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https://www.readbyqxmd.com/read/29705266/elevated-serum-bdnf-levels-are-associated-with-favorable-outcome-in-cll-patients-possible-link-to-cxcr4-downregulation
#1
David Azoulay, Yair Herishanu, Mika Shapiro, Yarden Brenshaft, Celia Suriu, Luiza Akria, Andrei Braester
Increased CXCR4 expression is related to unfavorable disease in chronic lymphocytic leukemia (CLL). Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that has previously been shown to interact with CXCR4 in neuronal cells. In this report we studied the in vitro effect of BDNF on CXCR4 expression and chemotaxis towards SDF-1 in freshly isolated CLL cells. We also explored correlations between serum BDNF levels in CLL patients and the disease characteristics and clinical course. Incubation of CLL cells with recombinant BDNF (50 ng/ml) resulted in a downregulation of CXCR4 surface expression and atenuated chemotaxis towards SDF1...
April 26, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29693117/adenosine-a-2a-receptor-activation-reverses-hypoxia%C3%A2-induced-rat-pulmonary-artery-smooth-muscle-cell-proliferation-via-cyclic-amp%C3%A2-mediated-inhibition-of-the-sdf1%C3%A2-cxc4-signaling-pathway
#2
Yang Wang, Lei Ying, Ke-Ke Jin, Yan Nan, Suhua Hu, Xueqin Wu, Ruyi Qi, Xin Luo, Liangxing Wang
The occurrence and the subsequent development of pulmonary arterial hypertension (PAH) involve complicated mechanisms. Of these, the proliferation of pulmonary artery smooth muscle cells (PASMCs) has been indicated to be closely associated with its progression. Therefore, therapeutic methods targeting PASMCs to inhibit proliferation is an effective method for alleviating PAH. The present study was designed to determine the role of the adenosine A(2A) receptor (A2A receptor) in hypoxia‑induced rat PASMC (RPASMC) proliferation...
April 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29620151/low%C3%A2-intensity-pulsed-ultrasound-promotes-periodontal-ligament-stem-cell-migration-through-twist1%C3%A2-mediated-sdf%C3%A2-1-expression
#3
Yunji Wang, Jie Li, Ye Qiu, Bo Hu, Jin Chen, Tiwei Fu, Pengfei Zhou, Jinlin Song
Low‑intensity pulsed ultrasound (LIPUS) is a non‑invasive therapeutic treatment for accelerating fracture healing. A previous study from our group demonstrated that LIPUS has the potential to promote periodontal tissue regeneration. However, the underlying molecular mechanism by which LIPUS promotes periodontal tissue regeneration remains unknown. In the present study, periodontal ligament stem cells (PDLSCs) were isolated from premolars. Flow cytometry and differentiation assays were used to characterize the isolated PDLSCs...
March 27, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29596844/molecular-pathology-of-multiple-sclerosis-lesions-reveals-a-heterogeneous-expression-pattern-of-genes-involved-in-oligodendrogliogenesis
#4
T Zeis, O W Howell, R Reynolds, N Schaeren-Wiemers
Little is known about the decisive molecular factors that regulate lesion remyelination in Multiple Sclerosis. To identify such factors, we performed a differential gene expression analysis of normal appearing white matter (NAWM), active, remyelinating, and inactive demyelinated lesions. As expected, many genes involved in inflammatory processes were detected to be differentially regulated between these tissue types. Among them, we found an increased expression of members of the STAT6 pathway such as STAT6, IL4 and IL4R in active, remyelinated and inactive demyelinated lesions...
March 26, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29569832/bone-marrow-derived-mesenchymal-stem-cells-protect-islet-grafts-against-endoplasmic-reticulum-stress-induced-apoptosis-during-the-early-stage-after-transplantation
#5
Ying He, Dongmei Zhang, Yi Zeng, Junlei Ma, Jing Wang, Hui Guo, Ji Zhang, Mengqin Wang, Weijie Zhang, Nianqiao Gong
Early loss of grafted islets is the main obstacle to achieve favorable outcomes of islet transplantation. Mesenchymal stem cells are known to have a protective effect; however, its mechanism remains unclear. We hypothesized that bone marrow-derived mesenchymal stem cells (BMSCs) can protect grafted islets against endoplasmic reticulum stress (ERS)-induced apoptosis. In syngeneic streptozocin-induced diabetic BALB/c mice, islet grafts decreased blood glucose levels; however, the effect was not fully functional from the immediate post-transplant phase...
