-positive OPSCC highlight the need for effective tools in evaluating HPV status on formalin-fixed paraffin-embedded (FFPE) cancers. To date, there is no agreement regarding the most appropriate method for HPV testing on FFPE materials. We aimed to investigate the performance of the Xpert® HPV assay (Cepheid) on crude lysates from OPSCC FFPE tissues. MATERIALS AND METHODS: Crude lysates were obtained by proteinase K digestion of FFPE tissues that had already been analyzed by the INNO-LiPA HPV assay and p16(ink4a) immunostaining...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797119/a-retrospective-study-of-606-cases-of-nasopharyngeal-carcinoma-with-or-without-oropharyngeal-candidiasis-during-radiotherapy
#14
Wen-Ze Qiu, Liang-Ru Ke, Wei-Xiong Xia, Jing Yang, Ya-Hui Yu, Hu Liang, Xin-Jun Huang, Guo-Ying Liu, Wang-Zhong Li, Yan-Qun Xiang, Xiang Guo, Xing Lv
BACKGROUND: To evaluate the clinical characteristics, treatment-related toxicities and survival in patients with nasopharyngeal carcinoma (NPC) with or without oropharyngealcandidiasis (OPC) during radiotherapy. METHODS: The current study was conducted with NPC patients undergoing radiotherapy at Sun Yat-Sen University Cancer Center between June 2011 and May 2012. A clinical diagnosis of candidiasis was determined on the basis of a positive potassium hydroxide (KOH) test and the presence of pseudomembranous (white) form of candidal overgrowth...
2017: PloS One
https://www.readbyqxmd.com/read/28777690/development-and-validation-of-nomograms-predictive-of-overall-and-progression-free-survival-in-patients-with-oropharyngeal-cancer
#15
Carole Fakhry, Qiang Zhang, Phuc Felix Nguyen-Tân, David I Rosenthal, Randal S Weber, Louise Lambert, Andy M Trotti, William L Barrett, Wade L Thorstad, Christopher U Jones, Sue S Yom, Stuart J Wong, John A Ridge, Shyam S D Rao, James A Bonner, Eric Vigneault, David Raben, Mahesh R Kudrimoti, Jonathan Harris, Quynh-Thu Le, Maura L Gillison
Purpose Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). Methods To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522)...
August 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28771728/quality-of-life-outcomes-of-transoral-robotic-surgery-with-or-without-adjuvant-therapy-for-oropharyngeal-cancer
#16
Rishabh Sethia, Ali C Yumusakhuylu, Isa Ozbay, Virginia Diavolitsis, Nicole V Brown, Songzhu Zhao, Lai Wei, Matthew Old, Amit Agrawal, Theodoros N Teknos, Enver Ozer
OBJECTIVES/HYPOTHESIS: To compare quality of life (QOL) of patients who underwent transoral robotic surgery (TORS) alone, with adjuvant radiation therapy (RT), or adjuvant chemoradiation therapy (CRT) in the treatment of oropharyngeal squamous cell cancer (OPSCCA). STUDY DESIGN: Prospective cohort study. METHODS: Medical records were reviewed for 111 patients treated for OPSCCA from 2008 to 2015. Patients were administered the Head and Neck Cancer Inventory (HNCI) to evaluate QOL preoperatively, and at 3 weeks, 3 months, 6 months, and 1 year postsurgery...
August 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28771189/integration-of-human-papillomavirus-genomes-in-head-and-neck-cancer-is-it-time-to-consider-a-paradigm-shift
#17
REVIEW
Iain M Morgan, Laurence J DiNardo, Brad Windle
Human papillomaviruses (HPV) are detected in 70-80% of oropharyngeal cancers in the developed world, the incidence of which has reached epidemic proportions. The current paradigm regarding the status of the viral genome in these cancers is that there are three situations: one where the viral genome remains episomal, one where the viral genome integrates into the host genome and a third where there is a mixture of both integrated and episomal HPV genomes. Our recent work suggests that this third category has been mischaracterized as having integrated HPV genomes; evidence indicates that this category consists of virus-human hybrid episomes...
August 3, 2017: Viruses
https://www.readbyqxmd.com/read/28770294/automated-imrt-planning-in-pinnacle-a%C3%A2-study-in-head-and-neck-cancer
#18
J M A M Kusters, K Bzdusek, P Kumar, P G M van Kollenburg, M C Kunze-Busch, M Wendling, T Dijkema, J H A M Kaanders
PURPOSE: This study evaluates the performance and planning efficacy of the Auto-Planning (AP) module in the clinical version of Pinnacle 9.10 (Philips Radiation Oncology Systems, Fitchburg, WI, USA). METHODS AND MATERIALS: Twenty automated intensity-modulated radiotherapy (IMRT) plans were compared with the original manually planned clinical IMRT plans from patients with oropharyngeal cancer. RESULTS: Auto-Planning with IMRT offers similar coverage of the planning target volume as the original manually planned clinical plans, as well as better sparing of the contralateral parotid gland, contralateral submandibular gland, larynx, mandible, and brainstem...
August 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28764811/survival-impact-of-pre-treatment-neutrophils-on-oropharyngeal-and-laryngeal-cancer-patients-undergoing-definitive-radiotherapy
#19
Whitney A Sumner, William A Stokes, Ayman Oweida, Kiersten L Berggren, Jessica D McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D Karam
BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC)...
August 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28760331/the-applicability-of-new-tnm-classification-for-humanpapilloma-virus-related-oropharyngeal-cancer-in-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-in-japan-a-single-centre-study
#20
Daisuke Sano, Kenichiro Yabuki, Yasuhiro Arai, Teruhiko Tanabe, Yoshihiro Chiba, Goshi Nishimura, Hideaki Takahashi, Shoji Yamanaka, Nobuhiko Oridate
OBJECTIVE: The purpose of this study is to validate the applicability of new TNM classification for human papillomavirus (HPV)-related oropharyngeal cancer (OPC) in the 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) TNM staging system in Japan. METHODS: A total of 91 OPC patients treated with radiation-based therapy between January 2011 and December 2016 were analyzed retrospectively in this study. HPV infection status was evaluated using tumor p16 expression...
July 28, 2017: Auris, Nasus, Larynx
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