March 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/29540180/comparison-of-human-bone-marrow-stromal-cells-cultured-in-human-platelet-growth-factors-and-fetal-bovine-serum
#6
Jiaqiang Ren, Dawn Ward, Steven Chen, Katherine Tran, Ping Jin, Marianna Sabatino, Pamela G Robey, David F Stroncek
BACKGROUND: Bone marrow stromal cells (BMSCs) have classically been cultured in media supplemented with fetal bovine serum (FBS). As an alternative to FBS, pooled solvent detergent apheresis platelets, HPGF-C18, was evaluated for BMSC culture. METHODS: A comparison of passage 2 BMSC growth revealed that 10% HPGF-C18 produced similar cell numbers as 20% FBS. Marrow aspirates from 5 healthy subjects were cultured for 4 passages in 10% HPGF-C18 or 20% FBS and were analyzed for proliferation, colony formation efficiency (CFE), surface marker expression, suppression of mixed lymphocyte reactions (MLRs), global gene and microRNA expression analysis...
March 14, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29531541/sitagliptin-accelerates-endothelial-regeneration-after-vascular-injury-independent-from-glp1-receptor-signaling
#7
Friederike Remm, Nicolle Kränkel, Daniela Lener, Daniel J Drucker, Sieghart Sopper, Christoph Brenner
Introduction: DPP4 inhibitors (gliptins) are commonly used antidiabetic drugs for the treatment of type 2 diabetes. Gliptins also act in a glucose-independent manner and show vasoregenerative effects. We have shown that gliptins can remarkably accelerate vascular healing after vascular injury. However, the underlying mechanisms remain unclear. Here, we examined potential signaling pathways linking gliptins to enhanced endothelial regeneration. Methods and Results: We used wild-type and GLP1 receptor knockout ( Glp1r -/- ) mice to investigate the underlying mechanisms of gliptin-induced reendothelialization...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29525572/endogenous-mobilization-of-bone-marrow-cells-into-the-murine-retina-induces-fusion-mediated-reprogramming-of-m%C3%A3-ller-glia-cells
#8
Martina Pesaresi, Sergi A Bonilla-Pons, Giacoma Simonte, Daniela Sanges, Umberto Di Vicino, Maria Pia Cosma
Müller glial cells (MGCs) represent the most plastic cell type found in the retina. Following injury, zebrafish and avian MGCs can efficiently re-enter the cell cycle, proliferate and generate new functional neurons. The regenerative potential of mammalian MGCs, however, is very limited. Here, we showed that N-methyl-d-aspartate (NMDA) damage stimulates murine MGCs to re-enter the cell cycle and de-differentiate back to a progenitor-like stage. These events are dependent on the recruitment of endogenous bone marrow cells (BMCs), which, in turn, is regulated by the stromal cell-derived factor 1 (SDF1)-C-X-C motif chemokine receptor type 4 (CXCR4) pathway...
February 28, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29516335/stromal-derived-factor-1-directly-promotes-genes-expressed-within-the-ovulatory-cascade-in-feline-cumulus-oocyte-complexes
#9
Julieta L Rojo, Martina Linari, Kelly A Young, Marina C Peluffo
PURPOSE: We hypothesized that the chemokine SDF1/CXCR4 system was present in feline cumulus-oocyte complexes (COCs) and that COCs cultured with SDF1 would directly upregulate gene expression in the ovulatory cascade. METHODS: Ovaries (n = 50) were obtained from adult domestic cats during the breeding season and COCs were recovered from antral follicles. Because IVM media triggers cumulus-oocyte expansion, culture conditions needed to be optimized to study periovulatory genes...
March 8, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29475239/an-investigation-of-sdf1-cxcr4-gene-polymorphisms-in-autism-spectrum-disorder-a-family-based-study
#10
Tayfun Kara, İsmail Akaltun, Bedia Cakmakoglu, İlyas Kaya, Salih Zoroğlu
OBJECTIVE: Autism spectrum disorders (ASD) have a complex pathophysiology including genetic, inflammatory and neurodevelopmental components. We aim to investigate the relationship between ASD and gene polymorphisms of stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor-4 (CXCR4), which may affect inflammatory and neurodevelopmental processes. METHODS: 101 children diagnosed with ASD aged 2-18 and their biological parents were included in the study...
March 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29420545/association-of-gene-polymorphism-of-sdf1-cxcr12-with-susceptibility-to-hiv-1-infection-and-aids-disease-progression-a-meta-analysis
#11
Jiwei Ding, Jianyuan Zhao, Jinming Zhou, Xiaoyu Li, Yanbin Wu, Mei Ge, Shan Cen
OBJECTIVES: Genetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies. METHODS: Articles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29386050/curcumin-mediated-bone-marrow-mesenchymal-stem-cell-sheets-create-a-favorable-immune-microenvironment-for-adult-full-thickness-cutaneous-wound-healing
#12
Zhi Yang, Chengmin He, Jinyang He, Jing Chu, Hanping Liu, Xiaoyuan Deng
BACKGROUND: Adult full-thickness cutaneous wound repair suffers from an imbalanced immune response, leading to nonfunctional reconstructed tissue and fibrosis. Although various treatments have been reported, the immune-mediated tissue regeneration driven by biomaterial offers an attractive regenerative strategy for damaged tissue repair. METHODS: In this research, we investigated a specific bone marrow-derived mesenchymal stem cell (BMSC) sheet that was induced by the Traditional Chinese Medicine curcumin (CS-C) and its immunomodulatory effects on wound repair...
January 31, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29385398/pilose-antler-polypeptides-ameliorates-hypoxic-ischemic-encephalopathy-by-activated-neurotrophic-factors-and-sdf1-cxcr4-axis-in-rats
#13
Tao Wu, Luna Yang, Yan Chen, Yinhua Ni, Jianguo Jiang, Wanjing Zhang, Qianchen Zhou, Xiaojun Zheng, Qi Wang, Zhengwei Fu, Haifeng Li
Hypoxic-ischemic encephalopathy (HIE) is a complex condition which is associated with high mortality and morbidity. However, few promising treatments for HIE exist. In the present study, the central objective was to identify the therapeutic effect of pilose antler polypeptides (PAP) on HIE in rats. Sprague-Dawley (SD) rats (14 days old) were used and divided into three groups, including control group, hypoxic-ischemia (HI) group and PAP group. After 21 days of treatment, locomotor activity was improved in PAP-treated rats, brain atrophy was decreased and cerebral edema was mitigated to some extent...
March 1, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29382856/dynamic-cellular-phynotyping-defines-specific-mobilization-mechanisms-of-human-hematopoietic-stem-and-progenitor-cells-induced-by-sdf1%C3%AE-versus-synthetic-agents
#14
Cornelia Monzel, Alexandra S Becker, Rainer Saffrich, Patrick Wuchter, Volker Eckstein, Anthony D Ho, Motomu Tanaka
Efficient mobilization of hematopoietic stem and progenitor cells (HSPC) is one of the most crucial issues for harvesting an adequate amount of peripheral HSPC for successful clinical transplantation. Applying well-defined surrogate models for the bone marrow niche, live cell imaging techniques, and novel tools in statistical physics, we have quantified the functionality of two mobilization agents that have been applied in the clinic, NOX-A12 and AMD3100 (plerixafor), as compared to a naturally occurring chemokine in the bone marrow, SDF1α...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348441/sdf1-gradient-associates-with-the-distribution-of-c-kit-cardiac-cells-in-the-heart
#15
Outi Renko, Anna-Maria Tolonen, Jaana Rysä, Johanna Magga, Erja Mustonen, Heikki Ruskoaho, Raisa Serpi
Identification of the adult cardiac stem cells (CSCs) has offered new therapeutic possibilities for treating ischemic myocardium. CSCs positive for the cell surface antigen c-Kit are known as the primary source for cardiac regeneration. Accumulating evidence shows that chemokines play important roles in stem cell homing. Here we investigated molecular targets to be utilized in modulating the mobility of endogenous CSCs. In a four week follow-up after experimental acute myocardial infarction (AMI) with ligation of the left anterior descending (LAD) coronary artery of Sprague-Dawley rats c-Kit+ CSCs redistributed in the heart...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339648/caries-preventive-effect-of-naf-naf-plus-tcp-naf-plus-cpp-acp-and-sdf-varnishes-on-sound-dentin-and-artificial-dentin-caries-in-vitro
#16
Richard J Wierichs, Sabrina Stausberg, Julian Lausch, Hendrik Meyer-Lueckel, Marcella Esteves-Oliveira
The aim of this study was to compare the caries-preventive effect of different fluoride varnishes on sound dentin as well as on artificial dentin caries-like lesions. Bovine dentin specimens (n = 220) with one sound surface (ST) and one artificial caries lesion (DT) were prepared and randomly allocated to 11 groups. The interventions before pH cycling were as follows: application of a varnish containing NaF (22,600 ppm F-; Duraphat [NaF0/NaF1]), NaF plus tricalcium phosphate (22,600 ppm F-; Clinpro White Varnish Mint [TCP0/TCP1]), NaF plus casein phosphopeptide-stabilized amorphous calcium phosphate complexes (CPP-ACP; 22,600 ppm F-; MI Varnish [CPP0/CPP1]), or silver diamine fluoride (SDF; 35,400 ppm F-; Cariestop 30% [SDF0/SDF1]) and no intervention (NNB/N0/N1)...
2018: Caries Research
https://www.readbyqxmd.com/read/29314633/leucocyte-and-platelet-rich-fibrin-a-carrier-of-autologous-multipotent-cells-for-regenerative-medicine
#17
Rosa Di Liddo, Thomas Bertalot, Alessio Borean, Ivan Pirola, Alberto Argentoni, Sandra Schrenk, Carola Cenzi, Stefano Capelli, Maria Teresa Conconi, Pier Paolo Parnigotto
The wound healing is a complex process wherein inflammation, proliferation and regeneration evolve according to a spatio-temporal pattern from the activation of coagulation cascade to the formation of a plug clot including fibrin matrix, blood-borne cells and cytokines/growth factors. Creating environments conducive to tissue repair, the haemoderivatives are commonly proposed for the treatment of hard-to-heal wounds. Here, we explored in vitro the intrinsic regenerative potentialities of a leucocyte- and platelet-rich fibrin product, known as CPL-MB, defining the stemness grade of cells sprouting from the haemoderivative...
March 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29301984/stromal-cell-derived-factor-1-cxcl12-activates-integrins-by-direct-binding-to-an-allosteric-ligand-binding-site-site-2-of-integrins-without-cxcr4
#18
Masaaki Fujita, Parastoo Davari, Yoko K Takada, Yoshikazu Takada
Leukocyte arrest on the endothelial cell surface during leukocyte extravasation is induced by rapid integrin activation by chemokines. We recently reported that fractalkine induces integrin activation without its receptor CX3CR1 through binding to the allosteric site (site 2) of integrins. Peptides from site 2 bound to fractalkine and suppressed integrin activation by fractalkine. We hypothesized that this is not limited to membrane-bound fractalkine. We studied whether stromal cell-derived factor-1 (SDF1), another chemokine that plays a critical role in leukocyte arrest, activates integrins through binding to site 2...
February 16, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29258450/serum-cytokine-profiles-predict-survival-benefits-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-retrospective-cohort-study
#19
Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND: Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could predict the survival of advanced HCC patients, as sorafenib targets signaling pathways activated in the tumor stromal microenvironment and potentially affects serum cytokine profiles...
December 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29238372/transplantation-of-rat-mesenchymal-stem-cells-overexpressing-hypoxia-inducible-factor-2-%C3%AE-improves-blood-perfusion-and-arteriogenesis-in-a-rat-hindlimb-ischemia-model
#20
Weifeng Lu, Xiaoli Chen, Yi Si, Shichai Hong, Zhengyu Shi, Weiguo Fu
Mesenchymal stem cells (MSCs) have been increasingly tested in cell-based therapy to treat numerous diseases. Genetic modification to improve MSC behavior may enhance posttransplantation outcome. This study aims to test the potential therapeutic benefits of rat bone marrow MSCs overexpressing hypoxia-inducible factor 2 α (rMSCsHIF-2 α ) in a rat hindlimb ischemia model. PBS, rMSCs, or rMSCsHIF-2 α were injected into rat ischemic hindlimb. Compared with the injection of PBS or rMSCs, transplantation of rMSCsHIF-2 α significantly improved blood perfusion, increased the number of vessel branches in the muscle of the ischemic hindlimb, and improved the foot mobility of the ischemic hindlimb (all P < 0...
2017: Stem Cells International
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